{"id":55910,"date":"2021-12-08T20:56:00","date_gmt":"2021-12-08T13:56:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021120820560055910"},"modified":"2021-12-09T17:55:35","modified_gmt":"2021-12-09T09:55:35","slug":"gsk%e4%b8%8emedicago%e5%ae%a3%e5%b8%83%e6%96%b0%e5%86%a0%e6%a4%8d%e7%89%a9%e6%ba%90%e6%80%a7%e4%bd%90%e5%89%82%e5%80%99%e9%80%89%e7%96%ab%e8%8b%973%e6%9c%9f%e4%b8%b4%e5%ba%8a%e7%a7%af%e6%9e%81","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021120820560055910","title":{"rendered":"GSK\u4e0eMedicago\u5ba3\u5e03\u65b0\u51a0\u690d\u7269\u6e90\u6027\u4f50\u5242\u5019\u9009\u75ab\u82d73\u671f\u4e34\u5e8a\u79ef\u6781\u7ed3\u679c"},"content":{"rendered":"<ul type=\"disc\">\n<li>\u5df2\u83b7\u5f97\u7684\u9488\u5bf92019\u51a0\u72b6\u75c5\u6bd2\u75c5\u4e3b\u8981\u6d41\u884c\u7684\u53d8\u5f02\u682a\u7684\u8bd5\u9a8c\u6570\u636e\u5747\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\u548c\u6b21\u8981\u7ec8\u70b9 <\/li>\n<li>\u5bf9\u7814\u7a76\u4e2d\u68c0\u6d4b\u7684\u6240\u6709\u53d8\u5f02\u682a\u5747\u6709\u6548\uff0c\u5305\u62ec\u7531\u5168\u7403\u6d41\u884c\u7684\u5fb7\u5c14\u5854\uff08Delta\uff09\u53d8\u5f02\u682a\u5f15\u8d77\u7684\u4efb\u4f55\u4e25\u91cd\u7a0b\u5ea6\u7684\u65b0\u51a0\u80ba\u708e\uff0c<span id=\"spanHghlt6546\">\u5176\u6548\u529b\u4e3a75.3% <\/span><\/li>\n<li>\u5019\u9009\u75ab\u82d7\u8010\u53d7\u826f\u597d\uff0c\u75ab\u82d7\u7ec4\u4e2d\u6ca1\u6709\u76f8\u5173\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u62a5\u544a <\/li>\n<li>\u5373\u5c06\u5411\u52a0\u62ff\u5927\u536b\u751f\u90e8\u63d0\u4ea4\u6700\u7ec8\u6ce8\u518c\u7533\u62a5\u8d44\u6599 <\/li>\n<\/ul>\n<p><p>\u4e0a\u6d772021\u5e7412\u67088\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u845b\u5170\u7d20\u53f2\u514b\u516c\u53f8\uff08GSK\uff09\u4e0e\u603b\u90e8\u4f4d\u4e8e\u9b41\u5317\u514b\u5e02\u7684\u751f\u7269\u5236\u836f\u516c\u53f8Medicago\u8fd1\u65e5\u5ba3\u5e03\uff0c\u6dfb\u52a0\u4e86GSK\u5927\u6d41\u884c\u4f50\u5242\u76842019\u51a0\u72b6\u75c5\u6bd2\u690d\u7269\u6e90\u6027\u5019\u9009\u75ab\u82d7\u5728\u5168\u74033\u671f\u5b89\u6170\u5242\u5bf9\u7167\u6548\u529b\u7814\u7a76\u4e2d\uff0c\u5176\u6548\u529b\u548c\u5b89\u5168\u6027\u53d6\u5f97\u4e86\u79ef\u6781\u7684\u7ed3\u679c\u3002\u8be5\u7814\u7a76\u5728\u516d\u4e2a\u56fd\u5bb6\u768424,000\u591a\u4f8b\u53d7\u8bd5\u8005\uff0818\u5c81\u53ca\u4ee5\u4e0a\u6210\u5e74\u4eba\uff09\u4e2d\u8fdb\u884c\u3002 <\/p>\n<p>\u8be5\u75ab\u82d7\u6548\u529b\u5728\u4ee5SARS-CoV-2\u53d8\u5f02\u682a\u4e3a\u4e3b\u7684\u73af\u5883\u4e2d\u5f97\u5230\u8bc1\u660e\uff0c\u8fd9\u4e0e\u5927\u591a\u5df2\u516c\u5e03\u76843\u671f\u8bd5\u9a8c\u4e0d\u540c\u3002\u5927\u591a\u5df2\u516c\u5e03\u7684\u76ee\u524d\u5df2\u83b7\u8bb8\u53ef\u7684\u65b0\u51a0\u80ba\u708e\u75ab\u82d73\u671f\u6548\u529b\u8bd5\u9a8c\u90fd\u662f\u5728\u53ea\u6709\u539f\u59cb\u75c5\u6bd2\u4f20\u64ad\u65f6\u8fdb\u884c\u7684\uff0c\u65e0\u6cd5\u76f4\u63a5\u6bd4\u8f83\u3002\u8be5\u75ab\u82d7\u5bf9SARS-COV-2\u6240\u6709\u53d8\u5f02\u682a\u7684\u603b\u4f53\u75ab\u82d7\u6548\u529b\u4e3a71%\uff0895% CI\uff1a58.7\uff0c80.0\uff1b\u7b26\u5408\u65b9\u6848\u5206\u6790\uff1aPP\uff09\u3002\u5728\u672a\u53d1\u751f\u65b0\u51a0\u80ba\u708e\u66b4\u9732\u7684\u3001\u521d\u59cb\u8840\u6e05\u9634\u6027\u72b6\u6001\u7684\u4eba\u7fa4\u4e2d\uff0c\u76f8\u5e94\u7684\u6548\u529b\u4e3a75.6%\uff0895% CI\uff1a64.2-83.7\uff1bPP\uff09\u3002\u8be5\u5019\u9009\u75ab\u82d7\u5bf9\u5168\u7403\u4e3b\u8981\u6d41\u884c\u7684Delta\u53d8\u5f02\u682a\u6240\u5f15\u8d77\u7684\u6240\u6709\u4e25\u91cd\u7a0b\u5ea6\u65b0\u51a0\u80ba\u708e\u7684\u6548\u529b\u4e3a75.3%\uff0895% CI\uff1a52.8\uff0c87.9\uff1bPP\uff09\u3002\u5bf9Gamma\u53d8\u5f02\u682a\u7684\u6548\u529b\u4e3a88.6%\uff0895% CI\uff1a74.6\uff0c95.6\uff1bPP\uff09\u3002\u5c3d\u7ba1\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\u53d1\u751f\u4e86\u5c11\u91cf\u4e25\u91cd\u75c5\u4f8b\uff0c\u4f46\u5728\u75ab\u82d7\u63a5\u79cd\u7ec4\u4e2d\u6ca1\u6709\u53d1\u751f\u3002\u5728\u63a5\u79cd\u7ec4\u4e2d\u6ca1\u6709\u89c2\u5bdf\u5230Alpha\u3001Lambda\u548cMu\u53d8\u5f02\u682a\u75c5\u4f8b\uff0c\u5728\u5b89\u6170\u5242\u7ec4\u4e2d\u89c2\u5bdf\u523012\u4f8b\u3002\u7814\u7a76\u671f\u95f4\uff0c\u5965\u5bc6\u514b\u620e\uff08Omicron\uff09\u53d8\u5f02\u682a\u5c1a\u672a\u6d41\u884c\u3002<\/p>\n<p>\u7814\u7a76\u671f\u95f4\uff0c\u65e0\u76f8\u5173\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u62a5\u544a\uff0c\u53cd\u5e94\u539f\u6027\u4e00\u822c\u4e3a\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\u4e14\u4e3a\u4e00\u8fc7\u6027\uff1b\u75c7\u72b6\u5e73\u5747\u4ec5\u6301\u7eed\u4e00\u5230\u4e09\u5929\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0c3\u671f\u7814\u7a76\u7ed3\u679c\u5df2\u8bc1\u5b9e\u5176\u5b89\u5168\u6027\u7279\u5f81\u4e0e2\u671f\u7814\u7a76\u7ed3\u679c\u4e00\u81f4\u3002\u5373\u4f7f\u662f\u5728\u7b2c\u4e8c\u5242\u63a5\u79cd\u540e\uff0c\u8f7b\u5ea6\u53d1\u70ed\u7684\u53d1\u751f\u7387\u4e5f\u8f83\u4f4e\uff08&lt;10%\uff09\u30023\u671f\u7814\u7a76\u7684\u5168\u90e8\u7ed3\u679c\u5c06\u4f1a\u5c3d\u5feb\u5728\u540c\u884c\u8bc4\u5ba1\u51fa\u7248\u7269\u4e2d\u516c\u5e03\u3002 <\/p>\n<p>\u57fa\u4e8e\u8fd9\u4e9b\u7ed3\u679c\uff0cMedicago\u5c06\u7acb\u5373\u5411\u52a0\u62ff\u5927\u536b\u751f\u90e8\u5bfb\u6c42\u6ce8\u518c\u6279\u51c6\uff0c\u4f5c\u4e3a\u5176\u6eda\u52a8\u7533\u8bf7\u7684\u4e00\u90e8\u5206\u3002\u8be5\u5019\u9009\u75ab\u82d7\u76ee\u524d\u5c1a\u672a\u5f97\u5230\u4efb\u4f55\u76d1\u7ba1\u673a\u6784\u6279\u51c6\u3002 <\/p>\n<p>\u201c\u5bf9\u4e8eMedicago\u548c\u65b0\u578b\u75ab\u82d7\u5e73\u53f0\uff0c\u8fd9\u662f\u4e00\u4e2a\u4e0d\u53ef\u601d\u8bae\u7684\u65f6\u523b\u3002\u6211\u4eec\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\u690d\u7269\u6e90\u6027\u75ab\u82d7\u5236\u9020\u6280\u672f\u7684\u529b\u91cf\u3002\u5982\u679c\u83b7\u5f97\u6279\u51c6\uff0c\u5b83\u5c06\u6210\u4e3a\u4e16\u754c\u9996\u4e2a\u7528\u4e8e\u4eba\u7c7b\u7684\u690d\u7269\u6e90\u6027\u75ab\u82d7\uff0c\u5e76\u4e3a\u4e16\u754c\u6297\u51fb\u65b0\u51a0\u80ba\u708e\u5927\u6d41\u884c\u4f5c\u51fa\u8d21\u732e\u3002<span id=\"spanHghlt7db7\">\u201d<\/span>Medicago<b>\u516c\u53f8\u9996\u5e2d\u6267\u884c\u5b98\u517c\u603b\u88c1<\/b><b><span class=\"xn-person\">Takashi Nagao<\/span><\/b><b>\u8868\u793a\uff0c<\/b>\u201c\u6211\u8981\u611f\u8c22\u53c2\u52a0\u6211\u4eec\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6240\u6709\u4eba\u3001\u4e34\u5e8a\u8bd5\u9a8c\u57fa\u5730\u7684\u5408\u4f5c\u8005\u3001GSK\u7684\u5408\u4f5c\u4f19\u4f34\uff0c\u52a0\u62ff\u5927\u653f\u5e9c\u548c\u9b41\u5317\u514b\u653f\u5e9c\u3001\u516c\u53f8\u6240\u6709\u5458\u5de5\u548c\u4e09\u83f1\u7530\u8fb9\u5236\u836f\uff0c\u611f\u8c22\u4ed6\u4eec\u5728\u4e16\u754c\u9700\u8981\u65f6\u4e3a\u63a8\u52a8\u75ab\u82d7\u79d1\u5b66\u53d1\u5c55\u6240\u4f5c\u7684\u8d21\u732e\u3002<span id=\"spanHghlt7db7\">\u201d<\/span><\/p>\n<p><b>GSK<\/b><b>\u5168\u7403\u65b0\u51a0\u80ba\u708e\u4f50\u5242\u75ab\u82d7\u8d1f\u8d23\u4eba\u517c\u9996\u5e2d\u533b\u5b66\u5b98<\/b><b><span class=\"xn-person\">Thomas Breuer<\/span><\/b><b>\u8868\u793a\uff1a<\/b>\u201c\u6570\u636e\u662f\u5728\u65e0\u539f\u59cb\u6bd2\u682a\u6d41\u884c\u7684\u73af\u5883\u4e0b\u83b7\u5f97\u7684\uff0c\u8fd9\u4e9b\u7ed3\u679c\u4ee4\u4eba\u9f13\u821e\u3002\u5168\u7403\u65b0\u51a0\u80ba\u708e\u5927\u6d41\u884c\u4ecd\u5728\u6301\u7eed\u8868\u73b0\u51fa\u65b0\u7684\u7279\u5f81\uff0c\u76ee\u524d\u5fb7\u5c14\u5854\u53d8\u5f02\u682a\u5360\u4e3b\u5bfc\u5730\u4f4d\uff0c\u5965\u5bc6\u514b\u620e\u53d8\u5f02\u682a\u4e5f\u521d\u9732\u7aef\u502a\uff0c\u5176\u4ed6\u53d8\u5f02\u682a\u4e5f\u53ef\u80fd\u63a5\u8e35\u800c\u81f3\u3002GSK\u73b0\u6709\u7684\u5927\u6d41\u884c\u4f50\u5242\u4e0eMedicago\u516c\u53f8\u7684\u690d\u7269\u75ab\u82d7\u6280\u672f\u76f8\u7ed3\u5408\uff0c\u6781\u5176\u6709\u671b\u6210\u4e3a\u4e00\u79cd\u6709\u6548\u7684\u3001\u53ef\u5728\u51b7\u85cf\u6761\u4ef6\u4e0b\u4fdd\u6301\u7a33\u5b9a\u7684\u75ab\u82d7\u9009\u62e9\uff0c\u5e2e\u52a9\u4eba\u4eec\u5e94\u5bf9SARS-CoV-2\u3002\u201d&nbsp;<\/p>\n<p>\u5728\u8fc7\u53bb\u768420\u5e74\u91cc\uff0cMedicago\u59cb\u7ec8\u81f4\u529b\u4e8e\u5f00\u53d1\u57fa\u4e8e\u690d\u7269\u7684\u6280\u672f\uff0c\u5e76\u901a\u8fc7\u8fd9\u79cd\u72ec\u7279\u6280\u672f\u4e3a\u5176\u86cb\u767d\u8d28\u7c7b\u75ab\u82d7\u751f\u4ea7\u75c5\u6bd2\u6837\u9897\u7c92\uff08VLP\uff09\u3002VLP\u7684\u8bbe\u8ba1\u53ef\u4ee5\u6a21\u62df\u75c5\u6bd2\u7684\u539f\u59cb\u7ed3\u6784\uff0c\u4f7f\u5176\u5bb9\u6613\u88ab\u514d\u75ab\u7cfb\u7edf\u8bc6\u522b\u3002\u56e0\u4e3aVLP\u7f3a\u4e4f\u6838\u5fc3\u9057\u4f20\u7269\u8d28\uff0c\u6240\u4ee5\u5b83\u4eec\u6ca1\u6709\u611f\u67d3\u6027\uff0c\u65e0\u6cd5\u590d\u5236\u3002\u901a\u8fc7\u5176\u4ed6\u6280\u672f\u5f00\u53d1\u7684VLP\u75ab\u82d7\u5df2\u5728\u4e16\u754c\u8303\u56f4\u5185\u4f7f\u7528\u8d85\u8fc730\u5e74\u3002 <\/p>\n<p><span id=\"spanHghlt7db7\">\u201c<\/span>\u6211\u5f88\u9ad8\u5174\u770b\u5230\u6211\u4eec\u7684\u5019\u9009\u75ab\u82d7\u80fd\u591f\u7ee7\u7eed\u63a8\u8fdb\uff0c\u5e76\u4e3a\u4e16\u754c\u5e26\u6765\u9996\u4e2a\u9488\u5bf9\u65b0\u51a0\u80ba\u708e\u7684\u690d\u7269\u6e90\u6027\u75ab\u82d7\uff0c\u63d0\u9ad8\u4e86\u53ef\u7528\u75ab\u82d7\u7684\u591a\u6837\u6027\uff0c\u6709\u52a9\u4e8e\u6539\u5584\u516c\u5171\u5065\u5eb7\u5e76\u4fdd\u62a4\u66f4\u591a\u7684\u4eba\u3002<span id=\"spanHghlt7db7\">\u201d<\/span>Medicago\u516c\u53f8\u9996\u5e2d\u79d1\u5b66\u5b98Yosuke Kimura\u8868\u793a\u3002 <\/p>\n<p>Medicago\u5df2\u542f\u52a8\u690d\u7269\u6e90\u6027\u4f50\u5242\u65b0\u51a0\u80ba\u708e\u5019\u9009\u75ab\u82d7\u5728\u7f8e\u56fdFDA\u548c\u82f1\u56fdMHRA\u7684\u6ce8\u518c\u7533\u62a5\u7a0b\u5e8f\u3002\u76ee\u524d\u6b63\u4e0e\u4e16\u536b\u7ec4\u7ec7\u8fdb\u884c\u521d\u6b65\u8ba8\u8bba\uff0c\u51c6\u5907\u63d0\u4ea4\u6750\u6599\u3002Medicago\u8fd8\u5728\u65e5\u672c\u542f\u52a8\u4e86\u4e00\u98791\/2\u671f\u8bd5\u9a8c\uff0c\u5e76\u8ba1\u5212\u5728\u660e\u5e74\u6625\u5b63\u7ed3\u54082\/3\u671f\u5168\u7403\u7814\u7a76\u7ed3\u679c\u63d0\u4ea4\u6ce8\u518c\u5ba1\u6279\u3002 <\/p>\n<p><b>\u5173\u4e8e<\/b><b>2\/3<\/b><b>\u671f\u7814\u7a76 <\/b><\/p>\n<p>\u8be52\/3\u671f\u7814\u7a76\u91c7\u7528\u4e86\u591a\u90e8\u5206\u8bbe\u8ba1\uff0c\u65e8\u5728\u786e\u8ba4\u6240\u9009\u5019\u9009\u75ab\u82d7\u914d\u65b9\u548c\u63a5\u79cd\u7a0b\u5e8f\uff08\u4e24\u52423.75 <span id=\"spanHghlt1414\">\u5fae\u514b<\/span>\u6297\u539f\uff0c\u8054\u5408GSK\u5927\u6d41\u884c\u4f50\u5242\uff0c\u95f4\u969421\u5929\uff09\u572818-64\u5c81\u7684\u5065\u5eb7\u6210\u5e74\u4eba\u300165\u5c81\u53ca\u4ee5\u4e0a\u7684\u8001\u5e74\u53d7\u8bd5\u8005\u548c\u6709\u5408\u5e76\u75c7\u7684\u6210\u5e74\u4eba\u4e2d\u5177\u6709\u826f\u597d\u7684\u75ab\u82d7\u7279\u5f81\u3002 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