{"id":55070,"date":"2021-12-03T07:00:00","date_gmt":"2021-12-03T00:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021120307000055070"},"modified":"2021-12-03T17:53:25","modified_gmt":"2021-12-03T09:53:25","slug":"%e9%bc%8e%e4%b8%b0%e7%94%9f%e7%a7%91%e8%b5%84%e6%9c%ac%e9%a2%86%e6%8a%95%e6%88%90%e7%ab%8b%e5%90%88%e8%b5%84%e5%85%ac%e5%8f%b8sanreno-therapeutics","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021120307000055070","title":{"rendered":"\u9f0e\u4e30\u751f\u79d1\u8d44\u672c\u9886\u6295\u6210\u7acb\u5408\u8d44\u516c\u53f8SanReno Therapeutics"},"content":{"rendered":"

\u8fdb\u519b\u80be\u79d1\u9886\u57df<\/span><\/p>\n

<\/span> <\/b> <\/span> <\/b> <\/p>\n

\u4e0a\u6d772021\u5e7412\u67083\u65e5 \/\u7f8e\u901a\u793e\/ — \u9f0e\u4e30\u751f\u79d1\u8d44\u672c\uff08Pivotal bioVenture Partners China\uff09\uff0c\u4e00\u5bb6\u5728\u751f\u547d\u79d1\u5b66\u9886\u57df\u9886\u5148\u7684\u98ce\u6295\u57fa\u91d1\u4eca\u65e5\u5ba3\u5e03\uff0c\u4e0e\u7f8e\u56fd\u77e5\u540d\u533b\u7597\u57fa\u91d1Frazier Healthcare Partners\uff08\u4ee5\u4e0b\u7b80\u79f0\u201cFrazier\u201d\uff09\u4ee5\u53ca\u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u79d1\u6280\u516c\u53f8Chinook Therapeutics\uff08Nasdaq: KDNY\uff09\uff08\u4ee5\u4e0b\u7b80\u79f0\u201cChinook\u201d\uff09\u5171\u540c\u5728\u534e\u6210\u7acb\u5408\u8d44\u516c\u53f8SanReno Therapeutics<\/b>\uff08\u4ee5\u4e0b\u7b80\u79f0\u201cSanReno\u201d\uff09\uff0c\u5e76\u5b8c\u6210\u6570\u5343\u4e07\u7f8e\u91d1\u7684A\u8f6e\u80a1\u6743\u878d\u8d44\u3002\u65b0\u516c\u53f8\u5c06\u4e3b\u8981\u5728\u5927\u4e2d\u534e\u533a\u8fdb\u884c\u80be\u79d1\u53ca\u76f8\u5173\u75be\u75c5\u9886\u57df\u836f\u7269\u7684\u7814\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\uff0c\u81f4\u529b\u4e8e\u63d0\u4f9b\u56fd\u9645\u9886\u5148\u7684\u521b\u65b0\u6cbb\u7597\u53ca\u4e34\u5e8a\u89e3\u51b3\u65b9\u6848\uff0c\u4ee5\u5ef6\u7eed\u60a3\u8005\u7684\u751f\u547d\u4ee5\u53ca\u521b\u9020\u66f4\u4f18\u8d28\u7684\u5065\u5eb7\u751f\u6d3b\u3002<\/p>\n

\n

\"\"<\/a>
<\/span><\/p>\n<\/p><\/div>\n

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\u6162\u6027\u80be\u75c5\u5728\u4e2d\u56fd\u6210\u5e74\u4eba\u4e2d\u5e76\u4e0d\u5c11\u89c1\u3002\u6839\u636e\u73b0\u6709\u6d41\u884c\u75c5\u5b66\u8c03\u67e5\u8d44\u6599\u663e\u793a\uff0c\u4e2d\u56fd\u6210\u5e74\u4eba\u7fa4\u6162\u6027\u80be\u810f\u75c5\u60a3\u75c5\u7387\u9ad8\u8fbe10.8%\uff0c\u60a3\u8005\u4eba\u6570\u5c06\u8fd11.2\u4ebf\u3002\u5728\u4e2d\u56fd\uff0c\u6bcf\u5e74IgA\u80be\u75c5\u7684\u53d1\u75c5\u4eba\u6570\u57287\u4e07\u5de6\u53f3\u3002IgA\u80be\u75c5\u5728\u4e9a\u6d32\u4eba\u4e2d\u7684\u53d1\u75c5\u7387\u8981\u660e\u663e\u9ad8\u4e8e\u6b27\u7f8e\u4eba\u7fa4\u3002\u76ee\u524d\uff0c\u60a3\u8005\u53ea\u80fd\u957f\u671f\u4f7f\u7528\u57fa\u7840\u7684\u80be\u7d20-\u8840\u7ba1\u7d27\u5f20\u7d20\u7cfb\u7edf\uff08RAS\uff09\u6291\u5236\u5242\u6cbb\u7597\uff0c\u7597\u6548\u4e0d\u5c3d\u5982\u4eba\u610f\uff0c\u4f9d\u7136\u6709\u5927\u91cf\u60a3\u8005\u5728\u786e\u8bca\u540e\u768410-20\u5e74\u95f4\u8fdb\u5c55\u4e3a\u7ec8\u672b\u671f\u80be\u75c5\uff0c\u9700\u8981\u7ec8\u5e74\u900f\u6790\u6216\u80be\u810f\u79fb\u690d\u6cbb\u7597\u3002\u5168\u7403\u8303\u56f4\u5185IgA\u80be\u75c5\u5c1a\u65e0\u83b7\u6279\u7684\u9488\u5bf9\u6027\u836f\u7269\uff0c\u56e0\u6b64\u5728\u4e34\u5e8a\u4e0a\u4ecd\u7136\u5b58\u5728\u5de8\u5927\u7684\u672a\u6ee1\u8db3\u9700\u6c42\u3002<\/p>\n

Atrasentan\u662f\u4e00\u6b3e\u9009\u62e9\u6027\u5185\u76ae\u7d20\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u76ee\u524d\u6b63\u5904\u4e8e\u5168\u7403\u4e34\u5e8aIII\u671f\u8bd5\u9a8c\uff0c\u4ee5\u8bc4\u4f30\u5176\u5728IgA\u80be\u75c5\u7684\u6cbb\u7597\u7597\u6548\u3002\u5728\u6b64\u524d\u8fdb\u884c\u7684\u4e00\u9879\u67095,600\u591a\u540d\u60a3\u8005\u53c2\u52a0\u7684\u5168\u7403\u5927\u578b\u7cd6\u5c3f\u75c5\u80be\u75c5\u4e34\u5e8aIII\u671f\u7814\u7a76\u4e2d\u53d1\u73b0\uff0c\u5728\u7a33\u5b9a\u5242\u91cfRAS\u6291\u5236\u5242\u7684\u6cbb\u7597\u80cc\u666f\u4e0b\uff0c\u63a5\u53d7atrasentan\u6cbb\u7597\u540e\uff0c\u6709\u534a\u6570\u4ee5\u4e0a\u60a3\u8005\u7684\u86cb\u767d\u5c3f\u6709\u8d85\u8fc730%\u7684\u4e0b\u964d\uff0c\u5728\u8fd9\u4e9b\u60a3\u8005\u5e73\u57472\u5e74\u591a\u7684\u6cbb\u7597\u968f\u8bbf\u540e\uff0c\u6cbb\u7597\u7ec4\u6bcf\u5e74eGFR\u7684\u4e0b\u964d\u548c\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\u660e\u663e\u51cf\u7f13\u4e14\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u3002\u82e5atrasentan\u6210\u529f\u4e0a\u5e02\uff0c\u4e0e\u6807\u51c6\u7597\u6cd5RAS\u8054\u7528\uff0c\u5c06\u4e3aIgA\u80be\u75c5\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u5e76\u6709\u6f5c\u529b\u6210\u4e3a\u5355\u7528RAS\u65e0\u6548\u540e\u7684\u9996\u9009\u7597\u6cd5\uff0c\u5e02\u573a\u524d\u666f\u5e7f\u9614\u3002<\/p>\n

BION-1301\u4f5c\u4e3a\u4e00\u79cd\u6297APRIL\u5355\u6297\uff0c\u76ee\u524d\u5904\u4e8e\u9488\u5bf9IgA\u80be\u75c5\u7597\u6548\u8bc4\u4f30\u7684I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u3002\u5728\u6b64\u524d\u521a\u7ed3\u675f\u7684\u7f8e\u56fd\u80be\u810f\u75c5\u5b66\u4f1a\u4f1a\u8bae\uff08ASN\uff09\u4e0a\uff0cChinook\u516c\u5e03\u4e86\u8fd9\u9879I\/II\u671f\u8bd5\u9a8c\u7684\u6700\u65b0\u4e2d\u671f\u6570\u636e\u3002\u5728\u63a5\u53d7BION-1301\u9759\u8109\u6ce8\u5c04\uff08450mg\/\u6bcf2\u5468\uff09\u5f00\u653e\u6807\u7b7e\u6cbb\u7597\u7684IgA\u60a3\u8005\u4e2d\uff0c\u67094\u4f8b\u5b8c\u6210\u4e866\u4e2a\u6708\u6cbb\u7597\u3002\u6570\u636e\u663e\u793a\uff0c\u86cb\u767d\u5c3f\u4e0e\u57fa\u7ebf\u76f8\u6bd4\u4e0b\u964d\u7a0b\u5ea6\u7ea660%\uff0c\u6b64\u5916IgA\u548c\u81f4\u75c5\u6027gd-IgA1\u4e5f\u670970%-80%\u7684\u4e0b\u964d\u3002\u60a3\u8005\u5bf9BION-1301\u8010\u53d7\u6027\u826f\u597d\uff0c\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u6ca1\u6709\u53d1\u751f\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002\u6570\u636e\u663e\u793a\uff0cBION-1301\u6709\u5e0c\u671b\u6210\u4e3a\u53ef\u4ee5\u6539\u53d8IgA\u80be\u75c5\u75be\u75c5\u8fdb\u7a0b\u7684\u4e00\u6b3e\u521b\u65b0\u836f\u7269\uff0c\u4ece\u800c\u6539\u53d8\u76ee\u524dIgA\u80be\u75c5\u65e0\u836f\u53ef\u6cbb\u6108\u7684\u683c\u5c40\u3002<\/p>\n

\u201c\u6211\u4eec\u975e\u5e38\u6fc0\u52a8\u4e0eFrazier\u4ee5\u53caChinook\u5728\u4e2d\u56fd\u5171\u540c\u6210\u7acbSanReno\uff0c\u501f\u6b64\u5f00\u59cb\u63a2\u7d22atrasentan\u548cBION-1301\u8fd9\u4e24\u6b3e\u836f\u7269\u5728\u4e2d\u56fd\u7684\u5de8\u5927\u4e34\u5e8a\u6cbb\u7597\u6f5c\u529b\u3002\u201d<\/span>\u9f0e\u4e30\u751f\u79d1\u8d44\u672c\u5408\u4f19\u4eba\u94b1\u6676\u5973\u58eb\u8868\u793a\uff0c\u201c\u4e2d\u56fd\u5728\u80be\u75c5\u9886\u57df\u5b58\u5728\u5de8\u5927\u7684\u672a\u6ee1\u8db3\u533b\u7597\u9700\u6c42\u3002\u6211\u4eec\u5e0c\u671b\u4e0e\u62e5\u6709\u5171\u540c\u4ef7\u503c\u89c2\u7684\u5408\u4f5c\u4f19\u4f34\u643a\u624b\uff0c\u4e3a\u4e07\u5343\u80be\u79d1\u60a3\u8005\u5e26\u6765\u56fd\u9645\u6700\u65b0\u6cbb\u7597\u65b9\u5f0f\uff0c\u51cf\u8f7b\u4ed6\u4eec\u7684\u75c5\u75db\u548c\u751f\u6d3b\u8d1f\u62c5\u3002\u201d<\/p>\n

\u201c\u4e0e\u6211\u4eec\u7684\u5408\u4f5c\u4f19\u4f34\u9f0e\u4e30\u751f\u79d1\u8d44\u672c\u548cChinook\u4e00\u8d77\u5c06\u6709\u6700\u4f73\u6f5c\u529b\u7684\u80be\u79d1\u836f\u7269\u5e26\u6765\u4e2d\u56fd\uff0c\u7f13\u89e3\u90a3\u4e9b\u6b63\u53d7\u4e25\u91cd\u80be\u75c5\u6240\u82e6\u60a3\u8005\u7684\u75c5\u75db\uff0cFrazier\u89c9\u5f97\u975e\u5e38\u6fc0\u52a8\u3002\u201d Frazier\u7684\u8463\u4e8b\u603b\u7ecf\u7406Patrick Heron\u5148\u751f\u8868\u793a\uff0c\u201c\u4f9d\u6258Frazier\u8fc7\u53bb\u6210\u529f\u7684\u6295\u8d44\u5c65\u5386\u4ee5\u53ca\u9f0e\u4e30\u751f\u79d1\u8d44\u672c\u5728\u4e2d\u56fd\u751f\u7269\u79d1\u6280\u9886\u57df\u5b75\u5316\u4f01\u4e1a\u7684\u6df1\u539a\u7ecf\u9a8c\uff0c\u76f8\u4fe1SanReno\u5728\u672a\u6765\u4f1a\u6210\u957f\u4e3a\u4e00\u5bb6\u4f18\u79c0\u7684\u4f01\u4e1a\uff0c\u4e3a\u80be\u75c5\u60a3\u8005\u521b\u9020\u4ef7\u503c\u3002\u201d<\/p>\n

Chinook\u7684\u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98Eric Dobmeier\u5148\u751f\u8868\u793a\uff1a\u201c\u901a\u8fc7SanReno\u7684\u521b\u7acb\uff0cChinook\u53ef\u4ee5\u501f\u673a\u6269\u5927\u6211\u4eec\u7684\u5168\u7403\u5f71\u54cd\u529b\uff0c\u5e76\u4e14\u52a0\u5febatrasentan\u4e0eBION-1301\u5728\u5f53\u5730\u7684\u6ce8\u518c\u548c\u5ba1\u6279\u3002\u540c\u65f6\u65b0\u516c\u53f8\u7684\u6210\u7acb\u4e5f\u662f\u6211\u4eec\u4f01\u4e1a\u4f7f\u547d\u7684\u8df5\u884c\uff0c\u90a3\u5c31\u662f\u5e0c\u671b\u5168\u7403\u7684\u80be\u75c5\u60a3\u8005\u4e0d\u518d\u9700\u8981\u900f\u6790\u548c\u79fb\u690d\u3002\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

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