{"id":54730,"date":"2021-12-01T07:00:00","date_gmt":"2021-12-01T00:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021120107000054730"},"modified":"2021-12-01T17:53:52","modified_gmt":"2021-12-01T09:53:52","slug":"%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%af%e5%92%8c%e4%bf%a1%e8%be%be%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e4%b8%ad%e5%9b%bd%e9%a6%96%e4%b8%aa%e4%b8%89%e4%bb%a3bcr-abl-tki%e8%8e%b7%e6%89%b9%ef%bc%81%e8%80%90","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021120107000054730","title":{"rendered":"\u4e9a\u76db\u533b\u836f\u548c\u4fe1\u8fbe\u751f\u7269\u5ba3\u5e03\u4e2d\u56fd\u9996\u4e2a\u4e09\u4ee3BCR-ABL TKI\u83b7\u6279\uff01\u8010\u7acb\u514b\u00ae\u5f00\u542f\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\u6cbb\u7597\u65b0\u65f6\u4ee3"},"content":{"rendered":"<p><p>\u4e2d\u56fd\u82cf\u5dde\u548c\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e022021\u5e7412\u6708<span id=\"spanHghltfab8\">1<\/span>\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u81f4\u529b\u4e8e\u5728\u80bf\u7624\u3001\u4e59\u809d\u53ca\u4e0e\u8870\u8001\u76f8\u5173\u75be\u75c5\u7b49\u6cbb\u7597\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\u2014\u2014\u4e9a\u76db\u533b\u836f\uff086855.HK\uff09\uff0c\u4e0e\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3001\u4ee3\u8c22\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u7b49\u91cd\u5927\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u5171\u540c\u5ba3\u5e03\uff0c\u4e9a\u76db\u533b\u836f\u5168\u8d44\u5b50\u516c\u53f8\u5e7f\u5dde\u987a\u5065\u751f\u7269\u533b\u836f\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0\u987a\u5065\u533b\u836f\uff09\u7684\u539f\u521b1\u7c7b\u65b0\u836f\u5965\u96f7\u5df4\u66ff\u5c3c\u7247\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b<sup>&reg;<\/sup>\uff09\u6b63\u5f0f\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u7684\u4e0a\u5e02\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u4efb\u4f55\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08TKI\uff09\u8010\u836f\uff0c\u5e76\u91c7\u7528\u7ecf\u5145\u5206\u9a8c\u8bc1\u7684\u68c0\u6d4b\u65b9\u6cd5\u8bca\u65ad\u4e3a\u4f34\u6709T315I\u7a81\u53d8\u7684\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\uff08CML\uff09\u6162\u6027\u671f\uff08CP\uff09\u6216\u52a0\u901f\u671f\uff08AP\uff09\u7684\u6210\u5e74\u60a3\u8005\u3002<\/p>\n<p>\u8010\u7acb\u514b<sup>&reg;<\/sup>\u662f\u4e9a\u76db\u533b\u836f\u7814\u53d1\u7684\u6f5c\u5728\u540c\u7c7b\u6700\u4f73\uff08Best-in-class\uff09\u65b0\u836f\uff0c\u4e3a\u56fd\u5bb6\u201c\u91cd\u5927\u65b0\u836f\u521b\u5236<span id=\"spanHghlt731a\">\u201d<\/span>\u4e13\u9879\u652f\u6301\u54c1\u79cd\u3002\u8be5\u54c1\u79cd\u5c06\u7531\u4e9a\u76db\u533b\u836f\u4e0e\u4fe1\u8fbe\u751f\u7269\u5171\u540c\u5728\u4e2d\u56fd\u5f00\u5c55\u5546\u4e1a\u5316\u63a8\u5e7f\uff0c\u4ee5\u60e0\u53ca\u66f4\u591a\u60a3\u8005\u53ca\u5176\u5bb6\u5ead\u3002<b>\u4f5c\u4e3a<\/b><b>\u4e2d\u56fd\u9996\u4e2a\u4e09\u4ee3<\/b><b>BCR-ABL<\/b><b>\u9776\u5411\u8010\u836f<\/b><b>CML<\/b><b>\u6cbb\u7597\u836f\u7269\uff0c\u8010\u7acb\u514b<\/b><b><sup>&reg;<\/sup><\/b><b>\u7684\u83b7\u6279\u5c06\u6253\u7834\u4e2d\u56fd\u643a<\/b><b>T315I<\/b><b>\u7a81\u53d8\u8010\u836f\u60a3\u8005\u7684\u6cbb\u7597\u74f6\u9888\uff0c\u89e3\u51b3\u65e0\u836f\u53ef\u533b\u7684\u56f0\u5883\u3002\u5176\u83b7\u6279\u4e5f\u6807\u5fd7\u7740\u4e9a\u76db\u533b\u836f\u6b63\u5f0f\u6b65\u5165\u5546\u4e1a\u5316\u9636\u6bb5\u3002<\/b><\/p>\n<p>\u8010\u7acb\u514b<sup>&reg;<\/sup>\u83b7\u6279\u4e3b\u8981\u57fa\u4e8e\u4e24\u9879\u5173\u952e\u6027\u6ce8\u518cII\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff0c\u5206\u522b\u4e3aHQP1351CC201\u7814\u7a76\u3001HQP1351CC202\u7814\u7a76\u3002\u4e34\u5e8a\u6570\u636e<b>\u663e\u793a\u8010\u7acb\u514b<\/b><b><sup>&reg;<\/sup><\/b><b>\u5728\u4f34\u6709<\/b><b>T315I<\/b><b>\u7a81\u53d8\u7684<\/b><b>TKI<\/b><b>\u8010\u836f\u7684<\/b><b>CML-CP<\/b><b>\u53ca<\/b><b>CML-AP<\/b><b>\u60a3\u8005\u4e2d\u5747\u5177\u6709\u826f\u597d\u7684\u7597\u6548\u53ca\u8010\u53d7\u6027\uff0c\u4e14\u968f\u7740\u6cbb\u7597\u65f6\u95f4\u7684\u5ef6\u957f\uff0c\u7f13\u89e3\u7387\u548c\u7f13\u89e3\u6df1\u5ea6\u4f1a\u8fdb\u4e00\u6b65\u589e\u52a0\u3002<\/b><\/p>\n<p>CML\u662f\u4e00\u79cd\u4e0e\u767d\u7ec6\u80de\u6709\u5173\u7684\u6076\u6027\u80bf\u7624\u3002\u968f\u7740\u9776\u5411BCR-ABL\u7684TKI\u836f\u7269\u4e0a\u5e02\uff0c\u9488\u5bf9CML\u7684\u6cbb\u7597\u65b9\u5f0f\u5f97\u4ee5\u9769\u65b0\uff0c<b>\u4f46\u83b7\u5f97\u6027\u8010\u836f\u4e00\u76f4\u662f<\/b><b>CML<\/b><b>\u6cbb\u7597\u7684\u4e3b\u8981\u6311\u6218\u3002<\/b>BCR-ABL\u6fc0\u9176\u533a\u7a81\u53d8\u662f\u83b7\u5f97\u6027\u8010\u836f\u7684\u91cd\u8981\u673a\u5236\u4e4b\u4e00\uff0c\u5176\u4e2dT315I\u7a81\u53d8\u662f\u5e38\u89c1\u7684\u8010\u836f\u7a81\u53d8\u7c7b\u578b\u4e4b\u4e00\uff0c\u5728\u8010\u836fCML\u4e2d\u7684\u53d1\u751f\u7387\u9ad8\u8fbe25%\u5de6\u53f3\u3002<b>\u4f34\u6709<\/b><b>T315I<\/b><b>\u7a81\u53d8\u7684<\/b><b>CML<\/b><b>\u60a3\u8005\u5bf9\u76ee\u524d\u6240\u6709\u4e00\u4ee3\u3001\u4e8c\u4ee3<\/b><b>BCR-ABL<\/b><b>\u6291\u5236\u5242\u5747\u8010\u836f\uff0c\u56e0\u6b64\u5728\u8fc7\u53bb\u4e00\u76f4\u9762\u4e34\u65e0\u836f\u53ef\u533b\u7684\u7a98\u5883\u3002<\/b><\/p>\n<p><b>\u8010\u7acb\u514b<\/b><b><sup>&reg;<\/sup><\/b><b>\u4e2d\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u4e3b\u8981\u7814\u7a76\u8005<\/b><b>\u3001<\/b><b>\u5317\u4eac\u5927\u5b66\u8840\u6db2\u75c5\u7814\u7a76\u6240\u6240\u957f\u3001\u5317\u4eac\u5927\u5b66\u4eba\u6c11\u533b\u9662\u8840\u6db2\u79d1\u4e3b\u4efb\u9ec4\u6653\u519b\u6559\u6388<\/b>\u8868\u793a\uff1a\u201c\u8fc7\u5f80\u4e34\u5e8a\u7814\u7a76\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u6570\u636e\u4e0d\u65ad\u5411\u6211\u4eec\u663e\u793a\uff0c\u8010\u7acb\u514b<sup>&reg;<\/sup>\u5728\u8010\u836f\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\u8fd9\u4e2a\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u9886\u57df\u6f5c\u529b\u5de8\u5927\uff0c\u6781\u6709\u5e0c\u671b\u6210\u4e3a\u8be5\u9886\u57df\u6cbb\u7597\u7684\u2018Best-in-Class\u2019\u836f\u7269\u3002\u8fd1\u51e0\u5e74\u6765\uff0c\u8fd9\u4e00\u836f\u7269\u7684\u4e34\u5e8a\u8fdb\u5c55\u4e5f\u4e0d\u65ad\u53d7\u5230\u5168\u7403\u8840\u6db2\u5b66\u754c\u7684\u5173\u6ce8\u3002\u5f88\u9ad8\u5174\u770b\u5230\u8010\u7acb\u514b<sup>&reg;<\/sup>\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\u3002\u8fd9\u4e0d\u4ec5\u610f\u5473\u7740\u4e2d\u56fd\u7684CML\u6cbb\u7597\u6253\u7834\u4e86\u539f\u6709\u7684\u8010\u836f\u56f0\u5883\u3001\u8fce\u6765\u4e86\u5168\u65b0\u7684\u91cc\u7a0b\u7891\uff1b\u66f4\u610f\u5473\u7740\u4e2d\u56fd\u5728\u8840\u6db2\u80bf\u7624\u9886\u57df\u7684\u4e34\u5e8a\u5b9e\u529b\u6b63\u9010\u6e10\u8d70\u5411\u4e16\u754c\u524d\u6cbf\u3002<span id=\"spanHghlt731a\">\u201d<\/span><\/p>\n<p><b>\u8010\u7acb\u514b<\/b><b><sup>&reg;<\/sup><\/b><b>\u4e2d\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u4e3b\u8981\u7814\u7a76\u8005\u3001\u5317\u4eac\u5927\u5b66\u4eba\u6c11\u533b\u9662\u8840\u6db2\u79d1\u526f\u4e3b\u4efb\u6c5f\u5029\u6559\u6388<\/b>\u8868\u793a\uff1a\u201cCML-CP\u53caCML-AP\u60a3\u8005\u4e00\u65e6\u51fa\u73b0T315I\u7a81\u53d8\uff0c\u6240\u6709\u7684\u4e00\u4ee3\u6216\u4e8c\u4ee3TKI\u5bf9\u8fd9\u4e9b\u60a3\u8005\u90fd\u65e0\u6548\u3002\u5728\u4eca\u5929\u4e4b\u524d\uff0c\u8fd9\u90fd\u662f\u4e00\u4e2a\u4e34\u5e8a\u9700\u6c42\u9ad8\u5ea6\u672a\u88ab\u6ee1\u8db3\u7684\u9886\u57df\u3002\u800c\u8010\u7acb\u514b<sup>&reg;<\/sup>\u7684\u83b7\u6279\u5c06\u89e3\u5f00\u8fd9\u4e00\u65e0\u836f\u53ef\u533b\u7684\u56f0\u5c40\uff0c\u5bf9\u4e34\u5e8a\u533b\u751f\u548c\u60a3\u8005\u7684\u610f\u4e49\u5de8\u5927\u3002\u76f8\u4fe1\u968f\u7740\u8fd9\u4e00\u836f\u7269\u7684\u4e0a\u5e02\uff0c\u66f4\u591aCML\u60a3\u8005\u80fd\u591f\u5ef6\u7eed\u751f\u547d\u7684\u7cbe\u5f69\u3002<span id=\"spanHghlt731a\">\u201d<\/span><\/p>\n<p><b>\u4e9a\u76db\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98\uff0c\u987a\u5065\u533b\u836f\u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb<\/b>\u8868\u793a\uff1a\u201c\u611f\u8c22\u5404\u7ea7\u836f\u76d1\u90e8\u95e8\u548c\u76f8\u5173\u673a\u6784\u5bf9\u8010\u836fCML\u60a3\u8005\u6cbb\u7597\u9700\u6c42\u7684\u9ad8\u5ea6\u5173\u6ce8\uff0c\u4ee5\u53ca\u5bf9\u4e2d\u56fd\u672c\u571f\u521b\u65b0\u836f\u53d1\u5c55\u7684\u5927\u529b\u652f\u6301\uff01\u611f\u8c22\u4f17\u591a\u4e34\u5e8a\u4e13\u5bb6\u4e0e\u60a3\u8005\u7684\u503e\u60c5\u4ed8\u51fa\u4e0e\u5145\u5206\u4fe1\u4efb\uff01\u611f\u8c22\u6211\u4eec\u56e2\u961f\u6210\u5458\u7684\u575a\u5b88\uff0c\u7279\u522b\u662f\u5728\u75ab\u60c5\u4e0b\u80fd\u514b\u670d\u5404\u79cd\u524d\u6240\u672a\u6709\u7684\u6311\u6218\u4e0e\u56f0\u96be\uff01\u6b64\u6b21\u8010\u7acb\u514b&reg;\u7684\u83b7\u6279\u4e0a\u5e02\u610f\u4e49\u975e\u51e1\uff0c\u4f5c\u4e3a\u4e2d\u56fd\u9996\u4e2a\u3001\u5168\u7403\u7b2c\u4e8c\u4e2a\u83b7\u6279\u4e0a\u5e02\u7684\u4e09\u4ee3BCR-ABL\u6291\u5236\u5242\uff0c\u5b83\u4e0d\u4ec5\u80fd\u6539\u53d8\u4e2d\u56fd\u643aT315I\u7a81\u53d8\u8010\u836f\u60a3\u8005\u65e0\u836f\u53ef\u533b\u7684\u73b0\u72b6\uff0c\u4e5f\u6709\u671b\u586b\u8865\u5168\u7403CML\u6cbb\u7597\u672a\u88ab\u6ee1\u8db3\u7684\u4e34\u5e8a\u7a7a\u767d\u3002\u201d<\/p>\n<p><b>\u4e9a\u76db\u533b\u836f\u8463\u4e8b\u957f\u3001<\/b><b>CEO<\/b><b>\u6768\u5927\u4fca\u535a\u58eb<\/b>\u8868\u793a\uff1a\u201c\u4f5c\u4e3a\u516c\u53f8\u7684\u7b2c\u4e00\u4e2a\u5546\u4e1a\u5316\u4ea7\u54c1\uff0c\u8010\u7acb\u514b<sup>&reg;<\/sup>\u7684\u83b7\u6279\u65e0\u7591\u662f\u91cd\u5927\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff0c\u610f\u5473\u7740\u4e9a\u76db\u533b\u836f\u4ece\u7814\u53d1\u578b\u516c\u53f8\u5230\u6709\u4ea7\u54c1\u4e0a\u5e02\u7684\u516c\u53f8\u7684\u6210\u529f\u8de8\u8d8a\uff0c\u4e3a\u6211\u4eec\u5e26\u6765\u4e86\u6781\u5927\u7684\u4fe1\u5fc3\u3002\u6211\u4eec\u5c06\u4e0e\u4fe1\u8fbe\u751f\u7269\u901a\u529b\u5408\u4f5c\uff0c\u5168\u9762\u63d0\u901f\u5546\u4e1a\u5316\u5e03\u5c40\u3002\u6b64\u5916\u3002\u6211\u4eec\u6b63\u79ef\u6781\u63a8\u8fdb\u4e0e\u57fa\u56e0\u68c0\u6d4b\u516c\u53f8\u3001\u5546\u4e1a\u4fdd\u9669\u516c\u53f8\u3001\u4e92\u8054\u7f51\u533b\u836f\u7b49\u591a\u65b9\u7684\u5408\u4f5c\uff0c\u5e0c\u671b\u5c3d\u5feb\u5c06\u8fd9\u6b3e\u5168\u7403\u9886\u5148\u3001\u4e2d\u56fd\u539f\u521b\u7684\u4ea7\u54c1\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002\u6211\u4eec\u5c06\u59cb\u7ec8\u575a\u5b88\u5168\u7403\u521b\u65b0\u5b9a\u4f4d\uff0c\u8df5\u884c\u2018\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u2019\u7684\u4f7f\u547d\u2019\u3002\u672a\u6765\uff0c\u4e9a\u76db\u533b\u836f\u5c06\u8fdb\u4e00\u6b65\u8fdb\u884c\u8be5\u54c1\u79cd\u65b0\u9002\u5e94\u75c7\u7684\u62d3\u5c55\u4ee5\u53ca\u6d77\u5916\u4e34\u5e8a\u7684\u63a8\u8fdb\uff0c\u5e76\u7ee7\u7eed\u52a0\u901f\u516c\u53f8\u5176\u4ed6\u5728\u7814\u54c1\u79cd\u7684\u5168\u7403\u5f00\u53d1\uff0c\u771f\u6b63\u5b9e\u73b0\u2018\u4ece\u4e2d\u56fd\u8d70\u5411\u4e16\u754c\u2019\u3002\u201d <\/p>\n<p><b>\u4fe1\u8fbe\u751f\u7269\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u957f\u517c<\/b><b>CEO<\/b><b>\u4fde\u5fb7\u8d85\u535a\u58eb<\/b>\u8868\u793a\uff1a\u201c\u6211\u4eec\u5f88\u9ad8\u5174\u8010\u7acb\u514b<sup>&reg;<\/sup>\u5728\u4e2d\u56fd\u6210\u529f\u83b7\u6279\uff0c\u4e3a\u4fe1\u8fbe\u751f\u7269\u5728\u8840\u6db2\u7624\u9886\u57df\u7684\u6df1\u539a\u5e03\u5c40\u518d\u6dfb\u4e00\u6b3e\u65b0\u4e00\u4ee3\u6297\u80bf\u7624\u4ea7\u54c1\u3002\u4fe1\u8fbe\u751f\u7269\u5728\u6297\u80bf\u7624\u9886\u57df\u62e5\u6709\u96c4\u539a\u768420\u6b3e\u4e34\u5e8a\u9636\u6bb5\u7ba1\u7ebf\u3001\u4e1a\u5185\u9886\u5148\u7684\u4e34\u5e8a\u5f00\u53d1\u548c\u6ce8\u518c\u56e2\u961f\u3001\u5e7f\u9614\u7684\u5546\u4e1a\u6e20\u9053\u8986\u76d6\u53ca\u8fd13000\u4eba\u7684\u5546\u4e1a\u5316\u56e2\u961f\u3002\u6211\u4eec\u671f\u5f85\u4e0e\u4e9a\u76db\u533b\u836f\u5728\u8be5\u4ea7\u54c1\u7684\u4e2d\u56fd\u5e02\u573a\u8986\u76d6\u548c\u5546\u4e1a\u5316\u63a8\u5e7f\u4e0a\u7684\u7d27\u5bc6\u5408\u4f5c\uff0c\u5c3d\u5feb\u6ee1\u8db3TKI\u8010\u836fT315I\u7a81\u53d8\u7684CML\u60a3\u8005\u7684\u4e9f\u5f85\u6cbb\u7597\u7684\u4e34\u5e8a\u9700\u6c42\u3002\u201d<\/p>\n<p class=\"prntac\"><b>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;END&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/b><\/p>\n<p><b>\u5173\u4e8e\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5<\/b><\/p>\n<p>\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\uff08Chronic Myeloid Leukemia, CML\uff09\uff0c\u662f\u9aa8\u9ad3\u9020\u8840\u5e72\u7ec6\u80de\u514b\u9686\u6027\u589e\u6b96\u5f62\u6210\u7684\u6076\u6027\u80bf\u7624\uff0c\u4e5f\u88ab\u79f0\u4e3a\u6162\u6027\u7c92\u7ec6\u80de\u767d\u8840\u75c5\uff0c\u662f\u6162\u6027\u767d\u8840\u75c5\u4e2d\u6700\u5e38\u89c1\u7684\u4e00\u79cd\u7c7b\u578b\uff0c\u5360\u6210\u4eba\u767d\u8840\u75c5\u768415%<sup>[1]-[2]<\/sup>\u3002\u4e2d\u56fdCML\u60a3\u8005\u53d1\u75c5\u8f83\u897f\u65b9\u66f4\u4e3a\u5e74\u8f7b\u5316\uff0c\u6d41\u884c\u75c5\u5b66\u8c03\u67e5\u663e\u793a\uff0c\u4e2d\u56fdCML\u7684\u4e2d\u4f4d\u53d1\u75c5\u5e74\u9f84\u4e3a45~50\u5c81\uff0c\u897f\u65b9\u56fd\u5bb6CML\u7684\u4e2d\u4f4d\u53d1\u75c5\u5e74\u9f84\u4e3a67\u5c81<sup>[3]<\/sup>\u3002<\/p>\n<p>\u968f\u7740\u9776\u5411BCR-ABL\u7684TKI\u836f\u7269\u4e0a\u5e02\uff0c\u9488\u5bf9CML\u7684\u6cbb\u7597\u65b9\u5f0f\u5f97\u4ee5\u9769\u65b0\uff0c\u4f46\u83b7\u5f97\u6027\u8010\u836f\u4e00\u76f4\u662fCML\u6cbb\u7597\u7684\u4e3b\u8981\u6311\u6218\u3002BCR-ABL\u6fc0\u9176\u533a\u7a81\u53d8\u662f\u83b7\u5f97\u6027\u8010\u836f\u7684\u91cd\u8981\u673a\u5236\u4e4b\u4e00\uff0c\u5176\u4e2dT315I\u7a81\u53d8\u662f\u5e38\u89c1\u7684\u8010\u836f\u7a81\u53d8\u7c7b\u578b\u4e4b\u4e00\uff0c\u5728\u8010\u836fCML\u4e2d\u7684\u53d1\u751f\u7387\u9ad8\u8fbe25%\u5de6\u53f3\u3002\u4f34\u6709T315I\u7a81\u53d8\u7684CML\u60a3\u8005\u5bf9\u76ee\u524d\u6240\u6709\u4e00\u4ee3\u3001\u4e8c\u4ee3BCR-ABL\u6291\u5236\u5242\u5747\u8010\u836f\uff0c\u5728\u8fc7\u53bb\u4e00\u76f4\u662fCML\u60a3\u8005\u7fa4\u4f53\u957f\u671f\u751f\u5b58\u7684\u963b\u788d\u3002<\/p>\n<p><b>\u5173\u4e8e\u8010\u7acb\u514b<\/b><b><sup>&reg;<\/sup><\/b><\/p>\n<p>\u8010\u7acb\u514b<sup>&reg;<\/sup>\u662f\u4e9a\u76db\u533b\u836f\u539f\u521b1\u7c7b\u65b0\u836f\uff0c\u4e3a\u53e3\u670d\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5242\uff0c\u662f\u4e2d\u56fd\u9996\u4e2a\u83b7\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u9776\u5411\u8010\u836fCML\u6cbb\u7597\u836f\u7269\uff0c\u5bf9BCR-ABL\u4ee5\u53ca\u5305\u62ecT315I\u7a81\u53d8\u5728\u5185\u7684\u591a\u79cdBCR-ABL\u7a81\u53d8\u4f53\u6709\u7a81\u51fa\u6548\u679c\uff0c\u83b7\u56fd\u5bb6\u201c\u91cd\u5927\u65b0\u836f\u521b\u5236\u201c\u4e13\u9879\u652f\u6301\u3002<\/p>\n<p>2020\u5e7410\u6708\uff0c\u8010\u7acb\u514b<sup>&reg;<\/sup>\u88abNMPA\u65b0\u836f\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\uff0c\u7528\u4e8e\u6cbb\u7597TKI\u8010\u836f\u540e\u5e76\u4f34\u6709T315I\u7a81\u53d8\u7684CML\u6162\u6027\u671f\u6216\u52a0\u901f\u671f\u7684\u6210\u5e74\u60a3\u8005\uff1b2021\u5e743\u6708\uff0c\u8be5\u54c1\u79cd\u88abCDE\u7eb3\u5165\u7a81\u7834\u6027\u6cbb\u7597\u54c1\u79cd\u3002\u800c\u5728\u6d77\u5916\uff0c\u8be5\u54c1\u79cd\u4e8e2019\u5e747\u6708\u83b7FDA\u4e34\u5e8a\u8bd5\u9a8c\u8bb8\u53ef\uff0c\u76f4\u63a5\u8fdb\u5165Ib\u671f\u4e34\u5e8a\u7814\u7a76\uff1b2020\u5e745\u6708\u63a5\u8fde\u83b7\u5f97\u7f8e\u56fdFDA\u6388\u4e88\u7684\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u548c\u5ba1\u8bc4\u5feb\u901f\u901a\u9053\u8d44\u683c\uff1b2021\u5e7411\u6708\u83b7\u6b27\u76df\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\uff1b\u6b64\u5916\uff0c\u8be5\u54c1\u79cd\u7684\u4e34\u5e8a\u8bd5\u9a8c\u8fdb\u5c55\u81ea2018\u5e74\u5f00\u59cb\uff0c\u8fde\u7eed\u56db\u5e74\u5165\u9009\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08ASH\uff09\u5e74\u4f1a\u53e3\u5934\u62a5\u544a\uff0c\u5e76\u8363\u83b72019 ASH\u5e74\u4f1a\u201c\u6700\u4f73\u7814\u7a76\u201d\u7684\u63d0\u540d\u3002<\/p>\n<p>2021\u5e747\u6708\uff0c\u4e9a\u76db\u533b\u836f\u4e0e\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff081801.HK\uff09\u8fbe\u6210\u5728\u4e2d\u56fd\u5e02\u573a\u5c31\u8010\u7acb\u514b&reg;\u5171\u540c\u5f00\u53d1\u548c\u5171\u540c\u5546\u4e1a\u5316\u63a8\u5e7f\u7684\u6218\u7565\u5408\u4f5c\u3002<\/p>\n<p><i>*<\/i><i>\u6ce8<\/i><i>&nbsp;<\/i><i>\u8010\u7acb\u514b<\/i><i><sup>&reg;<\/sup><\/i><i>\u4e3a\u4e9a\u76db\u533b\u836f\u7684\u6ce8\u518c\u5546\u6807<\/i><\/p>\n<p><b>\u5173\u4e8e\u4e24\u9879\u5173\u952e\u6027\u6ce8\u518c<\/b><b>II<\/b><b>\u671f\u4e34\u5e8a\u7814\u7a76<\/b><\/p>\n<p><u>\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\u2014\u2014\u6162\u6027\u671f\u60a3\u8005<\/u><u>&nbsp;<\/u><u>HQP1351CC201<\/u><u>\u7814\u7a76<\/u><\/p>\n<ul type=\"disc\">\n<li>HQP1351CC201\u662f\u4e00\u9879\u5f00\u653e\u3001\u591a\u4e2d\u5fc3\u3001\u5355\u81c2\u8bbe\u8ba1\u7684II \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u5bf9\u5965\u96f7\u5df4\u66ff\u5c3c\u7247\u6cbb\u7597\u4efb\u4f55\u9776\u5411BCR-ABL1 \u7684TKI\u6cbb\u7597\u540e\u51fa\u73b0T315I \u7a81\u53d8\u7684CML-CP\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u8fdb\u884c\u8bc4\u4ef7\u3002\u8be5\u9879\u8bd5\u9a8c\u7684\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u4e3a\u4e3b\u8981\u7ec6\u80de\u9057\u4f20\u5b66\u7f13\u89e3\uff08MCyR\uff09\u3002 <\/li>\n<li>\u622a\u81f32020\u5e748\u670825\u65e5\uff0c\u5965\u96f7\u5df4\u66ff\u5c3c\u5728CML-CP\u60a3\u8005\u4e2d\u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f413.0\u4e2a\u6708\uff08\u8303\u56f4\uff1a7.2- 16.3\uff09\u300231\u4f8b\u8840\u6db2\u5b66\u53cd\u5e94\u53ef\u8bc4\u4f30\u53d7\u8bd5\u8005\u4e2d\uff0c31\u4f8b\uff08100%\uff09\u83b7\u5f97\u5b8c\u5168\u8840\u6db2\u5b66\u53cd\u5e94\uff08CHR\uff09\uff1b41\u4f8b\u7ec6\u80de\u9057\u4f20\u5b66\u53ef\u8bc4\u4f30\u53d7\u8bd5\u8005\u4e2d\uff0c31\u4f8b\uff0875.6 %\uff09\u83b7\u5f97\u4e3b\u8981\u7ec6\u80de\u9057\u4f20\u5b66\u53cd\u5e94\uff08MCyR\uff09\uff0c\u5305\u62ec28\u4f8b\uff0868.3%\uff09\u5b8c\u5168\u7ec6\u80de\u9057\u4f20\u5b66\u53cd\u5e94\uff08CCyR\uff09\u548c3\u4f8b\uff087.3%\uff09\u90e8\u5206\u7ec6\u80de\u9057\u4f20\u5b66\u53cd\u5e94\uff08PCyR\uff09\uff1b41\u4f8b\u5206\u5b50\u5b66\u53cd\u5e94\u53ef\u8bc4\u4f30\u7684\u53d7\u8bd5\u8005\u4e2d\uff0c23\u4f8b\uff0856.1%\uff09\u83b7\u5f97\u4e3b\u8981\u5206\u5b50\u5b66\u53cd\u5e94\uff08MMR\uff09\u300212\u4e2a\u6708\u65e0\u8fdb\u5c55\u751f\u5b58\uff08PFS\uff09\u7387\u4e3a85.7%\uff0895% CI\uff1a[63.6% &#8211; 94.9%]\uff09\uff0c\u603b\u4f53\u751f\u5b58\uff08OS\uff09\u7387\u4e3a100%\uff0895% CI\uff1a[100.0% -100.0%]\uff09\u3002<\/li>\n<\/ul>\n<p><u>\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\u2014\u2014\u52a0\u901f\u671f\u60a3\u8005<\/u><u>HQP1351CC202 <\/u><u>\u7814\u7a76<\/u><\/p>\n<ul type=\"disc\">\n<li>HQP1351CC202\u662f\u5728\u4e00\u9879\u5f00\u653e\u3001\u591a\u4e2d\u5fc3\u3001\u5355\u81c2\u8bbe\u8ba1\u7684II \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u5bf9\u5965\u96f7\u5df4\u66ff\u5c3c\u7247\u6cbb\u7597\u4efb\u4f55\u9776\u5411BCR-ABL1\u7684TKI\u6cbb\u7597\u540e\u51fa\u73b0\u9488\u5bf9TKI\u8010\u836f\u4f34\u6709T315I\u7a81\u53d8\u7684CML-AP\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u8fdb\u884c\u8bc4\u4ef7\u3002\u8be5\u9879\u8bd5\u9a8c\u7684\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u4e3a\u4e3b\u8981\u8840\u6db2\u5b66\u53cd\u5e94\u7387\uff08MaHR\uff09\u3002 <\/li>\n<li>\u622a\u81f32020\u5e747\u670827\u65e5\uff0c\u5965\u96f7\u5df4\u66ff\u5c3c\u5728CML-AP\u60a3\u8005\u4e2d\u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f414.3\u4e2a\u6708\uff08\u8303\u56f4\uff1a6.6-15.2\uff09\u300217\u4f8b\u53ef\u8bc4\u4f30\u7684\u53d7\u8bd5\u8005\u4e2d\uff0c12\u4f8b\uff0870.6%\uff09\u83b7\u5f97\u4e3b\u8981\u8840\u6db2\u5b66\u53cd\u5e94\uff08MaHR\uff09\uff0c\u5305\u62ec11\u4f8b\uff0864.7%\uff09\u5b8c\u5168\u8840\u6db2\u5b66\u53cd\u5e94\uff08CHR\uff09\u548c1\u4f8b\uff085.9%\uff09\u65e0\u767d\u8840\u75c5\u8bc1\u636e\uff08NEL\uff09\u300217\u4f8b\u53ef\u8bc4\u4f30\u53d7\u8bd5\u8005\u4e2d\uff0c8\u4f8b\uff0847.1%\uff09\u83b7\u5f97\u4e3b\u8981\u7ec6\u80de\u9057\u4f20\u5b66\u53cd\u5e94\uff08MCyR\uff09\uff0c\u5305\u62ec8\u4f8b\uff0847.1%\uff09\u5b8c\u5168\u7ec6\u80de\u9057\u4f20\u5b66\u53cd\u5e94\uff08CCyR\uff09\u300217\u4f8b\u53ef\u8bc4\u4f30\u7684\u53d7\u8bd5\u8005\u4e2d\uff0c7\u4f8b\uff0841.2%\uff09\u83b7\u5f97\u4e3b\u8981\u5206\u5b50\u5b66\u53cd\u5e94\uff08MMR\uff09\u300212\u4e2a\u6708\u7684PFS\u7387\u4e3a73.3%\uff0895% CI\uff1a[43.3% &#8211; 89.1%]\uff09\u300212\u4e2a\u6708OS\u4e3a88.2%\uff0895% CI\uff1a[60.6% -96.9%]\uff09\u3002<\/li>\n<\/ul>\n<p><b>\u5173\u4e8e\u4e9a\u76db\u533b\u836f<\/b><\/p>\n<p>\u4e9a\u76db\u533b\u836f\u662f\u4e00\u5bb6\u7acb\u8db3\u4e2d\u56fd\u3001\u9762\u5411\u5168\u7403\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\uff0c\u81f4\u529b\u4e8e\u5728\u80bf\u7624\u3001\u4e59\u809d\u53ca\u4e0e\u8870\u8001\u76f8\u5173\u7684\u75be\u75c5\u7b49\u6cbb\u7597\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u30022019\u5e7410\u670828\u65e5\uff0c\u4e9a\u76db\u533b\u836f\u5728\u9999\u6e2f\u8054\u4ea4\u6240\u4e3b\u677f\u6302\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a6855.HK\u3002<\/p>\n<p>\u4e9a\u76db\u533b\u836f\u62e5\u6709\u81ea\u4e3b\u6784\u5efa\u7684\u86cb\u767d-\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u9776\u5411\u836f\u7269\u8bbe\u8ba1\u5e73\u53f0\uff0c\u5904\u4e8e\u7ec6\u80de\u51cb\u4ea1\u901a\u8def\u65b0\u836f\u7814\u53d1\u7684\u5168\u7403\u6700\u524d\u6cbf\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u62e5\u67098\u4e2a\u5df2\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u76841\u7c7b\u5c0f\u5206\u5b50\u65b0\u836f\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u3001IAP \u6216&nbsp;MDM2-p53 \u7b49\u7ec6\u80de\u51cb\u4ea1\u8def\u5f84\u5173\u952e\u86cb\u767d\u7684\u6291\u5236\u5242\uff1b\u65b0\u4e00\u4ee3\u9488\u5bf9\u764c\u75c7\u6cbb\u7597\u4e2d\u51fa\u73b0\u7684\u6fc0\u9176\u7a81\u53d8\u4f53\u7684\u6291\u5236\u5242\u7b49\uff0c\u4e3a\u5168\u7403\u552f\u4e00\u5728\u7ec6\u80de\u51cb\u4ea1\u8def\u5f84\u5173\u952e\u86cb\u767d\u9886\u57df\u5747\u6709\u4e34\u5e8a\u5f00\u53d1\u54c1\u79cd\u7684\u521b\u65b0\u516c\u53f8\u3002\u76ee\u524d\u516c\u53f8\u6b63\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u53ca\u6b27\u6d32\u5f00\u5c5540\u591a\u9879I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u7528\u4e8e\u6cbb\u7597\u8010\u836f\u6027\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\u7684\u6838\u5fc3\u54c1\u79cd\u5965\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b<sup>&reg;<\/sup>\uff09\u66fe\u83b7\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u65b0\u836f\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u548c\u7a81\u7834\u6027\u6cbb\u7597\u54c1\u79cd\uff0c\u5e76\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\uff0c\u662f\u516c\u53f8\u7684\u9996\u4e2a\u4e0a\u5e02\u54c1\u79cd\u3002\u8be5\u54c1\u79cd\u8fd8\u83b7\u5f97\u4e86\u7f8e\u56fdFDA\u5ba1\u8bc4\u5feb\u901f\u901a\u9053\u3001\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u3001\u4ee5\u53ca\u6b27\u76df\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u3002\u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f8\u5171\u67094\u4e2a\u5728\u7814\u65b0\u836f\u83b7\u5f9712\u9879FDA\u548c1\u9879\u6b27\u76df\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u3002\u516c\u53f8\u5148\u540e\u627f\u62c5\u591a\u9879\u56fd\u5bb6\u79d1\u6280\u91cd\u5927\u4e13\u9879\uff0c\u5176\u4e2d\u201c\u91cd\u5927\u65b0\u836f\u521b\u5236\u201d\u4e13\u98795\u9879\uff0c\u5305\u62ec1\u9879\u201c\u4f01\u4e1a\u521b\u65b0\u836f\u7269\u5b75\u5316\u57fa\u5730\u201d\u53ca4\u9879\u201c\u521b\u65b0\u836f\u7269\u7814\u53d1\u201d\uff0c\u53e6\u5916\u627f\u62c5\u201c\u91cd\u5927\u4f20\u67d3\u75c5\u9632\u6cbb\u201d\u4e13\u98791\u9879\u3002<\/p>\n<p>\u51ed\u501f\u5f3a\u5927\u7684\u7814\u53d1\u80fd\u529b\uff0c\u4e9a\u76db\u533b\u836f\u5df2\u5728\u5168\u7403\u8303\u56f4\u5185\u8fdb\u884c\u77e5\u8bc6\u4ea7\u6743\u5e03\u5c40\uff0c\u5e76\u4e0eUNITY\u3001MD Anderson\u3001\u6885\u5965\u533b\u5b66\u4e2d\u5fc3\u548cDana-Farber\u764c\u75c7\u7814\u7a76\u6240\u3001\u9ed8\u6c99\u4e1c\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f89\u745e\u7b49\u9886\u5148\u7684\u751f\u7269\u6280\u672f\u53ca\u533b\u836f\u516c\u53f8\u3001\u5b66\u672f\u673a\u6784\u8fbe\u6210\u5168\u7403\u5408\u4f5c\u5173\u7cfb\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u4e00\u652f\u5177\u6709\u4e30\u5bcc\u7684\u539f\u521b\u65b0\u836f\u7814\u53d1\u4e0e\u4e34\u5e8a\u5f00\u53d1\u7ecf\u9a8c\u7684\u56fd\u9645\u5316\u4eba\u624d\u56e2\u961f\uff0c\u540c\u65f6\uff0c\u516c\u53f8\u6b63\u5728\u9ad8\u6807\u51c6\u6253\u9020\u540e\u671f\u7684\u5546\u4e1a\u5316\u751f\u4ea7\u53ca\u5e02\u573a\u8425\u9500\u56e2\u961f\u3002\u4e9a\u76db\u533b\u836f\u5c06\u4e0d\u65ad\u63d0\u9ad8\u7814\u53d1\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u8fdb\u516c\u53f8\u4ea7\u54c1\u7ba1\u7ebf\u7684\u4e34\u5e8a\u5f00\u53d1\u8fdb\u5ea6\uff0c\u771f\u6b63\u8df5\u884c\u201c\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u201d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002<\/p>\n<p><b>\u4e9a\u76db\u533b\u836f\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n<p>\u672c\u6587\u6240\u4f5c\u51fa\u7684\u524d\u77bb\u6027\u9648\u8ff0\u4ec5\u4e0e\u672c\u6587\u4f5c\u51fa\u8be5\u9648\u8ff0\u5f53\u65e5\u7684\u4e8b\u4ef6\u6216\u8d44\u6599\u6709\u5173\u3002\u9664\u6cd5\u5f8b\u89c4\u5b9a\u5916\uff0c\u4e8e\u4f5c\u51fa\u524d\u77bb\u6027\u9648\u8ff0\u5f53\u65e5\u4e4b\u540e\uff0c\u65e0\u8bba\u662f\u5426\u51fa\u73b0\u65b0\u8d44\u6599\u3001\u672a\u6765\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u51b5\uff0c\u6211\u4eec\u5e76\u65e0\u8d23\u4efb\u66f4\u65b0\u6216\u516c\u5f00\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9648\u8ff0\u53ca\u9884\u6599\u4e4b\u5916\u7684\u4e8b\u4ef6\u3002\u8bf7\u7ec6\u9605\u672c\u6587\uff0c\u5e76\u7406\u89e3\u6211\u4eec\u7684\u5b9e\u9645\u672a\u6765\u4e1a\u7ee9\u6216\u8868\u73b0\u53ef\u80fd\u4e0e\u9884\u671f\u6709\u91cd\u5927\u5dee\u5f02\u3002\u672c\u6587\u5185\u6240\u6709\u9648\u8ff0\u4e43\u672c\u6587\u7ae0\u520a\u53d1\u65e5\u671f\u4f5c\u51fa\uff0c\u53ef\u80fd\u56e0\u672a\u6765\u53d1\u5c55\u800c\u51fa\u73b0\u53d8\u52a8\u3002<\/p>\n<p><b>\u5173\u4e8e\u4fe1\u8fbe\u751f\u7269<\/b><\/p>\n<p>\u201c\u59cb\u4e8e\u4fe1\uff0c\u8fbe\u4e8e\u884c\u201d\uff0c\u5f00\u53d1\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8d28\u91cf\u751f\u7269\u836f\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u7684\u7406\u60f3\u548c\u76ee\u6807\u3002\u4fe1\u8fbe\u751f\u7269\u6210\u7acb\u4e8e2011\u5e74\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8c22\u75be\u75c5\u7b49\u91cd\u5927\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\u30022018\u5e7410\u670831\u65e5\uff0c\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u5728\u9999\u6e2f\u8054\u5408\u4ea4\u6613\u6240\u6709\u9650\u516c\u53f8\u4e3b\u677f\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a01801\u3002<\/p>\n<p>\u81ea\u6210\u7acb\u4ee5\u6765\uff0c\u516c\u53f8\u51ed\u501f\u521b\u65b0\u6210\u679c\u548c\u56fd\u9645\u5316\u7684\u8fd0\u8425\u6a21\u5f0f\u5728\u4f17\u591a\u751f\u7269\u5236\u836f\u516c\u53f8\u4e2d\u8131\u9896\u800c\u51fa\u3002\u5efa\u7acb\u8d77\u4e86\u4e00\u6761\u5305\u62ec26\u4e2a\u65b0\u836f\u54c1\u79cd\u7684\u4ea7\u54c1\u94fe\uff0c\u8986\u76d6\u80bf\u7624\u3001\u4ee3\u8c22\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u7b49\u591a\u4e2a\u75be\u75c5\u9886\u57df\uff0c\u5176\u4e2d7\u4e2a\u54c1\u79cd\u5165\u9009\u56fd\u5bb6\u201c\u91cd\u5927\u65b0\u836f\u521b\u5236\u201d\u4e13\u9879\u3002\u516c\u53f8\u5df2\u67096\u4e2a\u4ea7\u54c1\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u4f2f\u8212&reg;\uff0c\u82f1\u6587\u5546\u6807\uff1aTYVYT&reg;\uff1b\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u6538\u540c&reg;\uff0c\u82f1\u6587\u5546\u6807\uff1aBYVASDA&reg;\uff1b\u963f\u8fbe\u6728\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u82cf\u7acb\u4fe1&reg;\uff0c\u82f1\u6587\u5546\u6807\uff1aSULINNO&reg;\uff1b\u5229\u59a5\u6614\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u4f2f\u534e&reg;\uff0c\u82f1\u6587\u5546\u6807\uff1aHALPRYZA&reg;\uff1bpemigatinib\u53e3\u670d\u6291\u5236\u5242\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u4f2f\u5766&reg;\uff0c\u82f1\u6587\u5546\u6807\uff1aPEMAZYRE&reg;\uff1b\u5965\u96f7\u5df4\u66ff\u5c3c\u7247\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b&reg;\uff09\u83b7\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u4fe1\u8fea\u5229\u5355\u6297\u5728\u7f8e\u56fd\u7684\u4e0a\u5e02\u7533\u8bf7\u83b7FDA\u53d7\u7406\uff0c5\u4e2a\u54c1\u79cd\u8fdb\u5165III\u671f\u6216\u5173\u952e\u6027\u4e34\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u8fd8\u670915\u4e2a\u4ea7\u54c1\u5df2\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n<p>\u4fe1\u8fbe\u751f\u7269\u5df2\u7ec4\u5efa\u4e86\u4e00\u652f\u5177\u6709\u56fd\u9645\u5148\u8fdb\u6c34\u5e73\u7684\u9ad8\u7aef\u751f\u7269\u836f\u5f00\u53d1\u3001\u4ea7\u4e1a\u5316\u4eba\u624d\u56e2\u961f\uff0c\u5305\u62ec\u4f17\u591a\u6d77\u5f52\u4e13\u5bb6\uff0c\u5e76\u4e0e\u7f8e\u56fd\u793c\u6765\u5236\u836f\u3001Adimab\u3001Incyte\u3001MD Anderson \u764c\u75c7\u4e2d\u5fc3\u548c\u97e9\u56fdHanmi\u7b49\u56fd\u9645\u5408\u4f5c\u65b9\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u3002\u4fe1\u8fbe\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u56fd\u751f\u7269\u5236\u836f\u4ea7\u4e1a\u7684\u53d1\u5c55\u6c34\u5e73\uff0c\u4ee5\u6ee1\u8db3\u767e\u59d3\u7528\u836f\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5bf9\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u613f\u671b\u7684\u8ffd\u6c42\u3002\u8be6\u60c5\u8bf7\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9\uff1awww.innoventbio.com\u6216\u516c\u53f8\u9886\u82f1\u8d26\u53f7<a target=\"_blank\" href=\"http:\/\/www.linkedin.com\/company\/innovent-biologics\/\" rel=\"nofollow noopener\">www.linkedin.com\/company\/innovent-biologics\/<\/a>\u3002<\/p>\n<p><b>\u4fe1\u8fbe\u751f\u7269\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u6240\u53d1\u5e03\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u4f1a\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u8fd9\u4e9b\u8868\u8ff0\u672c\u8d28\u4e0a\u5177\u6709\u76f8\u5f53\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u3002\u5728\u4f7f\u7528\u201c\u9884\u671f\u201d\u3001\u201c\u76f8\u4fe1\u201d\u3001\u201c\u9884\u6d4b\u201d\u3001\u201c\u671f\u671b\u201d\u3001\u201c\u6253\u7b97\u201d\u53ca\u5176\u4ed6\u7c7b\u4f3c\u8bcd\u8bed\u8fdb\u884c\u8868\u8ff0\u65f6\uff0c\u51e1\u4e0e\u672c\u516c\u53f8\u6709\u5173\u7684\uff0c\u76ee\u7684\u5747\u662f\u8981\u6307\u660e\u5176\u5c5e\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u5e76\u65e0\u4e49\u52a1\u4e0d\u65ad\u5730\u66f4\u65b0\u8fd9\u4e9b\u9884\u6d4b\u6027\u9648\u8ff0\u3002<\/p>\n<p>\u8fd9\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u4e8e\u672c\u516c\u53f8\u7ba1\u7406\u5c42\u5728\u505a\u51fa\u8868\u8ff0\u65f6\u5bf9\u672a\u6765\u4e8b\u52a1\u7684\u73b0\u6709\u770b\u6cd5\u3001\u5047\u8bbe\u3001\u671f\u671b\u3001\u4f30\u8ba1\u3001\u9884\u6d4b\u548c\u7406\u89e3\u3002\u8fd9\u4e9b\u8868\u8ff0\u5e76\u975e\u5bf9\u672a\u6765\u53d1\u5c55\u7684\u4fdd\u8bc1\uff0c\u4f1a\u53d7\u5230\u98ce\u9669\u3001\u4e0d\u786e\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u8303\u56f4\uff0c\u96be\u4ee5\u9884\u8ba1\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u4eec\u7684\u4e1a\u52a1\u3001\u7ade\u4e89\u73af\u5883\u3001\u653f\u6cbb\u3001\u7ecf\u6d4e\u3001\u6cd5\u5f8b\u548c\u793e\u4f1a\u60c5\u51b5\u7684\u672a\u6765\u53d8\u5316\u53ca\u53d1\u5c55\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4f1a\u4e0e\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8d44\u6599\u6709\u8f83\u5927\u5dee\u522b\u3002<\/p>\n<p>\u672c\u516c\u53f8\u3001\u672c\u516c\u53f8\u8463\u4e8b\u53ca\u96c7\u5458\u4ee3\u7406\u6982\u4e0d\u627f\u62c5&nbsp;(a) \u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7f51\u7ad9\u6240\u8f7d\u524d\u77bb\u6027\u8868\u8ff0\u7684\u4efb\u4f55\u4e49\u52a1;\u53ca&nbsp;(b) \u82e5\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5b9e\u73b0\u6216\u53d8\u6210\u4e0d\u6b63\u786e\u800c\u5f15\u81f4\u7684\u4efb\u4f55\u8d23\u4efb\u3002<\/p>\n<div>\n<table id=\"convertedTablef52e\" cellspacing=\"0\" cellpadding=\"0\" border=\"1\" class=\"prntblns\">\n<tbody>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[1]&nbsp;National Comprehensive Cancer Network.&nbsp;NCCN Clinical Practice Guidelines in Oncology: Chronic Myelogenous Leukemia, V.2.2008[DB\/OL]. NCCN Web Site. 8-28-2007.[2007-10-25]<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[2]&nbsp;HehlmannR, HochhausA, BaccaraniM, et al.&nbsp;Chronic myeloid leukaemia[J]. Lancet, 2007, 370\uff089584\uff09: 342-350.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[3] \u6162\u6027\u9ad3\u6027\u767d\u8840\u75c5\u4e2d\u56fd\u8bca\u65ad\u4e0e\u6cbb\u7597\u6307\u5357(2020\u5e74\u7248). \u4e2d\u534e\u8840\u6db2\u5b66\u6742\u5fd7. 2020, 41(5): 353-364.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp;<\/p>\n<p>\u76f8\u5173\u94fe\u63a5 :<\/p>\n<blockquote class=\"wp-embedded-content\" data-secret=\"kaQcFOeYiQ\"><p><a href=\"https:\/\/www.ascentagepharma.com\/\">A Leader in the Discovery and Development of Small Molecules that Disrupt Protein-Protein Interactions<\/a><\/p><\/blockquote>\n<p><iframe class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; clip: rect(1px, 1px, 1px, 1px);\" title=\"&#8220;A Leader in the Discovery and Development of Small Molecules that Disrupt Protein-Protein Interactions&#8221; &#8212; Ascentage Pharma\" src=\"https:\/\/www.ascentagepharma.com\/embed\/#?secret=kaQcFOeYiQ\" data-secret=\"kaQcFOeYiQ\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e2d\u56fd\u82cf\u5dde\u548c\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e022021\u5e7412\u67081\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u81f4\u529b\u4e8e\u5728\u80bf\u7624\u3001\u4e59\u809d\u53ca\u4e0e\u8870\u8001\u76f8\u5173\u75be\u75c5\u7b49\u6cbb\u7597\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\u2014\u2014\u4e9a\u76db\u533b\u836f\uff086855.HK\uff09\uff0c\u4e0e\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3001\u4ee3\u8c22\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u7b49\u91cd\u5927\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u5171\u540c\u5ba3\u5e03\uff0c\u4e9a\u76db\u533b\u836f\u5168\u8d44\u5b50\u516c\u53f8\u5e7f\u5dde\u987a\u5065\u751f\u7269\u533b\u836f\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0\u987a\u5065\u533b\u836f\uff09\u7684\u539f\u521b1\u7c7b\u65b0\u836f\u5965\u96f7\u5df4\u66ff\u5c3c\u7247\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b&reg;\uff09\u6b63\u5f0f\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u7684\u4e0a\u5e02\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u4efb\u4f55\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08TKI\uff09\u8010\u836f\uff0c\u5e76\u91c7\u7528\u7ecf\u5145\u5206\u9a8c\u8bc1\u7684\u68c0\u6d4b\u65b9\u6cd5\u8bca\u65ad\u4e3a\u4f34\u6709T315I\u7a81\u53d8\u7684\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\uff08CML\uff09\u6162\u6027\u671f\uff08CP\uff09\u6216\u52a0\u901f\u671f\uff08AP\uff09\u7684\u6210\u5e74\u60a3\u8005\u3002 \u8010\u7acb\u514b&reg;\u662f\u4e9a\u76db\u533b\u836f\u7814\u53d1\u7684\u6f5c\u5728\u540c\u7c7b\u6700\u4f73\uff08Best-in-class\uff09\u65b0\u836f\uff0c\u4e3a\u56fd\u5bb6\u201c\u91cd\u5927\u65b0\u836f\u521b\u5236\u201d\u4e13\u9879\u652f\u6301\u54c1\u79cd\u3002\u8be5\u54c1\u79cd\u5c06\u7531\u4e9a\u76db\u533b\u836f\u4e0e\u4fe1\u8fbe\u751f\u7269\u5171\u540c\u5728\u4e2d\u56fd\u5f00\u5c55\u5546\u4e1a\u5316\u63a8\u5e7f\uff0c\u4ee5\u60e0\u53ca\u66f4\u591a\u60a3\u8005\u53ca\u5176\u5bb6\u5ead\u3002\u4f5c\u4e3a\u4e2d\u56fd\u9996\u4e2a\u4e09\u4ee3BCR-ABL\u9776\u5411\u8010\u836fCML\u6cbb\u7597\u836f\u7269\uff0c\u8010\u7acb\u514b&reg;\u7684\u83b7\u6279\u5c06\u6253\u7834\u4e2d\u56fd\u643aT315I\u7a81\u53d8\u8010\u836f\u60a3\u8005\u7684\u6cbb\u7597\u74f6\u9888\uff0c\u89e3\u51b3\u65e0\u836f\u53ef\u533b\u7684\u56f0\u5883\u3002\u5176\u83b7\u6279\u4e5f\u6807\u5fd7\u7740\u4e9a\u76db\u533b\u836f\u6b63\u5f0f\u6b65\u5165\u5546\u4e1a\u5316\u9636\u6bb5\u3002 \u8010\u7acb\u514b&reg;\u83b7\u6279\u4e3b\u8981\u57fa\u4e8e\u4e24\u9879\u5173\u952e\u6027\u6ce8\u518cII\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff0c\u5206\u522b\u4e3aHQP1351CC201\u7814\u7a76\u3001HQP1351CC202\u7814\u7a76\u3002\u4e34\u5e8a\u6570\u636e\u663e\u793a\u8010\u7acb\u514b&reg;\u5728\u4f34\u6709T315I\u7a81\u53d8\u7684TKI\u8010\u836f\u7684CML-CP\u53caCML-AP\u60a3\u8005\u4e2d\u5747\u5177\u6709\u826f\u597d\u7684\u7597\u6548\u53ca\u8010\u53d7\u6027\uff0c\u4e14\u968f\u7740\u6cbb\u7597\u65f6\u95f4\u7684\u5ef6\u957f\uff0c\u7f13\u89e3\u7387\u548c\u7f13\u89e3\u6df1\u5ea6\u4f1a\u8fdb\u4e00\u6b65\u589e\u52a0\u3002 CML\u662f\u4e00\u79cd\u4e0e\u767d\u7ec6\u80de\u6709\u5173\u7684\u6076\u6027\u80bf\u7624\u3002\u968f\u7740\u9776\u5411BCR-ABL\u7684TKI\u836f\u7269\u4e0a\u5e02\uff0c\u9488\u5bf9CML\u7684\u6cbb\u7597\u65b9\u5f0f\u5f97\u4ee5\u9769\u65b0\uff0c\u4f46\u83b7\u5f97\u6027\u8010\u836f\u4e00\u76f4\u662fCML\u6cbb\u7597\u7684\u4e3b\u8981\u6311\u6218\u3002BCR-ABL\u6fc0\u9176\u533a\u7a81\u53d8\u662f\u83b7\u5f97\u6027\u8010\u836f\u7684\u91cd\u8981\u673a\u5236\u4e4b\u4e00\uff0c\u5176\u4e2dT315I\u7a81\u53d8\u662f\u5e38\u89c1\u7684\u8010\u836f\u7a81\u53d8\u7c7b\u578b\u4e4b\u4e00\uff0c\u5728\u8010\u836fCML\u4e2d\u7684\u53d1\u751f\u7387\u9ad8\u8fbe25%\u5de6\u53f3\u3002\u4f34\u6709T315I\u7a81\u53d8\u7684CML\u60a3\u8005\u5bf9\u76ee\u524d\u6240\u6709\u4e00\u4ee3\u3001\u4e8c\u4ee3BCR-ABL\u6291\u5236\u5242\u5747\u8010\u836f\uff0c\u56e0\u6b64\u5728\u8fc7\u53bb\u4e00\u76f4\u9762\u4e34\u65e0\u836f\u53ef\u533b\u7684\u7a98\u5883\u3002 \u8010\u7acb\u514b&reg;\u4e2d\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u4e3b\u8981\u7814\u7a76\u8005\u3001\u5317\u4eac\u5927\u5b66\u8840\u6db2\u75c5\u7814\u7a76\u6240\u6240\u957f\u3001\u5317\u4eac\u5927\u5b66\u4eba\u6c11\u533b\u9662\u8840\u6db2\u79d1\u4e3b\u4efb\u9ec4\u6653\u519b\u6559\u6388\u8868\u793a\uff1a\u201c\u8fc7\u5f80\u4e34\u5e8a\u7814\u7a76\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u6570\u636e\u4e0d\u65ad\u5411\u6211\u4eec\u663e\u793a\uff0c\u8010\u7acb\u514b&reg;\u5728\u8010\u836f\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\u8fd9\u4e2a\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u9886\u57df\u6f5c\u529b\u5de8\u5927\uff0c\u6781\u6709\u5e0c\u671b\u6210\u4e3a\u8be5\u9886\u57df\u6cbb\u7597\u7684\u2018Best-in-Class\u2019\u836f\u7269\u3002\u8fd1\u51e0\u5e74\u6765\uff0c\u8fd9\u4e00\u836f\u7269\u7684\u4e34\u5e8a\u8fdb\u5c55\u4e5f\u4e0d\u65ad\u53d7\u5230\u5168\u7403\u8840\u6db2\u5b66\u754c\u7684\u5173\u6ce8\u3002\u5f88\u9ad8\u5174\u770b\u5230\u8010\u7acb\u514b&reg;\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\u3002\u8fd9\u4e0d\u4ec5\u610f\u5473\u7740\u4e2d\u56fd\u7684CML\u6cbb\u7597\u6253\u7834\u4e86\u539f\u6709\u7684\u8010\u836f\u56f0\u5883\u3001\u8fce\u6765\u4e86\u5168\u65b0\u7684\u91cc\u7a0b\u7891\uff1b\u66f4\u610f\u5473\u7740\u4e2d\u56fd\u5728\u8840\u6db2\u80bf\u7624\u9886\u57df\u7684\u4e34\u5e8a\u5b9e\u529b\u6b63\u9010\u6e10\u8d70\u5411\u4e16\u754c\u524d\u6cbf\u3002\u201d \u8010\u7acb\u514b&reg;\u4e2d\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u4e3b\u8981\u7814\u7a76\u8005\u3001\u5317\u4eac\u5927\u5b66\u4eba\u6c11\u533b\u9662\u8840\u6db2\u79d1\u526f\u4e3b\u4efb\u6c5f\u5029\u6559\u6388\u8868\u793a\uff1a\u201cCML-CP\u53caCML-AP\u60a3\u8005\u4e00\u65e6\u51fa\u73b0T315I\u7a81\u53d8\uff0c\u6240\u6709\u7684\u4e00\u4ee3\u6216\u4e8c\u4ee3TKI\u5bf9\u8fd9\u4e9b\u60a3\u8005\u90fd\u65e0\u6548\u3002\u5728\u4eca\u5929\u4e4b\u524d\uff0c\u8fd9\u90fd\u662f\u4e00\u4e2a\u4e34\u5e8a\u9700\u6c42\u9ad8\u5ea6\u672a\u88ab\u6ee1\u8db3\u7684\u9886\u57df\u3002\u800c\u8010\u7acb\u514b&reg;\u7684\u83b7\u6279\u5c06\u89e3\u5f00\u8fd9\u4e00\u65e0\u836f\u53ef\u533b\u7684\u56f0\u5c40\uff0c\u5bf9\u4e34\u5e8a\u533b\u751f\u548c\u60a3\u8005\u7684\u610f\u4e49\u5de8\u5927\u3002\u76f8\u4fe1\u968f\u7740\u8fd9\u4e00\u836f\u7269\u7684\u4e0a\u5e02\uff0c\u66f4\u591aCML\u60a3\u8005\u80fd\u591f\u5ef6\u7eed\u751f\u547d\u7684\u7cbe\u5f69\u3002\u201d \u4e9a\u76db\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98\uff0c\u987a\u5065\u533b\u836f\u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u201c\u611f\u8c22\u5404\u7ea7\u836f\u76d1\u90e8\u95e8\u548c\u76f8\u5173\u673a\u6784\u5bf9\u8010\u836fCML\u60a3\u8005\u6cbb\u7597\u9700\u6c42\u7684\u9ad8\u5ea6\u5173\u6ce8\uff0c\u4ee5\u53ca\u5bf9\u4e2d\u56fd\u672c\u571f\u521b\u65b0\u836f\u53d1\u5c55\u7684\u5927\u529b\u652f\u6301\uff01\u611f\u8c22\u4f17\u591a\u4e34\u5e8a\u4e13\u5bb6\u4e0e\u60a3\u8005\u7684\u503e\u60c5\u4ed8\u51fa\u4e0e\u5145\u5206\u4fe1\u4efb\uff01\u611f\u8c22\u6211\u4eec\u56e2\u961f\u6210\u5458\u7684\u575a\u5b88\uff0c\u7279\u522b\u662f\u5728\u75ab\u60c5\u4e0b\u80fd\u514b\u670d\u5404\u79cd\u524d\u6240\u672a\u6709\u7684\u6311\u6218\u4e0e\u56f0\u96be\uff01\u6b64\u6b21\u8010\u7acb\u514b&reg;\u7684\u83b7\u6279\u4e0a\u5e02\u610f\u4e49\u975e\u51e1\uff0c\u4f5c\u4e3a\u4e2d\u56fd\u9996\u4e2a\u3001\u5168\u7403\u7b2c\u4e8c\u4e2a\u83b7\u6279\u4e0a\u5e02\u7684\u4e09\u4ee3BCR-ABL\u6291\u5236\u5242\uff0c\u5b83\u4e0d\u4ec5\u80fd\u6539\u53d8\u4e2d\u56fd\u643aT315I\u7a81\u53d8\u8010\u836f\u60a3\u8005\u65e0\u836f\u53ef\u533b\u7684\u73b0\u72b6\uff0c\u4e5f\u6709\u671b\u586b\u8865\u5168\u7403CML\u6cbb\u7597\u672a\u88ab\u6ee1\u8db3\u7684\u4e34\u5e8a\u7a7a\u767d\u3002\u201d \u4e9a\u76db\u533b\u836f\u8463\u4e8b\u957f\u3001CEO\u6768\u5927\u4fca\u535a\u58eb\u8868\u793a\uff1a\u201c\u4f5c\u4e3a\u516c\u53f8\u7684\u7b2c\u4e00\u4e2a\u5546\u4e1a\u5316\u4ea7\u54c1\uff0c\u8010\u7acb\u514b&reg;\u7684\u83b7\u6279\u65e0\u7591\u662f\u91cd\u5927\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff0c\u610f\u5473\u7740\u4e9a\u76db\u533b\u836f\u4ece\u7814\u53d1\u578b\u516c\u53f8\u5230\u6709\u4ea7\u54c1\u4e0a\u5e02\u7684\u516c\u53f8\u7684\u6210\u529f\u8de8\u8d8a\uff0c\u4e3a\u6211\u4eec\u5e26\u6765\u4e86\u6781\u5927\u7684\u4fe1\u5fc3\u3002\u6211\u4eec\u5c06\u4e0e\u4fe1\u8fbe\u751f\u7269\u901a\u529b\u5408\u4f5c\uff0c\u5168\u9762\u63d0\u901f\u5546\u4e1a\u5316\u5e03\u5c40\u3002\u6b64\u5916\u3002\u6211\u4eec\u6b63\u79ef\u6781\u63a8\u8fdb\u4e0e\u57fa\u56e0\u68c0\u6d4b\u516c\u53f8\u3001\u5546\u4e1a\u4fdd\u9669\u516c\u53f8\u3001\u4e92\u8054\u7f51\u533b\u836f\u7b49\u591a\u65b9\u7684\u5408\u4f5c\uff0c\u5e0c\u671b\u5c3d\u5feb\u5c06\u8fd9\u6b3e\u5168\u7403\u9886\u5148\u3001\u4e2d\u56fd\u539f\u521b\u7684\u4ea7\u54c1\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002\u6211\u4eec\u5c06\u59cb\u7ec8\u575a\u5b88\u5168\u7403\u521b\u65b0\u5b9a\u4f4d\uff0c\u8df5\u884c\u2018\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u2019\u7684\u4f7f\u547d\u2019\u3002\u672a\u6765\uff0c\u4e9a\u76db\u533b\u836f\u5c06\u8fdb\u4e00\u6b65\u8fdb\u884c\u8be5\u54c1\u79cd\u65b0\u9002\u5e94\u75c7\u7684\u62d3\u5c55\u4ee5\u53ca\u6d77\u5916\u4e34\u5e8a\u7684\u63a8\u8fdb\uff0c\u5e76\u7ee7\u7eed\u52a0\u901f\u516c\u53f8\u5176\u4ed6\u5728\u7814\u54c1\u79cd\u7684\u5168\u7403\u5f00\u53d1\uff0c\u771f\u6b63\u5b9e\u73b0\u2018\u4ece\u4e2d\u56fd\u8d70\u5411\u4e16\u754c\u2019\u3002\u201d \u4fe1\u8fbe\u751f\u7269\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u957f\u517cCEO\u4fde\u5fb7\u8d85\u535a\u58eb\u8868\u793a\uff1a\u201c\u6211\u4eec\u5f88\u9ad8\u5174\u8010\u7acb\u514b&reg;\u5728\u4e2d\u56fd\u6210\u529f\u83b7\u6279\uff0c\u4e3a\u4fe1\u8fbe\u751f\u7269\u5728\u8840\u6db2\u7624\u9886\u57df\u7684\u6df1\u539a\u5e03\u5c40\u518d\u6dfb\u4e00\u6b3e\u65b0\u4e00\u4ee3\u6297\u80bf\u7624\u4ea7\u54c1\u3002\u4fe1\u8fbe\u751f\u7269\u5728\u6297\u80bf\u7624\u9886\u57df\u62e5\u6709\u96c4\u539a\u768420\u6b3e\u4e34\u5e8a\u9636\u6bb5\u7ba1\u7ebf\u3001\u4e1a\u5185\u9886\u5148\u7684\u4e34\u5e8a\u5f00\u53d1\u548c\u6ce8\u518c\u56e2\u961f\u3001\u5e7f\u9614\u7684\u5546\u4e1a\u6e20\u9053\u8986\u76d6\u53ca\u8fd13000\u4eba\u7684\u5546\u4e1a\u5316\u56e2\u961f\u3002\u6211\u4eec\u671f\u5f85\u4e0e\u4e9a\u76db\u533b\u836f\u5728\u8be5\u4ea7\u54c1\u7684\u4e2d\u56fd\u5e02\u573a\u8986\u76d6\u548c\u5546\u4e1a\u5316\u63a8\u5e7f\u4e0a\u7684\u7d27\u5bc6\u5408\u4f5c\uff0c\u5c3d\u5feb\u6ee1\u8db3TKI\u8010\u836fT315I\u7a81\u53d8\u7684CML\u60a3\u8005\u7684\u4e9f\u5f85\u6cbb\u7597\u7684\u4e34\u5e8a\u9700\u6c42\u3002\u201d &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;END&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212; \u5173\u4e8e\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5 \u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\uff08Chronic Myeloid Leukemia, CML\uff09\uff0c\u662f\u9aa8\u9ad3\u9020\u8840\u5e72\u7ec6\u80de\u514b\u9686\u6027\u589e\u6b96\u5f62\u6210\u7684\u6076\u6027\u80bf\u7624\uff0c\u4e5f\u88ab\u79f0\u4e3a\u6162\u6027\u7c92\u7ec6\u80de\u767d\u8840\u75c5\uff0c\u662f\u6162\u6027\u767d\u8840\u75c5\u4e2d\u6700\u5e38\u89c1\u7684\u4e00\u79cd\u7c7b\u578b\uff0c\u5360\u6210\u4eba\u767d\u8840\u75c5\u768415%[1]-[2]\u3002\u4e2d\u56fdCML\u60a3\u8005\u53d1\u75c5\u8f83\u897f\u65b9\u66f4\u4e3a\u5e74\u8f7b\u5316\uff0c\u6d41\u884c\u75c5\u5b66\u8c03\u67e5\u663e\u793a\uff0c\u4e2d\u56fdCML\u7684\u4e2d\u4f4d\u53d1\u75c5\u5e74\u9f84\u4e3a45~50\u5c81\uff0c\u897f\u65b9\u56fd\u5bb6CML\u7684\u4e2d\u4f4d\u53d1\u75c5\u5e74\u9f84\u4e3a67\u5c81[3]\u3002 \u968f\u7740\u9776\u5411BCR-ABL\u7684TKI\u836f\u7269\u4e0a\u5e02\uff0c\u9488\u5bf9CML\u7684\u6cbb\u7597\u65b9\u5f0f\u5f97\u4ee5\u9769\u65b0\uff0c\u4f46\u83b7\u5f97\u6027\u8010\u836f\u4e00\u76f4\u662fCML\u6cbb\u7597\u7684\u4e3b\u8981\u6311\u6218\u3002BCR-ABL\u6fc0\u9176\u533a\u7a81\u53d8\u662f\u83b7\u5f97\u6027\u8010\u836f\u7684\u91cd\u8981\u673a\u5236\u4e4b\u4e00\uff0c\u5176\u4e2dT315I\u7a81\u53d8\u662f\u5e38\u89c1\u7684\u8010\u836f\u7a81\u53d8\u7c7b\u578b\u4e4b\u4e00\uff0c\u5728\u8010\u836fCML\u4e2d\u7684\u53d1\u751f\u7387\u9ad8\u8fbe25%\u5de6\u53f3\u3002\u4f34\u6709T315I\u7a81\u53d8\u7684CML\u60a3\u8005\u5bf9\u76ee\u524d\u6240\u6709\u4e00\u4ee3\u3001\u4e8c\u4ee3BCR-ABL\u6291\u5236\u5242\u5747\u8010\u836f\uff0c\u5728\u8fc7\u53bb\u4e00\u76f4\u662fCML\u60a3\u8005\u7fa4\u4f53\u957f\u671f\u751f\u5b58\u7684\u963b\u788d\u3002 \u5173\u4e8e\u8010\u7acb\u514b&reg; \u8010\u7acb\u514b&reg;\u662f\u4e9a\u76db\u533b\u836f\u539f\u521b1\u7c7b\u65b0\u836f\uff0c\u4e3a\u53e3\u670d\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5242\uff0c\u662f\u4e2d\u56fd\u9996\u4e2a\u83b7\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u9776\u5411\u8010\u836fCML\u6cbb\u7597\u836f\u7269\uff0c\u5bf9BCR-ABL\u4ee5\u53ca\u5305\u62ecT315I\u7a81\u53d8\u5728\u5185\u7684\u591a\u79cdBCR-ABL\u7a81\u53d8\u4f53\u6709\u7a81\u51fa\u6548\u679c\uff0c\u83b7\u56fd\u5bb6\u201c\u91cd\u5927\u65b0\u836f\u521b\u5236\u201c\u4e13\u9879\u652f\u6301\u3002 2020\u5e7410\u6708\uff0c\u8010\u7acb\u514b&reg;\u88abNMPA\u65b0\u836f\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\uff0c\u7528\u4e8e\u6cbb\u7597TKI\u8010\u836f\u540e\u5e76\u4f34\u6709T315I\u7a81\u53d8\u7684CML\u6162\u6027\u671f\u6216\u52a0\u901f\u671f\u7684\u6210\u5e74\u60a3\u8005\uff1b2021\u5e743\u6708\uff0c\u8be5\u54c1\u79cd\u88abCDE\u7eb3\u5165\u7a81\u7834\u6027\u6cbb\u7597\u54c1\u79cd\u3002\u800c\u5728\u6d77\u5916\uff0c\u8be5\u54c1\u79cd\u4e8e2019\u5e747\u6708\u83b7FDA\u4e34\u5e8a\u8bd5\u9a8c\u8bb8\u53ef\uff0c\u76f4\u63a5\u8fdb\u5165Ib\u671f\u4e34\u5e8a\u7814\u7a76\uff1b2020\u5e745\u6708\u63a5\u8fde\u83b7\u5f97\u7f8e\u56fdFDA\u6388\u4e88\u7684\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u548c\u5ba1\u8bc4\u5feb\u901f\u901a\u9053\u8d44\u683c\uff1b2021\u5e7411\u6708\u83b7\u6b27\u76df\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\uff1b\u6b64\u5916\uff0c\u8be5\u54c1\u79cd\u7684\u4e34\u5e8a\u8bd5\u9a8c\u8fdb\u5c55\u81ea2018\u5e74\u5f00\u59cb\uff0c\u8fde\u7eed\u56db\u5e74\u5165\u9009\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08ASH\uff09\u5e74\u4f1a\u53e3\u5934\u62a5\u544a\uff0c\u5e76\u8363\u83b72019 ASH\u5e74\u4f1a\u201c\u6700\u4f73\u7814\u7a76\u201d\u7684\u63d0\u540d\u3002 2021\u5e747\u6708\uff0c\u4e9a\u76db\u533b\u836f\u4e0e\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\uff081801.HK\uff09\u8fbe\u6210\u5728\u4e2d\u56fd\u5e02\u573a\u5c31\u8010\u7acb\u514b&reg;\u5171\u540c\u5f00\u53d1\u548c\u5171\u540c\u5546\u4e1a\u5316\u63a8\u5e7f\u7684\u6218\u7565\u5408\u4f5c\u3002 *\u6ce8&nbsp;\u8010\u7acb\u514b&reg;\u4e3a\u4e9a\u76db\u533b\u836f\u7684\u6ce8\u518c\u5546\u6807 \u5173\u4e8e\u4e24\u9879\u5173\u952e\u6027\u6ce8\u518cII\u671f\u4e34\u5e8a\u7814\u7a76 \u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\u2014\u2014\u6162\u6027\u671f\u60a3\u8005&nbsp;HQP1351CC201\u7814\u7a76 HQP1351CC201\u662f\u4e00\u9879\u5f00\u653e\u3001\u591a\u4e2d\u5fc3\u3001\u5355\u81c2\u8bbe\u8ba1\u7684II \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u5bf9\u5965\u96f7\u5df4\u66ff\u5c3c\u7247\u6cbb\u7597\u4efb\u4f55\u9776\u5411BCR-ABL1 \u7684TKI\u6cbb\u7597\u540e\u51fa\u73b0T315I \u7a81\u53d8\u7684CML-CP\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u8fdb\u884c\u8bc4\u4ef7\u3002\u8be5\u9879\u8bd5\u9a8c\u7684\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u4e3a\u4e3b\u8981\u7ec6\u80de\u9057\u4f20\u5b66\u7f13\u89e3\uff08MCyR\uff09\u3002 \u622a\u81f32020\u5e748\u670825\u65e5\uff0c\u5965\u96f7\u5df4\u66ff\u5c3c\u5728CML-CP\u60a3\u8005\u4e2d\u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f413.0\u4e2a\u6708\uff08\u8303\u56f4\uff1a7.2- 16.3\uff09\u300231\u4f8b\u8840\u6db2\u5b66\u53cd\u5e94\u53ef\u8bc4\u4f30\u53d7\u8bd5\u8005\u4e2d\uff0c31\u4f8b\uff08100%\uff09\u83b7\u5f97\u5b8c\u5168\u8840\u6db2\u5b66\u53cd\u5e94\uff08CHR\uff09\uff1b41\u4f8b\u7ec6\u80de\u9057\u4f20\u5b66\u53ef\u8bc4\u4f30\u53d7\u8bd5\u8005\u4e2d\uff0c31\u4f8b\uff0875.6 %\uff09\u83b7\u5f97\u4e3b\u8981\u7ec6\u80de\u9057\u4f20\u5b66\u53cd\u5e94\uff08MCyR\uff09\uff0c\u5305\u62ec28\u4f8b\uff0868.3%\uff09\u5b8c\u5168\u7ec6\u80de\u9057\u4f20\u5b66\u53cd\u5e94\uff08CCyR\uff09\u548c3\u4f8b\uff087.3%\uff09\u90e8\u5206\u7ec6\u80de\u9057\u4f20\u5b66\u53cd\u5e94\uff08PCyR\uff09\uff1b41\u4f8b\u5206\u5b50\u5b66\u53cd\u5e94\u53ef\u8bc4\u4f30\u7684\u53d7\u8bd5\u8005\u4e2d\uff0c23\u4f8b\uff0856.1%\uff09\u83b7\u5f97\u4e3b\u8981\u5206\u5b50\u5b66\u53cd\u5e94\uff08MMR\uff09\u300212\u4e2a\u6708\u65e0\u8fdb\u5c55\u751f\u5b58\uff08PFS\uff09\u7387\u4e3a85.7%\uff0895% CI\uff1a[63.6% &#8211; 94.9%]\uff09\uff0c\u603b\u4f53\u751f\u5b58\uff08OS\uff09\u7387\u4e3a100%\uff0895% CI\uff1a[100.0% -100.0%]\uff09\u3002 \u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\u2014\u2014\u52a0\u901f\u671f\u60a3\u8005HQP1351CC202 \u7814\u7a76 HQP1351CC202\u662f\u5728\u4e00\u9879\u5f00\u653e\u3001\u591a\u4e2d\u5fc3\u3001\u5355\u81c2\u8bbe\u8ba1\u7684II \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u5bf9\u5965\u96f7\u5df4\u66ff\u5c3c\u7247\u6cbb\u7597\u4efb\u4f55\u9776\u5411BCR-ABL1\u7684TKI\u6cbb\u7597\u540e\u51fa\u73b0\u9488\u5bf9TKI\u8010\u836f\u4f34\u6709T315I\u7a81\u53d8\u7684CML-AP\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u8fdb\u884c\u8bc4\u4ef7\u3002\u8be5\u9879\u8bd5\u9a8c\u7684\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u4e3a\u4e3b\u8981\u8840\u6db2\u5b66\u53cd\u5e94\u7387\uff08MaHR\uff09\u3002 \u622a\u81f32020\u5e747\u670827\u65e5\uff0c\u5965\u96f7\u5df4\u66ff\u5c3c\u5728CML-AP\u60a3\u8005\u4e2d\u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f414.3\u4e2a\u6708\uff08\u8303\u56f4\uff1a6.6-15.2\uff09\u300217\u4f8b\u53ef\u8bc4\u4f30\u7684\u53d7\u8bd5\u8005\u4e2d\uff0c12\u4f8b\uff0870.6%\uff09\u83b7\u5f97\u4e3b\u8981\u8840\u6db2\u5b66\u53cd\u5e94\uff08MaHR\uff09\uff0c\u5305\u62ec11\u4f8b\uff0864.7%\uff09\u5b8c\u5168\u8840\u6db2\u5b66\u53cd\u5e94\uff08CHR\uff09\u548c1\u4f8b\uff085.9%\uff09\u65e0\u767d\u8840\u75c5\u8bc1\u636e\uff08NEL\uff09\u300217\u4f8b\u53ef\u8bc4\u4f30\u53d7\u8bd5\u8005\u4e2d\uff0c8\u4f8b\uff0847.1%\uff09\u83b7\u5f97\u4e3b\u8981\u7ec6\u80de\u9057\u4f20\u5b66\u53cd\u5e94\uff08MCyR\uff09\uff0c\u5305\u62ec8\u4f8b\uff0847.1%\uff09\u5b8c\u5168\u7ec6\u80de\u9057\u4f20\u5b66\u53cd\u5e94\uff08CCyR\uff09\u300217\u4f8b\u53ef\u8bc4\u4f30\u7684\u53d7\u8bd5\u8005\u4e2d\uff0c7\u4f8b\uff0841.2%\uff09\u83b7\u5f97\u4e3b\u8981\u5206\u5b50\u5b66\u53cd\u5e94\uff08MMR\uff09\u300212\u4e2a\u6708\u7684PFS\u7387\u4e3a73.3%\uff0895% CI\uff1a[43.3% &#8211; 89.1%]\uff09\u300212\u4e2a\u6708OS\u4e3a88.2%\uff0895% CI\uff1a[60.6% -96.9%]\uff09\u3002 \u5173\u4e8e\u4e9a\u76db\u533b\u836f \u4e9a\u76db\u533b\u836f\u662f\u4e00\u5bb6\u7acb\u8db3\u4e2d\u56fd\u3001\u9762\u5411\u5168\u7403\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\uff0c\u81f4\u529b\u4e8e\u5728\u80bf\u7624\u3001\u4e59\u809d\u53ca\u4e0e\u8870\u8001\u76f8\u5173\u7684\u75be\u75c5\u7b49\u6cbb\u7597\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u30022019\u5e7410\u670828\u65e5\uff0c\u4e9a\u76db\u533b\u836f\u5728\u9999\u6e2f\u8054\u4ea4\u6240\u4e3b\u677f\u6302\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a6855.HK\u3002 \u4e9a\u76db\u533b\u836f\u62e5\u6709\u81ea\u4e3b\u6784\u5efa\u7684\u86cb\u767d-\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u9776\u5411\u836f\u7269\u8bbe\u8ba1\u5e73\u53f0\uff0c\u5904\u4e8e\u7ec6\u80de\u51cb\u4ea1\u901a\u8def\u65b0\u836f\u7814\u53d1\u7684\u5168\u7403\u6700\u524d\u6cbf\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u62e5\u67098\u4e2a\u5df2\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u76841\u7c7b\u5c0f\u5206\u5b50\u65b0\u836f\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u3001IAP \u6216&nbsp;MDM2-p53 \u7b49\u7ec6\u80de\u51cb\u4ea1\u8def\u5f84\u5173\u952e\u86cb\u767d\u7684\u6291\u5236\u5242\uff1b\u65b0\u4e00\u4ee3\u9488\u5bf9\u764c\u75c7\u6cbb\u7597\u4e2d\u51fa\u73b0\u7684\u6fc0\u9176\u7a81\u53d8\u4f53\u7684\u6291\u5236\u5242\u7b49\uff0c\u4e3a\u5168\u7403\u552f\u4e00\u5728\u7ec6\u80de\u51cb\u4ea1\u8def\u5f84\u5173\u952e\u86cb\u767d\u9886\u57df\u5747\u6709\u4e34\u5e8a\u5f00\u53d1\u54c1\u79cd\u7684\u521b\u65b0\u516c\u53f8\u3002\u76ee\u524d\u516c\u53f8\u6b63\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u53ca\u6b27\u6d32\u5f00\u5c5540\u591a\u9879I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u7528\u4e8e\u6cbb\u7597\u8010\u836f\u6027\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\u7684\u6838\u5fc3\u54c1\u79cd\u5965\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b&reg;\uff09\u66fe\u83b7\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u65b0\u836f\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u548c\u7a81\u7834\u6027\u6cbb\u7597\u54c1\u79cd\uff0c\u5e76\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\uff0c\u662f\u516c\u53f8\u7684\u9996\u4e2a\u4e0a\u5e02\u54c1\u79cd\u3002\u8be5\u54c1\u79cd\u8fd8\u83b7\u5f97\u4e86\u7f8e\u56fdFDA\u5ba1\u8bc4\u5feb\u901f\u901a\u9053\u3001\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u3001\u4ee5\u53ca\u6b27\u76df\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u3002\u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f8\u5171\u67094\u4e2a\u5728\u7814\u65b0\u836f\u83b7\u5f9712\u9879FDA\u548c1\u9879\u6b27\u76df\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u3002\u516c\u53f8\u5148\u540e\u627f\u62c5\u591a\u9879\u56fd\u5bb6\u79d1\u6280\u91cd\u5927\u4e13\u9879\uff0c\u5176\u4e2d\u201c\u91cd\u5927\u65b0\u836f\u521b\u5236\u201d\u4e13\u98795\u9879\uff0c\u5305\u62ec1\u9879\u201c\u4f01\u4e1a\u521b\u65b0\u836f\u7269\u5b75\u5316\u57fa\u5730\u201d\u53ca4\u9879\u201c\u521b\u65b0\u836f\u7269\u7814\u53d1\u201d\uff0c\u53e6\u5916\u627f\u62c5\u201c\u91cd\u5927\u4f20\u67d3\u75c5\u9632\u6cbb\u201d\u4e13\u98791\u9879\u3002 \u51ed\u501f\u5f3a\u5927\u7684\u7814\u53d1\u80fd\u529b\uff0c\u4e9a\u76db\u533b\u836f\u5df2\u5728\u5168\u7403\u8303\u56f4\u5185\u8fdb\u884c\u77e5\u8bc6\u4ea7\u6743\u5e03\u5c40\uff0c\u5e76\u4e0eUNITY\u3001MD&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2021120107000054730\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":8278,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-54730","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/54730","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=54730"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/54730\/revisions"}],"predecessor-version":[{"id":54731,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/54730\/revisions\/54731"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/8278"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=54730"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=54730"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=54730"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}