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id=\"spanHghlt5ff6\">\u4e00\u7bc7\u520a\u767b\u5728Nature Metabolism\u4e0a\u7684\u6587\u7ae0\u300aGenomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals\u300b<\/span>\uff0c\u67d0\u79cd\u7a0b\u5ea6\u5370\u8bc1\u4e86\u5e8f\u796f\u8fbe\u65b9\u5411\u7684\u524d\u666f\u3002\u7814\u7a76\u4eba\u5458\u5c0690\u79cd\u5fc3\u8840\u7ba1\u86cb\u767d\u7684\u86cb\u767d\u8d28\u6570\u91cf\u6027\u72b6\u4f4d\u70b9\uff08pQTL\uff09\u6620\u5c04\u548c\u590d\u5236\u57283\u4e07\u4e2a\u4e2a\u4f53\u4e2d\uff0c\u6700\u7ec8\u5f97\u523085\u79cd\u86cb\u767d\u7684451\u4e2apQTL\u3002\u8be5\u7814\u7a76\u786e\u5b9a\u4e8611\u79cd\u6b64\u524d\u672a\u88ab\u9776\u5411\u7684\u4e0e\u76f8\u5173\u75be\u75c5\u6709\u56e0\u679c\u5173\u7cfb\u7684\u86cb\u767d\uff0c\u9a8c\u8bc1\u4e86\u86cb\u767d\u8d28\u7ec4\u9057\u4f20\u5b66\u5927\u89c4\u6a21\u56fe\u8c31\u7684\u5b9e\u7528\u6027\uff0c\u5e76\u4e3a\u672a\u6765\u4eba\u7c7b\u5065\u5eb7\u4e2d\u5faa\u73af\u86cb\u767d\u8d28\u7684\u7cbe\u786e\u7814\u7a76\u63d0\u4f9b\u8d44\u6e90\u3002<\/p>\n<p>\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5e8f\u796f\u8fbe\u6b64\u6b21\u5165\u5b75\u6240\u8ba1\u5212\u542f\u52a8\u7684\u9879\u76ee\u5c31\u8ddf\u86cb\u767d\u7ec4\u5b66\u76f8\u5173\u300211\u670817\u65e5\uff0c\u674e\u6e90\u535a\u58eb\u5728\u7ea2\u6749\u4e2d\u56fd\u667a\u80fd\u533b\u7597\u57fa\u56e0\u7ec4\u5b66\u5b75\u5316\u5668\uff08\u56e0\u7f8e\u7eb3\u6280\u672f\u9a71\u52a8\uff09\u542f\u7528\u4eea\u5f0f\u4e0a\u516c\u5e03\u4e86\u8fd9\u4e00\u5343\u4eba\u89c4\u6a21\u961f\u5217\u9879\u76ee\u3002<\/p>\n<div 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2020\u5e7410\u6708\uff0c\u4e00\u7bc7\u520a\u767b\u5728Nature Metabolism\u4e0a\u7684\u6587\u7ae0\u300aGenomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals\u300b\uff0c\u67d0\u79cd\u7a0b\u5ea6\u5370\u8bc1\u4e86\u5e8f\u796f\u8fbe\u65b9\u5411\u7684\u524d\u666f\u3002\u7814\u7a76\u4eba\u5458\u5c0690\u79cd\u5fc3\u8840\u7ba1\u86cb\u767d\u7684\u86cb\u767d\u8d28\u6570\u91cf\u6027\u72b6\u4f4d\u70b9\uff08pQTL\uff09\u6620\u5c04\u548c\u590d\u5236\u57283\u4e07\u4e2a\u4e2a\u4f53\u4e2d\uff0c\u6700\u7ec8\u5f97\u523085\u79cd\u86cb\u767d\u7684451\u4e2apQTL\u3002\u8be5\u7814\u7a76\u786e\u5b9a\u4e8611\u79cd\u6b64\u524d\u672a\u88ab\u9776\u5411\u7684\u4e0e\u76f8\u5173\u75be\u75c5\u6709\u56e0\u679c\u5173\u7cfb\u7684\u86cb\u767d\uff0c\u9a8c\u8bc1\u4e86\u86cb\u767d\u8d28\u7ec4\u9057\u4f20\u5b66\u5927\u89c4\u6a21\u56fe\u8c31\u7684\u5b9e\u7528\u6027\uff0c\u5e76\u4e3a\u672a\u6765\u4eba\u7c7b\u5065\u5eb7\u4e2d\u5faa\u73af\u86cb\u767d\u8d28\u7684\u7cbe\u786e\u7814\u7a76\u63d0\u4f9b\u8d44\u6e90\u3002 \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5e8f\u796f\u8fbe\u6b64\u6b21\u5165\u5b75\u6240\u8ba1\u5212\u542f\u52a8\u7684\u9879\u76ee\u5c31\u8ddf\u86cb\u767d\u7ec4\u5b66\u76f8\u5173\u300211\u670817\u65e5\uff0c\u674e\u6e90\u535a\u58eb\u5728\u7ea2\u6749\u4e2d\u56fd\u667a\u80fd\u533b\u7597\u57fa\u56e0\u7ec4\u5b66\u5b75\u5316\u5668\uff08\u56e0\u7f8e\u7eb3\u6280\u672f\u9a71\u52a8\uff09\u542f\u7528\u4eea\u5f0f\u4e0a\u516c\u5e03\u4e86\u8fd9\u4e00\u5343\u4eba\u89c4\u6a21\u961f\u5217\u9879\u76ee\u3002 \u5e8f\u796f\u8fbe\u603b\u7ecf\u7406\u674e\u6e90 \u201c\u57fa\u4e8e\u8fd9\u4e2a\u9879\u76ee\u6253\u9020\u51fa\u7684\u6a21\u5f0f\uff0c\u6211\u4eec\u5e0c\u671b\u80fd\u63d0\u4f9b\u4e00\u4e2a\u9ad8\u54c1\u8d28\u6570\u636e\u5e73\u53f0\uff0c\u94fe\u63a5\u4ea7\u4e1a\u94fe\u4e0a\u4e0b\u6e38\uff0c\u63a8\u52a8\u521b\u65b0\u836f\u7269\u7814\u53d1\u3002\u201d\u674e\u6e90\u535a\u58eb\u6982\u62ec\u8bf4\uff0c\u201c\uff08\u5e8f\u796f\u8fbe\uff09\u5c31\u50cf\u6865\u6881\u7684\u4f5c\u7528\u4e00\u6837\u3002\u201d \u5728\u6a21\u5f0f\u521b\u65b0\u4e4b\u5916\uff0c\u5e8f\u796f\u8fbe\u80fd\u5f97\u5230\u7ea2\u6749\u4e2d\u56fd\u548cIllumina\u7684\u80af\u5b9a\uff0c\u4e5f\u79bb\u4e0d\u5f00\u9ad8\u6548\u7684\u8fd0\u8425\u7ba1\u7406\u56e2\u961f\u3002 \u674e\u6e90\u535a\u58eb\u8868\u793a\uff0c\u5e8f\u796f\u8fbe\u867d\u7136\u6210\u7acb\u4ec5\u4e00\u5e74\uff0c\u6838\u5fc3\u56e2\u961f\u5374\u7531\u751f\u7269\u533b\u836f\u9886\u57df\u8d44\u6df1\u4ece\u4e1a\u4eba\u5458\u548c\u6765\u81ea\u56fd\u5185\u5916\u77e5\u540d\u9662\u6821\u7684\u535a\u58eb\u548c\u9ad8\u7ea7\u79d1\u7814\u4eba\u5458\u7b49\u7ec4\u6210\uff0c\u201c\u5728NGS\u8fd9\u4e2a\u9886\u57df\u5185\u5177\u6709\u5c11\u52195\u5e74\u591a\u521910\u5e74\u4ee5\u4e0a\u7684\u4ece\u4e1a\u7ecf\u9a8c\u3002\u201d \u53ef\u4ee5\u9884\u671f\uff0c\u8fd9\u4e9b\u4f18\u52bf\u7684\u53e0\u52a0\u5c06\u4f7f\u5b75\u5316\u5668\u7684\u8d4b\u80fd\u6548\u679c\u66f4\u52a0\u663e\u8457\u3002 \u52a0\u901f\u5408\u4f5c\uff0c\u4ee5\u591a\u7ec4\u5b66\u63a8\u52a8\u65b0\u6280\u672f\u843d\u5730 \u5728\u8fc7\u53bb\uff0c\u8c08\u591a\u7ec4\u5b66\u8d2f\u7a7f\u597d\u50cf\u66f4\u591a\u662f\u4e00\u53e5\u5671\u5934\u3002\u4f46\u968f\u7740\u56f4\u7ed5\u4e2d\u5fc3\u6cd5\u5219\u7684\u5404\u79cd\u7ec4\u5b66\u68c0\u6d4b\u624b\u6bb5\u4e0d\u65ad\u4e30\u5bcc\uff0c\u4eba\u4eec\u6df1\u523b\u611f\u53d7\u5230\u4ee5\u524d\u57fa\u4e8e\u5355\u4e00\u7ec4\u5b66\u5f97\u5230\u7684\u7ed3\u8bba\uff0c\u53ef\u80fd\u662f\u201c\u53ea\u89c1\u6811\u6728\u4e0d\u89c1\u68ee\u6797\u201d\u3002\u201c\u7ec4\u5b66\u201d\u662f\u4e00\u79cd\u6574\u4f53\u7684\u7814\u7a76\u601d\u8def\uff0c\u65e8\u5728\u786e\u5b9a\u503c\u5f97\u9776\u5411\u7814\u7a76\u7684\u4e00\u7cfb\u5217\u6807\u5fd7\u7269\u3002\u4f5c\u4e3a\u591a\u7ec4\u5b66\u7814\u7a76\u548c\u4e34\u5e8a\u670d\u52a1\u63d0\u4f9b\u5546\uff0c\u5e8f\u796f\u8fbe\u6b63\u5728\u9010\u6e10\u4e30\u6ee1\u81ea\u5df1\u7684\u591a\u7ec4\u5b66\u7814\u7a76\u5e73\u53f0\u3002 \u4eca\u5e745\u6708\uff0c\u5e8f\u796f\u8fbe\u4e0eOlink\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u3002\u201c\u5229\u7528\u50cfOlink\u8fd9\u6837\u7684\u6280\u672f\u8fdb\u884c\u86cb\u767d\u7ec4\u5b66\u7684\u6570\u636e\u5206\u6790\uff0c\u8fd9\u5728\u56fd\u5185\u4ecd\u662f\u5c11\u6570\u3002\u201d\u674e\u6e90\u535a\u58eb\u8bf4\uff0c\u201c\u73b0\u9636\u6bb5\uff0c\u86cb\u767d\u7ec4\u5b66\u68c0\u6d4b\u662f\u5e8f\u796f\u8fbe\u91cd\u70b9\u63a8\u5e7f\u7684\u677f\u5757\u4e4b\u4e00\u3002\u4f46\u4f5c\u4e3a\u9ad8\u8d28\u91cf\u591a\u7ec4\u5b66\u670d\u52a1\u5e73\u53f0\uff0c\u5e8f\u796f\u8fbe\u7684\u4e1a\u52a1\u7a81\u7834\u5e76\u4e0d\u4ec5\u4ec5\u4f53\u73b0\u5728\u86cb\u767d\u7ec4\u5b66\u4e0a\u3002\u201d 10\u6708\u5e95\uff0c\u5e8f\u796f\u8fbe\u4e0e\u5355\u7ec6\u80deDNA\u5206\u6790\u548c\u7cbe\u786e\u57fa\u56e0\u7ec4\u5b66\u7684\u5148\u9a71Mission Bio\u8fbe\u6210\u534f\u8bae\uff0c\u6210\u4e3a\u5176\u5728\u4e2d\u56fd\u5730\u533a\u4f18\u9009\u670d\u52a1\u5546\u3002\u53cc\u65b9\u5c06\u5171\u540c\u63a8\u8fdb\u5168\u7403\u8303\u56f4\u5185\u80bf\u7624\u7ec6\u80de\u7597\u6cd5\u9886\u57df\u4e0d\u65ad\u521b\u65b0\uff0c\u5b9e\u73b0\u80bf\u7624\u7cbe\u51c6\u53d1\u73b0\u3001\u7cbe\u51c6\u68c0\u6d4b\u6280\u672f\u3002 \u5165\u9a7b\u4f01\u4e1a\u5728\u5b75\u5316\u5668\u5b9e\u9a8c\u5ba4:\u5de6-\u5e8f\u796f\u8fbe\u603b\u7ecf\u7406\u674e\u6e90\uff1b\u4e2d-\u56e0\u7f8e\u7eb3\u5168\u7403\u521d\u521b\u6276\u6301\u5e73\u53f0\u5927\u4e2d\u534e\u533a\u8d1f\u8d23\u4eba\u6797\u5b50\u5c27\uff1b\u53f3-\u58a8\u5353\u751f\u7269\u521b\u59cb\u4eba\u517c\u9996\u5e2d\u6267\u884c\u5b98 \u674e\u6e90\u535a\u58eb\u79f0\uff0c\u8fd9\u6b21\u80fd\u5165\u9009\u7ea2\u6749\u4e2d\u56fd\u667a\u80fd\u533b\u7597\u57fa\u56e0\u7ec4\u5b66\u5b75\u5316\u5668\uff08\u56e0\u7f8e\u7eb3\u6280\u672f\u9a71\u52a8\uff09\u201c\u611f\u89c9\u53c8\u6269\u5927\u4e86\u4e00\u6279\u6821\u53cb\u201d\uff0c\u4f7f\u5f97\u4e1a\u5185\u540c\u4ec1\u83b7\u5f97\u66f4\u6df1\u5c42\u6b21\u7684\u4ea4\u6d41\u5408\u4f5c\uff0c\u5171\u540c\u63a8\u52a8\u521b\u65b0\u836f\u7269\u7684\u7814\u53d1\u751f\u4ea7\u3002 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