{"id":52637,"date":"2021-11-12T20:59:00","date_gmt":"2021-11-12T13:59:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021111220590052637"},"modified":"2021-11-13T17:53:35","modified_gmt":"2021-11-13T09:53:35","slug":"treadwell-therapeutics%e5%85%ac%e5%8f%b8%e4%ba%8e2021%e5%b9%b4sitc%ef%bc%88%e7%99%8c%e7%97%87%e5%85%8d%e7%96%ab%e6%b2%bb%e7%96%97%e5%ad%a6%e4%bc%9a%ef%bc%89%e5%b9%b4%e4%bc%9a%e4%b8%8a%e5%8f%91","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021111220590052637","title":{"rendered":"Treadwell Therapeutics\u516c\u53f8\u4e8e2021\u5e74SITC\uff08\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u5b66\u4f1a\uff09\u5e74\u4f1a\u4e0a\u53d1\u5e03\u4e00\u4efd\u62a5\u544a\uff0c\u4ecb\u7ecd\u540c\u7c7b\u9996\u521b\u7684HPK1\u6291\u5236\u5242CFI-402411\u7684\u4e34\u5e8a\u8bd5\u9a8c\u8fdb\u5c55"},"content":{"rendered":"<p><p>\u7ebd\u7ea62021\u5e7411\u670812\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 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id=\"spanHghlt16c5\">\u9996\u6b21<\/span>\u5728\u665a\u671f\u5b9e\u4f53\u7624\u8fdb\u884c\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\u3002 <\/p>\n<p>\u52a0\u5dde\u6d1b\u6749\u77f6\u897f\u8fbe\u8d5b\u5948\u9644\u5c5eAngeles\u8bca\u6240\u53ca\u7814\u7a76\u6240\u7684\u7814\u7a76\/\u514d\u75ab\u80bf\u7624\u5b66\u4e3b\u4efbOmid Hamid\u535a\u58eb\u8868\u793a\uff1a\u201cCFI-402411\u662f\u4e00\u79cd\u5f3a\u6548\u53e3\u670dHPK1 (\u9020\u8840\u7956\u7ec6\u80de\u6fc0\u91761\uff0c\u4e5f\u79f0\u4e3a\u4e1d\u88c2\u539f\u6d3b\u5316\u86cb\u767d\u6fc0\u91761\uff0cMAP4K1)\u5c0f\u5206\u5b50\u6291\u5236\u5242\u3002HPK1\u662fT\u7ec6\u80de\u548cB\u7ec6\u80de\u53cd\u5e94\u7684\u8d1f\u8c03\u8282\u56e0\u6570\u3002\u6211\u4eec\u5df2\u7ecf\u770b\u5230\u8fd9\u79cd\u6291\u5236\u5242\u5728\u591a\u53d1\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u7684\u521d\u6b65\u8010\u53d7\u6027\u548c\u4e34\u5e8a\u76ca\u5904\uff0c\u5305\u62ecPD1\u7ecf\u6cbb\u75c5\u4eba\u3002\u201d <\/p>\n<p>Treadwell 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class=\"prntac\"><b>TWT-101\uff1aCFI-402411\uff08\u9020\u8840\u7956\u7ec6\u80de\u6fc0\u9176-1\uff08HPK1\uff09\u6291\u5236\u5242\uff09\u5355\u4e00\u7528\u836f\u4ee5\u53ca\u4e0e\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u6076\u6027\u80bf\u7624\u53d7\u8bd5\u8005\uff0c\u9996\u6b21\u4eba\u4f531\/2\u671f\u7814\u7a76 <br \/><\/b>\u516c\u5f00\u53f7\uff1a489 <br \/>\u6d77\u62a5\u5c55\u793a\u5385 <br \/>\u65f6\u95f4\uff1a2021\u5e7411\u670812\u65e5\uff0c\u4e0a\u53487\uff1a00-8\uff1a30 <\/p>\n<p>\u5728\u6807\u9898\u4e3a\u201c<i>TWT-101\uff1aCFI-402411\uff08\u9020\u8840\u7956\u7ec6\u80de\u6fc0\u9176-1\uff08HPK1\uff09\u6291\u5236\u5242\uff09\u5355\u4e00\u7528\u836f\u4ee5\u53ca\u4e0e\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u6076\u6027\u80bf\u7624\u53d7\u8bd5\u8005\uff0c\u9996\u6b21\u4eba\u4f53 1\/2\u671f\u7814\u7a76<\/i>\u201d\u7684\u5c55\u793a\u62a5\u544a\u4e2d\uff0c\u7531\u63a2\u7d22\u6027\u4f53\u5916SLP-76\u6d4b\u8bd5\u663e\u793a\uff0cCFI-402411\u5728\u5242\u91cf\u6700\u9ad8\u8fbe\u5230400 mg(\u6bcf\u65e5\u4e00\u6b21\u7ed9<span id=\"spanHghltf09d\">\u836f)\u65f6\u5728\u60a3\u8005\u8868\u73b0\u51fa<\/span>\u53ef\u8010\u53d7\u5b89\u5168\u6027\u3001\u7ebf\u6027\u836f\u4ee3\u52a8\u529b\u5b66\u4ee5\u53ca\u751f\u7269\u6709\u6548\u6d53\u5ea6\uff0c\u5728\u8fd9\u7ec4\u7ecf\u8fc7\u5927\u91cf\u6cbb\u7597\u7684\u672a\u9009\u62e9\u60a3\u8005\u7fa4\u4f53\uff08N=16\uff09\u4e2d\uff0c5\u540d\u60a3\u8005\u5728\u81f3\u5c11\u4e00\u6b21\u80bf\u7624\u8bc4\u4f30\u4e2d\u8fbe\u5230\u75c5\u51b5\u7a33\u5b9a\uff0c\u5176\u4e2d2\u540d\u60a3\u8005\uff08\u553e\u6db2\u817a\u548c\u57fa\u5e95\u7ec6\u80de\u764c\uff09\u5728\u81f3\u5c113\u6b21\u80bf\u7624\u8bc4\u4f30\u4e2d\u8fbe\u5230\u75c5\u51b5\u7a33\u5b9a\u3002\u57fa\u5e95\u7ec6\u80de\u764c\u60a3\u8005\u4e4b\u524d\u66fe\u63a5\u53d7\u8fc7\u6297PD1\u6297\u4f53\u6cbb\u7597\u3002\u6700\u5e38\u89c1\u7684\u836f\u7269\u76f8\u5173\u6bd2\u6027 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<\/p>\n<p>CFI-402411\u662f\u4e00\u79cd\u9ad8\u6548\u7684HPK1\u6291\u5236\u5242\uff0c\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u663e\u793a\u5176\u5177\u6709\u514d\u75ab\u542f\u52a8\u4f5c\u7528\uff0c\u5305\u62ec\u51cf\u8f7b\u5bf9T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u7684\u6291\u5236\uff0c\u7834\u574f\u5f02\u5e38\u7ec6\u80de\u56e0\u6570\u7684\u8868\u8fbe\uff0c\u901a\u8fc7\u6548\u5e94\u7ec6\u80de\uff08\u5373\u8c03\u8282\u6027T\u7ec6\u80de\u6216Treg\uff09\u6539\u53d8\u80bf\u7624\u514d\u75ab\u6291\u5236\u73af\u5883\uff0c\u4ee5\u53ca\u5728\u51e0\u79cd\u5c0f\u9f20\u6a21\u578b\u4e2d\u5177\u6709\u5f3a\u5927\u7684\u6297\u767d\u8840\u75c5\u4f5c\u7528\u3002 <\/p>\n<p><b>\u5173\u4e8eTWT-101<\/b> <\/p>\n<p>TWT-101\u662f\u5c06CFI-402411\u7528\u4e8e\u665a\u671f\u5b9e\u4f53\u6076\u6027\u80bf\u7624\u76841\/2\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30CFI-402411\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u3001\u836f\u6548\u5b66\u548c\u7597\u6548\uff0c\u4ee5\u53ca\u786e\u5b9a\u4f5c\u4e3a\u5355\u836f\u6cbb\u7597\u548c\u4e0e\u6297PD1\u6297\u4f53\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u7528\u836f\u7684\u6700\u4f73\u5242\u91cf\u3002\u8be5\u8bd5\u9a8c\u5c06\u5728\u5317\u7f8e\u548c\u4e9a\u6d32\u7684\u591a\u8fbe15\u4e2a\u5730\u70b9\u62db\u52df\u7ea6170\u540d\u60a3\u8005\u3002\u5b83\u5c06\u6d89\u53ca5\u4e2a\u90e8\u5206\uff0c\u5305\u62ec\u5404\u79cd\u7c7b\u578b\u80bf\u7624\u7684\u5355\u836f\u548c\u8054\u5408\u7528\u836f\u7684\u5242\u91cf\u5347\u7ea7\u548c\u6269\u5c55\uff0c\u4ee5\u53ca\u751f\u7269\u6807\u5fd7\u7269\u7684\u56de\u586b\u3002 <\/p>\n<p><b>\u5173\u4e8eTreadwell Therapeutics <\/b><\/p>\n<p>\u9053\u660e\u751f\u7269\u662f\u4e00\u5bb6\u7531\u79d1\u5b66\u9a71\u52a8\uff0c\u4e34\u5e8a\u9636\u6bb5\u6db5\u76d6\u591a\u4e2a\u5206\u5b50\u79cd\u7c7b\u7684\uff0c\u53d1\u6e90\u4e8e\u591a\u4f26\u591a\u5927\u5b66\u9644\u5c5e\u7efc\u5408\u533b\u9662\uff08University Health Network\uff0cUHN\uff09\u7684\u751f\u7269\u79d1\u6280\u516c\u53f8\u3002 \u9053\u660e\u751f\u7269\u4e13\u6ce8\u4e8e\u5f00\u53d1\u5168\u7403\u9996\u521b\u53ca\u540c\u7c7b\u6700\u4f18\u80bf\u7624\u836f\u7269\u6765<span id=\"spanHghlt8c6d\">\u5e2e\u52a9<\/span>\u764c\u75c7\u75c5\u4eba\uff0c\u7531\u5305\u62ec\u9ea6\u5fb7\u534e\u6559\u6388\u5728\u5185\u7684\u591a\u4f4d\u4e16\u754c\u8457\u540d\u79d1\u5b66\u5bb6\u8054\u5408\u521b\u7acb\u3002 \u516c\u53f8\u575a\u5b9e\u7684\u81ea\u8eab\u5f00\u53d1\u7684\u7ba1\u7ebf\u5305\u62ec\u5168\u7403\u9996\u521b\u7684PLK4 \u6fc0\u9176\u6291\u5236\u5242CFI-400945 \uff0c\u53ca\u540c\u7c7b\u6700\u4f18\u7684TTK\u6291\u5236\u5242CFI-402257\uff0c\u4ee5\u53caCFI-402411\uff0c\u53e3\u670d\u7684\u514d\u75ab\u8c03\u8282\u76f8\u5173\u7684HPK1\u6fc0\u9176\u6291\u5236\u5242\u3002 \u9053\u660e\u751f\u7269\u540c\u65f6\u5177\u6709\u591a\u4e2a\u521b\u65b0\u751f\u7269\u836f\u53ca\u4e0b\u4e00\u4ee3TCR\u81ea\u4f53\u7ec6\u80de\u6cbb\u7597\u5e73<span id=\"spanHghlt4394\">\u53f0<\/span>\u7b49\u4e34\u5e8a\u524d\u7ba1\u7ebf\u3002 \u5982\u9700\u4e86\u89e3\u66f4\u591a\u8d44\u8baf\uff0c\u8bf7\u5b58\u53d6<a target=\"_blank\" href=\"http:\/\/www.treadwelltx.com\/\" rel=\"nofollow noopener\">www.treadwelltx.com<\/a>\u3002<\/p>\n<p><b>\u8054\u7edc\u8d44\u8baf<\/b> <\/p>\n<p><u>\u6295\u8d44\u8005\u67e5\u8be2\uff1a<\/u> <br \/>\u5173\u9a8f\u806a <br \/>\u6295\u8d44\u8005\u5173\u7cfb <br \/><a target=\"_blank\" href=\"mailto:ir@treadwelltx.com\" rel=\"nofollow noopener\">ir@treadwelltx.com<\/a>&nbsp;&nbsp; <\/p>\n<p><u>\u666e\u901a\u67e5\u8be2\uff1a<\/u> <br \/><a target=\"_blank\" href=\"mailto:info@treadwelltx.com\" rel=\"nofollow noopener\">info@treadwelltx.com<\/a> &nbsp; <\/p>\n<p>\u76f8\u5173\u94fe\u63a5 :<\/p>\n<blockquote class=\"wp-embedded-content\" data-secret=\"ApeOINQUN0\"><p><a href=\"https:\/\/treadwelltx.com\/\">Home<\/a><\/p><\/blockquote>\n<p><iframe class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; clip: rect(1px, 1px, 1px, 1px);\" title=\"&#8220;Home&#8221; &#8212; Treadwell\" src=\"https:\/\/treadwelltx.com\/embed\/#?secret=ApeOINQUN0\" data-secret=\"ApeOINQUN0\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7ebd\u7ea62021\u5e7411\u670812\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 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