{"id":52201,"date":"2021-11-10T11:07:00","date_gmt":"2021-11-10T04:07:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021111011070052201"},"modified":"2021-11-10T17:56:48","modified_gmt":"2021-11-10T09:56:48","slug":"%e5%86%8d%e9%bc%8e%e5%8c%bb%e8%8d%af%e4%b8%8eblueprint-medicines%e5%85%ac%e5%8f%b8%e5%b0%b1blu-945%e5%8f%8ablu-701%e8%be%be%e6%88%90%e5%9c%a8%e5%a4%a7%e4%b8%ad%e5%8d%8e%e5%8c%ba%e7%9a%84%e6%88%98","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021111011070052201","title":{"rendered":"\u518d\u9f0e\u533b\u836f\u4e0eBlueprint Medicines\u516c\u53f8\u5c31BLU-945\u53caBLU-701\u8fbe\u6210\u5728\u5927\u4e2d\u534e\u533a\u7684\u6218\u7565\u5408\u4f5c\u53ca\u8bb8\u53ef\u534f\u8bae"},"content":{"rendered":"<ul type=\"disc\">\n<li>\u518d\u9f0e\u533b\u836f\u83b7\u5f97\u5728\u5927\u4e2d\u534e\u533a\u72ec\u5bb6\u5f00\u53d1\u548c\u5546\u4e1a\u5316BLU-945\u548cBLU-701\u7684\u6743\u5229 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Medicines\u8fbe\u6210\u5408\u4f5c\uff0c\u63a8\u51fa\u4e24\u4e2a\u5177\u6709\u540c\u7c7b\u9996\u521b\u6f5c\u529b\u3001\u5de7\u5999\u8bbe\u8ba1\u7528\u4e8e\u6cbb\u7597\u6216\u9884\u9632\u9776\u5411\u8010\u836f\u7684EGFR\u6291\u5236\u5242\u3002\u4e2d\u56fd\u6bcf\u5e74\u6709\u8d85\u8fc780\u4e07\u65b0\u786e\u8bca\u80ba\u764c\u60a3\u8005\uff0c\u662f\u5168\u7403EGFR\u7a81\u53d8\u7387\u6700\u9ad8\u7684\u5730\u533a\u4e4b\u4e00\uff0c\u4e14\u76ee\u524d\u5c1a\u65e0\u9488\u5bf9\u524d\u4e00\u4ee3EGFR\u9776\u5411\u6cbb\u7597\u8010\u836f\u7684\u65b0\u7597\u6cd5\u3002\u6211\u4eec\u76f8\u4fe1\u6211\u4eec\u5c06\u6709\u5f88\u5927\u7684\u673a\u4f1a\u6765\u6539\u5584\u4e2d\u56fd\u60a3\u8005\u7684\u6cbb\u7597\u524d\u666f\u3002<sup>[1],[2],[3],[4]<\/sup>\u201d <\/p>\n<p>\u867d\u7136\u9776\u5411\u6cbb\u7597\u6539\u5584\u4e86EGFR\u9a71\u52a8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u6cbb\u7597\uff0c\u4f46\u8010\u836f\u4f9d\u7136\u4e0d\u53ef\u907f\u514d\uff0cT790M\u548cC797S\u662f\u9776\u5411\u6cbb\u7597\u4e2d\u6781\u4e3a\u5e38\u89c1\u7684\u9776\u5411\u8010\u836f\u673a\u5236\u3002\u4e3a\u4e86\u5e94\u5bf9\u8fd9\u4e9b\u6311\u6218\uff0cBLU-945\u548cBLU-701\u6709\u6f5c\u529b\u901a\u8fc7\u5355\u836f\u6216\u8054\u7528\u6cbb\u7597\uff0c\u4ee5\u514b\u670d\u6216\u9884\u9632\u591a\u7ebf\u6cbb\u7597\u7684\u9776\u5411\u8010\u836f\u95ee\u9898\u3002\u6b64\u6b21\u5408\u4f5c\u5c06\u52a0\u901fBLU-945\u548cBLU-701\u7684\u5168\u7403\u5f00\u53d1\uff0c\u5e76\u6709\u6f5c\u529b\u5c06\u6cbb\u7597\u6269\u5c55\u81f3\u66f4\u524d\u7ebf\u7684EGFR\u9a71\u52a8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u3002<\/p>\n<p>BLU-945\u662f\u4e00\u79cd\u9ad8\u9009\u62e9\u6027\u3001\u5f3a\u6548\u7684EGFR\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff0c\u5177\u6709\u5bf9\u6297EGFR\u6fc0\u6d3b\u7a81\u53d8\u548cT790M\u548cC797S\u8010\u836f\u7a81\u53d8\u7684\u6d3b\u6027\u3002\u5b83\u5bf9\u91ce\u751f\u578bEGFR\u548c\u8131\u9776\u6fc0\u9176\u5177\u6709\u9ad8\u5ea6\u9009\u62e9\u6027\uff0c\u7a81\u663e\u4e86\u5176\u8054\u5408\u7528\u836f\u53ef\u8010\u53d7\u6027\u7684\u6f5c\u529b\u3002BLU-945\u76ee\u524d\u6b63\u5728\u5f00\u5c55\u9488\u5bf9\u7ecf\u6cbbEGFR\u9a71\u52a8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u76841\/2\u671fSYMPHONY\u7814\u7a76(NCT04862780)\u3002BLU-701\u662f\u4e00\u79cd\u9ad8\u9009\u62e9\u6027\u3001\u5f3a\u6548\u7684EGFR\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff0c\u5177\u6709\u5bf9\u6297EGFR\u6fc0\u6d3b\u7a81\u53d8\u548cC797S\u8010\u836f\u7a81\u53d8\u7684\u6d3b\u6027\u3002<\/p>\n<p><b>\u5173\u4e8e<\/b><b>EGFR\u9a71\u52a8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u5728\u4e2d\u56fd\u7684\u60c5\u51b5<\/b><\/p>\n<p>\u80ba\u764c\u662f\u4e2d\u56fd\u6700\u5e38\u89c1\u7684\u786e\u8bca\u764c\u75c7\u7c7b\u578b\uff0c\u4e5f\u662f\u764c\u75c7\u7684\u4e3b\u8981\u6b7b\u56e0<sup>[1]<\/sup>\u3002\u4e2d\u56fd\u6bcf\u5e74\u65b0\u53d1\u80ba\u764c\u75c5\u4f8b\u8d85\u8fc780\u4e07\u4f8b\uff0c\u5176\u4e2d\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7ea6\u536085%<sup>[1],[5]<\/sup>\u3002EGFR\u7a81\u53d8\u5728\u4e2d\u56fd\u6bd4\u5728\u7f8e\u56fd\u66f4\u5e38\u89c1\uff0c\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u7ea6\u536040%-50%<sup>[1]<\/sup>\u3002\u5728\u4e2d\u56fd\uff0c\u7b2c\u4e09\u4ee3EGFR\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08\u5982\uff0c\u5965\u5e0c\u66ff\u5c3c\uff09\u5df2\u6210\u4e3a\u4e34\u5e8a\u5e38\u89c4\u7528\u836f\uff0c\u5e76\u9010\u6e10\u6210\u4e3a\u4e00\u7ebf\u6cbb\u7597\u6807\u51c6\u7597\u6cd5\u3002\u7136\u800c\uff0c\u8010\u836f\u4e0d\u53ef\u907f\u514d\u4e14\u4f1a\u5bfc\u81f4\u75be\u75c5\u8fdb\u5c55\u3002\u5bf9\u4e8e\u7b2c\u4e09\u4ee3EGFR\u6291\u5236\u5242\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u60a3\u8005\uff0c\u76ee\u524d\u5c1a\u65e0\u6279\u51c6\u7684\u7597\u6cd5\u3002<\/p>\n<p><b>\u5173\u4e8e<\/b><b>BLU-945\u548cBLU-701<\/b><\/p>\n<p>BLU-945\u548cBLU-701\u6e90\u81eaBlueprint Medicines\u7684\u4e13\u5229\u7814\u7a76\u5e73\u53f0\uff0c\u662f\u5904\u4e8e\u7814\u7a76\u9636\u6bb5\u7684\u65b0\u4e00\u4ee3EGFR\u975e\u5171\u4ef7\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u3002\u8fd9\u4e24\u4e2a\u65b0\u7597\u6cd5\u5747\u8bbe\u8ba1\u7528\u4e8e\u5168\u9762\u8986\u76d6\u6700\u5e38\u89c1\u7684\u6fc0\u6d3b\u548c\u9776\u5411\u8010\u836f\u7a81\u53d8\uff0c\u907f\u5f00\u91ce\u751f\u578bEGFR\u548c\u5176\u4ed6\u6fc0\u9176\u4ee5\u51cf\u5c11\u8131\u9776\u6bd2\u6027\uff0c\u540c\u65f6\u53ef\u4ee5\u5b9e\u73b0\u4e00\u7cfb\u5217\u8054\u7528\u7b56\u7565\uff0c\u5e76\u6cbb\u7597\u6216\u9884\u9632\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u8f6c\u79fb\u3002BLU-945\u76ee\u524d\u6b63\u5728\u5f00\u5c55\u9488\u5bf9\u7ecf\u6cbb\u7684EGFR\u9a71\u52a8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u76841\/2\u671fSYMPHONY\u7814\u7a76(NCT04862780)\u3002\u6b64\u5916\uff0cBlueprint Medicines\u8ba1\u5212\u4e8e2021\u5e74\u7b2c\u56db\u5b63\u5ea6\u542f\u52a8BLU-701\u76841\/2\u671f\u7814\u7a76\u3002<\/p>\n<p><b>\u5173\u4e8e<\/b><b>Blueprint Medicines<\/b><\/p>\n<p>Blueprint Medicines\u662f\u4e00\u5bb6\u4e3a\u764c\u75c7\u548c\u8840\u6db2\u75c5\u60a3\u8005\u53d1\u660e\u53ef\u6539\u53d8\u751f\u547d\u7597\u6cd5\u7684\u5168\u7403\u6027\u7cbe\u51c6\u6cbb\u7597\u516c\u53f8\u3002\u6211\u4eec\u4f7f\u7528\u7cbe\u51c6\u4e14\u7075\u6d3b\u7684\u65b9\u6cd5\u521b\u9020\u9009\u62e9\u6027\u9776\u5411\u9a71\u52a8\u57fa\u56e0\u7684\u836f\u7269\uff0c\u76ee\u6807\u662f\u5728\u75be\u75c5\u53d1\u5c55\u7684\u5404\u4e2a\u9636\u6bb5\u90fd\u53ef\u4ee5\u9886\u5148\u4e8e\u75be\u75c5\u4e00\u6b65\u3002\u81ea2011\u5e74\u4ee5\u6765\uff0c\u6211\u4eec\u5229\u7528\u81ea\u5df1\u7684\u7814\u7a76\u5e73\u53f0\uff0c\u5305\u62ec\u5728\u5206\u5b50\u9776\u5411\u65b9\u9762\u7684\u4e13\u957f\u548c\u4e16\u754c\u4e00\u6d41\u7684\u836f\u7269\u8bbe\u8ba1\u80fd\u529b\uff0c\u5feb\u901f\u5730\u3001\u53ef\u590d\u5236\u5730\u5c06\u79d1\u5b66\u8f6c\u5316\u4e3a\u5e7f\u6cdb\u7684\u7cbe\u51c6\u7597\u6cd5\u4ea7\u54c1\u7ba1\u7ebf\u3002\u73b0\u5728\uff0c\u6211\u4eec\u76f4\u63a5\u5411\u7f8e\u56fd\u548c\u6b27\u6d32\u7684\u60a3\u8005\u63d0\u4f9b\u5df2\u83b7\u6279\u7684\u836f\u7269\uff0c\u5e76\u4e14\u5728\u5168\u7403\u8303\u56f4\u5185\u63a8\u8fdb\u7531\u57fa\u56e0\u5b9a\u4e49\u7684\u80bf\u7624\u3001\u7cfb\u7edf\u6027\u80a5\u5927\u7ec6\u80de\u589e\u591a\u75c7\u548c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u591a\u4e2a\u9879\u76ee\u3002<\/p>\n<p>\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<a target=\"_blank\" href=\"http:\/\/www.blueprintmedicines.com\/\" rel=\"nofollow noopener\">www.BlueprintMedicines.com<\/a>\u5e76\u5728Twitter\uff08@BlueprintMeds\uff09\u548cLinkedIn\u4e0a\u5173\u6ce8\u6211\u4eec\u3002<\/p>\n<p><b>\u5173\u4e8e\u518d\u9f0e\u533b\u836f<\/b><\/p>\n<p>\u518d\u9f0e\u533b\u836f\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aZLAB\uff1b\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a9688\uff09\u662f\u4e00\u5bb6\u4ee5\u60a3\u8005\u4e3a\u4e2d\u5fc3\u7684\u3001\u5904\u4e8e\u5546\u4e1a\u5316\u9636\u6bb5\u7684\u521b\u65b0\u578b\u5168\u7403\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u901a\u8fc7\u521b\u65b0\u7597\u6cd5\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u89e3\u51b3\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u611f\u67d3\u6027\u75be\u75c5\u548c\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u9886\u57df\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u3002\u4e3a\u8fbe\u5230\u8fd9\u4e00\u76ee\u6807\uff0c\u516c\u53f8\u7ecf\u9a8c\u4e30\u5bcc\u7684\u56e2\u961f\u5df2\u4e0e\u5168\u7403\u9886\u5148\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u5efa\u7acb\u4e86\u6218\u7565\u5408\u4f5c\uff0c\u6253\u9020\u8d77\u7531\u521b\u65b0\u7684\u5df2\u4e0a\u5e02\u548c\u5019\u9009\u4ea7\u54c1\u7ec4\u6210\u7684\u4e30\u5bcc\u7684\u4ea7\u54c1\u7ba1\u7ebf\u3002\u518d\u9f0e\u533b\u836f\u5df2\u5efa\u7acb\u8d77\u5177\u6709\u5f3a\u5927\u836f\u7269\u7814\u53d1\u548c\u8f6c\u5316\u7814\u7a76\u80fd\u529b\u7684\u5185\u90e8\u56e2\u961f\uff0c\u6b63\u5728\u6253\u9020\u62e5\u6709\u56fd\u9645\u77e5\u8bc6\u4ea7\u6743\u7684\u5019\u9009\u836f\u7269\u7ba1\u7ebf\u3002\u6211\u4eec\u7684\u613f\u666f\u662f\u6210\u4e3a\u4e00\u5bb6\u9886\u5148\u7684\u5168\u7403\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u7814\u53d1\u3001\u751f\u4ea7\u5e76\u9500\u552e\u521b\u65b0\u4ea7\u54c1\uff0c\u4e3a\u4fc3\u8fdb\u5168\u4e16\u754c\u4eba\u7c7b\u7684\u5065\u5eb7\u798f\u7949\u800c\u52aa\u529b\u3002<\/p>\n<p>\u6709\u5173\u516c\u53f8\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<a target=\"_blank\" href=\"http:\/\/www.zailaborary.com\/\" rel=\"nofollow noopener\">www.zailaborary.com<\/a>\u6216\u5173\u6ce8\u516c\u53f8\u9886\u82f1\u8d26\u53f7\uff1a<a target=\"_blank\" href=\"https:\/\/www.linkedin.com\/company\/zai-lab\/\" rel=\"nofollow noopener\">https:\/\/www.linkedin.com\/company\/zai-lab\/<\/a> \u53ca\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a\u518d\u9f0e\u533b\u836f\u3002<\/p>\n<p>\u53c2\u8003\u8d44\u6599<\/p>\n[1] Zhang YL, Yuan JQ, Wang KF, et al. \u201cThe prevalence of EGFR mutation in patients with non-small cell lung cancer: a systematic review and meta-analysis\u201d. Oncotarget. 2016;7(48):78985-78993. doi:10.18632\/oncotarget.12587<br \/>[2] Zhou J, Song XB, He H, et al. \u201cPrevalence and Clinical Profile of EGFR Mutation In Non- Small-Cell Lung Carcinoma Patients in Southwest China\u201d. Asian Pac J Cancer Prev. 2016;17(3):965-71. doi: 10.7314\/apjcp.2016.17.3.965. PMID: 27039821.<br \/>[3] Wen S, Dai L, Wang L, et al. \u201cGenomic Signature of Driver Genes Identified by Target Next-Generation Sequencing in Chinese Non-Small Cell Lung Cancer\u201d. Oncologist. 2019 Nov;24(11):e1070-e1081. doi: 10.1634\/theoncologist.2018-0572. Epub 2019 Mar 22. PMID: 30902917; PMCID: PMC6853120.<br \/>[4] International Agency for Research on Cancer, Estimated New Incidence in 2020, lung, both sexes, all ages.<br \/>\u56fd\u9645\u764c\u75c7\u7814\u7a76\u673a\u6784\uff0c:2020\u5e74\u4f30\u8ba1\u5168\u5e74\u9f61\u6bb5\u7537\u5973\u65b0\u53d1\u80ba\u764c\u75c5\u4f8b<br \/><a target=\"_blank\" href=\"https:\/\/gco.iarc.fr\/today\/online-analysis-pie?v=2020&amp;mode=population&amp;mode_population=countries&amp;population=900&amp;populations=900&amp;key=total&amp;sex=0&amp;cancer=15&amp;type=0&amp;statistic=5&amp;prevalence=0&amp;population_group=0&amp;ages_group%5B%5D=0&amp;ages_group%5B%5D=17&amp;nb_items=7&amp;group_cancer=1&amp;include_nmsc=1&amp;include_nmsc_other=1&amp;half_pie=0&amp;donut=0%20Accessed%20November%206,%202021\" rel=\"nofollow noopener\">https:\/\/gco.iarc.fr\/today\/online-analysis-pie?v=2020&amp;mode=population&amp;mode_population=countries&amp;population=900&amp;populations=900&amp;key=total&amp;sex=0&amp;cancer=15&amp;type=0&amp;statistic=5&amp;prevalence=0&amp;population_group=0&amp;ages_group%5B%5D=0&amp;ages_group%5B%5D=17&amp;nb_items=7&amp;group_cancer=1&amp;include_nmsc=1&amp;include_nmsc_other=1&amp;half_pie=0&amp;donut=0%20Accessed%20November%206,%202021<\/a> &nbsp;<br \/>2021\u5e7411\u67086\u65e5\u53d1\u5e03.<br \/>[5] Govindan R, Page N, Morgensztern D, et al. \u201cChanging epidemiology of small-cell lung cancer in <span class=\"xn-location\">the United States<\/span> over the last 30 years: analysis of the surveillance, epidemiologic, and end results database.\u201d J Clin Oncol. 2006 <span class=\"xn-chron\">Oct 1<\/span>;24(28):4539-44. doi: 10.1200\/JCO.2005.04.4859. PMID: 17008692.<\/p>\n<p>&nbsp;<\/p>\n<p>\u76f8\u5173\u94fe\u63a5 :<\/p>\n<p>http:\/\/www.zailaborary.com<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u518d\u9f0e\u533b\u836f\u83b7\u5f97\u5728\u5927\u4e2d\u534e\u533a\u72ec\u5bb6\u5f00\u53d1\u548c\u5546\u4e1a\u5316BLU-945\u548cBLU-701\u7684\u6743\u5229 \u5408\u4f5c\u65e8\u5728\u52a0\u901f\u548c\u62d3\u5c55Blueprint Medicines\u7684\u65b0\u4e00\u4ee3EGFR\u6291\u5236\u5242\u7684\u5168\u7403\u5f00\u53d1\uff0c\u8ba1\u5212\u5728\u5927\u4e2d\u534e\u533a\u5f00\u5c55BLU-945\u548cBLU-701\u7684\u4e34\u5e8a\u7814\u7a76 Blueprint Medicines\u5c06\u83b7\u5f972,500\u4e07\u7f8e\u5143\u7684\u9884\u4ed8\u6b3e\uff0c\u53ca\u6f5c\u5728\u91cc\u7a0b\u7891\u4ed8\u6b3e\u548c\u7279\u8bb8\u6743\u4f7f\u7528\u8d39 \u9a6c\u8428\u8bf8\u585e\u5dde\u5251\u6865\u5e02\u3001\u4e2d\u56fd\u4e0a\u6d77\u548c\u7f8e\u56fd\u65e7\u91d1\u5c712021\u5e7411\u670810\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 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