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id=\"spanHghltda17\">\u5927\u4e8e\u7b49\u4e8e<\/span>3\u7ea7TRAE\u4e3a\u8179\u6cfb\uff0c\u7ecf\u95e8\u8bca\u6cbb\u7597\u53ef\u63a7\uff1b\u4f7f\u7528\u6d1b\u54cc\u4e01\u80fa\u9884\u9632\u6cbb\u7597\u540e\uff0c\u7b2c1\u5468\u671f\u7684\u4e8b\u4ef6\u53d1\u751f\u7387\u4ece44%\u964d\u81f318%\u3002\u672a\u89c2\u5bdf\u5230\u91cd\u5ea6\uff08<span id=\"spanHghltda17\">\u5927\u4e8e\u7b49\u4e8e<\/span>3\u7ea7\uff09\u8f93\u6db2\u76f8\u5173\u53cd\u5e94\u6216\u5fc3\u810f\u4e8b\u4ef6\u3002<\/p>\n<p><b>\u5173\u4e8e<\/b><b>Zanidatamab<\/b><\/p>\n<p>Zanidatamab\u662f\u4e00\u79cd\u4f7f\u7528Zymeworks\u7684Azymetric<sup>TM<\/sup>\u5e73\u53f0\u5f00\u53d1\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u53ef\u540c\u65f6\u7ed3\u5408HER2\u7684\u4e24\u4e2a\u975e\u91cd\u53e0\u8868\u4f4d\uff0c\u5373\u53cc\u4e92\u8865\u4f4d\u7ed3\u5408\u3002\u8fd9\u79cd\u72ec\u7279\u7684\u7ed3\u5408\u7279\u6027\u53ef\u5f62\u6210\u591a\u79cd\u4f5c\u7528\u673a\u5236\uff0c\u5305\u62ecHER2\u53d7\u4f53\u805a\u96c6\u3001\u5185\u5316\u548c\u4e0b\u8c03\uff1b\u6291\u5236\u751f\u957f\u56e0\u5b50\u4f9d\u8d56\u6027\u548c\u975e\u4f9d\u8d56\u6027\u80bf\u7624\u7ec6\u80de\u589e\u6b96\uff1b\u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u6bd2\u6027\u548c\u541e\u566c\u4f5c\u7528\uff1b\u4ee5\u53ca\u8865\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u6bd2\u6027\u3002Zymeworks\u6b63\u5728\u5168\u7403\u8303\u56f4\u5185\u901a\u8fc7\u591a\u4e2a1\u671f\u30012\u671f\u548c\u6ce8\u518c\u6027\u4e34\u5e8a\u8bd5\u9a8c\u5f00\u53d1Zanidatamab\uff0c\u81f4\u529b\u4e8e\u4e3a\u8868\u8fbeHER2\u7684\u5b9e\u4f53\u7624\u60a3\u8005\u63d0\u4f9b\u9776\u5411\u6cbb\u7597\u9009\u62e9\u3002\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u6388\u4e88Zanidatamab\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff0c\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u7ecf\u6cbb\u7684HER2\u57fa\u56e0\u6269\u589e\u80c6\u9053\u764c\uff08BTC\uff09\u60a3\u8005\uff0c\u5e76\u6388\u4e88Zanidatamab\u4e24\u9879\u5feb\u901f\u901a\u9053\u8ba4\u5b9a\uff0c\u4f5c\u4e3a\u5355\u836f\u6cbb\u7597\u7528\u4e8e\u96be\u6cbb\u6027BTC\uff0c\u4ee5\u53ca\u8054\u5408\u5316\u7597\u6807\u51c6\u7597\u6cd5\u7528\u4e8e\u80c3\u98df\u7ba1\u817a\u764c\uff08GEA\uff09\u7684\u4e00\u7ebf\u6cbb\u7597\u3002\u8fd9\u4e9b\u8ba4\u5b9a\u8868\u660eZanidatamab\u6709\u8d44\u683c\u53c2\u4e0e\u52a0\u901f\u6279\u51c6\u3001\u4f18\u5148\u5ba1\u8bc4\u548c\u6eda\u52a8\u5ba1\u8bc4\uff0c\u53ef\u63a5\u53d7FDA\u5173\u4e8e\u9ad8\u6548\u836f\u7269\u5f00\u53d1\u8ba1\u5212\u7684\u6df1\u5165\u6307\u5bfc\u3002\u6b64\u5916\uff0cZanidatamab\u5df2\u83b7FDA\u5b64\u513f\u836f\u8ba4\u5b9a\uff0c\u7528\u4e8e\u6cbb\u7597\u80c6\u9053\u764c\u3001\u80c3\u764c\u548c\u5375\u5de2\u764c\uff0c\u5e76\u83b7\u5f97\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\u5b64\u513f\u836f\u8ba4\u5b9a\uff0c\u7528\u4e8e\u6cbb\u7597\u80c6\u9053\u764c\u548c\u80c3\u764c\u3002<\/p>\n<p><b>\u5173\u4e8e<\/b><b>Zymeworks<\/b><b>\u4e0e\u767e\u6d4e\u795e\u5dde\u7684\u5408\u4f5c<\/b><\/p>\n<p>2018\u5e7411\u6708\uff0cZymeworks\u4e0e\u767e\u6d4e\u795e\u5dde\u8fbe\u6210\u6388\u6743\u4e0e\u5408\u4f5c\u534f\u8bae\uff0c\u767e\u6d4e\u795e\u5dde\u83b7\u5f97Zanidatamab\u548cZW49\u5728\u4e9a\u6d32\uff08\u4e0d\u5305\u62ec\u65e5\u672c\uff09\u3001\u6fb3\u5927\u5229\u4e9a\u548c\u65b0\u897f\u5170\u7684\u72ec\u5bb6\u7814\u7a76\u3001\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6388\u6743\u3002\u4e24\u5bb6\u516c\u53f8\u6b63\u5728\u5408\u4f5c\u8fdb\u884c\u5168\u7403\u8054\u5408\u5f00\u53d1\u9009\u5b9a\u7684\u9002\u5e94\u75c7\uff0c\u65e8\u5728\u5168\u7403\u8303\u56f4\u5185\u5f00\u53d1Zanidatamab\u548cZW49\u7528\u4e8e\u591a\u79cd\u8868\u8fbeHER2\u7684\u764c\u75c7\u548c\u6cbb\u7597\u7ebf\u3002<\/p>\n<p><b>\u5173\u4e8e<\/b><b>Zymeworks Inc.<\/b><\/p>\n<p>Zymeworks\u662f\u4e00\u5bb6\u4e34\u5e8a\u9636\u6bb5\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u65b0\u4e00\u4ee3\u591a\u529f\u80fd\u751f\u7269\u7597\u6cd5\u3002Zymeworks\u7684\u6cbb\u7597\u5e73\u53f0\u53ca\u5176\u7efc\u5408\u6027\u7684\u836f\u7269\u5f00\u53d1\u7cfb\u7edf\u80fd\u591f\u7cbe\u51c6\u5f00\u53d1\u9ad8\u5ea6\u5dee\u5f02\u5316\u7684\u5019\u9009\u836f\u7269\u3002Zymeworks\u7684\u4e3b\u8981\u4e34\u5e8a\u5019\u9009\u836f\u7269Zanidatamab\u662f\u4e00\u6b3e\u4f7f\u7528Azymetric<sup>TM<\/sup>\u5f00\u53d1\u7684\u9776\u5411HER2\u7684\u65b0\u578b\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u76ee\u524d\u6709\u4e24\u9879\u5173\u952e\u6027\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u60a3\u8005\u5165\u7ec4\u9636\u6bb5\uff0c\u4e00\u9879\u7528\u4e8e\u6cbb\u7597HER2\u9633\u6027\u80c3\u98df\u7ba1\u817a\u764c\uff08HERIZON-GEA-01\uff09\uff0c\u4e00\u9879\u7528\u4e8e\u6cbb\u7597\u96be\u6cbb\u6027HER2\u6269\u589e\u80c6\u9053\u764c\uff08HERIZON-BTC-01\uff09\uff0c\u540e\u8005\u5df2\u83b7FDA\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u3002\u76ee\u524d\u6b63\u5728\u6570\u98792\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8bc4\u4ef7Zanidatamab\u7528\u4e8e\u6cbb\u7597\u8868\u8fbeHER2\u7684\u80c3\u98df\u7ba1\u764c\u3001\u7ed3\u80a0\u76f4\u80a0\u764c\u548c\u4e73\u817a\u764c\u3002Zymeworks\u7684\u7b2c\u4e8c\u6b3e\u4e34\u5e8a\u5019\u9009\u836f\u7269ZW49\u662f\u4e00\u79cd\u9776\u5411HER2\u7684\u65b0\u578b\u53cc\u7279\u5f02\u6027\u6297\u4f53-\u836f\u7269\u5076\u8054\u7269\uff0c\u76ee\u524d\u6b63\u59041\u671f\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\uff0c\u5176\u7ed3\u5408\u4e86Zanidatamab\u7684\u72ec\u7279\u8bbe\u8ba1\u548c\u6297\u4f53\u6846\u67b6\u4ee5\u53caZymeworks\u7684\u4e13\u5229ZymeLink&#x2122;\u8fde\u63a5\u5b50\u548c\u7ec6\u80de\u6bd2\u7d20\u3002Zymeworks\u8fd8\u5728\u80bf\u7624\u9886\u57df\uff08\u5305\u62ec\u514d\u75ab\u80bf\u7624\u836f\u7269\uff09\u548c\u5176\u4ed6\u6cbb\u7597\u9886\u57df\u6df1\u5165\u63a8\u8fdb\u4e34\u5e8a\u524d\u7ba1\u7ebf\u5f00\u53d1\u3002\u6b64\u5916\uff0c\u5176\u6cbb\u7597\u5e73\u53f0\u6b63\u901a\u8fc7\u4e0e9\u5bb6\u751f\u7269\u5236\u836f\u516c\u53f8\u7684\u6218\u7565\u5408\u4f5c\u4f19\u4f34\u5173\u7cfb\u5f97\u5230\u8fdb\u4e00\u6b65\u4f7f\u7528\u3002\u82e5\u9700\u6709\u5173Zymeworks\u7684\u5176\u4ed6\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<a target=\"_blank\" href=\"http:\/\/www.zymeworks.com\/\" rel=\"nofollow noopener\">www.zymeworks.com<\/a>\uff0c\u6216\u5728Twitter\u4e0a\u5173\u6ce8<a target=\"_blank\" href=\"https:\/\/twitter.com\/ZymeworksInc\" rel=\"nofollow noopener\">@ZymeworksInc<\/a>\u3002<\/p>\n<p><b>\u5173\u4e8e\u524d\u77bb\u6027\u58f0\u660e\u7684\u6ce8\u610f\u4e8b\u9879<\/b><\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u5305\u542b\u7f8e\u56fd1995\u5e74\u300a\u79c1\u4eba\u8bc1\u5238\u8bc9\u8bbc\u6539\u9769\u6cd5\u6848\u300b\u6240\u5b9a\u4e49\u7684\u201c\u524d\u77bb\u6027\u58f0\u660e\u201d\u548c\u52a0\u62ff\u5927\u8bc1\u5238\u6cd5\u6240\u5b9a\u4e49\u7684\u201c\u524d\u77bb\u6027\u4fe1\u606f\u201d\uff0c\u6216\u7edf\u79f0\u4e3a\u524d\u77bb\u6027\u58f0\u660e\u3002\u672c\u65b0\u95fb\u7a3f\u4e2d\u7684\u524d\u77bb\u6027\u58f0\u660e\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u4e0eZymeworks\u5019\u9009\u4ea7\u54c1\u7684\u4e34\u5e8a\u5f00\u53d1\u3001\u76f8\u5173\u4e34\u5e8a\u8bd5\u9a8c\u3001\u9884\u671f\u7684\u4e34\u5e8a\u6570\u636e\u5c55\u793a\u3001Zanidatamab\u7684\u6f5c\u5728\u6cbb\u7597\u6548\u679c\u3001Zymeworks\u7684\u4e34\u5e8a\u524d\u7ba1\u7ebf\u6709\u5173\u7684\u58f0\u660e\u4ee5\u53ca\u5176\u4ed6\u975e\u5386\u53f2\u6027\u4fe1\u606f\u3002\u672c\u65b0\u95fb\u7a3f\u4e2d\u4f7f\u7528\u201c\u8ba1\u5212\u201d\u3001\u201c\u9884\u8ba1\u201d\u3001\u201c\u53ef\u80fd\u201d\u3001\u201c\u6f5c\u5728\u201d\u3001\u201c\u5c06\u201d\u3001\u201c\u76ee\u6807\u201d\u7b49\u8bcd\u6c47\u548c\u7c7b\u4f3c\u8868\u8fbe\u65f6\uff0c\u5747\u65e8\u5728\u8868\u793a\u524d\u77bb\u6027\u58f0\u660e\u3002\u6b64\u5916\uff0c\u4efb\u4f55\u6d89\u53ca\u9884\u671f\u3001\u89c2\u70b9\u3001\u8ba1\u5212\u3001\u9884\u6d4b\u3001\u76ee\u6807\u3001\u8868\u73b0\u7684\u58f0\u660e\u6216\u4fe1\u606f\uff0c\u6216\u5176\u4ed6\u5bf9\u4e8e\u672a\u6765\u4e8b\u4ef6\u6216\u60c5\u51b5\u7684\u63cf\u8ff0\uff0c\u5305\u62ec\u4efb\u4f55\u9690\u542b\u7684\u5047\u8bbe\uff0c\u5747\u5177\u6709\u524d\u77bb\u6027\u3002\u6240\u6709\u524d\u77bb\u6027\u58f0\u660e\u5747\u57fa\u4e8eZymeworks\u5f53\u524d\u7684\u9884\u671f\u548c\u5404\u79cd\u5047\u8bbe\u3002Zymeworks\u8ba4\u4e3a\uff0c\u5176\u9884\u671f\u548c\u89c2\u70b9\u5177\u6709\u5408\u7406\u7684\u57fa\u7840\uff0c\u4f46\u5fc5\u5b9a\u5b58\u5728\u4e0d\u786e\u5b9a\u6027\u3002Zymeworks\u53ef\u80fd\u65e0\u6cd5\u5b9e\u73b0\u5176\u9884\u671f\uff0c\u5176\u89c2\u70b9\u4e5f\u53ef\u80fd\u65e0\u6cd5\u88ab\u8bc1\u660e\u662f\u6b63\u786e\u7684\u3002\u7531\u4e8e\u5404\u79cd\u56e0\u7d20\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u5e02\u573a\u6761\u4ef6\u53caZymeworks\u9488\u5bf92021\u5e746\u670830\u65e5\u7ed3\u675f\u7684\u5b63\u5ea6\u6240\u53d1\u5e03\u768410-Q\u8868\u683c\u5b63\u5ea6\u62a5\u544a\uff08\u526f\u672c\u53ef\u5728www.sec.gov\u548c<a target=\"_blank\" href=\"http:\/\/www.sedar.com\/\" rel=\"nofollow noopener\">www.sedar.com<\/a>\u83b7\u5f97\uff09\u4e2d\u201c\u98ce\u9669\u56e0\u7d20\u201d\u7ae0\u8282\u4e0b\u63cf\u8ff0\u7684\u56e0\u7d20\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4e0e\u6b64\u7c7b\u524d\u77bb\u6027\u58f0\u660e\u4e2d\u63cf\u8ff0\u6216\u9690\u542b\u7684\u7ed3\u679c\u5b58\u5728\u5b9e\u8d28\u6027\u5dee\u5f02\u3002\u56e0\u6b64\uff0c\u524d\u77bb\u6027\u58f0\u660e\u5e94\u4ec5\u89c6\u4e3aZymeworks\u5f53\u524d\u7684\u8ba1\u5212\u3001\u4f30\u8ba1\u548c\u89c2\u70b9\u3002\u6295\u8d44\u8005\u4e0d\u5e94\u8fc7\u5ea6\u4f9d\u8d56\u524d\u77bb\u6027\u58f0\u660e\u3002Zymeworks\u4e0d\u80fd\u4fdd\u8bc1\u672a\u6765\u7684\u7ed3\u679c\u3001\u4e8b\u4ef6\u3001\u6d3b\u52a8\u6c34\u5e73\u3001\u8868\u73b0\u6216\u6210\u5c31\u3002\u9664\u6cd5\u5f8b\u7684\u8981\u6c42\u5916\uff0cZymeworks\u65e0\u8d23\u4efb\u4e14\u660e\u786e\u62d2\u7edd\u4efb\u4f55\u66f4\u65b0\u3001\u91cd\u65b0\u53d1\u5e03\u6216\u4fee\u8ba2\u4efb\u4f55\u524d\u77bb\u6027\u58f0\u660e\u4ee5\u53cd\u6620\u65b0\u4fe1\u606f\u3001\u672a\u6765\u4e8b\u4ef6\u6216\u60c5\u51b5\u6216\u53cd\u6620\u975e\u9884\u671f\u4e8b\u4ef6\u53d1\u751f\u60c5\u51b5\u3002<\/p>\n<p>\u76f8\u5173\u94fe\u63a5 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