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\u4e0a\u6d772021\u5e7410\u670826\u65e5 \/\u7f8e\u901a\u793e\/ — 2021\u5e7410\u670825\u65e5\uff0c\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5ba3\u5e03\uff0c\u5df2\u6b63\u5f0f\u5411\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08<\/b>CDE\uff09\u9012\u4ea4\u514d\u75ab\u65b0\u836fSpesolimab\u7684\u4e0a\u5e02\u7533\u8bf7\uff0c\u7528\u4e8e\u6cbb\u7597\u6cdb\u53d1\u6027\u8113\u75b1\u578b\u94f6\u5c51\u75c5\uff08GPP\uff09\u7684\u53d1\u4f5c<\/b>\u3002\u6b64\u524d\uff0c\u57fa\u4e8eSpesolimab\u5728\u5176\u6cbb\u7597GPP I\u671f\u548cII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684\u4f18\u8d8a\u8868\u73b0\uff0cCDE\u5df2\u4e8e\u4eca\u5e746\u670825\u65e5\u6388\u4e88Spesolimab\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u8ba4\u5b9a\u3002<\/p>\n

GPP\u662f\u4e00\u79cd\u7f55\u89c1\u7684\u3001\u590d\u53d1\u6027\u6216\u6301\u7eed\u53d1\u4f5c\u7684\u76ae\u80a4\u75be\u75c5[i,ii]<\/sup>\uff0c<\/span>\u636e\u7edf\u8ba1\uff0c\u5728\u4e2d\u56fd\u7ea6100,000\u4eba\u4e2d\u4ec5\u67091~2\u4eba\u60a3GPP[iii]<\/sup>\u3002<\/span>GPP\u4e0d\u540c\u4e8e\u5bfb\u5e38\u578b\u94f6\u5c51\u75c5\uff0c\u4ece\u4e34\u5e8a\u8868\u73b0\u770b\uff0c\u4e24\u79cd\u75be\u75c5\u5747\u53ef\u80fd\u8868\u73b0\u4e3a\u76ae\u80a4\u5927\u9762\u79ef\u53d1\u7ea2\u3001\u53d1\u75d2\u3001\u6781\u5ea6\u5e72\u71e5\u3001\u76b2\u88c2\u53ca\u5448\u9cde\u72b6\uff0c\u4f46GPP\u60a3\u8005\u975e\u80a2\u7aef\u76ae\u80a4\u4f1a\u5e7f\u6cdb\u51fa\u73b0\u5145\u6ee1\u8113\u6db2\u7684\u6c34\u6ce1\uff08\u8113\u75b1\uff09\uff0c\u5e76\u6709\u75db\u611f\uff0c\u800c\u4e14\u53ef\u80fd\u4f34\u53d1\u9ad8\u70ed\u7b49\u5168\u8eab\u75c7\u72b6\uff0c\u751a\u81f3\u53ef\u5f15\u8d77\u5371\u53ca\u751f\u547d\u7684\u5668\u5b98\u8870\u7aed\u548c\u611f\u67d3\u5e76\u53d1\u75c7\u3002\u622a\u81f3\u76ee\u524d\uff0cGPP\u7684\u786e\u5207\u75c5\u56e0\u5c1a\u4e0d\u6e05\u695a\uff0c\u6cbb\u7597\u65b9\u6848\u4e5f\u6781\u4e3a\u6709\u9650\uff0c\u4e14\u8fd8\u6ca1\u6709\u516c\u8ba4\u7684\u8bca\u7597\u6807\u51c6\u3002<\/p>\n

\u8fd1\u4e9b\u5e74\u6765\uff0c\u6709\u7814\u7a76\u53d1\u73b0\u8113\u75b1\u578b\u94f6\u5c51\u75c5\u4e0e\u767d\u7ec6\u80de\u4ecb\u7d20-36\uff08IL-36\uff09\u901a\u8def\u76f8\u5173\u3002Spesolimab\u662f\u4e00\u6b3e\u963b\u65adIL-36\u53d7\u4f53\u7684\u5355\u514b\u9686\u6297\u4f53\uff0c\u4f5c\u4e3a\u540c\u7c7b\u9996\u4e2a\u5728\u7814\u7684\u6cbb\u7597\u624b\u6bb5\uff0c\u8be5\u836f\u7528\u4e8e\u6cbb\u7597GPP\u53d1\u4f5c\u60a3\u8005\u7684\u4e0a\u5e02\u7533\u8bf7\u662f\u57fa\u4e8e\u5176\u5168\u7403\u5173\u952e\u6027II\u671f\u4e34\u5e8a\u7814\u7a76\u3002\u5176\u7814\u7a76\u5173\u952e\u7ed3\u679c\u663e\u793a\uff1a54.3%\u7684\u60a3\u8005\u7ecfSpesolimab\u6cbb\u75971\u5468\u4fbf\u8fbe\u5230\u76ae\u80a4\u65e0\u53ef\u89c1\u8113\u75b1\uff1b42.9%\u7684\u60a3\u8005\u7ecfSpesolimab\u6cbb\u75971\u5468\u53ef\u8fbe\u5230\u76ae\u80a4\u75c7\u72b6\u6e05\u9664\u6216\u51e0\u4e4e\u6e05\u9664\u3002<\/b>\u540c\u65f6\u5728\u6574\u4e2a\u7814\u7a76\u4e2d\uff0cSpesolimab\u7684\u5b89\u5168\u6027\u6570\u636e\u662f\u53ef\u63a5\u53d7\u7684\uff0c\u60a3\u8005\u5e38\u89c1\u7684\u4e0d\u826f\u4e8b\u4ef6\u5305\u62ec\u53d1\u70ed\u548c\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\u611f\u67d3\u3002<\/p>\n

\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5927\u4e2d\u534e\u533a\u533b\u5b66\u548c\u4e34\u5e8a\u7814\u53d1\u8d1f\u8d23\u4eba\u5f20\u7ef4\u535a\u58eb\u8868\u793a\uff1a\u201c\u6211\u4eec\u4e00\u76f4\u81f4\u529b\u4e8e\u52a0\u901f\u5168\u7403\u521b\u65b0\u836f\u5728\u4e2d\u56fd\u843d\u5730\uff0c\u8ba9\u4e2d\u56fd\u60a3\u8005\u5c3d\u65e9\u4ece\u4e2d\u83b7\u76ca\u3002\u5f97\u76ca\u4e8e\u4e2d\u56fd\u65b0\u836f\u5ba1\u6279\u5236\u5ea6\u7684\u6539\u9769\u4ee5\u53ca\u516c\u53f8\u2018\u4e2d\u56fd\u5173\u952e\u2019\u9879\u76ee\u7684\u5b9e\u65bd\uff0c\u4e2d\u56fd\u53c2\u4e0e\u5e76\u987a\u5229\u5b8c\u6210\u4e86Spesolimab\u5168\u7403\u5173\u952e\u6027II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4f7f\u6211\u4eec\u5728\u4e2d\u56fd\u5f97\u4ee5\u4e0e\u5168\u7403\u540c\u6b65\u9012\u4ea4Spesolimab\u7528\u4e8e\u6cbb\u7597GPP\u53d1\u4f5c\u9002\u5e94\u75c7\u7684\u4e0a\u5e02\u7533\u8bf7\u3002\u6211\u4eec\u671f\u5f85\u7740\u4e0e\u76f8\u5173\u90e8\u95e8\u7d27\u5bc6\u5408\u4f5c\uff0c\u63a8\u52a8\u8be5\u9002\u5e94\u75c7\u65e9\u65e5\u5728\u4e2d\u56fd\u83b7\u6279\uff0c\u8ba9\u4e2d\u56fdGPP\u60a3\u8005\u53ef\u4ee5\u2018\u96f6\u65f6\u5dee\u2019\u7528\u4e0a\u6539\u53d8\u751f\u547d\u7684\u521b\u65b0\u836f\u3002\u201d<\/p>\n

\n\n\n\n\n\n
\n

i.   Kharawala S, et al. The clinical, humanistic, and economic burden of generalized pustular psoriasis: a structured review. Exp Rev Clin Immunol<\/i>. 2020;16(3):239-252. <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

ii.    Bachelez, H. Pustular psoriasis: the dawn of a new era. Acta Derm Venereol<\/i>. 2020;100(3):adv000343<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

iii.  \u300a\u6211\u56fd\u6cdb\u53d1\u6027\u8113\u75b1\u578b\u94f6\u5c51\u75c5\u7684\u60a3\u75c5\u7387\u548c\u75be\u75c5\u8d1f\u62c5\u8c03\u67e5\uff1a\u4e00\u9879\u57fa\u4e8e\u5168\u56fd2012-2016\u5e74\u57ce\u9547\u533b\u7597\u4fdd\u9669\u6570\u636e\u7684\u4f30\u7b97\u300b\uff0c\u4e2d\u534e\u533b\u5b66\u4f1a\u7b2c\u4e8c\u5341\u4e03\u6b21\u5168\u56fd\u76ae\u80a4\u6027\u75c5\u5b66\u5b66\u672f\u5e74\u4f1a\uff0c2021\u5e746\u6708<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

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The clinical, humanistic, and economic burden of generalized pustular psoriasis: a structured review. Exp Rev Clin Immunol. 2020;16(3):239-252. ii.    Bachelez, H. Pustular psoriasis: the dawn of a new era. Acta Derm Venereol. 2020;100(3):adv000343 iii.  \u300a\u6211\u56fd\u6cdb\u53d1\u6027\u8113\u75b1\u578b\u94f6\u5c51\u75c5\u7684\u60a3\u75c5\u7387\u548c\u75be\u75c5\u8d1f\u62c5\u8c03\u67e5\uff1a\u4e00\u9879\u57fa\u4e8e\u5168\u56fd2012-2016\u5e74\u57ce\u9547\u533b\u7597\u4fdd\u9669\u6570\u636e\u7684\u4f30\u7b97\u300b\uff0c\u4e2d\u534e\u533b\u5b66\u4f1a\u7b2c\u4e8c\u5341\u4e03\u6b21\u5168\u56fd\u76ae\u80a4\u6027\u75c5\u5b66\u5b66\u672f\u5e74\u4f1a\uff0c2021\u5e746\u6708  … Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":8278,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-49601","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/49601","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=49601"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/49601\/revisions"}],"predecessor-version":[{"id":49602,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/49601\/revisions\/49602"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/8278"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=49601"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=49601"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=49601"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}