{"id":46722,"date":"2021-10-02T07:30:00","date_gmt":"2021-10-02T00:30:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021100207300046722"},"modified":"2021-10-02T17:53:04","modified_gmt":"2021-10-02T09:53:04","slug":"%e5%9f%ba%e7%9f%b3%e8%8d%af%e4%b8%9a%e5%9c%a82021%e5%b9%b4%e7%ac%ac90%e5%b1%8a%e7%be%8e%e5%9b%bd%e7%94%b2%e7%8a%b6%e8%85%ba%e5%8d%8f%e4%bc%9a%e5%b9%b4%e5%ba%a6%e4%bc%9a%e8%ae%ae%e4%b8%8a%e4%bb%a5","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021100207300046722","title":{"rendered":"\u57fa\u77f3\u836f\u4e1a\u57282021\u5e74\u7b2c90\u5c4a\u7f8e\u56fd\u7532\u72b6\u817a\u534f\u4f1a\u5e74\u5ea6\u4f1a\u8bae\u4e0a\u4ee5\u53e3\u5934\u62a5\u544a\u5f62\u5f0f\u9996\u6b21\u516c\u5e03\u666e\u5409\u534e\u00aeARROW\u7814\u7a76\u4e2dRET\u7a81\u53d8\u7532\u72b6\u817a\u9ad3\u6837\u764c\u4e2d\u56fd\u60a3\u8005\u6570\u636e"},"content":{"rendered":"<ul type=\"disc\">\n<li>\u4e3b\u8981\u7597\u6548\u6570\u636e\u663e\u793a\uff1a\u666e\u5409\u534e<sup>&reg;<\/sup>\u5728\u665a\u671f\u6216\u8f6c\u79fb\u6027\u8f6c\u67d3\u91cd\u6392\uff08RET\uff09\u7a81\u53d8\u7532\u72b6\u817a\u9ad3\u6837\u764c(MTC)\u4e2d\u56fd\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u4e86\u4f18\u8d8a\u548c\u6301\u4e45\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u786e\u8ba4\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u8fbe\u523073.1%\uff0c9\u4e2a\u6708\u7684\u7f13\u89e3\u6301\u7eed\u7387(DOR)\u4e3a100% <\/li>\n<li>2021\u5e744\u6708\uff0c\u666e\u5409\u534e<sup>&reg;<\/sup>\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u6216\u8f6c\u79fb\u6027RET\u7a81\u53d8MTC\u548c\u665a\u671f\u6216\u8f6c\u79fb\u6027RET\u878d\u5408\u9633\u6027\u7532\u72b6\u817a\u764c\u60a3\u8005\u7684\u9002\u5e94\u75c7\u5df2\u7ecf\u83b7\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40(NMPA)\u53d7\u7406\u5e76\u88ab\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4<\/li>\n<\/ul>\n<p><p>\u4e2d\u56fd\u82cf\u5dde2021\u5e7410\u67082\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u57fa\u77f3\u836f\u4e1a (\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a2616) \uff0c\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u7814\u7a76\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u521b\u65b0\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u53ca\u7cbe\u51c6\u6cbb\u7597\u836f\u7269\u7684\u9886\u5148\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\uff0c\u57282021\u5e74\u7b2c 90 \u5c4a\u7f8e\u56fd\u7532\u72b6\u817a\u534f\u4f1a\u5e74\u5ea6\u4f1a\u8bae(The 90th Annual Meeting of the American Thyroid Association 2021) \u4e0a\uff0c\u9009\u62e9\u6027RET\u6291\u5236\u5242\u666e\u5409\u534e<sup>&reg;<\/sup>\uff08\u666e\u62c9\u66ff\u5c3c\u80f6\u56ca\uff09\u5728\u5168\u7403I\/II\u671fARROW\u8bd5\u9a8c\u4e2d\u6cbb\u7597\u665a\u671f\u6216\u8f6c\u79fb\u6027RET\u7a81\u53d8MTC\u4e2d\u56fd\u60a3\u8005\u7684\u6ce8\u518c\u7814\u7a76\u6570\u636e\u4ee5\u91cd\u78c5\u53e3\u5934\u62a5\u544a(Late Breaking Oral )\u5f62\u5f0f\u516c\u5e03\u4e86\u8be6\u7ec6\u6570\u636e\u3002\u7814\u7a76\u6570\u636e\u663e\u793a\uff0c\u666e\u5409\u534e<sup>&reg;<\/sup>\u5728\u9700\u8981\u7cfb\u7edf\u6027\u6cbb\u7597\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027RET\u7a81\u53d8MTC\u4e2d\u56fd\u60a3\u8005\u4e2d\uff0c\u663e\u793a\u51fa\u4e86\u5e7f\u6cdb\u548c\u6301\u4e45\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u4e0e\u4ee5\u5f80\u62a5\u9053\u7684ARROW\u5168\u7403\u4eba\u7fa4\u4e00\u81f4\u3002\u6574\u4f53\u5b89\u5168\u53ef\u63a7\uff0c\u4e14\u6ca1\u6709\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u4fe1\u53f7\u3002<\/p>\n<ul type=\"disc\">\n<li>\u7814\u7a76\u9886\u57df\uff1a\u7532\u72b6\u817a\u764c <\/li>\n<li>\u65e5\u671f\uff1a2021\u5e7410\u67082\u65e500:00-1:00 (\u5317\u4eac\u65f6\u95f4) <\/li>\n<li>\u62a5\u544a\u5f62\u5f0f\uff1a\u4e34\u5e8a\u53e3\u5934\u62a5\u544a\u6458\u8981\u73af\u8282 <\/li>\n<li>\u9898\u76ee\uff1a\u9009\u62e9\u6027RET\u6291\u5236\u5242\u666e\u62c9\u66ff\u5c3c\u6cbb\u7597\u665a\u671fRET\u7a81\u53d8MTC\u7684\u7597\u6548\u548c\u5b89\u5168\u6027 <\/li>\n<li>\u62a5\u544a\u7f16\u53f7\uff1a&nbsp;Late Breaking Oral 3 <\/li>\n<li>\u4e3b\u8981\u7814\u7a76\u8005\uff1a\u5929\u6d25\u5e02\u4eba\u6c11\u533b\u9662\u9662\u957f \u9ad8\u660e \u6559\u6388 <\/li>\n<li>\u62a5\u544a\u4eba\uff1a\u5929\u6d25\u533b\u79d1\u5927\u5b66\u80bf\u7624\u533b\u9662 \u90d1\u5411\u524d \u6559\u6388<\/li>\n<\/ul>\n<p>\u622a\u81f3\u6570\u636e\u622a\u6b62\u65e5\u671f\uff082021\u5e744\u670812\u65e5\uff09\uff0c\u5171\u6709\u6765\u81ea\u4e2d\u56fd\u7814\u7a76\u4e2d\u5fc3\u768428\u4f8bRET\u7a81\u53d8\u9633\u6027MTC\u60a3\u8005\u7eb3\u5165\u4e86\u5168\u7403ARROW\u7814\u7a76\u4e2d\u56fdMTC\u6ce8\u518c\u6865\u63a5\u961f\u5217\uff0c\u5e76\u63a5\u53d7\u666e\u5409\u534e<sup>&reg;<\/sup>\u8d77\u59cb\u5242\u91cf\u4e3a400 mg\uff08\u6bcf\u65e5\u4e00\u6b21\uff09\u7684\u6cbb\u7597\u3002\u80bf\u7624\u7f13\u89e3\u901a\u8fc7\u76f2\u6001\u72ec\u7acb\u4e2d\u5fc3\u8bc4\u5ba1\uff08BICR\uff09\u91c7\u7528\u300a\u5b9e\u4f53\u80bf\u7624\u53cd\u5e94\u8bc4\u4f30\u6807\u51c6\u300b\uff08RECIST\uff091.1\u7248\u8fdb\u884c\u8bc4\u4f30\u3002<\/p>\n<p><b>\u6709\u6548\u6027\uff1a\u666e\u5409\u534e<\/b><b><sup>&reg;<\/sup><\/b><b>\u5728\u9700\u8981\u7cfb\u7edf\u6027\u6cbb\u7597\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027<\/b><b>RET\u7a81\u53d8MTC\u4e2d\u56fd\u60a3\u8005\u4e2d\u53d6\u5f97\u4e86\u4f18\u8d8a\u548c\u6301\u4e45\u7684\u6297\u80bf\u7624\u6d3b\u6027<\/b><\/p>\n<ul type=\"disc\">\n<li>26\u4f8bRET\u7a81\u53d8\u60a3\u8005\u4e2d\u786e\u8ba4\u7684ORR \u4e3a73.1%, \u5305\u62ec3\u4f8b\u5b8c\u5168\u7f13\u89e3\u548c16\u4f8b\u90e8\u5206\u7f13\u89e3\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u4e3a84.6%\u3002 <\/li>\n<ul type=\"circle\">\n<li>\u65e0\u8bbaRET\u7a81\u53d8\u57fa\u56e0\u578b\u5982\u4f55\uff0c\u5747\u6709\u7f13\u89e3\u3002 <\/li>\n<li>19\u4f8b\u786e\u8ba4\u7f13\u89e3\u7684\u60a3\u8005\u4e2d\uff0c\u4e2d\u4f4dDOR\u672a\u8fbe\u5230\uff0c9\u4e2a\u6708\u7684DOR\u7387\u4e3a100%\u3002 <\/li>\n<li>\u964d\u9499\u7d20\u548c\u764c\u80da\u6297\u539f\uff08CEA\uff09\u6c34\u5e73\u5747\u6709\u5927\u5e45\u964d\u4f4e\u3002<\/li>\n<\/ul>\n<\/ul>\n<p><b>\u5b89\u5168\u6027\uff1a\u666e\u5409\u534e<\/b><b><sup>&reg;<\/sup><\/b><b>\u8010\u53d7\u6027\u826f\u597d\uff0c\u5b89\u5168\u6027\u53ef\u63a7<\/b><\/p>\n<ul type=\"disc\">\n<li>\u666e\u5409\u534e<sup>&reg;<\/sup>\u8010\u53d7\u826f\u597d\uff0c\u5728\u4e2d\u56fd\u60a3\u8005\u4e2d\u6574\u4f53\u5b89\u5168\u53ef\u63a7\uff0c\u4e14\u6ca1\u6709\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u4fe1\u53f7\u3002<\/li>\n<\/ul>\n<p><b>ARROW\u7814\u7a76\u4e3b\u8981\u7814\u7a76\u8005\u3001\u5929\u6d25\u5e02\u4eba\u6c11\u533b\u9662\u9662\u957f\u9ad8\u660e\u6559\u6388<\/b>\u8868\u793a\uff1a\u201c\u8fd1\u5e74\u6765\uff0c\u7532\u72b6\u817a\u764c\u53d1\u75c5\u7387\u6301\u7eed\u4e0a\u5347\u3002\u4e34\u5e8a\u4e0a\u9488\u5bf9RET\u7a81\u53d8MTC\u60a3\u8005\u6cbb\u7597\u624b\u6bb5\u6709\u9650\uff0c\u4e9f\u5f85\u7cbe\u51c6\u9776\u5411\u6cbb\u7597\u65b9\u6848\u3002\u672c\u6b21\u5927\u4f1a\u516c\u5e03\u7684ARROW\u5173\u952e\u6027\u8bd5\u9a8c\u6570\u636e\u663e\u793a\u666e\u5409\u534e<sup>&reg;<\/sup>\u5177\u6709\u4f18\u8d8a\u548c\u6301\u4e45\u7684\u6297\u80bf\u7624\u6d3b\u6027\u4ee5\u53ca\u826f\u597d\u7684\u5b89\u5168\u6027\u3002\u6b64\u6b21\u6570\u636e\u7ed3\u679c\u4e3aRET\u7a81\u53d8\u578b\u665a\u671f\u7532\u72b6\u817a\u764c\u60a3\u8005\u5e26\u6765\u4e86\u65b0\u7684\u5e0c\u671b\u3002\u201d<\/p>\n<p><b>\u57fa\u77f3\u836f\u4e1a\u9996\u5e2d\u533b\u5b66\u5b98\u6768\u5efa\u65b0\u535a\u58eb<\/b>\u8868\u793a\uff1a\u201c\u6211\u4eec\u5f88\u9ad8\u5174\u770b\u5230\u666e\u5409\u534e<sup>&reg;<\/sup>\u9488\u5bf9RET\u7a81\u53d8\u7684\u4e2d\u56fdMTC\u60a3\u8005\u53d6\u5f97\u4e86\u4f18\u5f02\u7684\u7597\u6548\uff0c\u5e76\u4e14\u5b89\u5168\u6027\u826f\u597d\u3002\u76ee\u524d\u666e\u5409\u534e<sup>&reg;<\/sup>\u9488\u5bf9\u8be5\u4eba\u7fa4\u548cRET\u878d\u5408\u9633\u6027\u7532\u72b6\u817a\u764c\u7684\u9002\u5e94\u75c7\u7533\u8bf7\u5728NMPA\u5ba1\u8bc4\u4e2d\uff0c\u5e76\u5148\u540e\u88abNMPA\u6388\u4e88\u7a81\u7834\u6027\u7597\u6cd5\u4ee5\u53ca\u7eb3\u5165\u4e86\u4f18\u5148\u5ba1\u8bc4\u3002\u6211\u4eec\u671f\u5f85\u666e\u5409\u534e<sup>&reg;<\/sup>\u53ef\u4ee5\u65e9\u65e5\u60e0\u53ca\u4e2d\u56fd RET\u7a81\u53d8\u7532\u72b6\u817a\u764c\u60a3\u8005\u3002\u201d<\/p>\n<p>\u666e\u5409\u534e<sup>&reg;<\/sup>\u662f\u9996\u4e2a\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\u7684\u9009\u62e9\u6027RET\u6291\u5236\u5242\uff0c\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u542b\u94c2\u5316\u7597\u7684RET\u57fa\u56e0\u878d\u5408\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027NSCLC\u6210\u4eba\u60a3\u8005\uff0c\u7531\u57fa\u77f3\u836f\u4e1a\u5408\u4f5c\u4f19\u4f34Blueprint Medicines\u516c\u53f8\u5f00\u53d1\u3002\u57fa\u77f3\u836f\u4e1a\u4e0eBlueprint Medicines\u516c\u53f8\u8fbe\u6210\u4e86\u72ec\u5bb6\u5408\u4f5c\u548c\u8bb8\u53ef\u534f\u8bae\uff0c\u83b7\u5f97\u666e\u5409\u534e<sup>&reg;<\/sup>\u5728\u5927\u4e2d\u534e\u5730\u533a\uff0c\u5305\u62ec\u4e2d\u56fd\u5927\u9646\u3001\u9999\u6e2f\u3001\u6fb3\u95e8\u548c\u53f0\u6e7e\u5730\u533a\u7684\u72ec\u5bb6\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6743\u5229\u3002<\/p>\n<p><b>\u5173\u4e8e<\/b><b>ARROW\u7814\u7a76<\/b><\/p>\n<p>ARROW\u7814\u7a76\u662f\u4e00\u9879\u65e8\u5728\u8bc4\u4f30\u666e\u5409\u534e<sup>&reg;<\/sup>\u5728RET\u878d\u5408\u9633\u6027NSCLC\u3001RET\u7a81\u53d8\u578b\u7532\u72b6\u817a\u9ad3\u6837\u764c\u548c\u5176\u4ed6RET\u878d\u5408\u7684\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u6709\u6548\u6027\u7684\u5168\u7403\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n<p>2021\u5e748\u6708\uff0c\u300a\u67f3\u53f6\u5200&middot;\u7cd6\u5c3f\u75c5\u4e0e\u5185\u5206\u6ccc\u5b66\u300b\u53d1\u8868\u4e86ARROW\u7814\u7a76\u4e2dRET\u7a81\u53d8MTC\u5168\u7403\u60a3\u8005\u6570\u636e\u3002\u622a\u81f32020\u5e745\u670822\u65e5\u6570\u636e\u622a\u6b62\u65e5\u671f\uff0c\u666e\u5409\u534e<sup>&reg;<\/sup>\u5728RET\u7a81\u53d8\u7684\u7532\u72b6\u817a\u764c\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u5f3a\u6548\u800c\u6301\u4e45\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u6240\u6709\u60a3\u8005\u63a5\u53d7\u7684\u8d77\u59cb\u5242\u91cf\u4e3a400\u6beb\u514b\u6bcf\u65e5\u4e00\u6b21\u3002\u572855\u540d\u65e2\u5f80\u63a5\u53d7\u8fc7\u5361\u535a\u66ff\u5c3c\u6216\u51e1\u5fb7\u4ed6\u5c3c\u6cbb\u7597\u7684RET\u7a81\u53d8MTC\u60a3\u8005\u4e2d\uff0cORR\u4e3a60%\uff0895%CI\uff1a46%\uff0c73%\uff09\uff0c\u4e2d\u4f4dDOR\u5c1a\u672a\u8fbe\u5230\uff0895%CI\uff1a15.1\u4e2a\u6708\uff0c\u4e0d\u53ef\u8bc4\u4f30\uff09\u3002\u572821\u540d\u672a\u7ecf\u7cfb\u7edf\u6027\u6cbb\u7597\u7684RET\u7a81\u53d8MTC\u60a3\u8005\u4e2d\uff0cORR\u4e3a71%\uff0895%CI\uff1a48%\uff0c89%\uff09\uff0c\u4e2d\u4f4dDOR\u5c1a\u672a\u8fbe\u5230\uff0895%CI\uff1a\u4e0d\u53ef\u8bc4\u4f30\uff0c\u4e0d\u53ef\u8bc4\u4f30\uff09\u3002\u57289\u540dRET\u878d\u5408\u9633\u6027\u7532\u72b6\u817a\u764c\u60a3\u8005\u4e2d\uff0cORR\u4e3a89%\uff0895%CI\uff1a52%\uff0c100%\uff09\uff0c\u4e2d\u4f4dDOR\u5c1a\u672a\u8fbe\u5230\uff0895%CI\uff1a\u4e0d\u53ef\u8bc4\u4f30\uff0c\u4e0d\u53ef\u8bc4\u4f30\uff09\u3002\u5728142\u540dRET\u7a81\u53d8\u7532\u72b6\u817a\u764c\u60a3\u8005\u4e2d\uff0c\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u4e8b\u4ef6\u662f\u8d2b\u8840\u3001\u808c\u8089\u9aa8\u9abc\u75bc\u75db\u3001\u4fbf\u79d8\u3001\u5929\u95e8\u51ac\u6c28\u9178\u8f6c\u6c28\u9176\u5347\u9ad8\u548c\u9ad8\u8840\u538b\u3002<\/p>\n<p><b>\u5173\u4e8e\u7532\u72b6\u817a\u764c<\/b><\/p>\n<p><span id=\"spanHghlt1c76\">\u7532\u72b6\u817a\u764c\u662f\u6700\u5e38\u89c1\u7684\u5185\u5206\u6ccc\u6076\u6027\u80bf\u7624<\/span>\uff0c\u8fd1\u51e0\u5e74\u53d1\u75c5\u7387\u663e\u8457\u4e0a\u5347\u3002\u6839\u636e\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u56fd\u9645\u764c\u75c7\u7814\u7a76\u673a\u6784\uff08IARC\uff09\u53d1\u5e03\u76842020\u5e74\u5168\u7403\u6700\u65b0\u764c\u75c7\u8d1f\u62c5\u6570\u636e\uff0c\u4e2d\u56fd\u57282020\u5e74\u7ea6\u670922\u4e07\u65b0\u53d1\u7532\u72b6\u817a\u764c\u75c5\u4f8b\u6570\uff0c\u5176\u4e2d\u5973\u6027\u65b0\u53d1\u75c5\u4f8b\u6570\u7ea6\u4e3a17\u4e07[1]\u3002\u7532\u72b6\u817a\u764c\u53d1\u75c5\u7387\u4f4d\u5c45\u6211\u56fd\u57ce\u5e02\u5730\u533a\u5973\u6027\u6240\u6709\u6076\u6027\u80bf\u7624\u7684\u7b2c4\u4f4d\u3002<\/p>\n<p>\u7532\u72b6\u817a\u764c\u5728\u4e34\u5e8a\u4e0a\u5206\u4e3a\u4e73\u5934\u72b6\u764c\u3001\u6ee4\u6ce1\u764c\u3001\u672a\u5206\u5316\u764c\u548c\u9ad3\u6837\u764c\u7b49\u591a\u4e2a\u4e9a\u578b\uff0c\u4e0d\u540c\u7c7b\u578b\u7684\u7532\u72b6\u817a\u764c\u6839\u636e\u5176\u80bf\u7624\u7279\u70b9\uff0c\u6cbb\u7597\u624b\u6bb5\u53ca\u9884\u540e\u5747\u4e0d\u76f8\u540c\u3002<\/p>\n<p>RET\u878d\u5408\u548c\u6fc0\u6d3b\u7a81\u53d8\u662f\u8bb8\u591a\u764c\u75c7\u7c7b\u578b\uff08\u5305\u62ecNSCLC\u548c\u591a\u79cd\u7c7b\u578b\u7684\u7532\u72b6\u817a\u764c\uff09\u4e2d\u7684\u5173\u952e\u75be\u75c5\u9a71\u52a8\u56e0\u7d20\u3002\u5927\u7ea610-20%\u7684\u7532\u72b6\u817a\u4e73\u5934\u72b6\u764c\uff08\u6700\u5e38\u89c1\u7684\u7532\u72b6\u817a\u764c\uff09\u60a3\u8005\u643a\u5e26RET\u878d\u5408\uff0c\u5927\u7ea690%\u7684\u665a\u671f\u7532\u72b6\u817a\u9ad3\u6837\u764c\uff08\u7ea6\u5360\u7532\u72b6\u817a\u764c\u76842-5%\uff09\u60a3\u8005\u643a\u5e26RET\u7a81\u53d8\u3002\u4e2d\u56fdRET\u7a81\u53d8\u578bMTC\u60a3\u8005\u76ee\u524d\u5c1a\u65e0\u6709\u6548\u7684\u83b7\u6279\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n<p><b>\u5173\u4e8e\u666e\u5409\u534e<\/b><b><sup>&reg;<\/sup><\/b><b>\uff08\u666e\u62c9\u66ff\u5c3c\u80f6\u56ca\uff09<\/b><\/p>\n<p>\u666e\u5409\u534e<sup>&reg;<\/sup>\u662f\u4e00\u79cd\u53e3\u670d\u3001\u6bcf\u65e5\u4e00\u6b21\u3001\u5f3a\u6548\u9ad8\u9009\u62e9\u6027RET\u6291\u5236\u5242\uff0c\u5df2\u83b7\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u542b\u94c2\u5316\u7597\u7684\u8f6c\u67d3\u91cd\u6392\uff08RET\uff09\u57fa\u56e0\u878d\u5408\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u6210\u4eba\u60a3\u8005\u3002<\/p>\n<p>\u666e\u5409\u534e<sup>&reg;<\/sup>\u9488\u5bf9\u9700\u8981\u7cfb\u7edf\u6027\u6cbb\u7597\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027RET\u7a81\u53d8\u7532\u72b6\u817a\u9ad3\u6837\u764c (MTC)\uff0c\u4ee5\u53ca\u9700\u8981\u7cfb\u7edf\u6027\u6cbb\u7597\u4e14\u653e\u5c04\u6027\u7898\u96be\u6cbb\uff08\u5982\u653e\u5c04\u6027\u7898\u9002\u7528\uff09\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027RET\u878d\u5408\u9633\u6027\u7532\u72b6\u817a\u764c\u7684\u65b0\u9002\u5e94\u75c7\u7533\u8bf7\u4e5f\u5df2\u7ecf\u4e8e2021\u5e744\u6708\u83b7\u5f97NMPA\u53d7\u7406\u5e76\u88ab\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u3002<\/p>\n<p>\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u5176\u4ee5\u5546\u54c1\u540d\u4e3aGAVRETO&#x2122;\u4e0a\u5e02\u9500\u552e\uff0c\u4e09\u9879\u9002\u5e94\u75c7\u5206\u522b\u4e3a\uff1a\u7528\u4e8e\u6cbb\u7597\u7ecfFDA\u6279\u51c6\u7684\u68c0\u6d4b\u65b9\u6cd5\u68c0\u6d4b\u8bc1\u5b9e\u4e3a\u8f6c\u79fb\u6027RET\u878d\u5408\u9633\u6027NSCLC\u7684\u6210\u4eba\u60a3\u8005\u3001\u9700\u8981\u7cfb\u7edf\u6027\u6cbb\u7597\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027RET\u7a81\u53d8\u7532\u72b6\u817a\u9ad3\u6837\u764c\u6210\u4eba\u548c12\u5c81\u53ca\u4ee5\u4e0a\u513f\u7ae5\u60a3\u8005\uff0c\u4ee5\u53ca\u9700\u8981\u7cfb\u7edf\u6027\u6cbb\u7597\u4e14\u653e\u5c04\u6027\u7898\u96be\u6cbb\uff08\u5982\u9002\u7528\uff09\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027RET\u878d\u5408\u9633\u6027\u7532\u72b6\u817a\u764c\u6210\u4eba\u548c12\u5c81\u53ca\u4ee5\u4e0a\u513f\u7ae5\u60a3\u8005\u3002\u8fd9\u4e9b\u9002\u5e94\u75c7\u57fa\u4e8eORR \u548c DOR \u6570\u636e\u5728\u52a0\u901f\u5ba1\u6279\u9014\u5f84\u4e0b\u83b7\u5f97\u6279\u51c6\u3002\u9488\u5bf9\u8fd9\u4e9b\u9002\u5e94\u75c7\u7684\u6301\u7eed\u6279\u51c6\u53ef\u80fd\u53d6\u51b3\u4e8e\u786e\u8bc1\u6027\u8bd5\u9a8c\u4e2d\u4e34\u5e8a\u83b7\u76ca\u7684\u9a8c\u8bc1\u548c\u63cf\u8ff0\u3002<\/p>\n<p>\u666e\u5409\u534e<sup>&reg;<\/sup>\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u8fd8\u672a\u83b7\u6279\u7528\u4e8e\u5176\u4ed6\u9002\u5e94\u75c7\u3002<\/p>\n<p>\u666e\u5409\u534e<sup>&reg;<\/sup>\u65e8\u5728\u9009\u62e9\u6027\u5730\u548c\u6709\u6548\u5730\u9776\u5411\u81f4\u764c\u6027RET\u7a81\u53d8\uff0c\u5305\u62ec\u53ef\u80fd\u5bfc\u81f4\u6cbb\u7597\u8010\u836f\u7684\u7ee7\u53d1\u6027RET\u7a81\u53d8\u3002\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u666e\u5409\u534e<sup>&reg;<\/sup>\u6291\u5236RET\u7684\u6d53\u5ea6\u4f4e\u4e8e\u5176\u4ed6\u836f\u7269\u76f8\u5173\u6fc0\u9176\uff0c\u5305\u62ecVEGFR2\u3001FGFR2\u548cJAK2\u3002<\/p>\n<p>\u5168\u7403\u8303\u56f4\u5185\uff0c\u9488\u5bf9\u666e\u5409\u534e<sup>&reg;<\/sup>\u7528\u4e8e\u6cbb\u7597RET\u878d\u5408\u9633\u6027\u7684NSCLC\u3001\u5404\u7c7b\u7532\u72b6\u817a\u764c\u4ee5\u53ca\u5176\u4ed6\u5b9e\u4f53\u7624\u60a3\u8005\u7684\u4e34\u5e8a\u5f00\u53d1\u6b63\u5728\u8fdb\u884c\u30022021\u5e749\u6708\uff0c\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\u4eba\u7528\u836f\u54c1\u59d4\u5458\u4f1a\u5efa\u8bae\u6279\u51c6\u666e\u5409\u534e<sup>&reg;<\/sup>\u7684\u4e0a\u5e02\u8bb8\u53ef\u7533\u8bf7\uff0c\u7528\u4e8e\u6cbb\u7597RET\u878d\u5408\u9633\u6027NSCLC\u3002FDA\u6388\u4e88\u666e\u5409\u534e<sup>&reg;<\/sup>\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff0c\u7528\u4e8e\u6cbb\u7597\u94c2\u7c7b\u5316\u7597\u540e\u8fdb\u5c55\u7684RET\u878d\u5408\u9633\u6027NSCLC\uff0c\u4ee5\u53ca\u9700\u8981\u5168\u8eab\u6cbb\u7597\u4e14\u5c1a\u65e0\u66ff\u4ee3\u7597\u6cd5\u7684RET\u7a81\u53d8\u9633\u6027\u7532\u72b6\u817a\u9ad3\u6837\u764c\u3002<\/p>\n<p><b>\u5173\u4e8e\u57fa\u77f3\u836f\u4e1a<\/b><\/p>\n<p>\u57fa\u77f3\u836f\u4e1a\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801: 2616\uff09\u662f\u4e00\u5bb6\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u7814\u7a76\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u521b\u65b0\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u53ca\u7cbe\u51c6\u6cbb\u7597\u836f\u7269\uff0c\u4ee5\u6ee1\u8db3\u4e2d\u56fd\u548c\u5168\u7403\u764c\u75c7\u60a3\u8005\u7684\u6bb7\u5207\u533b\u7597\u9700\u6c42\u3002\u6210\u7acb\u4e8e2015\u5e74\u5e95\uff0c\u57fa\u77f3\u836f\u4e1a\u5df2\u96c6\u7ed3\u4e86\u4e00\u652f\u5728\u65b0\u836f\u7814\u53d1\u3001\u4e34\u5e8a\u7814\u7a76\u4ee5\u53ca\u5546\u4e1a\u8fd0\u8425\u65b9\u9762\u62e5\u6709\u4e30\u5bcc\u7ecf\u9a8c\u7684\u4e16\u754c\u7ea7\u7ba1\u7406\u56e2\u961f\u3002\u516c\u53f8\u4ee5\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u8054\u5408\u7597\u6cd5\u4e3a\u6838\u5fc3\uff0c\u5efa\u7acb\u4e86\u4e00\u676115\u79cd\u80bf\u7624\u5019\u9009\u836f\u7269\u7ec4\u6210\u7684\u4e30\u5bcc\u4ea7\u54c1\u7ba1\u7ebf\u3002\u76ee\u524d\uff0c\u57fa\u77f3\u836f\u4e1a\u5728\u5168\u7403\u8303\u56f4\u5185\u5df2\u7ecf\u83b7\u5f97\u4e86\u4e09\u4e2a\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u7684\u6279\u51c6\uff0c\u5206\u522b\u5728\u4e2d\u56fd\u5927\u9646\u83b7\u5f97\u4e24\u4e2a\u65b0\u836f\u4e0a\u5e02\u6279\u51c6\u3001\u5728\u53f0\u6e7e\u5730\u533a\u83b7\u5f97\u4e00\u4e2a\u65b0\u836f\u4e0a\u5e02\u6279\u51c6\u3002\u591a\u6b3e\u540e\u671f\u5019\u9009\u836f\u7269\u6b63\u5904\u4e8e\u5173\u952e\u6027\u4e34\u5e8a\u8bd5\u9a8c\u6216\u6ce8\u518c\u9636\u6bb5\u3002\u57fa\u77f3\u836f\u4e1a\u7684\u613f\u666f\u662f\u6210\u4e3a\u4eab\u8a89\u5168\u7403\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u5f15\u9886\u653b\u514b\u764c\u75c7\u4e4b\u8def\u3002<\/p>\n<p>\u5982\u9700\u4e86\u89e3\u6709\u5173\u57fa\u77f3\u836f\u4e1a\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee\uff1a<a target=\"_blank\" href=\"http:\/\/www.cstonepharma.com\/\" rel=\"nofollow noopener\">www.cstonepharma.com<\/a>\u3002<\/p>\n<p><b>\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n<p>\u672c\u6587\u6240\u4f5c\u51fa\u7684\u524d\u77bb\u6027\u9648\u8ff0\u4ec5\u4e0e\u672c\u6587\u4f5c\u51fa\u8be5\u9648\u8ff0\u5f53\u65e5\u7684\u4e8b\u4ef6\u6216\u8d44\u6599\u6709\u5173\u3002\u9664\u6cd5\u5f8b\u89c4\u5b9a\u5916\uff0c\u4e8e\u4f5c\u51fa\u524d\u77bb\u6027\u9648\u8ff0\u5f53\u65e5\u4e4b\u540e\uff0c\u65e0\u8bba\u662f\u5426\u51fa\u73b0\u65b0\u8d44\u6599\u3001\u672a\u6765\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u51b5\uff0c\u6211\u4eec\u5e76\u65e0\u8d23\u4efb\u66f4\u65b0\u6216\u516c\u5f00\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9648\u8ff0\u53ca\u9884\u6599\u4e4b\u5916\u7684\u4e8b\u4ef6\u3002\u8bf7\u7ec6\u9605\u672c\u6587\uff0c\u5e76\u7406\u89e3\u6211\u4eec\u7684\u5b9e\u9645\u672a\u6765\u4e1a\u7ee9\u6216\u8868\u73b0\u53ef\u80fd\u4e0e\u9884\u671f\u6709\u91cd\u5927\u5dee\u5f02\u3002\u672c\u6587\u5185\u6240\u6709\u9648\u8ff0\u4e43\u672c\u6587\u7ae0\u520a\u53d1\u65e5\u671f\u4f5c\u51fa\uff0c\u53ef\u80fd\u56e0\u672a\u6765\u53d1\u5c55\u800c\u51fa\u73b0\u53d8\u52a8\u3002<\/p>\n<p><b>\u5546\u6807<\/b><\/p>\n<p>Blueprint Medicines, GAVRETO\u53ca\u5176\u76f8\u5173\u5546\u6807\u4e3aBlueprint Medicines Corporation\u6240\u6709\u3002<\/p>\n<\/p>\n<hr \/>\n<\/p>\n[1] <a target=\"_blank\" href=\"https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/160-china-fact-sheets.pdf\" rel=\"nofollow noopener\">https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/160-china-fact-sheets.pdf<\/a><\/p>\n<p>\u76f8\u5173\u94fe\u63a5 :<\/p>\n<p>http:\/\/www.cstonepharma.com<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e3b\u8981\u7597\u6548\u6570\u636e\u663e\u793a\uff1a\u666e\u5409\u534e&reg;\u5728\u665a\u671f\u6216\u8f6c\u79fb\u6027\u8f6c\u67d3\u91cd\u6392\uff08RET\uff09\u7a81\u53d8\u7532\u72b6\u817a\u9ad3\u6837\u764c(MTC)\u4e2d\u56fd\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u4e86\u4f18\u8d8a\u548c\u6301\u4e45\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u786e\u8ba4\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u8fbe\u523073.1%\uff0c9\u4e2a\u6708\u7684\u7f13\u89e3\u6301\u7eed\u7387(DOR)\u4e3a100% 2021\u5e744\u6708\uff0c\u666e\u5409\u534e&reg;\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u6216\u8f6c\u79fb\u6027RET\u7a81\u53d8MTC\u548c\u665a\u671f\u6216\u8f6c\u79fb\u6027RET\u878d\u5408\u9633\u6027\u7532\u72b6\u817a\u764c\u60a3\u8005\u7684\u9002\u5e94\u75c7\u5df2\u7ecf\u83b7\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40(NMPA)\u53d7\u7406\u5e76\u88ab\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4 \u4e2d\u56fd\u82cf\u5dde2021\u5e7410\u67082\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u57fa\u77f3\u836f\u4e1a (\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a2616) \uff0c\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u7814\u7a76\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u521b\u65b0\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u53ca\u7cbe\u51c6\u6cbb\u7597\u836f\u7269\u7684\u9886\u5148\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\uff0c\u57282021\u5e74\u7b2c 90 \u5c4a\u7f8e\u56fd\u7532\u72b6\u817a\u534f\u4f1a\u5e74\u5ea6\u4f1a\u8bae(The 90th Annual Meeting of the American Thyroid Association 2021) \u4e0a\uff0c\u9009\u62e9\u6027RET\u6291\u5236\u5242\u666e\u5409\u534e&reg;\uff08\u666e\u62c9\u66ff\u5c3c\u80f6\u56ca\uff09\u5728\u5168\u7403I\/II\u671fARROW\u8bd5\u9a8c\u4e2d\u6cbb\u7597\u665a\u671f\u6216\u8f6c\u79fb\u6027RET\u7a81\u53d8MTC\u4e2d\u56fd\u60a3\u8005\u7684\u6ce8\u518c\u7814\u7a76\u6570\u636e\u4ee5\u91cd\u78c5\u53e3\u5934\u62a5\u544a(Late Breaking Oral )\u5f62\u5f0f\u516c\u5e03\u4e86\u8be6\u7ec6\u6570\u636e\u3002\u7814\u7a76\u6570\u636e\u663e\u793a\uff0c\u666e\u5409\u534e&reg;\u5728\u9700\u8981\u7cfb\u7edf\u6027\u6cbb\u7597\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027RET\u7a81\u53d8MTC\u4e2d\u56fd\u60a3\u8005\u4e2d\uff0c\u663e\u793a\u51fa\u4e86\u5e7f\u6cdb\u548c\u6301\u4e45\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u4e0e\u4ee5\u5f80\u62a5\u9053\u7684ARROW\u5168\u7403\u4eba\u7fa4\u4e00\u81f4\u3002\u6574\u4f53\u5b89\u5168\u53ef\u63a7\uff0c\u4e14\u6ca1\u6709\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u4fe1\u53f7\u3002 \u7814\u7a76\u9886\u57df\uff1a\u7532\u72b6\u817a\u764c \u65e5\u671f\uff1a2021\u5e7410\u67082\u65e500:00-1:00 (\u5317\u4eac\u65f6\u95f4) \u62a5\u544a\u5f62\u5f0f\uff1a\u4e34\u5e8a\u53e3\u5934\u62a5\u544a\u6458\u8981\u73af\u8282 \u9898\u76ee\uff1a\u9009\u62e9\u6027RET\u6291\u5236\u5242\u666e\u62c9\u66ff\u5c3c\u6cbb\u7597\u665a\u671fRET\u7a81\u53d8MTC\u7684\u7597\u6548\u548c\u5b89\u5168\u6027 \u62a5\u544a\u7f16\u53f7\uff1a&nbsp;Late Breaking Oral 3 \u4e3b\u8981\u7814\u7a76\u8005\uff1a\u5929\u6d25\u5e02\u4eba\u6c11\u533b\u9662\u9662\u957f \u9ad8\u660e \u6559\u6388 \u62a5\u544a\u4eba\uff1a\u5929\u6d25\u533b\u79d1\u5927\u5b66\u80bf\u7624\u533b\u9662 \u90d1\u5411\u524d \u6559\u6388 \u622a\u81f3\u6570\u636e\u622a\u6b62\u65e5\u671f\uff082021\u5e744\u670812\u65e5\uff09\uff0c\u5171\u6709\u6765\u81ea\u4e2d\u56fd\u7814\u7a76\u4e2d\u5fc3\u768428\u4f8bRET\u7a81\u53d8\u9633\u6027MTC\u60a3\u8005\u7eb3\u5165\u4e86\u5168\u7403ARROW\u7814\u7a76\u4e2d\u56fdMTC\u6ce8\u518c\u6865\u63a5\u961f\u5217\uff0c\u5e76\u63a5\u53d7\u666e\u5409\u534e&reg;\u8d77\u59cb\u5242\u91cf\u4e3a400 mg\uff08\u6bcf\u65e5\u4e00\u6b21\uff09\u7684\u6cbb\u7597\u3002\u80bf\u7624\u7f13\u89e3\u901a\u8fc7\u76f2\u6001\u72ec\u7acb\u4e2d\u5fc3\u8bc4\u5ba1\uff08BICR\uff09\u91c7\u7528\u300a\u5b9e\u4f53\u80bf\u7624\u53cd\u5e94\u8bc4\u4f30\u6807\u51c6\u300b\uff08RECIST\uff091.1\u7248\u8fdb\u884c\u8bc4\u4f30\u3002 \u6709\u6548\u6027\uff1a\u666e\u5409\u534e&reg;\u5728\u9700\u8981\u7cfb\u7edf\u6027\u6cbb\u7597\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027RET\u7a81\u53d8MTC\u4e2d\u56fd\u60a3\u8005\u4e2d\u53d6\u5f97\u4e86\u4f18\u8d8a\u548c\u6301\u4e45\u7684\u6297\u80bf\u7624\u6d3b\u6027 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