{"id":46504,"date":"2021-09-29T19:15:00","date_gmt":"2021-09-29T12:15:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021092919150046504"},"modified":"2021-09-30T17:55:06","modified_gmt":"2021-09-30T09:55:06","slug":"%e7%9a%93%e9%98%b3%e7%94%9f%e7%89%a9%e4%b8%8e%e7%8f%b2%e8%be%be%e7%94%9f%e7%89%a9%e8%be%be%e6%88%90%e6%8a%97%e4%bd%93%e5%81%b6%e8%81%94%e8%8d%af%e7%89%a9%ef%bc%88adcs%ef%bc%89%e6%88%98%e7%95%a5","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021092919150046504","title":{"rendered":"\u7693\u9633\u751f\u7269\u4e0e\u73f2\u8fbe\u751f\u7269\u8fbe\u6210\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADCs\uff09\u6218\u7565\u5408\u4f5c"},"content":{"rendered":"<p><p>\u676d\u5dde2021\u5e749\u670829\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u56fd\u5185\u9886\u5148\u4e00\u7ad9\u5f0f\u751f\u7269\u836fCDMO\u5e73\u53f0\u676d\u5dde\u7693\u9633\u751f\u7269\u6280\u672f\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0\u201c<b>\u7693\u9633\u751f\u7269<\/b>\u201d\uff09\u4e0e\u4e13\u6ce8\u4e8e\u5fae\u751f\u7269\u53d1\u9175\u7814\u7a76\u4e0e\u5f00\u53d1\u5353\u8d8a\u670d\u52a1\u5e73\u53f0\u6d59\u6c5f\u73f2\u8fbe\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0\u201c<b>\u73f2\u8fbe\u751f\u7269<\/b>\u201d\uff09\u53cc\u65b9\u5171\u540c\u5ba3\u5e03\uff0c\u5c06\u5f00\u5c55\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADCs\uff09\u4e13\u4e1a\u9886\u57dfCDMO\u670d\u52a1\u6218\u7565\u5408\u4f5c\uff0c\u4e3a\u56fd\u5185\u521b\u65b0\u6297\u4f53\u5076\u8054\u836f\u7269\u7814\u53d1\u4f01\u4e1a\u63d0\u4f9b\u65b0\u7684\u5408\u4f5c\u89e3\u51b3\u65b9\u6848\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder1\">\n<p> <a href=\"https:\/\/mma.prnasia.com\/media2\/1638533\/image1.html\" target=\"_blank\" rel=\"nofollow noopener\"> <img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/image1-835.jpg\" title=\"\" alt=\"\" \/> <\/a> <br \/><span><\/span><\/p>\n<\/p><\/div>\n<p>\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADCs\uff09\u7531\u5355\u514b\u9686\u6297\u4f53(mAb)\u3001\u8fde\u63a5\u5b50(linker)\u548c\u7ec6\u80de\u6bd2\u6027\u5c0f\u5206\u5b50(cytotoxin\/payload)\u4e09\u90e8\u5206\u7ec4\u6210\uff0c\u901a\u8fc7\u5355\u514b\u9686\u6297\u4f53\u4e0e\u80bf\u7624\u7ec6\u80de\u8868\u9762\u7684\u7279\u5f02\u6027\u6297\u539f\u7ed3\u5408\uff0c\u5c06\u7ec6\u80de\u6bd2\u836f\u7269\u5b9a\u5411\u9012\u9001\u5230\u80bf\u7624\u75c5\u7076\u3002\u5bf9\u6bd4\u4f20\u7edf\u7684\u5316\u836f\u548c\u751f\u7269\u836f\uff0c\u660e\u663e\u63d0\u5347\u4e86\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002ADC\u9886\u57df\u5728\u8fd110\u5e74\u6765\u53d6\u5f97\u4e86\u5feb\u901f\u7684\u53d1\u5c55\uff0c\u6cbb\u7597\u7a97\u53e3\u4e0d\u65ad\u6269\u5927\uff0c\u6839\u636eEvaluate Pharma\u548cBCG\u7684\u9884\u6d4b\uff0c\u5168\u7403ADC\u5e02\u573a\u9884\u8ba12024\u5e74\u5c06\u8fbe\u5230129\u4ebf\u7f8e\u5143\uff0c2018\u81f32024\u5e74\u7684\u5e74\u590d\u5408\u589e\u957f\u7387\u7ea6\u4e3a35%\u3002<\/p>\n<p>\u4eca\u5e74\u56fd\u5185\u4f01\u4e1a\u5728ADC\u65b9\u9762\u52a8\u6001\u8fdb\u5c55\uff0c\u8363\u660c\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u7684ADC\u65b0\u836fRC48(disitamab vedotin\uff0c\u5546\u54c1\u540d\uff1a\u7231\u5730\u5e0c\uff09\u5df2\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u5ba1\u6279\uff0c\u5e76\u83b7\u51c6\u5728\u7f8e\u56fd\u76f4\u63a5\u8fdb\u884c\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u9002\u5e94\u8bc1\u4e3aHER2\u9633\u6027\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u3002)\uff1b\u6d59\u6c5f\u65b0\u7801\u751f\u7269\u7533\u62a5\u7684\u6ce8\u5c04\u7528\u91cd\u7ec4\u4eba\u6e90\u5316\u6297HER2\u5355\u6297-AS269\u5076\u8054\u7269\uff08ARX788\uff09\u62df\u7eb3\u5165\u7a81\u7834\u6027\u6cbb\u7597\u54c1\u79cd\uff0c\u62df\u5b9a\u9002\u5e94\u75c7\u4e3a\uff1aHER2\u9633\u6027\u665a\u671f\u4e73\u817a\u764c\u4e8c\u7ebf\u6cbb\u7597\u3002\u53e6\u5916\u6052\u745e\u533b\u836f\u4eca\u5e74\u5f00\u59cb\u5bc6\u96c6\u7533\u62a5\uff0c\u76ee\u524d\u7d2f\u8ba1\u7533\u62a56\u6b3eADC\u65b0\u836f\uff0c\u4e50\u666e\u751f\u7269\u3001\u591a\u79a7\u751f\u7269\u3001\u79d1\u4f26\u836f\u4e1a\u3001\u77f3\u836f\u96c6\u56e2\u3001\u8bd7\u5065\u751f\u7269\u7b49\u5747\u6709\u591a\u6b3eADC\u65b0\u836f\u9646\u7eedIND\u7533\u62a5\u3002\u540c\u65f6ADC\u7684\u7814\u53d1\u70ed\u6f6e\u4e5f\u5438\u5f15\u4e86\u8bb8\u591a\u65b0\u9510\u516c\u53f8\u6295\u8eab\u5176\u4e2d\u3002\u4f8b\u5982\u5b9c\u8054\u751f\u7269\u3001\u666e\u65b9\u751f\u7269\u5728\u4eca\u5e74\u4e0a\u534a\u5e74\u521a\u5b8c\u6210\u4e86A\u8f6e\u878d\u8d44\uff0c\u8bfa\u7075\u751f\u7269\u57286\u670815\u65e5\u83b7\u5f97\u534e\u4e1c\u533b\u836f3500\u4e07\u5143\u7684\u6218\u7565\u6295\u8d44\u5408\u4f5c\u8fdb\u884c\u65b0\u4e00\u4ee3\u6297\u4f53\u5076\u8054\u6280\u672f\u7684\u836f\u7269\u5f00\u53d1\u3002<\/p>\n<p>\u57fa\u4e8e\u76ee\u524d\u56fd\u5185\u826f\u597dADC\u7814\u53d1\u5e02\u573a\u6c1b\u56f4\uff0c\u6839\u636e\u534f\u8bae\u73f2\u8fbe\u751f\u7269\u548c\u7693\u9633\u751f\u7269\u5171\u540c\u4e3a\u5ba2\u6237\u63d0\u4f9bADC\u4ea7\u54c1\u524d\u671f\u5de5\u827a\u5f00\u53d1\u3001\u4e2d\u95f4\u4f53\u89c4\u6a21\u653e\u5927\u548cGMP\u751f\u4ea7\u670d\u52a1\u3002\u57fa\u4e8e\u53cc\u65b9\u8d44\u6e90\u4f18\u52bf\uff0c\u7693\u9633\u751f\u7269\u5c06\u63d0\u4f9bADC\u6240\u9700\u8981\u7684\u88f8\u6297\u53caADC\u5076\u8054\u7684\u5de5\u827a\u5f00\u53d1\uff0c\u5206\u6790\u65b9\u6cd5\u5f00\u53d1\uff0c\u4e2d\u8bd5\u751f\u4ea7\u4e0e\u8d28\u91cf\u63a7\u5236\u3001\u7a33\u5b9a\u6027\u7814\u7a76\u7b49\u5de5\u4f5c\uff0c\u73f2\u8fbe\u751f\u7269\u5c06\u57fa\u4e8e\u81ea\u8eab\u5728\u8fde\u63a5\u5b50\uff0c\u6bd2\u7d20\u751f\u4ea7\u5927\u89c4\u6a21\u751f\u4ea7\u53ca\u5f00\u53d1\u7684\u4f18\u52bf\uff0c\u63d0\u4f9bADC\u6240\u9700\u8981\u7684linker,payload\u3002\u540c\u65f6\u4e24\u5bb6\u516c\u53f8\u5747\u4f4d\u4e8e\u676d\u5dde\u53ef\u4ee5\u5b9e\u73b0\u5408\u4f5c\u5728\u5730\u57df\u4e0a\u65e0\u7f1d\u8854\u63a5\uff0c\u901a\u8fc7\u6574\u5408\u53cc\u65b9\u7684\u6280\u672f\u670d\u52a1\u548c\u8d44\u6e90\u4f18\u52bf\u52a0\u5f3a\u4e92\u8865\u534f\u4f5c\u4ece\u800c\u5b9e\u73b0\u5f3a\u5f3a\u8054\u5408\u3002<\/p>\n<p>\u73f2\u8fbe\u751f\u7269\u603b\u7ecf\u7406\u90d1\u73b2\u8f89\u5148\u751f\uff1a\u201c\u7693\u9633\u751f\u7269\u5728ADC\u9886\u57df\uff0c\u4e00\u76f4\u4e3a\u56fd\u5185\u5ba2\u6237\u63d0\u4f9b\u5c0f\u8bd5\u5de5\u827a\u3001\u6837\u54c1\u5236\u5907CRO\u670d\u52a1\uff0c\u540c\u65f6\u7693\u9633\u751f\u7269\u62e5\u6709ADC\u6240\u9700\u8981\u7684\u88f8\u6297\u751f\u4ea7GMP\u8f66\u95f4\uff0c\u4ee5\u53ca\u8d28\u91cf\u63a7\u5236\u5206\u6790\u5e73\u53f0\uff0c\u53cc\u65b9\u7ed3\u5408\u81ea\u8eab\u7684\u4f18\u52bf\u5728ADC\u5f00\u53d1\u4e0e\u751f\u4ea7\u5f00\u542f\u65b0\u7684\u5408\u4f5c\u7bc7\u7ae0\u3002\u201d<\/p>\n<p>\u7693\u9633\u751f\u7269\u8463\u4e8b\u957f\u674e\u6d69\u5f3a\u5148\u751f\uff1a\u201c\u73f2\u8fbe\u751f\u7269\u5c5e\u4e8e\u534e\u4e1c\u533b\u836f\u63a7\u80a1\u5b50\u516c\u53f8\uff0c\u5728\u5f00\u53d1\u4e0e\u751f\u4ea7ADC\u6240\u9700\u8981\u7684\u8fde\u63a5\u5b50\u3001\u6bd2\u7d20\u65b9\u9762\u6709\u7740\u4e30\u5bcc\u7684\u7ecf\u9a8c\uff0c\u540c\u65f6\u80fd\u591f\u62e5\u6709\u5546\u4e1a\u5316\u751f\u4ea7\u89c4\u6a21\u6548\u5e94\uff0c\u7693\u9633\u751f\u7269\u643a\u624b\u4e0e\u73f2\u8fbe\u751f\u7269\u6218\u7565\u5408\u4f5c\uff0c\u80fd\u591f\u4e3a\u5ba2\u6237\u5728ADC\u5f00\u53d1\u63d0\u4f9b\u66f4\u591a\u7684\u9009\u62e9\u89e3\u51b3\u65b9\u6848\u3002\u201d<\/p>\n<p>\u76f8\u5173\u94fe\u63a5 :<\/p>\n<p>http:\/\/www.hs-biopharm.com<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u676d\u5dde2021\u5e749\u670829\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u56fd\u5185\u9886\u5148\u4e00\u7ad9\u5f0f\u751f\u7269\u836fCDMO\u5e73\u53f0\u676d\u5dde\u7693\u9633\u751f\u7269\u6280\u672f\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0\u201c\u7693\u9633\u751f\u7269\u201d\uff09\u4e0e\u4e13\u6ce8\u4e8e\u5fae\u751f\u7269\u53d1\u9175\u7814\u7a76\u4e0e\u5f00\u53d1\u5353\u8d8a\u670d\u52a1\u5e73\u53f0\u6d59\u6c5f\u73f2\u8fbe\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0\u201c\u73f2\u8fbe\u751f\u7269\u201d\uff09\u53cc\u65b9\u5171\u540c\u5ba3\u5e03\uff0c\u5c06\u5f00\u5c55\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADCs\uff09\u4e13\u4e1a\u9886\u57dfCDMO\u670d\u52a1\u6218\u7565\u5408\u4f5c\uff0c\u4e3a\u56fd\u5185\u521b\u65b0\u6297\u4f53\u5076\u8054\u836f\u7269\u7814\u53d1\u4f01\u4e1a\u63d0\u4f9b\u65b0\u7684\u5408\u4f5c\u89e3\u51b3\u65b9\u6848\u3002 \u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADCs\uff09\u7531\u5355\u514b\u9686\u6297\u4f53(mAb)\u3001\u8fde\u63a5\u5b50(linker)\u548c\u7ec6\u80de\u6bd2\u6027\u5c0f\u5206\u5b50(cytotoxin\/payload)\u4e09\u90e8\u5206\u7ec4\u6210\uff0c\u901a\u8fc7\u5355\u514b\u9686\u6297\u4f53\u4e0e\u80bf\u7624\u7ec6\u80de\u8868\u9762\u7684\u7279\u5f02\u6027\u6297\u539f\u7ed3\u5408\uff0c\u5c06\u7ec6\u80de\u6bd2\u836f\u7269\u5b9a\u5411\u9012\u9001\u5230\u80bf\u7624\u75c5\u7076\u3002\u5bf9\u6bd4\u4f20\u7edf\u7684\u5316\u836f\u548c\u751f\u7269\u836f\uff0c\u660e\u663e\u63d0\u5347\u4e86\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002ADC\u9886\u57df\u5728\u8fd110\u5e74\u6765\u53d6\u5f97\u4e86\u5feb\u901f\u7684\u53d1\u5c55\uff0c\u6cbb\u7597\u7a97\u53e3\u4e0d\u65ad\u6269\u5927\uff0c\u6839\u636eEvaluate Pharma\u548cBCG\u7684\u9884\u6d4b\uff0c\u5168\u7403ADC\u5e02\u573a\u9884\u8ba12024\u5e74\u5c06\u8fbe\u5230129\u4ebf\u7f8e\u5143\uff0c2018\u81f32024\u5e74\u7684\u5e74\u590d\u5408\u589e\u957f\u7387\u7ea6\u4e3a35%\u3002 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More<\/a><\/p>\n","protected":false},"author":556,"featured_media":46507,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-46504","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/46504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=46504"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/46504\/revisions"}],"predecessor-version":[{"id":46506,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/46504\/revisions\/46506"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/46507"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=46504"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=46504"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=46504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}