{"id":45409,"date":"2021-09-24T07:43:00","date_gmt":"2021-09-24T00:43:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021092407430045409"},"modified":"2021-09-24T17:53:49","modified_gmt":"2021-09-24T09:53:49","slug":"%e5%ba%b7%e6%96%b9%e7%94%9f%e7%89%a9%e5%87%af%e5%be%97%e5%ae%81pd-1-ctla-4%e5%8f%8c%e6%8a%97%e6%b2%bb%e7%96%97%e5%ae%ab%e9%a2%88%e7%99%8c%e4%b8%8a%e5%b8%82%e7%94%b3%e8%af%b7%e8%8e%b7%e5%8f%97%e7%90%86","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021092407430045409","title":{"rendered":"\u5eb7\u65b9\u751f\u7269\u51ef\u5f97\u5b81PD-1\/CTLA-4\u53cc\u6297\u6cbb\u7597\u5bab\u9888\u764c\u4e0a\u5e02\u7533\u8bf7\u83b7\u53d7\u7406"},"content":{"rendered":"<p><p>\u9999\u6e2f2021\u5e749\u670824\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u5eb7\u65b9\u751f\u7269\uff089926.HK\uff09\u5ba3\u5e03\uff0c\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08\u201cNMPA\u201d\uff09\u5df2\u7ecf\u6b63\u5f0f\u53d7\u7406\u5168\u7403\u9996\u521b\u7684PD-1\/CTLA-4\u53cc\u7279\u5f02\u6027\u6297\u4f53\u51ef\u5f97\u5b81\u5355\u6297\uff08Candonilimab\uff0c\u7814\u53d1\u4ee3\u53f7\uff1aAK104\uff09\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u5bab\u9888\u764c\u7684\u4e0a\u5e02\u7533\u8bf7\uff0c\u5e76\u83b7\u4f18\u5148\u5ba1\u8bc4\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder9235\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/1634108\/image1.html\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/image1-821.jpg\" title=\"\" alt=\"\" \/><\/a><br \/><span><\/span><\/p>\n<\/p><\/div>\n<p>\u8fd9\u610f\u5473\u7740\uff0c\u5eb7\u65b9\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u5e76\u4ea7\u4e1a\u5316\u7684\u51ef\u5f97\u5b81\u5355\u6297\uff0c\u6210\u4e3a<span id=\"spanHghltb75a\">\u5168\u7403\u7b2c\u4e00\u4e2a<\/span>\u9012\u4ea4\u4e0a\u5e02\u7533\u8bf7\u7684\u57fa\u4e8ePD-1\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\u836f\u7269\uff0c\u4e5f\u6210\u4e3a\u4e2d\u56fd\u81ea\u4e3b\u7814\u53d1\u7684<span id=\"spanHghltf40a\">\u9996\u6b3e<\/span>\u53cc\u7279\u5f02\u6027\u6297\u4f53\u836f\u7269\u3002<\/p>\n<p>\u51ef\u5f97\u5b81\u5355\u6297\u5728\u5168\u7403\u7387\u5148\u63d0\u4ea4\u4e0a\u5e02\u5e76\u83b7\u5f97\u53d7\u7406\uff0c\u6807\u5fd7\u7740\u4e2d\u56fd\u751f\u7269\u5236\u836f\u6c34\u5e73\u5728\u5feb\u901f\u8d70\u5728\u4e16\u754c\u524d\u5217\uff0c\u5c06<span id=\"spanHghlt9ece\">\u6709\u529b<\/span>\u63a8\u52a8\u4e2d\u56fd\u751f\u7269\u533b\u836f\u4ea7\u4e1a\u5728\u5168\u7403\u5730\u4f4d\u7684\u63d0\u5347\uff0c\u4fc3\u8fdb\u4e2d\u56fd\u4ece\u5236\u836f\u5927\u56fd\u8d70\u5411\u5236\u836f\u5f3a\u56fd\uff0c\u52a9\u529b\u201c\u5065\u5eb7\u4e2d\u56fd2030\u201d\u6218\u7565\u7684\u5b9e\u73b0\u3002<\/p>\n<p>\u5bf9\u5eb7\u65b9\u751f\u7269\u800c\u8a00\uff0c\u51ef\u5f97\u5b81\u5355\u6297\u662f\u5eb7\u65b9\u751f\u7269\u7b2c\u4e8c\u6b3e\u63d0\u4ea4\u4e0a\u5e02\u7533\u8bf7\u7684\u81ea\u4e3b\u7814\u53d1\u7684\u521b\u65b0\u6297\u4f53\u836f\u7269\uff0c\u662f\u5eb7\u65b9\u751f\u7269\u5728\u4e2d\u56fd\u548c\u7f8e\u56fd\u63d0\u4ea4\u7684\u7b2c5\u4e2a\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u3002<\/p>\n<p>\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u663e\u793a\uff0c\u51ef\u5f97\u5b81\u5355\u6297\u6cbb\u7597\u7ecf\u542b\u94c2\u5316\u7597\u5931\u8d25\u7684\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u5bab\u9888\u764c\u60a3\u8005\u7684\u7597\u6548\u663e\u8457\uff0c\u4e14\u5b89\u5168\u6027\u826f\u597d\u3002\u5728\u76ee\u6807\u9002\u5e94\u75c7\u4eba\u7fa4\u4e2d\uff0c\u51ef\u5f97\u5b81\u5355\u6297\u4e0e\u5df2\u4e0a\u5e02PD-1\u5355\u6297\u516c\u5f00\u6570\u636e\u76f8\u6bd4\uff0c\u663e\u793a\u4e86\u66f4\u4f18\u7597\u6548\u3002\u76f8\u5173\u4e34\u5e8a\u6570\u636e\u5c06\u5728\u6709\u5173\u56fd\u9645\u4f1a\u8bae\u53ca\u671f\u520a\u4e0a\u53d1\u8868\u3002<\/p>\n<p>\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u80bf\u7624\u5987\u79d1\u4e3b\u4efb\u5434\u5c0f\u534e\u6559\u6388\u8868\u793a\uff0c\u5168\u7403\u8303\u56f4\u5185\uff0c\u867d\u7136\u6709\u6cbb\u7597\u5bab\u9888\u764c\u9002\u5e94\u75c7\u7684PD-1\u5355\u6297\u83b7\u6279\u4e0a\u5e02\uff0c\u4f46\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u663e\u793a\u5176\u4ec5\u57282\u7ebf\u4ee5\u4e0a\u7684PD-L1\u9633\u6027\u60a3\u8005\u4e2d\u53d6\u5f97\u4e0d\u8d85\u8fc715%\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\u3002\u51ef\u5f97\u5b81\u5355\u6297\u5728\u6ce8\u518c\u6027II\u671f\u4e34\u5e8a\u4e2d\u8868\u73b0\u51fa\u6765\u7684\u5355\u836f\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u6570\u636e\u4ee4\u4eba\u9f13\u821e\uff0c\u4e0d\u4ec5\u5728PD-L1\u9633\u6027\u4eba\u7fa4\u4e2d\u83b7\u5f97\u8f83\u9ad8\u7684\u54cd\u5e94\u7387\uff0c\u5728PD-L1\u9634\u6027\u4eba\u7fa4\u4e2d\u4e5f\u770b\u5230\u4e86\u4e0d\u4fd7\u7684\u6548\u679c\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e5f\u6709\u663e\u8457\u63d0\u5347\uff0c\u4e3a\u4e2d\u56fd\u665a\u671f\u5bab\u9888\u764c\u60a3\u8005\u5e26\u6765\u66f4\u597d\u7684\u6cbb\u7597\u624b\u6bb5\u30022030\u5e74\u662f\u300a\u52a0\u901f\u6d88\u9664\u5bab\u9888\u764c\u5168\u7403\u6218\u7565\u300b\u548c\u300a\u5065\u5eb7\u4e2d\u56fd2030\u300b\u7eb2\u8981\u7684\u5171\u540c\u5173\u952e\u8282\u70b9\uff0c\u76f8\u4fe1\u51ef\u5f97\u5b81\u5355\u6297\u4f5c\u4e3a<span id=\"spanHghltbe79\">\u6211\u56fd\u7b2c\u4e00\u4e2a<\/span>\u81ea\u4e3b\u7814\u53d1\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\u4ea7\u54c1\uff0c\u80fd\u52a9\u529b\u5bab\u9888\u764c\u5168\u7403\u548c\u4e2d\u56fd\u5065\u5eb7\u6218\u7565\u7684\u987a\u5229\u5b9e\u73b0\u3002<\/p>\n<p>\u4e2d\u534e\u533b\u5b66\u4f1a\u5987\u79d1\u80bf\u7624\u5b66\u5206\u4f1a\u5019\u4efb\u4e3b\u4efb\u59d4\u5458\u3001\u5c71\u4e1c\u5927\u5b66\u9f50\u9c81\u533b\u9662\u5987\u4ea7\u79d1\u5b54\u5317\u534e\u6559\u6388\u8868\u793a\uff0c\u5b50\u5bab\u9888\u764c\u662f\u6211\u56fd\u53d1\u75c5\u7387\u6700\u9ad8\u7684\u5987\u79d1\u6076\u6027\u80bf\u7624\uff0c\u665a\u671f\u8f6c\u79fb\u590d\u53d1\u60a3\u8005\u5e38\u89c4\u6cbb\u7597\u96be\u4ee5\u6cbb\u6108\uff0c\u662f\u5987\u79d1\u80bf\u7624\u533b\u751f\u9762\u4e34\u7684\u6700\u5927\u6311\u6218\u4e4b\u4e00\uff0c\u5b58\u5728\u91cd\u5927\u4e34\u5e8a\u9700\u6c42\u3002\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5355\u836f\u6cbb\u7597\u4e34\u5e8a\u7597\u6548\u4e0d\u5c3d\u6ee1\u610f\uff0c\u8054\u5408\u5e94\u7528\u867d\u7136\u6709\u671b\u63d0\u9ad8\u7597\u6548\u4f46\u6bd2\u526f\u4f5c\u7528\u4e25\u91cd\uff0c\u5927\u5927\u9650\u5236\u4e86\u5176\u4e34\u5e8a\u5e94\u7528\u3002\u51ef\u5f97\u5b81\u5355\u6297\u7ecf\u4e34\u5e8a\u8bd5\u9a8c\u8bc1\u660e\u5bf9\u665a\u671f\u8f6c\u79fb\u590d\u53d1\u5e38\u89c4\u6cbb\u7597\u5931\u8d25\u7684\u5b50\u5bab\u9888\u764c\u60a3\u8005\u6709\u6548\u7387\u9ad8\uff0c\u6bd2\u526f\u53cd\u5e94\u4f4e\uff0c\u5b89\u5168\u53ef\u63a7\uff0c\u5df2\u8fdb\u5165\u56fd\u5bb6\u5feb\u901f\u5ba1\u6279\u7a0b\u5e8f\uff0c\u8fd9\u662f\u533b\u751f\u7684\u559c\u8baf\uff0c\u662f\u60a3\u8005\u7684\u798f\u97f3\uff0c\u8fd9\u5c06\u5f15\u9886\u6211\u56fd\u80bf\u7624\u6cbb\u7597\u5728\u56fd\u9645\u4e0a\u7387\u5148\u8fdb\u5165\u514d\u75ab\u6cbb\u7597\u65b0\u65f6\u4ee3\uff0c\u63d0\u5347\u6211\u56fd\u5b50\u5bab\u9888\u764c\u7684\u9632\u6cbb\u6c34\u5e73\uff0c\u9020\u798f\u5e7f\u5927\u60a3\u8005\uff0c\u53ef\u559c\u53ef\u8d3a\u3002<\/p>\n<p>\u5eb7\u65b9\u751f\u7269\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u957f\u517c\u804c\u9996\u5e2d\u6267\u884c\u5b98\u590f\u745c\u535a\u58eb\u6b23\u559c\u5730\u6307\u51fa\uff1a\u51ef\u5f97\u5b81\u5355\u6297\u7531\u5eb7\u65b9\u751f\u7269\u79d1\u5b66\u5bb6\u591a\u5e74\u6f5c\u5fc3\u7814\u7a76\u5f00\u53d1\uff0c\u662f\u5177\u6709\u5168\u7403\u4e13\u5229\u7684\u540c\u65f6\u9776\u5411PD-1\/CTLA-4\u7684\u5355\u514b\u9686\u6297\u4f53\u65b0\u836f\uff0c\u4e5f\u662f\u5168\u7403\u9996\u4e2a\u7533\u8bf7\u4e0a\u5e02\u7684\u9488\u5bf9PD-1\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\u3002\u975e\u5e38\u611f\u8c22\u5eb7\u65b9\u56e2\u961f\u3001\u4e34\u5e8a\u7814\u7a76\u4e2d\u5fc3\u548c\u533b\u5b66\u4e13\u5bb6\u53ca\u5404\u7ea7\u836f\u76d1\u90e8\u95e8\u4e3a\u6b64\u505a\u51fa\u7684\u5353\u8d8a\u52aa\u529b\u3002\u5eb7\u65b9\u751f\u7269\u5c06\u5145\u5206\u53d1\u6325\u5728\u53cc\u7279\u5f02\u6027\u6297\u4f53\u9886\u57df\u7684\u9886\u5148\u4f18\u52bf\uff0c\u52a0\u901f\u63a8\u8fdb\u51ef\u5f97\u5b81\u5355\u6297\u5728\u5176\u4ed6\u9002\u5e94\u75c7\u7684\u4e34\u5e8a\u7814\u7a76\u3002\u6211\u4eec\u671f\u5f85\u51ef\u5f97\u5b81\u5355\u6297\u5728\u80bf\u7624\u53cc\u514d\u75ab\u6297\u4f53\u6cbb\u7597\u7684\u4f18\u52bf\u9020\u798f\u66f4\u591a\u7684\u80bf\u7624\u60a3\u8005\u3002<\/p>\n<p>\u51ef\u5f97\u5b81\u5355\u6297\u6cbb\u7597\u5bab\u9888\u764c\u76f8\u5173\u4e3b\u8981\u91cc\u7a0b\u7891\uff1a<\/p>\n<p>2021\u5e747\u6708\uff0c\u51ef\u5f97\u5b81\u5355\u6297\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u5bab\u9888\u764c\u7684III\u671f\u4e34\u5e8a\u6b63\u5f0f\u542f\u52a8<\/p>\n<p>2021\u5e742\u6708\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6388\u4e88\u51ef\u5f97\u5b81\u5355\u6297\u6cbb\u7597\u5bab\u9888\u764c\u7684\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a<\/p>\n<p>2020\u5e747\u6708\uff0cFDA\u6388\u4e88\u51ef\u5f97\u5b81\u5355\u6297\u6cbb\u7597\u7ecf\u542b\u94c2\u5316\u7597\u6cbb\u7597\u5931\u8d25\u7684\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u5bab\u9888\u764c\u7684\u5feb\u901f\u5ba1\u6279\u901a\u9053\u8d44\u683c<\/p>\n<p>2020\u5e7410\u6708\uff0c\u51ef\u5f97\u5b81\u5355\u6297\u7528\u4e8e\u7ecf\u6807\u51c6\u6cbb\u7597\u540e\u7684\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u5bab\u9888\u9cde\u764c\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u5ba1\u6838\u6279\u51c6\u7eb3\u5165\u201c\u7a81\u7834\u6027\u6cbb\u7597\u54c1\u79cd\u201d\u540d\u5355\u3002<\/p>\n<p>\u76ee\u524d\uff0c\u51ef\u5f97\u5b81\u5355\u6297\u5e03\u5c40\u7684\u4e3b\u8981\u9002\u5e94\u75c7\u8fd8\u5305\u62ec\u80c3\u764c\u3001\u80ba\u764c\u3001\u809d\u764c\u3001\u98df\u7ba1\u9cde\u764c\u53ca\u9f3b\u54bd\u764c\u7b49\u3002\u5176\u4e2d\uff0c\u51ef\u5f97\u5b81\u5355\u6297\u6cbb\u7597\u4e00\u7ebf\u80c3\u764c\u7684III\u671f\u4e34\u5e8a\u4e5f\u5df2\u7ecf\u6b63\u5f0f\u542f\u52a8\u3002<\/p>\n<p><b>\u5173\u4e8e\u51ef\u5f97\u5b81\u5355\u6297\uff08<\/b><b>PD-1\/CTLA-4\u53cc\u6297\uff09<\/b><\/p>\n<p>\u51ef\u5f97\u5b81\u5355\u6297&nbsp;(AK104)\u662f\u5eb7\u65b9\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u7684\u65b0\u578b\u7684\u3001\u9996\u521b\u7684PD-1\/CTLA-4\u53cc\u7279\u5f02\u6027\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u9aa8\u5e72\u836f\u7269\uff0c\u4e3b\u8981\u9002\u5e94\u75c7\u5305\u62ec\u80ba\u764c\u3001\u809d\u764c\u3001\u80c3\u764c\u3001\u5bab\u9888\u764c\u3001\u80be\u764c\u3001\u98df\u7ba1\u9cde\u764c\u53ca\u9f3b\u54bd\u764c\u7b49\u591a\u79cd\u6076\u6027\u80bf\u7624\uff0c\u76f8\u5173\u80bf\u7624\u7684\u7814\u7a76\u9636\u6bb5\u6027\u6570\u636e\u663e\u793a\uff0c\u51ef\u5f97\u5b81\u5355<span id=\"spanHghltf475\">\u6297\u4e0e<\/span>PD-1\u8054\u5408CTLA-4\u7684\u8054\u5408\u7597\u6cd5\u76f8\u6bd4\uff0c\u6bd2\u6027\u663e\u8457\u964d\u4f4e\uff0c\u5177\u6709\u660e\u663e\u7684\u5b89\u5168\u6027\u548c\u7597\u6548\u4f18\u52bf\u3002\u51ef\u5f97\u5b81\u5355\u6297\u662f2017\u5e74\u56fd\u5bb6\u536b\u5065\u59d4\u53ca\u79d1\u6280\u90e8\u5341\u4e09\u4e94<span id=\"spanHghlt5ee2\">\u201c<\/span>\u91cd\u5927\u65b0\u836f\u521b\u5236<span id=\"spanHghltb541\">\u201d<\/span>\u79d1\u6280<span id=\"spanHghltf3d3\">\u91cd\u5927<\/span>\u4e13\u9879\u652f\u6301\u9879\u76ee\uff0c\u4e5f\u662f2017\u5e74\u5e7f\u4e1c\u7701<span id=\"spanHghlt5ee2\">\u201c<\/span>\u73e0\u6c5f\u4eba\u624d\u8ba1\u5212<span id=\"spanHghltb541\">\u201d<\/span>\u5f15\u8fdb\u521b\u65b0\u521b\u4e1a\u56e2\u961f\u652f\u6301\u9879\u76ee\u3002\u51ef\u5f97\u5b81\u5355\u6297\u7684\u7814\u53d1\u88ab\u4e2d\u56fd\u533b\u836f\u751f\u7269\u6280\u672f\u534f\u4f1a\u548c\u300a\u4e2d\u56fd\u533b\u836f\u751f\u7269\u6280\u672f\u300b\u6742\u5fd7\u5171\u540c\u8bc4\u4e3a<span id=\"spanHghlt5ee2\">\u201c<\/span>2017\u5e74\u4e2d\u56fd\u533b\u836f\u751f\u7269\u6280\u672f\u5341\u5927\u8fdb\u5c55<span id=\"spanHghltb541\">\u201d<\/span>\u4e4b\u4e00\u3002<\/p>\n<p><b>\u5173\u4e8e\u5eb7\u65b9\u751f\u7269<\/b><\/p>\n<p>\u5eb7\u65b9\u751f\u7269\uff08\u6e2f\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a9926.HK\uff09\u662f\u4e00\u5bb6\u81f4\u529b\u4e8e\u7814\u7a76\u3001\u5f00\u53d1\u3001\u751f\u4ea7\u53ca\u5546\u4e1a\u5316\u5168\u7403\u75c5\u4eba\u53ef\u8d1f\u62c5\u7684\u521b\u65b0\u6297\u4f53\u65b0\u836f\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u3002\u81ea\u6210\u7acb\u4ee5\u6765\uff0c\u516c\u53f8\u5efa\u7acb\u4e86\u7aef\u5bf9\u7aef\u5168\u65b9\u4f4d\u7684\u836f\u7269\u5f00\u53d1\u5e73\u53f0\uff08ACE\u5e73\u53f0\uff09\uff0c\u6db5\u76d6\u4e86\u5168\u9762\u4e00\u4f53\u5316\u7684\u836f\u7269\u53d1\u73b0\u548c\u5f00\u53d1\u529f\u80fd\uff0c\u5305\u62ec\u9776\u70b9\u9a8c\u8bc1\u3001\u6297\u4f53\u53d1\u73b0\u4e0e\u5f00\u53d1\u3001CMC\u751f\u4ea7\u5de5\u827a\u5f00\u53d1\u548c\u7b26\u5408GMP\u6807\u51c6\u7684\u89c4\u6a21\u5316\u751f\u4ea7\u3002\u516c\u53f8\u4e5f\u6210\u529f\u5efa\u7acb\u4e86\u53cc\u7279\u5f02\u6297\u4f53\u836f\u7269\u5f00\u53d1\u5e73\u53f0\uff08Tetrabody\u5e73\u53f0\uff09\u3002\u516c\u53f8\u76ee\u524d\u62e5\u670920\u4e2a\u4ee5\u4e0a\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u708e\u75c7\u3001\u4ee3\u8c22\u75be\u75c5\u7b49\u91cd\u5927\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u5176\u4e2d13\u4e2a\u54c1\u79cd\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\uff0c\u5305\u62ec\u4e24\u4e2a\u56fd\u9645\u9996\u521b\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\u65b0\u836f\uff08PD-1\/CTLA-4\u4ee5\u53caPD-1\/VEGF\uff09\u30022021\u5e748\u6708\uff0c\u516c\u53f8\u9996\u6b3e\u81ea\u4e3b\u521b\u65b0\u7814\u53d1\u7684\u5dee\u5f02\u5316PD-1\u5355\u514b\u9686\u6297\u4f53\u6d3e\u5b89\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u5b89\u5c3c\u53ef\uff09\u5df2\u83b7\u6279\u4e0a\u5e02\u3002\u5eb7\u65b9\u751f\u7269\u671f\u671b\u901a\u8fc7\u9ad8\u6548\u53ca\u7a81\u7834\u6027\u7684\u7814\u53d1\u521b\u65b0\u5f00\u53d1\u56fd\u9645\u9996\u521b\u53ca\u540c\u7c7b\u836f\u7269\u6700\u4f73\u7597\u6cd5\u7684\u65b0\u836f\uff0c\u6210\u4e3a\u5168\u7403\u9886\u5148\u7684\u751f\u7269\u5236\u836f\u4f01\u4e1a\u3002<\/p>\n<p>&nbsp;<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder0\">  <\/div>\n<p>\u76f8\u5173\u94fe\u63a5 :<\/p>\n<p>http:\/\/www.akesobio.com<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u9999\u6e2f2021\u5e749\u670824\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u5eb7\u65b9\u751f\u7269\uff089926.HK\uff09\u5ba3\u5e03\uff0c\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08\u201cNMPA\u201d\uff09\u5df2\u7ecf\u6b63\u5f0f\u53d7\u7406\u5168\u7403\u9996\u521b\u7684PD-1\/CTLA-4\u53cc\u7279\u5f02\u6027\u6297\u4f53\u51ef\u5f97\u5b81\u5355\u6297\uff08Candonilimab\uff0c\u7814\u53d1\u4ee3\u53f7\uff1aAK104\uff09\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u5bab\u9888\u764c\u7684\u4e0a\u5e02\u7533\u8bf7\uff0c\u5e76\u83b7\u4f18\u5148\u5ba1\u8bc4\u3002 \u8fd9\u610f\u5473\u7740\uff0c\u5eb7\u65b9\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u5e76\u4ea7\u4e1a\u5316\u7684\u51ef\u5f97\u5b81\u5355\u6297\uff0c\u6210\u4e3a\u5168\u7403\u7b2c\u4e00\u4e2a\u9012\u4ea4\u4e0a\u5e02\u7533\u8bf7\u7684\u57fa\u4e8ePD-1\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\u836f\u7269\uff0c\u4e5f\u6210\u4e3a\u4e2d\u56fd\u81ea\u4e3b\u7814\u53d1\u7684\u9996\u6b3e\u53cc\u7279\u5f02\u6027\u6297\u4f53\u836f\u7269\u3002 \u51ef\u5f97\u5b81\u5355\u6297\u5728\u5168\u7403\u7387\u5148\u63d0\u4ea4\u4e0a\u5e02\u5e76\u83b7\u5f97\u53d7\u7406\uff0c\u6807\u5fd7\u7740\u4e2d\u56fd\u751f\u7269\u5236\u836f\u6c34\u5e73\u5728\u5feb\u901f\u8d70\u5728\u4e16\u754c\u524d\u5217\uff0c\u5c06\u6709\u529b\u63a8\u52a8\u4e2d\u56fd\u751f\u7269\u533b\u836f\u4ea7\u4e1a\u5728\u5168\u7403\u5730\u4f4d\u7684\u63d0\u5347\uff0c\u4fc3\u8fdb\u4e2d\u56fd\u4ece\u5236\u836f\u5927\u56fd\u8d70\u5411\u5236\u836f\u5f3a\u56fd\uff0c\u52a9\u529b\u201c\u5065\u5eb7\u4e2d\u56fd2030\u201d\u6218\u7565\u7684\u5b9e\u73b0\u3002 \u5bf9\u5eb7\u65b9\u751f\u7269\u800c\u8a00\uff0c\u51ef\u5f97\u5b81\u5355\u6297\u662f\u5eb7\u65b9\u751f\u7269\u7b2c\u4e8c\u6b3e\u63d0\u4ea4\u4e0a\u5e02\u7533\u8bf7\u7684\u81ea\u4e3b\u7814\u53d1\u7684\u521b\u65b0\u6297\u4f53\u836f\u7269\uff0c\u662f\u5eb7\u65b9\u751f\u7269\u5728\u4e2d\u56fd\u548c\u7f8e\u56fd\u63d0\u4ea4\u7684\u7b2c5\u4e2a\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u3002 \u4e34\u5e8a\u7814\u7a76\u6570\u636e\u663e\u793a\uff0c\u51ef\u5f97\u5b81\u5355\u6297\u6cbb\u7597\u7ecf\u542b\u94c2\u5316\u7597\u5931\u8d25\u7684\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u5bab\u9888\u764c\u60a3\u8005\u7684\u7597\u6548\u663e\u8457\uff0c\u4e14\u5b89\u5168\u6027\u826f\u597d\u3002\u5728\u76ee\u6807\u9002\u5e94\u75c7\u4eba\u7fa4\u4e2d\uff0c\u51ef\u5f97\u5b81\u5355\u6297\u4e0e\u5df2\u4e0a\u5e02PD-1\u5355\u6297\u516c\u5f00\u6570\u636e\u76f8\u6bd4\uff0c\u663e\u793a\u4e86\u66f4\u4f18\u7597\u6548\u3002\u76f8\u5173\u4e34\u5e8a\u6570\u636e\u5c06\u5728\u6709\u5173\u56fd\u9645\u4f1a\u8bae\u53ca\u671f\u520a\u4e0a\u53d1\u8868\u3002 \u590d\u65e6\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u80bf\u7624\u5987\u79d1\u4e3b\u4efb\u5434\u5c0f\u534e\u6559\u6388\u8868\u793a\uff0c\u5168\u7403\u8303\u56f4\u5185\uff0c\u867d\u7136\u6709\u6cbb\u7597\u5bab\u9888\u764c\u9002\u5e94\u75c7\u7684PD-1\u5355\u6297\u83b7\u6279\u4e0a\u5e02\uff0c\u4f46\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u663e\u793a\u5176\u4ec5\u57282\u7ebf\u4ee5\u4e0a\u7684PD-L1\u9633\u6027\u60a3\u8005\u4e2d\u53d6\u5f97\u4e0d\u8d85\u8fc715%\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\u3002\u51ef\u5f97\u5b81\u5355\u6297\u5728\u6ce8\u518c\u6027II\u671f\u4e34\u5e8a\u4e2d\u8868\u73b0\u51fa\u6765\u7684\u5355\u836f\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u6570\u636e\u4ee4\u4eba\u9f13\u821e\uff0c\u4e0d\u4ec5\u5728PD-L1\u9633\u6027\u4eba\u7fa4\u4e2d\u83b7\u5f97\u8f83\u9ad8\u7684\u54cd\u5e94\u7387\uff0c\u5728PD-L1\u9634\u6027\u4eba\u7fa4\u4e2d\u4e5f\u770b\u5230\u4e86\u4e0d\u4fd7\u7684\u6548\u679c\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e5f\u6709\u663e\u8457\u63d0\u5347\uff0c\u4e3a\u4e2d\u56fd\u665a\u671f\u5bab\u9888\u764c\u60a3\u8005\u5e26\u6765\u66f4\u597d\u7684\u6cbb\u7597\u624b\u6bb5\u30022030\u5e74\u662f\u300a\u52a0\u901f\u6d88\u9664\u5bab\u9888\u764c\u5168\u7403\u6218\u7565\u300b\u548c\u300a\u5065\u5eb7\u4e2d\u56fd2030\u300b\u7eb2\u8981\u7684\u5171\u540c\u5173\u952e\u8282\u70b9\uff0c\u76f8\u4fe1\u51ef\u5f97\u5b81\u5355\u6297\u4f5c\u4e3a\u6211\u56fd\u7b2c\u4e00\u4e2a\u81ea\u4e3b\u7814\u53d1\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\u4ea7\u54c1\uff0c\u80fd\u52a9\u529b\u5bab\u9888\u764c\u5168\u7403\u548c\u4e2d\u56fd\u5065\u5eb7\u6218\u7565\u7684\u987a\u5229\u5b9e\u73b0\u3002 \u4e2d\u534e\u533b\u5b66\u4f1a\u5987\u79d1\u80bf\u7624\u5b66\u5206\u4f1a\u5019\u4efb\u4e3b\u4efb\u59d4\u5458\u3001\u5c71\u4e1c\u5927\u5b66\u9f50\u9c81\u533b\u9662\u5987\u4ea7\u79d1\u5b54\u5317\u534e\u6559\u6388\u8868\u793a\uff0c\u5b50\u5bab\u9888\u764c\u662f\u6211\u56fd\u53d1\u75c5\u7387\u6700\u9ad8\u7684\u5987\u79d1\u6076\u6027\u80bf\u7624\uff0c\u665a\u671f\u8f6c\u79fb\u590d\u53d1\u60a3\u8005\u5e38\u89c4\u6cbb\u7597\u96be\u4ee5\u6cbb\u6108\uff0c\u662f\u5987\u79d1\u80bf\u7624\u533b\u751f\u9762\u4e34\u7684\u6700\u5927\u6311\u6218\u4e4b\u4e00\uff0c\u5b58\u5728\u91cd\u5927\u4e34\u5e8a\u9700\u6c42\u3002\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5355\u836f\u6cbb\u7597\u4e34\u5e8a\u7597\u6548\u4e0d\u5c3d\u6ee1\u610f\uff0c\u8054\u5408\u5e94\u7528\u867d\u7136\u6709\u671b\u63d0\u9ad8\u7597\u6548\u4f46\u6bd2\u526f\u4f5c\u7528\u4e25\u91cd\uff0c\u5927\u5927\u9650\u5236\u4e86\u5176\u4e34\u5e8a\u5e94\u7528\u3002\u51ef\u5f97\u5b81\u5355\u6297\u7ecf\u4e34\u5e8a\u8bd5\u9a8c\u8bc1\u660e\u5bf9\u665a\u671f\u8f6c\u79fb\u590d\u53d1\u5e38\u89c4\u6cbb\u7597\u5931\u8d25\u7684\u5b50\u5bab\u9888\u764c\u60a3\u8005\u6709\u6548\u7387\u9ad8\uff0c\u6bd2\u526f\u53cd\u5e94\u4f4e\uff0c\u5b89\u5168\u53ef\u63a7\uff0c\u5df2\u8fdb\u5165\u56fd\u5bb6\u5feb\u901f\u5ba1\u6279\u7a0b\u5e8f\uff0c\u8fd9\u662f\u533b\u751f\u7684\u559c\u8baf\uff0c\u662f\u60a3\u8005\u7684\u798f\u97f3\uff0c\u8fd9\u5c06\u5f15\u9886\u6211\u56fd\u80bf\u7624\u6cbb\u7597\u5728\u56fd\u9645\u4e0a\u7387\u5148\u8fdb\u5165\u514d\u75ab\u6cbb\u7597\u65b0\u65f6\u4ee3\uff0c\u63d0\u5347\u6211\u56fd\u5b50\u5bab\u9888\u764c\u7684\u9632\u6cbb\u6c34\u5e73\uff0c\u9020\u798f\u5e7f\u5927\u60a3\u8005\uff0c\u53ef\u559c\u53ef\u8d3a\u3002 \u5eb7\u65b9\u751f\u7269\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u957f\u517c\u804c\u9996\u5e2d\u6267\u884c\u5b98\u590f\u745c\u535a\u58eb\u6b23\u559c\u5730\u6307\u51fa\uff1a\u51ef\u5f97\u5b81\u5355\u6297\u7531\u5eb7\u65b9\u751f\u7269\u79d1\u5b66\u5bb6\u591a\u5e74\u6f5c\u5fc3\u7814\u7a76\u5f00\u53d1\uff0c\u662f\u5177\u6709\u5168\u7403\u4e13\u5229\u7684\u540c\u65f6\u9776\u5411PD-1\/CTLA-4\u7684\u5355\u514b\u9686\u6297\u4f53\u65b0\u836f\uff0c\u4e5f\u662f\u5168\u7403\u9996\u4e2a\u7533\u8bf7\u4e0a\u5e02\u7684\u9488\u5bf9PD-1\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\u3002\u975e\u5e38\u611f\u8c22\u5eb7\u65b9\u56e2\u961f\u3001\u4e34\u5e8a\u7814\u7a76\u4e2d\u5fc3\u548c\u533b\u5b66\u4e13\u5bb6\u53ca\u5404\u7ea7\u836f\u76d1\u90e8\u95e8\u4e3a\u6b64\u505a\u51fa\u7684\u5353\u8d8a\u52aa\u529b\u3002\u5eb7\u65b9\u751f\u7269\u5c06\u5145\u5206\u53d1\u6325\u5728\u53cc\u7279\u5f02\u6027\u6297\u4f53\u9886\u57df\u7684\u9886\u5148\u4f18\u52bf\uff0c\u52a0\u901f\u63a8\u8fdb\u51ef\u5f97\u5b81\u5355\u6297\u5728\u5176\u4ed6\u9002\u5e94\u75c7\u7684\u4e34\u5e8a\u7814\u7a76\u3002\u6211\u4eec\u671f\u5f85\u51ef\u5f97\u5b81\u5355\u6297\u5728\u80bf\u7624\u53cc\u514d\u75ab\u6297\u4f53\u6cbb\u7597\u7684\u4f18\u52bf\u9020\u798f\u66f4\u591a\u7684\u80bf\u7624\u60a3\u8005\u3002 \u51ef\u5f97\u5b81\u5355\u6297\u6cbb\u7597\u5bab\u9888\u764c\u76f8\u5173\u4e3b\u8981\u91cc\u7a0b\u7891\uff1a 2021\u5e747\u6708\uff0c\u51ef\u5f97\u5b81\u5355\u6297\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u5bab\u9888\u764c\u7684III\u671f\u4e34\u5e8a\u6b63\u5f0f\u542f\u52a8 2021\u5e742\u6708\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6388\u4e88\u51ef\u5f97\u5b81\u5355\u6297\u6cbb\u7597\u5bab\u9888\u764c\u7684\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a 2020\u5e747\u6708\uff0cFDA\u6388\u4e88\u51ef\u5f97\u5b81\u5355\u6297\u6cbb\u7597\u7ecf\u542b\u94c2\u5316\u7597\u6cbb\u7597\u5931\u8d25\u7684\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u5bab\u9888\u764c\u7684\u5feb\u901f\u5ba1\u6279\u901a\u9053\u8d44\u683c 2020\u5e7410\u6708\uff0c\u51ef\u5f97\u5b81\u5355\u6297\u7528\u4e8e\u7ecf\u6807\u51c6\u6cbb\u7597\u540e\u7684\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u5bab\u9888\u9cde\u764c\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u5ba1\u6838\u6279\u51c6\u7eb3\u5165\u201c\u7a81\u7834\u6027\u6cbb\u7597\u54c1\u79cd\u201d\u540d\u5355\u3002 \u76ee\u524d\uff0c\u51ef\u5f97\u5b81\u5355\u6297\u5e03\u5c40\u7684\u4e3b\u8981\u9002\u5e94\u75c7\u8fd8\u5305\u62ec\u80c3\u764c\u3001\u80ba\u764c\u3001\u809d\u764c\u3001\u98df\u7ba1\u9cde\u764c\u53ca\u9f3b\u54bd\u764c\u7b49\u3002\u5176\u4e2d\uff0c\u51ef\u5f97\u5b81\u5355\u6297\u6cbb\u7597\u4e00\u7ebf\u80c3\u764c\u7684III\u671f\u4e34\u5e8a\u4e5f\u5df2\u7ecf\u6b63\u5f0f\u542f\u52a8\u3002 \u5173\u4e8e\u51ef\u5f97\u5b81\u5355\u6297\uff08PD-1\/CTLA-4\u53cc\u6297\uff09 \u51ef\u5f97\u5b81\u5355\u6297&nbsp;(AK104)\u662f\u5eb7\u65b9\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u7684\u65b0\u578b\u7684\u3001\u9996\u521b\u7684PD-1\/CTLA-4\u53cc\u7279\u5f02\u6027\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u9aa8\u5e72\u836f\u7269\uff0c\u4e3b\u8981\u9002\u5e94\u75c7\u5305\u62ec\u80ba\u764c\u3001\u809d\u764c\u3001\u80c3\u764c\u3001\u5bab\u9888\u764c\u3001\u80be\u764c\u3001\u98df\u7ba1\u9cde\u764c\u53ca\u9f3b\u54bd\u764c\u7b49\u591a\u79cd\u6076\u6027\u80bf\u7624\uff0c\u76f8\u5173\u80bf\u7624\u7684\u7814\u7a76\u9636\u6bb5\u6027\u6570\u636e\u663e\u793a\uff0c\u51ef\u5f97\u5b81\u5355\u6297\u4e0ePD-1\u8054\u5408CTLA-4\u7684\u8054\u5408\u7597\u6cd5\u76f8\u6bd4\uff0c\u6bd2\u6027\u663e\u8457\u964d\u4f4e\uff0c\u5177\u6709\u660e\u663e\u7684\u5b89\u5168\u6027\u548c\u7597\u6548\u4f18\u52bf\u3002\u51ef\u5f97\u5b81\u5355\u6297\u662f2017\u5e74\u56fd\u5bb6\u536b\u5065\u59d4\u53ca\u79d1\u6280\u90e8\u5341\u4e09\u4e94\u201c\u91cd\u5927\u65b0\u836f\u521b\u5236\u201d\u79d1\u6280\u91cd\u5927\u4e13\u9879\u652f\u6301\u9879\u76ee\uff0c\u4e5f\u662f2017\u5e74\u5e7f\u4e1c\u7701\u201c\u73e0\u6c5f\u4eba\u624d\u8ba1\u5212\u201d\u5f15\u8fdb\u521b\u65b0\u521b\u4e1a\u56e2\u961f\u652f\u6301\u9879\u76ee\u3002\u51ef\u5f97\u5b81\u5355\u6297\u7684\u7814\u53d1\u88ab\u4e2d\u56fd\u533b\u836f\u751f\u7269\u6280\u672f\u534f\u4f1a\u548c\u300a\u4e2d\u56fd\u533b\u836f\u751f\u7269\u6280\u672f\u300b\u6742\u5fd7\u5171\u540c\u8bc4\u4e3a\u201c2017\u5e74\u4e2d\u56fd\u533b\u836f\u751f\u7269\u6280\u672f\u5341\u5927\u8fdb\u5c55\u201d\u4e4b\u4e00\u3002 \u5173\u4e8e\u5eb7\u65b9\u751f\u7269 \u5eb7\u65b9\u751f\u7269\uff08\u6e2f\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a9926.HK\uff09\u662f\u4e00\u5bb6\u81f4\u529b\u4e8e\u7814\u7a76\u3001\u5f00\u53d1\u3001\u751f\u4ea7\u53ca\u5546\u4e1a\u5316\u5168\u7403\u75c5\u4eba\u53ef\u8d1f\u62c5\u7684\u521b\u65b0\u6297\u4f53\u65b0\u836f\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u3002\u81ea\u6210\u7acb\u4ee5\u6765\uff0c\u516c\u53f8\u5efa\u7acb\u4e86\u7aef\u5bf9\u7aef\u5168\u65b9\u4f4d\u7684\u836f\u7269\u5f00\u53d1\u5e73\u53f0\uff08ACE\u5e73\u53f0\uff09\uff0c\u6db5\u76d6\u4e86\u5168\u9762\u4e00\u4f53\u5316\u7684\u836f\u7269\u53d1\u73b0\u548c\u5f00\u53d1\u529f\u80fd\uff0c\u5305\u62ec\u9776\u70b9\u9a8c\u8bc1\u3001\u6297\u4f53\u53d1\u73b0\u4e0e\u5f00\u53d1\u3001CMC\u751f\u4ea7\u5de5\u827a\u5f00\u53d1\u548c\u7b26\u5408GMP\u6807\u51c6\u7684\u89c4\u6a21\u5316\u751f\u4ea7\u3002\u516c\u53f8\u4e5f\u6210\u529f\u5efa\u7acb\u4e86\u53cc\u7279\u5f02\u6297\u4f53\u836f\u7269\u5f00\u53d1\u5e73\u53f0\uff08Tetrabody\u5e73\u53f0\uff09\u3002\u516c\u53f8\u76ee\u524d\u62e5\u670920\u4e2a\u4ee5\u4e0a\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u708e\u75c7\u3001\u4ee3\u8c22\u75be\u75c5\u7b49\u91cd\u5927\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u5176\u4e2d13\u4e2a\u54c1\u79cd\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\uff0c\u5305\u62ec\u4e24\u4e2a\u56fd\u9645\u9996\u521b\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\u65b0\u836f\uff08PD-1\/CTLA-4\u4ee5\u53caPD-1\/VEGF\uff09\u30022021\u5e748\u6708\uff0c\u516c\u53f8\u9996\u6b3e\u81ea\u4e3b\u521b\u65b0\u7814\u53d1\u7684\u5dee\u5f02\u5316PD-1\u5355\u514b\u9686\u6297\u4f53\u6d3e\u5b89\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u5b89\u5c3c\u53ef\uff09\u5df2\u83b7\u6279\u4e0a\u5e02\u3002\u5eb7\u65b9\u751f\u7269\u671f\u671b\u901a\u8fc7\u9ad8\u6548\u53ca\u7a81\u7834\u6027\u7684\u7814\u53d1\u521b\u65b0\u5f00\u53d1\u56fd\u9645\u9996\u521b\u53ca\u540c\u7c7b\u836f\u7269\u6700\u4f73\u7597\u6cd5\u7684\u65b0\u836f\uff0c\u6210\u4e3a\u5168\u7403\u9886\u5148\u7684\u751f\u7269\u5236\u836f\u4f01\u4e1a\u3002 &nbsp; \u76f8\u5173\u94fe\u63a5 : http:\/\/www.akesobio.com&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2021092407430045409\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":45412,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-45409","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/45409","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=45409"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/45409\/revisions"}],"predecessor-version":[{"id":45411,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/45409\/revisions\/45411"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/45412"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=45409"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=45409"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=45409"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}