{"id":44970,"date":"2021-09-20T07:14:00","date_gmt":"2021-09-20T00:14:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021092007140044970"},"modified":"2021-09-20T17:52:47","modified_gmt":"2021-09-20T09:52:47","slug":"%e7%a7%91%e6%b5%8e%e8%8d%af%e4%b8%9act041-car-t%e6%b2%bb%e7%96%97%e6%b6%88%e5%8c%96%e7%b3%bb%e7%bb%9f%e8%82%bf%e7%98%a4-%e6%99%9a%e6%9c%9f%e8%83%83%e7%99%8c%e7%96%97%e6%95%88%e6%95%b0%e6%8d%ae","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021092007140044970","title":{"rendered":"\u79d1\u6d4e\u836f\u4e1aCT041 CAR-T\u6cbb\u7597\u6d88\u5316\u7cfb\u7edf\u80bf\u7624 \u665a\u671f\u80c3\u764c\u7597\u6548\u6570\u636e\u4eae\u773c"},"content":{"rendered":"

ESMO\u53e3\u5934\u62a5\u544a<\/span><\/p>\n

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\n

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\n

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\u6211\u56fd\u662f\u80c3\u764c\u7684\u9ad8\u53d1\u56fd\u5bb6\uff0c\u5927\u591a\u6570\u60a3\u8005\u786e\u8bca\u65f6\u5df2\u5c5e\u665a\u671f\uff0c\u5e76\u6709\u5e74\u8f7b\u5316\u7684\u8d8b\u52bf\u3002\u6839\u636e\u56fd\u6cf0\u541b\u5b89\u7814\u62a5\uff0c\u665a\u671f\u80c3\u764c\u836f\u7269\u6cbb\u7597\u65b9\u5f0f\u4e3b\u8981\u4e3a\u5316\u7597\u548c HER2 \u9776\u5411\u7597\u6cd5\uff0c\u4f46\u662fHER2 \u5728\u80c3\u764c\u9633\u6027\u6bd4\u4f8b\u4ec5\u4e3a7~20%\uff08\u4e2d\u56fd\u80c3\u764c\u60a3\u8005 HER2\u9633\u6027\u738712~13%\uff09\uff0c\u8986\u76d6\u60a3\u8005\u4e0d\u591f\u5e7f\u6cdb\u3002\u867d\u7136\u4e00\u76f4\u4ee5\u6765\u80c3\u764c\u9886\u57df\u6709\u591a\u4e2a\u9776\u70b9\u5728\u7814\uff0c\u4f46\u662f\u8fd1\u5e74\u6765\u836f\u7269\u6cbb\u7597\u7684\u7a81\u7834\u4e5f\u8fd8\u662f\u4e3b\u8981\u96c6\u4e2d\u5728 PD-1 \u7c7b\u836f\u7269\u53caHER2 \u9776\u70b9\u836f\u7269\uff0c\u80c3\u764c\u6025\u9700\u51fa\u73b0\u65b0\u9776\u70b9\u7684\u7a81\u7834\uff0c\u6765\u5ef6\u957f\u73b0\u6709\u7684\u6cbb\u7597\u74f6\u9888\u3002<\/p>\n

\u79d1\u6d4e\u836f\u4e1a<\/span>\u5df2\u5411\u4e2d\u56fd\u56fd\u5bb6\u836f\u76d1\u5c40\u9012\u4ea4\u4e86\u542f\u52a8 CT041 \u5173\u952e II \u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7533\u8bf7\uff0c\u9884\u8ba1<\/span>\u516c\u53f8\u5c06\u5728 2022 \u5e74\u542f\u52a8\u7f8e\u56fd\u7684\u5173\u952eII\u671f\u4e34\u5e8a\u7814\u7a76\u3002<\/span><\/p>\n

\u76ee\u524d\u79d1\u6d4e\u836f\u4e1a\u5df2\u62e5\u670911\u6b3e\u5019\u9009\u4ea7\u54c1\uff0c\u5747\u4e3a\u81ea\u4e3b\u7814\u53d1\u4e14\u62e5\u6709\u5168\u7403\u6743\u76ca\uff0c\u6db5\u76d6\u5e38\u89c4\u578b\u3001\u65b0\u4e00\u4ee3CAR-T \u6280\u672f\u53ca\u540c\u79cd\u5f02\u4f53\u7597\u6cd5\uff0c\u5e03\u5c40\u5168\u9762\u4e14\u5bcc\u6709\u524d\u77bb\u6027\u3002\u79d1\u6d4e\u836f\u4e1a\u5df2\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u548c\u52a0\u62ff\u5927\u83b7\u5f977\u9879CAR-T\u7597\u6cd5\u7684IND\u8bb8\u53ef\uff0c\u5728\u4e2d\u56fd\u6240\u6709CAR-T\u516c\u53f8\u4e2d\u6392\u540d\u7b2c\u4e00\u3002<\/p>\n

\n

\"\u6765\u6e90\uff1a\u79d1\u6d4e\u836f\u4e1a2021\u5e74\u4e2d\u671f\u4e1a\u7ee9\u62a5\u544a\"<\/a>
\u6765\u6e90\uff1a\u79d1\u6d4e\u836f\u4e1a2021\u5e74\u4e2d\u671f\u4e1a\u7ee9\u62a5\u544a<\/span><\/p>\n<\/p><\/div>\n

\u6839\u636eNature Biotechnology\u6587\u7ae0\u6570\u636e\uff0c\u622a\u81f32019\u5e74\u5e95\uff0c\u6309\u7167CAR-T \u4e13\u5229\u603b\u6570\u7edf\u8ba1\uff0c\u5168\u7403\u6392\u540d\u524d20\u5bb6\u673a\u6784\u53ca\u516c\u53f8\u4e2d\uff0c\u79d1\u6d4e\u836f\u4e1a\u662f\u552f\u4e00\u4e00\u5bb6\u4e0a\u699c\u7684\u4e9a\u6d32\u516c\u53f8\u3002\u636e\u79d1\u6d4e\u836f\u4e1a2021\u5e74\u4e2d\u671f\u4e1a\u7ee9\u62a5\u544a\u62ab\u9732\uff0c\u622a\u81f32021\u5e748\u670815\u65e5\uff0c\u79d1\u6d4e\u836f\u4e1a\u5728\u8d85\u8fc719\u4e2a\u56fd\u5bb6\u6216\u5730\u533a\uff08\u5305\u62ec\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u6b27\u6d32\u53ca\u65e5\u672c\uff09\u62e5\u670952\u9879\u6388\u6743\u4e13\u5229\u53ca231\u9879\u4e13\u5229\u7533\u8bf7\u3002<\/span><\/p>\n

\n

\"\u6765\u6e90\uff1aNature<\/a>
\u6765\u6e90\uff1aNature Biotechnology<\/span><\/p>\n<\/p><\/div>\n

\u5728\u73b0\u6709\u4ea7\u54c1\u7ba1\u7ebf\u57fa\u7840\u4e4b\u4e0a\uff0c\u79d1\u6d4e\u5c06\u56f4\u7ed5\u201c\u5b9e\u4f53\u7624\u7597\u6548\u3001\u5b89\u5168\u6027\u3001\u60a3\u8005\u53ef\u53ca\u6027\u3001\u9776\u70b9\u53ef\u7528\u6027\u201d\u56db\u5927\u7814\u53d1\u6218\u7565\u65b9\u5411\uff0c\u6301\u7eed\u5f00\u53d1\u521b\u65b0\u4e13\u6709\u6280\u672f (CycloCAR, THANK-uCAR\u7b49)\uff0c\u4ee5\u89e3\u51b3CAR-T\u7597\u6cd5\u9886\u57df\u7684\u4e3b\u8981\u6311\u6218\u3002\u672a\u6765\uff0c\u8fd9\u4e9b\u6280\u672f\u5e73\u53f0\u4e5f\u5c06\u4e3a\u4e34\u5e8a\u9636\u6bb5\u6301\u7eed\u63d0\u4f9b\u66f4\u591a\u81ea\u4e3b\u7814\u53d1\u5019\u9009\u4ea7\u54c1\u3002<\/p>\n

\u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662\u526f\u9662\u957f\u3001\u6d88\u5316\u80bf\u7624\u5185\u79d1\u4e3b\u4efb\u3001\u2160\u671f\u4e34\u5e8a\u75c5\u533a\u4e3b\u4efb\u3001\u5317\u4eac\u5e02\u80bf\u7624\u9632\u6cbb\u7814\u7a76\u6240\u526f\u6240\u957f\u6c88\u7433\u6559\u6388\u8868\u793a<\/span>\uff1a\u80c3\u764c\u662f\u5168\u7403\u8303\u56f4\u9ad8\u53d1\u7684\u80bf\u7624\uff0c\u7279\u522b\u662f\u5728\u4e9a\u6d32\uff0c\u4e2d\u56fd\u7684\u80c3\u764c\u60a3\u8005\u7ea6\u5360\u5230\u5168\u7403\u80c3\u764c\u60a3\u8005\u6570\u91cf\u768450%\uff0c\u800c\u80c3\u764c\u603b\u4f53\u7684\u836f\u7269\u7814\u7a76\u548c\u6cbb\u7597\u624b\u6bb5\u4e0e\u5176\u4ed6\u7684\u5b9e\u4f53\u7624\u76f8\u6bd4\uff0c\u662f\u76f8\u5bf9\u6ede\u540e\u7684\uff0c\u5982\u4f55\u6539\u53d8\u73b0\u6709\u80c3\u764c\u6cbb\u7597\u7684\u56f0\u5883\uff0c\u4e00\u76f4\u662f\u5927\u5bb6\u975e\u5e38\u671f\u5f85\u7684\u3002<\/p>\n

\u8fd9\u6b21\u5728ESMO\u62a5\u9053\u7684\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u5728\u665a\u671f\u80c3\u764c\u6cbb\u7597\u4e2d\uff0cCT041\u5177\u6709\u663e\u8457\u7684\u7597\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u6211\u4eec\u671f\u5f85\u5b83\u80fd\u591f\u9020\u798f\u66f4\u591a\u7684\u764c\u75c7\u60a3\u8005\u3002<\/p>\n

\u79d1\u6d4e\u836f\u4e1a\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u4f1a\u4e3b\u5e2d\u3001<\/span>CEO\u3001CSO\u674e\u5b97\u6d77\u535a\u58eb\u8868\u793a\uff0c\u611f\u8c22\u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662\u9f50\u957f\u677e\u535a\u58eb\u4ee3\u8868\u7814\u7a76\u8005\u56e2\u961f\u5728ESMO\u5927\u4f1a\u4e0a\u4e0e\u4e1a\u754c\u5206\u4eabCT041\u7684\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff0c\u611f\u8c22\u6240\u6709\u7814\u7a76\u8005\u4e3a\u672c\u9879\u76ee\u7684\u503e\u529b\u4ed8\u51fa\u3002\u8fd9\u6837\u5177\u6709\u5f00\u521b\u6027\u7684\u5de5\u4f5c\u6ca1\u6709\u7814\u7a76\u8005\u7684\u503e\u529b\u4ed8\u51fa\u662f\u4e0d\u53ef\u80fd\u6709\u8fd9\u6837\u7684\u6210\u679c\u7684\u3002\u5f53\u7136\uff0c\u4e3a\u5168\u7403\u80c3\u764c\u7b49\u80bf\u7624\u60a3\u8005\u63d0\u4f9b\u66f4\u597d\u7684\u6cbb\u7597\u624b\u6bb5\u662f\u6211\u4eec\u6240\u6709\u4eba\u7684\u613f\u671b\uff0c\u4e5f\u503c\u5f97\u6211\u4eec\u4e3a\u4e4b\u594b\u6597\u3002<\/span><\/p>\n

\u5173\u4e8eCT041<\/p>\n

CT041\u662f\u79d1\u6d4e\u836f\u4e1a\u81ea\u4e3b\u5f00\u53d1\u7684\u4e00\u79cd\u6f5c\u5728\u5168\u7403\u540c\u7c7b\u9996\u521b\u7684\u3001\u9776\u5411CLDN18.2\u81ea\u4f53CAR-T\u5019\u9009\u4ea7\u54c1\uff0c\u7528\u4e8e\u6cbb\u7597CLDN18.2\u9633\u6027\u5b9e\u4f53\u7624\u5982\u80c3\u764c\/\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u764c\u53ca\u80f0\u817a\u764c\u3002\u79d1\u6d4e\u836f\u4e1a\u5728\u5168\u7403\u7387\u5148\u6210\u529f\u8bc6\u522b\u3001\u9a8c\u8bc1\u5e76\u62a5\u544aCLDN18.2\u53ef\u4f5c\u4e3a\u5b9e\u4f53\u7624CAR-T\u7684\u5408\u7406\u6cbb\u7597\u9776\u70b9\u3002\u9664\u4e86\u5728\u4e2d\u56fd\u7684\u7814\u7a76\u8005\u53d1\u8d77\u7684\u8bd5\u9a8c\u5916\uff0c\u79d1\u6d4e\u836f\u4e1a\u8fd8\u5728\u4e2d\u56fd\u542f\u52a8\u4e86\u9488\u5bf9\u665a\u671f\uff08\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\uff09\u80c3\u764c\/\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u764c\u548c\u80f0\u817a\u764c\u7684Ib\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5728\u7f8e\u56fd\u542f\u52a8\u4e86\u9488\u5bf9\u665a\u671f\uff08\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\uff09\u80c3\u764c\u6216\u80f0\u817a\u764c\u7684Ib\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n

\u5173\u4e8e\u79d1\u6d4e\u836f\u4e1a<\/p>\n

\u79d1\u6d4e\u836f\u4e1a\uff08\u80a1\u7968\u4ee3\u7801\uff1a2171.HK\uff09\u662f\u4e00\u5bb6\u5728\u4e2d\u56fd\u53ca\u7f8e\u56fd\u62e5\u6709\u4e1a\u52a1\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u6cbb\u7597\u8840\u6db2\u6076\u6027\u80bf\u7624\u548c\u5b9e\u4f53\u7624\u7684\u521b\u65b0CAR-T\u7ec6\u80de\u7597\u6cd5\u3002\u6211\u4eec\u5efa\u7acb\u4e86\u4e00\u4e2a\u7efc\u5408\u7ec6\u80de\u6cbb\u7597\u5e73\u53f0\uff0c\u5176\u5185\u90e8\u80fd\u529b\u6db5\u76d6\u4ece\u9776\u70b9\u53d1\u73b0\u3001\u6297\u4f53\u5f00\u53d1\u3001\u4e34\u5e8a\u8bd5\u9a8c\u5230\u5546\u4e1a\u89c4\u6a21\u751f\u4ea7\u3002\u6211\u4eec\u901a\u8fc7\u81ea\u4e3b\u7814\u53d1\u65b0\u6280\u672f\u4ee5\u53ca\u62e5\u6709\u5168\u7403\u6743\u76ca\u7684\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u4ee5\u89e3\u51b3CAR-T\u7ec6\u80de\u7597\u6cd5\u7684\u91cd\u5927\u6311\u6218\uff0c\u6bd4\u5982\u63d0\u9ad8\u5b89\u5168\u6027\uff0c\u63d0\u9ad8\u6cbb\u7597\u5b9e\u4f53\u7624\u7684\u7597\u6548\u548c\u964d\u4f4e\u6cbb\u7597\u6210\u672c\u3002\u6211\u4eec\u7684\u4f7f\u547d\u662f\u6210\u4e3a\u80fd\u4e3a\u5168\u7403\u764c\u75c7\u60a3\u8005\u5e26\u6765\u521b\u65b0\u548c\u5dee\u5f02\u5316\u7684\u7ec6\u80de\u7597\u6cd5\u5e76\u4f7f\u764c\u75c7\u53ef\u6cbb\u6108\u7684\u5168\u7403\u751f\u7269\u5236\u836f\u9886\u5bfc\u8005\u3002<\/p>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

ESMO\u53e3\u5934\u62a5\u544a \u4e0a\u6d772021\u5e749\u670820\u65e5 \/\u7f8e\u901a\u793e\/ — 2021\u5e749\u670819\u65e5\uff0c\u79d1\u6d4e\u836f\u4e1a\uff08\u80a1\u7968\u4ee3\u7801\uff1a2171.HK\uff09\u62ab\u9732Claudin18.2(CLDN18.2) CAR-T\uff08CT041\uff09\u6cbb\u7597\u6d88\u5316\u7cfb\u7edf\u80bf\u7624\u7684\u7814\u7a76\u8005\u53d1\u8d77\u8bd5\u9a8c\uff08IIT\uff09\u7684\u6700\u65b0\u8fdb\u5c55\uff0c\u8be5\u7814\u7a76\u7ed3\u679c\u5df2\u57282021\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\u5927\u4f1a\uff082021 ESMO\uff09\u8fdb\u884c\u53e3\u5934\u62a5\u544a\uff0c\u62a5\u544a\u4eba\u4e3a\u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662\u6c88\u7433\u6559\u6388\u56e2\u961f\u7684\u9f50\u957f\u677e\u535a\u58eb\u3002 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