{"id":44725,"date":"2021-09-17T09:08:00","date_gmt":"2021-09-17T02:08:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021091709080044725"},"modified":"2021-09-17T17:59:23","modified_gmt":"2021-09-17T09:59:23","slug":"%e6%9d%a5%e5%87%af%e5%8c%bb%e8%8d%af%e4%b8%a4%e9%a1%b9%e5%89%8d%e5%88%97%e8%85%ba%e7%99%8c%e6%b2%bb%e7%96%97%e7%9a%84%e4%b8%b4%e5%ba%8a%e7%a0%94%e7%a9%b6%e7%bb%93%e6%9e%9c%e4%bb%a4%e4%ba%ba%e6%8c%af","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021091709080044725","title":{"rendered":"\u6765\u51ef\u533b\u836f\u4e24\u9879\u524d\u5217\u817a\u764c\u6cbb\u7597\u7684\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u4ee4\u4eba\u632f\u594b"},"content":{"rendered":"<p><p><span class=\"xn-subheadline\">2021ESMO\u5e74\u4f1a\u5f00\u5e55<\/span><\/p>\n<p>\u4e0a\u6d77\u548c\u7f8e\u56fd\u65b0\u6cfd\u897f\u6c83\u4f262021\u5e749\u670817\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u5728\u4eca\u5929\u5f00\u5e55\u76842021\u5e74\u6b27\u6d32\u80bf\u7624\u533b\u5b66\u5b66\u4f1a\u5e74\u4f1a\uff08ESMO Congress\uff09\u4e0a\uff0c\u6765\u51ef\u533b\u836f\u53d1\u5e03\u4e86\u4e24\u9879\u5173\u4e8e\u524d\u5217\u817a\u764c\u6cbb\u7597\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u7ed3\u679c\u5747\u4ee4\u4eba\u632f\u594b\uff1a\u5176\u4e2d\u4e00\u9879\u662f\u9488\u5bf9\u65e9\u671f\u524d\u5217\u817a\u764c\u7684CYP17A1\u548cCYP11B2\u53cc\u9776\u70b9\u6291\u5236\u5242(LAE001)\u5355\u836f\u6cbb\u7597\uff0c\u53e6\u4e00\u9879\u662f&nbsp;LAE001 + afuresertib \u8054\u5408\u6cbb\u7597\u8010\u836f\u665a\u671f\u524d\u5217\u817a\u764c\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder4188\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/1627543\/20210916111149.html\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/20210916111149.jpg\" title=\"\u6765\u51ef\u533b\u836f\u9996\u6b21\u4eae\u76f8ESMO\" alt=\"\u6765\u51ef\u533b\u836f\u9996\u6b21\u4eae\u76f8ESMO\" \/><\/a><br \/><span>\u6765\u51ef\u533b\u836f\u9996\u6b21\u4eae\u76f8ESMO<\/span><\/p>\n<\/p><\/div>\n<p><b>\u4e24\u9879\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u79ef\u6781<\/b><\/p>\n<p><b>\u7535\u5b50\u58c1\u62a5<\/b><b>597P<br \/><\/b><b>CYP17A1<\/b><b>\u548c<\/b><b>CYP11B2<\/b><b>\u53cc\u9776\u70b9\u6291\u5236\u5242<\/b><b>(LAE001)<\/b><b>\uff0c\u5728\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u578b\u524d\u5217\u817a<\/b><b>(mCRPC)<\/b><b>\u764c\u60a3\u8005\u4e2d\u7684<\/b><b>&nbsp;I <\/b><b>\u671f\u7814\u7a76<\/b><\/p>\n<p><b>\u4e3b\u8981\u7814\u7a76\u8005\u53ca\u62a5\u544a\u4eba\uff1a<\/b>\u53f6\u5b9a\u4f1f\u6559\u6388\uff08\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\uff09<br \/>\u8fd9\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u3001Ia\/Ib\u671f\u4e24\u9636\u6bb5\u7814\u7a76\uff0c\u7528\u4e8e\u63a2\u7d22\u5728\u4e0d\u8054\u7528\u6cfc\u5c3c\u677e\u7684\u60c5\u51b5\u4e0b\uff0cLAE001\u5355\u836f\u5728\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u836f\u4ee3\u5b66\u7279\u70b9\u548c\u521d\u6b65\u7597\u6548\u3002LAE001\u662f\u5168\u7403\u9996\u4e2a&nbsp;CYP17A1\u548cCYP11B2\u53cc\u9776\u70b9\u6291\u5236\u5242\u3002<\/p>\n<p><b>\u521d\u6b65\u7ed3\u679c\u663e\u793a<\/b>\uff08\u622a\u81f32021\u5e745\u670825\u65e5\uff09\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u5728\u63a5\u53d750\u6beb\u514b\u6cbb\u7597\u768415\u4f8b\u60a3\u8005\u4e2d\uff0c11 \u540d\u60a3\u8005\uff0873%\uff09\u7684&nbsp;PSA \u6bd4\u57fa\u7ebf\u4e0b\u964d&nbsp;&gt;50%\uff0c\u5176\u4e2d&nbsp;6 \u540d\u60a3\u8005\uff0840%\uff09\u7684&nbsp;PSA \u6bd4\u57fa\u7ebf\u4e0b\u964d&nbsp;&gt;90% <\/li>\n<li>2 \u540d\u60a3\u8005\uff0850 \u6beb\u514b&nbsp;BID\u7ec4\uff09\u7684&nbsp;PSA \u53cd\u5e94\u6301\u7eed&nbsp;&gt; 52 \u5468\u300281%\u7684PSA\u5206\u6790\u60a3\u8005\u4ecd\u5728\u63a5\u53d7\u6cbb\u7597<\/li>\n<\/ul>\n<p><b>\u7ed3\u8bba<\/b>\uff1a\u5728II\u671f\u63a8\u8350\u5242\u91cf&nbsp;\u6bcf\u59292\u6b2150mg\u7ed9\u836f\u60c5\u51b5\u4e0b\uff0cLAE001 \u5355\u4e00\u7597\u6cd5\u5b89\u5168\u4e14\u8010\u53d7\u826f\u597d\uff0c\u521d\u6b65\u6297\u80bf\u7624\u6d3b\u6027\u652f\u6301\u6cbb\u7597&nbsp;mCRPC \u60a3\u8005\u7684\u6f5c\u5728\u4e34\u5e8a\u76ca\u5904\u3002&nbsp;\u76ee\u524dII\u671f\u63a8\u8350\u5242\u91cf\u7684\u8fdb\u4e00\u6b65Ib\u671f\u548cII\u671f\u4e34\u5e8a\u7814\u7a76<sup>[1]<\/sup>\u6b63\u5728<span id=\"spanHghlt6e78\">\u8fdb\u884c\u4e2d\u3002<\/span><\/p>\n<p><b>\u7535\u5b50\u58c1\u62a5<\/b><b>599P<br \/><\/b><b>LAE001\/<\/b><b>\u6cfc\u5c3c\u677e<\/b><b>+ afuresertib (<\/b><b>\u4e00\u79cd<\/b><b>AKT<\/b><b>\u6291\u5236\u5242<\/b><b>)&nbsp;<\/b><b>\u8054\u5408\uff0c\u5728\u7ecf\u6807\u51c6\u6cbb\u7597\u540e\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u578b\u524d\u5217\u817a\u764c<\/b><b>(mCRPC)\u60a3\u8005\u4e2d\u7684<\/b><b>I<\/b><b>\u671f\u7814\u7a76<\/b><\/p>\n<p><b>\u4e3b\u8981\u7814\u7a76\u8005\u53ca\u62a5\u544a\u4eba\uff1a<\/b><span class=\"xn-person\">Alberto Bessudo<\/span> (<span class=\"xn-location\">Encinitas, CA<\/span>, <span class=\"xn-location\">United States of America<\/span>)<br \/>\u6b64\u9879I\/II\u671f\u4e24\u9636\u6bb5\u7814\u7a76\u7684I\u671f\u90e8\u5206\u4e3a\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u3001\u5242\u91cf\u9012\u589e\u7814\u7a76\uff0c\u9002\u7528\u4e8e\u5148\u524d\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u79cd\u4e8c\u4ee3\u6297\u96c4\u6fc0\u7d20\u548c\/\u6216\u5316\u7597\u8fd92\u79cd\u6807\u51c6\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u8010\u53d7\u7684mCRPC\u60a3\u8005\uff0c\u65e8\u5728\u8bc4\u4f30\u5b89\u5168\u6027\u5e76\u786e\u5b9aII\u671f\u7814\u7a76\u4e2d&nbsp;LAE001\/\u6cfc\u5c3c\u677e\u548c&nbsp;afuresertib&nbsp;\u8054\u5408\u6cbb\u7597\u76842&nbsp;\u671f\u63a8\u8350&nbsp;\u5242\u91cf&nbsp;(RP2D)\u3002<br \/>Afuresertib\uff08LAE002\uff09\u662f\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\u76841\u7c7b\u5019\u9009\u65b0\u836f\uff0c\u5c5e\u4e8e\u65b0\u4e00\u4ee3\u5c0f\u5206\u5b50\u6cdbAKT\u6fc0\u9176\u5f3a\u6548\u6291\u5236\uff1bLAE001\u662f\u5168\u7403\u9996\u4e2aCYP17A1\u548cCYP11B2\u53cc\u9776\u70b9\u6291\u5236\u5242\u3002<\/p>\n<p><b>\u521d\u6b65\u7ed3\u679c\u663e\u793a<\/b>\uff08\u622a\u81f32021\u5e746\u670829\u65e5\uff09<b>\uff1a<\/b><b>&nbsp;<\/b><\/p>\n<ul type=\"disc\">\n<li>\u5728\u63a5\u53d7\u6cbb\u7597\u768414\u4f8b\u60a3\u8005\u4e2d\uff0c2\u4f8b\u6709\u8f83\u57fa\u7ebf\u964d\u4f4e\u8d85\u8fc750% \u7684PSA\u7f13\u89e3 <\/li>\n<li>5\u4f8b\u6709\u57fa\u7ebf\u53ef\u6d4b\u91cf\u75c5\u7076\u7684\u60a3\u8005\u4e2d\u89c2\u5bdf\u52301\u4f8b\u6709\u7f13\u89e3\u548c2\u4f8b\u75be\u75c5\u7a33\u5b9a <\/li>\n<li>10\u4f8b\u53ef\u8bc4\u4f30\u60a3\u8005\u5e73\u5747\u5df2\u7ecf\u57283\u7ebf\u65e2\u5f80\u6cbb\u7597\u4e2d\u5931\u8d25<\/li>\n<\/ul>\n<p><b>\u7ed3\u8bba\uff1a<br \/><\/b>II\u671f\u63a8\u8350\u5242\u91cf\u4e3aLAE001 75mg \/\u6cfc\u5c3c\u677e 5mg \u548c afuresertib 125mg \u7684\u8054\u5408\u6cbb\u7597\uff0c\u521d\u6b65\u6297\u80bf\u7624\u6d3b\u6027\u652f\u6301\u6cbb\u7597 dr-mCRPC \u7684\u6f5c\u5728\u4e34\u5e8a\u76ca\u5904\uff0c\u5e76\u63a8\u8fdb\u5230 II \u671f\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\u3002<\/p>\n<p><b>\u671f\u5f85\u521b\u65b0\u836f\u7269\u5c3d\u65e9\u60e0\u53ca\u524d\u5217\u817a\u764c\u60a3\u8005<\/b><\/p>\n<p>\u201c\u4f5c\u4e3a\u4e00\u5bb6\u533b\u836f\u65b0\u9510\uff0c\u8fd9\u662f\u6765\u51ef\u533b\u836f\u9996\u6b21\u4eae\u76f8ESMO\u5e74\u4f1a\uff0c\u6211\u4eec\u5f88\u9ad8\u5174\u540c\u65f6\u6709\u4e24\u9879\u4e34\u5e8a\u7814\u7a76\u5f97\u5230\u4e86\u8fd9\u4e00\u56fd\u9645\u6743\u5a01\u5b66\u672f\u4f1a\u8bae\u7684\u8ba4\u53ef\u3002\u201d\u6765\u51ef\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98\u5cb3\u52c7\u535a\u58eb\u8868\u793a\u3002<\/p>\n<p>\u524d\u5217\u817a\u764c\u662f\u5168\u7403\u7537\u6027\u53d1\u75c5\u7387\u6700\u9ad8\u7684\u764c\u75c7\uff0c\u4e5f\u662f\u4e2d\u56fd\u53d1\u75c5\u7387\u7b2c7\u4f4d\u7684\u764c\u75c7\u3002\u7b2c\u4e00\u4e2a\u7814\u7a76\u9879\u76ee\u4e2d\uff0c\u5728\u672a\u4e0e\u6ce2\u5c3c\u677e\u8054\u7528\u7684\u60c5\u51b5\u4e0b\uff0cLAE001\u5355\u836f\u4ecd\u8868\u73b0\u51fa\u60a3\u8005\u53ef\u8010\u53d7\u7684\u5b89\u5168\u6027\u548c\u8f83\u5f3a\u7684\u6297\u80bf\u7624\u529f\u6548\u3002\u6765\u51ef\u533b\u836f\u6b63\u5feb\u901f\u63a8\u8fdb\u8fd9\u4e00\u4e34\u5e8a\u7814\u7a76\u9879\u76ee\uff0c\u5bf9\u9700\u8981\u957f\u671f\u6cbb\u7597\u7684\u524d\u5217\u817a\u764c\u60a3\u8005\u800c\u8a00\uff0c\u6709\u671b\u5f88\u5927\u7a0b\u5ea6\u907f\u514d\u73b0\u6709\u6cbb\u7597\u6807\u51c6\u4e2d\u5bf9\u6cfc\u5c3c\u677e\u7684\u4f9d\u8d56\u53ca\u5176\u5f15\u53d1\u7684\u526f\u4f5c\u7528\u548c\u5bf9\u60a3\u8005\u751f\u5b58\u8d28\u91cf\u7684\u5f71\u54cd\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u4ea7\u751f\u6297\u836f\u6027\u7684\u665a\u671f\u524d\u5217\u817a\u764c\u662f\u6700\u96be\u6cbb\u7684\u764c\u75c7\u4e4b\u4e00\uff0c\u60a3\u8005\u4e9f\u9700\u66f4\u6709\u6548\u7684\u521b\u65b0\u836f\u7269\u548c\u7597\u6cd5\u3002\u6765\u51ef\u533b\u836f\u7b2c\u4e8c\u9879\u7814\u7a76\u4e2d\u5c55\u793a\u7684LAE001\u4e0eafuresertib\u7684\u8054\u5408\u6cbb\u7597\uff0c\u6709\u671b\u4f7fPTEN\/PIK3CA\/AKT \u7f3a\u5931\u7684\u60a3\u8005\u53d7\u76ca\u3002<\/p>\n<p>\u5cb3\u52c7\u535a\u58eb\u8868\u793a<span id=\"spanHghlt1594\">\uff0c<\/span>\u6b64\u6b21\u6765\u51ef\u533b\u836f\u5728ESMO\u5927\u4f1a\u4e0a\u5206\u4eab\u7684\u9876\u7ebf\u6570\u636e\uff0c\u662f\u516c\u53f8\u4e24\u4e2a\u5728\u7814\u7684\u6838\u5fc3\u521b\u65b0\u836f\u7269 &#8212; \u5168\u7403\u9996\u4e2aCYP17A1\u548cCYP11B2\u53cc\u9776\u70b9\u6291\u5236\u5242\u548c\u65b0\u4e00\u4ee3\u5c0f\u5206\u5b50\u6cdbAKT\u6fc0\u9176\u5f3a\u6548\u6291\u5236\u5242afuresertib\uff0c\u5728\u56fd\u9645\u9876\u7ea7\u5b66\u672f\u4f1a\u8bae\u4e0a\u7684\u4e00\u6b21\u91cd\u8981\u8fdb\u5c55\u6c47\u62a5\u3002\u201c\u968f\u7740\u4e0a\u8ff0\u4e24\u4e2a\u7814\u7a76\u7684\u63a8\u8fdb\uff0c\u8fd1\u4e09\u4e2a\u6708\u6211\u4eec\u5df2\u7ecf\u5728\u5165\u7ec4\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u66f4\u9f13\u821e\u4eba\u5fc3\u7684\u7ed3\u679c\uff0c\u671f\u5f85\u8fd9\u4e9b\u5019\u9009\u836f\u7269\u80fd\u591f\u5c3d\u65e9\u60e0\u53ca\u65e9\u671f\u548c\u665a\u671f\u7684\u524d\u5217\u817a\u764c\u60a3\u8005\u3002\u201d&nbsp;<\/p>\n<div>\n<table id=\"convertedTable7c30\" cellspacing=\"0\" cellpadding=\"0\" border=\"1\" class=\"prntblns\">\n<tbody>\n<tr>\n<td class=\"prnsbt1 prnsbr1 prnvab prnsbb1 prnpl6 prnsbl1 prnpr6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[1] 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