{"id":44020,"date":"2021-09-13T05:05:00","date_gmt":"2021-09-12T22:05:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021091305050044020"},"modified":"2021-09-13T17:55:27","modified_gmt":"2021-09-13T09:55:27","slug":"%e7%99%be%e6%b5%8e%e7%a5%9e%e5%b7%9e%e5%b0%86%e5%9c%a82021%e5%b9%b4esmo%e5%b9%b4%e4%bc%9a%e4%b8%8a%e5%b1%95%e7%a4%ba%e5%85%b6%e5%9c%a8%e8%82%ba%e7%99%8c%e6%b2%bb%e7%96%97%e9%a2%86%e5%9f%9f%e4%b8%b0","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021091305050044020","title":{"rendered":"\u767e\u6d4e\u795e\u5dde\u5c06\u57282021\u5e74ESMO\u5e74\u4f1a\u4e0a\u5c55\u793a\u5176\u5728\u80ba\u764c\u6cbb\u7597\u9886\u57df\u4e30\u5bcc\u4ea7\u54c1\u7ebf\u7684\u6700\u65b0\u7814\u7a76\u6210\u679c"},"content":{"rendered":"

\u4e2d\u56fd\u5317\u4eac\u548c\u7f8e\u56fd\u9ebb\u7701\u5251\u68652021\u5e749\u670813\u65e5 \/\u7f8e\u901a\u793e\/ — \u767e\u6d4e\u795e\u5dde<\/a>\uff08\u7eb3\u65af\u8fbe\u514b\u4ee3\u7801\uff1aBGNE\uff1b\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a06160\uff09\u662f\u4e00\u5bb6\u5168\u7403\u6027\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5728\u4e16\u754c\u8303\u56f4\u5185\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u521b\u65b0\u836f\u7269\u3002\u516c\u53f8\u4e8e\u4eca\u65e5\u5ba3\u5e03\uff0c\u5c06\u57282021\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\uff08ESMO\uff09\u5e74\u4f1a\u4e0a\u5c55\u793a\u5176\u5728\u80ba\u764c\u6cbb\u7597\u9886\u57df\u4e30\u5bcc\u4ea7\u54c1\u7ebf\u7684\u4e34\u5e8a\u7ed3\u679c\u548c\u4e9a\u7ec4\u5206\u6790\u60c5\u51b5\u3002 <\/p>\n

\u767e\u6d4e\u795e\u5dde\u514d\u75ab\u80bf\u7624\u5b66\u9996\u5e2d\u533b\u5b66\u5b98\u8d32\u52c7\u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a\u201c\u501f\u52a9\u516c\u53f8\u4e30\u5bcc\u7684\u514d\u75ab\u80bf\u7624\u4ea7\u54c1\u7ebf\uff0c\u6211\u4eec\u6301\u7eed\u53d6\u5f97\u4e86\u5177\u6709\u91cd\u8981\u610f\u4e49\u7684\u7814\u7a76\u8fdb\u5c55\uff0c\u5176\u4e2d\u5305\u62ec\u6b63\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u9886\u57df\u5f00\u5c55\u7684\u4e03\u98793\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u968f\u7740\u5bf9\u836f\u7269\u4e34\u5e8a\u4f5c\u7528\u7406\u89e3\u7684\u4e0d\u65ad\u52a0\u6df1\uff0c\u6211\u4eec\u6b63\u5728\u52a0\u901f\u767e\u6cfd\u5b89®<\/sup>\u5728\u80ba\u764c\u9886\u57df\u7684\u65b0\u578b\u8054\u5408\u7597\u6cd5\u7684\u5f00\u53d1\u8fdb\u7a0b\uff0c\u5305\u62ec\u4e0e\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684\u5728\u7814\u5f3a\u6548\u6297TIGIT\u6297\u4f53ociperlimab\uff0c\u4ee5\u53ca\u4e0e\u5916\u90e8\u5408\u4f5c\u5f00\u53d1\u7684\u5728\u7814\u836f\u7269\uff0c\u5982sitravatinib\u7684\u8054\u5408\u7597\u6cd5\u3002\u6b64\u5916\uff0c\u6211\u4eec\u7684\u79d1\u5b66\u5bb6\u6b63\u5728\u63a2\u7d22\u767e\u6cfd\u5b89®<\/sup>\u5728\u80ba\u764c\u548c\u5176\u4ed6\u5b9e\u4f53\u7624\u9886\u57df\u65b0\u7684\u8054\u5408\u7528\u836f\u6a21\u5f0f\u3002\u540c\u65f6\uff0c\u4f34\u968f\u7740\u4e0e\u8bfa\u534e\u7684\u5408\u4f5c\u63a8\u8fdb\uff0c\u767e\u6cfd\u5b89®<\/sup>\u80fd\u591f\u501f\u52a9\u8bfa\u534e\u5728\u80bf\u7624\u836f\u7269\u7ba1\u7ebf\u4e0a\u7684\u4f18\u52bf\uff0c\u63a2\u7d22\u66f4\u591a\u8054\u5408\u7597\u6cd5\u7684\u53ef\u80fd\u6027\u3002\u6211\u4eec\u671f\u5f85\u901a\u8fc7\u5bf9\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\u60a3\u8005\u5f00\u5c55\u7684\u8054\u5408\u6cbb\u7597\u63a2\u7d22\uff0c\u53d1\u6398\u8fd9\u6b3e\u5dee\u5f02\u5316\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u6cbb\u7597\u6f5c\u529b\uff0c\u60e0\u53ca\u66f4\u591a\u5168\u7403\u60a3\u8005\u3002\u201d<\/p>\n

\u6b32\u4e86\u89e3\u66f4\u591a\u5173\u4e8e\u767e\u6d4e\u795e\u5dde\u7814\u53d1\u548cESMO\u5e74\u4f1a\u76f8\u5173\u6d3b\u52a8\u7684\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95eehttps:\/\/beigenemedical.eu\/<\/a>\u3002 <\/p>\n

\u767e\u6cfd\u5b89<\/b>®<\/sup><\/b>\u5728\u80ba\u764c\u9886\u57df\u5f00\u5c55\u7684\u5e7f\u6cdb\u8054\u5408\u6cbb\u7597\u7814\u7a76\u9879\u76ee<\/b><\/p>\n

\u767e\u6d4e\u795e\u5dde\u6b63\u5728\u52aa\u529b\u63a2\u7d22\u767e\u6cfd\u5b89®<\/sup>\u8054\u5408\u7528\u836f\u7684\u591a\u79cd\u4f5c\u7528\u673a\u5236\uff0c\u5b8c\u5584PD-1\u901a\u8def\u7684\u9776\u5411\u4f5c\u7528\uff0c\u4ee5\u671f\u6539\u5584\u4e34\u5e8a\u6548\u679c\u6216\u514b\u670d\u4e0e\u75be\u75c5\u8fdb\u5c55\u76f8\u5173\u7684\u8010\u836f\u6027\u3002 <\/p>\n

\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u6cbb\u7597\u4e2d\uff0c\u8bb8\u591a\u66fe\u63a5\u53d7\u524d\u7ebf\u6297PD-1\u6297\u4f53\u6cbb\u7597\u540e\u5f97\u5230\u7f13\u89e3\u7684\u60a3\u8005\u6700\u7ec8\u56e0\u8010\u836f\u800c\u590d\u53d1\u3002\u901a\u8fc7\u4e0eMirati Therapeutics\u516c\u53f8\u5408\u4f5c\uff0c\u767e\u6d4e\u795e\u5dde\u6b63\u5728\u7814\u7a76\u767e\u6cfd\u5b89®<\/sup>\u4e0esitravatinib\u7684\u8054\u5408\u7597\u6cd5\uff0csitravatinib\u662f\u4e00\u79cd\u6709\u671b\u901a\u8fc7\u9006\u8f6c\u514d\u75ab\u6291\u5236\u80bf\u7624\u5fae\u73af\u5883\uff0c\u4ee5\u514b\u670d\u514d\u75ab\u8010\u53d7\u7684\u5e7f\u8c31\u9009\u62e9\u6027\u7684\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u3002\u767e\u6d4e\u795e\u5dde\u6b63\u5728\u5f00\u5c55\u8be5\u65b0\u578b\u8054\u5408\u6cbb\u7597\u65b9\u6848\u5728NSCLC\u9886\u57df\u76843\u671f\u8bd5\u9a8c\uff0c\u5e76\u5c06\u57282021\u5e74ESMO\u5e74\u4f1a\u4e0a\u5c55\u793a\u5176\u6b63\u5728\u8fdb\u884c\u7684\u5bf9\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\uff08\u5305\u62ec\u521d\u6cbb\u548c\u96be\u6cbb\u6027\u6216\u5bf9\u4e8e\u6297PD-(L)1\u6cbb\u7597\u8010\u836f\u7684\u60a3\u8005\uff09\u76841b\u671f\u8bd5\u9a8c\u7684\u4e34\u5e8a\u7ed3\u679c\u3002<\/p>\n

\u767e\u6d4e\u795e\u5dde\u5728\u80ba\u764c\u9886\u57df\u5f00\u5c55\u7684\u53e6\u4e00\u9879\u521b\u65b0\u8054\u5408\u7597\u6cd5\u7814\u7a76\u662f\u767e\u6cfd\u5b89®<\/sup>\u4e0eociperlimab\u7684\u7ec4\u5408\u3002Ociperlimab\u662f\u4e00\u6b3e\u5f3a\u6548\u3001\u5177\u6709\u5b8c\u6574Fc\u6bb5\u529f\u80fd\u7684\u5728\u7814\u6297TIGIT\u6297\u4f53\uff0c\u76ee\u524d\u8be5\u8054\u5408\u7597\u6cd5\u6b63\u5904\u4e8e3\u671f\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u3002TIGIT\u662f\u4e00\u79cd\u5171\u6291\u5236\u6027\u514d\u75ab\u68c0\u67e5\u70b9\u53d7\u4f53\uff0c\u8868\u8fbe\u4e8e\u591a\u79cd\u514d\u75ab\u7ec6\u80de\u3002\u6700\u8fd1\u53d1\u73b0\uff0cTIGIT\u53ef\u4f5c\u4e3a\u65b0\u7684\u6cbb\u7597\u9776\u70b9\uff0c\u4e0ePD-1\u8054\u5408\u6709\u53ef\u80fd\u8fdb\u4e00\u6b65\u6291\u5236\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u3002\u767e\u6cfd\u5b89®<\/sup>\u5728\u80ba\u764c\u9886\u57df\u7684\u5e7f\u6cdb\u8054\u5408\u7597\u6cd5\u8fd8\u5305\u62ec\u4e0ePI3K\u03b4\u6291\u5236\u5242BGB-10188\u3001\u6297TIM-3\u6297\u4f53BGB-A425\u548c\u5316\u7597\u7684\u8054\u5408\u3002<\/p>\n

\u4ee5\u5353\u8d8a\u79d1\u7814\u5b9e\u529b\u548c\u4e34\u5e8a\u6d1e\u5bdf\u4e3a\u9a71\u52a8\uff0c\u6301\u7eed\u62d3\u5c55<\/b>NSCLC<\/b>\u9886\u57df\u7684\u5f00\u53d1<\/b><\/p>\n

\u8fd1\u5e74\u6765\uff0c\u5168\u7403\u5728NSCLC\u9886\u57df\u7684\u6cbb\u7597\u624b\u6bb5\u867d\u53d6\u5f97\u4e86\u4e00\u5b9a\u8fdb\u5c55\uff0c\u4f46\u4f5c\u4e3a\u4e00\u9879\u9ad8\u53d1\u7684\u764c\u75c7\u7c7b\u578b\uff0c\u5728\u4e34\u5e8a\u6cbb\u7597\u4e0a\u4ecd\u5b58\u5728\u5927\u91cf\u5c1a\u672a\u88ab\u6ee1\u8db3\u7684\u6cbb\u7597\u9700\u6c42\u3002\u767e\u6d4e\u795e\u5dde\u76ee\u524d\u6b63\u5728\u4e00\u9879\u7efc\u5408\u6027NSCLC\u9879\u76ee\u4e2d\u8bc4\u4f30\u767e\u6cfd\u5b89®<\/sup>\u7684\u8868\u73b0\uff0c\u8be5\u9879\u76ee\u5305\u62ec10\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6db5\u76d6\u4e86\u4ece\u65e9\u671f\u5230\u540e\u7ebf\u7684\u60a3\u8005\u3002 <\/p>\n

\u4e3a\u4e86\u6df1\u5165\u63a2\u7d22\u4e0d\u540c\u60a3\u8005\u7279\u5f81\u5bf9\u6cbb\u7597\u7ed3\u679c\u7684\u5f71\u54cd\uff0c\u767e\u6d4e\u795e\u5dde\u7684\u514d\u75ab\u80bf\u7624\u5b66\u56e2\u961f\u4ece\u5730\u57df\u3001\u75be\u75c5\u5206\u671f\u3001\u5438\u70df\u72b6\u51b5\uff0c\u4ee5\u53ca\u751f\u7269\u6807\u5fd7\u7269\u7684\u4f7f\u7528\u7b49\u65b9\u9762\u5206\u6790\u4e86NSCLC\u8bd5\u9a8c\u7684\u4e34\u5e8a\u7ed3\u679c\u3002 <\/p>\n

\u767e\u6d4e\u795e\u5dde\u6700\u8fd1\u57282021\u5e74\u4e16\u754c\u80ba\u764c\u5927\u4f1a\uff08WCLC\uff09\u4e0a\u5c55\u793a\u4e86RATIONALE 307\u8bd5\u9a8c\u4e9a\u7ec4\u5206\u6790\u7684\u7ed3\u679c\u3002\u8be5\u4e9a\u7ec4\u5206\u6790\u8868\u660e\u4e0d\u8bbaPD-L1\u8868\u8fbe\u3001\u8840\u6db2\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff08TMB\uff09\u3001\u7ec4\u7ec7TMB\u548c\u75be\u75c5\u5206\u671f\uff08IIIB\u6216IV\u671f\uff09\u5982\u4f55\uff0c\u767e\u6cfd\u5b89®<\/sup>\u8054\u5408\u5316\u7597\u5728\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u521d\u6cbb\u60a3\u8005\u4e2d\u5c55\u793a\u4e86\u4e00\u81f4\u7684\u751f\u5b58\u83b7\u76ca\u3002 <\/p>\n

\u57282021\u5e74ESMO\u5e74\u4f1a\u4e0a\uff0c\u767e\u6d4e\u795e\u5dde\u8fd8\u5c06\u62a5\u544aRATIONALE 304\u548cRATIONALE 307\u4e24\u9879\u4e00\u7ebfNSCLC\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5438\u70df\u8005\u4e0e\u4e0d\u5438\u70df\u60a3\u8005\u7684\u989d\u5916\u5206\u6790\u7ed3\u679c\u3002<\/p>\n

\u6b64\u5916\uff0c\u767e\u6d4e\u795e\u5dde\u6b63\u5728\u63a2\u7d22\u767e\u6cfd\u5b89®<\/sup>\u4f5c\u4e3a\u65e9\u671f\u6cbb\u7597\u9009\u62e9\u7684\u6f5c\u529b\uff0c\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u5168\u74033\u671f\u8bd5\u9a8cRATIONALE 315\u4ee5\u63a2\u7d22\u767e\u6cfd\u5b89®<\/sup>\u5728\u65b0\u8f85\u52a9\u6216\u8f85\u52a9\u6cbb\u7597\u9886\u57df\u7684\u5e94\u7528\u3002<\/p>\n

\u767e\u6d4e\u795e\u5dde\u5728<\/b>2021<\/b>\u5e74<\/b>ESMO<\/b>\u5e74\u4f1a\u4e0a\u5c55\u793a\u7684\u7535\u5b50\u6d77\u62a5<\/b><\/p>\n

\n\n\n\n\n\n\n\n\n\n
\n

\u6458\u8981\u7f16\u53f7<\/b><\/span><\/p>\n<\/td>\n

\n

\u6807\u9898<\/b><\/span><\/p>\n<\/td>\n

\n

\u4e3b\u8981\u4f5c\u8005<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

3649<\/span><\/p>\n<\/td>\n

\n

Sitravatinib\u8054\u5408\u66ff\u96f7\u5229\u73e0\u5355\u6297\u7528\u4e8e\u6cbb\u7597\u5bf9\u4e8e\u6297PD-(L)1\u96be\u6cbb\/\u8010\u836f\u7684\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005<\/span><\/p>\n<\/td>\n

\n

\u9ad8\u535a\uff0c\u533b\u5b66\u535a\u58eb\uff0c\u535a\u58eb<\/span><\/p>\n

Blacktown\u764c\u75c7\u548c\u8840\u6db2\u5b66\u4e2d\u5fc3
\uff08\u6fb3\u5927\u5229\u4e9a\uff09<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

3457<\/span><\/p>\n<\/td>\n

\n

Sitravatinib\u8054\u5408\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6cbb\u7597\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005<\/span><\/p>\n<\/td>\n

\n

\u5468\u6e05\uff0c\u533b\u5b66\u535a\u58eb\uff0c\u535a\u58eb<\/span><\/p>\n

\u5e7f\u4e1c\u7701\u4eba\u6c11\u533b\u9662\uff08\u4e2d\u56fd\uff09<\/span><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

2562<\/span><\/p>\n<\/td>\n

\n

\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5355\u836f\u6cbb\u7597\u540e\u5bf9\u7ecf\u6cbb\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c\u60a3\u8005\u5065\u5eb7\u76f8\u5173\u751f\u6d3b\u8d28\u91cf\u7684\u5f71\u54cd<\/span><\/p>\n<\/td>\n

\n

\u4efb\u6b63\u521a\uff0c\u533b\u5b66\u535a\u58eb\uff0c\u535a\u58eb<\/span><\/p>\n

\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u4e2d\u5c71\u533b\u9662\uff08\u4e2d\u56fd\uff09<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

3786<\/span><\/p>\n<\/td>\n

\n

RATIONALE 304\uff1a\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u5bf9\u6bd4\u5355\u72ec\u5316\u7597\u4f5c\u4e3a\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u5438\u70df\u8005\u4e0e\u4e0d\u5438\u70df\u8005\u7684\u4e00\u7ebf\u6cbb\u7597<\/span><\/p>\n<\/td>\n

\n

\u9646\u821c\uff0c\u533b\u5b66\u535a\u58eb<\/span><\/p>\n

\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u9644\u5c5e\u80f8\u79d1\u533b\u9662<\/span><\/span><\/p>\n

\uff08\u4e2d\u56fd\uff09<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

4053<\/span><\/p>\n<\/td>\n

\n

\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u5bf9\u6bd4\u5355\u72ec\u5316\u7597\u4f5c\u4e3a\u665a\u671f\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u5438\u70df\u8005\u4e0e\u4e0d\u5438\u70df\u8005\u7684\u4e00\u7ebf\u6cbb\u7597<\/span><\/p>\n<\/td>\n

\n

\u4f59\u65b0\u6c11\uff0c\u533b\u5b66\u535a\u58eb<\/span><\/p>\n

\u4e2d\u56fd\u79d1\u5b66\u9662\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662<\/span><\/span><\/p>\n

\uff08\u4e2d\u56fd\uff09<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

1587<\/span><\/p>\n<\/td>\n

\n

\u6297\u751f\u7d20\u7684\u4f7f\u7528\u4e0e\u66ff\u96f7\u5229\u73e0\u5355\u6297\u5355\u836f\u6cbb\u7597\u4e34\u5e8a\u7ed3\u679c\u95f4\u7684\u5173\u8054\u6027<\/span><\/p>\n<\/td>\n

\n

\u4efb\u6b63\u521a\uff0c\u533b\u5b66\u535a\u58eb\uff0c\u535a\u58eb<\/span><\/p>\n

\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u4e2d\u5c71\u533b\u9662\uff08\u4e2d\u56fd\uff09<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n","protected":false},"excerpt":{"rendered":"

\u4e2d\u56fd\u5317\u4eac\u548c\u7f8e\u56fd\u9ebb\u7701\u5251\u68652021\u5e749\u670813\u65e5 \/\u7f8e\u901a\u793e\/ — \u767e\u6d4e\u795e\u5dde\uff08\u7eb3\u65af\u8fbe\u514b\u4ee3\u7801\uff1aBGNE\uff1b\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a06160\uff09\u662f\u4e00\u5bb6\u5168\u7403\u6027\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5728\u4e16\u754c\u8303\u56f4\u5185\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u521b\u65b0\u836f\u7269\u3002\u516c\u53f8\u4e8e\u4eca\u65e5\u5ba3\u5e03\uff0c\u5c06\u57282021\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\uff08ESMO\uff09\u5e74\u4f1a\u4e0a\u5c55\u793a\u5176\u5728\u80ba\u764c\u6cbb\u7597\u9886\u57df\u4e30\u5bcc\u4ea7\u54c1\u7ebf\u7684\u4e34\u5e8a\u7ed3\u679c\u548c\u4e9a\u7ec4\u5206\u6790\u60c5\u51b5\u3002  \u767e\u6d4e\u795e\u5dde\u514d\u75ab\u80bf\u7624\u5b66\u9996\u5e2d\u533b\u5b66\u5b98\u8d32\u52c7\u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a\u201c\u501f\u52a9\u516c\u53f8\u4e30\u5bcc\u7684\u514d\u75ab\u80bf\u7624\u4ea7\u54c1\u7ebf\uff0c\u6211\u4eec\u6301\u7eed\u53d6\u5f97\u4e86\u5177\u6709\u91cd\u8981\u610f\u4e49\u7684\u7814\u7a76\u8fdb\u5c55\uff0c\u5176\u4e2d\u5305\u62ec\u6b63\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u9886\u57df\u5f00\u5c55\u7684\u4e03\u98793\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u968f\u7740\u5bf9\u836f\u7269\u4e34\u5e8a\u4f5c\u7528\u7406\u89e3\u7684\u4e0d\u65ad\u52a0\u6df1\uff0c\u6211\u4eec\u6b63\u5728\u52a0\u901f\u767e\u6cfd\u5b89®\u5728\u80ba\u764c\u9886\u57df\u7684\u65b0\u578b\u8054\u5408\u7597\u6cd5\u7684\u5f00\u53d1\u8fdb\u7a0b\uff0c\u5305\u62ec\u4e0e\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684\u5728\u7814\u5f3a\u6548\u6297TIGIT\u6297\u4f53ociperlimab\uff0c\u4ee5\u53ca\u4e0e\u5916\u90e8\u5408\u4f5c\u5f00\u53d1\u7684\u5728\u7814\u836f\u7269\uff0c\u5982sitravatinib\u7684\u8054\u5408\u7597\u6cd5\u3002\u6b64\u5916\uff0c\u6211\u4eec\u7684\u79d1\u5b66\u5bb6\u6b63\u5728\u63a2\u7d22\u767e\u6cfd\u5b89®\u5728\u80ba\u764c\u548c\u5176\u4ed6\u5b9e\u4f53\u7624\u9886\u57df\u65b0\u7684\u8054\u5408\u7528\u836f\u6a21\u5f0f\u3002\u540c\u65f6\uff0c\u4f34\u968f\u7740\u4e0e\u8bfa\u534e\u7684\u5408\u4f5c\u63a8\u8fdb\uff0c\u767e\u6cfd\u5b89®\u80fd\u591f\u501f\u52a9\u8bfa\u534e\u5728\u80bf\u7624\u836f\u7269\u7ba1\u7ebf\u4e0a\u7684\u4f18\u52bf\uff0c\u63a2\u7d22\u66f4\u591a\u8054\u5408\u7597\u6cd5\u7684\u53ef\u80fd\u6027\u3002\u6211\u4eec\u671f\u5f85\u901a\u8fc7\u5bf9\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\u60a3\u8005\u5f00\u5c55\u7684\u8054\u5408\u6cbb\u7597\u63a2\u7d22\uff0c\u53d1\u6398\u8fd9\u6b3e\u5dee\u5f02\u5316\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u6cbb\u7597\u6f5c\u529b\uff0c\u60e0\u53ca\u66f4\u591a\u5168\u7403\u60a3\u8005\u3002\u201d \u6b32\u4e86\u89e3\u66f4\u591a\u5173\u4e8e\u767e\u6d4e\u795e\u5dde\u7814\u53d1\u548cESMO\u5e74\u4f1a\u76f8\u5173\u6d3b\u52a8\u7684\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95eehttps:\/\/beigenemedical.eu\/\u3002  \u767e\u6cfd\u5b89®\u5728\u80ba\u764c\u9886\u57df\u5f00\u5c55\u7684\u5e7f\u6cdb\u8054\u5408\u6cbb\u7597\u7814\u7a76\u9879\u76ee \u767e\u6d4e\u795e\u5dde\u6b63\u5728\u52aa\u529b\u63a2\u7d22\u767e\u6cfd\u5b89®\u8054\u5408\u7528\u836f\u7684\u591a\u79cd\u4f5c\u7528\u673a\u5236\uff0c\u5b8c\u5584PD-1\u901a\u8def\u7684\u9776\u5411\u4f5c\u7528\uff0c\u4ee5\u671f\u6539\u5584\u4e34\u5e8a\u6548\u679c\u6216\u514b\u670d\u4e0e\u75be\u75c5\u8fdb\u5c55\u76f8\u5173\u7684\u8010\u836f\u6027\u3002  \u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u6cbb\u7597\u4e2d\uff0c\u8bb8\u591a\u66fe\u63a5\u53d7\u524d\u7ebf\u6297PD-1\u6297\u4f53\u6cbb\u7597\u540e\u5f97\u5230\u7f13\u89e3\u7684\u60a3\u8005\u6700\u7ec8\u56e0\u8010\u836f\u800c\u590d\u53d1\u3002\u901a\u8fc7\u4e0eMirati Therapeutics\u516c\u53f8\u5408\u4f5c\uff0c\u767e\u6d4e\u795e\u5dde\u6b63\u5728\u7814\u7a76\u767e\u6cfd\u5b89®\u4e0esitravatinib\u7684\u8054\u5408\u7597\u6cd5\uff0csitravatinib\u662f\u4e00\u79cd\u6709\u671b\u901a\u8fc7\u9006\u8f6c\u514d\u75ab\u6291\u5236\u80bf\u7624\u5fae\u73af\u5883\uff0c\u4ee5\u514b\u670d\u514d\u75ab\u8010\u53d7\u7684\u5e7f\u8c31\u9009\u62e9\u6027\u7684\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u3002\u767e\u6d4e\u795e\u5dde\u6b63\u5728\u5f00\u5c55\u8be5\u65b0\u578b\u8054\u5408\u6cbb\u7597\u65b9\u6848\u5728NSCLC\u9886\u57df\u76843\u671f\u8bd5\u9a8c\uff0c\u5e76\u5c06\u57282021\u5e74ESMO\u5e74\u4f1a\u4e0a\u5c55\u793a\u5176\u6b63\u5728\u8fdb\u884c\u7684\u5bf9\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\uff08\u5305\u62ec\u521d\u6cbb\u548c\u96be\u6cbb\u6027\u6216\u5bf9\u4e8e\u6297PD-(L)1\u6cbb\u7597\u8010\u836f\u7684\u60a3\u8005\uff09\u76841b\u671f\u8bd5\u9a8c\u7684\u4e34\u5e8a\u7ed3\u679c\u3002 \u767e\u6d4e\u795e\u5dde\u5728\u80ba\u764c\u9886\u57df\u5f00\u5c55\u7684\u53e6\u4e00\u9879\u521b\u65b0\u8054\u5408\u7597\u6cd5\u7814\u7a76\u662f\u767e\u6cfd\u5b89®\u4e0eociperlimab\u7684\u7ec4\u5408\u3002Ociperlimab\u662f\u4e00\u6b3e\u5f3a\u6548\u3001\u5177\u6709\u5b8c\u6574Fc\u6bb5\u529f\u80fd\u7684\u5728\u7814\u6297TIGIT\u6297\u4f53\uff0c\u76ee\u524d\u8be5\u8054\u5408\u7597\u6cd5\u6b63\u5904\u4e8e3\u671f\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u3002TIGIT\u662f\u4e00\u79cd\u5171\u6291\u5236\u6027\u514d\u75ab\u68c0\u67e5\u70b9\u53d7\u4f53\uff0c\u8868\u8fbe\u4e8e\u591a\u79cd\u514d\u75ab\u7ec6\u80de\u3002\u6700\u8fd1\u53d1\u73b0\uff0cTIGIT\u53ef\u4f5c\u4e3a\u65b0\u7684\u6cbb\u7597\u9776\u70b9\uff0c\u4e0ePD-1\u8054\u5408\u6709\u53ef\u80fd\u8fdb\u4e00\u6b65\u6291\u5236\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u3002\u767e\u6cfd\u5b89®\u5728\u80ba\u764c\u9886\u57df\u7684\u5e7f\u6cdb\u8054\u5408\u7597\u6cd5\u8fd8\u5305\u62ec\u4e0ePI3K\u03b4\u6291\u5236\u5242BGB-10188\u3001\u6297TIM-3\u6297\u4f53BGB-A425\u548c\u5316\u7597\u7684\u8054\u5408\u3002 \u4ee5\u5353\u8d8a\u79d1\u7814\u5b9e\u529b\u548c\u4e34\u5e8a\u6d1e\u5bdf\u4e3a\u9a71\u52a8\uff0c\u6301\u7eed\u62d3\u5c55NSCLC\u9886\u57df\u7684\u5f00\u53d1 \u8fd1\u5e74\u6765\uff0c\u5168\u7403\u5728NSCLC\u9886\u57df\u7684\u6cbb\u7597\u624b\u6bb5\u867d\u53d6\u5f97\u4e86\u4e00\u5b9a\u8fdb\u5c55\uff0c\u4f46\u4f5c\u4e3a\u4e00\u9879\u9ad8\u53d1\u7684\u764c\u75c7\u7c7b\u578b\uff0c\u5728\u4e34\u5e8a\u6cbb\u7597\u4e0a\u4ecd\u5b58\u5728\u5927\u91cf\u5c1a\u672a\u88ab\u6ee1\u8db3\u7684\u6cbb\u7597\u9700\u6c42\u3002\u767e\u6d4e\u795e\u5dde\u76ee\u524d\u6b63\u5728\u4e00\u9879\u7efc\u5408\u6027NSCLC\u9879\u76ee\u4e2d\u8bc4\u4f30\u767e\u6cfd\u5b89®\u7684\u8868\u73b0\uff0c\u8be5\u9879\u76ee\u5305\u62ec10\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6db5\u76d6\u4e86\u4ece\u65e9\u671f\u5230\u540e\u7ebf\u7684\u60a3\u8005\u3002  \u4e3a\u4e86\u6df1\u5165\u63a2\u7d22\u4e0d\u540c\u60a3\u8005\u7279\u5f81\u5bf9\u6cbb\u7597\u7ed3\u679c\u7684\u5f71\u54cd\uff0c\u767e\u6d4e\u795e\u5dde\u7684\u514d\u75ab\u80bf\u7624\u5b66\u56e2\u961f\u4ece\u5730\u57df\u3001\u75be\u75c5\u5206\u671f\u3001\u5438\u70df\u72b6\u51b5\uff0c\u4ee5\u53ca\u751f\u7269\u6807\u5fd7\u7269\u7684\u4f7f\u7528\u7b49\u65b9\u9762\u5206\u6790\u4e86NSCLC\u8bd5\u9a8c\u7684\u4e34\u5e8a\u7ed3\u679c\u3002  \u767e\u6d4e\u795e\u5dde\u6700\u8fd1\u57282021\u5e74\u4e16\u754c\u80ba\u764c\u5927\u4f1a\uff08WCLC\uff09\u4e0a\u5c55\u793a\u4e86RATIONALE 307\u8bd5\u9a8c\u4e9a\u7ec4\u5206\u6790\u7684\u7ed3\u679c\u3002\u8be5\u4e9a\u7ec4\u5206\u6790\u8868\u660e\u4e0d\u8bbaPD-L1\u8868\u8fbe\u3001\u8840\u6db2\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff08TMB\uff09\u3001\u7ec4\u7ec7TMB\u548c\u75be\u75c5\u5206\u671f\uff08IIIB\u6216IV\u671f\uff09\u5982\u4f55\uff0c\u767e\u6cfd\u5b89®\u8054\u5408\u5316\u7597\u5728\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u521d\u6cbb\u60a3\u8005\u4e2d\u5c55\u793a\u4e86\u4e00\u81f4\u7684\u751f\u5b58\u83b7\u76ca\u3002  \u57282021\u5e74ESMO\u5e74\u4f1a\u4e0a\uff0c\u767e\u6d4e\u795e\u5dde\u8fd8\u5c06\u62a5\u544aRATIONALE 304\u548cRATIONALE 307\u4e24\u9879\u4e00\u7ebfNSCLC\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5438\u70df\u8005\u4e0e\u4e0d\u5438\u70df\u60a3\u8005\u7684\u989d\u5916\u5206\u6790\u7ed3\u679c\u3002 \u6b64\u5916\uff0c\u767e\u6d4e\u795e\u5dde\u6b63\u5728\u63a2\u7d22\u767e\u6cfd\u5b89®\u4f5c\u4e3a\u65e9\u671f\u6cbb\u7597\u9009\u62e9\u7684\u6f5c\u529b\uff0c\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u5168\u74033\u671f\u8bd5\u9a8cRATIONALE 315\u4ee5\u63a2\u7d22\u767e\u6cfd\u5b89®\u5728\u65b0\u8f85\u52a9\u6216\u8f85\u52a9\u6cbb\u7597\u9886\u57df\u7684\u5e94\u7528\u3002 \u767e\u6d4e\u795e\u5dde\u57282021\u5e74ESMO\u5e74\u4f1a\u4e0a\u5c55\u793a\u7684\u7535\u5b50\u6d77\u62a5 \u6458\u8981\u7f16\u53f7 \u6807\u9898 \u4e3b\u8981\u4f5c\u8005 3649 Sitravatinib\u8054\u5408\u66ff\u96f7\u5229\u73e0\u5355\u6297\u7528\u4e8e\u6cbb\u7597\u5bf9\u4e8e\u6297PD-(L)1\u96be\u6cbb\/\u8010\u836f\u7684\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005 \u9ad8\u535a\uff0c\u533b\u5b66\u535a\u58eb\uff0c\u535a\u58eb Blacktown\u764c\u75c7\u548c\u8840\u6db2\u5b66\u4e2d\u5fc3\uff08\u6fb3\u5927\u5229\u4e9a\uff09 3457 Sitravatinib\u8054\u5408\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6cbb\u7597\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005 \u5468\u6e05\uff0c\u533b\u5b66\u535a\u58eb\uff0c\u535a\u58eb \u5e7f\u4e1c\u7701\u4eba\u6c11\u533b\u9662\uff08\u4e2d\u56fd\uff09 2562 \u66ff\u96f7\u5229\u73e0\u5355\u6297\u5355\u836f\u6cbb\u7597\u540e\u5bf9\u7ecf\u6cbb\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c\u60a3\u8005\u5065\u5eb7\u76f8\u5173\u751f\u6d3b\u8d28\u91cf\u7684\u5f71\u54cd \u4efb\u6b63\u521a\uff0c\u533b\u5b66\u535a\u58eb\uff0c\u535a\u58eb \u590d\u65e6\u5927\u5b66\u9644\u5c5e\u4e2d\u5c71\u533b\u9662\uff08\u4e2d\u56fd\uff09 3786 RATIONALE 304\uff1a\u66ff\u96f7\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u5bf9\u6bd4\u5355\u72ec\u5316\u7597\u4f5c\u4e3a\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u5438\u70df\u8005\u4e0e\u4e0d\u5438\u70df\u8005\u7684\u4e00\u7ebf\u6cbb\u7597 \u9646\u821c\uff0c\u533b\u5b66\u535a\u58eb 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