{"id":43603,"date":"2021-09-09T07:17:00","date_gmt":"2021-09-09T00:17:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021090907170043603"},"modified":"2021-09-09T21:37:05","modified_gmt":"2021-09-09T13:37:05","slug":"%e3%80%90wclc-2021%e3%80%91%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%afapg-1252%e8%8e%b72021%e4%b8%96%e7%95%8c%e8%82%ba%e7%99%8c%e5%a4%a7%e4%bc%9a%e5%8f%a3%e5%a4%b4%e6%8a%a5%e5%91%8a%ef%bc%8c%e6%8f%ad","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021090907170043603","title":{"rendered":"\u3010WCLC 2021\u3011\u4e9a\u76db\u533b\u836fAPG-1252\u83b72021\u4e16\u754c\u80ba\u764c\u5927\u4f1a\u53e3\u5934\u62a5\u544a\uff0c\u63ed\u793a\u8054\u5408\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597\u8010\u836f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u6f5c\u529b"},"content":{"rendered":"<table border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/logo_Logo-27.jpg\" border=\"0\" alt=\"\" title=\"logo\" hspace=\"0\" vspace=\"0\" width=\"118\" \/><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><p>\u4e2d\u56fd\u82cf\u5dde\u548c\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e022021\u5e749\u67089\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u81f4\u529b\u4e8e\u5728\u80bf\u7624\u3001\u4e59\u809d\u53ca\u4e0e\u8870\u8001\u76f8\u5173\u75be\u75c5\u7b49\u6cbb\u7597\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\u2014\u2014\u4e9a\u76db\u533b\u836f\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u57282021\u5e74\u4e16\u754c\u80ba\u764c\u5927\u4f1a\uff08WCLC\uff09\u4e0a\uff0c\u5df2\u4ee5\u5c0f\u578b\u53e3\u5934\u62a5\u544a\u5f62\u5f0f\uff08Mini Oral Session\uff09\u516c\u5e03\u4e86\u539f\u521b\u53cc\u9776\u70b9Bcl-2\/Bcl-xL\u6291\u5236\u5242pelcitoclax\uff08APG-1252\uff09\u8054\u5408\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597&nbsp;EGFR TKI\u8010\u836f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684Ib\u671f\u4e34\u5e8a\u7814\u7a76\u6210\u679c\u3002\u8be5\u9879\u4e34\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u5c71\u5927\u5b66\u80bf\u7624\u9632\u6cbb\u4e2d\u5fc3\u5f20\u529b\u6559\u6388\u4e3a\u62a5\u544a\u4eba\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder1\">\n<\/p><\/div>\n<p>WCLC\u662f\u7531\u56fd\u9645\u80ba\u764c\u7814\u7a76\u534f\u4f1a(IASLC)\u7ec4\u7ec7\u7684\u4e16\u754c\u4e0a\u6700\u5927\u7684\u81f4\u529b\u4e8e\u80ba\u764c\u548c\u5176\u4ed6\u80f8\u90e8\u6076\u6027\u80bf\u7624\u7684\u591a\u5b66\u79d1\u80bf\u7624\u5b66\u4f1a\u8bae\uff0c\u805a\u7126\u8be5\u9886\u57df\u6700\u524d\u6cbf\u7684\u79d1\u7814\u4e0e\u4e34\u5e8a\u8fdb\u5c55\u3002\u4e9a\u76db\u533b\u836f\u5728\u672c\u6b21\u5927\u4f1a\u4e0a\u516c\u5e03\u7684\u662f\u4e00\u9879APG-1252\u8054\u5408\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597\u665a\u671fEGFR\u7a81\u53d8\u9633\u6027NSCLC\u60a3\u8005\u7684\u5355\u81c2\u3001\u591a\u4e2d\u5fc3\u3001Ib\u671f\u7684\u5242\u91cf\u63a2\u7d22\u548c\u5242\u91cf\u6269\u5c55\u4e34\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30APG-1252\u8054\u5408\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597\u7684\u836f\u4ee3\u52a8\u529b\u5b66\uff08PK\uff09\u3001\u5b89\u5168\u6027\u548c\u521d\u6b65\u7597\u6548\u3002<\/p>\n<p>APG-1252\u4e3a\u4e9a\u76db\u533b\u836f\u81ea\u4e3b\u7814\u53d1\u7684\u65b0\u578bBcl-2\/Bcl-xL\u53cc\u9776\u70b9\u6291\u5236\u5242\uff0c\u53ef\u901a\u8fc7\u9009\u62e9\u6027\u6291\u5236Bcl-2\u53caBcl-xL\u86cb\u767d\u4fee\u590d\u7ec6\u80de\u51cb\u4ea1\u3002\u5728\u6cbb\u7597EGFR\u7a81\u53d8\u578bNSCLC\u7684\u4e34\u5e8a\u524d\u52a8\u7269\u5b9e\u9a8c\u4e2d\uff0cAPG-1252\u8054\u5408\u5965\u5e0c\u66ff\u5c3c\u5bf9\u4e8e\u5965\u5e0c\u66ff\u5c3c\u654f\u611f\u6216\u8010\u836f\u6a21\u578b\u5747\u663e\u793a\u51fa\u534f\u540c\u4f5c\u7528\u3002\u56e0\u6b64\uff0cAPG-1252\u6709\u53ef\u80fd\u4e3a\u8fd9\u90e8\u5206\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002<\/p>\n<p>APG-1252\u5728\u672c\u6b21WCLC\u4e0a\u7684\u5c0f\u578b\u53e3\u5934\u62a5\u544a\u5173\u952e\u4fe1\u606f\u5982\u4e0b\uff1a<\/p>\n<p><b>Phase <span class=\"xn-money\">1b<\/span> Study of Pelcitoclax (APG-1252) in Combination With Osimertinib in Patients With EGFR TKI-Resistant NSCLC<\/b><\/p>\n<p><b>Pelcitoclax<\/b><b>\uff08<\/b><b>APG-1252<\/b><b>\uff09\u8054\u5408\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597<\/b><b>&nbsp;EGFR TKI<\/b><b>\u8010\u836f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08<\/b><b>NSCLC<\/b><b>\uff09\u60a3\u8005\u7684<\/b><b>Ib<\/b><b>\u671f\u7814\u7a76<\/b><\/p>\n<p>\u7f16\u53f7\uff1aMA02.06<\/p>\n<p>\u4e13\u573a\uff1a\u65b0\u578b\u836f\u7269\u53ca\u9776\u5411\u7597\u6cd5\/Novel Therapeutics and Targeted Therapies<\/p>\n<p>\u65f6\u95f4\uff1a9\u67088\u65e510\uff1a05-10\uff1a10\uff08\u5c71\u5730\u65f6\u95f4\uff09\/9\u67089\u65e500:05 \u2013 00:10\uff08\u4e2d\u56fd\u65f6\u95f4\uff09<\/p>\n<ul type=\"disc\">\n<li>\u8fd9\u662f\u4e00\u9879APG-1252\u8054\u5408\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597\u665a\u671fEGFR\u7a81\u53d8\u9633\u6027NSCLC\u60a3\u8005\u7684\u5355\u81c2\u3001\u591a\u4e2d\u5fc3\u3001Ib\u671f\u7814\u7a76\uff0c\u5305\u62ec\u5242\u91cf\u63a2\u7d22\u548c\u5242\u91cf\u6269\u5c55\u4e24\u90e8\u5206\u3002APG-1252 160mg\u6216240mg \uff0c\u6bcf\u5468\u9759\u8109\u6ce8\u5c04\u4e00\u6b21\uff1b\u5965\u5e0c\u66ff\u5c3c80mg\uff0c\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\u3002\u5242\u91cf\u63a2\u7d22\u9636\u6bb5\u4e3b\u8981\u8bc4\u4f30\u8054\u5408\u6cbb\u7597\u5728EGFR TKI\u6cbb\u7597\u8fdb\u5c55\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u4e0e\u8010\u53d7\u6027\uff0c\u786e\u5b9aAPG-1252\u7684MTD\u548c\/\u6216RP2D\u3002\u5242\u91cf\u6269\u5c55\u9636\u6bb5\u5305\u62ec2\u4e2a\u961f\u5217\uff1a\u961f\u5217\u4e00\uff0c\u8bc4\u4f30\u8054\u5408\u6cbb\u7597\u5728\u4e09\u4ee3EGFR TKI\u8010\u836f\u60a3\u8005\u4e2d\u7684\u7597\u6548\uff1b\u961f\u5217\u4e8c\uff0c\u8bc4\u4f30\u8054\u5408\u6cbb\u7597\u5728\u672a\u7ecf\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597\u60a3\u8005\u4e2d\u7684\u7597\u6548\u3002\u4e24\u4e2a\u961f\u5217\u5c06\u5404\u5165\u7ec420\u4f8b\u53d7\u8bd5\u8005\u3002\n<\/li>\n<li>\u622a\u81f32021\u5e746\u670824\u65e5\uff0c56\u4f8b\u60a3\u8005\u88ab\u7eb3\u5165\u7814\u7a76\u3002\u5176\u4e2d\u5242\u91cf\u63a2\u7d22\u548c\u5242\u91cf\u6269\u5c55\u961f\u5217\u4e00\u517133\u4f8b\uff0c\u4ed6\u4eec\u65e2\u5f80\u4e2d\u4f4d\u6cbb\u7597\u7ebf\u6570\uff08\u8303\u56f4\uff09\u4e3a4\uff081-10\uff09\uff0c87.9%\u63a5\u53d7\u8fc7\u5316\u7597\uff0c75.8%\u63a5\u53d7\u8fc7\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597\uff0c63.6%\u5165\u7ec4\u65f6\u6709\u8111\u8f6c\u79fb\u3002\u961f\u5217\u4e8c\u517123\u4f8b\uff0c\u4ed6\u4eec\u65e2\u5f80\u4e2d\u4f4d\u6cbb\u7597\u7ebf\u6570\uff08\u8303\u56f4\uff09\u4e3a0\uff080-2\uff09, 8.7%\u63a5\u53d7\u8fc7\u5316\u7597\uff0c17.4%\u63a5\u53d7\u8fc7\u4e00\u4ee3TKI\u6cbb\u7597\uff0c30.4%\u5165\u7ec4\u65f6\u6709\u8111\u8f6c\u79fb\u3002\n<\/li>\n<li>\u5242\u91cf\u63a2\u7d22\u9636\u6bb5\uff0c\u53ef\u8bc4\u4f30\u768411\u4f8b\u60a3\u8005\u4e2d\u89c2\u5bdf\u52301\u4f8bPR\uff1b\u5242\u91cf\u6269\u5c55\u961f\u5217\u4e00\uff0c\u53ef\u8bc4\u4f30\u768420\u4f8b\u60a3\u8005\u4e2d\u89c2\u5bdf\u52303\u4f8bPR\uff082\u4f8b\u4e3a\u5965\u5e0c\u66ff\u5c3c\u8010\u836f\uff09\u300113\u4f8bSD\uff0cORR\u4e3a15%\u3001DCR\u4e3a80%\u3002\u5242\u91cf\u6269\u5c55\u961f\u5217\u4e8c\uff0c\u5728\u53ef\u8bc4\u4f30\u768422\u4f8b\u60a3\u8005\u4e2d\uff0c\u5176\u4e2d\u5305\u62ec3\u4f8bEGFR\u57fa\u56e020\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u60a3\u8005\uff0c\u89c2\u5bdf\u523013\u4f8bPR\u30018\u4f8bSD\uff0cORR\u4e3a59.1%\u3001DCR\u4e3a95.5%\u3002\n<\/li>\n<li>\u5242\u91cf\u63a2\u7d22\u9636\u6bb5\uff0c\u5728APG-1252 240mg\u53d1\u751f1\u4f8b4\u7ea7\u8840\u5c0f\u677f\u51cf\u5c11\u7684DLT\u3002\u800c\u5728160mg\u6ca1\u6709\u53d1\u751f3\u7ea7\u53ca\u4ee5\u4e0a\u7684\u8840\u5c0f\u677f\u51cf\u5c11\uff0cALT\u548cAST\u5347\u9ad8\u7684\u6bd4\u4f8b\u4e5f\u8fdc\u8fdc\u4f4e\u4e8e240mg\u3002\u56e0\u6b64RP2D\u786e\u5b9a\u4e3aAPG-1252 160mg\u8054\u5408\u5965\u5e0c\u66ff\u5c3c80mg\u3002\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u4e3b\u8981\u662f\u77ed\u6682\u6027\u8840\u5c0f\u677f\u51cf\u5c11\u3001AST\u5347\u9ad8\u3001ALT\u5347\u9ad8\u3001\u6dc0\u7c89\u9176\u5347\u9ad8\u3001\u8840\u808c\u9150\u5347\u9ad8\u3001\u767d\u7ec6\u80de\u51cf\u5c11\u3001\u8d2b\u8840\u4ee5\u53ca\u76ae\u75b9\u3002\n<\/li>\n<li><b>\u7ed3\u8bba\uff1a<\/b>APG-1252\u8054\u5408\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\u3002\u5728\u90e8\u5206\u5965\u5e0c\u66ff\u5c3c\u8010\u836f\u7684\u60a3\u8005\u4e2d\u521d\u6b65\u89c2\u5bdf\u5230\u534f\u540c\u6297\u80bf\u7624\u6548\u5e94\u3002\u5728\u5965\u5e0c\u66ff\u5c3c\u521d\u6cbb\u60a3\u8005\u4e2d\u521d\u6b65\u89c2\u5bdf\u5230APG-1252\u4e0e\u90a3\u7ef4\u514b\u62c9\uff08navitoclax\uff09\u6709\u76f8\u4f3c\u7684\u534f\u540c\u5965\u5e0c\u66ff\u5c3c\u7684\u4f5c\u7528\u3002<\/li>\n<\/ul>\n<p>\u201c\u867d\u7136\u5965\u5e0c\u66ff\u5c3c\u5df2\u6210\u4e3aEGFR\u7a81\u53d8NSCLC\u60a3\u8005\u7684\u4e00\u7ebf\u9996\u9009\u6cbb\u7597\u836f\u7269\uff0c\u4f46\u662f\u5bf9\u4e8e\u5176\u8010\u836f\u7684\u60a3\u8005\uff0c\u76ee\u524d\u8fd8\u6ca1\u6709\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6848\u3002\u6b64\u6b21\u516c\u5e03\u7684APG-1252\u8054\u5408\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597\u7684\u7814\u7a76\u6570\u636e\u663e\u793a\uff0c\u5728\u90e8\u5206\u5965\u5e0c\u66ff\u5c3c\u8010\u836f\u7684\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u534f\u540c\u6297\u80bf\u7624\u6548\u5e94\uff0c\u6709\u671b\u4e3a\u89e3\u51b3\u8be5\u8010\u836f\u95ee\u9898\u63d0\u4f9b\u4e86\u65b0\u7684\u6cbb\u7597\u53ef\u80fd\u3002\u201d\u8be5\u9879\u4e34\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u4e2d\u5c71\u5927\u5b66\u80bf\u7624\u9632\u6cbb\u4e2d\u5fc3\u5f20\u529b\u6559\u6388\u8868\u793a\uff0c\u201c\u6211\u4eec\u540e\u7eed\u4f1a\u5f00\u5c55\u66f4\u591a\u76f8\u5173\u7684\u751f\u7269\u6807\u5fd7\u7269\u5206\u6790\uff0c\u4ee5\u5bfb\u6c42\u5bcc\u96c6\u6709\u6548\u4eba\u7fa4\u7684\u53ef\u80fd\u6027\u3002\u201d<\/p>\n<p>\u4e9a\u76db\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u201c\u9488\u5bf9NSCLC\u7684\u6cbb\u7597\u76ee\u524d\u4ecd\u7136\u5b58\u5728\u5de8\u5927\u7684\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\uff0c\u7279\u522b\u662fEGFR TKI\u8010\u836f\u60a3\u8005\u76ee\u524d\u4ecd\u7f3a\u4e4f\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u672c\u6b21WCLC\u4e0a\u516c\u5e03\u7684\u6570\u636e\u5c55\u793a\u4e86APG-1252\u5728\u8054\u5408\u6cbb\u7597EGFR TKI\u8010\u836f\u65b9\u9762\u7684\u8f83\u5927\u6f5c\u529b\uff0c\u4e3a\u8be5\u836f\u7269\u8fdb\u4e00\u6b65\u4e34\u5e8a\u63a2\u7d22\u63d0\u4f9b\u66f4\u591a\u79d1\u5b66\u4f9d\u636e\u3002\u6211\u4eec\u5c06\u52a0\u5feb\u63a8\u8fdb\u4e34\u5e8a\u5f00\u53d1\uff0c\u671f\u5f85\u65e9\u65e5\u4e3a\u60a3\u8005\u63d0\u4f9b\u65b0\u578b\u7684\u6cbb\u7597\u9009\u62e9\u3002\u201d<\/p>\n<p>\u76f8\u5173\u94fe\u63a5 :<\/p>\n<blockquote class=\"wp-embedded-content\" data-secret=\"81pq3aLL3u\"><p><a href=\"https:\/\/www.ascentagepharma.com\/\">A Leader in the Discovery and Development of Small Molecules that Disrupt Protein-Protein Interactions<\/a><\/p><\/blockquote>\n<p><iframe class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; clip: rect(1px, 1px, 1px, 1px);\" title=\"&#8220;A Leader in the Discovery and Development of Small Molecules that Disrupt Protein-Protein Interactions&#8221; &#8212; Ascentage Pharma\" src=\"https:\/\/www.ascentagepharma.com\/embed\/#?secret=81pq3aLL3u\" data-secret=\"81pq3aLL3u\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e2d\u56fd\u82cf\u5dde\u548c\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e022021\u5e749\u67089\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u81f4\u529b\u4e8e\u5728\u80bf\u7624\u3001\u4e59\u809d\u53ca\u4e0e\u8870\u8001\u76f8\u5173\u75be\u75c5\u7b49\u6cbb\u7597\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\u2014\u2014\u4e9a\u76db\u533b\u836f\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u57282021\u5e74\u4e16\u754c\u80ba\u764c\u5927\u4f1a\uff08WCLC\uff09\u4e0a\uff0c\u5df2\u4ee5\u5c0f\u578b\u53e3\u5934\u62a5\u544a\u5f62\u5f0f\uff08Mini Oral Session\uff09\u516c\u5e03\u4e86\u539f\u521b\u53cc\u9776\u70b9Bcl-2\/Bcl-xL\u6291\u5236\u5242pelcitoclax\uff08APG-1252\uff09\u8054\u5408\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597&nbsp;EGFR TKI\u8010\u836f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684Ib\u671f\u4e34\u5e8a\u7814\u7a76\u6210\u679c\u3002\u8be5\u9879\u4e34\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u5c71\u5927\u5b66\u80bf\u7624\u9632\u6cbb\u4e2d\u5fc3\u5f20\u529b\u6559\u6388\u4e3a\u62a5\u544a\u4eba\u3002 WCLC\u662f\u7531\u56fd\u9645\u80ba\u764c\u7814\u7a76\u534f\u4f1a(IASLC)\u7ec4\u7ec7\u7684\u4e16\u754c\u4e0a\u6700\u5927\u7684\u81f4\u529b\u4e8e\u80ba\u764c\u548c\u5176\u4ed6\u80f8\u90e8\u6076\u6027\u80bf\u7624\u7684\u591a\u5b66\u79d1\u80bf\u7624\u5b66\u4f1a\u8bae\uff0c\u805a\u7126\u8be5\u9886\u57df\u6700\u524d\u6cbf\u7684\u79d1\u7814\u4e0e\u4e34\u5e8a\u8fdb\u5c55\u3002\u4e9a\u76db\u533b\u836f\u5728\u672c\u6b21\u5927\u4f1a\u4e0a\u516c\u5e03\u7684\u662f\u4e00\u9879APG-1252\u8054\u5408\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597\u665a\u671fEGFR\u7a81\u53d8\u9633\u6027NSCLC\u60a3\u8005\u7684\u5355\u81c2\u3001\u591a\u4e2d\u5fc3\u3001Ib\u671f\u7684\u5242\u91cf\u63a2\u7d22\u548c\u5242\u91cf\u6269\u5c55\u4e34\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30APG-1252\u8054\u5408\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597\u7684\u836f\u4ee3\u52a8\u529b\u5b66\uff08PK\uff09\u3001\u5b89\u5168\u6027\u548c\u521d\u6b65\u7597\u6548\u3002 APG-1252\u4e3a\u4e9a\u76db\u533b\u836f\u81ea\u4e3b\u7814\u53d1\u7684\u65b0\u578bBcl-2\/Bcl-xL\u53cc\u9776\u70b9\u6291\u5236\u5242\uff0c\u53ef\u901a\u8fc7\u9009\u62e9\u6027\u6291\u5236Bcl-2\u53caBcl-xL\u86cb\u767d\u4fee\u590d\u7ec6\u80de\u51cb\u4ea1\u3002\u5728\u6cbb\u7597EGFR\u7a81\u53d8\u578bNSCLC\u7684\u4e34\u5e8a\u524d\u52a8\u7269\u5b9e\u9a8c\u4e2d\uff0cAPG-1252\u8054\u5408\u5965\u5e0c\u66ff\u5c3c\u5bf9\u4e8e\u5965\u5e0c\u66ff\u5c3c\u654f\u611f\u6216\u8010\u836f\u6a21\u578b\u5747\u663e\u793a\u51fa\u534f\u540c\u4f5c\u7528\u3002\u56e0\u6b64\uff0cAPG-1252\u6709\u53ef\u80fd\u4e3a\u8fd9\u90e8\u5206\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002 APG-1252\u5728\u672c\u6b21WCLC\u4e0a\u7684\u5c0f\u578b\u53e3\u5934\u62a5\u544a\u5173\u952e\u4fe1\u606f\u5982\u4e0b\uff1a Phase 1b Study of Pelcitoclax (APG-1252) in Combination With Osimertinib in Patients With EGFR TKI-Resistant NSCLC Pelcitoclax\uff08APG-1252\uff09\u8054\u5408\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597&nbsp;EGFR TKI\u8010\u836f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684Ib\u671f\u7814\u7a76 \u7f16\u53f7\uff1aMA02.06 \u4e13\u573a\uff1a\u65b0\u578b\u836f\u7269\u53ca\u9776\u5411\u7597\u6cd5\/Novel Therapeutics and Targeted Therapies \u65f6\u95f4\uff1a9\u67088\u65e510\uff1a05-10\uff1a10\uff08\u5c71\u5730\u65f6\u95f4\uff09\/9\u67089\u65e500:05 \u2013 00:10\uff08\u4e2d\u56fd\u65f6\u95f4\uff09 \u8fd9\u662f\u4e00\u9879APG-1252\u8054\u5408\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597\u665a\u671fEGFR\u7a81\u53d8\u9633\u6027NSCLC\u60a3\u8005\u7684\u5355\u81c2\u3001\u591a\u4e2d\u5fc3\u3001Ib\u671f\u7814\u7a76\uff0c\u5305\u62ec\u5242\u91cf\u63a2\u7d22\u548c\u5242\u91cf\u6269\u5c55\u4e24\u90e8\u5206\u3002APG-1252 160mg\u6216240mg \uff0c\u6bcf\u5468\u9759\u8109\u6ce8\u5c04\u4e00\u6b21\uff1b\u5965\u5e0c\u66ff\u5c3c80mg\uff0c\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\u3002\u5242\u91cf\u63a2\u7d22\u9636\u6bb5\u4e3b\u8981\u8bc4\u4f30\u8054\u5408\u6cbb\u7597\u5728EGFR TKI\u6cbb\u7597\u8fdb\u5c55\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u4e0e\u8010\u53d7\u6027\uff0c\u786e\u5b9aAPG-1252\u7684MTD\u548c\/\u6216RP2D\u3002\u5242\u91cf\u6269\u5c55\u9636\u6bb5\u5305\u62ec2\u4e2a\u961f\u5217\uff1a\u961f\u5217\u4e00\uff0c\u8bc4\u4f30\u8054\u5408\u6cbb\u7597\u5728\u4e09\u4ee3EGFR TKI\u8010\u836f\u60a3\u8005\u4e2d\u7684\u7597\u6548\uff1b\u961f\u5217\u4e8c\uff0c\u8bc4\u4f30\u8054\u5408\u6cbb\u7597\u5728\u672a\u7ecf\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597\u60a3\u8005\u4e2d\u7684\u7597\u6548\u3002\u4e24\u4e2a\u961f\u5217\u5c06\u5404\u5165\u7ec420\u4f8b\u53d7\u8bd5\u8005\u3002 \u622a\u81f32021\u5e746\u670824\u65e5\uff0c56\u4f8b\u60a3\u8005\u88ab\u7eb3\u5165\u7814\u7a76\u3002\u5176\u4e2d\u5242\u91cf\u63a2\u7d22\u548c\u5242\u91cf\u6269\u5c55\u961f\u5217\u4e00\u517133\u4f8b\uff0c\u4ed6\u4eec\u65e2\u5f80\u4e2d\u4f4d\u6cbb\u7597\u7ebf\u6570\uff08\u8303\u56f4\uff09\u4e3a4\uff081-10\uff09\uff0c87.9%\u63a5\u53d7\u8fc7\u5316\u7597\uff0c75.8%\u63a5\u53d7\u8fc7\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597\uff0c63.6%\u5165\u7ec4\u65f6\u6709\u8111\u8f6c\u79fb\u3002\u961f\u5217\u4e8c\u517123\u4f8b\uff0c\u4ed6\u4eec\u65e2\u5f80\u4e2d\u4f4d\u6cbb\u7597\u7ebf\u6570\uff08\u8303\u56f4\uff09\u4e3a0\uff080-2\uff09, 8.7%\u63a5\u53d7\u8fc7\u5316\u7597\uff0c17.4%\u63a5\u53d7\u8fc7\u4e00\u4ee3TKI\u6cbb\u7597\uff0c30.4%\u5165\u7ec4\u65f6\u6709\u8111\u8f6c\u79fb\u3002 \u5242\u91cf\u63a2\u7d22\u9636\u6bb5\uff0c\u53ef\u8bc4\u4f30\u768411\u4f8b\u60a3\u8005\u4e2d\u89c2\u5bdf\u52301\u4f8bPR\uff1b\u5242\u91cf\u6269\u5c55\u961f\u5217\u4e00\uff0c\u53ef\u8bc4\u4f30\u768420\u4f8b\u60a3\u8005\u4e2d\u89c2\u5bdf\u52303\u4f8bPR\uff082\u4f8b\u4e3a\u5965\u5e0c\u66ff\u5c3c\u8010\u836f\uff09\u300113\u4f8bSD\uff0cORR\u4e3a15%\u3001DCR\u4e3a80%\u3002\u5242\u91cf\u6269\u5c55\u961f\u5217\u4e8c\uff0c\u5728\u53ef\u8bc4\u4f30\u768422\u4f8b\u60a3\u8005\u4e2d\uff0c\u5176\u4e2d\u5305\u62ec3\u4f8bEGFR\u57fa\u56e020\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u60a3\u8005\uff0c\u89c2\u5bdf\u523013\u4f8bPR\u30018\u4f8bSD\uff0cORR\u4e3a59.1%\u3001DCR\u4e3a95.5%\u3002 \u5242\u91cf\u63a2\u7d22\u9636\u6bb5\uff0c\u5728APG-1252 240mg\u53d1\u751f1\u4f8b4\u7ea7\u8840\u5c0f\u677f\u51cf\u5c11\u7684DLT\u3002\u800c\u5728160mg\u6ca1\u6709\u53d1\u751f3\u7ea7\u53ca\u4ee5\u4e0a\u7684\u8840\u5c0f\u677f\u51cf\u5c11\uff0cALT\u548cAST\u5347\u9ad8\u7684\u6bd4\u4f8b\u4e5f\u8fdc\u8fdc\u4f4e\u4e8e240mg\u3002\u56e0\u6b64RP2D\u786e\u5b9a\u4e3aAPG-1252 160mg\u8054\u5408\u5965\u5e0c\u66ff\u5c3c80mg\u3002\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u4e3b\u8981\u662f\u77ed\u6682\u6027\u8840\u5c0f\u677f\u51cf\u5c11\u3001AST\u5347\u9ad8\u3001ALT\u5347\u9ad8\u3001\u6dc0\u7c89\u9176\u5347\u9ad8\u3001\u8840\u808c\u9150\u5347\u9ad8\u3001\u767d\u7ec6\u80de\u51cf\u5c11\u3001\u8d2b\u8840\u4ee5\u53ca\u76ae\u75b9\u3002 \u7ed3\u8bba\uff1aAPG-1252\u8054\u5408\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\u3002\u5728\u90e8\u5206\u5965\u5e0c\u66ff\u5c3c\u8010\u836f\u7684\u60a3\u8005\u4e2d\u521d\u6b65\u89c2\u5bdf\u5230\u534f\u540c\u6297\u80bf\u7624\u6548\u5e94\u3002\u5728\u5965\u5e0c\u66ff\u5c3c\u521d\u6cbb\u60a3\u8005\u4e2d\u521d\u6b65\u89c2\u5bdf\u5230APG-1252\u4e0e\u90a3\u7ef4\u514b\u62c9\uff08navitoclax\uff09\u6709\u76f8\u4f3c\u7684\u534f\u540c\u5965\u5e0c\u66ff\u5c3c\u7684\u4f5c\u7528\u3002 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\u4e9a\u76db\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u201c\u9488\u5bf9NSCLC\u7684\u6cbb\u7597\u76ee\u524d\u4ecd\u7136\u5b58\u5728\u5de8\u5927\u7684\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\uff0c\u7279\u522b\u662fEGFR TKI\u8010\u836f\u60a3\u8005\u76ee\u524d\u4ecd\u7f3a\u4e4f\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u672c\u6b21WCLC\u4e0a\u516c\u5e03\u7684\u6570\u636e\u5c55\u793a\u4e86APG-1252\u5728\u8054\u5408\u6cbb\u7597EGFR TKI\u8010\u836f\u65b9\u9762\u7684\u8f83\u5927\u6f5c\u529b\uff0c\u4e3a\u8be5\u836f\u7269\u8fdb\u4e00\u6b65\u4e34\u5e8a\u63a2\u7d22\u63d0\u4f9b\u66f4\u591a\u79d1\u5b66\u4f9d\u636e\u3002\u6211\u4eec\u5c06\u52a0\u5feb\u63a8\u8fdb\u4e34\u5e8a\u5f00\u53d1\uff0c\u671f\u5f85\u65e9\u65e5\u4e3a\u60a3\u8005\u63d0\u4f9b\u65b0\u578b\u7684\u6cbb\u7597\u9009\u62e9\u3002\u201d \u76f8\u5173\u94fe\u63a5 :&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2021090907170043603\">Read 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