{"id":42688,"date":"2021-08-31T11:09:00","date_gmt":"2021-08-31T04:09:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021083111090042688"},"modified":"2021-08-31T21:38:16","modified_gmt":"2021-08-31T13:38:16","slug":"%e5%92%8c%e9%93%82%e5%8c%bb%e8%8d%af%e5%85%ac%e5%b8%832021%e5%b9%b4%e5%8d%8a%e5%b9%b4%e5%ba%a6%e4%b8%9a%e7%bb%a9","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021083111090042688","title":{"rendered":"\u548c\u94c2\u533b\u836f\u516c\u5e032021\u5e74\u534a\u5e74\u5ea6\u4e1a\u7ee9"},"content":{"rendered":"<table border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/HB_for_email_Logo-6.jpg\" border=\"0\" alt=\"\" title=\"logo\" hspace=\"0\" vspace=\"0\" width=\"118\" 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Sinai\uff09\u8fdb\u4e00\u6b65\u63a8\u8fdb\u5b66\u672f\u5408\u4f5c\u3002<\/li>\n<\/ul>\n<p>\u548c\u94c2\u533b\u836f\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u957f\u517c\u9996\u5e2d\u6267\u884c\u5b98\u738b\u52b2\u677e\u535a\u58eb\u8868\u793a\uff1a\u201c\u548c\u94c2\u533b\u836f\u81f4\u529b\u4e8e\u4e3a\u5168\u7403\u60a3\u8005\u7814\u53d1\u521b\u65b0\u7597\u6cd5\uff0c\u6210\u4e3a\u5177\u6709\u6838\u5fc3\u6280\u672f\u4f18\u52bf\u548c\u5dee\u5f02\u5316\u4ea7\u54c1\u7ba1\u7ebf\u7684\u521b\u65b0\u751f\u7269\u5236\u836f\u516c\u53f8\u3002\u4e8c\u96f6\u4e8c\u4e00\u5e74\u4e0a\u534a\u5e74\uff0c\u516c\u53f8\u8fdb\u4e00\u6b65\u52a0\u901f\u63a8\u8fdb\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u5168\u9762\u5c55\u5f00\u6838\u5fc3\u4ea7\u54c1\u5df4\u6258\u5229\u5355\u6297\u548c\u7279\u90a3\u897f\u666e\u7684\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e76\u5f00\u59cb\u4e3a\u672a\u6765\u7684\u5546\u4e1a\u6295\u653e\u505a\u597d\u51c6\u5907\u3002\u6211\u4eec\u5c06\u7ee7\u7eed\u6295\u8d44HBM4003\u53ca\u5176\u4ed6\u7531\u6211\u4eec\u7684\u53d1\u73b0\u5f15\u64ce\u4ea7\u751f\u7684\u6f5c\u529b\u9879\u76ee\uff0c\u5e76\u5c31\u9488\u5bf9\u65b0\u9776\u70b9\u7684\u5206\u5b50\u9879\u76ee\u6216\u9488\u5bf9\u5df2\u77e5\u9776\u70b9\u7684\u521b\u65b0\u5206\u5b50\u9879\u76ee\u6df1\u5165\u63a2\u7d22\uff0c\u6301\u7eed\u53d1\u73b0\u65b0\u7684\u4f18\u8d28\u5019\u9009\u5206\u5b50\uff0c\u9884\u8ba1\u5168\u5e74\u5c06\u6709\u81f3\u5c11\u4e24\u4e2a\u65b0\u4ea7\u54c1\u7533\u62a5IND\u3002\u4e8c\u96f6\u4e8c\u4e00\u5e74\u4e0a\u534a\u5e74\u53d6\u5f97\u7684\u6210\u7ee9\u548c\u589e\u957f\u52bf\u5934\u8ba9\u6211\u4eec\u5bf9\u672a\u6765\u5145\u6ee1\u4fe1\u5fc3\uff0c\u76f8\u4fe1\u548c\u94c2\u533b\u836f\u80fd\u591f\u6210\u529f\u5e94\u5bf9\u590d\u6742\u7684\u5e02\u573a\u73af\u5883\uff0c\u5728\u4e0d\u8fdc\u7684\u672a\u6765\u4e3a\u5168\u7403\u60a3\u8005\u63d0\u4f9b\u521b\u65b0\u7684\u6cbb\u7597\u836f\u7269\u3002\u201d<\/p>\n<p><b>\u5173\u952e\u4ea7\u54c1\u5f00\u53d1\u63a5\u8fde\u5b9e\u73b0\u7a81\u7834 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HBM9161\uff09<\/b><\/p>\n<p>\u65b0\u4e00\u4ee3\u5168\u4eba\u6e90\u5355\u514b\u9686\u6297\u4f53\uff0c\u53ef\u9009\u62e9\u6027\u7ed3\u5408\u5e76\u6291\u5236\u65b0\u751f\u513f\u6676\u4f53\u7247\u6bb5\u53d7\u4f53\uff08FcRn\uff09\uff0c\u5177\u6709\u6cbb\u7597\u591a\u79cd\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u6f5c\u529b\u3002\u62a5\u544a\u671f\u5185\uff0c\u516c\u53f8\u5ba3\u5e03\u5176\u9488\u5bf9\u4e2d\u56fd\u5168\u8eab\u578b\u91cd\u75c7\u808c\u65e0\u529b\uff08gMG\uff09\u60a3\u8005\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u79ef\u6781\u7814\u7a76\u7ed3\u679c\uff0c\u8fd9\u4e5f\u662f\u6297FcRn\u7597\u6cd5\u5728\u4e2d\u56fd\u60a3\u8005\u4e2d\u7684\u9996\u4e2a\u4e34\u5e8a\u8bc1\u636e\u3002\u5df4\u6258\u5229\u5355\u6297\u8fdb\u5165\u5168\u9762\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\uff1a<\/p>\n<ul type=\"disc\">\n<li><b>\u91cd\u75c7\u808c\u65e0\u529b\uff08<\/b><b>MG\uff09<\/b> <\/li>\n<ul type=\"circle\">\n<li>\u4e8c\u96f6\u4e8c\u4e00\u5e74\u4e00\u6708\u4e2d\u56fd\u836f\u54c1\u8bc4\u5ba1\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88\u9488\u5bf9MG\u6cbb\u7597\u7684\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u8d44\u683c\u3002 <\/li>\n<li>\u4e8c\u96f6\u4e8c\u4e00\u5e74\u4e03\u6708\u53d1\u5e03MG II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u79ef\u6781\u6570\u636e\uff0c\u4f5c\u4e3a\u4e2d\u56fd\u9996\u4e2a\u6297FcRn\u7597\u6cd5\u7684\u4e34\u5e8a\u8bc1\u636e\uff0c\u8be5\u8bd5\u9a8c\u663e\u793a\u4e86\u5df4\u6258\u5229\u5355\u6297\u76f8\u5bf9\u4e8e\u5b89\u6170\u5242\u7684\u7edf\u8ba1\u5b66\u548c\u4e34\u5e8a\u610f\u4e49\uff0c\u4ee5\u53ca\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002 <\/li>\n<li>\u4e0eNMPA CDE\u6210\u529f\u4e3e\u884cII\u671f\u7ed3\u675f\u4f1a\u8bae\uff0c\u4f1a\u8bae\u671f\u95f4\uff0cCDE\u8868\u793a\u5c06\u5bf9III\u671f\u7814\u7a76\u7ed9\u4e88\u5168\u529b\u652f\u6301\u3002 <\/li>\n<li>\u8ba1\u5212\u4e8e\u4e8c\u96f6\u4e8c\u4e00\u5e74\u4e0b\u534a\u5e74\u542f\u52a8MG\u7684III\u671f\u7814\u7a76\uff0c\u5e76\u4e8e\u4e8c\u96f6\u4e8c\u4e8c\u5e74\u63d0\u4ea4BLA\u7533\u8bf7<\/li>\n<\/ul>\n<li><b>\u89c6\u795e\u7ecf\u810a\u9ad3\u708e\u8c31\u7cfb\u75be\u75c5\uff08<\/b><b>NMOSD\uff09<\/b> <\/li>\n<ul type=\"circle\">\n<li>\u4e8c\u96f6\u4e8c\u4e00\u5e74\u4e03\u6708\u5b8c\u6210NMOSD Ib\/IIa\u671f\u4e34\u5e8a\u8bd5\u9a8c\u75c5\u4eba\u5165\u7ec4\u3002 <\/li>\n<li>\u8ba1\u5212\u4e8e\u4e8c\u96f6\u4e8c\u4e00\u5e74\u4e0b\u534a\u5e74\u83b7\u5f97Ib\/IIa\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6570\u636e\u5206\u6790\uff0c\u5e76\u4e8e\u4e8c\u96f6\u4e8c\u4e00\u5e74\u5e95\u5f00\u59cb\u5173\u952e\u8bd5\u9a8c\u7684\u76d1\u7ba1\u6c9f\u901a\u3002 <\/li>\n<li>\u8ba1\u5212\u4e8e\u4e8c\u96f6\u4e8c\u4e8c\u5e74\u63d0\u4ea4BLA\u7533\u8bf7<\/li>\n<\/ul>\n<li><b>\u514d\u75ab\u6027\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\uff08<\/b><b>ITP\uff09<\/b> <\/li>\n<ul type=\"circle\">\n<li>\u4e8c\u96f6\u4e8c\u4e00\u5e74\u4e0a\u534a\u5e74\u5b8c\u6210II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e76\u8ba1\u5212\u4e8e\u4e8c\u96f6\u4e8c\u4e00\u5e74\u4e0b\u534a\u5e74\u8fdb\u884c\u6570\u636e\u5206\u6790\u3002 <\/li>\n<li>\u4e8c\u96f6\u4e8c\u4e00\u5e74\u4e8c\u6708\u83b7\u5f97NMPA\u6279\u51c6\u9488\u5bf9ITP\u60a3\u8005\u65b0\u5242\u91cf\u65b9\u6848\u4e34\u5e8a\u8bd5\u9a8c\u6279\u4ef6\u3002 <\/li>\n<li>\u8ba1\u5212\u4e8e\u4e8c\u96f6\u4e8c\u4e09\u5e74\u63d0\u4ea4BLA\u7533\u8bf7<\/li>\n<\/ul>\n<li><b>\u7532\u72b6\u817a\u76f8\u5173\u6027\u773c\u75c5\uff08<\/b><b>GO\uff09<\/b> <\/li>\n<ul type=\"circle\">\n<li>\u8ba1\u5212\u4e8e\u4e8c\u96f6\u4e8c\u4e00\u5e74\u4e0b\u534a\u5e74\u542f\u52a8GO II\/III\u671f\u6ce8\u518c\u8bd5\u9a8c\uff0c\u5e76\u4e8e\u4e8c\u96f6\u4e8c\u4e09\u5e74\u63d0\u4ea4BLA\u7533\u8bf7<\/li>\n<\/ul>\n<li><b>\u5176\u4ed6\u9002\u5e94\u75c7<\/b> <\/li>\n<ul type=\"circle\">\n<li>\u4e8c\u96f6\u4e8c\u4e00\u5e74\u4e94\u6708\u5411NMPA\u63d0\u4ea4\u9488\u5bf9\u6162\u6027\u708e\u6027\u8131\u9ad3\u9798\u6027\u591a\u53d1\u6027\u795e\u7ecf\u6839\u795e\u7ecf\u75c5\uff08CIDP\uff09\u9002\u5e94\u75c7\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u3002 <\/li>\n<li>\u4e8c\u96f6\u4e8c\u4e00\u5e74\u516b\u6708\u5411NMPA\u63d0\u4ea4\u9488\u5bf9\u5929\u75b1\u75ae\uff08PV\uff09\u9002\u5e94\u75c7\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u3002<\/li>\n<\/ul>\n<\/ul>\n<p><b>\u7279\u90a3\u897f\u666e <\/b><b>(Tanfanercept HBM9036\uff09<\/b><\/p>\n<p>\u76ee\u524d\u516c\u53f8\u5f00\u53d1\u7684\u6700\u524d\u6cbf\u5019\u9009\u4ea7\u54c1\uff0c\u9002\u7528\u4e8e\u6cbb\u7597\u4e2d\u91cd\u5ea6\u5e72\u773c\uff08DED\uff09\uff0c\u53ef\u6ee1\u8db3\u4e2d\u56fd\u5e02\u573a\u7684\u5de8\u5927\u4e34\u5e8a\u9700\u6c42\u3002<\/p>\n<ul type=\"disc\">\n<li>\u4e8c\u96f6\u4e8c\u4e00\u5e74\u4e09\u6708\u5b8c\u6210\u6b63\u5728\u8fdb\u884c\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u9996\u6b21\u7ed9\u836f\u3002 <\/li>\n<li>\u8ba1\u5212\u4e8e\u4e8c\u96f6\u4e8c\u4e8c\u5e74\u63d0\u4ea4BLA\u7533\u8bf7\u3002<\/li>\n<\/ul>\n<p><b>HBM4003<\/b><\/p>\n<p>HBM4003\u662f\u4e00\u6b3e\u4ea7\u751f\u4e8e\u548c\u94c2\u533b\u836f\u7279\u6709\u7684HCAb\u4e13\u5229\u6280\u672f\u5e73\u53f0\u7684\u65b0\u4e00\u4ee3\u6297CTLA-4\u5168\u4eba\u6e90\u91cd\u94fe\u6297\u4f53\uff0c\u4ea6\u662f\u5168\u7403\u5386\u53f2\u4e0a\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u7684\u5168\u4eba\u6e90\u91cd\u94fe\u6297\u4f53\u3002\u4e8c\u96f6\u4e8c\u4e00\u5e74\uff0c\u548c\u94c2\u533b\u836f\u5f00\u5c55\u4e86HBM4003\u9488\u5bf9\u591a\u79cd\u5b9e\u4f53\u7624\u6cbb\u7597\u65b9\u6848\u8bbe\u8ba1\u7684\u5168\u7403\u5f00\u53d1\u8ba1\u5212\u3002<\/p>\n<ul type=\"disc\">\n<li>\u4e8c\u96f6\u4e8c\u4e00\u5e74\u4e8c\u6708\u83b7\u5f97NMPA\u6279\u51c6\u4e0ePD-1\/\u5316\u7597\u8054\u5408\u7528\u4e8e\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u53ca\u5176\u4ed6\u665a\u671f\u5b9e\u4f53\u7624\u7684\u4e34\u5e8a\u7814\u7a76\u6279\u4ef6\u3002 <\/li>\n<li>\u5b8c\u6210\u6fb3\u5927\u5229\u4e9a\u5355\u836f\u6cbb\u7597I\u671f\u4e34\u5e8a\u9996\u4e2a\u8bd5\u9a8c\u6570\u636e\u8bfb\u51fa\uff0c\u53d6\u5f97\u4e86\u4ee4\u4eba\u632f\u594b\u7684\u7ed3\u679c\u3002\u8be5\u7814\u7a76\u6210\u679c\u5c06\u4ee5\u7535\u5b50\u6d77\u62a5\u7684\u5f62\u5f0f\u5728\u4e8c\u96f6\u4e8c\u4e00\u5e74\u4e5d\u6708\u7684\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\uff08ESMO\uff09\u5e74\u4f1a\u671f\u95f4\u516c\u5e03\u3002 <\/li>\n<li>\u4e8c\u96f6\u4e8c\u4e00\u5e74\u4e94\u6708\u5b8c\u6210\u5355\u836f\u6cbb\u7597I\u671f\u8bd5\u9a8c\u7b2c2\u90e8\u5206\/\u5242\u91cf\u6269\u5c55\u4e34\u5e8a\u8bd5\u9a8c\u7684\u9996\u6b21\u7ed9\u836f\u3002 <\/li>\n<li>\u4e8c\u96f6\u4e8c\u4e00\u5e74\u4e09\u6708\u5b8c\u6210\u9488\u5bf9\u4e2d\u56fd\u665a\u671f\u9ed1\u8272\u7d20\u7624\u548c\u5176\u4ed6\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u7684PD-1\u8054\u5408\u6cbb\u7597I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u9996\u6b21\u7ed9\u836f\u3002 <\/li>\n<li>\u4e8c\u96f6\u4e8c\u4e00\u5e74\u516d\u6708\u5b8c\u6210\u9488\u5bf9\u4e2d\u56fd\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u548c\u5176\u4ed6\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u7684PD-1\/\u5316\u7597\u8054\u5408\u6cbb\u7597I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u9996\u6b21\u7ed9\u836f\u3002 <\/li>\n<li>\u4e8c\u96f6\u4e8c\u4e00\u5e74\u516d\u6708\u63d0\u4ea4\u9488\u5bf9\u4e0ePD-1\u8054\u5408\u6cbb\u7597\u4e24\u9879\u65b0\u9002\u5e94\u75c7 &#8212; \u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u548c\u795e\u7ecf\u5185\u5206\u6ccc\u80bf\u7624\uff08NEN\uff09\u7684\u4e34\u5e8a\u7533\u8bf7\u3002\u9884\u8ba1\u5c06\u4e8e\u4e8c\u96f6\u4e8c\u4e00\u5e74\u4e0b\u534a\u5e74\u83b7\u5f97\u6279\u51c6\uff0c\u5e76\u4e8e\u4e8c\u96f6\u4e8c\u4e8c\u5e74\u521d\u5f00\u59cb\u60a3\u8005\u7ed9\u836f\u3002 <\/li>\n<\/ul>\n<p><b>\u591a\u4e2a\u6f5c\u529b\u9879\u76ee\u52a0\u901f\u5411\u524d\uff0c\u63a5\u8fd1\u4e34\u5e8a\u5f00\u53d1 <\/b><\/p>\n<p>\u9664\u4e0a\u8ff0\u4ea7\u54c1\u5916\uff0c\u548c\u94c2\u533b\u836f\u8fd8\u6709\u591a\u4e2a\u6f5c\u529b\u9879\u76ee\u6b63\u52a0\u901f\u5411\u524d\uff0c\u5305\u62ecHBM7008\u3001HBM9378\u3001HBM1022\u3001HBM1020\u3001HBM7020\u3001HBM7015\u3001HBM1007\u3001HBM1029\u7b49\uff0c\u5747\u5df2\u63a5\u8fd1\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u3002\u672a\u6765\uff0c\u548c\u94c2\u533b\u836f\u8ba1\u5212\u6bcf\u5e74\u63d0\u4ea4\u4e24\u4e2a\u6216\u66f4\u591a\u7531\u516c\u53f8\u53d1\u73b0\u5f15\u64ce\u4ea7\u751f\u7684\u65b0\u836fIND\u7533\u8bf7\uff0c\u771f\u6b63\u5b9e\u73b0\u521b\u65b0\u836f\u7269\u7814\u53d1\u7684\u5feb\u901f\u62d3\u5c55\u3002<\/p>\n<p><b>HBM7008<\/b><\/p>\n<p>HBM7008\u4e3a\u4e00\u79cd\u9488\u5bf9\u80bf\u7624\u76f8\u5173\u6297\u539f(B7H4)x4-1BB\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u57fa\u4e8e\u548c\u94c2\u533b\u836f\u7684\u91cd\u94fe\u6297\u4f53\u514d\u75ab\u7ec6\u80de\u8854\u63a5\u5668\u53cc\u6297\u5e73\u53f0\uff08HBICE<sup>&reg;<\/sup>\uff09\u5f00\u53d1\u800c\u6210\uff0c\u662f\u76ee\u524d\u5168\u7403\u9488\u5bf9\u8fd9\u4e24\u4e2a\u9776\u70b9\u7684\u552f\u4e00\u53cc\u6297\u3002\u9884\u671f\u5c06\u4e8e\u4e8c\u96f6\u4e8c\u4e00\u5e74\u63d0\u4ea4CTA\/IRB\u7533\u8bf7\u3002<\/p>\n<p><b>HBM9378<\/b><\/p>\n<p>HBM9378\u662f\u4e00\u6b3e\u7531\u548c\u94c2\u533b\u836fH2L2\u5e73\u53f0\u4ea7\u751f\u7684\u5168\u4eba\u6e90\u5355\u514b\u9686\u6297\u4f53\uff0c\u5177\u6709\u66f4\u4f4e\u7684\u514d\u75ab\u539f\u6027\u98ce\u9669\uff0c\u4e0e\u540c\u9776\u70b9\u7ade\u4e89\u8005\u76f8\u6bd4\u4e5f\u5177\u6709\u66f4\u597d\u7684\u751f\u7269\u5229\u7528\u5ea6\u3002\u8f83\u957f\u7684\u534a\u8870\u671f\u4f18\u5316\u8bbe\u8ba1\u548c\u4f18\u79c0\u7684\u7406\u5316\u6027\u8d28\u4f7f\u5f97HBM9378\u5728\u7ed9\u836f\u548c\u5242\u578b\u65b9\u9762\u62e5\u6709\u6f5c\u5728\u4f18\u52bf\u3002\u9884\u671f\u5c06\u4e8e\u4e8c\u96f6\u4e8c\u4e00\u5e74\u5e95\u63d0\u4ea4IND\u7533\u8bf7\u3002<\/p>\n<p><b>HBM1022<\/b><\/p>\n<p>HBM1022\u662f\u548c\u94c2\u533b\u836f\u5f00\u53d1\u7684\u4e00\u79cdCCR8\u6297\u4f53\uff0c\u4e0e\u98df\u87f9\u7334\u7684CCR8\u9776\u70b9\u4ea4\u53c9\u53cd\u5e94\uff0c\u5e76\u5728\u5c0f\u9f20\u80bf\u7624\u6a21\u578b\u4e2d\u663e\u793a\u4e86\u5176\u663e\u8457\u7684\u80bf\u7624\u751f\u957f\u6291\u5236\u6548\u679c\u3002\u76ee\u524d\uff0c\u9488\u5bf9CCR8\u8fd9\u4e00\u521b\u65b0\u9776\u70b9\u7684\u836f\u7269\u5728\u5168\u7403\u8303\u56f4\u5185\u5c1a\u672a\u6709\u516c\u53f8\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u3002\u9884\u671f\u5c06\u4e8e\u4e8c\u96f6\u4e8c\u4e8c\u5e74\u63d0\u4ea4IND\u7533\u8bf7\u3002<\/p>\n<p><b>HBM1020<\/b><\/p>\n<p>HBM1020\u662f\u4e00\u6b3e\u7531\u548c\u94c2\u533b\u836fH2L2\u5e73\u53f0\u4ea7\u751f\u7684\u5168\u4eba\u6e90\u5355\u514b\u9686\u6297\u4f53\u3002\u8be5\u6297\u4f53\u9488\u5bf9\u4e8eB7\u5bb6\u65cf\u7684\u5168\u65b0\u9776\u70b9\uff0c\u901a\u8fc7\u963b\u65ad\u9776\u70b9\u548c\u914d\u4f53\u7684\u7ed3\u5408\uff0c\u80fd\u591f\u589e\u5f3a\u6297\u80bf\u7624\u7684\u514d\u75ab\u53cd\u5e94\u3002\u4e34\u5e8a\u524d\u8d44\u6599\u5df2\u8bc1\u5b9e\u4e86\u5176\u514d\u75ab\u542f\u52a8\u548c\u6297\u80bf\u7624\u7684\u529f\u80fd\u6d3b\u6027\u3002\u9884\u671f\u5c06\u4e8e\u4e8c\u96f6\u4e8c\u4e8c\u5e74\u63d0\u4ea4IND\u7533\u8bf7\u3002<\/p>\n<p><b>HBM1007<\/b><\/p>\n<p>HBM1007\u662f\u4e00\u6b3e\u7531\u548c\u94c2\u533b\u836fH2L2\u5e73\u53f0\u4ea7\u751f\u7684\u5bf9\u6297CD73\u7684\u5168\u4eba\u6e90\u5355\u514b\u9686\u6297\u4f53\uff0c\u4e3a\u4e00\u79cd\u5728\u57fa\u8d28\u7ec6\u80de\u53ca\u80bf\u7624\u8868\u8fbe\u7684\u53ef\u5c06\u80de\u5916\u817a\u82f7\u5355\u78f7\u9178\uff08AMP\uff09\u8f6c\u5316\u4e3a\u817a\u82f7\u7684\u80de\u5916\u9176\u3002HBM1007\u6b63\u5904\u4e8e\u4e34\u5e8a\u524d\u9636\u6bb5\u7684\u7814\u7a76\uff0c\u9884\u671f\u5c06\u4e8e\u4e8c\u96f6\u4e8c\u4e8c\u5e74\u63d0\u4ea4IND\u7533\u8bf7\u3002<\/p>\n<p><b>HBM7020\u3001HBM1029\u53caHBM7015<\/b><\/p>\n<p>HBM7020\u662f\u4e00\u6b3e\u5229\u7528\u548c\u94c2\u533b\u836fHBICE<sup>&reg;<\/sup>\u6280\u672f\u5e73\u53f0\u5f00\u53d1\u7684BCMAxCD3\u53cc\u7279\u5f02\u6027\u6297\u4f53\u3002HBM1029\u662f\u4e00\u6b3e\u7531\u548c\u94c2\u533b\u836fH2L2\u5e73\u53f0\u5f00\u53d1\u7684\u5177\u5907\u66f4\u9ad8\u7684CLDN18.2\u7ed3\u5408\u4eb2\u548c\u529b\uff0c\u4ee5\u53ca\u8f83\u5f3a\u7684ADCC\u53caCDC\u6297\u80bf\u7624\u6d3b\u529b\u7684\u5355\u514b\u9686\u6297\u4f53\u3002HBM7015\u662f\u4e00\u79cd\u81eaH2L2\u5e73\u53f0\u4ea7\u751f\u7684\u6291\u5236PD-L1\u7684\u53cc\u529f\u80fd\u878d\u5408\u86cb\u767d\u3002<\/p>\n<p>\u4e8c\u96f6\u4e8c\u96f6\u5e74\uff0c\u548c\u94c2\u533b\u836f\u5c06\u81ea\u4e3b\u6280\u672f\u5e73\u53f0\u5f00\u53d1\u7684\u8fd9\u4e09\u4e2a\u4e34\u5e8a\u524d\u4ea7\u54c1\uff08HBM7020\u3001HBM1029\u53caHBM7015\uff09\u7684\u5927\u4e2d\u534e\u533a\u6743\u76ca\u6388\u6743\u7ed9\u4e2d\u56fd\u751f\u7269\u5236\u836f\u4f01\u4e1a\u534e\u5170\u57fa\u56e0\u3002\u5728\u5b8c\u6210\u6280\u672f\u8f6c\u8ba9\u540e\uff0c\u4e24\u5bb6\u516c\u53f8\u5171\u540c\u63a8\u52a8\u8fd9\u4e09\u4e2a\u9879\u76ee\u7684\u5f00\u53d1\u3002\u9884\u671f\u5c06\u4e8e\u4e8c\u96f6\u4e8c\u4e8c\u5e74\u76f8\u7ee7\u63d0\u4ea4IND\u7533\u8bf7\u3002<\/p>\n<p><b>\u4e13\u4e1a\u56e2\u961f\u7194\u94f8\u5f3a\u5927\u7814\u53d1\u5b9e\u529b \u6253\u9020\u5168\u7403\u521b\u65b0\u9ad8\u5730<\/b><\/p>\n<p>\u548c\u94c2\u533b\u836f\u4e13\u6ce8\u4e8e\u514d\u75ab\u4e0e\u80bf\u7624\u514d\u75ab\u9886\u57df\u7684\u65b0\u4e00\u4ee3\u521b\u65b0\u578b\u7597\u6cd5\uff0c\u836f\u7269\u53d1\u73b0\u53ca\u4e34\u5e8a\u524d\u7814\u7a76\u56e2\u961f\u5c31\u65b0\u5019\u9009\u836f\u7269\u8fdb\u884c\u836f\u7269\u53d1\u73b0\u3001\u5236\u5242\u7814\u5236\u3001\u5de5\u827a\u5f00\u53d1\u53ca\u4e34\u5e8a\u524d\u7814\u7a76\u3002\u540c\u65f6\uff0c\u516c\u53f8\u7684\u4e13\u4e1a\u79d1\u5b66\u5bb6\u56e2\u961f\uff0c\u5bf9\u6211\u4eec\u7684\u6280\u672f\u5e73\u53f0\u8fdb\u884c\u6301\u7eed\u4f18\u5316\u3001\u5347\u7ea7\u53ca\u518d\u5f00\u53d1\u3002<\/p>\n<p>\u62a5\u544a\u671f\u5185\uff0c\u516c\u53f8\u5728\u836f\u7269\u53d1\u73b0\u3001\u6280\u672f\u5e73\u53f0\u53ca\u4e13\u5229\u65b9\u9762\u53d6\u5f97\u7684\u4e3b\u8981\u8fdb\u5c55\u5982\u4e0b\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u5171\u7533\u8bf7\u4e13\u5229\u8fbe28\u9879\uff0c\u5176\u4e2d4\u9879\u5df2\u7ecf\u83b7\u5f97\u76f8\u5173\u56fd\u5bb6\u6216\u5730\u533a\u7684\u53d1\u660e\u4e13\u5229\u6388\u6743\uff0c\u8fdb\u4e00\u6b65\u52a0\u5f3a\u5bf9\u516c\u53f8\u6838\u5fc3\u4ea7\u54c1\u548c\u6280\u672f\u5e73\u53f0\u7684\u77e5\u8bc6\u4ea7\u6743\u4fdd\u62a4\u3002 <\/li>\n<li>\u5f00\u53d1\u5e76\u4e8e\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\uff08AACR\uff09\u5e74\u4f1a\u4e0a\u53d1\u5e03\u4e00\u6b3e\u65b0\u53d1\u73b0\u5168\u4eba\u6e90\u6297B7H7\u5355\u514b\u9686\u6297\u4f53 &#8212; HBM1020\u3002 <\/li>\n<li>\u5f00\u53d1\u5e76\u4e8e\u6297\u4f53\u5de5\u7a0b\u548c\u6cbb\u7597\uff08AET\uff09\u5927\u4f1a\u5c55\u793a\u4e00\u6b3e\u5168\u65b0\u53cc\u7279\u5f02\u6027\u6297\u4f53 &#8212; HBM7022\uff08CLDN18.2xCD3\uff09\u3002&nbsp;<\/li>\n<\/ul>\n<p>\u548c\u94c2\u533b\u836f\u5df2\u7ecf\u5efa\u7acb\u8d77\u5f3a\u5927\u7684\u6297\u4f53\u53d1\u73b0\u5e73\u53f0\u548cGPCR\u836f\u7269\u5f00\u53d1\u5e73\u53f0\uff0c\u57fa\u4e8e\u8fd9\u4e9b\u6280\u672f\u5e73\u53f0\uff0c\u516c\u53f8\u6709\u671b\u5411\u5168\u7403\u8303\u56f4\u5185\u66f4\u591a\u7684\u521b\u65b0\u53ca\u9ad8\u96be\u5ea6\u836f\u7269\u9776\u70b9\u8fc8\u8fdb\u3002<\/p>\n<p><b>\u5f3a\u5316\u5168\u7403\u5408\u4f5c \u91ca\u653e\u5e73\u53f0\u4ef7\u503c<\/b><\/p>\n<p>\u62a5\u544a\u671f\u5185\uff0c\u548c\u94c2\u533b\u836f\u7ee7\u7eed\u6269\u5927\u4e0e\u5168\u7403\u9886\u5148\u5b66\u672f\u673a\u6784\u7684\u4e1a\u52a1\u5408\u4f5c\u5e76\u7cbe\u9009\u4e13\u6ce8\u4e8e\u521b\u65b0\u548c\u6548\u7387\u7684\u4ea7\u4e1a\u4f19\u4f34\u3002\u51ed\u501f\u4e13\u6709\u6280\u672f\u548c\u5f3a\u5927\u7684\u5185\u90e8\u7814\u53d1\u80fd\u529b\u5efa\u7acb\u7684\u7075\u6d3b\u5546\u4e1a\u6a21\u5f0f\uff0c\u548c\u94c2\u533b\u836f\u51dd\u805a\u81ea\u8eab\u5b9e\u529b\u53ca\u5176\u5408\u4f5c\u4f19\u4f34\u7684\u4e92\u8865\u4f18\u52bf\uff0c\u6301\u7eed\u91ca\u653e\u5e73\u53f0\u4ef7\u503c\u3002<\/p>\n<ul type=\"disc\">\n<li>\u4e8c\u96f6\u4e8c\u4e00\u5e74\u4e94\u6708\u4e0e\u767e\u56fe\u751f\u79d1\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u534f\u8bae\uff0c\u4ee5Harbour Mice<sup>&reg;<\/sup>\u5e73\u53f0\u4e3a\u57fa\u7840\uff0c\u6574\u5408\u767e\u56fe\u751f\u79d1\u5728\u4eba\u5de5\u667a\u80fd\u6280\u672f\u65b9\u9762\u7684\u4f18\u52bf\uff0c\u81f4\u529b\u4e8e\u65b0\u578b\u6297\u4f53\u4ea7\u54c1\u7684\u79d1\u7814\u3001\u5f00\u53d1\u548c\u8f6c\u5316\u3002 <\/li>\n<li>\u4e8c\u96f6\u4e8c\u4e00\u5e74\u516d\u6708\u4e0e\u54c8\u4f5b\u533b\u5b66\u9662\u9644\u5c5e\u533b\u9662\u4e39\u5a1c-\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute, DFCI\uff09\u8fbe\u6210\u4e00\u9879\u4e3a\u671f\u591a\u5e74\u3001\u6d89\u53ca\u591a\u65b9\u9762\u7684\u7814\u7a76\u5408\u4f5c\u534f\u8bae\uff0c\u5171\u540c\u63a8\u8fdb\u80bf\u7624\u6cbb\u7597\u521b\u65b0\u578b\u751f\u7269\u7597\u6cd5\u7684\u7814\u53d1\uff0c\u5305\u62ec\u53cc\u7279\u5f02\u6027\u6297\u4f53\u53caCAR-T\u7ec6\u80de\u4ea7\u54c1\u7b49\u3002 <\/li>\n<li>\u4e0e\u897f\u5948\u5c71\u4f0a\u574e\u533b\u5b66\u9662\uff08Mount Sinai\uff09\u8fdb\u4e00\u6b65\u63a8\u8fdb\u5b66\u672f\u5408\u4f5c\u3002\u897f\u5948\u5c71\u4f0a\u574e\u533b\u5b66\u9662\u4e0e\u7b2c\u4e09\u65b9\u5c31Harbour Mice<sup>&reg;<\/sup>\u5e73\u53f0\u4e0a\u751f\u6210\u7684\u5177\u6709SARS-COVID-2\uff08COVID-19\uff09\u6291\u5236\u7279\u6027\u7684\u6297\u4f53\u8d44\u4ea7\u8fbe\u6210\u72ec\u5bb6\u6388\u6743\u534f\u8bae\u3002<\/li>\n<\/ul>\n<p><b>\u6784\u5efa\u5185\u90e8\u751f\u4ea7\u80fd\u529b\u652f\u6301\u4e34\u5e8a\u5f00\u53d1 \u642d\u5efa\u5546\u4e1a\u5316\u56e2\u961f\u52a9\u529b\u4ea7\u54c1\u4e0a\u5e02<\/b><\/p>\n<p>\u968f\u7740\u548c\u94c2\u533b\u836f\u4e34\u5e8a\u524d\u4ea7\u54c1\u7684\u4e0d\u65ad\u6210\u719f\uff0c\u516c\u53f8\u6b63\u9010\u6b65\u53d1\u5c55\u5185\u90e8\u751f\u4ea7\u80fd\u529b\u3001\u4ea7\u80fd\u53ca\u5546\u4e1a\u5316\u56e2\u961f\u3002<\/p>\n<ul type=\"disc\">\n<li>\u4e8c\u96f6\u4e8c\u4e00\u5e74\u542f\u52a8\u4e34\u5e8a\u4f9b\u5e94\u751f\u4ea7\u8bbe\u65bd\u9879\u76ee\uff0c\u4ee5\u652f\u6301\u4ea7\u54c1\u7ba1\u7ebf\u9879\u76ee\u7684\u4e34\u5e8a\u5f00\u53d1\u3002\u8be5\u4e2d\u8bd5\u751f\u4ea7\u8bbe\u65bd\u4f4d\u4e8e\u6c5f\u82cf\u7701\u82cf\u5dde\u5e02\uff0c\u4f7f\u7528\u9762\u79ef\u7ea68500\u5e73\u65b9\u7c73\uff0c\u8bbe\u8ba1\u751f\u4ea7\u89c4\u6a21\u53ef\u8fbe4000\u5347\u3002\u968f\u7740\u516c\u53f8CMC\u56e2\u961f\u7684\u5feb\u901f\u7ec4\u5efa\uff0c\u8be5\u5de5\u5382\u9884\u8ba1\u5c06\u4e8e\u4e8c\u96f6\u4e8c\u4e8c\u5e74\u6295\u5165\u751f\u4ea7\u3002 <\/li>\n<li>\u516c\u53f8\u5df2\u5f00\u59cb\u7ec4\u5efa\u4e00\u652f\u5728\u9500\u552e\u3001\u5e02\u573a\u8425\u9500\u548c\u5e02\u573a\u51c6\u5165\u65b9\u9762\u5177\u6709\u6df1\u539a\u77e5\u8bc6\u3001\u7ecf\u9a8c\u548c\u4e13\u957f\u7684\u5546\u4e1a\u5316\u56e2\u961f\u3002\u62a5\u544a\u671f\u5185\uff0c\u5546\u4e1a\u5316\u56e2\u961f\u5df2\u7ecf\u542f\u52a8\u76f8\u5173\u5de5\u4f5c\uff0c\u4e3a\u672a\u6765\u9886\u5148\u4ea7\u54c1\u7684\u4e0a\u5e02\u505a\u597d\u51c6\u5907\uff0c\u4e3a\u672a\u6765\u7684\u5546\u4e1a\u5b66\u672f\u63a8\u5e7f\u53ca\u7ba1\u7ebf\u62d3\u5c55\u6253\u597d\u57fa\u7840\u3002<\/li>\n<\/ul>\n<p><b>2021\u5e74\u4e0a\u534a\u5e74\u8d22\u52a1\u4e1a\u7ee9\uff1a\u6301\u7eed\u6536\u5165\u4f53\u73b0\u5e73\u53f0\u4ef7\u503c \u7b03\u5fd7\u7814\u53d1\u63a8\u8fdb\u836f\u7269\u7ba1\u7ebf<\/b><\/p>\n<p>\u622a\u81f3\u4e8c\u96f6\u4e8c\u4e00\u5e74\u516d\u6708\u4e09\u5341\u65e5\u6b62\u534a\u5e74\u5ea6\uff0c\u516c\u53f8\u6536\u51652.2\u767e\u4e07\u7f8e\u5143\uff0c\u4e3b\u8981\u6765\u81ea\u4e8e\u5206\u5b50\u8bb8\u53ef\u8d39\u3002<\/p>\n<p>\u622a\u81f3\u4e8c\u96f6\u4e8c\u4e00\u5e74\u516d\u6708\u4e09\u5341\u65e5\u6b62\u534a\u5e74\u5ea6\uff0c\u516c\u53f8\u7684\u5176\u5b83\u6536\u5165\u53ca\u6536\u76ca\u4e3a2.7\u767e\u4e07\u7f8e\u5143\uff0c\u4e3b\u8981\u6765\u81ea\u94f6\u884c\u5229\u606f\u6536\u5165\u589e\u52a0\u3001\u653f\u5e9c\u8865\u8d34\u53ca\u5916\u6c47\u6536\u76ca\u51c0\u989d\u53d8\u52a8\u3002<\/p>\n<p>\u622a\u81f3\u4e8c\u96f6\u4e8c\u4e00\u5e74\u516d\u6708\u4e09\u5341\u65e5\u6b62\u534a\u5e74\u5ea6\uff0c\u516c\u53f8\u7684\u7814\u53d1\u5f00\u652f\u4e3a41.2\u767e\u4e07\u7f8e\u5143\uff0c\u7814\u53d1\u4eba\u5458\u53ca\u5176\u80a1\u4efd\u8d39\u7528\u589e\u52a0\uff0c\u9884\u4ed8\u53ca\u91cc\u7a0b\u7891\u8d39\u7528\u589e\u52a0\uff0c\u4ee5\u53ca\u53d1\u73b0\u548c\u4e34\u5e8a\u9636\u6bb5\u7684\u5206\u5b50\u8d44\u4ea7\u589e\u52a0\u3002<\/p>\n<p><b>\u5173\u4e8e<\/b><b>HBM4003<br \/><\/b>HBM4003\u662f\u4eceHarbor Mice<sup>&reg;<\/sup>\u53d1\u73b0\u53ca\u5f00\u53d1\u7684\u65b0\u4e00\u4ee3\u5168\u4eba\u6e90\u4ec5\u91cd\u94fe\u6297CTLA-4\u6297\u4f53\u3002HBM4003\u4e3a\u9996\u4e2a\u901a\u8fc7HCAb\u5e73\u53f0\u4ea7\u751f\u7684\u5185\u90e8\u5f00\u53d1\u5206\u5b50\uff0c\u5728\u4e09\u5e74\u5185\u5df2\u4ece\u5019\u9009\u836f\u7269\u7b5b\u9009\u9636\u6bb5\u63a8\u8fdb\u81f3\u4e34\u5e8a\u9636\u6bb5\u3002HBM4003\u662f\u5386\u53f2\u4e0a\u5168\u7403\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u7684\u6297CTLA-4\u5168\u4eba\u6e90\u91cd\u94fe\u6297\u4f53\u3002\u76f8\u8f83\u4f20\u7edf\u7684\u6297CTLA-4\u6297\u4f53\uff0cHBM4003\u5177\u6709\u663e\u8457\u589e\u52a0\u7684T\u8c03\u8282\u6027\u7ec6\u80de\u5254\u9664\u673a\u7406\u548c\u6539\u5584\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\uff0c\u4ece\u800c\u6709\u671b\u7a81\u7834\u73b0\u6709\u5206\u5b50\u7684\u7597\u6548\u5b89\u5168\u6027\u74f6\u9888\uff0c\u6210\u4e3a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u9886\u57df\u7684\u6838\u5fc3\u4ea7\u54c1\u3002<\/p>\n<p><b>\u5173\u4e8e\u7279\u90a3\u897f\u666e\uff08<\/b><b>HBM9036\uff09<br \/><\/b>\u7279\u90a3\u897f\u666e\uff08HBM9036\uff09\u662f\u548c\u94c2\u533b\u836f\u5f00\u53d1\u6700\u524d\u6cbf\u7684\u5019\u9009\u4ea7\u54c1\uff0c\u9002\u7528\u4e8e\u6cbb\u7597\u4e2d\u91cd\u5ea6\u5e72\u773c\uff08DED\uff09\u3002\u7279\u90a3\u897f\u666e\u7684\u4f5c\u7528\u673a\u5236\u4e3a\u6291\u5236\u4f1a\u5bfc\u81f4\u773c\u775b\u53d1\u708e\u7684\u80bf\u7624\u574f\u6b7b\u56e0\u5b50TNF-\u03b1\u3002\u5728\u4e2d\u56fd\u53d1\u5c55\u8fc5\u901f\u7684\u5e72\u773c\u836f\u7269\u5e02\u573a\u4e2d\uff0c\u7279\u90a3\u897f\u666e\u6709\u6f5c\u529b\u4e89\u53d6\u7edd\u5927\u90e8\u5206\u5e02\u573a\u4efd\u989d\u3002<\/p>\n<p><b>\u5173\u4e8e\u5df4\u6258\u5229\u5355\u6297\uff08<\/b><b>HBM9161\uff09<br \/><\/b>\u5df4\u6258\u5229\u5355\u6297\uff08HBM9161\uff09\u662f\u4e00\u79cd\u65b0\u578b\u7684\u5168\u4eba\u6e90\u5355\u514b\u9686\u6297\u4f53\uff0c\u53ef\u9009\u62e9\u6027\u7ed3\u5408\u5e76\u6291\u5236\u65b0\u751f\u513f\u6676\u4f53\u7247\u6bb5\u53d7\u4f53\uff08FcRn\uff09\u3002\u4f5c\u4e3a\u5927\u4e2d\u534e\u533a\u4e34\u5e8a\u5f00\u53d1\u6700\u524d\u6cbf\u7684FcRn\u6291\u5236\u5242\uff0c\u5df4\u6258\u5229\u5355\u6297\u6709\u6f5c\u529b\u6210\u4e3a\u5927\u4e2d\u534e\u533a\u591a\u79cd\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u7a81\u7834\u6027\u7597\u6cd5\u3002<\/p>\n<p><b>\u5173\u4e8e\u548c\u94c2\u533b\u836f<br \/><\/b>\u548c\u94c2\u533b\u836f\uff08\u80a1\u7968\u4ee3\u7801\uff1a02142.HK\uff09\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u80bf\u7624\u53ca\u514d\u75ab\u6027\u75be\u75c5\u9886\u57df\u521b\u65b0\u836f\u7814\u53d1\u53ca\u5546\u4e1a\u5316\u7684\u5168\u7403\u5316\u751f\u7269\u5236\u836f\u4f01\u4e1a\u3002\u516c\u53f8\u901a\u8fc7\u81ea\u4e3b\u7814\u53d1\u3001\u8054\u5408\u5f00\u53d1\u53ca\u591a\u5143\u5316\u7684\u5408\u4f5c\u6a21\u5f0f\u5feb\u901f\u62d3\u5c55\u521b\u65b0\u836f\u7814\u53d1\u7ba1\u7ebf\u3002<\/p>\n<p>\u548c\u94c2\u81ea\u6709\u7684\u6297\u4f53\u6280\u672f\u5e73\u53f0Harbour 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