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type=\"disc\">\n<li>\u533b\u7597\u793e\u533a\u53c2\u4e0e\uff0c\u652f\u6301\u4ea7\u54c1\u6210\u529f\u4e0a\u5e02<\/li>\n<\/ul>\n<p>\u6211\u4eec\u79ef\u6781\u4e0e\u533b\u7597\u754c\u5229\u76ca\u76f8\u5173\u8005\u5408\u4f5c\u4ee5\u6269\u5927\u6211\u4eec\u7684\u5e02\u573a\u8f90\u5c04\u8303\u56f4\uff0c\u76ee\u524d\u5df2\u8986\u76d6130\u591a\u4e2a\u57ce\u5e02\u7684 400 \u591a\u5bb6\u533b\u9662\uff0c\u5e76\u52a0\u6df1\u6211\u4eec\u4e0e\u533b\u7597\u670d\u52a1\u63d0\u4f9b\u65b9\u3001\u836f\u623f\u3001\u60a3\u8005\u7fa4\u4f53\u53ca\u4fdd\u9669\u516c\u53f8\u7684\u5408\u4f5c\u3002\u9500\u552e\u56e2\u961f\u6b63\u4e3a\u6211\u4eec\u7684\u836f\u7269\u5728\u4e2d\u56fd\u5efa\u7acb\u5168\u9762\u5e02\u573a\u8986\u76d6\uff0c\u5df2\u8986\u76d6\u7684\u533b\u9662\u5360\u7cbe\u51c6\u6cbb\u7597\u836f\u7269\u76f8\u5173\u5e02\u573a\u7ea670-80%\u3002\u6b64\u5916\uff0c\u6211\u4eec\u7684\u7cbe\u51c6\u6cbb\u7597\u836f\u7269\u88ab\u7eb3\u516520\u9879\u4e3b\u8981\u5546\u4e1a\u4fdd\u9669\u53ca\u653f\u5e9c\u4fdd\u9669\u8ba1\u5212\u3002\u901a\u8fc7\u4e0a\u8ff0\u52aa\u529b\uff0c\u6211\u4eec\u5df2\u6784\u5efa\u8d77\u5f3a\u5927\u7684\u7f51\u7edc\u4ee5\u652f\u6301\u9996\u6279\u4e24\u6b3e\u4ea7\u54c1\u7684\u4e0a\u5e02\uff0c\u5e76\u4e3a\u672a\u6765\u7684\u4ea7\u54c1\u4e0a\u5e02\u94fa\u5e73\u9053\u8def\u3002<\/p>\n<p>\u6211\u4eec\u7684\u4e24\u6b3e\u7cbe\u51c6\u6cbb\u7597\u836f\u7269\uff0c\u81ea\u4e0a\u5e02\u9996\u65e5\u5df2\u8986\u76d6\u5e7f\u5927\u60a3\u8005\u30022021\u5e745\u6708\u548c2021\u5e746\u6708\uff0c\u6211\u4eec\u5206\u522b\u5728\u4e2d\u56fd\u5927\u9646\u53ca\u53f0\u6e7e\u5730\u533a\u6210\u529f\u4e0a\u5e02\u4e86\u6cf0\u5409\u534e<sup>&reg;<\/sup>\u53ca\u6cf0\u6642\u7dad<sup>&reg;<\/sup>\uff0c2021\u5e74\u4e0a\u534a\u5e74\u5b9e\u73b0\u51c0\u9500\u552e\u989d\u4eba\u6c11\u5e013,360\u4e07\u5143\u30022021\u5e746\u6708\uff0c\u6211\u4eec\u5728\u4e2d\u56fd\u5927\u9646\u6210\u529f\u4e0a\u5e02\u666e\u5409\u534e<sup>&reg;<\/sup>\uff0c2021\u5e74\u4e0a\u534a\u5e74\u5b9e\u73b0\u51c0\u9500\u552e\u989d\u4eba\u6c11\u5e014,580 \u4e07\u5143\u3002<\/p>\n<ul type=\"disc\">\n<li>\u6218\u7565\u5408\u4f5c\u534f\u8bae\uff0c\u652f\u6301\u4ea7\u54c1\u5206\u9500<\/li>\n<\/ul>\n<p>\u6211\u4eec\u5df2\u4e0e\u56fd\u836f\u63a7\u80a1\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff08\u56fd\u836f\u63a7\u80a1\uff09\u7b7e\u7f72\u6218\u7565\u5408\u4f5c\u534f\u8bae\u3002\u901a\u8fc7\u6b64\u534f\u8bae\uff0c\u6211\u4eec\u80fd\u591f\u6269\u5927\u666e\u5409\u534e<sup>&reg;<\/sup>\u53ca\u6cf0\u5409\u534e<sup>&reg;<\/sup>\u5728\u4e2d\u56fd\u5927\u9646\u533b\u9662\u53ca\u836f\u623f\u7684\u5206\u9500\u8303\u56f4\u3002\u901a\u8fc7\u4e0e\u4e2d\u56fd\uff08\u4e0a\u6d77\uff09\u81ea\u7531\u8d38\u6613\u8bd5\u9a8c\u533a\u4e34\u6e2f\u65b0\u7247\u533a\uff08\u4e34\u6e2f\uff09\u7684\u5408\u4f5c\uff0c\u6211\u4eec\u5728\u56db\u5929\u5185\u5b8c\u6210\u901a\u5173\u53ca\u53e3\u5cb8\u68c0\u67e5\u7a0b\u5e8f\uff0c\u6bd4\u9884\u671f\u65f6\u95f4\u5927\u5e45\u63d0\u524d\uff0c\u8fdc\u8d85\u884c\u4e1a\u5e73\u5747\u901f\u5ea6\uff0c\u52a0\u5feb\u5e02\u573a\u51c6\u5165\u8fdb\u7a0b\u3002<\/p>\n<p>\u6211\u4eec\u4e0e\u4e2d\u56fd\u5927\u9646\u4e09\u5927\u7efc\u5408\u533b\u7597\u670d\u52a1\u5e73\u53f0 &#8212; \u4e0a\u6d77\u9541\u4fe1\u5065\u5eb7\u79d1\u6280\u6709\u9650\u516c\u53f8\u3001\u5317\u4eac\u5706\u5fc3\u79d1\u6280\u96c6\u56e2\u6709\u9650\u516c\u53f8\u53ca\u601d\u6d3e\u5065\u5eb7\u79d1\u6280\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u534f\u8bae\uff0c\u53d1\u6325\u5404\u65b9\u7684\u7ade\u4e89\u4f18\u52bf\u53ca\u5229\u7528\u521b\u65b0\u7684\u533b\u7597\u652f\u4ed8\u8ba1\u5212\uff0c\u6700\u5927\u7a0b\u5ea6\u5730\u4fc3\u8fdb\u666e\u5409\u534e<sup>&reg;<\/sup>\u53ca\u6cf0\u5409\u534e<sup>&reg;<\/sup>\u7684\u5206\u9500\u53ca\u63d0\u9ad8\u60a3\u8005\u7684\u53ef\u652f\u4ed8\u80fd\u529b\u3002<\/p>\n<ul type=\"disc\">\n<li>\u5546\u4e1a\u8fd0\u8425\uff0c\u6269\u5927\u5e02\u573a\u6f5c\u529b\u53ca\u540e\u671f\u7ba1\u7ebf\u8d44\u4ea7\u7684\u4e0a\u5e02\u51c6\u5907<\/li>\n<\/ul>\n<p>\u6211\u4eec\u4e0e\u5408\u4f5c\u4f19\u4f34\u8f89\u745e\u53caEQRx\u6b63\u5728\u5c55\u5f00\u5bc6\u5207\u5408\u4f5c\uff0c\u8ba1\u5212\u8fdb\u884c\u8212\u683c\u5229\u5355\u6297\u5728\u4e2d\u56fd\u5927\u9646\u7684\u5546\u4e1a\u5316\u53ca\u5728\u5168\u7403\uff08\u5927\u4e2d\u534e\u533a\u4ee5\u5916\uff09\u7684\u4e0a\u5e02\u3002\u6211\u4eec\u4e0e\u8f89\u745e\u7684\u5408\u4f5c\u4ee4\u6211\u4eec\u6709\u671b\u4e8e\u4eca\u5e74\u5728\u4e2d\u56fd\u5927\u9646\u83b7\u5f97\u8212\u683c\u5229\u5355\u6297\u6cbb\u7597IV\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684NDA\u6279\u51c6\u3002\u8fd9\u5c06\u5b9e\u8d28\u6027\u5730\u63a8\u8fdb\u8fd9\u6b3e\u836f\u7269\u7684\u5168\u9762\u5546\u4e1a\u4e0a\u5e02\u3002\u6211\u4eec\u4e0e EQRx \u7684\u5408\u4f5c\u4e3a\u8212\u683c\u5229\u5355\u6297\u5728\u7f8e\u56fd\u3001\u82f1\u56fd\u53ca\u6b27\u76df\u7b49\u5e02\u573a\u7684\u5e7f\u6cdb\u5206\u9500\u6253\u4e0b\u575a\u5b9e\u57fa\u7840\uff0cPD-(L)1\u5728\u8fd9\u4e9b\u5e02\u573a\u7528\u4e8e\u6cbb\u7597NSCLC\u3001\u80c3\u764c\u53ca\u98df\u7ba1\u764c\u7684\u9500\u552e\u989d\u9884\u6d4b\u57282026\u5e74\u7ea6\u4e3a300 \u4ebf\u7f8e\u5143\u3002<\/p>\n<p>\u6211\u4eec\u5df2\u5b9e\u65bd\u591a\u9879\u63aa\u65bd\u4e3a\u6269\u5927\u666e\u5409\u534e<sup>&reg;<\/sup>\u53ca\u6cf0\u5409\u534e<sup>&reg;<\/sup>\u7684\u9002\u5e94\u75c7\u505a\u51c6\u5907\uff0c\u4ee5\u4ea7\u751f\u66f4\u5927\u7684\u957f\u671f\u9500\u552e\u7684\u589e\u957f\u6f5c\u529b\u3002\u5bf9\u4e8e\u666e\u5409\u534e<sup>&reg;<\/sup>\uff0c\u6211\u4eec\u5df2\u5728\u4e2d\u56fd\u5927\u9646\u9012\u4ea4\u6cbb\u7597&nbsp;RET\u7a81\u53d8\u7532\u72b6\u817a\u9ad3\u6837\u764c\uff08MTC\uff09\u53caRET\u878d\u5408\u9633\u6027\u7532\u72b6\u817a\u764c\u7684NDA\uff0c\u5e76\u5df2\u88ab\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u3002\u6211\u4eec\u9884\u671f\u5c06\u4e8e2021\u5e74\u4e0b\u534a\u5e74\u5728\u4e2d\u56fd\u5927\u9646\u9012\u4ea4\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597 RET\u878d\u5408\u9633\u6027NSCLC\u7684NDA\u3002\u6b64\u5916\uff0c\u6211\u4eec\u9884\u8ba1\u5c06\u4e8e2021\u5e74\u4e0b\u534a\u5e74\u5728\u4e2d\u56fd\u9999\u6e2f\u53ca\u53f0\u6e7e\u5730\u533a\u9012\u4ea4\u666e\u5409\u534e<sup>&reg;<\/sup>\u6cbb\u7597RET\u878d\u5408\u9633\u6027NSCLC\u7684NDA\u3002\u5bf9\u4e8e\u6cf0\u5409\u534e<sup>&reg;<\/sup>\uff0c\u6211\u4eec\u5df2\u5728\u9999\u6e2f\u9012\u4ea4\u4e86\u6cbb\u7597PDGFRA D842V\u7a81\u53d8\u80c3\u80a0\u9053\u95f4\u8d28\u7624\uff08GIST\uff09\u7684NDA\u3002\u53e6\u5916\uff0c\u7ee7\u7f8e\u56fdFDA\u6279\u51c6\u6cbb\u7597\u665a\u671f\u7cfb\u7edf\u6027\u80a5\u5927\u7ec6\u80de\u589e\u591a\u75c7\uff08SM\uff09\u6210\u4eba\u60a3\u8005\u4e4b\u540e\uff0c\u6211\u4eec\u6b63\u63a2\u5bfb\u5728\u4e2d\u56fd\u5927\u9646\u52a0\u5feb\u6ce8\u518c\u4e0a\u5e02\u53ef\u80fd\u7684\u9014\u5f84\u3002<\/p>\n<p>\u6211\u4eec\u5df2\u7ecf\u63a8\u8fdb\u827e\u4f0f\u5c3c\u5e03\uff08IDH1\u6291\u5236\u5242\uff09\u7684\u4e0a\u5e02\u7b79\u5907\u5de5\u4f5c\uff0c\u5e76\u9884\u671f\u5c06\u4e8e2021\u5e74\u7b2c\u56db\u5b63\u5ea6\u62162022\u5e74\u7b2c\u4e00\u5b63\u5ea6\u83b7\u5f97\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u6027\u6025\u6027\u9ad3\u6027\u767d\u8840\u75c5\uff08R\/R AML\uff09\u60a3\u8005\u7684NDA\u6279\u51c6\u3002<\/p>\n<p>II.&nbsp;&nbsp; \u5927\u91cf\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6210\u529f\u652f\u6301\u6210\u719f\u7ba1\u7ebf\u7684\u53d1\u5c55<\/p>\n<p>2021\u5e74\u4e0a\u534a\u5e74\uff0c\u6211\u4eec\u5728\u591a\u4e2a\u80bf\u7624\u6cbb\u7597\u9886\u57df\u53ca\u9002\u5e94\u75c7\u5efa\u7acb\u6210\u719f\u7684\u540e\u671f FIC\u7ba1\u7ebf\u8d44\u4ea7\u65b9\u9762\u53d6\u5f97\u91cd\u5927\u8fdb\u5c55\uff0c\u603b\u4f53\u6269\u5927\u6211\u4eec\u7684\u6f5c\u5728\u76ee\u6807\u5e02\u573a\u3002\u6211\u4eec\u53d6\u5f97\u4e09\u9879NDA \u6279\u51c6\uff0c\u4ee5\u652f\u6301\u666e\u62c9\u66ff\u5c3c\u53ca\u963f\u4f10\u66ff\u5c3c\u7684\u4e0a\u5e02\u3002\u6211\u4eec\u5df2\u9012\u4ea4\u56db\u9879NDA \u7533\u8bf7\uff0c\u5305\u62ec\u7b2c\u4e09\u4e2a\u4ea7\u54c1\u827e\u4f0f\u5c3c\u5e03\uff0c\u4ee5\u53ca\u666e\u62c9\u66ff\u5c3c\u3001\u963f\u4f10\u66ff\u5c3c\u53ca\u8212\u683c\u5229\u5355\u6297\u7684\u6269\u5c55\u9002\u5e94\u75c7\u548c\u5730\u533a\u8986\u76d6\u3002\u4e0e\u5f80\u5e74\u76f8\u6bd4\uff0c\u6211\u4eec\u4e5f\u5927\u5e45\u589e\u52a0\u8ba1\u5212\u7684\u6570\u636e\u7ed3\u679c\u53d1\u5e03\u53ca\u62a5\u544a\u7684\u6570\u91cf\u3002<\/p>\n<p>\u5c24\u4e3a\u91cd\u8981\u7684\u662f\uff0c\u6211\u4eec\u5ba3\u5e03\u4e86\u6709\u5173\u8212\u683c\u5229\u5355\u6297\u7684\u591a\u9879\u79ef\u6781\u8fdb\u5c55\uff0c\u8bc1\u5b9e\u5176\u7528\u4e8e\u6cbb\u7597&nbsp;III\u671f\u53caIV\u671f NSCLC \u7684\u5e7f\u6cdb\u9002\u7528\u6027\u53ca\u5b89\u5168\u6027\uff0c\u5305\u62ec\u5728\u201c\u5168\u4eba\u7fa4\u201d\u7684\u5e7f\u6cdb\u9002\u7528\u6027\u53ca\u5b89\u5168\u6027\uff0c\u8fd9\u53ef\u4ee5\u4e3a\u5176\u5efa\u7acb\u72ec\u6709\u4e14\u6f5c\u5728\u6301\u4e45\u7684\u5e02\u573a\u5b9a\u4f4d\u3002<\/p>\n<p>\u8be6\u60c5\u5982\u4e0b\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u8212\u683c\u5229\u5355\u6297\uff08CS1001\uff0cPD-L1\u6297\u4f53\uff09<\/li>\n<\/ul>\n<p>2021\u5e745\u6708\uff0c\u8212\u683c\u5229\u5355\u6297\u5355\u836f\u4f5c\u4e3a\u5de9\u56fa\u6cbb\u7597\u5728\u540c\u6b65\u6216\u5e8f\u8d2f\u653e\u5316\u7597\u540eIII\u671fNSCLC\u60a3\u8005\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u8fbe\u5230\u5176\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u3002\u8be5\u9879\u8bd5\u9a8c\u7684\u521b\u65b0\u8bbe\u8ba1\u66f4\u52a0\u7b26\u5408\u771f\u5b9e\u4e16\u754c\u4e34\u5e8a\u5b9e\u8df5\uff0c\u5e76\u5c55\u73b0\u4e86\u8212\u683c\u5229\u5355\u6297\u7684\u72ec\u7279\u80fd\u529b\uff0c\u80fd\u5728PD-(L)1\u6cbb\u7597\u4e2d\u8986\u76d6\u66f4\u5e7f\u6cdb\u7684\u60a3\u8005\u7fa4\u4f53\u3002\u6211\u4eec\u5df2\u4e8e2021 \u5e748\u6708\u5411\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u63d0\u4ea4\u6709\u5173\u8be5\u9002\u5e94\u75c7\u7684NDA\u3002<\/p>\n<p>IV\u671f\u9cde\u72b6\u53ca\u975e\u9cde\u72b6NSCLC\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684PFS\u6700\u7ec8\u5206\u6790\u8868\u660e\uff0c\u8212\u683c\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u4f5c\u4e3a\u4e00\u7ebf\u6cbb\u7597\uff0c\u8fdb\u4e00\u6b65\u663e\u8457\u5ef6\u957fPFS\uff0c\u5e76\u63d0\u9ad8\u603b\u751f\u5b58\u671f\u3002NMPA\u4e8e2020\u5e7411\u6708\u53d7\u7406\u8be5\u9002\u5e94\u75c7\u7684NDA\uff0c\u6211\u4eec\u9884\u671f\u5176\u5c06\u57282021\u5e74\u5e74\u5e95\u83b7\u6279\u3002\u6b64\u5916\uff0c\u6211\u4eec\u6b63\u4e0eEQRx\u5c55\u5f00\u5bc6\u5207\u5408\u4f5c\uff0c\u4e0e\u7f8e\u56fd\u7b49\u591a\u4e2a\u56fd\u5bb6\u7684\u76d1\u7ba1\u90e8\u95e8\u5c31III\u671f\u53caIV\u671fNSCLC\u7684\u4e24\u4e2a\u9002\u5e94\u75c7\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u5c55\u5f00\u6c9f\u901a\u3002<\/p>\n<ul type=\"disc\">\n<li>\u666e\u62c9\u66ff\u5c3c\uff08CS3009\uff0cRET\u6291\u5236\u5242\uff09<\/li>\n<\/ul>\n<p>2021\u5e743\u670824\u65e5\uff0cNMPA\u5df2\u6279\u51c6\u5176\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u542b\u94c2\u5316\u7597\u7684RET\u878d\u5408\u9633\u6027NSCLC\u60a3\u8005\u7684NDA\u3002<\/p>\n<p>2021\u5e744\u6708\uff0cNMPA\u53d7\u7406\u5176\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u6216\u8f6c\u79fb\u6027RET\u7a81\u53d8MTC\u53caRET\u878d\u5408\u9633\u6027\u7532\u72b6\u817a\u764c\u60a3\u8005\u7684NDA\uff0c\u5e76\u6388\u4e88\u5176\u4f18\u5148\u5ba1\u8bc4\u8d44\u683c\u3002<\/p>\n<ul type=\"disc\">\n<li>\u963f\u4f10\u66ff\u5c3c\uff08CS3007\uff0cKIT\/PDGFRA\u6291\u5236\u5242\uff09<\/li>\n<\/ul>\n<p>2021\u5e743\u670831\u65e5\uff0cNMPA\u6279\u51c6\u5176\u7528\u4e8e\u6cbb\u7597\u643a\u5e26PDGFRA\u5916\u663e\u5b5018\u7a81\u53d8\uff08\u5305\u62ecPDGFRA D842V\u7a81\u53d8\uff09\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027GIST\u6210\u4eba\u60a3\u8005\u7684NDA\u3002<\/p>\n<p>2021\u5e744\u670829\u65e5\uff0c\u901a\u8fc7\u52a0\u901f\u6279\u51c6\u9014\u5f84\uff0c\u53f0\u6e7e\u98df\u54c1\u836f\u7269\u7ba1\u7406\u7f72\u6279\u51c6\u5176\u7528\u4e8e\u6cbb\u7597PDGFRA D842V\u7a81\u53d8\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027GIST\u6210\u4eba\u60a3\u8005\u7684NDA\u3002<\/p>\n<p>2021\u5e745\u6708\uff0c\u9999\u6e2f\u536b\u751f\u7f72\u53d7\u7406\u5176\u7528\u4e8e\u6cbb\u7597\u643a\u5e26PDGFRA D842V\u7a81\u53d8\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027GIST\u6210\u4eba\u60a3\u8005\u7684NDA\u3002\u6211\u4eec\u9884\u671f\u5c06\u4e8e2022\u5e74\u4e0b\u534a\u5e74\u6536\u5230\u51b3\u5b9a\u3002<\/p>\n<ul type=\"disc\">\n<li>\u827e\u4f0f\u5c3c\u5e03(CS3010\uff0cIDH1\u6291\u5236\u5242\uff09<\/li>\n<\/ul>\n<p>\u827e\u4f0f\u5c3c\u5e03\u7528\u4e8e\u6cbb\u7597\u643a\u5e26\u6613\u611f\u5f02\u67e0\u6aac\u9178\u8131\u6c22\u9176-1\uff08IDH1\uff09\u7a81\u53d8\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u6025\u6027\u9ad3\u6027\u767d\u8840\u75c5\uff08R\/R AML\uff09\u60a3\u8005\u7684\u6ce8\u518c\u6027\u8bd5\u9a8c\u8fbe\u5230\u9884\u5148\u8bbe\u5b9a\u7684\u7814\u7a76\u7ec8\u70b9\u3002\u827e\u4f0f\u5c3c\u5e03\u662f\u4e2d\u56fd\u9996\u4e2a\u5bf9R\/R AML\u60a3\u8005\u5c55\u73b0\u51fa\u7597\u6548\u53ca\u6301\u7eed\u7f13\u89e3\u7684IDH1\u6291\u5236\u5242\u3002<\/p>\n<p>2021\u5e748\u6708\uff0cNMPA\u53d7\u7406\u5176\u7528\u4e8e\u6cbb\u7597\u643a\u5e26IDH1\u6613\u611f\u7a81\u53d8\u7684R\/R AML\u6210\u4eba\u60a3\u8005\u7684NDA\uff0c\u5e76\u6388\u4e88\u5176\u4f18\u5148\u5ba1\u8bc4\u8d44\u683c\u3002\u6211\u4eec\u9884\u671f\u5c06\u4e8e2021\u5e74\u5e95\u6216\u80052022\u5e74\u7b2c\u4e00\u5b63\u5ea6\u83b7\u5f97NDA\u6279\u51c6\u3002<\/p>\n<p>2021\u5e748\u6708\uff0c\u6211\u4eec\u7684\u5408\u4f5c\u4f19\u4f34\u65bd\u7ef4\u96c5\u53d1\u5e03\u6709\u5173\u827e\u4f0f\u5c3c\u5e03\u4e0e\u963f\u624e\u80de\u82f7\u8054\u5408\u6cbb\u7597\u5148\u524d\u672a\u7ecf\u6cbb\u7597\u7684IDH1 \u7a81\u53d8\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u60a3\u8005\u7684\u5168\u7403III\u671f\u7814\u7a76\u7684\u9633\u6027\u6570\u636e\u3002\u7531\u4e8e\u6781\u5176\u4f18\u5f02\u7684\u7597\u6548\u6570\u636e\uff0c\u8be5\u9879\u7814\u7a76\u8fd1\u671f\u5df2\u505c\u6b62\u8fdb\u4e00\u6b65\u5165\u7ec4\u3002\u6211\u4eec\u9884\u671f\u5c06\u4e8e2022\u5e74\u5411NMPA\u9012\u4ea4\u8be5\u9002\u5e94\u75c7\u7684 NDA\u3002<\/p>\n<p>III.&nbsp;&nbsp; \u6218\u7565\u5173\u7cfb\u63a8\u8fdb\u540e\u671f\u7ba1\u7ebf\u4ea7\u54c1\u7684\u53d1\u5c55\u524d\u666f\u5e76\u5de9\u56fa\u7ba1\u7ebf\u5f00\u53d1<\/p>\n<p>\u6211\u4eec\u7ee7\u7eed\u6df1\u5316\u53d1\u5c55\u4e0e\u5168\u7403\u4e3b\u8981\u6218\u7565\u5408\u4f5c\u4f19\u4f34\u8f89\u745e\u53caEQRx\u7684\u5173\u7cfb\u3002<\/p>\n<p>\u6211\u4eec\u6b63\u4e0e\u8f89\u745e\u8fdb\u884c\u5408\u4f5c\uff0c\u8ba1\u5212\u8fdb\u884c\u8212\u683c\u5229\u5355\u6297\u7528\u4e8e\u6cbb\u7597IV\u671fNSCLC\u5728\u4e2d\u56fd\u5927\u9646\u7684\u5546\u4e1a\u5316\u3002\u6211\u4eec\u4e0e\u8f89\u745e\u5408\u4f5c\u4e0e\u76d1\u7ba1\u673a\u6784\u8fdb\u884c\u6d3d\u8c08\uff0c\u5e76\u5f00\u5c55\u7d27\u5bc6\u534f\u4f5c\u4ee5\u5efa\u7acb\u4e0e\u533b\u7597\u754c\u5176\u4ed6\u91cd\u8981\u5229\u76ca\u76f8\u5173\u8005\u7684\u8054\u7cfb\uff0c\u63d0\u5347\u4ed6\u4eec\u5bf9\u4ea7\u54c1\u7684\u8ba4\u77e5\u3002\u6211\u4eec\u7684\u4e0d\u61c8\u52aa\u529b\u65e8\u5728\u4e3a\u8212\u683c\u5229\u5355\u6297\u5546\u4e1a\u5316\u4e0a\u5e02\u540e\u53ef\u5e7f\u6cdb\u5feb\u901f\u5730\u5360\u9886\u5e02\u573a\u4ee5\u53ca\u63d0\u9ad8\u9500\u552e\u5960\u5b9a\u57fa\u7840\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u6211\u4eec\u5728\u4eca\u5e74\u4e0a\u534a\u5e74\u8fdb\u4e00\u6b65\u6df1\u5316\u4e86\u4e0e\u8f89\u745e\u7684\u5408\u4f5c\uff0c\u8fbe\u6210\u534f\u8bae\u5728\u5927\u4e2d\u534e\u533a\u8054\u5408\u5f00\u53d1\u5176\u540e\u671f\u80bf\u7624\u8d44\u4ea7\u52b3\u62c9\u66ff\u5c3c\u7528\u4e8e\u4e8c\u7ebf\u6cbb\u7597&nbsp;c-ros oncogene 1 ( ROS1) \u9633\u6027NSCLC\u3002\u8fd9\u662f\u7ee7\u6211\u4eec\u53bb\u5e74\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u540e\uff0c\u53cc\u65b9\u5408\u4f5c\u7684\u8fdb\u4e00\u6b65\u5ef6\u4f38\uff0c\u662f\u4e34\u5e8a\u5f00\u53d1\u53ca\u53cc\u65b9\u5173\u7cfb\u7684\u91cd\u8981\u8fdb\u5c55\u3002\u52b3\u62c9\u66ff\u5c3c\u7684\u5f00\u53d1\u8ba1\u5212\u662f\u8bc4\u4f30\u8be5\u836f\u7269\u662f\u5426\u53ef\u5bf9\u514b\u5511\u66ff\u5c3c\u6cbb\u7597\u540e\u590d\u53d1\u7684ROS1 \u9633\u6027\u665a\u671fNSCLC\u63d0\u4f9b\u53d7\u76ca\uff0c\u8fd9\u5c06\u4e3a\u6211\u4eec\u7684\u80ba\u764c\u6cbb\u7597\u65b9\u6848\u518d\u6dfb\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u8fd9\u9879\u8ba1\u5212\u5c06\u8fdb\u4e00\u6b65\u5de9\u56fa\u6211\u4eec\u4e0e\u5168\u7403\u751f\u7269\u5236\u836f\u9886\u5bfc\u8005\u4e4b\u95f4\u7684\u5408\u4f5c\u5173\u7cfb\u3002<\/p>\n<p>\u6211\u4eec\u548cEQRx\u5171\u540c\u4e0e\u7f8e\u56fd\u3001\u82f1\u56fd\u53ca\u6b27\u76df\u7b49\u5168\u7403\u4e3b\u8981\u5e02\u573a\u7684\u5229\u76ca\u76f8\u5173\u8005\u5c31\u8212\u683c\u5229\u5355\u6297\u6cbb\u7597NSCLC \u9002\u5e94\u75c7\u7684\u6ce8\u518c\u8fdb\u884c\u6d3d\u8c08\u3002\u6211\u4eec\u8fd8\u4e0eEQRx\u5408\u4f5c\u63a2\u7a76\u6269\u5927\u8be5\u836f\u7269\u9002\u5e94\u75c7\u8303\u56f4\u7684\u53ef\u884c\u6027\uff08\u5305\u62ec\u80c3\u764c\u53ca\u98df\u7ba1\u764c\uff09\u3002\u6b64\u5916\uff0c\u6211\u4eec\u6b63\u4e0eEQRx\u534f\u529b\u5408\u4f5c\uff0c\u5728\u7f8e\u56fd\u53ca\u4e3b\u8981\u6b27\u6d32\u5e02\u573a\u6269\u5927CS1003\u6cbb\u7597\u809d\u7ec6\u80de\u764cIII\u671f\u7814\u7a76\u3002<\/p>\n<p>IV.&nbsp;&nbsp; \u6253\u9020\u7ba1\u7ebf2.0\u5145\u5206\u53d1\u6325\u4e0b\u4e00\u4ee3\u5019\u9009\u836f\u7269\u6f5c\u529b<\/p>\n<p>\u6211\u4eec\u901a\u8fc7\u7814\u53d1\u56e2\u961f\u91cd\u7ec4\uff0c\u63d0\u5347\u7814\u53d1\u80fd\u529b\uff0c\u5168\u529b\u63a8\u8fdbFIC\u4e0eBIC\u4ea7\u54c1\u7684\u5f00\u53d1\u3002\u6211\u4eec\u5c06\u901a\u8fc7\u5728\u7814\u53d1\u65b9\u9762\u7684\u4e0d\u61c8\u52aa\u529b\uff0c\u589e\u5f3a\u5185\u6e90\u521b\u65b0\u80fd\u529b\uff0c\u6253\u9020\u5177\u5907\u5168\u7403\u6743\u76ca\u7684\u5dee\u5f02\u5316\u521b\u65b0\u836f\u7269\u7ba1\u7ebf\uff0c\u5b9e\u73b0\u6bcf\u5e74\u9012\u4ea4\u4e00\u81f3\u4e24\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\uff08IND\uff09\u3002<\/p>\n<p>\u6211\u4eec\u7ba1\u7ebf2.0\u7684\u8fd1\u671f\u5e03\u5c40\u91cd\u70b9\u4e3a\u4e24\u79cd\u65b0\u5174\u6cbb\u7597\u6a21\u5f0f\uff1a\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09\u53ca\u591a\u7279\u5f02\u6027\u6297\u4f53\u30022021\u4e0a\u534a\u5e74\uff0c\u6211\u4eec\u5728\u63a8\u8fdb\u6b64\u7c7b\u91cd\u70b9\u4ea7\u54c1\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\u4e0a\u5df2\u53d6\u5f97\u91cd\u5927\u8fdb\u5c55\uff1a<\/p>\n<ul type=\"disc\">\n<li>CS2006\uff08NM21-1480\u3001PD-L1&times;4-1BB&times;HSA\u4e09\u7279\u5f02\u6027\u6297\u4f53\uff09\uff1a\u5242\u91cf\u9012\u589e\u6b63\u4e8e\u7f8e\u56fd\u53ca\u4e2d\u56fd\u53f0\u6e7e\u5730\u533a\u5f00\u5c55\u3002\u6211\u4eec\u5df2\u5728\u7f8e\u56fd\u5b8c\u6210\u7b2c4\u4e2a\u5242\u91cf\u6c34\u5e73\u7684\u60a3\u8005\u62db\u52df\uff0c\u7b2c5\u4e2a\u5242\u91cf\u6c34\u5e73\u7684\u60a3\u8005\u62db\u52df\u6b63\u5728\u8fdb\u884c\u3002\u6b64\u5916\uff0c\u6211\u4eec\u5df2\u5411NMPA\u9012\u4ea4 IND\u7533\u8bf7\uff0c\u5e76\u4e8e2021\u5e747\u6708\u83b7\u53d7\u7406\u3002 <\/li>\n<li>CS5001\uff08LCB71\u3001ROR1 ADC\uff09\uff1a\u7528\u4e8e\u5168\u7403IND\u51c6\u5907\u7814\u7a76\u6b63\u5728\u8fdb\u884c\uff0c\u9884\u671f\u5c06\u4e8e2021\u5e74\u5e74\u5e95\u524d\u5b8c\u6210\u5728\u7f8e\u56fd\u2571\u6fb3\u6d32\u9012\u4ea4IND\/CTA\u3002<\/li>\n<\/ul>\n<p>\u9664CS2006\u53caCS5001\u5916\uff0c\u6211\u4eec\u4ea6\u5728\u540c\u6b65\u5f00\u53d1\u62e5\u6709\u5168\u7403\u5546\u4e1a\u6743\u5229\u7684\u5176\u4ed6FIC\/BIC\/FW\u4ea7\u54c1\uff0c\u5305\u62ec\u4e24\u4e2a\u591a\u7279\u5f02\u6027\u6297\u4f53\u53ca\u4e00\u4e2aADC\u3002<\/p>\n<p>V.&nbsp;&nbsp; \u62d3\u5c55\u8d44\u672c\u5e02\u573a\u673a\u9047<\/p>\n<p>\u9274\u4e8e\u6211\u4eec\u7684\u80a1\u7968\u5728\u622a\u81f32021\u5e746\u6708\u6b62\u768412\u4e2a\u6708\u7684\u5f3a\u52b2\u8868\u73b0\uff0c\u6211\u4eec\u7684\u80a1\u7968\u5df2\u88ab\u7eb3\u5165\u6052\u751f\u7efc\u5408\u6307\u6570\uff0c\u5e76\u9884\u671f\u5373\u5c06\u7eb3\u5165\u6e2f\u80a1\u901a\u3002\u8fd9\u4e00\u8fdb\u5c55\u7684\u91cd\u8981\u610f\u4e49\u5728\u4e8e\u5176\u53ef\u4fc3\u8fdb\u6211\u4eec\u80a1\u7968\u7684\u4ea4\u6613\u91cf\u589e\u52a0\uff0c\u63a8\u52a8\u66f4\u6709\u6548\u7684\u4ef7\u683c\u53d1\u73b0\u53ca\u4e3a\u6295\u8d44\u8005\u63d0\u4f9b\u989d\u5916\u7684\u6d41\u901a\u6027\u3002<\/p>\n<p><b>\u8d22\u52a1\u6458\u8981<\/b><\/p>\n<ul type=\"disc\">\n<li>\u622a\u81f32021\u5e746\u670830\u65e5\u6b62\u76846\u4e2a\u6708\uff0c\u516c\u53f8\u6536\u5165\u4e3a\u4eba\u6c11\u5e017,940\u4e07\u5143\uff0c\u4e3b\u8981\u7531\u4e8e\u9500\u552e\u672c\u516c\u53f8\u836f\u54c1\uff08\u963f\u4f10\u66ff\u5c3c\u53ca\u666e\u62c9\u66ff\u5c3c\uff09\u3002\u5176\u4e2d\uff0c\u963f\u4f10\u66ff\u5c3c\u53ca\u666e\u62c9\u66ff\u5c3c\u7684\u6536\u5165\u5206\u522b\u8fbe\u5230\u4eba\u6c11\u5e013,360\u4e07\u5143\u53ca\u4eba\u6c11\u5e014,580\u4e07\u5143\u3002 <\/li>\n<li>\u6263\u9664\u4ee5\u80a1\u4efd\u4e3a\u57fa\u7840\u7684\u4ed8\u6b3e\u5f00\u652f\u540e\uff0c\u7814\u53d1\u5f00\u652f\u4e3a\u4eba\u6c11\u5e014.448\u4ebf\u5143\uff0c\u884c\u653f\u3001\u9500\u552e\u53ca\u8425\u9500\u5f00\u652f\u4e3a2.143\u4ebf\u5143\uff0c\u671f\u5185\u4e8f\u635f\u4e3a6.325\u4ebf\u5143\u3002 <\/li>\n<li>\u622a\u81f32021\u5e746\u670830\u65e5\uff0c\u6211\u4eec\u7684\u5b9a\u671f\u5b58\u6b3e\u4ee5\u53ca\u73b0\u91d1\u53ca\u73b0\u91d1\u7b49\u4ef7\u7269\u4e3a\u4eba\u6c11\u5e0124.472\u4ebf\u5143\u3002<\/li>\n<\/ul>\n<p><b>2021\u5e74\u4e2d\u671f\u4e1a\u7ee9\u53d1\u5e03\u4f1a\u4fe1\u606f<\/b><\/p>\n<p>\u672c\u516c\u53f8\u5c06\u4e8e2021\u5e748\u670827\u65e5\u4e0a\u534810\u65f6\uff08\u9999\u6e2f\u65f6\u95f4\uff09\u8fdb\u884c2021\u5e74\u4e2d\u671f\u4e1a\u7ee9\u53d1\u5e03\u4f1a\u7684\u7f51\u7edc\u76f4\u64ad\u3002\u53c2\u4f1a\u8bbf\u95ee\u4fe1\u606f\u5982\u4e0b\uff1a<\/p>\n<p><b><a target=\"_blank\" href=\"https:\/\/goldmansachs.zoom.us\/webinar\/register\/WN_mn1nvi0iSGWRde3dRGFNPw\" rel=\"nofollow noopener\">https:\/\/goldmansachs.zoom.us\/webinar\/register\/WN_mn1nvi0iSGWRde3dRGFNPw<\/a><\/b><\/p>\n<p>\u4f1a\u8baeID\uff1a939 2219 3743<br \/>\u4f1a\u8bae\u5bc6\u7801: 778867<\/p>\n<p>\u76f8\u5173\u94fe\u63a5 :<\/p>\n<p>http:\/\/www.cstonepharma.com<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e2d\u56fd\u82cf\u5dde2021\u5e748\u670826\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u57fa\u77f3\u836f\u4e1a\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a2616\uff09\uff0c\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u7814\u7a76\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u521b\u65b0\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u53ca\u7cbe\u51c6\u6cbb\u7597\u836f\u7269\u7684\u9886\u5148\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4eca\u65e5\u516c\u5e03\u51762021\u5e74\u4e2d\u671f\u4e1a\u7ee9\u516c\u544a\u3002 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