{"id":42251,"date":"2021-08-26T18:45:00","date_gmt":"2021-08-26T11:45:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021082618450042251"},"modified":"2021-08-26T21:38:19","modified_gmt":"2021-08-26T13:38:19","slug":"%e5%a4%a9%e6%bc%94%e8%8d%af%e4%b8%9a%e5%85%ac%e5%b8%832021%e5%b9%b4%e4%b8%8a%e5%8d%8a%e5%b9%b4%e8%b4%a2%e5%8a%a1%e4%b8%9a%e7%bb%a9%e5%8f%8a%e5%85%ac%e5%8f%b8%e8%bf%9b%e5%b1%95","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021082618450042251","title":{"rendered":"\u5929\u6f14\u836f\u4e1a\u516c\u5e032021\u5e74\u4e0a\u534a\u5e74\u8d22\u52a1\u4e1a\u7ee9\u53ca\u516c\u53f8\u8fdb\u5c55"},"content":{"rendered":"<p><p><span class=\"xn-subheadline\">&#8211; \u4e0e\u9ed8\u6c99\u4e1c\u8fbe\u6210\u4e09\u9879\u4e34\u5e8a\u5408\u4f5c\uff0c\u4ee5\u63a8\u8fdb\u4e09\u4e2a\u4e34\u5e8a\u6297\u80bf\u7624\u5019\u9009\u4ea7\u54c1\u4e0e\u5e15\u535a\u5229\u73e0\u5355\u6297\u7684\u5168\u7403\u8054\u5408\u8bd5\u9a8c &#8211;<\/span><\/p>\n<p><span class=\"xn-subheadline\">&#8211; ADG106\u5355\u836f\u4e34\u5e8a\u8bd5\u9a8c\u663e\u793a\u7597\u6548\u4e14\u5b89\u5168\u6027\u826f\u597d\uff1b\u7740\u529b\u63a8\u8fdb\u751f\u7269\u6807\u5fd7\u7269\u9ad8\u8868\u8fbe\u7684\u9002\u5e94\u75c7\u53ca\u9776\u5411PD-1\u8010\u836f\u60a3\u8005\u7684\u8054\u5408\u6cbb\u7597-<\/span><\/p>\n<p><span class=\"xn-subheadline\">&#8211; \u6b63\u5728\u8fdb\u884c\u7684 I \u671f\u8bd5\u9a8c\u663e\u793a\u51fa\u5168\u65b0\u7684\u6297 CTLA-4\u65b0\u8868\u4f4d\u6297\u4f53\uff08NEObodyTM\uff09ADG116\u5177\u6709\u9ad8\u5ea6\u5dee\u5f02\u5316\u7684\u4e34\u5e8a\u4ea7\u54c1\u8868\u5f81 &#8211;<\/span><\/p>\n<p><span class=\"xn-subheadline\">-\u9996\u4e2a\u5b89\u5168\u6027\u6297\u4f53\u9879\u76eeADG126 I \u671f\u4e34\u5e8a\u5242\u91cf\u722c\u5761\u987a\u5229\u63a8\u8fdb-<\/span><\/p>\n<p><span class=\"xn-subheadline\">&#8211; 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mg\/kg\u7684\u5242\u91cf\u6269\u5c55\u4e2d\u5c55\u73b0\u4e86\u826f\u597d\u7684\u8010\u53d7\u6027\u3002\u4ec5\u89c2\u5bdf\u5230\u6709\u9650\u7684\u4e0d\u826f\u53cd\u5e94\uff08TEAEs\uff09\uff08\u5373\u6709\u9650\u7684\u809d\u6bd2\u6027\u6216\u8840\u6db2\u5b66\u5f02\u5e38\uff09\u3002\u7ed3\u679c\u663e\u793aADG106\u5355\u4e00\u7597\u6cd5\u7684\u75be\u75c5\u63a7\u5236\u7387\u4e3a56%\uff0c\u572875%\u7684\u751f\u7269\u6807\u5fd7\u7269\u9633\u6027\u60a3\u8005\u4e2d\uff08\u901a\u8fc7\u56de\u987e\u6027\u5206\u6790\uff09\u89c2\u5bdf\u5230\u8d85\u8fc730%\u7684\u80bf\u7624\u7f29\u5c0f\uff0c\u5e76\u4e14\u5728\u901a\u8fc7RECIST v1.1\u8bc4\u4f30\u7684\u4e00\u4f4d\u5148\u524d\u6cbb\u7597\u5931\u8d25\u7684\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u51fa\u73b0\u4e86\u90e8\u5206\u7f13\u89e3\u3002 <\/li>\n<li>\u4ee5\u4e0a\u6570\u636e\u5df2\u5728ASCO 2021\u5e74\u4f1a\u4e0a\u516c\u5e03\u3002<\/li>\n<\/ul>\n<li>Ib\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08ADG106-1008\uff09\u6b63\u5728\u5242\u91cf\u722c\u5761\u4e2d\uff0c\u4ee5\u8bc4\u4f30ADG106\u4e0e\u4e2d\u56fd\u5df2\u6279\u51c6\u7684\u6297PD&nbsp;-1\u836f\u7269\u7279\u745e\u666e\u5229\u5355\u6297\uff08toripalimab\uff09\u8054\u5408\u7597\u6cd5\u7684\u5b89\u5168\u6027\u548c\u521d\u6b65\u7597\u6548\u3002\u8fd9\u9879\u8bd5\u9a8c\u662f\u9488\u5bf9\u5148\u524d\u5728\u6807\u51c6\u7597\u6cd5\u548c\/\u6216\u514d\u75ab\u80bf\u7624\u6cbb\u7597\u4e2d\u5931\u8d25\uff0c\u4e14\u751f\u7269\u6807\u5fd7\u7269\u8868\u8fbe\u4e3a\u9633\u6027\u7684\u80bf\u7624\u60a3\u8005\u3002 <\/li>\n<ul type=\"circle\">\n<li>\u521d\u6b65\u6570\u636e\u8868\u660e\uff0c\u5242\u91cf\u4f9d\u8d56\u6027\u836f\u6548\u5b66\u751f\u7269\u6807\u5fd7\u7269\u6240\u663e\u793a\u7684\u9776\u70b9\u7ed3\u5408\u548c\u5355\u836f\u6cbb\u7597\u8bd5\u9a8c\u4e00\u81f4\u3002 <\/li>\n<li>\u5728\u7f8e\u56fd\u53ca\u4e9a\u592a\u5730\u533a\u8fdb\u884c\u7684ADG106\u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08pembrolizumab\uff09\u7684Ib\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08ADG106- P2001; KEYNOTE-D12\uff09\uff0c\u901a\u8fc7\u6574\u5408ADG106-2001\u8bd5\u9a8c\u7684\u65e9\u671f\u8ba1\u5212\uff0c\u5c06\u805a\u7126\u4e8e\u751f\u7269\u6807\u5fd7\u7269\u9ad8\u8868\u8fbe\u7684\u9002\u5e94\u75c7\u7814\u7a76\u3002\u6b64\u9879\u8bd5\u9a8c\u7684\u6570\u636e\u9884\u8ba1\u5c06\u4e8e2022\u5e74\u516c\u5e03\u3002<\/li>\n<\/ul>\n<li>ADG106 \u8fd1\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff1a <\/li>\n<ul type=\"circle\">\n<li>2021\u4e0b\u534a\u5e74&nbsp; <\/li>\n<ul type=\"square\">\n<li>\u6b63\u5728\u8fdb\u884c\u7684\u8054\u5408\u7279\u745e\u666e\u5229\u5355\u6297\u7684\u8bd5\u9a8c\u7ed3\u679c\uff08ADG106-1008\uff09 <\/li>\n<li>\u5728\u7f8e\u56fd\uff08ADG106-1001\uff09\u548c\u4e2d\u56fd\uff08ADG106-1002\uff09\u5355\u836f\u6cbb\u7597\u8bd5\u9a8c\u7684\u60a3\u8005\u5b8c\u6210\u968f\u8bbf<\/li>\n<\/ul>\n<li>2022 <\/li>\n<ul type=\"square\">\n<li>\u4e0e\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u8bd5\u9a8c\uff08ADG106-P2001\uff09\u7684\u7ed3\u679c<\/li>\n<\/ul>\n<\/ul>\n<\/ul>\n<p><b>ADG116<\/b><b>\uff1a<\/b>\u7531\u5929\u6f14\u65b0\u8868\u4f4d\u6297\u4f53\uff08NEObody&#x2122;\uff09\u6280\u672f\u751f\u6210\uff0c\u9776\u5411CTLA-4\u7684\u72ec\u7279\u8868\u4f4d\uff0c\u76ee\u524d\u6b63\u5728\u8bc4\u4f30\u665a\u671f\/\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u3002ADG116\u65e8\u5728\u901a\u8fc7\u6e05\u9664\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u4e2d\u7684\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09\u6765\u63d0\u9ad8\u7597\u6548\uff0c\u5e76\u901a\u8fc7\u67d4\u6027\u914d\u4f53\u963b\u65ad\u6765\u7ef4\u6301\u5176\u751f\u7406\u529f\u80fd\uff0c\u6709\u671b\u514b\u670d\u73b0\u6709\u7684\u6297CTLA-4\u7597\u6cd5\u5b58\u5728\u7684\u5b89\u5168\u6027\u95ee\u9898\u3002&nbsp;<\/p>\n<ul type=\"disc\">\n<li>\u5168\u7403&nbsp;I&nbsp;\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08ADG116-1003\uff09\u6b63\u5728\u5242\u91cf\u722c\u5761\u4e2d\uff0c\u4ee5\u8bc4\u4f30&nbsp;ADG116 \u5728\u665a\u671f\/\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff1a <\/li>\n<li>\u5728\u9ad8\u8fbe6 mg\/kg \u5242\u91cf\u7ec4ADG116\u6ca1\u6709\u8868\u73b0\u51fa\u5242\u91cf\u9650\u5236\u6bd2\u6027\uff08DLT\uff09\uff0c\u8fd9\u662f\u5df2\u4e0a\u5e02&nbsp;CTLA-4 \u7597\u6cd5\u5728\u591a\u4e2a\u9002\u5e94\u75c7\u4e0b\u6279\u51c6\u5242\u91cf\u6c34\u5e733 mg\/kg\u7684\u4e24\u500d\uff0c10 mg\/kg \u5242\u91cf\u7ec4\u5df2\u5f00\u59cb\u5165\u7ec4\u75c5\u4eba\u3002 <\/li>\n<ul type=\"disc\">\n<li>\u8be5\u8bd5\u9a8c\u6709\u671b\u5728\u4eca\u5e74\u6269\u5927\u961f\u5217\uff1a\u901a\u8fc7\u4e24\u7ec4\u8054\u5408\u961f\u5217\u8bc4\u4f30ADG116\u4e0e\u7279\u745e\u666e\u5229\u5355\u6297\u6216ADG106\u5728\u665a\u671f\/\u8f6c\u79fb\u6027\u5b9e\u4f53\u80bf\u7624\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u521d\u6b65\u7597\u6548\uff0c\u540c\u65f6\u6574\u5408\u4e86ADG106-1003\u8bd5\u9a8c\u7684\u65e9\u671f\u8ba1\u5212\u3002&nbsp; <\/li>\n<\/ul>\n<li>\u5df2\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\uff08IND\uff09\u6279\u51c6\uff0c\u7528\u4e8e\u5728\u4e2d\u56fd\u8fdb\u884c\u7684\u5355\u836f\u6cbb\u7597\u8bd5\u9a8c\uff08ADG116-1002\uff09\u3002 <\/li>\n<li>\u6709\u671b\u4e8e&nbsp;2022 \u5e74\u5728\u7f8e\u56fd\u548c\u4e9a\u592a\u5730\u533a\u5f00\u5c55\u5e76\u63a8\u8fdb&nbsp;ADG116 \u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u7684&nbsp;I\u671f\u8bd5\u9a8c\uff08ADG116-P001\uff1b<span id=\"spanHghlt5c44\">KEYNOTE-C97<\/span>\uff09\u3002 <\/li>\n<li>ADG116 \u8fd1\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff1a <\/li>\n<ul type=\"circle\">\n<li>2021\u4e0b\u534a\u5e74 <\/li>\n<ul type=\"square\">\n<li>ADG-116 \u5355\u836f\u6cbb\u7597\uff08ADG116-1003\uff09\u6301\u7eed\u5242\u91cf\u9012\u589e\u7684\u7ed3\u679c<\/li>\n<\/ul>\n<li>2022 <\/li>\n<ul type=\"square\">\n<li>\u8054\u5408\u961f\u5217\u5242\u91cf\u9012\u589e\u7684\u7ed3\u679c\uff0c\u5305\u62ec&nbsp;ADG116 \u5206\u522b\u4e0e\u7279\u745e\u666e\u5229\u5355\u6297\u548c&nbsp;ADG106 \u7684\u7ec4\u5408&nbsp;\uff08ADG116-1003\uff09 <\/li>\n<li>\u4e0e\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u8bd5\u9a8c\uff08ADG116-P001\uff09\u7684\u7ed3\u679c<\/li>\n<\/ul>\n<\/ul>\n<\/ul>\n<p><b>ADG126<\/b><b>\uff1a<\/b>&nbsp;\u7531\u5929\u6f14\u5b89\u5168\u6297\u4f53\uff08SAFEbody&#x2122;\uff09\u6280\u672f\u751f\u6210\uff0c\u9776\u5411CTLA-4\u7684\u72ec\u7279\u8868\u4f4d\uff0c\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u8868\u73b0\u4f18\u5f02\u5e76\u65e8\u5728\u63d0\u4f9b\u66f4\u9ad8\u7684\u5b89\u5168\u6027\u3002ADG126 \u4ec5\u5728\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09&nbsp;\u6761\u4ef6\u4e0b\u88ab\u6fc0\u6d3b\uff0c\u901a\u8fc7\u6709\u6548\u6e05\u9664\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09&nbsp;\u589e\u5f3a\u7597\u6548\uff0c\u5e76\u901a\u8fc7\u67d4\u6027\u914d\u4f53\u963b\u65ad\u6765\u7ef4\u6301\u5176\u751f\u7406\u529f\u80fd\uff0c\u663e\u8457\u63d0\u9ad8\u4e86\u6cbb\u7597\u7a97\u53e3\u5e76\u6709\u671b\u89e3\u51b3\u73b0\u6709&nbsp;CTLA-4 \u7597\u6cd5\u5b58\u5728\u7684\u5b89\u5168\u6027\u95ee\u9898\u3002<\/p>\n<ul type=\"disc\">\n<li>\u5168\u7403&nbsp;I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08ADG126-1001\uff09\u6b63\u5728\u5242\u91cf\u722c\u5761\u4e2d\uff0c\u4ee5\u8bc4\u4f30&nbsp;ADG126 \u5728\u665a\u671f\/\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002 <\/li>\n<li>2021 \u5e74&nbsp;4 \u6708\uff0c\u5929\u6f14\u5728&nbsp;AACR \u5e74\u4f1a\u4e0a\u516c\u5e03\u4e86ADG126\u6700\u65b0\u4e34\u5e8a\u524d\u6570\u636e\u3002\u6570\u636e\u8868\u660e&nbsp;ADG126 \u4f5c\u4e3a\u5355\u4e00\u7597\u6cd5\u548c\u4e0e\u6297&nbsp;PD-1 \u548c\u5176\u4ed6\u8054\u5408\u7597\u6cd5\uff0c\u5728\u9ad8\u8fbe&nbsp;200 mg\/kg \u7684\u5242\u91cf\u4e0b\u4ecd\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u5e76\u5728\u591a\u79cd\u514d\u75ab\u5065\u5168\u7684\u5c0f\u9f20\u80bf\u7624\u6a21\u578b\u4e2d\u8868\u73b0\u51fa\u4f18\u5f02\u7684\u6297\u80bf\u7624\u7597\u6548\u3002 <\/li>\n<li>\u5411&nbsp;NMPA \u5206\u522b\u63d0\u4ea4\u4e86&nbsp;ADG126 \u4f5c\u4e3a\u5355\u836f\u6cbb\u7597\u53ca\u4e0e\u83b7\u6279\u7684\u6297&nbsp;PD-1 \u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u6cbb\u7597\u7684I&nbsp;\u671f\u3001\u5242\u91cf\u9012\u589e\u548c\u961f\u5217\u6269\u5c55\u7684\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\uff08ADG126-1002\uff09\u7533\u8bf7\uff0c\u4ee5\u8bc4\u4f30\u5728\u665a\u671f\/\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u521d\u6b65\u7597\u6548\u3002 <\/li>\n<li>\u6709\u671b\u4e8e&nbsp;2022 \u5e74\u5728\u7f8e\u56fd\u548c\u4e9a\u592a\u5730\u533a\u63a8\u8fdb&nbsp;ADG126 \u8054\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u7684&nbsp;I\u671f\u8bd5\u9a8c\uff08ADG126-P001\uff1bKEYNOTE-C98\uff09\u3002&nbsp; <\/li>\n<li>ADG126 \u8fd1\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff1a <\/li>\n<ul type=\"circle\">\n<li>2021\u4e0b\u534a\u5e74 <\/li>\n<ul type=\"square\">\n<li>ADG126 \u5355\u836f\u6cbb\u7597\uff08ADG126-1001\uff09\u5242\u91cf\u9012\u589e\u7684\u7ed3\u679c<\/li>\n<\/ul>\n<li>2022 <\/li>\n<ul type=\"square\">\n<li>ADG126\uff08ADG126-1002\uff09\u5242\u91cf\u9012\u589e\u548c\u961f\u5217\u6269\u5c55\u7684\u7ed3\u679c <\/li>\n<li>\u4e0e\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u8bd5\u9a8c\uff08ADG126-P001\uff09\u7684\u7ed3\u679c<\/li>\n<\/ul>\n<\/ul>\n<\/ul>\n<p><b>\u4e34\u5e8a\u524d\u7814\u53d1\u9879\u76ee\uff1a<\/b>\u51ed\u501f\u5929\u6f14\u65b0\u8868\u4f4d\u6297\u4f53NEObody&#x2122;\u3001\u5b89\u5168\u6297\u4f53SAFEbody&#x2122;\u548c\/\u6216\u5f3a\u529b\u6297\u4f53POWERbody&#x2122;&nbsp;\u6280\u672f\u7ee7\u7eed\u6269\u5927\u548c\u63a8\u8fdb\u521b\u65b0\u7684\u4e34\u5e8a\u524d\u7ba1\u7ebf\uff0c\u4ee5\u5b9e\u73b0\u5728\u672a\u6765\u4e09\u5230\u4e94\u5e74\u5185\u63d0\u4ea4\u8d85\u8fc710\u4e2a&nbsp;IND \u6216\u5176\u4ed6\u540c\u7c7b\u7533\u8bf7\u7684\u76ee\u6807\u3002&nbsp; <\/p>\n<p>\u76ee\u524d\uff0c\u51ed\u501f&nbsp;POWERbody&#x2122; \u548c&nbsp;SAFEbody&#x2122;&nbsp;\u6280\u672f\u751f\u6210\u7684\u4e94\u4e2a\u9879\u76ee\u6b63\u5728\u65b0\u836f\u7533\u8bf7\u7684\u4e34\u5e8a\u524d\u7814\u7a76\uff08IND\uff09\u9636\u6bb5\uff0c\u5305\u62ec\u9ad8\u5ea6\u5dee\u5f02\u5316\u7684\u6297&nbsp;CD47 \u9879\u76ee\uff0c\u4ee5\u53ca\u9488\u5bf9\u8840\u6db2\u53ca\u5b9e\u4f53\u80bf\u7624\u7684\u53cc\u7279\u5f02\u6027\u7684T\u7ec6\u80de\u8854\u63a5\u6297\u4f53\uff08Bispecific T cell engager\uff09\u3002<\/p>\n<ul type=\"disc\">\n<li>\u4e94\u4e2a\u9879\u76ee\u90fd\u5177\u6709\u826f\u597d\u7684\u6210\u836f\u6027\uff08CMC\u6027\u8d28\uff09\uff0c\u5e76\u62e5\u6709\u4ee4\u4eba\u9f13\u821e\u7684\u4e34\u5e8a\u524d\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6570\u636e\u3002 <\/li>\n<li>\u81ea&nbsp;2021 \u5e74&nbsp;3 \u6708&nbsp;31 \u65e5\u8d77\uff0c\u516c\u53f8\u5df2\u5c06\u53e6\u5916\u4e24\u4e2a\u9879\u76ee\u63a8\u8fdb\u81f3&nbsp;CMC\u9636\u6bb5\uff0c\u8fdb\u4e00\u6b65\u52a0\u5f3a\u4e86\u672a\u6765&nbsp;IND \u7684\u5019\u9009\u4ea7\u54c1\u7ec4\u5408\u3002 <\/li>\n<li>\u4e34\u5e8a\u524d\u4ea7\u54c1\u7684\u8fd1\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff1a&nbsp; <\/li>\n<ul type=\"circle\">\n<li>2021 <\/li>\n<ul type=\"square\">\n<li>\u7ee7\u7eed\u63a8\u8fdb\u6b63\u5728\u65b0\u836f\u7533\u8bf7\u7684\u4e34\u5e8a\u524d\u7814\u7a76\uff08IND\uff09\u9636\u6bb5\u7684\u591a\u4e2a\u5019\u9009\u4ea7\u54c1<\/li>\n<\/ul>\n<li>2022 <\/li>\n<ul type=\"square\">\n<li>\u63d0\u4ea4\u591a\u4e2a&nbsp;IND\u6216\u5176\u4ed6\u540c\u7c7b\u7533\u8bf7&nbsp;\uff0c\u5e76\u4ece\u516c\u53f8\u9ad8\u5ea6\u5dee\u5f02\u5316\u7684\u53d8\u9769\u6027\u4e34\u5e8a\u524d\u7ba1\u7ebf\u4e2d\u63a8\u8fdb\u5f00\u53d1\u65b0\u7684\u5019\u9009\u4ea7\u54c1<\/li>\n<\/ul>\n<\/ul>\n<\/ul>\n<p><b>\u5546\u4e1a\u5408\u4f5c\u9879\u76ee<\/b>&nbsp;<\/p>\n<ul type=\"disc\">\n<li>\u4e0e\u9ed8\u6c99\u4e1c\u5c31\u4e09\u4e2a\u4e34\u5e8a\u5019\u9009\u4ea7\u54c1\u5efa\u7acb\u4e86\u4e34\u5e8a\u8bd5\u9a8c\u5408\u4f5c\u548c\u4f9b\u836f\u534f\u8bae\uff1a <\/li>\n<ul type=\"circle\">\n<li>2021 \u5e74&nbsp;7 \u6708\uff0c\u5929\u6f14\u4e0e\u514d\u75ab\u80bf\u7624\u5b66\u9886\u57df\u7684\u9886\u5bfc\u8005\u9ed8\u6c99\u4e1c\u516c\u53f8\u8fbe\u6210\u4e86\u4e24\u9879\u4e34\u5e8a\u8bd5\u9a8c\u5408\u4f5c\u3002\u53cc\u65b9\u5c31\u5929\u6f14\u836f\u4e1a\u7684\u6297&nbsp;CTLA-4 \u5355\u514b\u9686\u6297\u4f53\uff08mAb\uff09\u5019\u9009\u4ea7\u54c1&nbsp;ADG116 \u548c&nbsp;ADG126\u4e0e\u9ed8\u6c99\u4e1c\u7684\u6297&nbsp;PD-1 \u836f\u7269KEYTRUDA&reg;\uff08\u5e15\u535a\u5229\u73e0\u5355\u6297\uff09\u7684\u8054\u5408\u6cbb\u7597\u5c06\u542f\u52a8\u4e24\u9879\u5f00\u653e\u6807\u7b7e\u3001\u5242\u91cf\u9012\u589e\u4e0e\u62d3\u5c55\u7814\u7a76\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ee5\u8bc4\u4f30\u8be5\u8054\u5408\u7528\u836f\u5728\u665a\u671f\/\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u7684\u4e34\u5e8a\u7597\u6548\u3002 <\/li>\n<li>2021 \u5e74&nbsp;8 \u6708\uff0c\u5929\u6f14\u4e0e\u9ed8\u6c99\u4e1c\u516c\u53f8\u5408\u4f5c\u5f00\u5c55\u7b2c\u4e09\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30\u5929\u6f14\u6297CD137\u6fc0\u52a8\u578b\u5355\u514b\u9686\u6297\u4f53ADG106\u4e0e\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u7528\u836f\u5728\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u548c\/\u6216\u8840\u6db2\u6076\u6027\u80bf\u7624\u60a3\u8005\u4e2d\u7684\u4e34\u5e8a\u7597\u6548\u3002<\/li>\n<\/ul>\n<li>\u4e0e\u6842\u6797\u4e09\u91d1\u836f\u4e1a\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0\u201c\u4e09\u91d1\u201d\uff09\u53ca\u5176\u9644\u5c5e\u516c\u53f8\u5408\u4f5c\u5f00\u53d1\u4e24\u6b3e\u4e0d\u540c\u9776\u70b9\u7684\u5355\u514b\u9686\u6297\u4f53\uff1a <\/li>\n<ul type=\"circle\">\n<li>ADG104 \u4e3a\u9776\u5411&nbsp;PD-L1\u7684\u5355\u514b\u9686\u6297\u4f53\uff0c\u5728\u4e2d\u56fd\u540c\u65f6\u8fdb\u884c\u7684&nbsp;Ib \u671f\u548c&nbsp;II&nbsp;\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u89c2\u5bdf\u5230\u79ef\u6781\u7684\u4e34\u5e8a\u6570\u636e\u3002\u622a\u81f3&nbsp;2021 \u5e74&nbsp;6 \u6708&nbsp;30 \u65e5\uff0c4 \u540d\u60a3\u8005\u90e8\u5206\u7f13\u89e3\uff0c16 \u540d\u60a3\u8005\u75c5\u60c5\u7a33\u5b9a\uff0c\u5728\u63a5\u53d7&nbsp;ADG104 \u5355\u836f\u6cbb\u7597\u7684&nbsp;40 \u540d\u53ef\u8bc4\u4f30\u80bf\u7624\u60a3\u8005\u4e2d\uff0c\u75be\u75c5\u63a7\u5236\u7387\u4e3a50%\u3002 <\/li>\n<li>\u53cc\u65b9\u5408\u4f5c\u5f00\u53d1\u7684\u7b2c\u4e8c\u6b3e\u4ea7\u54c1\u4e3a\u9776\u5411CSF-1R \u7684\u5355\u514b\u9686\u6297\u4f53\uff0c\u4e8e2021\u5e743 \u6708\u83b7\u5f97\u4e86&nbsp;NMPA \u7684&nbsp;IND \u6279\u51c6\uff0c\u9884\u8ba1\u5f88\u5feb\u5165\u7ec4\u7b2c\u4e00\u4f8b\u75c5\u4eba\u3002<\/li>\n<\/ul>\n<\/ul>\n<p><b>\u516c\u53f8\u6700\u65b0\u52a8\u6001<\/b><\/p>\n<ul type=\"disc\">\n<li>\u516c\u53f8\u5ba3\u5e03\uff0c\u5bf9\u8463\u4e8b\u4f1a\u7ec4\u6210\u8fdb\u884c\u4ee5\u4e0b\u53d8\u66f4\uff0c\u5373\u65e5\u751f\u6548\u3002\u7531JSR Limited \u6839\u636e\u5f53\u524d\u6709\u6548\u7684\u80a1\u4e1c\u534f\u8bae\u6307\u5b9a\u7684\u8463\u4e8b\u7f2a\u5b87\u5148\u751f\uff0c\u56e0\u4e2a\u4eba\u539f\u56e0\u5df2\u8f9e\u53bb\u8463\u4e8b\u4f1a\u804c\u52a1\u3002\u7f2a\u5b87\u5148\u751f\u786e\u8ba4\u4e0e\u516c\u53f8\u5e76\u65e0\u5206\u6b67\u3002&nbsp;\u516c\u53f8\u611f\u8c22\u7f2a\u5b87\u5148\u751f\u5728\u4efb\u671f\u95f4\u7684\u52e4\u52c9\u5de5\u4f5c\u548c\u5bf9\u8463\u4e8b\u4f1a\u7684\u5b9d\u8d35\u8d21\u732e\u3002 <\/li>\n<li>\u8fdb\u4e00\u6b65\u6269\u5927\u9886\u5bfc\u56e2\u961f\uff1a <\/li>\n<ul type=\"circle\">\n<li>Steven Fischkoff\u533b\u5b66\u535a\u58eb\u88ab\u4efb\u547d\u4e3a\u4ee3\u7406\u9996\u5e2d\u533b\u5b66\u5b98\u3002\u4f5c\u4e3a\u4e00\u540d\u83b7\u5f97\u8ba4\u8bc1\u7684\u533b\u5b66\u80bf\u7624\u5b66\u5bb6\uff0cFischkoff \u535a\u58eb\u5df2\u5728\u5236\u836f\u884c\u4e1a\u6df1\u801530\u5e74\u3002\u6b64\u524d\u5728Medarex\u5de5\u4f5c\u671f\u95f4\uff0cFischkoff\u535a\u58eb\u8d1f\u8d23Yervoy&reg;\uff08\u4f0a\u5339\u5355\u6297\uff09\u7684\u4e34\u5e8a\u7814\u53d1\u3002\u4f0a\u5339\u5355\u6297\u662f\u9996\u4e2a\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff0c\u4e14\u662f\u8fc4\u4eca\u4e3a\u6b62\u552f\u4e00\u88abFDA\u6279\u51c6\u7684\u6297CTLA-4\u4ea7\u54c1\u3002\u5728Knoll\u5236\u836f\u548c\u7f8e\u56fd\u96c5\u57f9\u4efb\u804c\u671f\u95f4\uff0cFischkoff\u535a\u58eb\u66fe\u6210\u529f\u9886\u5bfc\u5168\u7403\u6700\u7545\u9500\u7684\u836f\u54c1Humira&reg;\uff08\u963f\u8fbe\u6728\u5355\u6297\uff09\u4eceI\u671f\u4e34\u5e8a\u8bd5\u9a8c\u81f3\u6700\u7ec8\u63d0\u4ea4\u4e0a\u5e02\u7533\u8bf7\uff0c\u5e76\u5728\u7f8e\u56fd\u548c\u6b27\u76df\u83b7\u5f97\u6279\u51c6\u3002 <\/li>\n<li>\u5c1a\u8fdb\u535a\u58eb\u88ab\u4efb\u547d\u4e3a\u5168\u7403\u6ce8\u518c\u53ca\u6cd5\u89c4\u4e8b\u52a1\u9ad8\u7ea7\u526f\u603b\u88c1\u3002\u5c1a\u535a\u58eb\u5728\u751f\u7269\u5236\u836f\u884c\u4e1a\u62e5\u670920\u591a\u5e74\u7684\u836f\u7269\u7814\u53d1\u548c\u76d1\u7ba1\u7ecf\u9a8c\u3002\u52a0\u5165\u5929\u6f14\u4e4b\u524d\u66fe\u62c5\u4efb\u963f\u65af\u5229\u5eb7\u80bf\u7624\u533b\u836f\u90e8\u6cd5\u89c4\u4e8b\u52a1\u603b\u76d1\uff0c\u66f4\u65e9\u4e4b\u524d\u5206\u522b\u5728Sun Pharma, Morphic Therapeutics\u548c\u9ed8\u6c99\u4e1c\u4efb\u804c\u3002 <\/li>\n<li>\u66fe\u6587\u6797\u535a\u58eb\u88ab\u4efb\u547d\u4e3a\u7ec6\u80de\u682a<span id=\"spanHghltca71\">\u53ca<\/span>\u4e0a<span id=\"spanHghlt1ccd\">\u6e38\u5f00<\/span>\u53d1\u526f\u603b\u88c1\u3002\u66fe\u535a\u58eb\u5c06\u8d1f\u8d23\u7ec6\u80de\u682a\u6784\u5efa\u548c\u4e0a\u6e38\u751f\u4ea7\u5de5\u827a\u5f00\u53d1\uff0c\u5e76\u76d1\u7ba1\u540e\u7eed\u751f\u7269\u5236\u5242\u751f\u4ea7\u5de5\u4f5c\u3002&nbsp;\u66fe\u535a\u58eb\u5728\u7ec6\u80de\u682a\u5f00\u53d1\u3001cGMP \u7ec6\u80de\u5e93\u6784\u5efa\u548c\u539f\u6599\u836f\u5236\u9020\u65b9\u9762\u62e5\u6709&nbsp;20 \u591a\u5e74\u7684\u7ecf\u9a8c\u3002&nbsp;\u52a0\u5165\u5929\u6f14\u4e4b\u524d\u5979\u66fe\u62c5\u4efb&nbsp;Gilead \u7684\u9ad8\u7ea7\u603b\u76d1\uff0c\u66f4\u65e9\u4e4b\u524d\u66fe\u5728Forty-Seven\u3001NGM Bio\u3001Advanced Bioscience Laboratories\u3001\u845b\u5170\u7d20\u53f2\u514b\u3001MedImmune Vaccines\u3001Abgenix \u548c&nbsp;Scios \u4efb\u804c\u3002 <\/li>\n<li>Ami C. Knoefler\u88ab\u4efb\u547d\u4e3a\u6295\u8d44\u8005\u5173\u7cfb\u548c\u4f01\u4e1a\u4f20\u64ad\u526f\u603b\u88c1\u3002\u5979\u5728\u8de8\u56fd\u5236\u836f\u516c\u53f8\u3001\u751f\u7269\u836f\u4f01\u53ca\u533b\u7597\u884c\u4e1a\u7684\u4f20\u64ad\u9886\u57df\u62e5\u6709\u8d85\u8fc7&nbsp;25 \u5e74\u7684\u7ecf\u9a8c\u3002\u52a0\u5165\u5929\u6f14\u4e4b\u524d\uff0c\u5979\u66fe\u62c5\u4efbAscendis Pharma\u7684\u9ad8\u7ea7\u603b\u76d1\uff0c\u66f4\u65e9\u4e4b\u524d\u5206\u522b\u5728Jazz Pharmaceuticals\u3001PDL BioPharma\u3001Abgenix \u548c&nbsp;Bristol-Myers Squibb \u4efb\u804c\u3002<\/li>\n<\/ul>\n<li>\u516c\u53f8\u4efb\u547d\u4e86\u79d1\u5b66\u4e0e\u6218\u7565\u987e\u95ee\u59d4\u5458\u4f1a\u65b0\u6210\u5458\uff0c\u4ed6\u4eec\u5206\u522b\u662f\uff1aSteven Fischkoff\u533b\u5b66\u535a\u58eb\u3001Stanley Frankel\u533b\u5b66\u535a\u58eb\uff0cFACP\uff0c\u4ee5\u53caRobert Spiegel\u533b\u5b66\u535a\u58eb\uff0cFACP\u3002\u5929\u6f14\u79d1\u5b66\u4e0e\u6218\u7565\u987e\u95ee\u59d4\u5458\u4f1a\u7531\u591a\u4f4d\u5728\u80bf\u7624\u514d\u75ab\u9886\u57df\u4f5c\u51fa\u91cd\u8981\u8d21\u732e\u7684\u79d1\u5b66\u5bb6\u53ca\u4e34\u5e8a\u4e13\u5bb6\u7ec4\u6210\uff0c\u4ed6\u4eec\u5c06\u4e0e\u5929\u6f14\u7ba1\u7406\u56e2\u961f\u53ca\u5176\u4ed6\u4e34\u5e8a\u7814\u7a76\u8005\u7d27\u5bc6\u534f\u4f5c\uff0c\u4e3a\u516c\u53f8\u53d8\u9769\u6027\u7814\u53d1\u7ba1\u7ebf\u7684\u5168\u7403\u5f00\u53d1\u63d0\u4f9b\u6218\u7565\u652f\u6301\u3002 <\/li>\n<li>\u4eca\u5e747\u6708\uff0c\u516c\u53f8\u8463\u4e8b\u4f1a\u6279\u51c6\u4e86\u4e00\u9879\u80a1\u7968\u56de\u8d2d\u8ba1\u5212\uff0c\u6388\u6743\u5929\u6f14\u4ee5\u7f8e\u56fd\u5b58\u6258\u80a1\u7968\uff08ADS\uff09\u7684\u5f62\u5f0f\u53ef\u4ee5\u56de\u8d2d\u603b\u4ef7\u503c\u4e0d\u8d85\u8fc72000\u4e07\u7f8e\u5143\u7684\u7f8e\u56fd\u5b58\u6258\u80a1\u7968\u3002<\/li>\n<\/ul>\n<p><b>2021<\/b><b>\u5e74\u4e0a\u534a\u5e74\u8d22\u52a1\u4eae\u70b9<\/b><b>&nbsp;<\/b><\/p>\n<p><u>\u73b0\u91d1\u548c\u73b0\u91d1\u7b49\u4ef7\u7269<\/u><\/p>\n<p>\u622a\u81f32021\u5e746\u670830\u65e5\uff0c\u73b0\u91d1\u548c\u73b0\u91d1\u7b49\u4ef7\u7269\u4e3a2.083\u4ebf\u7f8e\u5143\uff0c\u800c\u622a\u81f32020\u5e7412\u670831\u65e5\u4e3a7,515\u4e07\u7f8e\u5143\u3002\u73b0\u91d1\u548c\u73b0\u91d1\u7b49\u4ef7\u7269\u589e\u52a0\u7684\u4e3b\u8981\u539f\u56e0\u662f\u516c\u53f82021\u5e742\u6708\u9996\u6b21\u516c\u5f00\u52df\u80a1\u7684\u51c0\u96c6\u8d44\u989d\u4e3a1.459\u4ebf\u7f8e\u5143\u3002\u6b64\u5916\uff0c\u516c\u53f8\u6839\u636e\u5408\u4f5c\u548c\u8bb8\u53ef\u534f\u8bae\u6761\u6b3e\uff0c\u4e8e2021 \u5e74&nbsp;3 \u6708\u4ece&nbsp;Exelixis \u6536\u52301,100 \u4e07\u7f8e\u5143\u7684\u9996\u4ed8\u6b3e\u3002<\/p>\n<p><u>\u9884\u4ed8\u6b3e\u548c\u5176\u4ed6\u6d41\u52a8\u8d44\u4ea7<\/u><\/p>\n<p>\u622a\u81f32021\u5e74&nbsp;6\u670830\u65e5\uff0c\u9884\u4ed8\u6b3e\u548c\u5176\u4ed6\u6d41\u52a8\u8d44\u4ea7\u4e3a539\u4e07\u7f8e\u5143\uff0c\u800c\u622a\u81f32020\u5e7412\u670831\u65e5\u4e3a381\u4e07\u7f8e\u5143\u3002\u63a8\u52a8\u8be5\u589e\u957f\u7684\u539f\u56e0\u662f\u7814\u53d1\u4e1a\u52a1\u6269\u5c55\u4ee5\u53ca\u5176\u6240\u5e26\u6765\u7684\u76f8\u5173\u9884\u4ed8\u6b3e\u7684\u589e\u52a0\u3002<\/p>\n<p><u>\u5408\u540c\u8d1f\u503a<\/u><\/p>\n<p>\u622a\u81f32021\u5e746\u670830\u65e5\uff0c\u5408\u540c\u8d1f\u503a\u4e3a1,110\u4e07\u7f8e\u5143\uff0c\u800c\u622a\u81f32020\u5e7412\u670831\u65e5\u4e3a73\u4e07\u7f8e\u5143\u3002\u5408\u540c\u8d1f\u503a\u589e\u52a0\u7684\u539f\u56e0\u662f2021\u5e743\u6708\u4eceExelixis\u6536\u52301,100 \u4e07\u7f8e\u5143\u7684\u9996\u4ed8\u6b3e\u5c1a\u672a\u8fbe\u5230\u6536\u5165\u786e\u8ba4\u7684\u76f8\u5173\u5c65\u7ea6\u4e49\u52a1\u3002<\/p>\n<p><u>\u51c0\u6536\u5165<\/u><\/p>\n<p>\u622a\u81f32021\u5e746\u670830\u65e5\u6b62\u516d\u4e2a\u6708\u51c0\u6536\u5165\u4e3a136\u4e07\u7f8e\u5143\uff0c\u800c2020\u5e74\u540c\u671f\u4e3a31\u4e07\u7f8e\u5143\u3002\u51c0\u6536\u5165\u7684\u4e3b\u8981\u589e\u957f\u6765\u6e90\u662f\u516c\u53f8\u6536\u5230\u7531\u6842\u6797\u4e09\u91d1\u5b50\u516c\u53f8\u5b9d\u8239\u751f\u7269\u533b\u836f\u79d1\u6280\uff08\u201c\u5b9d\u8239\u201d\uff09\u6240\u652f\u4ed8\u7684120\u4e07\u7f8e\u5143\u3002\u8be5\u7b14\u6536\u5165\u7684\u786e\u8ba4\u662f\u57fa\u4e8e\u516c\u53f8\u5df2\u7ecf\u5b8c\u5168\u5c65\u884c\u4e0e\u5b9d\u8239\u5408\u4f5c\u5f00\u53d1\u6297\u4f53\u7597\u6cd5\u76f8\u5173\u7684\u5c65\u7ea6\u4e49\u52a1\u3002<\/p>\n<p><u>\u7814\u53d1<\/u><u>\uff08<\/u><u>R&amp;D<\/u><u>\uff09<\/u><u>\u8d39\u7528<\/u><u>&nbsp;<\/u><\/p>\n<p>\u622a\u81f32021\u5e746\u670830\u65e5\u6b62\u516d\u4e2a\u6708\u7684\u7814\u53d1\u8d39\u7528\u4e3a3,146\u4e07\u7f8e\u5143\uff0c\u800c2020\u5e74\u540c\u671f\u4e3a1,491\u4e07\u7f8e\u5143\u3002\u7814\u53d1\u8d39\u7528\u589e\u52a0\u7684\u4e3b\u8981\u539f\u56e0\u662f\uff1a(i) \u56e0\u7814\u53d1\u4eba\u5458\u4eba\u6570\u548c\u5e73\u5747\u85aa\u916c\u6c34\u5e73\u7684\u589e\u957f,\u5de5\u8d44\u548c\u5176\u4ed6\u76f8\u5173\u4eba\u529b\u6210\u672c\u589e\u52a0430\u4e07\u7f8e\u5143\uff1b(ii) \u4e0e\u7814\u53d1\u4eba\u5458\u76f8\u5173\u7684\u80a1\u6743\u6fc0\u52b1\u8d39\u7528\u652f\u51fa\u589e\u52a0310\u4e07\u7f8e\u5143\uff1b\u4ee5\u53ca(iii) \u56e0\u9879\u76ee\u8fdb\u5c55\u548c\u5408\u540c\u5236\u9020\u6210\u672c\u589e\u52a0\uff0c\u4e34\u5e8a\u524d\u68c0\u6d4b\u548c\u4e34\u5e8a\u8bd5\u9a8c\u7684\u76f8\u5173\u6210\u672c\u589e\u52a0800\u4e07\u7f8e\u5143\u3002\u5728\u622a\u81f32021\u5e746\u670830\u65e5\u7684\u516d\u4e2a\u6708\u4e2d\uff0c\u5929\u6f14\u4e3aADG106\u3001ADG116\u548cADG126\u9879\u76ee\u5171\u652f\u4ed8\u4e861,660\u4e07\u7f8e\u5143\uff0c\u800c2020\u5e74\u540c\u671f\u4e3a1,300\u4e07\u7f8e\u5143\u3002\u6b64\u5916\uff0c\u516c\u53f8\u5728\u622a\u81f3&nbsp;2021 \u5e74&nbsp;6 \u6708&nbsp;30 \u65e5\u7684\u516d\u4e2a\u6708\u5185\u56e0\u4e34\u5e8a\u524d\u5019\u9009\u836f\u7269\u3001\u7814\u53d1\u7ba1\u7ebf\u53ca\u5176\u4ed6\u9879\u76ee\u5171\u4ea7\u751f\u8d39\u7528&nbsp;1,480 \u4e07\u7f8e\u5143\uff0c\u800c2020 \u5e74\u540c\u671f\u7684\u8be5\u91d1\u989d\u4e3a&nbsp;190 \u4e07\u7f8e\u5143\u3002<\/p>\n<p><u>\u7ba1\u7406\uff08<\/u><u>G&amp;A<\/u><u>\uff09<\/u><u>\u8d39\u7528<\/u><u>&nbsp;<\/u><\/p>\n<p>\u622a\u81f32021\u5e746\u670830\u65e5\u6b62\u516d\u4e2a\u6708\u5185\uff0c\u7ba1\u7406\u8d39\u7528\u4e3a740\u4e07\u7f8e\u5143\uff0c\u800c2020\u5e74\u540c\u671f\u4e3a473\u4e07\u7f8e\u5143\u3002\u589e\u52a0\u7684\u4e3b\u8981\u539f\u56e0\u662f\uff1a(i) \u884c\u653f\u7ba1\u7406\u4eba\u5458\u4eba\u6570\u548c\u5e73\u5747\u85aa\u916c\u6c34\u5e73\u7684\u589e\u52a0\uff1b\u4ee5\u53ca(ii) \u4e13\u4e1a\u8d39\u7528\u548c\u529e\u516c\u5ba4\u8d39\u7528\u7684\u589e\u52a0\u3002<\/p>\n<p><u>\u51c0\u4e8f\u635f<\/u><\/p>\n<p>\u622a\u81f32021\u5e746\u670830\u65e5\u6b62\u516d\u4e2a\u6708\u5185\uff0c\u5f52\u5c5e\u4e8e\u5929\u6f14\u836f\u4e1a\u80a1\u4e1c\u7684\u51c0\u4e8f\u635f\u4e3a3,719\u4e07\u7f8e\u5143\uff0c\u800c\u622a\u81f32020\u5e746\u670830\u65e5\u6b62\u516d\u4e2a\u6708\u4e3a1,819\u4e07\u7f8e\u5143\u3002<\/p>\n<p><u>\u975e<\/u><u>\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1<\/u><u>\u51c6\u5219\uff08<\/u><u>Non-GAAP<\/u><u>\uff09\u4e0b\u7684\u51c0\u635f\u4e8f\u635f<\/u><\/p>\n<p>\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u4e0b\u7684\u51c0\u4e8f\u635f\u5b9a\u4e49\u4e3a\u8be5\u671f\u95f4\u7684\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u4e0b\u7684\u51c0\u4e8f\u635f\u5254\u9664\u4ee5\u4e0b\u9879\u76ee\uff1a(i) \u80a1\u6743\u6fc0\u52b1\u8d39\u7528\uff1b\u4ee5\u53ca&nbsp;(ii) \u53ef\u8f6c\u6362\u53ef\u8d4e\u56de\u4f18\u5148\u80a1\u589e\u52a0\u81f3\u53ef\u8d4e\u56de\u4ef7\u503c\u3002\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff08Non-GAAP\uff09\u4e0b\u7684\u51c0\u635f\u4e8f\u635f\u5728\u622a\u6b62\u81f3&nbsp;2021 \u5e74&nbsp;6 \u6708&nbsp;30 \u65e5\u7684\u516d\u4e2a\u6708\u5185\u7d2f\u8ba1\u4e3a&nbsp;2,704 \u4e07\u7f8e\u5143\uff0c\u800c&nbsp;2020\u5e74\u540c\u671f\u4e3a&nbsp;1,109 \u4e07\u7f8e\u5143\u3002\u8bf7\u53c2\u9605\u672c\u65b0\u95fb\u7a3f\u4e2d\u9898\u4e3a\u201c\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff08GAAP\uff09\u548c\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff08Non-GAAP\uff09\u4e0b\u7684\u4e1a\u7ee9\u8c03\u8282\u8868\u201d\u90e8\u5206\u4e86\u89e3\u8be6\u60c5\u3002<\/p>\n<p><b>\u5bf9\u4e8e\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff08Non-GAAP\uff09\u8d22\u52a1\u6307\u6807\u7684\u8861\u91cf<\/b><\/p>\n<p>\u5929\u6f14\u836f\u4e1a\u4f7f\u7528Non-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\uff0c\u7528\u4e8e\u8bc4\u4f30\u672c\u516c\u53f8\u7684\u7ecf\u8425\u6210\u679c\uff0c\u4ee5\u53ca\u8d22\u52a1\u548c\u7ecf\u8425\u51b3\u7b56\u3002\u672c\u516c\u53f8\u8ba4\u4e3a\uff0cNon-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\u6709\u52a9\u4e8e\u8bc6\u522b\u672c\u516c\u53f8\u4e1a\u52a1\u7684\u57fa\u672c\u8d8b\u52bf\uff0c\u800c\u8fd9\u4e9b\u8d8b\u52bf\u53ef\u80fd\u56e0\u672c\u516c\u53f8\u8ba1\u5165\u672c\u5e74\u5ea6\/\u671f\u95f4\u4e8f\u635f\u7684\u67d0\u4e9b\u8d39\u7528\u7684\u5f71\u54cd\u800c\u626d\u66f2\u3002\u672c\u516c\u53f8\u8ba4\u4e3a\uff0cNon-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\u63d0\u4f9b\u4e86\u6709\u5173\u5176\u7ecf\u8425\u6210\u679c\u7684\u6709\u7528\u4fe1\u606f\uff0c\u6574\u4f53\u63d0\u5347\u4e86\u5bf9\u5176\u8fc7\u53bb\u4e1a\u7ee9\u548c\u672a\u6765\u524d\u666f\u7684\u5168\u9762\u4e86\u89e3\uff0c\u5e76\u4f7f\u7ba1\u7406\u5c42\u5728\u8d22\u52a1\u548c\u8fd0\u8425\u51b3\u7b56\u4e2d\u4f7f\u7528\u7684\u5173\u952e\u6307\u6807\u66f4\u5177\u53ef\u89c1\u6027\u3002<\/p>\n<p>\u5bf9\u4e8e\u672c\u5e74\u5ea6\/\u671f\u95f4\u7684Non-GAAP\u8d22\u52a1\u6307\u6807\u7684\u8861\u91cf\uff0c\u5929\u6f14\u836f\u4e1a\u4f7f\u7528\u7684Non-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\u4e0d\u5e94\u5355\u72ec\u88ab\u8003\u8651\uff0c\u4e5f\u4e0d\u5e94\u88ab\u89c6\u4e3a\u8be5\u5e74\u5ea6\/\u671f\u95f4\u8425\u4e1a\u5229\u6da6\u3001\u51c0\u4e8f\u635f\u6216\u4efb\u4f55\u5176\u4ed6\u4e1a\u7ee9\u8861\u91cf\u6307\u6807\u7684\u66ff\u4ee3\u54c1\uff0c\u6216\u4f5c\u4e3a\u5176\u7ecf\u8425\u4e1a\u7ee9\u7684\u8861\u91cf\u6307\u6807\u3002\u516c\u53f8\u9f13\u52b1\u6295\u8d44\u8005\u5ba1\u9605\u8be5\u5e74\u5ea6\/\u671f\u95f4\u7684Non-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\uff0c\u5e76\u5ba1\u9605\u6700\u76f4\u63a5\u53ef\u6bd4\u7684\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u4e0b\u8d22\u52a1\u6307\u6807\u7684\u8c03\u6574\u8fc7\u7a0b\u3002\u6b64\u5904\u6240\u5217\u5e74\u5ea6\/\u671f\u95f4\u7684Non-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\u53ef\u80fd\u65e0\u6cd5\u4e0e\u5176\u4ed6\u516c\u53f8\u63d0\u4f9b\u7684\u7c7b\u4f3c\u540d\u79f0\u7684\u8d22\u52a1\u6307\u6807\u76f8\u6bd4\u8f83\u3002\u5176\u4ed6\u516c\u53f8\u53ef\u80fd\u4f1a\u4ee5\u4e0d\u540c\u7684\u65b9\u5f0f\u8ba1\u7b97\u7c7b\u4f3c\u7684\u8d22\u52a1\u6307\u6807\uff0c\u4ece\u800c\u9650\u5236\u4e86\u5b83\u4eec\u4f5c\u4e3a\u516c\u53f8\u53ef\u6bd4\u6570\u636e\u7684\u6709\u7528\u6027\u3002\u5929\u6f14\u836f\u4e1a\u9f13\u52b1\u6295\u8d44\u8005\u548c\u5176\u4ed6\u4eba\u5168\u9762\u5ba1\u9605\u672c\u516c\u53f8\u7684\u8d22\u52a1\u4fe1\u606f\uff0c\u800c\u4e0d\u662f\u4ec5\u4ec5\u5173\u6ce8\u4e8e\u5355\u4e00\u7684\u8d22\u52a1\u6307\u6807\u3002<\/p>\n<p>\u672c\u5e74\u5ea6\/\u671f\u95f4\u8ba1\u7b97\u7684\u51c0\u5229\u6da6\u6307\u6807\u4e0bNon-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\uff0c\u4e0d\u5305\u62ec\u80a1\u6743\u6fc0\u52b1\u8d39\u7528\u3001\u53ef\u8f6c\u6362\u53ef\u8d4e\u56de\u4f18\u5148\u80a1\u589e\u52a0\u81f3\u53ef\u8d4e\u56de\u4ef7\u503c\u3002\u80a1\u6743\u6fc0\u52b1\u8d39\u7528\u662f\u5411\u5458\u5de5\u6388\u4e88\u80a1\u7968\u6fc0\u52b1\u6240\u4ea7\u751f\u7684\u975e\u73b0\u91d1\u8d39\u7528\u3002\u6211\u4eec\u8ba4\u4e3a\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u548c\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\u7684\u8c03\u6574\u4fe1\u606f\u80fd\u5bf9\u7ba1\u7406\u5c42\u548c\u6295\u8d44\u4eba\u5728\u8fdb\u884c\u516c\u53f8\u8fd0\u8425\u8868\u73b0\u7684\u540c\u671f\u6bd4\u8f83\u4ee5\u53ca\u540c\u4e1a\u6bd4\u8f83\u65f6\u6709\u6240\u52a9\u76ca\u3002\u5176\u539f\u56e0\u6709\uff1a\uff08i\uff09\u5728\u67d0\u7279\u5b9a\u671f\u95f4\u5185\u7684\u80a1\u6743\u6fc0\u52b1\u8d39\u7528\u4e0e\u516c\u53f8\u7684\u8fd0\u8425\u8868\u73b0\u672a\u5fc5\u76f4\u63a5\u76f8\u5173\uff1b\uff08ii\uff09\u56e0\u516c\u53f8\u6388\u4e88\u65b0\u7684\u80a1\u6743\u6fc0\u52b1\u8ba1\u5212\u7684\u65f6\u95f4\u5b89\u6392\uff0c\u80a1\u6743\u6fc0\u52b1\u8d39\u7528\u5728\u4e0d\u540c\u671f\u95f4\u5185\u53ef\u80fd\u4f1a\u53d1\u751f\u8f83\u5927\u53d8\u5316\uff1b\u4ee5\u53ca\uff0c\uff08iii\uff09\u5176\u4ed6\u516c\u53f8\u53ef\u80fd\u91c7\u53d6\u4e0d\u540c\u7684\u80a1\u6743\u6fc0\u52b1\u5f62\u5f0f\u6216\u8005\u4f7f\u7528\u4e0d\u540c\u7684\u4f30\u503c\u65b9\u6cd5\u3002<\/p>\n<p>\u8bf7\u53c2\u9605\u672c\u516c\u544a\u7ed3\u5c3e\u7684 \u201c\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff08GAAP\uff09\u548c\u975e\u7f8e\u56fd\u901a\u7528\u4f1a\u8ba1\u51c6\u5219\uff08Non-GAAP\uff09\u4e0b\u7684\u4e1a\u7ee9\u8c03\u8282\u8868\u201d\uff0c\u83b7\u53d6\u672c\u5e74\u5ea6\/\u671f\u95f4Non-GAAP\u51c0\u4e8f\u635f\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u51c0\u4e8f\u635f\u7684\u5b8c\u6574\u7684\u8c03\u6574\u8fc7\u7a0b\u3002<\/p>\n<p><b>\u5173\u4e8e\u5929\u6f14\u836f\u4e1a<\/b><\/p>\n<p>\u5929\u6f14\u836f\u4e1a\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aADAG\uff09\u662f\u5e73\u53f0\u9a71\u52a8\u5e76\u62e5\u6709\u81ea\u4e3b\u5e73\u53f0\u4ea7\u51fa\u7684\u4e34\u5e8a\u4ea7\u54c1\u5f00\u53d1\u9636\u6bb5\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u516c\u53f8\u81f4\u529b\u4e8e\u53d1\u73b0\u5e76\u5f00\u53d1\u4ee5\u539f\u521b\u6297\u4f53\u4e3a\u57fa\u77f3\u7684\u65b0\u578b\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u3002\u501f\u529b\u4e8e\u8ba1\u7b97\u751f\u7269\u5b66\u4e0e\u4eba\u5de5\u667a\u80fd\uff0c\u51ed\u501f\u5176\u5168\u7403\u9996\u521b\u7684\u4e09\u4f53\u5e73\u53f0\u6280\u672f\uff08\u65b0\u8868\u4f4d\u6297\u4f53NEObody&#x2122;\uff0c\u5b89\u5168\u6297\u4f53SAFEbody&#x2122;\u53ca\u5f3a\u529b\u6297\u4f53POWERbody&#x2122;\uff09\uff0c\u5929\u6f14\u836f\u4e1a\u5df2\u5efa\u7acb\u8d77\u805a\u7126\u4e8e\u65b0\u578b\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u72ec\u7279\u539f\u521b\u6297\u4f53\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u4ee5\u89e3\u51b3\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u3002\u5929\u6f14\u5df2\u548c\u591a\u4e2a\u5168\u7403\u77e5\u540d\u5408\u4f5c\u4f19\u4f34\u8fbe\u6210\u4e86\u6218\u7565\u5408\u4f5c\u5173\u7cfb\uff0c\u5e76\u4ee5\u5176\u539f\u521b\u524d\u6cbf\u79d1\u6280\u4e3a\u5408\u4f5c\u4f19\u4f34\u7684\u65b0\u836f\u7814\u53d1\u8d4b\u80fd\u3002<\/p>\n<p>\u5982\u9700\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee\uff1a<a target=\"_blank\" href=\"https:\/\/investor.adagene.com\/\" rel=\"nofollow noopener\">https:\/\/investor.adagene.com<\/a>\u3002<\/p>\n<p><b>\u5b89\u5168\u6e2f\u58f0\u660e<\/b><\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u5305\u542b\u524d\u77bb\u6027\u9648\u8ff0\uff0c\u5305\u62ec\u5173\u4e8e\u4e34\u5e8a\u6570\u636e\u5bf9\u60a3\u8005\u7684\u6f5c\u5728\u5f71\u54cd\u7684\u9648\u8ff0\uff0c\u4ee5\u53ca\u5929\u6f14\u836f\u4e1a\u7684\u63a8\u8fdb\u548c\u9884\u671f\u7684\u4e34\u5e8a\u524d\u6d3b\u52a8\u3001\u4e34\u5e8a\u5f00\u53d1\u3001\u76d1\u7ba1\u91cc\u7a0b\u7891\u4ee5\u53ca\u5176\u5019\u9009\u4ea7\u54c1\u7684\u5546\u4e1a\u5316\u3002\u7531\u4e8e\u5404\u79cd\u91cd\u8981\u56e0\u7d20\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u5929\u6f14\u836f\u4e1a\u8bc1\u660e\u5176\u5019\u9009\u836f\u7269\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u80fd\u529b\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4e0e\u524d\u77bb\u6027\u9648\u8ff0\u4e2d\u6240\u793a\u7684\u7ed3\u679c\u5b58\u5728\u91cd\u5927\u5dee\u5f02\uff1b\u5176\u5019\u9009\u836f\u7269\u7684\u4e34\u5e8a\u7ed3\u679c\uff0c\u53ef\u80fd\u4e0d\u652f\u6301\u8fdb\u4e00\u6b65\u5f00\u53d1\u6216\u76d1\u7ba1\u6279\u51c6\uff1b\u76f8\u5173\u76d1\u7ba1\u673a\u6784\u5c31\u5929\u6f14\u836f\u4e1a\u5019\u9009\u836f\u7269\u7684\u76d1\u7ba1\u6279\u51c6\u505a\u51fa\u51b3\u5b9a\u7684\u5185\u5bb9\u548c\u65f6\u95f4\uff1b\u5982\u679c\u83b7\u5f97\u6279\u51c6\uff0c\u5929\u6f14\u836f\u4e1a\u4e3a\u5176\u5019\u9009\u836f\u7269\u53d6\u5f97\u5546\u4e1a\u6210\u529f\u7684\u80fd\u529b\uff1b\u5929\u6f14\u836f\u4e1a\u4e3a\u5176\u6280\u672f\u548c\u836f\u7269\u83b7\u5f97\u548c\u7ef4\u6301\u77e5\u8bc6\u4ea7\u6743\u4fdd\u62a4\u7684\u80fd\u529b\uff1b\u5929\u6f14\u836f\u4e1a\u4f9d\u8d56\u7b2c\u4e09\u65b9\u8fdb\u884c\u836f\u7269\u5f00\u53d1\u3001\u5236\u9020\u548c\u5176\u4ed6\u670d\u52a1\uff1b\u5929\u6f14\u836f\u4e1a\u6709\u9650\u7684\u7ecf\u8425\u5386\u53f2\u4ee5\u53ca\u5929\u6f14\u836f\u4e1a\u83b7\u5f97\u989d\u5916\u8fd0\u8425\u8d44\u91d1\u4ee5\u53ca\u5b8c\u6210\u5176\u5019\u9009\u836f\u7269\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u7684\u80fd\u529b\uff1b\u5929\u6f14\u836f\u4e1a\u5728\u5176\u73b0\u6709\u6218\u7565\u4f19\u4f34\u5173\u7cfb\u6216\u5408\u4f5c\u4e4b\u5916\u7b7e\u8ba2\u989d\u5916\u5408\u4f5c\u534f\u8bae\u7684\u80fd\u529b\uff0c\u4ee5\u53ca&nbsp;COVID-19 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href=\"mailto:ir@adagene.com\" rel=\"nofollow noopener\">ir@adagene.com<\/a><\/u><\/p>\n<p>\u6295\u8d44\u8005\u8054\u7cfb\u4eba\uff1a<br \/><span class=\"xn-person\">Bruce Mackle<\/span><br \/>LifeSci Advisors<br \/>(01)646-889-1200<br \/><u><a target=\"_blank\" href=\"mailto:bmackle@lifesciadvisors.com\" rel=\"nofollow noopener\">bmackle@lifesciadvisors.com<\/a><\/u><\/p>\n<p>\u76f8\u5173\u94fe\u63a5 :<\/p>\n<p>https:\/\/investor.adagene.com<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8211; \u4e0e\u9ed8\u6c99\u4e1c\u8fbe\u6210\u4e09\u9879\u4e34\u5e8a\u5408\u4f5c\uff0c\u4ee5\u63a8\u8fdb\u4e09\u4e2a\u4e34\u5e8a\u6297\u80bf\u7624\u5019\u9009\u4ea7\u54c1\u4e0e\u5e15\u535a\u5229\u73e0\u5355\u6297\u7684\u5168\u7403\u8054\u5408\u8bd5\u9a8c &#8211; &#8211; 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