{"id":42222,"date":"2021-08-25T20:24:00","date_gmt":"2021-08-25T13:24:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021082520240042222"},"modified":"2021-08-26T21:37:56","modified_gmt":"2021-08-26T13:37:56","slug":"%e4%b8%89%e7%94%9f%e5%9b%bd%e5%81%a5%e5%85%ac%e5%b8%832021%e5%b9%b4%e5%8d%8a%e5%b9%b4%e6%8a%a5%ef%bc%9a%e6%a0%b8%e5%bf%83%e4%ba%a7%e5%93%81%e4%bf%9d%e6%8c%81%e9%be%99%e5%a4%b4%ef%bc%8c%e7%a0%94","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021082520240042222","title":{"rendered":"\u4e09\u751f\u56fd\u5065\u516c\u5e032021\u5e74\u534a\u5e74\u62a5\uff1a\u6838\u5fc3\u4ea7\u54c1\u4fdd\u6301\u9f99\u5934\uff0c\u7814\u53d1\u521b\u65b0\u5c61\u83b7\u7a81\u7834"},"content":{"rendered":"<p><p>\u4e0a\u6d77<span id=\"spanHghlt8197\">2021\u5e748\u670825\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; 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CSCO\u4e73\u817a\u764c\u8bca\u7597\u6307\u5357\u300b\uff0c\u6210\u4e3a\u665a\u671f\u4e73\u817a\u764c\u60a3\u8005\u5168\u7a0b\u6297HER2\u6cbb\u7597\u7684\u57fa\u7840\u836f\u7269\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u516c\u53f8\u4eca\u5e74\u8fd8\u9010\u6b65\u52a0\u5927\u4e86CD25\u4eba\u6e90\u5316\u5355\u6297\u5065\u5c3c\u54cc\u5728\u4e34\u5e8a\u5e94\u7528\u65b9\u9762\u7684\u5b66\u672f\u63a8\u5e7f\uff0c\u6ee1\u8db3\u76f8\u5173\u60a3\u8005\u7684\u4e34\u5e8a\u7528\u836f\u9700\u6c42\uff0c\u63a8\u8fdb\u5bf9\u5168\u56fd\u5404\u5730\u533b\u9662\u7684\u9500\u552e\u8986\u76d6\u30022021\u5e74\u4e0a\u534a\u5e74\uff0c\u65b0\u51a0\u75ab\u60c5\u5f71\u54cd\u51cf\u5f31\uff0c\u5168\u56fd\u80be\u79fb\u690d\u624b\u672f\u91cf\u9010\u6b65\u6062\u590d\uff0c\u5e26\u52a8\u5065\u5c3c\u54cc\u7684\u9500\u552e\u5927\u5e45\u589e\u957f\u3002\u62a5\u544a\u671f\u5185\uff0c\u5065\u5c3c\u54cc\u9500\u552e\u6536\u5165\u540c\u6bd4\u589e\u957f198.07%\u3002<\/p>\n<p><b>\u7814\u53d1\u7855\u679c\u7d2f\u7d2f \u84c4\u529b\u53d1\u5c55\u52a8\u80fd<\/b><\/p>\n<p>\u4e0a\u534a\u5e74\uff0c\u516c\u53f8\u7ee7\u7eed\u6df1\u8015\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u3001\u80bf\u7624\u3001\u773c\u79d1\u7b49\u70ed\u95e8\u75be\u75c5\u9886\u57df\uff0c\u4ee5\u4e34\u5e8a\u4ef7\u503c\u4e3a\u5bfc\u5411\uff0c\u6301\u7eed\u52a0\u5927\u521b\u65b0\u7814\u53d1\u6295\u5165\uff0c\u591a\u4e2a\u521b\u65b0\u4ea7\u54c1\u53d6\u5f97\u9636\u6bb5\u6027\u6210\u679c\uff0c\u7814\u53d1\u7ba1\u7ebf\u5f97\u5230\u8fdb\u4e00\u6b65\u5145\u5b9e\uff0c\u4e3a\u672a\u6765\u53d1\u5c55\u5960\u5b9a\u826f\u597d\u7684\u57fa\u7840\u3002<\/p>\n<ul type=\"disc\">\n<li>\u65b0\u83b7\u5f97\u4e34\u5e8a\u6279\u4ef63\u9879\uff1a<\/li>\n<\/ul>\n<p>\uff081\uff09&nbsp;&nbsp;&nbsp; \u6297HER2\u6297\u4f53\uff08612\uff09\u83b7NMPA\u6279\u51c6\u5f00\u5c55\u7528\u4e8e\u665a\u671f\u5b9e\u4f53\u7624\u6cbb\u7597\u7684\u4e34\u5e8a\u7814\u7a76<br \/>\uff082\uff09&nbsp;&nbsp;&nbsp; \u6297EGFR\u6297\u4f53\uff08602\uff09\u83b7NMPA\u6279\u51c6\u5f00\u5c55\u8054\u5408\u4f0a\u5c3c\u59a5\u5355\u6297\u53ca\u5316\u7597\u5728HER2 \u9633\u6027\u4e14KRAS\u3001NRAS \u548cBRAF \u91ce\u751f\u578b\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u7684Ib\/\u2161\u671f\u4e34\u5e8a\u7814\u7a76<br \/>\uff083\uff09&nbsp;&nbsp;&nbsp; \u6297HER2 x \u6297PD1\u53cc\u7279\u5f02\u6297\u4f53\uff08705\uff09\u83b7FDA\u6279\u51c6\u5f00\u5c55\u6cbb\u7597\u665a\u671f\u6216\u8f6c\u79fb\u6027 HER2 \u8868\u8fbe\u9633\u6027\u7684\u5b9e\u4f53\u7624\u7684\u4e34\u5e8a\u7814\u7a76<\/p>\n<ul type=\"disc\">\n<li>\u65b0\u9012\u4ea4IND\u7533\u8bf74\u9879\uff1a<\/li>\n<\/ul>\n<p>\uff081\uff09&nbsp;&nbsp;&nbsp; \u91cd\u7ec4\u4eba\u6e90\u5316\u6297IL-1\u03b2\u6297\u4f53\uff08613\uff09\u6cbb\u7597\u5468\u671f\u6027\u53d1\u70ed\u7efc\u5408\u5f81\uff08NMPA\uff09<br \/>\uff082\uff09&nbsp;&nbsp;&nbsp; \u91cd\u7ec4\u4eba\u6e90\u5316\u6297IL-1\u03b2\u6297\u4f53\uff08613\uff09\u6cbb\u7597\u5168\u8eab\u6027\u5e7c\u5e74\u7279\u53d1\u6027\u5173\u8282\u708e\uff08NMPA\uff09<br \/>\uff083\uff09&nbsp;&nbsp;&nbsp; \u91cd\u7ec4\u4eba\u6e90\u5316\u53cc\u7279\u5f02\u6297\u4f53\uff08705\uff09\u6cbb\u7597\u5b9e\u4f53\u7624\uff08NMPA\uff09<br \/>\uff084\uff09&nbsp;&nbsp;&nbsp; \u4f0a\u5c3c\u59a5\u5355\u6297\u8054\u5408\u6297CD47\u878d\u5408\u86cb\u767dIMM01 \u6cbb\u7597HER2\u9633\u6027\u5b9e\u4f53\u7624\uff08NMPA\uff09<\/p>\n<ul type=\"disc\">\n<li>\u65b0\u589ePre-IND \u7533\u8bf71\u9879\uff1a<\/li>\n<\/ul>\n<p>\uff081\uff09&nbsp;&nbsp;&nbsp; \u91cd\u7ec4\u4eba\u6e90\u5316\u53cc\u7279\u5f02\u6297\u4f53\uff08706\uff09\u6cbb\u7597\u5b9e\u4f53\u7624\uff08NMPA\uff09<\/p>\n<ul type=\"disc\">\n<li>\u65b0\u589e\u6297\u4f53\u7acb\u98793\u9879\uff1a<\/li>\n<\/ul>\n<p>\uff081\uff09&nbsp;&nbsp;&nbsp; \u91cd\u7ec4\u4eba\u6e90\u5316\u6297LAG-3\u5355\u514b\u9686\u6297\u4f53\uff08619\uff09<br \/>\uff082\uff09&nbsp;&nbsp;&nbsp; \u91cd\u7ec4\u4eba\u6e90\u5316\u6297 IL-33 \u6297\u4f53\uff08621\uff09<br \/>\uff083\uff09&nbsp;&nbsp;&nbsp; \u91cd\u7ec4\u4eba\u6e90\u5316\u6297CD73\u6297\u4f53\uff08622\uff09<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder1989\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/1601703\/image.html\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/image-405.jpg\" title=\"\u4e09\u751f\u56fd\u5065\u7814\u53d1\u7ba1\u7ebf\uff08\u622a\u6b622021\u5e746\u670830\u65e5\uff09\" alt=\"\u4e09\u751f\u56fd\u5065\u7814\u53d1\u7ba1\u7ebf\uff08\u622a\u6b622021\u5e746\u670830\u65e5\uff09\" \/><\/a><br \/><span>\u4e09\u751f\u56fd\u5065\u7814\u53d1\u7ba1\u7ebf\uff08\u622a\u6b622021\u5e746\u670830\u65e5\uff09<\/span><\/p>\n<\/p><\/div>\n<p>\u7ba1\u7ebf\u5185\u5176\u4ed6\u4ea7\u54c1\u7684\u7814\u53d1\u8fdb\u5c55\u4e5f\u6709\u5e8f\u63a8\u8fdb\u3002<\/p>\n<ul type=\"disc\">\n<li>\u91cd\u7ec4\u4eba\u9f20\u5d4c\u5408\u6297CD20\u5355\u514b\u9686\u6297\u4f53\u6ce8\u5c04\u6db2\uff08304R\uff09\u662f\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684\u9488\u5bf9\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u6cbb\u7597\u7684\u6297\u4f53\u836f\u7269\uff0c2021\u5e74\u81f3\u4eca\u5df2\u5b8c\u6210 III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6838\u67e5 <\/li>\n<li>\u91cd\u7ec4\u4ebaII\u578b\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u53d7\u4f53-\u6297\u4f53\u878d\u5408\u86cb\u767d\u6ce8\u5c04\u6db2\uff08301S\uff09\u662f\u76ca\u8d5b\u666e\u7684\u65b0\u5242\u578b\uff0c\u4e5f\u662f\u76f8\u5173\u836f\u54c1\u56fd\u5185\u9996\u4e2a\u9884\u5145\u5f0f\u5242\u578b\uff0c2021\u5e74\u81f3\u4eca\u5df2\u91cd\u65b0\u9012\u4ea4 NDA\u7533\u8bf7 <\/li>\n<li>\u91cd\u7ec4\u6297VEGF\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\u6ce8\u5c04\u6db2\uff08601A\uff092021\u5e74\u81f3\u4eca\u5df2\u5b8c\u6210AMD\u548cDME I\/Ib\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff1bBRVO II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5165\u7ec4\u5b8c\u6210\uff1bCRVO II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u75c5\u4eba\u5165\u7ec4\u987a\u5229\uff1bCNV II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5f00\u59cb\u5165\u7ec4 <\/li>\n<li>\u91cd\u7ec4\u6297EGFR\u4eba\u9f20\u5d4c\u5408\u5355\u514b\u9686\u6297\u4f53\u6ce8\u5c04\u6db2\uff08602\uff09\u662f\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684\u9488\u5bf9\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u6cbb\u7597\u7684\u6297\u4f53\u836f\u7269\uff0c2021\u5e74\u81f3\u4ecaII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5165\u7ec4\u7387\u5df2\u8fbe50% <\/li>\n<li>\u6297IL-17A\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\uff08608\uff09\u662f\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684\u6cbb\u7597\u6591\u5757\u72b6\u94f6\u5c51\u75c5\u836f\u7269\uff0c2021\u5e74\u81f3\u4eca\u5df2\u5b8c\u6210I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0cII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5f00\u59cb\u5165\u7ec4 <\/li>\n<li>\u6297PD-1\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\u6ce8\u5c04\u6db2\uff08609A\uff092021\u5e74\u81f3\u4eca\u5df2\u5b8c\u6210\u5728\u4e2d\u56fd\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e76\u9012\u4ea4\u8054\u5408\u7528\u836f\u6cbb\u7597\u591a\u79cd\u5b9e\u4f53\u7624II\/III\u671f\u4e34\u5e8aIND <\/li>\n<li>\u6297IL-5\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\u6ce8\u5c04\u6db2\uff08610\uff09\u9488\u5bf918\u5c81\u53ca\u4ee5\u4e0a\u91cd\u5ea6\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u6027\u54ee\u5598\u7ef4\u6301\u6cbb\u7597\u7684\u9644\u52a0\u6cbb\u7597\uff0c2021\u5e74\u81f3\u4eca\u5df2\u5b8c\u6210Ia\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u542f\u52a8Ib+II\u671f\u4e34\u5e8a\u8bd5\u9a8c <\/li>\n<li>\u6297IL-4R\u03b1\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\u836f\u7269\uff08611\uff09\u9488\u5bf9\u4e2d\u91cd\u5ea6\u7279\u5e94\u6027\u76ae\u708e\u53ca\u54ee\u5598\u7684\u6cbb\u7597\uff0c2021\u5e74\u81f3\u4eca\u5df2\u5728\u7f8e\u56fd\u5b8c\u6210I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6b63\u5728\u8fdb\u884c\u6570\u636e\u9501\u5e93\u5206\u6790\uff0c\u5e76\u5728\u4e2d\u56fd\u542f\u52a8Ib\/II\u671f\u8bd5\u9a8c\u5165\u7ec4<\/li>\n<\/ul>\n<p><span 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