{"id":41922,"date":"2021-08-24T17:28:00","date_gmt":"2021-08-24T10:28:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021082417280041922"},"modified":"2021-08-24T21:39:03","modified_gmt":"2021-08-24T13:39:03","slug":"%e9%87%91%e6%96%af%e7%91%9e%e7%94%9f%e7%89%a9%e7%a7%91%e6%8a%80%e5%8f%91%e5%b8%832021%e5%b9%b4%e5%ba%a6%e4%b8%ad%e6%9c%9f%e4%b8%9a%e7%bb%a9","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021082417280041922","title":{"rendered":"\u91d1\u65af\u745e\u751f\u7269\u79d1\u6280\u53d1\u5e032021\u5e74\u5ea6\u4e2d\u671f\u4e1a\u7ee9"},"content":{"rendered":"

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\u63d0\u524d\u5e03\u5c40\uff0c\u524d\u77bb\u6027\u951a\u5b9a<\/b>GCT<\/b>\u4e1a\u52a1\u5168\u4ea7\u4e1a\u94fe<\/b><\/p>\n

\u4f5c\u4e3a\u5168\u7403\u5e02\u573a\u5360\u6709\u7387\u7b2c\u4e00\u7684\u57fa\u56e0\u5408\u6210\u4f9b\u5e94\u5546\uff0c\u91d1\u65af\u745e\u5728\u57fa\u56e0\u5408\u6210\u9886\u57df\u6df1\u8015\u5341\u4f59\u5e74\uff0c\u6280\u672f\u4f18\u52bf\u660e\u663e\uff0c\u4e1a\u52a1\u7a33\u5b9a\u589e\u957f\uff0c\u8fd9\u662f\u516c\u53f8\u65e2\u5f80\u6536\u5165\u6765\u6e90\u7684\u4e3b\u8981\u6784\u6210\uff0c\u4e5f\u662f\u91d1\u65af\u745e\u5e03\u5c40\u7ec6\u80de\u4e0e\u57fa\u56e0\u6cbb\u7597\uff08GCT\uff09\u4e1a\u52a1\u7684\u6280\u672f\u57fa\u77f3\u3002\u76ee\u524d\uff0c\u91d1\u65af\u745e\u751f\u547d\u79d1\u5b66\u670d\u52a1\u53ca\u4ea7\u54c1\u4e1a\u52a1\u3001\u751f\u7269\u836fCDMO\u4e1a\u52a1\u3001\u7ec6\u80de\u6cbb\u7597\u4e1a\u52a1\u5747\u5728GCT\u4e0a\u5f3a\u52bf\u53d1\u529b\uff0c\u91d1\u65af\u745e\u6df1\u8015GCT\u884c\u4e1a\u7684\u5168\u4ea7\u4e1a\u94fe\u5df2\u642d\u5efa\u5b8c\u6210\u3002<\/p>\n

\u9664\u57fa\u56e0\u5408\u6210\u4e1a\u52a1\uff0c\u751f\u547d\u79d1\u5b66\u670d\u52a1\u53ca\u4ea7\u54c1\u4e1a\u52a1\u677f\u5757<\/b>\u4e5f\u5728GCT\u9886\u57df\u52a0\u901f\u5e03\u5c40\uff0c\u9488\u5bf9\u6027\u5f00\u53d1\u9ad8\u4ef7\u503c\u7684\u5173\u952e\u8bd5\u5242\u53ca\u4eea\u5668\u4ea7\u54c1\uff0c\u63a8\u52a8\u4e1a\u52a1\u8fc5\u901f\u53d1\u5c55\uff0c\u5e76\u52a9\u529b\u6574\u4e2a\u884c\u4e1a\u89e3\u51b3\u5236\u5907\u6210\u672c\u8f83\u9ad8\u7684\u95ee\u9898\u3002\u8fd9\u4e5f\u662f\u91d1\u65af\u745e\u5e03\u5c40GCT\u4e1a\u52a1\u5168\u4ea7\u4e1a\u94fe\u7684\u91cd\u8981\u4e00\u73af\u3002<\/p>\n

\u501f\u52a9\u81ea\u8eab\u5728\u751f\u547d\u79d1\u5b66\u9886\u57df\u7684\u6df1\u539a\u79ef\u7d2f\u800c\u83b7\u5f97\u7684\u654f\u9510\u55c5\u89c9\uff0c\u91d1\u65af\u745e\u5728\u56fd\u5185\u7387\u5148\u5e03\u5c40\u57fa\u56e0\u548c\u7ec6\u80de\u6cbb\u7597\u7684<\/b>CDMO<\/b>\u4e1a\u52a1<\/b>\uff0c\u53c8\u4e00\u6b21\u6293\u4f4f\u4e86\u884c\u4e1a\u673a\u9047\uff0c\u73b0\u5df2\u6210\u4e3a\u56fd\u5185\u9996\u5c48\u4e00\u6307\u7684\u8d28\u7c92\u4f9b\u5e94\u5546\uff0c\u53ef\u4e3a\u5ba2\u6237\u63d0\u4f9b\u5305\u62ec\u73b0\u8d27\u8d28\u7c92\u3001\u975e\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76\u7ea7\u522b\u7684\u8d28\u7c92\u3001\u8d28\u7c92\u4e34\u5e8a\u7533\u62a5\u548c\u8d28\u7c92\u4e34\u5e8a\u7ea7GMP\u751f\u4ea7\u7b49\u4ea7\u54c1\u53ca\u670d\u52a1\u3002<\/p>\n

\u91d1\u65af\u745e\u84ec\u52c3\u751f\u7269\u62e5\u6709\u56fd\u5185\u552f\u4e00\u7684\u53ef\u4ee5\u4e3amRNA\u75ab\u82d7\u63d0\u4f9b\u4f53\u5916\u8f6c\u5f55\u7684\u7ebf\u6027\u5316\u8d28\u7c92GMP\u751f\u4ea7\u5e73\u53f0\uff1b\u5e76\u5f00\u53d1\u4e86\u4e2d\u56fd\u7b2c\u4e00\u4e2a\u81ea\u4e3b\u7814\u53d1\u7684\u6162\u75c5\u6bd2\u60ac\u6d6e\u751f\u4ea7\u7ec6\u80de\u7cfb\uff0c\u75c5\u6bd2\u4ea7\u91cf\u4e0e\u76ee\u524d\u5e02\u573a\u4e0a\u4f7f\u7528\u6700\u5e7f\u6cdb\u7684\u7ec6\u80de\u7cfb\u76f8\u5f53\u751a\u81f3\u66f4\u4f18\uff1b\u540c\u65f6\u5efa\u7acb\u4e86AAV\u60ac\u6d6e\u751f\u4ea7\u5de5\u827a\u5e73\u53f0\uff0c\u5373\u5c06\u63a8\u51fa\u81ea\u4e3b\u7814\u53d1\u7684AAV\u60ac\u6d6e\u751f\u4ea7\u7ec6\u80de\u7cfb\u3002 <\/p>\n

\u6b64\u5916\uff0c\u91d1\u65af\u745e\u4e8e2014\u5e74\u5e03\u5c40\u7684\u4e13\u6ce8\u7ec6\u80de\u7597\u6cd5\u7684\u5b50\u516c\u53f8\u4f20\u5947\u751f\u7269<\/b>\uff0c\u4f5c\u4e3a\u91d1\u65af\u745eGCT\u5168\u4ea7\u4e1a\u94fe\u7684\u4ea7\u54c1\u7aef\uff0c\u901a\u8fc7\u591a\u5e74\u79ef\u7d2f\uff0c\u73b0\u5df2\u6210\u4e3a\u56fd\u5185GCT\u5e94\u7528\u9886\u57df\u7684\u5148\u884c\u8005\u3002\u9664\u73b0\u6709\u6838\u5fc3\u4ea7\u54c1cilta-cel\u5916\uff0c\u8fd8\u6709\u591a\u6b3e\u5728\u7814CAR-T\u7597\u6cd5\uff0c\u5df2\u5728\u8840\u6db2\u80bf\u7624\u3001\u5b9e\u4f53\u80bf\u7624\u53ca\u4f20\u67d3\u6027\u75be\u75c5\u4e0a\u6709\u8d85\u8fc710\u4e2a\u4e0d\u540c\u7684\u7ba1\u7ebf\uff0c\u5e76\u5e03\u5c40\u4e86\u81ea\u4f53CAR-T\u3001\u5f02\u4f53CAR-T\u3001TCR\u7b49\u591a\u4e2a\u7814\u53d1\u5e73\u53f0\u3002<\/p>\n

\u6b64\u5916\uff0c\u4f20\u5947\u751f\u7269\u5728\u7f8e\u56fd\u7684\u65b0\u6cfd\u897f\u3001\u6b27\u6d32\u7684\u6bd4\u5229\u65f6\u3001\u4e2d\u56fd\u7684\u5357\u4eac\u90fd\u5df2\u9010\u6b65\u5efa\u7acb\u751f\u4ea7\u8bbe\u65bd\uff0c\u4e3a\u5373\u5c06\u5230\u6765\u7684\u5168\u7403\u5546\u4e1a\u5316\u505a\u597d\u4ea7\u80fd\u4f9b\u5e94\u7684\u5e03\u5c40\u3002<\/p>\n

\u6301\u7eed\u6295\u5165\uff0c\u4e3a\u672a\u6765\u53d1\u5c55\u79ef\u84c4\u529b\u91cf<\/b><\/p>\n

2021\u4e0a\u534a\u5e74\uff0c\u91d1\u65af\u745e\u7ee7\u7eed\u5728\u521b\u65b0\u7814\u53d1\u4e0a\u6301\u7eed\u6295\u5165\uff0c\u4e3a\u672a\u6765\u589e\u957f\u5960\u5b9a\u57fa\u7840\u3002<\/p>\n

2021\u4e0a\u534a\u5e74\u7814\u53d1\u8d39\u7528\u4e3a1.75\u4ebf\u7f8e\u5143\uff0c\u540c\u6bd4\u589e\u957f51.6%\u3002\u5176\u4e2d\uff0c\u5728\u975e\u7ec6\u80de\u6cbb\u7597\u4e1a\u52a1\u5355\u5143\u7684\u7814\u53d1\u8d39\u7528\u7ea6\u4e3a\u6536\u5165\u768410\uff05\u5de6\u53f3\uff1b\u7ec6\u80de\u6cbb\u7597\u4e1a\u52a1\u7684\u7814\u53d1\u8d39\u7528\u4e3a1.55\u4ebf\u7f8e\u5143\uff0c\u540c\u6bd4\u589e\u957f52.1\uff05\uff0c\u5927\u90e8\u5206\u7528\u4e8ecilta-cel\u9879\u76ee\u3002\u8d44\u672c\u652f\u51fa\u4e3a7140\u4e07\u7f8e\u5143\uff0c\u4e3b\u8981\u7528\u4e8eGMP\u7684\u8bbe\u65bd\u548c\u5176\u4ed6\u57fa\u7840\u8bbe\u65bd\u6269\u5efa\u7b49\u3002<\/p>\n

\u8fd9\u4e9b\u6218\u7565\u6027\u6295\u8d44\u80cc\u540e\u7684\u6df1\u5c42\u903b\u8f91\u6e90\u81ea\u5e02\u573a\u53ca\u884c\u4e1a\u7684\u53d8\u5316 — GCT\u5df2\u7ecf\u6210\u4e3a\u4e0b\u4e00\u6b21\u4ea7\u4e1a\u9769\u547d\u7684\u91cd\u70b9\u9886\u57df\uff0c\u6f5c\u529b\u5de8\u5927\uff0c\u800c\u4e0e\u6b64\u76f8\u5173\u7684CRO\/CDMO\u5e73\u53f0\u5219\u62e5\u6709\u5e7f\u9614\u7684\u5e02\u573a\u7a7a\u95f4\u3002\u56e0\u6b64\uff0c\u91d1\u65af\u745e\u5728\u672a\u67652-3\u5e74\u7684\u6295\u5165\u5c06\u4e3b\u8981\u96c6\u4e2d\u5728\u751f\u547d\u79d1\u5b66\u4e1a\u52a1\u548c\u751f\u7269\u836fCDMO\u4e1a\u52a1\u4e24\u4e2a\u677f\u5757\u3002<\/p>\n

\u751f\u547d\u79d1\u5b66\u4e1a\u52a1\u5c06\u4e3b\u8981\u5e03\u5c40\u4e24\u4e2a\u5927\u65b9\u5411\uff0c\u4e00\u662fGCT\u6240\u9700\u7684\u670d\u52a1\uff0c\u5305\u62ecssDNA\u3001sgRNA\u7b49\uff1b\u4e8c\u662f\u6c72\u53d6\u4f20\u5947\u751f\u7269\u53d1\u5c55\u6240\u79ef\u7d2f\u7684\u7ecf\u9a8c\uff0c\u63a8\u51fa\u4e00\u7cfb\u5217\u9488\u5bf9\u7ec6\u80de\u6cbb\u7597\u884c\u4e1a\u75db\u70b9\u7684\u8bd5\u5242\u53ca\u4eea\u5668\uff0c\u5e76\u901a\u8fc7\u81ea\u52a8\u5316\u4ea7\u4e1a\u7ebf\u5347\u7ea7\uff0c\u63d0\u4f9b\u5de5\u4e1a\u5316\u7684\u670d\u52a1\u8d28\u91cf\u6807\u51c6\u7b49\u624b\u6bb5\uff0c\u63d0\u5347\u5e02\u573a\u5360\u6709\u7387\u53ca\u76c8\u5229\u80fd\u529b\u3002<\/p>\n

\u5728\u751f\u7269\u836fCDMO\u7684\u6218\u7565\u6295\u5165\u65b9\u9762\uff0c\u91d1\u65af\u745e\u5c06\u628a\u4ea7\u80fd\u548c\u57fa\u7840\u8bbe\u65bd\u5efa\u8bbe\u4f5c\u4e3a\u6295\u5165\u7684\u91cd\u70b9\u65b9\u9762\u3002\u91d1\u65af\u745e\u84ec\u52c3\u751f\u7269\u5df2\u7ecf\u62e5\u6709\u4e86\u72ec\u7acb\u7684\u878d\u8d44\u5e73\u53f0\uff0c\u8fd9\u5bf9\u4e8e\u4e00\u4e2a\u91cd\u8d44\u4ea7\u7684\u4e1a\u52a1\u6765\u8bf4\uff0c\u5177\u6709\u4e3e\u8db3\u8f7b\u91cd\u7684\u6218\u7565\u610f\u4e49\u3002<\/p>\n

\u672a\u6765\uff0c\u91d1\u65af\u745e\u4ea7\u80fd\u5efa\u8bbe\u4e0a\u7684\u6295\u5165\u5c06\u9996\u5148\u4e13\u6ce8\u5728GCT\u4e1a\u52a1\u7684CDMO\u9886\u57df\uff0c\u9884\u8ba1\u4eca\u5e74\u5e74\u5185\u5728\u9547\u6c5f\u5efa\u6210\u7b2c\u4e8c\u4e2aGMP\u7ea7\u522b\u7684\u8d28\u7c92\u5de5\u5382\u5e76\u6b63\u5f0f\u6295\u4ea7\uff0c\u5c4a\u65f6\uff0c\u4ea7\u80fd\u5c06\u8f83\u76ee\u524d\u589e\u52a0\u4e00\u500d\u4ee5\u4e0a\u3002\u5728\u6297\u4f53\u836fCDMO\u9886\u57df\uff0c\u5c06\u5bf9\u6297\u4f53\u53d1\u73b0\u548c\u5f00\u53d1\u4ee5\u53caCMC\u7684\u4ea7\u80fd\u8fdb\u884c\u6269\u5efa\uff0c\u8fdb\u4e00\u6b65\u63d0\u5347\u5728\u4e0a\u6e38\u4e1a\u52a1\u7684\u901a\u91cf\uff1b\u6b63\u5728\u5efa\u8bbe\u4e2d\u7684\u751f\u7269\u5236\u5242\u7f50\u88c5\u751f\u4ea7\u7ebf\uff0c\u9884\u8ba1\u57282022\u5e74\u4e0b\u534a\u5e74\u4e5f\u4f1a\u6b63\u5f0f\u6295\u4ea7\uff0c\u4ee5\u66f4\u5168\u9762\u7684\u6ee1\u8db3\u5ba2\u6237\u9879\u76ee\u9700\u6c42\u3002\u540c\u65f6\uff0c\u5728\u5546\u4e1a\u5316\u751f\u4ea7\u65b9\u9762\uff0c\u5728\u9547\u6c5f\u89c4\u5212\u7684\u603b\u8ba112000L\u4ea7\u80fd\u7684\u751f\u4ea7\u4e2d\u5fc3\u4e5f\u5728\u5efa\u8bbe\u4e4b\u4e2d\u3002<\/p>\n

\u91d1\u65af\u745e\u8f6e\u503c\u9996\u5e2d\u6267\u884c\u5b98\u67f3\u632f\u5b87\u535a\u58eb\u8868\u793a\uff0c\u201c\u91d1\u65af\u745e2021\u4e0a\u534a\u5e74\u7ee7\u7eed\u4fdd\u6301\u9ad8\u901f\u589e\u957f\uff0c\u96c6\u56e2\u6218\u7565\u5e03\u5c40\u7684GCT\u76f8\u5173\u4e1a\u52a1\uff0c\u4e5f\u4f53\u73b0\u51fa\u4e86\u5feb\u901f\u53d1\u5c55\u7684\u52bf\u5934\u3002\u8fd9\u79cd\u524d\u77bb\u6027\u5e03\u5c40\u53d6\u5f97\u7684\u6210\u5c31\uff0c\u79bb\u4e0d\u5f00\u91d1\u65af\u745e\u4eba\u957f\u671f\u5bf9\u751f\u547d\u79d1\u5b66\u7684\u6280\u672f\u79ef\u6dc0\u53ca\u884c\u4e1a\u6d1e\u5bdf\u3002\u672a\u6765\uff0c\u91d1\u65af\u745e\u5c06\u4e0d\u65ad\u592f\u5b9e\u5185\u529f\uff0c\u63a8\u52a8\u884c\u4e1a\u53d1\u5c55\uff0c\u4ee5\u8df5\u884c\u6211\u4eec\u2018\u7528\u751f\u7269\u6280\u672f\u4f7f\u4eba\u548c\u81ea\u7136\u66f4\u5065\u5eb7\u2019\u7684\u4f01\u4e1a\u4f7f\u547d\u3002\u201d<\/p>\n

\u76f8\u5173\u94fe\u63a5 :<\/p>\n

https:\/\/www.genscript.com.cn\/<\/p>\n","protected":false},"excerpt":{"rendered":"

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