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type=\"disc\">\n<li><b>\u6297\u764c\u589e\u654f\u5242<br \/><\/b>JP001\u53ef\u5f15\u53d1\u81ea\u566c\uff0c\u6291\u5236\u80bf\u7624\u7ec6\u80de\u589e\u6b96\uff0c\u4fc3\u8fdb\u7ec6\u80de\u51cb\u4ea1\uff0c\u589e\u52a0\u653e\u5316\u7597\u654f\u611f\u6027\u3002 <\/li>\n<li><b>\u6781\u5927\u7684\u5f00\u53d1\u4ef7\u503c<br \/><\/b>JP001\u5bf9GBM\u3001\u8089\u7624\u3001\u96be\u6cbb\u6027\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u3001\u6cbb\u7597\u5931\u8d25\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3001\u6dcb\u5df4\u7ba1\u808c\u7624\u3001\u8180\u80f1\u764c\u3001\u80be\u7ec6\u80de\u764c\u7b49\u5747\u6709\u7597\u6548\u3002\u5b9e\u9a8c\u53d1\u73b0JP001\u4e0e\u516c\u53f8\u5728\u7814\u65b0\u836f\u514b\u6765\u592b\u5b9a\u5728\u4e59\u809d\u75c5\u6bd2\u8f6c\u67d3\u7684\u809d\u764c\u7ec6\u80de\u7cfb\u4e2d\u6709\u534f\u540c\u6740\u4f24\u4f5c\u7528\uff0c\u5355\u836f\u6216\u8054\u5408\u7528\u836f\u5bf9\u80bf\u7624\u7ec6\u80de\u4ee3\u8c22\u7684\u5f71\u54cd\u6b63\u5728\u5f00\u5c55\u7814\u7a76\u3002 <\/li>\n<li><b>GBM<\/b><b>\u6cbb\u7597\u6548\u679c\u660e\u663e\u4f18\u4e8e\u6807\u51c6\u6cbb\u7597<br \/><\/b>\u76ee\u524d\u65b0\u8bca\u65adGBM\u7684\u6cbb\u7597\u57fa\u672c\u4ee5\u624b\u672f\u6cbb\u7597\u7ed3\u5408\u653e\u5316\u7597\u4f5c\u4e3a\u6807\u51c6\u6cbb\u7597\uff0c\u6cbb\u7597\u6548\u679c\u4e0d\u4f73\u3002JP001\u8054\u5408\u6807\u51c6\u6cbb\u7597\u7597\u6548\u660e\u663e\u4f18\u4e8e\u6807\u51c6\u6cbb\u7597\uff0c\u4e14\u5176\u6cbb\u7597\u6548\u679c\u4e0e\u7279\u5b9a\u7684Bio-marker\u9ad8\u5ea6\u5173\u8054\u3002<\/li>\n<\/ul>\n<p><b><u>JP001<\/u><\/b><\/p>\n<p><b><u>II\/III<\/u><\/b><b><u>\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5c0f\u7ed3\uff08\u5df2\u5165\u7ec4\u7684\u60a3\u8005\uff09<\/u><\/b><\/p>\n<p>\u4e2d\u56fd\u53f0\u6e7e\u6b63\u5728\u8fdb\u884c\u7684<u>\u65b0\u8bca\u65ad\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u653e\u5c04\u6cbb\u7597\u52a0\u7528\u66ff\u83ab\u5511\u80fa\u52a0\u7528\u6216\u4e0d\u52a0\u7528\u6cbb\u7597\u4e4b\u968f\u673a<\/u><u>II\/III<\/u><u>\u671f\u8bd5\u9a8c<\/u>\uff0c\u8be5\u8bd5\u9a8c\u8ba1\u5212\u5c06\u4ece\u7f8e\u56fd\uff0c\u4e2d\u56fd\u5927\u9646\u53ca<span id=\"spanHghlt8b75\">\u4e2d\u56fd<\/span>\u53f0\u6e7e\u4e09\u5730\u56fd\u9645\u591a\u4e2d\u5fc3\u5171\u5165370\u4f4d\u60a3\u8005\uff1b\u73b0\u5df2\u67096\u4f8b\u60a3\u8005\u968f\u673a\u7eb3\u5165\u8bd5\u9a8c\u7ec4\uff08\u6807\u51c6\u6cbb\u7597TMZ\/RTZ\u6cbb\u7597\u8054\u5408JP001\uff09\u3002<\/p>\n<p>\u8bd5\u9a8c\u7ec4\u76846\u4f8b\u60a3\u8005\u4e2d4\u4f4d\u4e3a\u5973\u6027\uff0c2\u4f4d\u4e3a\u7537\u6027\uff0c\u5e74\u9f84\u754c\u4e4e41\u523058\u5c81\uff0c\u4e2d\u4f4d\u6cbb\u7597\u671f\u4e3a14\u4e2a\u6708\u7684JP001\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u8010\u53d7\u6027\u597d\uff0c\u65e03\u5ea6\u6bd2\u6027\u3002<\/p>\n<p>\u636e\u89c2\u5bdf\uff0c<b>\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08<\/b><b>PFS<\/b><b>\uff09\u8d85\u8fc7<\/b><b>14<\/b><b>\u4e2a\u6708\uff08\u5176\u4e2d<\/b><b>006<\/b><b>\u53f7\u60a3\u8005<\/b><b>PFS<\/b><b>\uff1e<\/b><b>21<\/b><b>\u4e2a\u6708\uff09<\/b>\uff1b\u622a\u6b62\u76ee\u524d\u90e8\u5206\u60a3\u8005\u4ecd\u5b58\u6d3b<b>\uff0c<\/b><b>\u603b\u751f\u5b58\u671f\uff08<\/b><b>OS<\/b><b>\uff09\u6700\u957f\u5df2\u8d85<\/b><b>2<\/b><b>9<\/b><b>\u4e2a\u6708\u3002<\/b><b>PFS<\/b><b>\u548c<\/b><b>OS<\/b><b>\u5747\u8fdc\u8fdc\u9ad8\u4e8e\u73b0\u6709\u6807\u51c6\u6cbb\u7597\uff0c\u4e14\u4e0e\u7279\u5b9a\u7684<\/b><b>Bio-marker<\/b><b>\u76f8\u5173\u6027\u8fbe\u5230<\/b><b>100%<\/b><b>\u3002<\/b><\/p>\n<p>\u56de\u5e94\u6b64\u6b21\u91cc\u7a0b\u7891\uff0c<b>\u5468\u535a\u58eb<\/b>\u8868\u793a\uff1a<\/p>\n<p><span>\u201c<\/span><i>JP001<\/i><i>\u5728\u4e2d\u56fd\u53f0\u6e7e\u5df2\u5f00\u5c55\u4e34\u5e8a<\/i><i>II\/III<\/i><i>\u671f\u8bd5\u9a8c\uff0c<\/i><i>\u521d\u6b65<\/i><i>\u4e34\u5e8a\u8bd5\u9a8c<\/i><i>\u7ed3\u679c<\/i><i>\u663e\u793a\uff0c\u60a3\u8005\u7684\u8010\u53d7\u6027\u826f\u597d\uff0c\u6cbb\u7597\u7ec4<\/i><i>6<\/i><i>\u4f8b\u60a3\u8005\u4e2d<\/i><i>4<\/i><i>\u4f8b\u7597\u6548\u663e\u7740\uff0c\u5176\u4e2d<\/i><i>2<\/i><i>\u4f8b<\/i><i>PFS&gt;20<\/i><i>\u4e2a\u6708\u3001<\/i><i>OS<\/i><i>\u6700\u957f\u5df2\u8d85<\/i><i>29<\/i><i>\u4e2a\u6708\uff0c\u81f3\u4eca\u4ecd\u5b58\u6d3b\u4e14\u65e0\u590d\u53d1\u8ff9\u50cf\u3002<\/i><\/p>\n<p><i>\u66f4\u4ee4\u4eba\u5174\u594b\u7684\u662f\u7597\u6548\u663e\u75c5\u4f8b\u4e0e\u7279\u5b9a\u7684\u751f\u7269\u6807\u5fd7\u7269\uff08<\/i><i>Bio-marker<\/i><i>\uff09\u7684\u9ad8\u5ea6\u5173\u8054\u6027\u5bf9<\/i><i>JP001<\/i><i>\u7684\u7cbe\u51c6\u6cbb\u7597\uff0c\u964d\u4f4e\u4e34\u5e8a\u8bd5\u9a8c\u6210\u672c\uff0c\u52a0\u901f\u83b7\u6279<\/i><i>NDA<\/i><i>\u53ca\u5e02\u573a\u5360\u6709\u7387\u6709\u7740\u91cd\u8981\u610f\u4e49\u3002\u540c\u65f6\uff0c\u6211\u4eec\u53d1\u73b0<\/i><i>JP001<\/i><i>\u8054\u7528<\/i><i>PD-1<\/i><i>\u53ef\u589e\u5f3a<\/i><i>PD-1<\/i><i>\u5bf9<\/i><i>GBM<\/i><i>\u7684\u654f\u611f\u6027\uff0c\u6b63\u5c31\u6b64\u79ef\u6781\u5728\u7f8e\u56fd\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\u8ba1\u5212\u3002<\/i><\/p>\n<p><i>\u6211\u4eec\u6b63\u5728\u5e03\u5c40\u7f8e\u56fd\uff0c\u4e2d\u56fd\u5927\u9646\u53ca\u4e2d\u56fd\u53f0\u6e7e\u4e09\u5730\u56fd\u9645\u591a\u4e2d\u5fc3\u7684<\/i><i>II\/III<\/i><i>\u671f\u8bd5\u9a8c\uff0c\u5e76\u5df2\u5411\u4e2d\u56fd<\/i><i>CDE<\/i><i>\uff08\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff09\u7533\u8bf7<\/i><i>PRE-IND<\/i><i>\u4f1a\u8bae\u3002\u6211\u76f8\u4fe1\uff0c<\/i><i>JP001<\/i><i>\u5c06\u6210\u4e3a\u4e00\u4e2a\u65b0\u836f\u7b56\u7565\u521b\u65b0\u7684\u6210\u529f\u6848\u4f8b\uff0c\u52a9\u529b\u66f4\u591a\u66f4\u5feb\u5730\u5f00\u53d1\u51fa\u80fd\u771f\u6b63\u6ee1\u8db3\u60a3\u8005\u9700\u6c42\u7684\u6297\u764c\u65b0\u836f\u3002<\/i><i>\u201d<\/i><\/p>\n<p>JP001\u7684\u4e3b\u8981\u7814\u7a76\u8005\uff08PI\uff09<b>\u5b63\u5321\u534e\u6559\u6388<\/b>\u4ea6\u8868\u793a\uff1a<\/p>\n<p><span>\u201c<\/span><i>\u81ea\u566c\u662f\u8bfa\u8d1d\u5c14\u5956\u7684\u9898\u76ee\uff0c\u5bf9\u6bcf\u4e2a\u7ec6\u80de\u4e0d\u53ef\u6216\u7f3a\u3002\u81ea\u566c\u7684\u6cbb\u7597\u9776\u70b9\u5b58\u5728\u4e8e\u6bcf\u4e00\u7c7b\u7ec6\u80de\u4e2d\uff0c\u5305\u62ec\u80bf\u7624\u7ec6\u80de\u3001\u80bf\u7624\u5fae\u73af\u5883\uff08<\/i><i>TME<\/i><i>\uff09\u4e2d\u7684\u7ec6\u80de\u548c\u4f53\u5185\u7684\u6b63\u5e38\u7ec6\u80de\u3002\u5f53\u7ec6\u80de\u7ecf\u53d7\u9965\u997f\u6216\u5316\u7597\uff08<\/i><i>CT<\/i><i>\uff09\u65f6\uff0c\u81ea\u566c\u901a\u5e38\u5177\u6709\u7ec6\u80de\u4fdd\u62a4\u4f5c\u7528\u3002\u81ea\u566c\u7684\u4fdd\u62a4\u4f5c\u7528\u5728\u80bf\u7624\u7ec6\u80de\u88ab\u653e\u5316\u7597\u653b\u51fb\u81f4\u6b7b\u65f6\u5c24\u4e3a\u7a81\u51fa\uff0c\u6240\u4ee5\u8fd1\u5e74\u6765\u6b63\u5728\u6210\u4e3a\u65b0\u6297\u764c\u836f\u7269\u5f00\u53d1\u7684\u91cd\u8981\u9776\u5411\u3002<\/i><\/p>\n<p><i>\u5355\u7528<\/i><i>JP001<\/i><i>\u5728<\/i><i>lymphangioleiomyomatosis<\/i><i>\u6dcb\u5df4\u8840\u7ba1\u5e73\u6ed1\u808c\u8089\u589e\u751f\u75c7\u8fd9\u4e2a\u7f55\u89c1\u75c5\u4f1a\u5f88\u6709\u6548<\/i><i>\uff0c<\/i><i>\u5bf9\u5176\u4ed6\u591a\u6570\u764c\u75c7<\/i><i>\uff0c<\/i><i>\u8054\u5408\u5404\u79cd\u6297\u80bf\u7624\u7597\u6cd5\u6548\u679c\u66f4\u4f73\u3002<\/i><i>JP001<\/i><i>\u7684\u57fa\u672c\u539f\u7406\u4e5f\u63d0\u793a\uff0c\u5176\u4f18\u70b9\u4e3a\u5177\u6709\u6297\u764c\u836f\u7269\u589e\u654f\u6548\u679c\uff0c\u4e14\u5df2\u5728<\/i><i>30%+<\/i><i>\u7684\u665a\u671f\u764c\u75c7\u4e0a\u770b\u5230\u4e34\u5e8a\u4ef7\u503c\u3002\u4f5c\u4e3a\u6297\u764c\u589e\u654f\u5242\uff0c\u65e0\u6392\u4ed6\u6027\uff0c\u5e02\u573a\u66f4\u5927\uff0c\u5982\u8d1d\u4f10<\/i><i>avastine<\/i><i>\uff0c\u53f7\u79f0<\/i><i>2025<\/i><i>\u5168\u7403\u6709<\/i><i>120<\/i><i>\u4ebf\u7f8e\u5143\u7684\u5e02\u573a\uff0c\u5355\u7528\u867d\u7136\u6ca1\u6709\u6548\u679c\uff0c\u4f46\u8054\u5408\u7528\u836f\u5e02\u573a\u6781\u5927\u3002<\/i><i>\u201d<\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5317\u4eac2021\u5e748\u670820\u65e5 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