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\u5728\u5168\u7403\uff0c\u963f\u666e\u7c73\u53f8\u7279\u7247\u5df2\u572850\u591a\u4e2a\u56fd\u5bb6\u548c\u5e02\u573a\u83b7\u6279\uff0c\u5176\u5728\u7f8e\u56fd\u83b7\u6279\u7684\u9002\u5e94\u75c7\u5305\u62ec\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u6d3b\u52a8\u6027\u94f6\u5c51\u75c5\u6027\u5173\u8282\u708e\u3001\u7528\u4e8e\u6cbb\u7597\u7b26\u5408\u63a5\u53d7\u5149\u7597\u6216\u7cfb\u7edf\u6cbb\u7597\u6307\u5f81\u7684\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u6591\u5757\u72b6\u94f6\u5c51\u75c5\u7684\u6210\u4eba\u60a3\u8005\u3001\u4ee5\u53ca\u7528\u4e8e\u6cbb\u7597\u4e0e\u767d\u585e\u6c0f\u75c5\u76f8\u5173\u7684\u6210\u4eba\u53e3\u8154\u6e83\u75a1\u60a3\u8005\u3002<\/p>\n<\/p>\n

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[1]<\/sup> \u4e2d\u534e\u533b\u5b66\u4f1a\u76ae\u80a4\u6027\u75c5\u5b66\u5206\u4f1a\u94f6\u5c51\u75c5\u4e13\u4e1a\u59d4\u5458\u4f1a.\u4e2d\u56fd\u94f6\u5c51\u75c5\u8bca\u7597\u6307\u5357(2018\u7b80\u7248)[J].\u4e2d\u534e\u76ae\u80a4\u79d1\u6742\u5fd7,2019,52(4):223-230.<\/span><\/p>\n<\/td>\n<\/tr>\n

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[2]<\/sup> Chen, K., Wang, G., Jin, H., Xu, J., Zhu, X., Zheng, M., & Gu, H. (2017). Clinic characteristics of psoriasis in China: a nationwide survey in over 12000 patients. Oncotarget<\/i>, 8<\/i>(28), 46381\u201346389. https:\/\/doi.org\/10.18632\/oncotarget.18453<\/span><\/p>\n<\/td>\n<\/tr>\n

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[3]<\/sup> Lebwohl, M. G., Bachelez, H., Barker, J., Girolomoni, G., Kavanaugh, A., Langley, R. G., … & van de Kerkhof, P. C. (2014). Patient perspectives in the management of psoriasis: results from the population-based Multinational Assessment of Psoriasis and Psoriatic Arthritis Survey. Journal of the American Academy of Dermatology<\/i>, 70<\/i>(5), 871-881.<\/span><\/p>\n<\/td>\n<\/tr>\n

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[4]<\/sup> Papp, K., Reich, K., Leonardi, C. L., Kircik, L., Chimenti, S., Langley, R. G., … & Griffiths, C. E. (2015). Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, in patients with moderate to severe plaque psoriasis: results of a phase III, randomized, controlled trial (Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis [ESTEEM] 1). Journal of the American Academy of Dermatology<\/i>, 73<\/i>(1), 37-49.<\/span><\/p>\n<\/td>\n<\/tr>\n

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[5]<\/sup> Paul, C., Cather, J., Gooderham, M., Poulin, Y., Mrowietz, U., Ferrandiz, C., … & Gottlieb, A. B. (2015). Efficacy and safety of apremilast, an oral phosphodiesterase 4 inhibitor, in patients with moderate\u2013to\u2013severe plaque psoriasis over 52 weeks: a phase III, randomized controlled trial (ESTEEM 2). British Journal of Dermatology<\/i>, 173<\/i>(6), 1387-1399.<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[6]<\/sup> Crowley J,Thaçi D,Joly P,et al.Long-term safety and tolerability of apremilast in patients with psoriasis:Pooled safety analysis for\u2265156 weeks from 2 phase 3,randomized,controlled trials(ESTEEM 1 and 2).J Am Acad Dermatol.2017 Aug;77(2):310-317.e1.doi:10.1016\/j.jaad.2017.01.052.Epub 2017 Apr 14.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n","protected":false},"excerpt":{"rendered":"

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[2] Chen, K., Wang, G., Jin, H., Xu, J., Zhu, X., Zheng, M., & Gu, H. (2017). Clinic characteristics of psoriasis in China: a nationwide survey in over 12000 patients. Oncotarget, 8(28), 46381\u201346389. https:\/\/doi.org\/10.18632\/oncotarget.18453 [3] Lebwohl, M. 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