{"id":41099,"date":"2021-08-16T19:00:00","date_gmt":"2021-08-16T12:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021081619000041099"},"modified":"2021-08-16T21:38:10","modified_gmt":"2021-08-16T13:38:10","slug":"%e4%ba%98%e5%96%9c%e7%94%9f%e7%89%a9%e4%b8%8e%e6%98%8e%e6%b5%8e%e7%94%9f%e7%89%a9%e8%be%be%e6%88%90%e5%90%88%e4%bd%9c%ef%bc%8c%e5%b0%86%e9%92%88%e5%af%b9cldn18-2%e9%98%b3%e6%80%a7%e5%ae%9e%e4%bd%93","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021081619000041099","title":{"rendered":"\u4e98\u559c\u751f\u7269\u4e0e\u660e\u6d4e\u751f\u7269\u8fbe\u6210\u5408\u4f5c\uff0c\u5c06\u9488\u5bf9CLDN18.2\u9633\u6027\u5b9e\u4f53\u7624\u5f00\u53d1\u65b0\u578b\u514d\u75ab\u7ec6\u80de\u7597\u6cd5"},"content":{"rendered":"\n\n\n
\"\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u4e2d\u56fd\u82cf\u5dde\u3001\u4e0a\u6d77\u548c\u7f8e\u56fd\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u5e15\u7f57\u5965\u56fe2021\u5e748\u670816\u65e5 \/\u7f8e\u901a\u793e\/ — \u4e98\u559c\u751f\u7269\u79d1\u6280\u96c6\u56e2\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aGRCL\uff1b\u7b80\u79f0\u201c\u4e98\u559c\u751f\u7269\u201d\uff09\u4e00\u5bb6\u81f4\u529b\u4e8e\u5f00\u53d1\u9ad8\u6548\u3001\u7ecf\u6d4e\u7684\u7ec6\u80de\u7597\u6cd5\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u7684\u5168\u7403\u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4eca\u5929\u5ba3\u5e03\u4e0e\u521b\u65b0\u751f\u7269\u5236\u836f\u4f01\u4e1a\u660e\u6d4e\u751f\u7269\u5236\u836f\uff08\u5317\u4eac\uff09\u6709\u9650\u516c\u53f8\uff08\u7b80\u79f0\u201c\u660e\u6d4e\u751f\u7269\u201d\uff09\u6b63\u5f0f\u7b7e\u7f72\u4e00\u9879\u72ec\u5bb6\u6388\u6743\u534f\u8bae\uff0c\u53cc\u65b9\u5c06\u805a\u7126Claudin 18.2\uff08\u201cCLDN18.2\u201d\uff09\u9776\u70b9\uff0c\u901a\u8fc7\u57fa\u56e0\u5de5\u7a0b\u6280\u672f\u5f00\u53d1\u4e00\u7cfb\u5217\u65b0\u578b\u7ec6\u80de\u7597\u6cd5\u3002<\/p>\n

\n<\/p><\/div>\n

\u6b64\u6b21\u5408\u4f5c\uff0c\u4e98\u559c\u751f\u7269\u65e8\u5728\u5145\u5206\u501f\u52a9\u81ea\u8eab\u5728\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\u9886\u57df\u7684\u6df1\u539a\u79ef\u7d2f\uff0c\u7ed3\u5408\u660e\u6d4e\u751f\u7269\u7684\u5dee\u5f02\u5316\u5168\u4eba\u6e90CLDN18.2\u6297\u4f53\uff0c\u8fdb\u4e00\u6b65\u5f00\u53d1\u3001\u751f\u4ea7\u53ca\u5546\u4e1a\u5316\u521b\u65b0\u578b\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\uff0c\u60e0\u53ca\u5e7f\u5927CLDN18.2\u9633\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u3002<\/p>\n

CLDN18.2\u662f\u4e00\u79cd\u80bf\u7624\u7279\u5f02\u6027\u6807\u5fd7\u7269\uff0c\u5728\u591a\u79cd\u80bf\u7624\u7ec4\u7ec7\u4e2d\u51fa\u73b0\u9ad8\u8868\u8fbe\uff0c\u5305\u62ec\u80c3\u6216\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u764c\u3001\u80f0\u817a\u764c\u548c\u98df\u7ba1\u764c\uff1b\u540c\u65f6\uff0c\u5b83\u5728\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u7684\u8868\u8fbe\u5f88\u4f4e\u3002\u56e0\u6b64\uff0cCLDN18.2\u88ab\u89c6\u4e3a\u5f00\u53d1\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\u7684\u4f18\u8d28\u9776\u70b9\u4e4b\u4e00\uff0c\u5177\u6709\u5e7f\u6cdb\u7684\u4e34\u5e8a\u83b7\u76ca\u6f5c\u529b\u3002\u5c24\u5176\u5728\u80c3\u764c\u60a3\u8005\u4e2d\uff0cCLDN18.2\u7684\u9633\u6027\u7387\u7ea6\u4e3a70%[1]<\/sup>\uff1b\u800c\u5728\u5168\u7403\u8303\u56f4\u5185\uff0c\u80c3\u764c\u53c8\u662f\u6700\u9ad8\u53d1\u7684\u764c\u75c7\u4e4b\u4e00\uff0c\u4e5f\u662f\u7b2c\u4e8c\u5927\u764c\u75c7\u6b7b\u4ea1\u539f\u56e0\u3002\u6570\u636e\u663e\u793a\uff0c\u4ec52018\u5e74\uff0c\u80c3\u764c\u65b0\u53d1\u75c5\u4f8b\u65701,033,701\uff0c\u6b7b\u4ea1\u75c5\u4f8b\u6570782,685[2]<\/sup>\uff0c\u4e34\u5e8a\u6cbb\u7597\u73b0\u72b6\u5b58\u5728\u5de8\u5927\u6311\u6218\u3002 <\/p>\n

\u201c\u77ed\u77ed\u51e0\u5e74\u4ee5\u6765\uff0c\u4e98\u559c\u751f\u7269\u9488\u5bf9\u8840\u6db2\u80bf\u7624\u548c\u5b9e\u4f53\u7624\u6cbb\u7597\u7684\u4ea7\u54c1\u7814\u53d1\u53d6\u5f97\u4e86\u957f\u8db3\u7684\u8fdb\u5c55\uff0c\u6253\u9020\u4e86\u4e00\u7cfb\u5217\u521b\u65b0\u578bCAR-T\u7ec6\u80de\u7597\u6cd5\u3002\u201d\u4e98\u559c\u751f\u7269\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u957f\u517c\u9996\u5e2d\u6267\u884c\u5b98\u66f9\u536b\uff08William Cao\uff09\u535a\u58eb\u8868\u793a\uff0c\u201c\u6b64\u6b21\u4e0e\u660e\u6d4e\u751f\u7269\u5f3a\u5f3a\u8054\u624b\uff0c\u6807\u5fd7\u7740\u4e98\u559c\u8fdb\u4e00\u6b65\u52a0\u5927\u4e86\u5728\u5b9e\u4f53\u7624\u9886\u57df\u7684\u6295\u5165\u4e0e\u5e03\u5c40\u3002\u672a\u6765\uff0c\u6211\u4eec\u8fd8\u4f1a\u6301\u7eed\u6269\u5927\u534f\u4f5c\uff0c\u9074\u9009\u66f4\u591a\u4f18\u8d28\u9776\u70b9\uff0c\u7ed3\u5408\u516c\u53f8\u5177\u6709\u9ad8\u5ea6\u5dee\u5f02\u5316\u7684\u4e13\u5229\u6280\u672f\u5e73\u53f0\uff0c\u6700\u5927\u5316\u5730\u91ca\u653e\u5728\u7ec6\u80de\u4e0e\u57fa\u56e0\u7597\u6cd5\u9886\u57df\u7684\u521b\u65b0\u52bf\u80fd\uff0c\u9020\u798f\u5168\u7403\u764c\u75c7\u60a3\u8005\u3002\u201d<\/p>\n

\u201c\u51ed\u501fEnhanced CAR\u6280\u672f\uff0c\u4e98\u559c\u751f\u7269\u6b63\u4e0d\u65ad\u63d0\u5347CAR-T\u7ec6\u80de\u5728\u6cbb\u7597\u5b9e\u4f53\u7624\u4e2d\u7684\u6548\u679c\u53ca\u6301\u4e45\u6027\u3002\u57fa\u4e8e\u6b64\u524d\u4e00\u9879\u7814\u7a76\u8005\u53d1\u8d77\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\uff0cEnhanced CAR-T\u7ec6\u80de\u7597\u6cd5\u5c55\u73b0\u51fa\u4e86\u826f\u597d\u7684\u8010\u53d7\u6027\u548c\u521d\u6b65\u7684\u7597\u6548\uff0c\u76f8\u5173\u7ed3\u679c\u5373\u5c06\u5728Nature<\/i>\u5b50\u520aCellular&Molecular Immunology<\/i>\u4e0a\u53d1\u8868\u3002\u201d \u4e98\u559c\u751f\u7269\u9ad8\u7ea7\u526f\u603b\u88c1\u3001\u7814\u53d1\u8d1f\u8d23\u4eba\u6c88\u8fde\u519b\u535a\u58eb\u8868\u793a\uff0c\u201c\u975e\u5e38\u9ad8\u5174\u80fd\u643a\u624b\u660e\u6d4e\u751f\u7269\uff0c\u7ed3\u5408\u53cc\u65b9\u5404\u81ea\u4f18\u52bf\uff0c\u4e0d\u65ad\u6253\u9020\u66f4\u591a\u9488\u5bf9CLDN18.2\u9633\u6027\u764c\u79cd\u7684\u65b0\u4e00\u4ee3\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\uff0c\u6301\u7eed\u91ca\u653e\u6211\u4eec\u4e0b\u4e00\u4ee3Enhanced CAR\u6280\u672f\u5728\u9488\u5bf9\u5b9e\u4f53\u7624\u7597\u6cd5\u7814\u53d1\u4e2d\u7684\u5de8\u5927\u6f5c\u80fd\u3002\u201d<\/p>\n

\u660e\u6d4e\u751f\u7269\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u957f\u517c\u9996\u5e2d\u6267\u884c\u5b98\u9773\u7167\u5b87\u535a\u58eb\u8868\u793a\uff0c\u201c\u660e\u6d4e\u751f\u7269\u901a\u8fc7\u72ec\u521b\u7684STEP\u53caCAP\u6297\u4f53\u5de5\u7a0b\u5e73\u53f0\u5f00\u53d1\u51fa\u7279\u5f02\u6027CLDN18.2\u6297\u4f53\uff0c\u5bf9\u6297\u4f53\u7684\u7ed3\u5408\u8868\u4f4d\u548c\u4eb2\u548c\u529b\u8fdb\u884c\u4e86\u7cbe\u7ec6\u7684\u8c03\u8282\uff1b\u5c06\u5176\u5e94\u7528\u4e8e CAR-T\u540e\uff0c\u6709\u671b\u66f4\u7279\u5f02\u5730\u6e05\u9664CLDN18.2\u9ad8\u8868\u8fbe\u80bf\u7624\u7ec6\u80de\uff0c\u4ea7\u751f\u76f8\u5bf9\u8f83\u5c0f\u7684\u526f\u4f5c\u7528\u3002\u4e98\u559c\u751f\u7269\u662f\u7ec6\u80de\u4e0e\u57fa\u56e0\u6cbb\u7597\u9886\u57df\u7684\u5f15\u9886\u8005\u4e4b\u4e00\uff0c\u5f88\u8363\u5e78\u80fd\u4e0e\u5176\u8fbe\u6210\u5408\u4f5c\u3002\u501f\u52a9\u4e98\u559c\u5728\u7ec6\u80de\u7597\u6cd5\u65b9\u9762\u7684\u6df1\u539a\u5e95\u8574\u4ee5\u53ca\u5176\u72ec\u6709\u7684\u4e13\u5229\u6280\u672f\uff0c\u7ed3\u5408\u660e\u6d4e\u751f\u7269\u5177\u6709\u5dee\u5f02\u5316\u4f18\u52bf\u7684CLDN18.2\u6297\u4f53\u4ea7\u54c1\uff0c\u671f\u5f85\u65e9\u65e5\u4e3a\u5b9e\u4f53\u7624\u5e26\u6765\u66f4\u591a\u5148\u8fdb\u7684\u6cbb\u7597\u65b9\u6848\u3002\u201d<\/p>\n

\u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0c\u660e\u6d4e\u751f\u7269\u5c06\u83b7\u5f97\u4e00\u7b14\u9884\u4ed8\u6b3e\uff0c\u5e76\u6709\u6743\u83b7\u5f97\u57fa\u4e8e\u975e\u4e34\u5e8a\u9a8c\u8bc1\u3001\u4e34\u5e8a\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u6210\u679c\u7684\u91cc\u7a0b\u7891\u6b3e\u9879\uff0c\u4ee5\u53ca\u4f4e\u4e2a\u4f4d\u6570\u7684\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002<\/p>\n

\u5173\u4e8e<\/b>CLDN18.2<\/b><\/p>\n

CLDN18.2\u662f\u4e00\u79cd\u5177\u6709\u56db\u4e2a\u8de8\u819c\u533a\u548c\u4e24\u4e2a\u7ec6\u80de\u5916\u73af\u7684\u5c0f\u578b\u8de8\u819c\u86cb\u767d\uff0c\u5728\u76f8\u5f53\u4e00\u90e8\u5206\u7684\u80c3\u764c\u548c\u98df\u7ba1\u764c\u80bf\u7624\u7ec4\u7ec7\u4e2d\u51fa\u73b0\u9ad8\u8868\u8fbe\u3002\u5176\u7279\u5f02\u6027\u8868\u8fbe\u4f7f\u5f97CLDN18.2\u6210\u4e3a\u6cbb\u7597\u80c3\u6216\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u764c\u3001\u80f0\u817a\u764c\u7b49\u764c\u75c7\u7684\u6f5c\u529b\u9776\u70b9\u3002\u603b\u4f53\u800c\u8a00\uff0cCLDN18.2\u5728\u7ea670%\u7684\u80c3\u764c\u60a3\u8005\u548c\u7ea660%\u7684\u80f0\u817a\u764c\u60a3\u8005\u7684\u80bf\u7624\u7ec4\u7ec7\u4e2d\u5448\u73b0\u9633\u6027\u8868\u8fbe\u3002\u4ee5CLDN18.2\u4e3a\u9776\u70b9\u5f00\u53d1\u7684CLDN18.2\u7279\u5f02\u6027\u6297\u4f53\u5728\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u8868\u73b0\u51fa\u4e86\u6297\u80bf\u7624\u6d3b\u6027[3]<\/sup>\u3002<\/p>\n

\u5173\u4e8e<\/b>Enhanced CAR<\/b><\/p>\n

Enhanced CAR\u662f\u4e98\u559c\u751f\u7269\u5177\u6709\u77e5\u8bc6\u4ea7\u6743\u7684\u4e13\u5229\u6280\u672f\uff0c\u53ef\u901a\u8fc7\u514b\u670d\u514d\u75ab\u6291\u5236\u6027\u80bf\u7624\u5fae\u73af\u5883\u548c\/\u6216\u589e\u52a0\u7ec6\u80de\u56e0\u5b50\u4fe1\u53f7\u4f20\u5bfc\uff0c\u8fdb\u4e00\u6b65\u589e\u5f3aCAR-T\u7ec6\u80de\u7684\u529f\u80fd\u3002\u4e98\u559c\u751f\u7269\u5229\u7528\u57fa\u56e0\u6280\u672f\u7f16\u8f91CAR-T\u7ec6\u80de\u4e0a\u8868\u8fbe\u7684\u67d0\u79cd\u68c0\u67e5\u70b9\u6216\/\u548c\u7ec6\u80de\u56e0\u5b50\u6216\u53d7\u4f53\uff0c\u51cf\u5c11\u6216\u53bb\u9664\u80bf\u7624\u7ec6\u80de\u53ca\u80bf\u7624\u7ec4\u7ec7\u4e2d\u5176\u4ed6\u6291\u5236\u6027\u514d\u75ab\u7ec6\u80de\u5bf9\u4e8eCAR-T\u7ec6\u80de\u7684\u6f5c\u5728\u6291\u5236\u6548\u5e94\uff0c\u4ee5\u5bf9\u6297\u80bf\u7624\u5fae\u73af\u5883\uff0c\u63d0\u9ad8CAR-T\u7684\u6548\u7528\u3002\u4e98\u559c\u751f\u7269\u7684\u4e0b\u4e00\u4ee3Enhanced CAR\u6280\u672f\u53ef\u4ee5\u88ab\u5e94\u7528\u4e8e\u4e0d\u540c\u9776\u70b9\u7684CAR-T\u7ec6\u80de\u7684\u6539\u9020\uff0c\u4ee5\u7528\u4e8e\u6570\u79cd\u5b9e\u4f53\u7624\u7684\u6cbb\u7597\u3002<\/p>\n

\u5173\u4e8e\u4e98\u559c\u751f\u7269<\/b><\/p>\n

\u4e98\u559c\u751f\u7269\u79d1\u6280\u96c6\u56e2\uff08\u7b80\u79f0\u201c\u4e98\u559c\u751f\u7269\u201d\uff09\u662f\u4e00\u5bb6\u81f4\u529b\u4e8e\u53d1\u73b0\u548c\u5f00\u53d1\u7a81\u7834\u6027\u7ec6\u80de\u7597\u6cd5\u7684\u5168\u7403\u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u5236\u836f\u516c\u53f8\u3002\u5229\u7528\u5176\u5f00\u521b\u6027FasTCAR\u548cTruUCAR\u6280\u672f\u5e73\u53f0\uff0c\u4e98\u559c\u751f\u7269\u6b63\u5728\u5f00\u53d1\u591a\u9879\u81ea\u4f53\u548c\u540c\u79cd\u5f02\u4f53\u7684\u4e30\u5bcc\u4e34\u5e8a\u9636\u6bb5\u764c\u75c7\u6cbb\u7597\u4ea7\u54c1\u7ba1\u7ebf\u3002\u8fd9\u4e9b\u4ea7\u54c1\u6709\u671b\u653b\u514b\u4f20\u7edfCAR-T\u7597\u6cd5\u6301\u7eed\u5b58\u5728\u7684\u91cd\u5927\u884c\u4e1a\u6311\u6218\uff0c\u5305\u62ec\u751f\u4ea7\u65f6\u95f4\u957f\u3001\u751f\u4ea7\u8d28\u91cf\u6b20\u4f73\u3001\u6cbb\u7597\u6210\u672c\u9ad8\u548c\u5bf9\u5b9e\u4f53\u7624\u7f3a\u4e4f\u6709\u6548\u6cbb\u7597\u65b9\u6848\u7b49\u3002\u5982\u9700\u8fdb\u4e00\u6b65\u4e86\u89e3\u4e98\u559c\u751f\u7269\uff0c\u8bf7\u8bbf\u95eewww.gracellbio.com\/<\/a>\u5173\u6ce8\u9886\u82f1\u8d26\u53f7@GracellBio<\/a>\u3002<\/p>\n

\u5173\u4e8e\u660e\u6d4e\u751f\u7269<\/b><\/p>\n

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\u5173\u4e8e\u524d\u77bb\u6027\u9648\u8ff0\u7684\u8b66\u6212\u6027\u58f0\u660e<\/b><\/p>\n

\u8be5\u65b0\u95fb\u7a3f\u4e2d\u9488\u5bf9\u672a\u6765\u9884\u671f\u3001\u8ba1\u5212\u3001\u524d\u666f\u4ee5\u53ca\u5176\u4ed6\u975e\u5386\u53f2\u4e8b\u5b9e\u7684\u58f0\u660e\u53ef\u80fd\u5305\u542b\u6839\u636e\u300a1995 \u5e74\u79c1\u4eba\u8bc1\u5238\u8bc9\u8bbc\u6539\u9769\u6cd5\u6848\u300b\uff08Private Securities Litigation Reform Act of 1995\uff09\u4e0b\u5b9a\u4e49\u7684\u201c\u524d\u77bb\u6027\u58f0\u660e\u201d\u3002\u8fd9\u4e9b\u58f0\u660e\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u4e0e\u672c\u6b21\u53d1\u884c\u7684\u9884\u8ba1\u4ea4\u6613\u53ca\u5b8c\u6210\u65f6\u95f4\u76f8\u5173\u7684\u58f0\u660e\u3002\u8fd9\u4e9b\u58f0\u660e\u53ef\u80fd\u4f46\u4e0d\u4e00\u5b9a\u5305\u542b\u4e0b\u5217\u8bcd\u6c47\u4ee5\u53ca\u76f8\u5bf9\u5e94\u7684\u5426\u5b9a\u5f62\u5f0f\u6216\u76f8\u4f3c\u7684\u8bcd\u6c47\uff1a\u76ee\u7684\u4e3a\u3001\u9884\u671f\u3001\u76f8\u4fe1\u3001 \u4f30\u8ba1\u3001\u9884\u8ba1\u3001\u9884\u6d4b\u3001\u6253\u7b97\u3001\u53ef\u80fd\u3001\u524d\u666f\u3001\u8ba1\u5212\u3001\u6f5c\u5728\u3001\u63a8\u60f3\u3001\u62df\u5b9a\u3001\u5bfb\u6c42\u3001\u53ef\u80fd\u3001\u5e94\u8be5\u3001\u5c06\u3002\u7531\u4e8e\u5404\u79cd\u91cd\u8981\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4e0e\u524d\u77bb\u6027\u58f0\u660e\u6709\u91cd\u5927\u5dee\u5f02\uff0c\u4e5f\u65e0\u6cd5\u786e\u4fdd\u4efb\u4f55\u524d\u77bb\u6027\u58f0\u660e\u4f1a\u5b9e\u73b0\u3002\u8fd9\u4e9b\u91cd\u8981\u56e0\u7d20\u5305\u62ec\u4e98\u559c\u751f\u7269\u6700\u8fd1\u5728\u5e74\u5ea6\u62a5\u544a20-F\u8868\u5355\u4e2d\u7684\u300a\u98ce\u9669\u56e0\u7d20\u300b\u7ae0\u8282\u6240\u63d0\u53ca\u7684\u56e0\u7d20\uff0c\u4ee5\u53ca\u4e98\u559c\u751f\u7269\u540e\u7eed\u5411\u7f8e\u56fd\u8bc1\u76d1\u4f1a\u671f\u540e\u5448\u62a5\u4e2d\u5173\u4e8e\u6f5c\u5728\u98ce\u9669\u3001\u4e0d\u786e\u5b9a\u6027\u4ee5\u53ca\u5176\u4ed6\u91cd\u8981\u56e0\u7d20\u7684\u8ba8\u8bba\u3002\u4efb\u4f55\u672c\u58f0\u660e\u4e2d\u7684\u524d\u77bb\u6027\u58f0\u660e\u4ec5\u53cd\u5e94\u5f53\u524d\u7684\u9884\u671f\uff0c\u4e98\u559c\u751f\u7269\u5e76\u65e0\u8d23\u4efb\u516c\u5f00\u66f4\u65b0\u6216\u56de\u987e\u4efb\u4e00\u524d\u77bb\u6027\u58f0\u660e\uff0c\u65e0\u8bba\u662f\u57fa\u4e8e\u65b0\u4fe1\u606f\u3001\u672a\u6765\u4e8b\u4ef6\u6216\u662f\u5176\u4ed6\u539f\u56e0\u3002\u8bf7\u8bfb\u8005\u4e0d\u8981\u5728\u672c\u65b0\u95fb\u7a3f\u51fa\u7248\u65e5\u4e4b\u540e\u4f9d\u8d56\u524d\u77bb\u6027\u58f0\u660e\u3002<\/p>\n

[1] Clinical Implications of Claudin18.2 Expression in Patients With Gastric Cancer
[2] Hsu A, Chudasama R, Almhanna K, Raufi A. Targeted therapies for gastroesophageal cancers. Ann. Transl. Med. (2020) 8:1104. doi: 10.21037\/atm-20-3265
[3] The full-length Claudin 18.2 to accelerate antibody drug development<\/span><\/p>\n

\u5a92\u4f53\u8054\u7cfb\u4eba
<\/b>Marvin Tang<\/span>
<\/b>marvin.tang@gracellbio.com<\/a><\/p>\n

\u6295\u8d44\u8005\u8054\u7cfb\u4eba
<\/b>Gracie Tong<\/span>
<\/b>gracie.tong@gracellbio.com<\/a><\/p>\n

<\/div>\n

\u76f8\u5173\u94fe\u63a5 :<\/p>\n

http:\/\/www.gracellbio.com\/<\/p>\n","protected":false},"excerpt":{"rendered":"

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\u5173\u4e8e\u660e\u6d4e\u751f\u7269 \u660e\u6d4e\u751f\u7269\u5236\u836f\uff08\u5317\u4eac\uff09\u6709\u9650\u516c\u53f8\uff08\u7b80\u79f0\u201c\u660e\u6d4e\u751f\u7269\u201d\uff09\u662f\u4e00\u5bb6\u7531\u66fe\u957f\u671f\u5c31\u804c\u4e8e\u7f8e\u56fd\u8457\u540d\u751f\u7269\u5236\u836f\u516c\u53f8\u7684\u4e13\u5bb6\u56e2\u961f\u7ec4\u5efa\u7684\uff0c\u4e13\u6ce8\u4e8e\u7cbe\u51c6\u514d\u75ab\u6cbb\u7597\uff0c\u901a\u8fc7\u5168\u7403\u9886\u5148\u7684\u6297\u4f53\u5de5\u7a0b\u6280\u672f\u9a71\u52a8\u521b\u65b0\u836f\u7269\u5f00\u53d1\u7684\u751f\u7269\u79d1\u6280\u4f01\u4e1a\u3002\u516c\u53f8\u5f00\u53d1\u7684\u5177\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684\u5305\u62ecStructure-based Targeted Evolution Platform\uff08STEP\uff09\u53caCell-based Antibody 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[1] Clinical Implications of Claudin18.2 Expression in Patients With Gastric Cancer[2] Hsu A, Chudasama R,… Read 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