{"id":40654,"date":"2021-08-10T08:48:00","date_gmt":"2021-08-10T01:48:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021081008480040654"},"modified":"2021-08-10T21:37:55","modified_gmt":"2021-08-10T13:37:55","slug":"%e5%86%8d%e9%bc%8e%e5%8c%bb%e8%8d%af%e5%85%ac%e5%b8%832021%e5%b9%b4%e7%ac%ac%e4%ba%8c%e5%ad%a3%e5%ba%a6%e8%b4%a2%e5%8a%a1%e4%b8%9a%e7%bb%a9","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021081008480040654","title":{"rendered":"\u518d\u9f0e\u533b\u836f\u516c\u5e032021\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u8d22\u52a1\u4e1a\u7ee9"},"content":{"rendered":"

\u4e0a\u6d77\u548c\u65e7\u91d1\u5c71<\/span>2021\u5e748\u670810<\/span>\u65e5 \/\u7f8e\u901a\u793e\/ — \u518d\u9f0e\u533b\u836f\uff08\u7eb3\u65af\u8fbe\u514b\u4ee3\u7801\uff1aZLAB\uff1b\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a9688\uff09\u516c\u5e03\u4e862021\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u7684\u8d22\u52a1\u4e1a\u7ee9\uff0c\u4ee5\u53ca\u6700\u8fd1\u7684\u4ea7\u54c1\u4eae\u70b9\u548c\u516c\u53f8\u8fdb\u5c55\u3002<\/p>\n

\u518d\u9f0e\u533b\u836f\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u957f\u517c\u9996\u5e2d\u6267\u884c\u5b98\u675c\u83b9\u535a\u58eb\u8868\u793a\uff1a\u201c\u5728\u7b2c\u4e8c\u5b63\u5ea6\uff0c\u518d\u9f0e\u4e00\u5982\u65e2\u5f80\u5feb\u901f\u9ad8\u6548\u5730\u63a8\u8fdb\u5404\u9879\u4e1a\u52a1\u8fdb\u5c55\u3002\u64ce\u4e50\u5728\u4e2d\u56fd\u6210\u529f\u4e0a\u5e02\uff0c\u6210\u4e3a\u518d\u9f0e\u5728\u80c3\u764c\u4ea7\u54c1\u7ba1\u7ebf\u4e2d\u7684\u7b2c\u4e00\u4e2a\u5546\u4e1a\u5316\u4ea7\u54c1\uff0c\u672a\u6765\u518d\u9f0e\u6709\u671b\u5efa\u7acb\u8d77\u4e16\u754c\u9886\u5148\u7684\u80c3\u764c\u7ba1\u7ebf\u3002\u5219\u4e50\u548c\u7231\u666e\u76fe\u8d21\u732e\u4e86\u5f3a\u52b2\u7684\u6536\u5165\u589e\u957f\uff1b\u6211\u4eec\u4e0eMirati\u3001MacroGenics\u548cSchrödinger\u8fbe\u6210\u6218\u7565\u5408\u4f5c\uff0c\u8fdb\u4e00\u6b65\u52a0\u5f3a\u4e86\u6211\u4eec\u5728\u80bf\u7624\u65b9\u9762\u7684\u5b9e\u529b\u53ca\u5168\u7403\u7ba1\u7ebf\u3002<\/p>\n

2021\u5e74\uff0c\u6211\u4eec\u7684\u4ea7\u54c1\u7ba1\u7ebf\u4ecd\u6709\u8bb8\u591a\u503c\u5f97\u671f\u5f85\u7684\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff0c\u5305\u62ec\u7ebd\u518d\u4e50\u6709\u671b\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u793e\u533a\u83b7\u5f97\u6027\u7ec6\u83cc\u6027\u80ba\u708e\uff08CABP\uff09\u548c\u6025\u6027\u7ec6\u83cc\u6027\u76ae\u80a4\u548c\u76ae\u80a4\u7ed3\u6784\u611f\u67d3\uff08ABSSSI\uff09\u3002\u6211\u4eec\u4f1a\u7ee7\u7eed\u63a8\u8fdb\u4ea7\u54c1\u7684\u6ce8\u518c\uff0c\u5e76\u9884\u8ba1\u4e8e\u8fd1\u671f\u5411\u4e3b\u7ba1\u90e8\u95e8\u54a8\u8be2efgartigimod\u6ce8\u518c\u76f8\u5173\u5de5\u4f5c\u3002\u6b64\u5916\uff0c\u6211\u4eec\u9884\u8ba1\u4eca\u5e74\u8fd8\u4f1a\u6709\u8bb8\u591a\u91cd\u8981\u7684\u6570\u636e\u516c\u5e03\u548c\u66f4\u65b0\uff0c\u5305\u62ec\uff1a\u80bf\u7624\u7535\u573a\u6cbb\u7597\u7528\u4e8e\u5375\u5de2\u764c\u7684\u6cbb\u7597\u3001\u64ce\u4e50\u7528\u4e8e\u80c3\u80a0\u95f4\u8d28\u7624\u7684\u4e8c\u7ebf\u6cbb\u7597\u3001margetuximab\u7528\u4e8e\u80c3\u764c\u7684\u6cbb\u7597\u3001CLN-081\u7528\u4e8e\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u6cbb\u7597\u3001TPX-0022\u7528\u4e8e\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u548c\u80c3\u764c\u7684\u6cbb\u7597\u3001adagrasib\u7528\u4e8e\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u548c\u7ed3\u76f4\u80a0\u764c\u7684\u6cbb\u7597\uff0c\u4ee5\u53ca\u6211\u4eec\u5176\u4ed6\u62e5\u6709\u5168\u7403\u6743\u76ca\u7684\u5728\u7814\u4ea7\u54c1\u3002<\/p>\n

\u6211\u4eec\u6bd4\u4ee5\u5f80\u4efb\u4f55\u65f6\u5019\u90fd\u66f4\u52a0\u4e13\u6ce8\u4e8e\u6211\u4eec\u7684\u4f7f\u547d\uff1a\u5efa\u7acb\u4e00\u5bb6\u5168\u7403\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u516c\u53f8\uff0c\u4ee5\u6ee1\u8db3\u4e2d\u56fd\u548c\u4e16\u754c\u5404\u5730\u60a3\u8005\u4e9f\u9700\u7684\u533b\u7597\u9700\u6c42\u3002\u201d<\/p>\n

\u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\u53ca\u9884\u671f\u7684\u91cc\u7a0b\u7891<\/b><\/p>\n

\u80bf\u7624\u9886\u57df<\/b><\/p>\n

\u5219\u4e50<\/b>®<\/b>\uff08\u5c3c\u62c9\u5e15\u5229\uff09<\/b><\/p>\n

\u5219\u4e50\u662f\u4e00\u79cd\u53e3\u670d\u3001\u6bcf\u65e5\u4e00\u6b21\u7684\u5c0f\u5206\u5b50\u805a\uff08ADP-\u6838\u7cd6\uff09PARP 1\/2\u6291\u5236\u5242\uff0c\u662f\u552f\u4e00\u5728\u7f8e\u56fd\u3001\u6b27\u6d32\u548c\u4e2d\u56fd\u5185\u5730\uff08\u4ee5\u4e0b\u7b80\u79f0\u201c<\/span>\u4e2d\u56fd\u201d<\/span>\uff09\u83b7\u6279\u7684\u65e0\u8bba\u60a3\u8005\u751f\u7269\u6807\u8bb0\u7269\u72b6\u6001\u5982\u4f55\uff0c\u5747\u53ef\u5355\u836f\u7528\u4e8e\u5bf9\u542b\u94c2\u5316\u7597\u5b8c\u5168\u6216\u90e8\u5206\u7f13\u89e3\u7684\u665a\u671f\u4e0a\u76ae\u6027\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6216\u539f\u53d1\u6027\u8179\u819c\u60a3\u8005\u7ef4\u6301\u6027\u6cbb\u7597\u7684PARP\u6291\u5236\u5242\u3002<\/p>\n

\u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a<\/b><\/p>\n

\u518d\u9f0e\u533b\u836f\u8fd1\u51e0\u4e2a\u6708\u5728\u5219\u4e50\u8fdb\u9662\u65b9\u9762\u53d6\u5f97\u4e86\u957f\u8db3\u8fdb\u5c55\u3002\u4e8e2021\u5e743\u67081\u65e5\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f55\uff08NRDL\uff09\u5b9e\u65bd\u5f53\u65e5\u81f32021\u5e746\u670830\u65e5\u7684\u671f\u95f4\uff0c\u5219\u4e50\u7684\u8fdb\u9662\u6570\u91cf\u4e3a\u4e4b\u524d7\u500d\uff0c\u8fbe\u5230800\u4f59\u5bb6\u3002<\/p>\n

2021<\/b>\u5e74\u4ea7\u54c1\u9884\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff1a<\/b><\/p>\n

\u5b8c\u6210\u5219\u4e50\u8054\u5408tebotelimab\u7528\u4e8e\u80c3\u764c\u76841b\u671f\u4e34\u5e8a\u7814\u7a76\u7684\u60a3\u8005\u5165\u7ec4\u3002<\/p>\n

\u516c\u5e03\u5219\u4e50\u7528\u4e8e\u4e2d\u56fd\u5375\u5de2\u764c\u60a3\u8005\u4e00\u7ebf\u7ef4\u6301\u6cbb\u7597\u7684III\u671f\u4e34\u5e8a\u7814\u7a76PRIME\u7684\u4e3b\u8981\u7ed3\u679c\u3002<\/p>\n

\u4e89\u53d6\u5375\u5de2\u764c\u4e00\u7ebf\u9002\u5e94\u75c7\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f55\u3002<\/p>\n

\u7ee7\u7eed\u63a2\u7d22\u5176\u4ed6\u9002\u5e94\u75c7\u53ca\u4e0e\u5176\u4ed6\u836f\u7269\u8054\u7528\u7684\u673a\u4f1a\u3002<\/p>\n

\u80bf\u7624\u7535\u573a\u6cbb\u7597<\/b><\/p>\n

\u80bf\u7624\u7535\u573a\u6cbb\u7597\u662f\u4e00\u79cd\u5229\u7528\u7279\u5b9a\u7535\u573a\u9891\u7387\u5e72\u6270\u7ec6\u80de\u5206\u88c2\u7684\u7597\u6cd5\u3002<\/p>\n

\u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a<\/b><\/p>\n

2021\u5e747\u6708\uff0c\u518d\u9f0e\u533b\u836f\u5408\u4f5c\u4f19\u4f34Novocure\u516c\u5e03\u4e86II\u671f\u809d\u764c\u63a2\u7d22\u6027\u7814\u7a76HEPANOVA\u7814\u7a76\u7684\u6700\u7ec8\u7ed3\u679c\uff0c\u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30\u80bf\u7624\u7535\u573a\u6cbb\u7597\u8054\u5408\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u665a\u671f\u809d\u764c\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u572821\u540d\u53ef\u8bc4\u4f30\u7684\u60a3\u8005\u4e2d\uff0cHEPANOVA\u663e\u793a\u7684\u75be\u75c5\u63a7\u5236\u7387\u4e3a76%\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\u4e3a9.5%\uff0c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e3a5.8\u4e2a\u6708\uff0c\u8fd9\u4e9b\u60a3\u8005\u5747\u9884\u540e\u4e0d\u826f\u5e76\u5bf9\u836f\u7269\u6cbb\u7597\u66b4\u9732\u6709\u9650\u3002\u5728\u63a5\u53d7\u81f3\u5c1112\u5468\uff08n=11\uff09\u80bf\u7624\u7535\u573a\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u75be\u75c5\u63a7\u5236\u7387\u4e3a91%\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\u4e3a18%\u3002Novocure\u6b63\u79ef\u6781\u8bbe\u8ba1III\u671f\u5173\u952e\u6027\u7814\u7a76\uff0c\u8ba1\u5212\u5c06\u80bf\u7624\u7535\u573a\u6cbb\u7597\u4e0e\u73b0\u884c\u7684\u5e38\u89c4\u6cbb\u7597\uff08\u5305\u62ec\u514d\u75ab\u6cbb\u7597\uff09\u8054\u7528\u3002<\/p>\n

2021\u5e745\u6708\uff0c\u518d\u9f0e\u533b\u836f\u5408\u4f5c\u4f19\u4f34Novocure\u5ba3\u5e03\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u4e86\u5176\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u8fdb\u884c\u7684III\u671f\u5173\u952e\u7814\u7a76LUNAR\u7684\u5668\u68b0\u8c41\u514d\u7814\u7a76\uff08IDE\uff09\u8865\u5145\u6750\u6599\uff0c\u5176\u4e2d\u7eb3\u5165\u4e86\u72ec\u7acb\u6570\u636e\u76d1\u7763\u59d4\u5458\u4f1a\u5efa\u8bae\u7684\u7814\u7a76\u65b9\u6848\u53d8\u66f4\uff0c\u5c06\u5165\u7ec4\u8981\u6c42\u964d\u4f4e\u81f3276\u540d\u60a3\u8005\uff0c\u968f\u8bbf\u65f6\u95f4\u7f29\u77ed\u81f3\u6700\u540e\u4e00\u540d\u60a3\u8005\u5165\u7ec4\u540e12\u4e2a\u6708\u3002Novocure\u76ee\u524d\u9884\u8ba1LUNAR\u7814\u7a76\u7684\u60a3\u8005\u6700\u540e\u5165\u7ec4\u65f6\u95f4\u4e3a2021\u5e74\u7b2c\u56db\u5b63\u5ea6\uff0c\u6700\u7ec8\u6570\u636e\u5c06\u4e8e2022\u5e74\u63d0\u4ea4\u3002<\/p>\n

2021\u5e744\u6708\uff0c\u57282021\u5e74\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\u7684\u5e74\u4f1a\u4e2d\u8fdb\u884c\u4e8626\u573a\u5173\u4e8e\u80bf\u7624\u7535\u573a\u6cbb\u7597\u7684\u6f14\u793a\uff0c\u8868\u660e\u8be5\u6cbb\u7597\u65b9\u5f0f\u5177\u6709\u5e7f\u9614\u7684\u5e94\u7528\u8303\u56f4\u3002<\/p>\n

2021\u5e744\u6708\u548c5\u6708\uff0c\u518d\u9f0e\u533b\u836f\u5728\u5927\u4e2d\u534e\u533a\u5206\u522b\u542f\u52a8\u80bf\u7624\u7535\u573a\u6cbb\u7597\u7528\u4e8e\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684III\u671f\u5173\u952e\u6027\u7814\u7a76LUNAR\u548c\u7528\u4e8e\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u8111\u8f6c\u79fb\u7684III\u671f\u5173\u952e\u7814\u7a76METIS\u3002<\/p>\n

\u518d\u9f0e\u533b\u836f\u5728\u533b\u9662\u9488\u5bf9\u7231\u666e\u76fe\u5f00\u5c55\u4e86\u5e7f\u6cdb\u7684\u6807\u51c6\u5316\u591a\u5b66\u79d1\u8bca\u7597\u9879\u76ee\u3002<\/p>\n

\u81ea2020\u5e74\u7b2c\u4e09\u5b63\u5ea6\u7231\u666e\u76fe\u5728\u4e2d\u56fd\u5546\u4e1a\u5316\u4e0a\u5e02\u4ee5\u6765\uff0c\u5df2\u88ab\u5217\u516514\u4e2a\u7701\u7ea7\u6216\u5e02\u7ea7\u653f\u5e9c\u6307\u5bfc\u7684\u533a\u57df\u5b9a\u5236\u5546\u4e1a\u5065\u5eb7\u4fdd\u9669\u8ba1\u5212\uff08\u6216\u8865\u5145\u4fdd\u9669\u8ba1\u5212\uff09\u3002<\/p>\n

2021<\/b>\u5e74\u4ea7\u54c1\u9884\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff1a<\/b><\/p>\n

\u5728\u4e2d\u56fd\u63d0\u4ea4\u7528\u4e8e\u6cbb\u7597\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u7684\u4e0a\u5e02\u8bb8\u53ef\u7533\u8bf7\uff08MAA\uff09\u3002 <\/p>\n

\u52a0\u5165\u9488\u5bf9\u5c40\u90e8\u665a\u671f\u80f0\u817a\u764c\u7684PANOVA-3\u5168\u7403III\u671f\u5173\u952e\u7814\u7a76\u3001\u9488\u5bf9\u590d\u53d1\u6027\u5375\u5de2\u764c\u7684INNOVATE-3 III\u671f\u5173\u952e\u7814\u7a76\u3002<\/p>\n

\u5b8c\u6210\u9488\u5bf9\u4e00\u7ebf\u80c3\u817a\u764c\u7684\u4e34\u5e8aII\u671f\u63a2\u7d22\u6027\u7814\u7a76\u5165\u7ec4\u3002<\/p>\n

\u5b8c\u6210\u9488\u5bf9\u590d\u53d1\u6027\u5375\u5de2\u764c\u7684INNOVATE-3 III\u671f\u5173\u952e\u7814\u7a76\u7684\u4e2d\u671f\u5206\u6790\u3002<\/p>\n

\u64ce\u4e50<\/b>®<\/b>\uff08\u745e\u6d3e\u66ff\u5c3c\uff09<\/b><\/p>\n

\u64ce\u4e50\u662f\u4e00\u6b3e\u5f00\u5173\u63a7\u5236\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff0c\u7ecf\u6539\u826f\u4ee5\u5e7f\u6cdb\u6291\u5236\u7a81\u53d8\u7684KIT\u53caPDGFR\u03b1\u6fc0\u9176\uff0c\u662f\u552f\u4e00\u5728\u7f8e\u56fd\u548c\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u6240\u6709\u66fe\u63a5\u53d7\u8fc7\u4e09\u79cd\u6216\u4ee5\u4e0a\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u6cbb\u7597\u7684\u665a\u671f\u80c3\u80a0\u95f4\u8d28\u7624\uff08GIST\uff09\u60a3\u8005\u7684\u7597\u6cd5\u3002<\/p>\n

\u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a<\/b><\/p>\n

2021\u5e747\u6708\uff0c\u64ce\u4e50\u7528\u4e8e\u665a\u671fGIST\u60a3\u8005\u4e8c\u7ebf\u6cbb\u7597\u88ab\u7eb3\u5165\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08CSCO\uff092021\u5e74\u80c3\u80a0\u95f4\u8d28\u7624\u8bca\u65ad\u548c\u6cbb\u7597\u6307\u5357\u3002<\/p>\n

2021\u5e746\u6708\uff0cDeciphera\u516c\u5e03INVICTUS III\u671f\u7814\u7a76\u5173\u4e8eGIST\u60a3\u8005\u4f7f\u7528\u64ce\u4e50\u7684\u5242\u91cf\u9012\u589e\u6570\u636e\u7684\u7ed3\u679c\u3002\u63a2\u7d22\u6027\u5206\u6790\u663e\u793a\uff0c\u5728\u60a3\u8005\u6bcf\u65e5\u4f7f\u7528\u64ce\u4e50150\u6beb\u514b\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u540e\uff0c\u5242\u91cf\u9012\u589e\u81f3150\u6beb\u514b\u3001\u6bcf<\/span>\u65e5\u4e24\u6b21\u540e\u53ef\u80fd\u53ef\u4ee5\u63d0\u4f9b<\/span>\u663e\u8457\u7684\u989d\u5916\u4e34\u5e8a\u83b7\u76ca\uff0c\u5e76\u4e14\u5b89\u5168\u53ef\u8010\u53d7\u3002<\/p>\n

2021\u5e745\u6708\uff0c\u518d\u9f0e\u533b\u836f\u5728\u4e2d\u56fd\u4e0a\u5e02\u64ce\u4e50\uff0c\u8fd9\u662f\u518d\u9f0e\u5728\u8fc7\u53bb16\u4e2a\u6708\u4ee5\u6765\u4e0a\u5e02\u7684\u7b2c\u4e09\u4e2a\u521b\u65b0\u80bf\u7624\u4ea7\u54c1\u3002\u81ea\u64ce\u4e50\u83b7\u6279\u4ee5\u6765\uff0c\u518d\u9f0e\u533b\u836f\u5df2\u7ecf\u5728\u5168\u56fd\u4e3e\u529e\u4e86\u591a\u573a\u4e0a\u5e02\u4f1a\uff0c\u76ee\u524d\u64ce\u4e50\u5df2\u88ab\u7eb3\u5165\u4e86\u4e24\u6b3e\u57ce\u5e02\u666e\u60e0\u9669\u3002<\/p>\n

2021<\/b>\u5e74\u4ea7\u54c1\u9884\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff1a<\/b><\/p>\n

\u7b2c\u56db\u5b63\u5ea6\u83b7\u5f97\u64ce\u4e50\u7528\u4e8eGIST\u4e8c\u7ebf\u6cbb\u7597\u7684INTRIGUE III\u671f\u7814\u7a76\u7684\u4e3b\u8981\u6570\u636e\u3002<\/p>\n

\u9488\u5bf9\u4f0a\u9a6c\u66ff\u5c3c\u96be\u6cbb\u6216\u4e0d\u8010\u53d7\u7684GIST\u60a3\u8005\uff0c\u542f\u52a8\u4e0eMEK\u6291\u5236\u5242binimetinib\u8054\u7528\u7684Ib\/II\u671f\u7814\u7a76\u3002<\/p>\n

Adagrasib<\/b><\/p>\n

Adagrasib\u662f\u4e00\u79cd\u9ad8\u9009\u62e9\u6027\u7684\u5f3a\u6548\u53e3\u670d\u5c0f\u5206\u5b50KRASG12C\u6291\u5236\u5242\uff0c\u7528\u4e8e\u6cbb\u7597KRASG12C\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u3001\u80f0\u817a\u764c\u548c\u5176\u4ed6\u5b9e\u4f53\u7624\u3002<\/p>\n

\u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a<\/b><\/p>\n

2021\u5e746\u6708\uff0c\u518d\u9f0e\u533b\u836f\u7684\u5408\u4f5c\u4f19\u4f34Mirati\u5ba3\u5e03\uff0cFDA\u5df2\u6388\u4e88adagrasib\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff0c\u7528\u4e8e\u6cbb\u7597\u66fe\u63a5\u53d7\u8fc7\u5168\u8eab\u6cbb\u7597\u7684KRASG12C\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u3002<\/p>\n

2021<\/b>\u5e74\u4ea7\u54c1\u9884\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff1a<\/b><\/p>\n

Mirati\u8ba1\u5212\u4e8e2021\u5e74\u4e0b\u534a\u5e74\u516c\u5e03\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u6700\u65b0\u6570\u636e\uff0c\u5e76\u4e8e2021\u5e74\u7b2c\u56db\u5b63\u5ea6\u5728\u7f8e\u56fd\u63d0\u4ea4adagrasib\u53ef\u80fd\u7528\u4e8e\u6cbb\u7597\u66fe\u63a5\u53d7\u8fc7\u5168\u8eab\u6cbb\u7597\u7684KRASG12C\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u3002<\/p>\n

\u8ba1\u5212\u516c\u5e03I\/II\u671fKRYSTAL-01\u7814\u7a76\u7684\u7ed3\u76f4\u80a0\u764c\u6700\u65b0\u6570\u636e\uff0c\u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30adagrasib\u4e0ecetuximab\uff08ERBITUX®\uff09\u8054\u7528\uff0c\u4f5c\u4e3aKRASG12C\u7a81\u53d8\u60a3\u8005\u7684\u4e8c\u7ebf\u6cbb\u7597\u548c\u4f5c\u4e3a\u5355\u836f\u7528\u4e8e\u6cbb\u7597\u66fe\u63a5\u53d7\u4e09\u7ebf\u53ca\u4ee5\u4e0a\u6cbb\u7597\u7684\u60a3\u8005\u7684\u7597\u6548\u3002<\/p>\n

Odronextamab<\/b><\/p>\n

Odronextamab\u662f\u4e00\u6b3e\u53cc\u7279\u5f02\u6027\u5355\u514b\u9686\u6297\u4f53\uff0c\u65e8\u5728\u901a\u8fc7\u8054\u7ed3\u5e76\u6d3b\u5316\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\uff08\u4e0eCD3\u7ed3\u5408\uff09\u53ca\u6dcb\u5df4\u7624\u7ec6\u80de\uff08\u4e0eCD20\u7ed3\u5408\uff09\uff0c\u89e6\u53d1\u6297\u80bf\u7624\u4f5c\u7528\u3002<\/p>\n

\u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a<\/b><\/p>\n

2021\u5e745\u6708\uff0c\u518d\u9f0e\u533b\u836f\u5408\u4f5c\u4f19\u4f34\u518d\u751f\u5143\u91cd\u542f\u4e86\u6f5c\u5728\u5173\u952e\u6027II\u671f\u7814\u7a76\u7684\u6ee4\u6ce1\u6027\u6dcb\u5df4\uff08FL\uff09\u548c\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff08DLBCL\uff09\u60a3\u8005\u5165\u7ec4\u3002<\/p>\n

2021<\/b>\u5e74\u4ea7\u54c1\u9884\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff1a<\/b><\/p>\n

\u5b8c\u6210\u5168\u7403II\u671f\u6f5c\u5728\u5173\u952e\u7814\u7a76\u5728\u5927\u4e2d\u534e\u533a\u7684\u9996\u4f8b\u60a3\u8005\u5165\u7ec4\u3002<\/p>\n

\u5f00\u59cb\u5f00\u53d1\u76ae\u4e0b\u6ce8\u5c04\u5242\u578b\u3002<\/p>\n

Repotrectinib<\/b><\/p>\n

Repotrectinib\u662f\u65b0\u4e00\u4ee3\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08TKI\uff09\uff0c\u80fd\u6709\u6548\u4f5c\u7528\u4e8eROS1\u53caTRK A\/B\/C\uff0c\u5bf9\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7TKI\u6cbb\u7597\u6216TKI\u7ecf\u6cbb\u7684\u60a3\u8005\u5747\u6709\u6cbb\u7597\u6f5c\u529b\u3002<\/p>\n

\u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a<\/b><\/p>\n

2021\u5e745\u6708\uff0c\u518d\u9f0e\u533b\u836f\u5728\u5168\u7403\u6ce8\u518cII\u671fTRIDENT-1\u7814\u7a76\u4e2d\u5b8c\u6210\u5927\u4e2d\u534e\u533a\u9996\u6279\u60a3\u8005\u5165\u7ec4\uff0c\u5305\u62ecROS1\u9633\u6027\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u548cNTRK\u9633\u6027\u665a\u671f\u5b9e\u4f53\u7624\u961f\u5217\u3002<\/p>\n

2021<\/b>\u5e74\u4ea7\u54c1\u9884\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff1a<\/b><\/p>\n

\u5b8c\u6210TRIDENT-1\u7814\u7a76I\u671f\u548cII\u671f\u90e8\u5206\u4e2d50\u540d\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7TKI\u6cbb\u7597\u7684ROS1\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u5165\u7ec4\u3002\u518d\u9f0e\u533b\u836f\u5408\u4f5c\u4f19\u4f34Turning Point Therapeutics\u5ba3\u5e03\uff0c\u9884\u8ba1\u57282022\u5e74\u7b2c\u4e00\u5b63\u5ea6\u53ec\u5f00\u7684FDA\u4f1a\u8bae\u4e0a\u8ba8\u8bba\u8be5\u961f\u5217\u76f2\u6001\u72ec\u7acb\u4e2d\u5fc3\u5ba1\u67e5\uff08BICR\uff09\u4e3b\u8981\u7ed3\u679c\u3002<\/p>\n

\u542f\u52a8TRIDENT-2\u7814\u7a76\uff0c\u4e00\u9879\u9488\u5bf9KRAS\u7a81\u53d8\u5b9e\u4f53\u7624\u7684Ib\/II\u671f\u8054\u7528\u7814\u7a76\u3002<\/p>\n

\u63d0\u4f9b\u6b63\u5728\u8fdb\u884c\u7684TRIDENT-1\u7814\u7a76\u7684\u4e34\u5e8a\u6570\u636e\u66f4\u65b0\u3002<\/p>\n

\u62a5\u544a\u513f\u7ae5\u548c\u5e74\u8f7b\u6210\u4eba\u60a3\u8005I\/II\u671fCARE\u7814\u7a76\u7684\u521d\u59cb\u4e34\u5e8a\u6570\u636e\u3002<\/p>\n

\u9ea6\u7518\u4e50<\/b>™<\/b>\uff08\u9a6c\u5409\u59a5\u6614\u5355\u6297\uff09<\/b><\/p>\n

\u9ea6\u7518\u4e50\u662f\u4e00\u79cd\u9776\u5411\u7528\u4e8e\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532\uff08HER2\uff09\u7684Fc\u6bb5\u4f18\u5316\u7684\u5355\u514b\u9686\u6297\u4f53\u3002<\/p>\n

2021<\/b>\u5e74\u4ea7\u54c1\u9884\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff1a<\/b><\/p>\n

\u4eca\u5e74\u5e74\u5e95\u5de6\u53f3\u5728\u4e2d\u56fd\u9012\u4ea4\u7ecf\u6cbbHER2\u9633\u6027\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u3002<\/p>\n

\u4e8e\u7b2c\u4e09\u5b63\u5ea6\u83b7\u5f97MAHOGANY\u7814\u7a76A\u90e8\u5206\u7684\u521d\u59cb\u6570\u636e\u3002<\/p>\n

\u7b2c\u4e09\u5b63\u5ea6\u5b8c\u6210SOPHIA\u7814\u7a76\u7684\u6700\u7ec8\u603b\u751f\u5b58\u671f\u5206\u6790\uff0cSOPHIA\u662f\u4e00\u9879\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30\u63a5\u53d7\u8fc7HER2\u9776\u5411\u6cbb\u7597\u7684HER2\u9633\u6027\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u4e2d\uff0c\u9a6c\u5409\u59a5\u6614\u5355\u6297\u8054\u5408\u5316\u7597\u5bf9\u6bd4\u66f2\u59a5\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u7684\u7597\u6548\u3002<\/p>\n

Bemarituzumab<\/b><\/p>\n

Bemarituzumab\u662f\u4e00\u6b3e\u540c\u7c7b\u9996\u521b\u6297\u4f53\uff0c\u4f5c\u4e3a\u9488\u5bf9FGFR2b\u8fc7\u5ea6\u8868\u8fbe\u7684\u80bf\u7624\u9776\u5411\u7597\u6cd5\uff0c\u6b63\u5728\u8fdb\u884c\u7528\u4e8e\u6cbb\u7597FGFR2b\u8fc7\u5ea6\u8868\u8fbe\u7684\u80c3\u764c\u53ca\u80c3\u98df\u7ba1\u4ea4\u754c\u5904\u764c\u7684\u7814\u7a76\u3002<\/p>\n

\u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a<\/b><\/p>\n

2021\u5e744\u6708\uff0cFDA\u6388\u4e88\u518d\u9f0e\u533b\u836f\u5408\u4f5c\u4f19\u4f34\u5b89\u8fdb\u516c\u53f8\u6709\u5173Bemarituzumab\u7684\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff0c\u4e0e\u7ecf\u6539\u826fFOLFOX6\uff08\u6c1f\u5627\u5576\u3001\u4e9a\u53f6\u9178\u9499\u548c\u5965\u6c99\u5229\u94c2\uff09\u8054\u7528\u4f5c\u4e3a\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u53d7\u4f532b\uff08FGFR2b\uff09\u8fc7\u5ea6\u8868\u8fbe\u548c\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532\uff08HER2\uff09\u9634\u6027\u7684\u5c40\u90e8\u665a\u671f\u548c\u8f6c\u79fb\u6027\u80c3\u548c\u80c3\u98df\u7ba1\u4ea4\u754c\u5904\uff08GEJ\uff09\u817a\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<\/p>\n

2021<\/b>\u5e74\u4ea7\u54c1\u9884\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff1a<\/b><\/p>\n

\u5728\u56db\u5b63\u5ea6\u542f\u52a8\u9488\u5bf9\u80c3\u764c\u7684\u6ce8\u518c\u6027III\u671f\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n

\u5f00\u5c55\u7528\u4e8e\u5176\u4ed6FGFR2b\u9633\u6027\u7684\u5b9e\u4f53\u7624\uff08\u5305\u62ec\u9cde\u72b6\u7ec6\u80de\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff09\u4e34\u5e8a\u7814\u7a76\u8ba1\u5212\u3002<\/p>\n

CLN-081<\/b><\/p>\n

CLN-081\u662f\u4e00\u79cd\u53e3\u670d\u3001\u5c0f\u5206\u5b50\u3001\u4e0b\u4e00\u4ee3\u3001\u4e0d\u53ef\u9006\u7684\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u6291\u5236\u5242\uff0c\u53ef\u4ee5\u9009\u62e9\u6027\u5730\u9776\u5411\u4f5c\u7528\u4e8eEGFR\u7a81\u53d8\u578b\u7684\u7ec6\u80de\uff0c\u5305\u62ecEGFR\u5916\u663e\u5b5020\u63d2\u5165\u7a81\u53d8\u3002<\/p>\n

\u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a<\/b><\/p>\n

2021\u5e746\u6708\uff0c\u518d\u9f0e\u533b\u836f\u5408\u4f5c\u4f19\u4f34Cullinan\u516c\u5e03CLN-081\u7528\u4e8e\u975e\u5c0f\u7ec6\u80de\u80ba\u764cEGFR\u5916\u663e\u5b5020\u63d2\u5165\u7a81\u53d8\u60a3\u8005\u7684I\/IIa\u671f\u7814\u7a76\u4e2d\u671f\u6570\u636e\u3002CLN-081\u7ee7\u7eed\u8868\u73b0\u51fa\u53ef\u63a5\u53d7\u7684\u603b\u4f53\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u80c3\u80a0\u9053\u6bd2\u6027\u7279\u5f81\u4e5f\u8868\u73b0\u826f\u597d\u3002<\/p>\n

2021<\/b>\u5e74\u4ea7\u54c1\u9884\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff1a<\/b><\/p>\n

\u542f\u52a8\u4e00\u9879\u6f5c\u5728\u6ce8\u518c\u6027IIb\u671f\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n

TPX-0022<\/b><\/p>\n

TPX-0022\u662f\u4e00\u6b3e\u53e3\u670d\u591a\u9776\u70b9\u6fc0\u9176\u6291\u5236\u5242\uff0c\u5177\u6709\u65b0\u578b\u4e09\u7ef4\u5927\u73af\u7ed3\u6784\uff0c\u53ef\u6291\u5236MET\u3001CSF1R\uff08\u96c6\u843d\u523a\u6fc0\u56e0\u5b501\u53d7\u4f53\uff09\u53caSRC\u6fc0\u9176\u3002<\/p>\n

\u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a<\/b><\/p>\n

2021\u5e748\u6708\u548c6\u6708\uff0c\u518d\u9f0e\u533b\u836f\u5408\u4f5c\u4f19\u4f34Turning Point Therapeutics\u7684TPX-0022\u83b7FDA\u6388\u4e88\u5feb\u901f\u901a\u9053\u548c\u5b64\u513f\u836f\u8d44\u683c\uff0c\u7528\u4e8e\u80c3\u764c\u6cbb\u7597\u3002<\/p>\n

2021<\/b>\u5e74\u4ea7\u54c1\u9884\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff1a<\/b><\/p>\n

\u63d0\u4f9bSHIELD-1\u7814\u7a76\u7684I\u671f\u4e34\u5e8a\u5242\u91cf\u63a2\u7d22\u90e8\u5206\u6570\u636e\u66f4\u65b0\uff0c\u5e76\u6839\u636eFDA\u7684\u53cd\u9988\u610f\u89c1\uff0c\u542f\u52a8SHIELD-1\u7814\u7a76\u7684II\u671f\u90e8\u5206\u3002<\/p>\n

\u542f\u52a8\u4e0e\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u9776\u5411\u7597\u6cd5\u8054\u7528\u7684Ib\/II\u671fSHIELD-2\u7814\u7a76\u3002<\/p>\n

Tebotelimab<\/b><\/p>\n

Tebotelimab\u662f\u4e00\u6b3e\u9776\u5411\u4f5c\u7528\u4e8ePD-1\u53caLAG-3\u7684\u5904\u4e8e\u7814\u7a76\u9636\u6bb5\u7684\u3001\u540c\u7c7b\u9996\u521b\u3001\u53cc\u7279\u5f02\u6027\u56db\u4ef7DART\u5206\u5b50\u3002<\/p>\n

\u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a<\/b><\/p>\n

\u518d\u9f0e\u533b\u836f\u5728\u5927\u4e2d\u534e\u533atebotelimab\u4e0e\u5219\u4e50\u8054\u7528\u7684Ib\/II\u671f\u7814\u7a76\u4e2d\u7eb3\u5165\u4e86\u65b0\u7684\u9002\u5e94\u75c7\u30022021\u5e746\u6708\u548c7\u6708\uff0c\u518d\u9f0e\u533b\u836f\u5b8c\u6210\u4e86\u80c6\u7ba1\u764c\u548c\u4e09\u9634\u6027\u4e73\u817a\u764c\u7684\u4e24\u7ec4\u961f\u5217\u7684\u9996\u6279\u60a3\u8005\u5165\u7ec4\u3002<\/p>\n

2021<\/b>\u5e74\u4ea7\u54c1\u9884\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff1a<\/b><\/p>\n

\u66f4\u65b0\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff0c\u5305\u62ec\u672a\u6765\u7684\u7814\u53d1\u8ba1\u5212\u3002<\/p>\n

\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u9886\u57df<\/b><\/p>\n

Efgartigimod<\/b><\/p>\n

Efgartigimod\u662f\u4e00\u79cd\u6297\u4f53\u7247\u65ad\uff0c\u65e8\u5728\u51cf\u5c11\u81f4\u75c5\u514d\u75ab\u7403\u86cb\u767dG\uff08IgG\uff09\u6297\u4f53\u53ca\u963b\u65adIgG\u7684\u5faa\u73af\u5229\u7528\u8fc7\u7a0b\u3002Efgartigimod\u53ef\u4e0e\u65b0\u751f\u513fFc\u53d7\u4f53\uff08FcRn\uff09\u7ed3\u5408\uff0cFcRn\u5728\u5168\u8eab\u4f53\u5185\u5e7f\u6cdb\u8868\u8fbe\u5e76\u5728\u963b\u6b62IgG\u6297\u4f53\u7684\u964d\u89e3\u65b9\u9762\u53d1\u6325\u6838\u5fc3\u4f5c\u7528\u3002<\/p>\n

\u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a<\/b><\/p>\n

2021\u5e747\u6708\uff0c\u518d\u9f0e\u533b\u836f\u5408\u4f5c\u4f19\u4f34argenx\u5ba3\u5e03\u4e86\u5f00\u53d1efgartigimod\u4e24\u9879\u65b0\u9002\u5e94\u75c7\u7684\u8ba1\u5212\uff1a\u808c\u708e\u548c\u5927\u75b1\u6027\u7c7b\u5929\u75b1\u75ae\u3002<\/p>\n

2021\u5e746\u6708\uff0c\u518d\u9f0e\u533b\u836f\u5408\u4f5c\u4f19\u4f34argenx\u5ba3\u5e03\uff0c\u300a\u67f3\u53f6\u5200\u795e\u7ecf\u75c5\u5b66\u300b\u53d1\u8868\u4e86efgartigimod \u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u5168\u8eab\u578b\u91cd\u75c7\u808c\u65e0\u529b\uff08gMG\uff09\u7684\u5173\u952e\u6027III\u671fADAPT\u7814\u7a76\u7684\u7ed3\u679c\u3002<\/p>\n

\u622a\u81f3\u76ee\u524d\uff0c\u4e94\u9879\u4e34\u5e8a\u7814\u7a76\u7533\u8bf7\uff08CTA\uff09\u5df2\u7ecf\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u3002<\/p>\n

2021<\/b>\u5e74\u4ea7\u54c1\u9884\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff1a<\/b><\/p>\n

\u4e0e\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u5546\u8ba8efgartigimod\u6cbb\u7597\u5168\u8eab\u578b\u91cd\u75c7\u808c\u65e0\u529b\u7684\u6f5c\u5728\u52a0\u901f\u6ce8\u518c\u8def\u5f84\u3002<\/p>\n

\u7ee7\u7eed\u4e0eargenx\u5408\u4f5c\uff0c\u63a2\u7d22\u53ca\u63a8\u8fdb\u5176\u4ed6\u9002\u5e94\u75c7\u7684\u4e34\u5e8a\u5f00\u53d1\u3002<\/p>\n

\u5728\u4f7f\u7528\u76ae\u4e0b\u5236\u5242\u9488\u5bf9\u539f\u53d1\u6027\u514d\u75ab\u6027\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\uff08ITP\uff09\u548c\u5bfb\u5e38\u578b\u5929\u75b1\u75ae\uff08PV\uff09\u7684\u5168\u7403III\u671f\u5173\u952e\u7814\u7a76\u4e2d\u5165\u7ec4\u9996\u6279\u5927\u4e2d\u534e\u533a\u60a3\u8005\u3002<\/p>\n

\u6709\u671b\u9012\u4ea4\u5176\u4ed6\u9002\u5e94\u75c7\u7684CTA\u3002<\/p>\n

Efgartigimod\u7528\u4e8e\u6cbb\u7597gMG\u60a3\u8005\u7684\u4e0a\u5e02\u7533\u8bf7\u6709\u671b\u83b7\u5f97FDA\u6279\u51c6\uff08PDUFA\u7684\u836f\u8bc1\u5ba1\u6279\u65f6\u7a0b\u4e3a2021\u5e7412\u670817\u65e5\uff09\u5e76\u4e8e\u5168\u7403\u4e0a\u5e02\u3002<\/p>\n

\u542f\u52a8\u808c\u708e\u548c\u5927\u75b1\u6027\u7c7b\u5929\u75b1\u75ae\u7684\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n

\u6297\u611f\u67d3\u9886\u57df<\/b><\/p>\n

\u7ebd\u518d\u4e50<\/b>®<\/b>\uff08\u7532\u82ef\u78fa\u9178\u5965\u9a6c\u73af\u7d20\uff09<\/b><\/p>\n

\u7ebd\u518d\u4e50\u662f\u4e00\u79cd\u6bcf\u65e5\u4e00\u6b21\u9759\u8109\u6216\u53e3\u670d\u4f7f\u7528\u7684\u6297\u751f\u7d20\uff0c\u7528\u4e8e\u6cbb\u7597CABP\u53caABSSSI\u7684\u6210\u4eba\u60a3\u8005\u3002<\/p>\n

\u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a<\/b><\/p>\n

2021\u5e746\u6708\uff0c\u518d\u9f0e\u533b\u836f\u5408\u4f5c\u4f19\u4f34Paratek Pharmaceuticals\u5ba3\u5e03\uff0c\u7ebd\u518d\u4e50\u53e3\u670d\u7ed9\u836f\u65b9\u6848\u7528\u4e8e\u6cbb\u7597CABP\u6210\u4eba\u60a3\u8005\u7684sNDA\uff0c\u5df2\u83b7\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u7ba1\u7406\u5c40\u6279\u51c6\u3002<\/p>\n

2021<\/b>\u5e74\u4ea7\u54c1\u9884\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff1a<\/b><\/p>\n

\u7ebd\u518d\u4e50\u7528\u4e8e\u6cbb\u7597CABP\u53caABSSSI\u7684\u4e0a\u5e02\u7533\u8bf7\u6709\u671b\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u5e76\u4e0a\u5e02\u3002<\/p>\n

Sulbactam-Durlobactam<\/b>\uff08<\/b>SUL-DUR<\/b>\uff09<\/b><\/p>\n

Sulbactam-Durlobactam\u662f\u4e00\u79cd\u03b2-\u5185\u9170\u80fa\u2571\u03b2-\u5185\u9170\u80fa\u9176\u6291\u5236\u5242\u7684\u7ec4\u5408\u578b\u65b0\u836f\uff0c\u5177\u6709\u72ec\u7279\u7684\u6297\u9c8d\u66fc\u4e0d\u52a8\u6746\u83cc\u7684\u6d3b\u6027\uff0c\u5bf9\u4e8e\u5305\u62ec\u78b3\u9752\u9709\u70ef\u8010\u836f\u83cc\u682a\u5728\u5185\u7684\u7ec6\u83cc\u5177\u6709\u72ec\u7279\u6d3b\u6027\u3002<\/p>\n

\u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a<\/b><\/p>\n

2021\u5e747\u6708\uff0c\u518d\u9f0e\u533b\u836f\u548c\u5176\u5408\u4f5c\u4f19\u4f34Entasis Therapeutics\u5b8c\u6210\u4e86\u5168\u7403ATTACK III\u671f\u6ce8\u518c\u6027\u4e34\u5e8a\u7814\u7a76\u7684\u60a3\u8005\u5165\u7ec4\u3002<\/p>\n

2021<\/b>\u5e74\u4ea7\u54c1\u9884\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff1a<\/b><\/p>\n

\u7b2c\u56db\u5b63\u5ea6\u521d\u53d1\u5e03\u5168\u7403ATTACK III\u671f\u6ce8\u518c\u6027\u4e34\u5e8a\u7814\u7a76\u7684\u521d\u6b65\u5173\u952e\u6570\u636e\u89e3\u8bfb\u3002<\/p>\n

\u62e5\u6709\u5168\u7403\u6743\u76ca\u7684\u4e34\u5e8a\u7814\u7a76\u9879\u76ee<\/b><\/p>\n

ZL-1102<\/b>\uff08<\/b>IL-17<\/b>\u7eb3\u7c73\u6297\u4f53\uff09<\/b><\/p>\n

ZL-1102\u4e3a\u5177\u6709\u9ad8\u4eb2\u548c\u529b\u53ca\u6d3b\u6027\u7684\u9776\u5411IL-17\u65b0\u578b\u4eba\u6e90\u7eb3\u7c73\u6297\u4f53\u3002\u6709\u522b\u4e8e\u5176\u4ed6\u6297IL-17\u4ea7\u54c1\uff0c\u6b63\u5728\u5f00\u53d1\u7684ZL-1102\u5c06\u7528\u4e8e\u6162\u6027\u6591\u5757\u72b6\u94f6\u5c51\u75c5\uff08CPP\uff09\u7684\u5c40\u90e8\u6cbb\u7597\u3002<\/p>\n

2021<\/b>\u5e74\u4ea7\u54c1\u9884\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff1a<\/b><\/p>\n

\u9884\u8ba1\u5c06\u53d1\u5e03\u5168\u7403I\u671f\u7814\u7a76\u7684\u521d\u6b65\u6570\u636e\u89e3\u8bfb\u3002<\/p>\n

ZL-1201 (CD47)<\/b><\/p>\n

ZL-1201\u662f\u4e00\u79cd\u4eba\u6e90\u5316IgG4\u5355\u514b\u9686\u6297\u4f53\uff0c\u7ecf\u6539\u9020\u53ef\u964d\u4f4e\u6548\u5e94\u529f\u80fd\uff0c\u7279\u5f02\u6027\u9776\u5411CD47\u3002\u5176\u6cbb\u7597\u6f5c\u529b\u5c06\u5728\u5b9e\u4f53\u7624\u548c\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u79cd\u8fdb\u884c\u8bc4\u4f30\uff0c\u5305\u62ec\u5355\u4e00\u7597\u6cd5\u548c\u8054\u5408\u7597\u6cd5\u3002<\/p>\n

2021<\/b>\u5e74\u4ea7\u54c1\u9884\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff1a<\/b><\/p>\n

\u5728\u6b63\u5728\u8fdb\u884c\u7684I\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u786e\u5b9a\u63a8\u8350\u7684II\u671f\u5242\u91cf\u3002<\/p>\n

Simurosertib, ZL-2309 (CDC7)<\/b><\/p>\n

Simurosertib\u6216ZL-2309\u662f\u4e00\u6b3e\u53ef\u80fd\u6210\u4e3a\u540c\u7c7b\u9996\u521b\u7684\u53e3\u670d\u3001\u9009\u62e9\u6027CDC7\u6291\u5236\u5242\uff0cCDC7\u662f\u4e00\u79cd\u86cb\u767d\u6fc0\u9176\uff0c\u5728DNA\u590d\u5236\u548c\u7ed5\u8fc7DNA\u635f\u4f24\u53cd\u5e94\u4e2d\u8d77\u5173\u952e\u4f5c\u7528\u3002<\/p>\n

2021<\/b>\u5e74\u4ea7\u54c1\u9884\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff1a<\/b><\/p>\n

\u5e74\u5e95\u524d\u542f\u52a82\u671f\u6982\u5ff5\u9a8c\u8bc1\u6027\u7814\u7a76\u3002<\/p>\n

\u4e1a\u52a1\u62d3\u5c55<\/b><\/p>\n

2021\u5e747\u6708\uff0c\u518d\u9f0e\u533b\u836f\u548cSchrödinger\u5ba3\u5e03\u4e86\u4e00\u9879\u5168\u7403\u7814\u53d1\u548c\u5546\u4e1a\u5316\u5408\u4f5c\u9879\u76ee\uff0c\u4e13\u6ce8\u4e8e\u65b0\u578b\u80bf\u7624DNA\u635f\u4f24\u4fee\u590d\u3002Schrödinger\u5728\u5229\u7528\u8ba1\u7b97\u5e73\u53f0\u52a0\u901f\u836f\u7269\u63a2\u7d22\u65b9\u9762\u662f\u516c\u8ba4\u7684\u9886\u5bfc\u8005\u3002\u8be5\u7814\u7a76\u8ba1\u5212\u5c06\u7531\u4e24\u5bb6\u516c\u53f8\u7684\u79d1\u5b66\u56e2\u961f\u5171\u540c\u5f00\u5c55\u3002\u5728\u9009\u5b9a\u8981\u5f00\u53d1\u7684\u5019\u9009\u836f\u7269\u540e\uff0c\u518d\u9f0e\u533b\u836f\u5c06\u4e3b\u8981\u627f\u62c5\u8be5\u8ba1\u5212\u7684\u5168\u7403\u5f00\u53d1\u3001\u5236\u9020\u548c\u5546\u4e1a\u5316\u3002\u9664\u4e86\u4e0ePARP\u6291\u5236\u5242\u5219\u4e50\u548cZL-2309\u7b49\u73b0\u6709\u518d\u9f0e\u533b\u836f\u4ea7\u54c1\u8fdb\u884c\u6f5c\u5728\u7684\u8054\u7528\u63a2\u7d22\uff0c\u8be5\u9879\u76ee\u8fd8\u5c06\u662f\u518d\u9f0e\u533b\u836f\u5728DNA\u635f\u4f24\u54cd\u5e94\u901a\u8def\u65b9\u9762\u7684\u73b0\u6709\u63a2\u7d22\u5de5\u4f5c\u7684\u6709\u6548\u8865\u5145\u3002<\/p>\n

2021\u5e746\u6708\uff0c\u518d\u9f0e\u533b\u836f\u548cMirati\u5ba3\u5e03\uff0c\u53cc\u65b9\u5c31\u5c0f\u5206\u5b50KRASG12C\u6291\u5236\u5242\u5728\u5927\u4e2d\u534e\u533a\u8fbe\u6210\u5408\u4f5c\u548c\u8bb8\u53ef\u534f\u8bae\u3002\u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0c\u518d\u9f0e\u533b\u836f\u62e5\u6709\u5728\u5927\u4e2d\u534e\u533a\u7814\u7a76\u3001\u5f00\u53d1\u3001\u751f\u4ea7\u53ca\u72ec\u5bb6\u5546\u4e1a\u5316adagrasib\u7684\u6743\u5229\u3002\u518d\u9f0e\u533b\u836f\u5c06\u652f\u6301adagrasib\u7684\u5168\u7403\u6027\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76\uff0c\u4ee5\u52a0\u901fKRASG12C\u7a81\u53d8\u764c\u75c7\u60a3\u8005\u7684\u5165\u7ec4\u3002<\/p>\n

2021\u5e746\u6708\uff0c\u518d\u9f0e\u533b\u836f\u548cMacroGenics\u5ba3\u5e03\u53cc\u65b9\u5c31\u56db\u4e2a\u514d\u75ab\u80bf\u7624\u5206\u5b50\u8fbe\u6210\u72ec\u5bb6\u5408\u4f5c\u548c\u8bb8\u53ef\u534f\u8bae\u3002\u7b2c\u4e00\u4e2a\u5408\u4f5c\u9879\u76ee\u6db5\u76d6\u4e00\u4e2a\u5148\u5bfc\u5206\u5b50\uff0c\u5176\u7ed3\u5408\u4e86MacroGenics\u7684DART\u5e73\u53f0\u3001CD3\u53ca\u4e00\u79cd\u5728\u591a\u79cd\u5b9e\u4f53\u80bf\u7624\u5747\u6709\u8868\u8fbe\u7684\u672a\u62ab\u9732\u9776\u70b9\u7684\u5728\u7814\u5206\u5b50\u3002\u7b2c\u4e8c\u4e2a\u5408\u4f5c\u9879\u76ee\u6d89\u53ca\u5c06\u7531MacroGenics\u9009\u5b9a\u7684\u9776\u70b9\u3002\u518d\u9f0e\u533b\u836f\u5c06\u62e5\u6709\u8fd9\u4e24\u4e2a\u5728\u7814\u5206\u5b50\u5728\u5927\u4e2d\u534e\u533a\u3001\u65e5\u672c\u548c\u97e9\u56fd\u7684\u5546\u4e1a\u5316\u6743\u5229\uff0cMacroGenics\u5219\u62e5\u6709\u5728\u6240\u6709\u5176\u4ed6\u5730\u533a\u7684\u5546\u4e1a\u5316\u6743\u5229\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u518d\u9f0e\u533b\u836f\u8fd8\u83b7\u5f97\u4e86MacroGenics\u53e6\u5916\u4e24\u4e2a\u5728\u7814\u5206\u5b50\u7684\u5168\u7403\u5f00\u53d1\u3001\u751f\u4ea7\u53ca\u5546\u4e1a\u5316\u72ec\u5bb6\u8bb8\u53ef\u3002<\/p>\n

\u516c\u53f8\u6700\u65b0\u52a8\u6001<\/b><\/p>\n

\u518d\u9f0e\u533b\u836f\u8ba1\u5212\u4e8e2021\u5e749\u670822\u65e5\u5728\u7ebf\u4e3e\u529e\u201c<\/span>\u7814\u53d1\u65e5\u201d<\/span>\u6d3b\u52a8\uff0c\u5168\u9762\u4ecb\u7ecd\u516c\u53f8\u4e1a\u52a1\u53ca\u516c\u53f8\u5728\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u548c\u611f\u67d3\u75be\u75c5\u9886\u57df\u65e5\u76ca\u58ee\u5927\u7684\u4ea7\u54c1\u7ba1\u7ebf\u3002\u66f4\u591a\u7ec6\u8282\u4f1a\u7a0d\u540e\u516c\u5e03\u3002<\/p>\n

\u518d\u9f0e\u533b\u836f\u56e2\u961f\u6301\u7eed\u58ee\u5927\u3002\u90e8\u5206\u65b0\u52a0\u5165\u7684\u5458\u5de5\u5305\u62ec\u9ad8\u7ea7\u526f\u603b\u88c1\u517c\u5168\u7403\u4f01\u4e1a\u4f20\u64ad\u8d1f\u8d23\u4ebaDanielle Halstrom\u53ca\u9ad8\u7ea7\u526f\u603b\u88c1\u517c\u5c0f\u5206\u5b50\u751f\u4ea7\u8d1f\u8d23\u4ebaJean Wang\u535a\u58eb\u3002<\/p>\n

\u622a\u81f32021\u5e746\u670830\u65e5\uff0c\u518d\u9f0e\u533b\u836f\u5171\u67091,600\u540d\u5168\u804c\u5458\u5de5\uff0c\u5176\u4e2d\u4ece\u4e8b\u7814\u53d1\u548c\u5546\u4e1a\u5316\u5c97\u4f4d\u7684\u5458\u5de5\u5206\u522b\u4e3a594\u540d\u548c832\u540d\u3002<\/p>\n

\u6211\u4eec\u5c06\u7ee7\u7eed\u6295\u8d44\u4e8e\u5168\u7403\u5404\u5730\u7684\u673a\u6784\u53ca\u8bbe\u65bd\u30029\u6708\uff0c\u6211\u4eec\u4e13\u6ce8\u4e34\u5e8a\u5f00\u53d1\u53ca\u5546\u52a1\u4e8b\u5b9c\u7684\u529e\u516c\u5ba4\u5c06\u5728\u9a6c\u8428\u8bf8\u585e\u5dde\u5251\u6865\u5e02\u5f00\u4e1a\uff0c\u8fd9\u6807\u5fd7\u7740\u6211\u4eec\u6b63\u5f0f\u8fdb\u5165\u4e86\u6ce2\u58eb\u987f\u5730\u533a\u7684\u751f\u7269\u5236\u836f\u751f\u6001\u5708\uff0c\u4ece\u800c\u62d3\u5c55\u6211\u4eec\u5728\u7f8e\u56fd\u7684\u4e1a\u52a1\u8ba1\u5212\u3002\u8fd9\u4e00\u5e03\u5c40\u6269\u5c55\u4e86\u6211\u4eec\u5728\u65e7\u91d1\u5c71\u6e7e\u533a\u4e0d\u65ad\u589e\u957f\u7684\u7814\u53d1\u548c\u4e1a\u52a1\u6d3b\u52a8\u3002<\/p>\n

2021<\/b>\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u8d22\u52a1\u4e1a\u7ee9<\/b><\/p>\n

\u622a\u81f32021\u5e746\u670830\u65e5\u6b62\u4e09\u4e2a\u6708\uff0c\u4ea7\u54c1\u51c0\u6536\u5165\u4e3a3,690\u4e07\u7f8e\u5143\uff0c2020\u5e74\u540c\u671f\u6536\u5165\u4e3a1,100\u4e07\u7f8e\u5143\u3002\u5176\u4e2d\u5305\u62ec\u5219\u4e50\u9500\u552e\u6536\u51652,340\u4e07\u7f8e\u5143\uff082020\u5e74\u540c\u671f\u4e3a750\u4e07\u7f8e\u5143\uff09\uff0c\u7231\u666e\u76fe\u9500\u552e\u6536\u5165950\u4e07\u7f8e\u5143\uff082020\u5e74\u540c\u671f\u4e3a350\u4e07\u7f8e\u5143\uff09\u548c\u64ce\u4e50\u9500\u552e\u6536\u5165400\u4e07\u7f8e\u5143\uff082020\u5e74\u540c\u671f\u65e0\u6536\u5165\uff09\u3002<\/p>\n

\u622a\u81f32021\u5e746\u670830\u65e5\u6b62\u4e09\u4e2a\u6708\u7684\u7814\u53d1\u652f\u51fa\u4e3a1.422\u4ebf\u7f8e\u5143\uff0c2020\u5e74\u540c\u671f\u4e3a6,830\u4e07\u7f8e\u5143\u3002\u7814\u53d1\u5f00\u652f\u7684\u589e\u52a0\u4e3b\u8981\u7531\u4e8e\u652f\u4ed8\u7ed9Mirati\u516c\u53f8\u76846,500\u4e07\u7f8e\u5143\u9884\u4ed8\u6b3e\u548c\u652f\u4ed8\u7ed9MacroGenics\u516c\u53f8\u76842,500\u4e07\u7f8e\u5143\u9884\u4ed8\u6b3e\uff1b\u6b63\u5728\u8fdb\u884c\u53ca\u65b0\u542f\u52a8\u7684\u540e\u671f\u4e34\u5e8a\u7814\u7a76\u7684\u76f8\u5173\u8d39\u7528\uff1b\u589e\u8058\u7814\u53d1\u4eba\u5458\u7684\u5de5\u8d44\u53ca\u5de5\u8d44\u76f8\u5173\u5f00\u652f\u3002<\/p>\n

\u622a\u81f32021\u5e746\u670830\u65e5\u6b62\u4e09\u4e2a\u6708\u7684\u9500\u552e\u3001\u4e00\u822c\u53ca\u884c\u653f\u5f00\u652f\u4e3a5,440\u4e07\u7f8e\u5143\uff0c2020\u5e74\u540c\u671f\u4e3a2,380\u4e07\u7f8e\u5143\u3002\u589e\u52a0\u4e3b\u8981\u7531\u4e8e\u6269\u5927\u7684\u5546\u4e1a\u5316\u56e2\u961f\u7684\u5de5\u8d44\u53ca\u5de5\u8d44\u76f8\u5173\u5f00\u652f\u4ee5\u53ca\u518d\u9f0e\u533b\u836f\u6301\u7eed\u5728\u4e2d\u56fd\u6269\u5c55\u5546\u4e1a\u7ecf\u8425\u7684\u76f8\u5173\u5f00\u652f\u6240\u81f4\u3002<\/p>\n

\u622a\u81f32021\u5e746\u670830\u65e5\u6b62\u4e09\u4e2a\u6708\uff0c\u518d\u9f0e\u533b\u836f\u4e8f\u635f\u51c0\u989d\u4e3a1.633\u4ebf\u7f8e\u5143\uff08\u6216\u666e\u901a\u80a1\u4e1c\u5e94\u5360\u6bcf\u80a1\u4e8f\u635f\u4e3a1.76\u7f8e\u5143\uff09\uff0c2020\u5e74\u540c\u671f\u7684\u4e8f\u635f\u51c0\u989d\u4e3a8,060\u4e07\u7f8e\u5143\uff08\u6216\u666e\u901a\u80a1\u4e1c\u5e94\u5360\u6bcf\u80a1\u4e8f\u635f\u4e3a1.08\u7f8e\u5143\u3002\u4e8f\u635f\u51c0\u989d\u7684\u589e\u52a0\u4e3b\u8981\u7531\u4e8e\u4e0eMirati\u548cMacroGenics\u76f8\u5173\u7684\u65b0\u4e1a\u52a1\u53d1\u5c55\u4ed8\u6b3e\uff0c\u5747\u8bb0\u4e3a\u7814\u53d1\u8d39\u7528\u3002<\/p>\n

\u622a\u81f32021\u5e746\u670830\u65e5\uff0c\u73b0\u91d1\u53ca\u73b0\u91d1\u7b49\u4ef7\u7269\u3001\u77ed\u671f\u6295\u8d44\u53ca\u53d7\u9650\u5236\u8d44\u91d1\u5171\u5408\u8ba1\u4e3a17.673\u4ebf\u7f8e\u5143\uff0c\u800c\u622a\u81f32020\u5e7412\u670831\u65e5\u5219\u4e3a11.875\u4ebf\u7f8e\u5143\u3002<\/p>\n

\u7535\u8bdd\u4f1a\u8bae\u53ca\u7f51\u7edc\u76f4\u64ad\u7684\u4fe1\u606f<\/b><\/p>\n

\u518d\u9f0e\u533b\u836f\u5c06\u4e8e2021\u5e748\u670810\u65e5\u4e0a\u5348\u516b\u65f6\u6b63\uff08\u7f8e\u56fd\u4e1c\u90e8\u65f6\u95f4\uff09\u4e3e\u884c\u73b0\u573a\u7535\u8bdd\u4f1a\u8bae\u53ca\u7f51\u7edc\u76f4\u64ad\u3002\u60a8\u53ef\u6d4f\u89c8\u672c\u516c\u53f8\u7f51\u7ad9http:\/\/ir.zailaboratory.com<\/a>\uff0c\u6536\u770b\u7f51\u4e0a\u76f4\u64ad\u3002\u53c2\u4e0e\u8005\u987b\u4e8e\u7535\u8bdd\u4f1a\u8bae\u524d\u767b\u8bb0\u3002\u8be6\u60c5\u5982\u4e0b\uff1a<\/p>\n

– \u6ce8\u518c\u94fe\u63a5\uff1a <\/p>\n

http:\/\/apac.directeventreg.com\/registration\/event\/7290113<\/a> <\/p>\n

– \u4f1a\u8bae\u7f16\u53f7\uff1a7290113<\/p>\n

\u6240\u6709\u53c2\u4e0e\u8005\u987b\u4e8e\u7535\u8bdd\u4f1a\u8bae\u524d\u4f7f\u7528\u4e0a\u8ff0\u94fe\u63a5\u5b8c\u6210\u7f51\u4e0a\u6ce8\u518c\u7a0b\u5e8f\u3002\u767b\u8bb0\u540e\uff0c\u6bcf\u540d\u53c2\u4e0e\u8005\u5c06\u6536\u5230\u62e8\u5165\u53f7\u7801\u3001\u76f4\u63a5\u6d3b\u52a8\u5bc6\u7801\u53ca\u72ec\u6709\u7684\u63a5\u5165\u5bc6\u7801\uff0c\u4ee5\u4f9b\u7528\u4e8e\u53c2\u4e0e\u7535\u8bdd\u4f1a\u8bae\u3002<\/p>\n

\u91cd\u64ad\u5c06\u4e8e\u7535\u8bdd\u4f1a\u8bae\u540e\u63d0\u4f9b\uff0c\u53ef\u4e8e\u672c\u516c\u53f8\u7f51\u7ad9http:\/\/ir.zailaboratory.com<\/a>\u6d4f\u89c8\u3002<\/p>\n

\u5173\u4e8e\u518d\u9f0e\u533b\u836f<\/b><\/p>\n

\u518d\u9f0e\u533b\u836f\uff08\u7eb3\u65af\u8fbe\u514b\u4ee3\u7801\uff1aZLAB\uff1b\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a9688\uff09\u662f\u4e00\u5bb6\u5904\u4e8e\u5546\u4e1a\u5316\u9636\u6bb5\u7684\u521b\u65b0\u578b\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u4e3a\u4e2d\u56fd\u53ca\u5168\u7403\u7684\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u6027\u53ca\u611f\u67d3\u6027\u75be\u75c5\u60a3\u8005\u63d0\u4f9b\u521b\u65b0\u836f\u7269\u3002\u6211\u4eec\u81f4\u529b\u4e8e\u6ee1\u8db3\u5feb\u901f\u589e\u957f\u7684\u533b\u836f\u5e02\u573a\u6240\u5e26\u6765\u7684\u5de8\u5927\u672a\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u3002\u4e3a\u8fbe\u5230\u8fd9\u4e00\u76ee\u6807\uff0c\u516c\u53f8\u7ecf\u9a8c\u4e30\u5bcc\u7684\u56e2\u961f\u5df2\u4e0e\u5168\u7403\u9886\u5148\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u5efa\u7acb\u4e86\u6218\u7565\u5408\u4f5c\uff0c\u6253\u9020\u8d77\u7531\u521b\u65b0\u836f\u7269\u7ec4\u6210\u7684\u5e7f\u6cdb\u4ea7\u54c1\u7ba1\u7ebf\u3002\u518d\u9f0e\u533b\u836f\u5df2\u5efa\u7acb\u8d77\u5177\u6709\u5f3a\u5927\u836f\u7269\u7814\u53d1\u548c\u8f6c\u5316\u7814\u7a76\u80fd\u529b\u7684\u5185\u90e8\u56e2\u961f\uff0c\u5e76\u5c06\u6253\u9020\u62e5\u6709\u56fd\u9645\u77e5\u8bc6\u4ea7\u6743\u7684\u5019\u9009\u836f\u7269\u7ba1\u7ebf\u3002\u6211\u4eec\u7684\u8fdc\u666f\u662f\u6210\u4e3a\u4e00\u5bb6\u5168\u9762\u6574\u5408\u7684\u521b\u65b0\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u7814\u53d1\u3001\u751f\u4ea7\u5e76\u9500\u552e\u521b\u65b0\u4ea7\u54c1\uff0c\u4e3a\u4fc3\u8fdb\u5168\u4e16\u754c\u4eba\u7c7b\u7684\u5065\u5eb7\u798f\u7949\u800c\u52aa\u529b\u3002<\/p>\n

\u6709\u5173\u516c\u53f8\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95eehttp:\/\/www.zailaboratory.com\/ch\/index.aspx<\/a>\u6216\u5173\u6ce8\u516c\u53f8\u9886\u82f1\u8d26\u53f7\uff1ahttps:\/\/www.linkedin.com\/company\/zai-lab\/<\/a> \u53ca\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a\u518d\u9f0e\u533b\u836f\u3002<\/p>\n

\u76f8\u5173\u94fe\u63a5 :<\/p>\n

http:\/\/ir.zailaboratory.com<\/p>\n","protected":false},"excerpt":{"rendered":"

\u4e0a\u6d77\u548c\u65e7\u91d1\u5c712021\u5e748\u670810\u65e5 \/\u7f8e\u901a\u793e\/ — \u518d\u9f0e\u533b\u836f\uff08\u7eb3\u65af\u8fbe\u514b\u4ee3\u7801\uff1aZLAB\uff1b\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a9688\uff09\u516c\u5e03\u4e862021\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u7684\u8d22\u52a1\u4e1a\u7ee9\uff0c\u4ee5\u53ca\u6700\u8fd1\u7684\u4ea7\u54c1\u4eae\u70b9\u548c\u516c\u53f8\u8fdb\u5c55\u3002 \u518d\u9f0e\u533b\u836f\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u957f\u517c\u9996\u5e2d\u6267\u884c\u5b98\u675c\u83b9\u535a\u58eb\u8868\u793a\uff1a\u201c\u5728\u7b2c\u4e8c\u5b63\u5ea6\uff0c\u518d\u9f0e\u4e00\u5982\u65e2\u5f80\u5feb\u901f\u9ad8\u6548\u5730\u63a8\u8fdb\u5404\u9879\u4e1a\u52a1\u8fdb\u5c55\u3002\u64ce\u4e50\u5728\u4e2d\u56fd\u6210\u529f\u4e0a\u5e02\uff0c\u6210\u4e3a\u518d\u9f0e\u5728\u80c3\u764c\u4ea7\u54c1\u7ba1\u7ebf\u4e2d\u7684\u7b2c\u4e00\u4e2a\u5546\u4e1a\u5316\u4ea7\u54c1\uff0c\u672a\u6765\u518d\u9f0e\u6709\u671b\u5efa\u7acb\u8d77\u4e16\u754c\u9886\u5148\u7684\u80c3\u764c\u7ba1\u7ebf\u3002\u5219\u4e50\u548c\u7231\u666e\u76fe\u8d21\u732e\u4e86\u5f3a\u52b2\u7684\u6536\u5165\u589e\u957f\uff1b\u6211\u4eec\u4e0eMirati\u3001MacroGenics\u548cSchrödinger\u8fbe\u6210\u6218\u7565\u5408\u4f5c\uff0c\u8fdb\u4e00\u6b65\u52a0\u5f3a\u4e86\u6211\u4eec\u5728\u80bf\u7624\u65b9\u9762\u7684\u5b9e\u529b\u53ca\u5168\u7403\u7ba1\u7ebf\u3002 2021\u5e74\uff0c\u6211\u4eec\u7684\u4ea7\u54c1\u7ba1\u7ebf\u4ecd\u6709\u8bb8\u591a\u503c\u5f97\u671f\u5f85\u7684\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff0c\u5305\u62ec\u7ebd\u518d\u4e50\u6709\u671b\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u793e\u533a\u83b7\u5f97\u6027\u7ec6\u83cc\u6027\u80ba\u708e\uff08CABP\uff09\u548c\u6025\u6027\u7ec6\u83cc\u6027\u76ae\u80a4\u548c\u76ae\u80a4\u7ed3\u6784\u611f\u67d3\uff08ABSSSI\uff09\u3002\u6211\u4eec\u4f1a\u7ee7\u7eed\u63a8\u8fdb\u4ea7\u54c1\u7684\u6ce8\u518c\uff0c\u5e76\u9884\u8ba1\u4e8e\u8fd1\u671f\u5411\u4e3b\u7ba1\u90e8\u95e8\u54a8\u8be2efgartigimod\u6ce8\u518c\u76f8\u5173\u5de5\u4f5c\u3002\u6b64\u5916\uff0c\u6211\u4eec\u9884\u8ba1\u4eca\u5e74\u8fd8\u4f1a\u6709\u8bb8\u591a\u91cd\u8981\u7684\u6570\u636e\u516c\u5e03\u548c\u66f4\u65b0\uff0c\u5305\u62ec\uff1a\u80bf\u7624\u7535\u573a\u6cbb\u7597\u7528\u4e8e\u5375\u5de2\u764c\u7684\u6cbb\u7597\u3001\u64ce\u4e50\u7528\u4e8e\u80c3\u80a0\u95f4\u8d28\u7624\u7684\u4e8c\u7ebf\u6cbb\u7597\u3001margetuximab\u7528\u4e8e\u80c3\u764c\u7684\u6cbb\u7597\u3001CLN-081\u7528\u4e8e\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u6cbb\u7597\u3001TPX-0022\u7528\u4e8e\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u548c\u80c3\u764c\u7684\u6cbb\u7597\u3001adagrasib\u7528\u4e8e\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u548c\u7ed3\u76f4\u80a0\u764c\u7684\u6cbb\u7597\uff0c\u4ee5\u53ca\u6211\u4eec\u5176\u4ed6\u62e5\u6709\u5168\u7403\u6743\u76ca\u7684\u5728\u7814\u4ea7\u54c1\u3002 \u6211\u4eec\u6bd4\u4ee5\u5f80\u4efb\u4f55\u65f6\u5019\u90fd\u66f4\u52a0\u4e13\u6ce8\u4e8e\u6211\u4eec\u7684\u4f7f\u547d\uff1a\u5efa\u7acb\u4e00\u5bb6\u5168\u7403\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u516c\u53f8\uff0c\u4ee5\u6ee1\u8db3\u4e2d\u56fd\u548c\u4e16\u754c\u5404\u5730\u60a3\u8005\u4e9f\u9700\u7684\u533b\u7597\u9700\u6c42\u3002\u201d \u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\u53ca\u9884\u671f\u7684\u91cc\u7a0b\u7891 \u80bf\u7624\u9886\u57df \u5219\u4e50®\uff08\u5c3c\u62c9\u5e15\u5229\uff09 \u5219\u4e50\u662f\u4e00\u79cd\u53e3\u670d\u3001\u6bcf\u65e5\u4e00\u6b21\u7684\u5c0f\u5206\u5b50\u805a\uff08ADP-\u6838\u7cd6\uff09PARP 1\/2\u6291\u5236\u5242\uff0c\u662f\u552f\u4e00\u5728\u7f8e\u56fd\u3001\u6b27\u6d32\u548c\u4e2d\u56fd\u5185\u5730\uff08\u4ee5\u4e0b\u7b80\u79f0\u201c\u4e2d\u56fd\u201d\uff09\u83b7\u6279\u7684\u65e0\u8bba\u60a3\u8005\u751f\u7269\u6807\u8bb0\u7269\u72b6\u6001\u5982\u4f55\uff0c\u5747\u53ef\u5355\u836f\u7528\u4e8e\u5bf9\u542b\u94c2\u5316\u7597\u5b8c\u5168\u6216\u90e8\u5206\u7f13\u89e3\u7684\u665a\u671f\u4e0a\u76ae\u6027\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6216\u539f\u53d1\u6027\u8179\u819c\u60a3\u8005\u7ef4\u6301\u6027\u6cbb\u7597\u7684PARP\u6291\u5236\u5242\u3002 \u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a \u518d\u9f0e\u533b\u836f\u8fd1\u51e0\u4e2a\u6708\u5728\u5219\u4e50\u8fdb\u9662\u65b9\u9762\u53d6\u5f97\u4e86\u957f\u8db3\u8fdb\u5c55\u3002\u4e8e2021\u5e743\u67081\u65e5\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f55\uff08NRDL\uff09\u5b9e\u65bd\u5f53\u65e5\u81f32021\u5e746\u670830\u65e5\u7684\u671f\u95f4\uff0c\u5219\u4e50\u7684\u8fdb\u9662\u6570\u91cf\u4e3a\u4e4b\u524d7\u500d\uff0c\u8fbe\u5230800\u4f59\u5bb6\u3002 2021\u5e74\u4ea7\u54c1\u9884\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff1a \u5b8c\u6210\u5219\u4e50\u8054\u5408tebotelimab\u7528\u4e8e\u80c3\u764c\u76841b\u671f\u4e34\u5e8a\u7814\u7a76\u7684\u60a3\u8005\u5165\u7ec4\u3002 \u516c\u5e03\u5219\u4e50\u7528\u4e8e\u4e2d\u56fd\u5375\u5de2\u764c\u60a3\u8005\u4e00\u7ebf\u7ef4\u6301\u6cbb\u7597\u7684III\u671f\u4e34\u5e8a\u7814\u7a76PRIME\u7684\u4e3b\u8981\u7ed3\u679c\u3002 \u4e89\u53d6\u5375\u5de2\u764c\u4e00\u7ebf\u9002\u5e94\u75c7\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f55\u3002 \u7ee7\u7eed\u63a2\u7d22\u5176\u4ed6\u9002\u5e94\u75c7\u53ca\u4e0e\u5176\u4ed6\u836f\u7269\u8054\u7528\u7684\u673a\u4f1a\u3002 \u80bf\u7624\u7535\u573a\u6cbb\u7597 \u80bf\u7624\u7535\u573a\u6cbb\u7597\u662f\u4e00\u79cd\u5229\u7528\u7279\u5b9a\u7535\u573a\u9891\u7387\u5e72\u6270\u7ec6\u80de\u5206\u88c2\u7684\u7597\u6cd5\u3002 \u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a 2021\u5e747\u6708\uff0c\u518d\u9f0e\u533b\u836f\u5408\u4f5c\u4f19\u4f34Novocure\u516c\u5e03\u4e86II\u671f\u809d\u764c\u63a2\u7d22\u6027\u7814\u7a76HEPANOVA\u7814\u7a76\u7684\u6700\u7ec8\u7ed3\u679c\uff0c\u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30\u80bf\u7624\u7535\u573a\u6cbb\u7597\u8054\u5408\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u665a\u671f\u809d\u764c\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u572821\u540d\u53ef\u8bc4\u4f30\u7684\u60a3\u8005\u4e2d\uff0cHEPANOVA\u663e\u793a\u7684\u75be\u75c5\u63a7\u5236\u7387\u4e3a76%\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\u4e3a9.5%\uff0c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e3a5.8\u4e2a\u6708\uff0c\u8fd9\u4e9b\u60a3\u8005\u5747\u9884\u540e\u4e0d\u826f\u5e76\u5bf9\u836f\u7269\u6cbb\u7597\u66b4\u9732\u6709\u9650\u3002\u5728\u63a5\u53d7\u81f3\u5c1112\u5468\uff08n=11\uff09\u80bf\u7624\u7535\u573a\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u75be\u75c5\u63a7\u5236\u7387\u4e3a91%\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\u4e3a18%\u3002Novocure\u6b63\u79ef\u6781\u8bbe\u8ba1III\u671f\u5173\u952e\u6027\u7814\u7a76\uff0c\u8ba1\u5212\u5c06\u80bf\u7624\u7535\u573a\u6cbb\u7597\u4e0e\u73b0\u884c\u7684\u5e38\u89c4\u6cbb\u7597\uff08\u5305\u62ec\u514d\u75ab\u6cbb\u7597\uff09\u8054\u7528\u3002 2021\u5e745\u6708\uff0c\u518d\u9f0e\u533b\u836f\u5408\u4f5c\u4f19\u4f34Novocure\u5ba3\u5e03\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u4e86\u5176\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u8fdb\u884c\u7684III\u671f\u5173\u952e\u7814\u7a76LUNAR\u7684\u5668\u68b0\u8c41\u514d\u7814\u7a76\uff08IDE\uff09\u8865\u5145\u6750\u6599\uff0c\u5176\u4e2d\u7eb3\u5165\u4e86\u72ec\u7acb\u6570\u636e\u76d1\u7763\u59d4\u5458\u4f1a\u5efa\u8bae\u7684\u7814\u7a76\u65b9\u6848\u53d8\u66f4\uff0c\u5c06\u5165\u7ec4\u8981\u6c42\u964d\u4f4e\u81f3276\u540d\u60a3\u8005\uff0c\u968f\u8bbf\u65f6\u95f4\u7f29\u77ed\u81f3\u6700\u540e\u4e00\u540d\u60a3\u8005\u5165\u7ec4\u540e12\u4e2a\u6708\u3002Novocure\u76ee\u524d\u9884\u8ba1LUNAR\u7814\u7a76\u7684\u60a3\u8005\u6700\u540e\u5165\u7ec4\u65f6\u95f4\u4e3a2021\u5e74\u7b2c\u56db\u5b63\u5ea6\uff0c\u6700\u7ec8\u6570\u636e\u5c06\u4e8e2022\u5e74\u63d0\u4ea4\u3002 2021\u5e744\u6708\uff0c\u57282021\u5e74\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\u7684\u5e74\u4f1a\u4e2d\u8fdb\u884c\u4e8626\u573a\u5173\u4e8e\u80bf\u7624\u7535\u573a\u6cbb\u7597\u7684\u6f14\u793a\uff0c\u8868\u660e\u8be5\u6cbb\u7597\u65b9\u5f0f\u5177\u6709\u5e7f\u9614\u7684\u5e94\u7528\u8303\u56f4\u3002 2021\u5e744\u6708\u548c5\u6708\uff0c\u518d\u9f0e\u533b\u836f\u5728\u5927\u4e2d\u534e\u533a\u5206\u522b\u542f\u52a8\u80bf\u7624\u7535\u573a\u6cbb\u7597\u7528\u4e8e\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684III\u671f\u5173\u952e\u6027\u7814\u7a76LUNAR\u548c\u7528\u4e8e\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u8111\u8f6c\u79fb\u7684III\u671f\u5173\u952e\u7814\u7a76METIS\u3002 \u518d\u9f0e\u533b\u836f\u5728\u533b\u9662\u9488\u5bf9\u7231\u666e\u76fe\u5f00\u5c55\u4e86\u5e7f\u6cdb\u7684\u6807\u51c6\u5316\u591a\u5b66\u79d1\u8bca\u7597\u9879\u76ee\u3002 \u81ea2020\u5e74\u7b2c\u4e09\u5b63\u5ea6\u7231\u666e\u76fe\u5728\u4e2d\u56fd\u5546\u4e1a\u5316\u4e0a\u5e02\u4ee5\u6765\uff0c\u5df2\u88ab\u5217\u516514\u4e2a\u7701\u7ea7\u6216\u5e02\u7ea7\u653f\u5e9c\u6307\u5bfc\u7684\u533a\u57df\u5b9a\u5236\u5546\u4e1a\u5065\u5eb7\u4fdd\u9669\u8ba1\u5212\uff08\u6216\u8865\u5145\u4fdd\u9669\u8ba1\u5212\uff09\u3002 2021\u5e74\u4ea7\u54c1\u9884\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff1a \u5728\u4e2d\u56fd\u63d0\u4ea4\u7528\u4e8e\u6cbb\u7597\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u7684\u4e0a\u5e02\u8bb8\u53ef\u7533\u8bf7\uff08MAA\uff09\u3002  \u52a0\u5165\u9488\u5bf9\u5c40\u90e8\u665a\u671f\u80f0\u817a\u764c\u7684PANOVA-3\u5168\u7403III\u671f\u5173\u952e\u7814\u7a76\u3001\u9488\u5bf9\u590d\u53d1\u6027\u5375\u5de2\u764c\u7684INNOVATE-3 III\u671f\u5173\u952e\u7814\u7a76\u3002 \u5b8c\u6210\u9488\u5bf9\u4e00\u7ebf\u80c3\u817a\u764c\u7684\u4e34\u5e8aII\u671f\u63a2\u7d22\u6027\u7814\u7a76\u5165\u7ec4\u3002 \u5b8c\u6210\u9488\u5bf9\u590d\u53d1\u6027\u5375\u5de2\u764c\u7684INNOVATE-3 III\u671f\u5173\u952e\u7814\u7a76\u7684\u4e2d\u671f\u5206\u6790\u3002 \u64ce\u4e50®\uff08\u745e\u6d3e\u66ff\u5c3c\uff09 \u64ce\u4e50\u662f\u4e00\u6b3e\u5f00\u5173\u63a7\u5236\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff0c\u7ecf\u6539\u826f\u4ee5\u5e7f\u6cdb\u6291\u5236\u7a81\u53d8\u7684KIT\u53caPDGFR\u03b1\u6fc0\u9176\uff0c\u662f\u552f\u4e00\u5728\u7f8e\u56fd\u548c\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u6240\u6709\u66fe\u63a5\u53d7\u8fc7\u4e09\u79cd\u6216\u4ee5\u4e0a\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u6cbb\u7597\u7684\u665a\u671f\u80c3\u80a0\u95f4\u8d28\u7624\uff08GIST\uff09\u60a3\u8005\u7684\u7597\u6cd5\u3002 \u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a 2021\u5e747\u6708\uff0c\u64ce\u4e50\u7528\u4e8e\u665a\u671fGIST\u60a3\u8005\u4e8c\u7ebf\u6cbb\u7597\u88ab\u7eb3\u5165\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08CSCO\uff092021\u5e74\u80c3\u80a0\u95f4\u8d28\u7624\u8bca\u65ad\u548c\u6cbb\u7597\u6307\u5357\u3002 2021\u5e746\u6708\uff0cDeciphera\u516c\u5e03INVICTUS III\u671f\u7814\u7a76\u5173\u4e8eGIST\u60a3\u8005\u4f7f\u7528\u64ce\u4e50\u7684\u5242\u91cf\u9012\u589e\u6570\u636e\u7684\u7ed3\u679c\u3002\u63a2\u7d22\u6027\u5206\u6790\u663e\u793a\uff0c\u5728\u60a3\u8005\u6bcf\u65e5\u4f7f\u7528\u64ce\u4e50150\u6beb\u514b\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u540e\uff0c\u5242\u91cf\u9012\u589e\u81f3150\u6beb\u514b\u3001\u6bcf\u65e5\u4e24\u6b21\u540e\u53ef\u80fd\u53ef\u4ee5\u63d0\u4f9b\u663e\u8457\u7684\u989d\u5916\u4e34\u5e8a\u83b7\u76ca\uff0c\u5e76\u4e14\u5b89\u5168\u53ef\u8010\u53d7\u3002 2021\u5e745\u6708\uff0c\u518d\u9f0e\u533b\u836f\u5728\u4e2d\u56fd\u4e0a\u5e02\u64ce\u4e50\uff0c\u8fd9\u662f\u518d\u9f0e\u5728\u8fc7\u53bb16\u4e2a\u6708\u4ee5\u6765\u4e0a\u5e02\u7684\u7b2c\u4e09\u4e2a\u521b\u65b0\u80bf\u7624\u4ea7\u54c1\u3002\u81ea\u64ce\u4e50\u83b7\u6279\u4ee5\u6765\uff0c\u518d\u9f0e\u533b\u836f\u5df2\u7ecf\u5728\u5168\u56fd\u4e3e\u529e\u4e86\u591a\u573a\u4e0a\u5e02\u4f1a\uff0c\u76ee\u524d\u64ce\u4e50\u5df2\u88ab\u7eb3\u5165\u4e86\u4e24\u6b3e\u57ce\u5e02\u666e\u60e0\u9669\u3002 2021\u5e74\u4ea7\u54c1\u9884\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff1a \u7b2c\u56db\u5b63\u5ea6\u83b7\u5f97\u64ce\u4e50\u7528\u4e8eGIST\u4e8c\u7ebf\u6cbb\u7597\u7684INTRIGUE III\u671f\u7814\u7a76\u7684\u4e3b\u8981\u6570\u636e\u3002 \u9488\u5bf9\u4f0a\u9a6c\u66ff\u5c3c\u96be\u6cbb\u6216\u4e0d\u8010\u53d7\u7684GIST\u60a3\u8005\uff0c\u542f\u52a8\u4e0eMEK\u6291\u5236\u5242binimetinib\u8054\u7528\u7684Ib\/II\u671f\u7814\u7a76\u3002 Adagrasib Adagrasib\u662f\u4e00\u79cd\u9ad8\u9009\u62e9\u6027\u7684\u5f3a\u6548\u53e3\u670d\u5c0f\u5206\u5b50KRASG12C\u6291\u5236\u5242\uff0c\u7528\u4e8e\u6cbb\u7597KRASG12C\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u3001\u80f0\u817a\u764c\u548c\u5176\u4ed6\u5b9e\u4f53\u7624\u3002 \u8fd1\u671f\u4ea7\u54c1\u4eae\u70b9\uff1a 2021\u5e746\u6708\uff0c\u518d\u9f0e\u533b\u836f\u7684\u5408\u4f5c\u4f19\u4f34Mirati\u5ba3\u5e03\uff0cFDA\u5df2\u6388\u4e88adagrasib\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff0c\u7528\u4e8e\u6cbb\u7597\u66fe\u63a5\u53d7\u8fc7\u5168\u8eab\u6cbb\u7597\u7684KRASG12C\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u3002 2021\u5e74\u4ea7\u54c1\u9884\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6\uff1a Mirati\u8ba1\u5212\u4e8e2021\u5e74\u4e0b\u534a\u5e74\u516c\u5e03\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u6700\u65b0\u6570\u636e\uff0c\u5e76\u4e8e2021\u5e74\u7b2c\u56db\u5b63\u5ea6\u5728\u7f8e\u56fd\u63d0\u4ea4adagrasib\u53ef\u80fd\u7528\u4e8e\u6cbb\u7597\u66fe\u63a5\u53d7\u8fc7\u5168\u8eab\u6cbb\u7597\u7684KRASG12C\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u3002 \u8ba1\u5212\u516c\u5e03I\/II\u671fKRYSTAL-01\u7814\u7a76\u7684\u7ed3\u76f4\u80a0\u764c\u6700\u65b0\u6570\u636e\uff0c\u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30adagrasib\u4e0ecetuximab\uff08ERBITUX®\uff09\u8054\u7528\uff0c\u4f5c\u4e3aKRASG12C\u7a81\u53d8\u60a3\u8005\u7684\u4e8c\u7ebf\u6cbb\u7597\u548c\u4f5c\u4e3a\u5355\u836f\u7528\u4e8e\u6cbb\u7597\u66fe\u63a5\u53d7\u4e09\u7ebf\u53ca\u4ee5\u4e0a\u6cbb\u7597\u7684\u60a3\u8005\u7684\u7597\u6548\u3002 Odronextamab Odronextamab\u662f\u4e00\u6b3e\u53cc\u7279\u5f02\u6027\u5355\u514b\u9686\u6297\u4f53\uff0c\u65e8\u5728\u901a\u8fc7\u8054\u7ed3\u5e76\u6d3b\u5316\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\uff08\u4e0eCD3\u7ed3\u5408\uff09\u53ca\u6dcb\u5df4\u7624\u7ec6\u80de\uff08\u4e0eCD20\u7ed3\u5408\uff09\uff0c\u89e6\u53d1\u6297\u80bf\u7624\u4f5c\u7528\u3002… Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":8278,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-40654","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/40654","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=40654"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/40654\/revisions"}],"predecessor-version":[{"id":40655,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/40654\/revisions\/40655"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/8278"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=40654"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=40654"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=40654"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}