{"id":40464,"date":"2021-08-09T07:00:00","date_gmt":"2021-08-09T00:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021080907000040464"},"modified":"2021-08-09T21:37:24","modified_gmt":"2021-08-09T13:37:24","slug":"%e5%92%8c%e9%bb%84%e5%8c%bb%e8%8d%af%e4%b8%8eepizyme%e5%90%88%e4%bd%9c%e5%9c%a8%e5%a4%a7%e4%b8%ad%e5%8d%8e%e5%8c%ba%e8%bf%9b%e8%a1%8ctazverik%e7%9a%84%e5%bc%80%e5%8f%91%e5%92%8c%e5%95%86","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021080907000040464","title":{"rendered":"\u548c\u9ec4\u533b\u836f\u4e0eEpizyme\u5408\u4f5c\u5728\u5927\u4e2d\u534e\u533a\u8fdb\u884cTAZVERIK\u00ae\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316"},"content":{"rendered":"<p><p><b>&#8211;&nbsp; <\/b>\u662f\u6b21\u5408\u4f5c\u65e8\u5728\u4fc3\u8fdb TAZVERIK<sup>&reg; <\/sup>\u7684\u5168\u7403\u5f00\u53d1\uff0c\u4ee5\u53ca\u4e0e\u548c\u9ec4\u533b\u836f\u521b\u65b0\u80bf\u7624\u836f\u7269\u7684\u8054\u5408\u7597\u6cd5\u7814\u7a76 &nbsp;&#8211;<\/p>\n<p class=\"prntac\">&#8211;&nbsp; Epizyme \u5c06\u6536\u53d62,500\u4e07\u7f8e\u5143\u7684\u9996\u671f\u4ed8\u6b3e\u53ca\u4e0d\u8d85\u8fc72.85\u4ebf\u7f8e\u5143\u7684\u6f5c\u5728\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c<br \/>\u518d\u52a0\u4e0a\u989d\u5916\u7684\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\uff1b\u548c\u9ec4\u533b\u836f\u5c06\u53d6\u5f97\u5728\u5927\u4e2d\u534e\u533a\u5f00\u53d1\u53ca\u5546\u4e1a\u5316 TAZVERIK<sup>&reg; <\/sup>\u7684\u6743\u5229 &nbsp;&#8211;<\/p>\n<p class=\"prntac\">&#8211;&nbsp; \u548c\u9ec4\u533b\u836f\u5c06\u4e8e8\u67089\u65e5\uff08\u661f\u671f\u4e00\uff09\u4e0a\u53489\u65f630\u5206\uff08\u4e1c\u90e8\u590f\u4ee4\u65f6\u95f4\uff09\/\u4e0b\u53482\u65f630\u5206\uff08\u683c\u6797\u5c3c\u6cbb\u65f6\u95f4\uff09&nbsp;\/ \u665a\u4e0a9\u65f630\u5206\uff08\u9999\u6e2f\u65f6\u95f4\uff09\u4e3e\u884c\u7535\u8bdd\u4f1a\u8bae\u5e76\u540c\u6b65\u7f51\u7edc\u76f4\u64ad\u3002\u8be6\u60c5\u8bf7\u6d4f\u89c8 <a target=\"_blank\" href=\"http:\/\/www.hutch-med.com\/event\" rel=\"nofollow noopener\">www.hutch-med.com\/event<\/a>&nbsp;\u67e5\u770b &#8211;<\/p>\n<p><span id=\"spanHghltc17a\">\u4e2d\u56fd\u9999\u6e2f\u548c\u7f8e\u56fd\u9a6c\u8428\u8bf8\u585e\u5dde\u5251\u6865<\/span>2021\u5e748\u67089\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u548c\u9ec4\u533b\u836f\uff08\u4e2d\u56fd\uff09\u6709\u9650\u516c\u53f8\uff08\u7b80\u79f0\u201c\u548c\u9ec4\u533b\u836f\u201d\u6216\u201cHUTCHMED\u201d\uff09\uff08\u7eb3\u65af\u8fbe\u514b\/\u4f26\u6566\u8bc1\u4ea4\u6240\uff1aHCM\uff1b\u9999\u6e2f\u4ea4\u6613\u6240\uff1a13\uff09\u4e0e Epizyme, Inc.\uff08\u7b80\u79f0\u201cEpizyme\u201d\uff09\uff08\u7eb3\u65af\u8fbe\u514b\uff1a EPZM\uff09\uff08\u4e00\u5bb6\u5904\u4e8e\u5546\u4e1a\u9636\u6bb5\u7684\u5168\u9762\u4e00\u4f53\u5316\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1\u53ca\u63d0\u4f9b\u521b\u65b0\u7684\u8868\u89c2\u9057\u4f20\u5b66\u7597\u6cd5\uff09\u4eca\u65e5\u5ba3\u5e03\u5f00\u5c55\u5408\u4f5c\uff0c\u5728\u5927\u4e2d\u534e\u533a\uff08\u5305\u62ec\u4e2d\u56fd\u5927\u9646\u3001\u9999\u6e2f\u3001\u6fb3\u95e8\u548c\u53f0\u6e7e<span id=\"spanHghlt6c35\">\uff09\uff08\u4ee5\u4e0b\u7b80\u79f0<\/span>\u201c\u5730\u57df\u201d\uff09\u8fdb\u884c TAZVERIK<sup>&reg; <\/sup>\u7684\u7814\u7a76\u3001\u5f00\u53d1\u3001\u751f\u4ea7\u4ee5\u53ca\u5546\u4e1a\u5316\u3002<\/p>\n<p>TAZVERIK<sup>&reg; <\/sup>\u662f\u7531 Epizyme \u5f00\u53d1\u7684 EZH2\u7532\u57fa\u8f6c\u79fb\u9176\u6291\u5236\u5242\uff0c\u5df2\u83b7\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08\u201cFDA\u201d\uff09\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u67d0\u4e9b\u4e0a\u76ae\u6837\u8089\u7624\uff08ES\uff09\u60a3\u8005\u548c\u67d0\u4e9b\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\uff08FL\uff09\u7684\u60a3\u8005\u3002\u57fa\u4e8e\u5176\u6cbb\u7597\u4e0a\u76ae\u6837\u8089\u7624\u548c\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08\u201cORR\u201d\uff09\u548c\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08\u201cDOR\u201d\uff09\uff0cTAZVERIK<sup>&reg; <\/sup>\u5df2\u5206\u522b\u4e8e2020\u5e741\u6708\u548c6\u6708\u83b7 FDA \u52a0\u901f\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u4e0a\u76ae\u6837\u8089\u7624\u548c\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u3002<\/p>\n<p>Epizyme \u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98 <span class=\"xn-person\">Robert Bazemore<\/span> \u5148\u751f\u8868\u793a\uff1a\u201c\u6211\u4eec\u5f88\u9ad8\u5174\u80fd\u591f\u542f\u52a8\u8fd9\u9879\u5408\u4f5c\uff0c\u5e2e\u52a9\u5c06 &nbsp;TAZVERIK<sup>&reg; <\/sup>\u5e26\u7ed9\u5927\u4e2d\u534e\u533a\u5185\u60a3\u8005\uff0c\u5e76\u8ba9\u548c\u9ec4\u533b\u836f\u53c2\u4e0e\u5230 TAZVERIK<sup>&reg; <\/sup>\u7684\u5168\u7403\u5f00\u53d1\u4e2d\u3002\u548c\u9ec4\u533b\u836f\u62e5\u6709\u4e30\u5bcc\u4e34\u5e8a\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u7ecf\u9a8c\uff0c\u5e76\u5171\u540c\u81f4\u529b\u4e8e\u900f\u8fc7\u66f4\u591a\u4e34\u5e8a\u8bd5\u9a8c\u4ee5\u6269\u5927 TAZVERIK<sup>&reg; <\/sup>\u7684\u4ef7\u503c\uff0c\u800c\u8fd9\u4e0e Epizyme \u7684\u5f00\u53d1\u8ba1\u5212\u76f8\u8f85\u76f8\u627f\u3002\u56e0\u6b64\u5bf9\u6211\u4eec\u800c\u8a00\uff0c\u548c\u9ec4\u533b\u836f\u662f\u6211\u4eec\u5728\u5927\u4e2d\u534e\u533a\u7684\u7406\u60f3\u5408\u4f5c\u4f19\u4f34\u3002\u201dBazemore\u5148\u751f\u8fdb\u4e00\u6b65\u8868\u793a\uff1a\u201c\u900f\u8fc7\u662f\u6b21\u7684\u5408\u4f5c\uff0c\u6211\u4eec\u9884\u8ba1 TAZVERIK<sup>&reg;<\/sup>\u5c06\u6210\u4e3a\u9996\u4e2a\u5f15\u5165\u5927\u4e2d\u534e\u533a\u5e02\u573a\u7684 EZH2\u6291\u5236\u5242\u3002\u6211\u4eec\u6df1\u4fe1\uff0c\u548c\u9ec4\u533b\u836f\u53c2\u4e0e TAZVERIK<sup>&reg; <\/sup>\u7684\u5168\u7403\u5f00\u53d1\uff0c\u6709\u52a9\u4e8e\u4e3a TAZVERIK<sup>&reg; <\/sup>\u4e0e R2\u65b9\u6848\uff08\u5373\u745e\u590d\u7f8e<sup>&reg;<\/sup>[REVLIMID<sup> &reg;<\/sup>]\u52a0\u5229\u59a5\u6614\u5355\u6297\uff09\u8054\u5408\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u4e8c\u7ebf\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u7684 EZH-302\u7f8e\u56fd\u786e\u8bc1\u6027\u8bd5\u9a8c\u5236\u8ba2\u66f4\u5feb\u901f\u3001\u66f4\u5177\u8d44\u6e90\u6548\u76ca\u548c\u5730\u57df\u5305\u5bb9\u6027\u66f4\u5927\u7684\u5f00\u53d1\u8ba1<br \/>\u5212\u3002\u201d<\/p>\n<p>\u548c\u9ec4\u533b\u836f\u9996\u5e2d\u6267\u884c\u5b98\u8d3a\u96bd\u5148\u751f\uff08Mr. Christian Hogg\uff09\u8868\u793a\uff1a\u201c\u6211\u4eec\u8ba4\u4e3a TAZVERIK<sup>&reg; <\/sup>\u7684\u6d3b\u6027\u4ee5\u53ca\u5176\u63a7\u5236\u67d0\u4e9b\u57fa\u56e0\u8868\u8fbe\u7684\u8868\u89c2\u9057\u4f20\u5b66\u673a\u5236\u53ef\u4e0e\u6211\u4eec\u4e00\u7cfb\u5217\u7684\u521b\u65b0\u80bf\u7624\u5b66\u836f\u7269\u8054\u5408\u7528\u836f\uff0c\u5177\u6709\u9ad8\u5ea6\u4e92\u8865\u6027\u548c\u6f5c\u5728\u7684\u534f\u540c\u6548\u76ca\u3002\u201d\u201cTAZVERIK<sup>&reg; <\/sup>\u6f5c\u5728\u7684\u5e7f\u6cdb\u9002\u7528\u8303\u56f4\u548c\u66f4\u4f73\u7684\u5b89\u5168\u6027\uff0c\u5728\u7528\u4f5c\u8054\u5408\u7597\u6cd5\u65f6\u53ef\u8fdb\u4e00\u6b65\u6291\u5236\u80bf\u7624\u7684\u751f\u957f\u548c\u8f6c\u79fb\u3002\u662f\u6b21\u5408\u4f5c\u5c06\u52a0\u5feb\u63a2\u7d22 EZH2\u6291\u5236\u5728\u591a\u79cd\u80bf\u7624\u7c7b\u578b\uff08\u5305\u62ec\u6076\u6027\u8840\u6db2\u80bf\u7624\u548c\u5b9e\u4f53\u7624\uff09\u4e2d\u7684\u4e34\u5e8a\u6f5c\u529b\u3002\u6211\u4eec\u6df1\u4fe1\uff0cEpizyme \u4e0e\u548c\u9ec4\u533b\u836f\u5728\u5b9e\u73b0\u8fd9\u4e9b\u673a\u4f1a\u65b9\u9762\u5177\u5907\u72ec\u4e00\u65e0\u4e8c\u7684\u4f18\u52bf\uff0c\u4ece\u800c\u8fc5\u901f\u60e0\u53ca\u66f4\u591a\u7684\u4e2d\u56fd\u5883\u5185\u5916\u7684\u60a3\u8005\u3002\u201d<\/p>\n<p>\u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0c\u548c\u9ec4\u533b\u836f\u5c06\u8d1f\u8d23 TAZVERIK<sup>&reg; <\/sup>\u5728\u5927\u4e2d\u534e\u533a\u7684\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u3002Epizyme \u5c06\u6536\u53d62,500\u4e07\u7f8e\u5143\u7684\u9996\u671f\u4ed8\u6b3e\uff0c\u5e76\u5408\u8d44\u683c\u989d\u5916\u6536\u53d6\u4e0d\u8d85\u8fc71.1\u4ebf\u7f8e\u5143\u7684\u5f00\u53d1\u548c\u76d1\u7ba1\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff08\u6db5\u76d6\u6700\u591a\u516b\u4e2a\u5176\u4ed6\u6f5c\u5728\u9002\u5e94\u75c7\uff09\u4ee5\u53ca\u989d\u5916\u6536\u53d6\u4e0d\u8d85\u8fc71.75\u4ebf\u7f8e\u5143\u7684\u9500\u552e\u91cc\u7a0b\u7891\u4ed8\u6b3e\u3002Epizyme \u4ea6\u5408\u8d44\u683c\u6536\u53d6\u6839\u636e TAZVERIK<sup>&reg; <\/sup>\u5728\u5927\u4e2d\u534e\u533a\u7684\u5e74\u5ea6\u51c0\u9500\u552e\u989d\u8ba1\u7b97\u4ecb\u4e8e\u767e\u5206\u4e4b\u5341\u7684\u4e2d\u4f4d\u6570\u81f3\u767e\u5206\u4e4b\u4e8c\u5341\u7684\u4f4e\u6570\u4f4d\u4e4b\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002\u6b64\u5916\uff0c\u548c\u9ec4\u533b\u836f\u53d6\u5f97\u4e3a\u671f\u56db\u5e74\u7684\u8ba4\u80a1\u6743\u8bc1\uff0c\u4ee5\u6309\u6bcf\u80a1\u80a1\u4efd11.50\u7f8e\u5143\u7684\u4ef7\u683c\u8d2d\u4e70\u91d1\u989d\u4e0d\u8d85\u8fc76,500\u4e07\u7f8e\u5143\u7684 Epizyme \u80a1\u4efd\u3002\u9996\u671f\u4ed8\u6b3e\u5c06\u7531\u548c\u9ec4\u533b\u836f<span id=\"spanHghlt9d63\">\u4ece<\/span>\u73b0\u6709\u73b0\u91d1\u8d44\u6e90\u4e2d\u63d0\u4f9b\u8d44\u91d1\uff0c\u53e6\u5916\u9884\u671f\u6f5c\u5728\u7684\u91cc\u7a0b\u7891\u4ed8\u6b3e\u548c\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u5c06\u4ece\u672a\u6765\u73b0\u91d1\u8d44\u6e90\uff08\u5305\u62ec\u9500\u552e TAZVERIK<sup>&reg; <\/sup>\u6240\u5f97\u73b0\u91d1\uff09\u4e2d\u63d0\u4f9b\u8d44\u91d1\u3002<\/p>\n<p>\u548c\u9ec4\u533b\u836f\u8ba1\u5212\u5c06\u5728\u5176\u5730\u57df\u8d1f\u8d23 TAZVERIK<sup>&reg; <\/sup>\u7528\u4e8e\u6cbb\u7597\u5404\u79cd\u8840\u6db2\u548c\u5b9e\u4f53\u80bf\u7624\u7684\u5f00\u53d1\u5e76\u5bfb\u6c42\u6ce8\u518c\u5ba1\u6279\uff0c\u5305\u62ec\u4e0a\u76ae\u6837\u8089\u7624\u3001\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u548c\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff08DLBCL\uff09\u3002\u548c\u9ec4\u533b\u836f\u8fd8\u5c06\u4f1a\u53c2\u4e0e Epizyme \u5c31&nbsp; TAZVERIK<sup>&reg; <\/sup>\u8054\u5408R2\u65b9\u6848\u5728\u6cbb\u7597\u4e8c\u7ebf\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u7684\u5168\u7403\u6ce8\u518c\u6027\u7814\u7a76\uff0c\u5373 EZH-302\u7814\u7a76\uff0c\u5e76\u9886\u5bfc\u5728\u5927\u4e2d\u534e\u533a\u8fdb\u884c\u7684\u7814\u7a76\u3002\u6b64\u5916\uff0c\u53cc\u65b9\u62df\u5171\u540c\u5f00\u5c55\u66f4\u591a\u7684\u5168\u6027\u7403\u7814\u7a76\u3002\u4e00\u822c\u800c\u8a00\uff0c\u548c\u9ec4\u533b\u836f\u5c06\u8d1f\u8d23\u5c31 TAZVERIK<sup>&reg; <\/sup>\u5728\u5176\u5730\u57df\u5185\u8fdb\u884c\u7684\u6240\u6709\u4e34\u5e8a\u8bd5\u9a8c\u63d0\u4f9b\u8d44\u91d1\uff0c\u5305\u62ec\u5728\u8be5\u5730\u57df\u5185\u8fdb\u884c\u7684\u5168\u7403\u6027\u8bd5\u9a8c\u7684\u90e8\u5206\u3002\u5728\u53d6\u5f97\u4efb\u4f55\u6279\u51c6\u540e\uff0c\u548c\u9ec4\u533b\u836f\u5c06\u8d1f\u8d23\u5728\u5176\u6307\u5b9a\u5730\u57df\u5185\u7684 TAZVERIK<sup>&reg; <\/sup>\u5546\u4e1a\u5316\u3002\u548c\u9ec4\u533b\u836f\u4ea6\u5c06\u5728\u5730\u57df\u5185\u6301\u6709\u7814\u53d1\u548c\u751f\u4ea7 TAZVERIK<sup>&reg; <\/sup>\u7684\u6743\u5229\u3002<\/p>\n<p><b>\u7535\u8bdd\u4f1a\u8bae\u53ca\u7f51\u7edc\u76f4\u64ad<\/b><\/p>\n<p>\u548c\u9ec4\u533b\u836f\u5c06\u4e8e\u4eca\u65e5\uff082021\u5e748\u67089\u65e5\uff0c\u661f\u671f\u4e00\uff09\u4e0a\u53489\u65f630\u5206\uff08\u4e1c\u90e8\u590f\u4ee4\u65f6\u95f4\uff09\/ \u4e0b\u53482\u65f630\u5206\uff08\u683c\u6797\u5c3c\u6cbb\u65f6\u95f4\uff09&nbsp;\/ \u665a\u4e0a9\u65f630\u5206\uff08\u9999\u6e2f\u65f6\u95f4\uff09\u53ec\u5f00\u5206\u6790\u5e08\u53ca\u6295\u8d44\u8005\u7535\u8bdd\u4f1a\u8bae\u5e76\u540c\u6b65\u7f51\u7edc\u76f4\u64ad\u3002\u6295\u8d44\u8005\u53ef\u62e8\u6253\u4ee5\u4e0b\u53f7\u7801\u53c2\u4e0e\u7535\u8bdd\u4f1a\u8bae\uff1a+1 646 722 4977\uff08\u7f8e\u56fd\uff09\/ +44 20 3194 0569\uff08\u82f1\u56fd\uff09\/&nbsp; +852 3027 6500 \uff08\u9999\u6e2f\uff09\u3002\u672c\u6b21\u7535\u8bdd\u4f1a\u8bae\u5c06\u4e8e\u7f51\u7edc\u8fdb\u884c\u97f3\u9891\u540c\u6b65\u76f4\u64ad\uff0c\u5c4a\u65f6\u53ef\u4e8e\u548c\u9ec4\u533b\u836f\u7f51\u7ad9\uff08<a target=\"_blank\" href=\"https:\/\/www.hutch-med.com\/investors\/event-information\/\" rel=\"nofollow noopener\">www.hutch-med.com\/event\/<\/a>\uff09\u6536\u542c\u3002\u8bf7\u4f7f\u7528\u53c2\u4e0e\u8005\u63a5\u5165\u4ee3\u7801\uff1a\u201c<b>85770452<\/b>#\u201d\u3002<\/p>\n<p><b>\u5173\u4e8e\u8868\u89c2\u9057\u4f20\u5b66\u4f5c\u7528\u9776\u70b9<\/b><b>&nbsp;EZH2\u548c\u9776\u5411\u836f\u7269 TAZVERIK<sup>&reg;<\/sup>\uff0c\u4ee5\u53ca\u4e0e\u548c\u9ec4\u533b\u836f\u4ea7<\/b><b>\u54c1\u7ebf<\/b><b>\u7684\u534f\u540c\u6f5c\u80fd<\/b><\/p>\n<p>\u8868\u89c2\u9057\u4f20\u5b66\u662f\u6307\u5728\u4e0d\u6539\u53d8\u57fa\u56e0\u5e8f\u5217\u7684\u60c5\u51b5\u4e0b\u5bf9\u57fa\u56e0\u8868\u8fbe\u8fdb\u884c\u5e7f\u6cdb\u7684\u8c03\u8282\u3002EZH2\u662f\u4e00\u79cd\u7ec4\u86cb\u767d\u7532\u57fa\u8f6c\u79fb\u9176\uff08\u201cHMTs\u201d\uff09\uff0c\u901a\u8fc7\u50ac\u5316\u7ec4\u86cb\u767d H3\u8d56\u6c28\u917827\uff08H3K27\uff09\u7684\u7532\u57fa\u5316\u4ee5\u63a7\u5236\u5404\u79cd\u57fa\u56e0\u8868\u8fbe\uff0c\u4ece\u800c\u8c03\u8282\u7ec6\u80de\u7684\u6b63\u5e38\u751f\u7406\u529f\u80fd\u3002<\/p>\n<p>\u591a\u79cd\u764c\u75c7\u4e2d\uff0c\u5982\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u548c\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u5747\u5b58\u5728EZH2\u7684\u5931\u8c03\uff0c\u5e76\u4e0e\u4e34\u5e8a\u7684\u4e0d\u826f\u9884\u540e\u548c\u7597\u6548\u76f8\u5173\u3002[1]<sup>,<\/sup>[2]&nbsp;\u8fd9\u4e24\u79cd\u80bf\u7624\u57282020\u5e74\u5168\u7403\u65b0\u53d1\u7684\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08NHL\uff09\u75c5\u4f8b\u4e2d\u5206\u522b\u5360\u523017%\u548c32%\uff0c\u800c\u8be5\u5e74NHL\u5168\u7403\u65b0\u53d1\u75c5\u4f8b\u7ea6\u4e3a544,000\u4f8b<sup>\u3002<\/sup>[3]<sup>,<\/sup>[4]<sup>&nbsp;<\/sup>\u6b64\u5916\uff0c&nbsp;EZH2\u5931\u8c03\u8fd8\u5e38\u89c1\u4e8e\u4e73\u817a\u764c\u3001\u80ba\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u524d\u5217\u817a\u764c\u53ca\u80c3\u764c\u7b49\u5b9e\u4f53\u7624\u4e2d\uff0c\u5b83\u4eec\u57282020\u5e74\u5168\u7403\u7684\u65b0\u53d1\u75c5\u4f8b\u6570\u8d85\u8fc7\u7ea6100\u4e07\u3002<\/p>\n<p>\u8868\u89c2\u9057\u4f20\u5b66\u6291\u5236\u5242 TAZVERIK<sup>&reg; <\/sup>\u901a\u8fc7\u6291\u5236 EZH2\uff0c\u8c03\u8282\u53c2\u4e0e\u7ec6\u80de\u5468\u671f\u8c03\u63a7\u548c\u7ec8\u672b\u5206\u5316\u57fa\u56e0\u7684\u8f6c\u5f55\uff0c\u4ece\u800c\u6291\u5236\u80bf\u7624\u7ec6\u80de\u589e\u6b96\u3002\u8be5\u4f5c\u7528\u673a\u5236\u4e0e\u548c\u9ec4\u533b\u836f\u7ba1\u7ebf\u4e2d\u7684\u591a\u79cd\u6297\u80bf\u7624\u4ea7\u54c1\u9ad8\u5ea6\u4e92\u8865\uff0c\u8054\u5408\u4f7f\u7528\u5177\u6709\u534f\u540c\u589e\u6548\u7684\u6f5c\u529b\uff0c\u4f8b\u5982\uff0c\u5728\u5b9e\u4f53\u7624\u4e2d\u53ef\u63a2\u7d22\u4e0e\u9776\u5411\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08VEGFR\uff09\u836f\u7269\u544b\u55b9\u66ff\u5c3c\u7684\u8054\u5408\u7597\u6cd5\uff0c\u6216\u8005\u4e0e\u5177\u6709\u6297\u8840\u7ba1\u751f\u6210\u548c\u514d\u75ab\u8c03\u8282\u53cc\u91cd\u4f5c\u7528\u673a\u5236\u7684\u836f\u7269\u7d22\u51e1\u66ff\u5c3c\u7684\u8054\u5408\u7597\u6cd5\u3002[5]&nbsp;\u5728\u8840\u6db2\u80bf\u7624\u9886\u57df\uff0c\u53ef\u4e0e\u548c\u9ec4\u533b\u836f\u4ea7\u54c1\u7ebf\u4e2d\u7684\u591a\u4e2a\u9776\u5411B\u7ec6\u80de\u53d7\u4f53\u4fe1\u53f7\u901a\u8def\u7684\u6291\u5236\u5242\u8054\u5408\u7528\u836f\uff0c\u5305\u62ec\u5f3a\u6548\u3001\u9ad8\u9009\u62e9\u6027\u7684 PI3K<span id=\"spanHghlt17d2\">\u03b4 <\/span>\u6291\u5236\u5242 HMPL-689\u3001Syk \u6291\u5236\u5242 HMPL-523\u548c\u7b2c\u4e09\u4ee3 BTK \u6291\u5236\u5242 HMPL-760[6]\uff1b\u6b64\u5916\uff0c\u4e0e IDH1\/2\u6291\u5236\u5242 HMPL-306\uff0cERK \u6291\u5236\u5242 HMPL-295\uff0cFGFR \u6291\u5236\u5242 HMPL-453\u4ee5\u53ca CD47\u6297\u4f53 HMPL-A83\u7b49\u4ea7\u54c1\u7684\u8054\u5408\u7528\u836f\uff0c\u5747\u5177\u6709\u63a2\u7d22\u4ef7\u503c\u3002TAZVERIK<sup>&reg; <\/sup>\u5e7f\u6cdb\u7684\u9002\u7528\u6027\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u53ef\u80fd\u6709\u52a9\u4e8e\u589e\u5f3a\u8054\u5408\u7597\u6cd5\u7684\u6297\u80bf\u7624\u7597\u6548\u3002<\/p>\n<p><b>\u5173\u4e8e TAZVERIK<sup>&reg;<\/sup>&nbsp;\uff08tazemetostat\uff09<\/b><\/p>\n<p>TAZVERIK<sup>&reg;<\/sup>\u662f\u7532\u57fa\u8f6c\u79fb\u9176\u6291\u5236\u5242\uff0c\u5728\u7f8e\u56fd\u88ab\u6307\u5b9a\u7528\u4e8e\u6cbb\u7597\u4ee5\u4e0b\u60a3\u8005\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u60a3\u6709\u4e0d\u7b26\u5408\u5b8c\u5168\u5207\u9664\u6761\u4ef6\u7684\u8f6c\u79fb\u6027\u6216\u5c40\u90e8\u665a\u671f\u4e0a\u76ae\u6027\u8089\u7624\u768416\u5c81\u53ca\u4ee5\u4e0a\u7684\u6210\u4eba\u53ca\u513f\u7ae5\u60a3\u8005\u3002 <\/li>\n<li>\u590d\u53d1\u6216\u96be\u6cbb\u6027\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u7684\u6210\u4eba\u60a3\u8005\uff0c\u5176\u80bf\u7624\u7ecf FDA \u6279\u51c6\u7684\u8bd5\u9a8c\u68c0\u6d4b\u5448 EZH2\u7a81\u53d8\u9633\u6027\uff0c\u5e76\u4e14\u4e4b\u524d\u5df2\u7ecf\u63a5\u53d7\u81f3\u5c11\u4e24\u6b21\u5168\u8eab\u6cbb\u7597\u3002 <\/li>\n<li>\u590d\u53d1\u6216\u96be\u6cbb\u6027\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u7684\u6210\u4eba\u60a3\u8005\uff0c\u60df\u5e76\u65e0\u4efb\u4f55\u4ee4\u4eba\u6ee1\u610f\u7684\u66ff\u4ee3\u6cbb\u7597\u65b9\u6848\u3002<\/li>\n<\/ul>\n<p>\u4e0a\u8ff0\u9002\u5e94\u75c7\u6839\u636e\u5ba2\u89c2\u7f13\u89e3\u7387\u53ca\u548c\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u7ecf\u7f8e\u56fd FDA \u52a0\u901f\u5ba1\u6279\u540e\u83b7\u5f97\u6279\u51c6\u3002\u6839\u636e\u8fd9\u4e9b\u9002\u5e94\u75c7\u7ee7\u7eed\u6388\u4e88\u7684\u6279\u51c6\u53ef\u80fd\u53d6\u51b3\u4e8e\u786e\u8bc1\u6027\u8bd5\u9a8c\u4e2d\u7684\u4e34\u5e8a\u7597\u6548\u9a8c\u8bc1\u548c\u63cf\u8ff0\u3002<\/p>\n<p>\u8bf7\u6309\u6b64\u5904\u67e5\u770b\u7f8e\u56fd\u5b8c\u6574\u5904\u65b9\u8d44\u6599\uff1a<a target=\"_blank\" href=\"https:\/\/www.tazverik.com\/Content\/pdf\/prescribing-information.pdf\" rel=\"nofollow noopener\">www.Tazverik.com<\/a><\/p>\n<p><b>\u5173\u4e8e <\/b><b>TAZVERIK<sup>&reg; <\/sup>\u5728\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u4e2d\u7684\u52a0\u901f\u6279\u51c6<\/b><\/p>\n<p>2020\u5e746\u6708 TAZVERIK<sup>&reg; <\/sup>\u5728\u7f8e\u56fd\u83b7\u6279\u4e0a\u8ff0\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u9002\u5e94\u75c7\uff0c\u8be5\u83b7\u6279\u57fa\u4e8e\u4e00\u9879 II \u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u961f\u5217\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u6570\u636e\uff08E7438-G000-101\u7814\u7a76\uff0cclinicaltrials.gov \u6ce8\u518c\u53f7\uff1a<a target=\"_blank\" href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01897571\" rel=\"nofollow noopener\">NCT01897571<\/a>\uff09\u3002<\/p>\n<p>TAZVERIK<sup>&reg; <\/sup>\u7684\u7597\u6548\u5728\u4e00\u9879\u5f00\u653e\u6807\u7b7e\u3001\u5355\u81c2\u3001\u591a\u4e2d\u5fc3 II \u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5f97\u4ee5\u9a8c\u8bc1\uff0c\u8be5\u8bd5\u9a8c\u7eb3\u5165\u7ecf\u8fc7\u81f3\u5c11\u4e24\u7ebf\u7cfb\u7edf\u6027\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u7ecf\u7ec4\u7ec7\u5b66\u786e\u8ba4\u7684\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u60a3\u8005\u3002\u5165\u7ec4\u60a3\u8005\u5206\u4e3a\u4e24\u4e2a\u961f\u5217\uff1a\u4e00\u4e2a\u961f\u5217\u7eb3\u5165\u643a\u5e26 EZH2\u6fc0\u6d3b\u7a81\u53d8\u768445\u540d\u60a3\u8005\uff0c\u53e6\u4e00\u4e2a\u961f\u5217\u7eb3\u5165\u643a\u5e26\u91ce\u751f\u578b EZH2\u768454\u540d\u60a3\u8005\u3002\u6240\u6709\u60a3\u8005\u6bcf\u65e5\u4e24\u6b21\u53e3\u670d\u7ed9\u4e88800mg&nbsp;tazemetostat\u3002\u4e3b\u8981\u7597\u6548\u6307\u6807\u4e3a\u72ec\u7acb\u5f71\u50cf\u59d4\u5458\u4f1a\u8bc4\u4f30\u7684\u57fa\u4e8e\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u56fd\u9645\u5de5\u4f5c\u7ec4\uff08IWG-NHL\uff09\u6807\u51c6\uff08Cheson 2007\uff09\u7684ORR\u548cDOR\u3002\u4e2d\u4f4d\u968f\u8bbf\u6301\u7eed\u65f6\u95f4\u4e3a22\u4e2a\u6708\uff08\u643a\u5e26EZH2\u6fc0\u6d3b\u7a81\u53d8\u60a3\u8005\uff09\u548c36\u4e2a\u6708\uff08\u643a\u5e26\u91ce\u751f\u578bEZH2\u60a3\u8005\uff09\u3002<\/p>\n<p>\u8be5\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u4e8e<i>\u300a<a target=\"_blank\" href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1470-2045(20)30441-1\" rel=\"nofollow noopener\"><span id=\"spanHghlt1afb\">\u67f3\u53f6\u5200 \u2219 \u80bf\u7624\u5b66<\/span><\/a><\/i><i>\u300b<\/i>\u3002[7]&nbsp;\u4ee5\u4e0b\u4e3a\u836f\u7269\u6807\u7b7e\u8bf4\u660e\u4e2d\u7684\u6570\u636e\u3002\u63a5\u53d7 TAZVERIK<sup>&reg;<\/sup>\u6cbb\u7597\u7684\u643a\u5e26EZH2\u6fc0\u6d3b\u7a81\u53d8\u768445\u540d\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u60a3\u8005\u4e2d\uff0c\u4e2d\u4f4d\u5e74\u9f84\u4e3a62\u5c81\uff08\u8303\u56f4\uff1a38-80\uff09\uff1b42%\u4e3a\u7537\u6027\uff1b42%\u5728\u4e00\u7ebf\u6cbb\u7597\u540e\u51fa\u73b0\u65e9\u671f\u8fdb\u5c55\uff08\u201cPOD24\u201d\uff09\uff1b\u6240\u6709\u60a3\u8005\u4e1c\u90e8\u80bf\u7624\u534f\u4f5c\u7ec4\uff08\u201cECOG\u201d\uff09\u4f53\u80fd\u72b6\u6001\uff08\u201cPS\u201d\uff09\u8bc4\u5206\u4e3a0\u62161\u3002\u65e2\u5f80\u63a5\u53d7\u7cfb\u7edf\u6027\u6cbb\u7597\u7ebf\u6570\u4e2d\u4f4d\u503c\u4e3a2.0\uff08\u8303\u56f4\uff1a1-11\uff09\uff1b49%\u5bf9\u5229\u59a5\u6614\u5355\u6297\u8010\u836f\u800c\u4e1449%\u5bf9\u5165\u7ec4\u524d\u6700\u540e\u4e00\u6b21\u6cbb\u7597\u8010\u836f\u3002\u63a5\u53d7\u8fc7\u81f3\u5c112\u7ebf\u7cfb\u7edf\u6cbb\u7597\u768442\u540d\u60a3\u8005\u4e2d\uff0cORR\uff0895%\u7f6e\u4fe1\u533a\u95f4\uff09\u4e3a69%\uff0853%\uff0c82%\uff09\uff0c\u5176\u4e2d12%\u60a3\u8005\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\uff0c57%\u8fbe\u5230\u90e8\u5206\u7f13\u89e3\u3002\u4e2d\u4f4d DOR \u4e3a10.9\u4e2a\u6708\u3002<\/p>\n<p>\u63a5\u53d7 TAZVERIK<sup>&reg; <\/sup>\u6cbb\u7597\u7684\u643a\u5e26\u91ce\u751f\u578b EZH2\u768454\u540d\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u60a3\u8005\u4e2d\uff0c\u4e2d\u4f4d\u5e74\u9f84\u4e3a61\u5c81\uff08\u8303\u56f4\uff1a36-87\uff09\uff1b63%\u4e3a\u7537\u6027\uff1b59%\u4e3a POD24\uff1b91% ECOG PS \u8bc4\u5206\u4e3a0\u62161\u3002\u65e2\u5f80\u63a5\u53d7\u7cfb\u7edf\u6027\u6cbb\u7597\u7ebf\u6570\u4e2d\u4f4d\u503c\u4e3a3.0\uff08\u8303\u56f4\uff1a1-8\uff09\uff1b59%\u5bf9\u5229\u59a5\u6614\u5355\u6297\u8010\u836f\u4e1441%\u5bf9\u5165\u7ec4\u524d\u6700\u540e\u4e00\u6b21\u6cbb\u7597\u8010\u836f\u3002\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e8c\u7ebf\u7cfb\u7edf\u6cbb\u7597\u768453\u540d\u60a3\u8005\u4e2d\uff0cORR\uff0895%\u7f6e\u4fe1\u533a\u95f4\uff09\u4e3a34%\uff0822%\uff0c48%\uff09\uff0c\u5176\u4e2d4%\u60a3\u8005\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\uff0c30%\u8fbe\u5230\u90e8\u5206\u7f13\u89e3\u3002\u4e2d\u4f4d DOR \u4e3a13.0\u4e2a\u6708\u3002<\/p>\n<p>\u4e0d\u8bba\u76f8\u5173\u6027\uff0c\u63a5\u53d7 TAZVERIK<sup>&reg; <\/sup>\u6cbb\u7597\u7684\u60a3\u8005\u4e2d30%\u51fa\u73b0\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u3002\u63a5\u53d7 TAZVERIK<sup>&reg; <\/sup>\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u53d1\u751f\u7387\u22652%\u7684\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u4e3a\u4e00\u822c\u72b6\u51b5\u6076\u5316\u3001\u8179\u75db\u3001\u80ba\u708e\u3001\u8113\u6bd2\u75c7\uff0c\u53ca\u8d2b\u8840\u3002\u6700\u5e38\u89c1\uff08\u226520%\uff09\u4e0d\u826f\u53cd\u5e94\u4e3a\u75b2\u52b3\u3001\u4e0a\u547c\u5438\u9053\u611f\u67d3\u3001\u808c\u8089\u9aa8\u80f3\u75bc\u75db\u3001\u6076\u5fc3\u53ca\u8179\u75db\u3002<\/p>\n<p>\u8bd5\u9a8c\u4e2d8\u540d\u60a3\u8005\uff088%\uff09\u56e0\u4e0d\u826f\u53cd\u5e94\u7ec8\u6b62\u6cbb\u7597\u3002\u7814\u7a76\u4e2d\u65e0\u6b7b\u4ea1\u75c5\u4f8b\uff0c\u4e14\u65e0\u9ed1\u6846\u8b66\u544a\u6216\u7981\u5fcc\u75c7\u3002<\/p>\n<p>\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u60a3\u8005\u4e2d\u6700\u5e38\u89c1\uff08\u226520%\uff09\u7684\u4e0d\u826f\u53cd\u5e94\u662f\u75b2\u52b3\u3001\u4e0a\u547c\u5438\u9053\u611f\u67d3\u3001\u808c\u8089\u9aa8\u9abc\u75bc\u75db\u3001\u6076\u5fc3\u548c\u8179\u75db\u3002<\/p>\n<p>EZH-302\u662f\u4e00\u9879\u5168\u7403\u3001\u968f\u673a\u3001\u9002\u5e94\u6027Ib\/III\u671f\u786e\u8bc1\u6027\u4e34\u5e8a\u8bd5\u9a8c \uff08clinicaltrials.gov \u6ce8\u518c\u53f7\uff1a<a target=\"_blank\" href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04224493\" rel=\"nofollow noopener\">NCT04224493<\/a>\uff09\uff0c \u7528\u4e8e\u8bc4\u4f30 TAZVERIK<sup>&reg;<\/sup> \u8054\u5408\u5df2\u83b7\u6279\u7684\u53bb\u5316\u7597\u6cbb\u7597\u65b9\u6848R2\uff08\u745e\u590d\u7f8e<sup>&reg;<\/sup> \u52a0\u5229\u59a5\u6614\u5355\u6297\uff09\u5bf9\u6bd4R2 \u65b9\u6848\u4e0e\u5b89\u6170\u5242\u7528\u4e8e\u4e8c\u7ebf\u53ca\u4ee5\u4e0a\u6cbb\u7597\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u3002\u8be5\u8bd5\u9a8c\u9884\u8ba1\u7eb3\u5165\u7ea6500\u540d\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u60a3\u8005\u3002<\/p>\n<p><b>\u5173\u4e8e\u4e0a\u76ae\u6837\u8089\u7624\u4e2d <\/b><b>TAZVERIK<sup>&reg;<\/sup> \u4e34\u5e8a\u5f00\u53d1\u548c\u52a0\u901f\u5ba1\u6279<\/b><\/p>\n<p>2020\u5e741\u6708TAZVERIK<sup>&reg;<\/sup>\u5728\u7f8e\u56fd\u83b7\u6279\u4e0a\u8ff0\u4e0a\u76ae\u6837\u8089\u7624\u9002\u5e94\u75c7\uff0c\u8be5\u83b7\u6279\u57fa\u4e8e\u4e00\u9879II\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\u4e0a\u76ae\u6837\u8089\u7624\u961f\u5217\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u6570\u636e\u3002\uff08EZH-202\u7814\u7a76\uff0cclinicaltrials.gov \u6ce8\u518c\u53f7\uff1a<a target=\"_blank\" href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02601950\" rel=\"nofollow noopener\">NCT02601950<\/a>\uff09. <\/p>\n<p>TAZVERIK<sup>&reg; <\/sup>\u7684\u7597\u6548\u5728\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u6807\u7b7e\u7814\u7a76\u4e2d\u7684\u5355\u81c2\u961f\u5217\uff08\u961f\u52175\uff09\u8bd5\u9a8c\u4e2d\u5f97\u4ee5\u9a8c\u8bc1\uff0c\u8be5\u8bd5\u9a8c\u7eb3\u5165\u7ecf\u7ec4\u7ec7\u5b66\u786e\u8ba4\u7684\u8f6c\u79fb\u6027\u6216\u5c40\u90e8\u665a\u671f\u4e0a\u76ae\u6837\u8089\u7624\u60a3\u8005\u3002\u60a3\u8005\u9700\u8981\u5177\u6709 INI1\u7f3a\u5931\uff08\u4f7f\u7528\u5f53\u5730\u5b9e\u9a8c\u5ba4\u68c0\u6d4b\uff09\uff0c\u4ee5\u53ca0-2 ECOG PS \u8bc4\u5206\u3002\u60a3\u8005\u6bcf\u65e5\u4e24\u6b21\u53e3\u670d\u7ed9\u4e88800mg TAZVERIK<sup>&reg; <\/sup>\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u63a5\u53d7\u6bd2\u6027\u3002\u4e3b\u8981\u7597\u6548\u6307\u6807\u4e3a\u76f2\u6001\u72ec\u7acb\u4e2d\u5fc3\u8bc4\u4f30\uff08BICR\uff09\u7684\u57fa\u4e8e\u5b9e\u4f53\u7624\u7f13\u89e3\u8bc4\u4f30\u6807\u51c6\uff08RECIST\uff09v1.1\u7684\u786e\u8ba4 ORR \u548c DOR\u3002\u4e2d\u4f4d\u968f\u8bbf\u6301\u7eed\u65f6\u95f4\u4e3a14\u4e2a\u6708\uff08\u8303\u56f4\uff1a0.4-31\uff09\u3002<\/p>\n<p>\u8be5\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u4e8e<i>\u300a<span id=\"spanHghlte883\"><a target=\"_blank\" href=\"https:\/\/www.thelancet.com\/journals\/lanonc\/article\/PIIS1470-2045(20)30451-4\/fulltext\" rel=\"nofollow noopener\">\u67f3\u53f6\u5200<\/a><\/span><\/i><a target=\"_blank\" href=\"https:\/\/www.thelancet.com\/journals\/lanonc\/article\/PIIS1470-2045(20)30451-4\/fulltext\" rel=\"nofollow noopener\"><i>&nbsp;<\/i><i>\u2219<\/i><i>&nbsp;\u80bf\u7624\u5b66<\/i><\/a><i>&nbsp;<\/i><i>\u300b<\/i>\u3002[8]<sup>&nbsp;<\/sup>\u4ee5\u4e0b\u4e3a\u836f\u7269\u6807\u7b7e\u8bf4\u660e\u4e2d\u7684\u6570\u636e\u3002\u63a5\u53d7 TAZVERIK<sup>&reg; <\/sup>\u6cbb\u7597\u768462\u540d\u60a3\u8005\u4e2d\uff0c\u4e2d\u4f4d\u5e74\u9f84\u4e3a34\u5c81\uff08\u8303\u56f4\uff1a16-79\uff09\uff1b63%\u4e3a\u7537\u6027\uff0c76%\u4e3a\u767d\u79cd\u4eba\uff0c11%\u4e3a\u4e9a\u6d32\u4eba\uff0c44%\u6709\u80a2\u4f53\u8fd1\u7aef\u75be\u75c5\uff0c92% ECOG PS \u8bc4\u5206\u4e3a0\u62161\uff0c\u4ee5\u53ca8% ECOG PS \u8bc4\u5206\u4e3a2\u300277%\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u8fc7\u624b\u672f\uff1b61%\u65e2\u5f80\u63a5\u53d7\u8fc7\u7cfb\u7edf\u6027\u6cbb\u7597\u3002<\/p>\n<p>\u63a5\u53d7\u6cbb\u7597\u7684\u6240\u670962\u540d\u60a3\u8005\u4e2d\uff0cORR\uff0895%\u7f6e\u4fe1\u533a\u95f4\uff09\u4e3a15%\uff087%\uff0c26%\uff09\uff0c\u5176\u4e2d1.6%\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\uff0c13%\u8fbe\u5230\u90e8\u5206\u7f13\u89e3\u3002\u5728\u8bd5\u9a8c\u4e2d\u8fbe\u5230\u7f13\u89e3\u7684\u60a3\u8005\u4e2d\uff0c67%\u7684\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u4e3a6\u4e2a\u6708\u6216\u66f4\u957f\u3002<\/p>\n<p>\u63a5\u53d7 TAZVERIK<sup>&reg; <\/sup>\u6cbb\u7597\u7684\u60a3\u8005\u4e2d37%\u51fa\u73b0\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u3002\u63a5\u53d7 TAZVERIK<sup>&reg; <\/sup>\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u53d1\u751f\u7387\u22653%\u7684\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u4e3a\u51fa\u8840\u3001\u80f8\u8154\u79ef\u6db2\u3001\u76ae\u80a4\u611f\u67d3\u3001\u547c\u5438\u56f0\u96be\u3001\u75bc\u75db\uff0c\u53ca\u547c\u5438\u7a98\u8feb\u3002<\/p>\n<p>1\u540d\u60a3\u8005\uff082%\uff09\u56e0\u51fa\u73b0\u60c5\u7eea\u6539\u53d8\u7684\u4e0d\u826f\u53cd\u5e94\u800c\u6c38\u4e45\u6027\u7ec8\u6b62 TAZVERIK<sup>&reg; <\/sup>\u6cbb\u7597\u3002<\/p>\n<p>\u4e0a\u76ae\u6837\u8089\u7624\u60a3\u8005\u4e2d\u6700\u5e38\u89c1\uff08\u226520%\uff09\u7684\u4e0d\u826f\u53cd\u5e94\u662f\u75bc\u75db\u3001\u75b2\u52b3\u3001\u6076\u5fc3\u3001\u98df\u6b32\u4e0b\u964d\u3001\u5455\u5410\u548c\u4fbf\u79d8\u3002<\/p>\n<p>EZH-301\u662f\u4e00\u9879\u5168\u7403\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684 Ib\/III \u671f\u786e\u8bc1\u6027\u4e34\u5e8a\u8bd5\u9a8c\uff08clinicaltrials.gov\u6ce8\u518c\u53f7\uff1a<a target=\"_blank\" href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04204941\" rel=\"nofollow noopener\">NCT04204941<\/a>\uff09\uff0c \u7528\u4e8e\u8bc4\u4f30 TAZVERIK<sup>&reg; <\/sup>\u8054\u5408\u591a\u67d4\u6bd4\u661f\u5bf9\u6bd4\u591a\u67d4\u6bd4\u661f\u52a0\u5b89\u6170\u5242\u4e00\u7ebf\u6cbb\u7597\u4e0a\u76ae\u6837\u8089\u7624\u3002\u8be5\u8bd5\u9a8c\u9884\u8ba1\u7eb3\u5165\u7ea6150\u540d\u60a3\u8005\u3002<\/p>\n<p><b>\u5173\u4e8e TAZVERIK<sup>&reg; <\/sup>\u7684\u5176\u4ed6\u4e34\u5e8a\u5f00\u53d1\u8ba1\u5212<\/b><\/p>\n<p>\u9664\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u548c\u4e0a\u76ae\u6837\u8089\u7624\u7684\u7814\u7a76\u5916\uff0cTAZVERIK<sup>&reg; <\/sup>\u4ea6\u6b63\u5728\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u5f25\u6f2b\u6027\u5927 B \u7ec6\u80de\u6dcb\u5df4\u7624<span id=\"spanHghlt3582\">\u3001\u524d\u5217\u817a\u764c\u548c\u5375\u5de2\u764c<\/span>\u3002<\/p>\n<p><b>\u5173\u4e8e Epizyme, Inc.<\/b><\/p>\n<p>Epizyme, Inc. \u662f\u4e00\u5bb6\u5904\u4e8e\u5546\u4e1a\u9636\u6bb5\u7684\u5168\u9762\u4e00\u4f53\u5316\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u900f\u8fc7\u521b\u65b0\u8868\u89c2\u9057\u4f20\u5b66\u836f\u7269\uff0c\u91cd\u65b0\u5236\u8ba2\u764c\u75c7\u53ca\u5176\u4ed6\u4e25\u91cd\u75be\u75c5\u7684\u6cbb\u7597\u65b9\u6848\u3002\u9664\u4e86\u6b63\u5728\u8fdb\u884c\u7684\u7814\u7a76\u548c\u5904\u4e8e\u53d1\u73b0\u9636\u6bb5\u7684\u5728\u7814\u9879\u76ee\u5916\uff0cEpizyme \u8fd8\u6709\u4e00\u9879\u7ecf\u7f8e\u56fd FDA \u6279\u51c6\u7684\u4ea7\u54c1\uff0c\u5373\uff1aTAZVERIK<sup>&reg;<\/sup>\uff08tazemetostat\uff09\uff0c\u53ef\u7528\u4e8e\u6cbb\u7597\u4ee5\u4e0b\u8005\uff1a\u60a3\u4e0a\u8f6c\u79fb\u6027\u6216\u5c40\u90e8\u665a\u671f\u4e0a\u76ae\u6027\u8089\u7624\uff0c\u4f46\u4e0d\u7b26\u5408\u5b8c\u5168\u5207\u9664\u6761\u4ef6\u768416\u5c81\u53ca\u4ee5\u4e0a\u7684\u6210\u4eba\u53ca\u513f\u7ae5\u60a3\u8005\uff1b\u60a3\u4e0a\u590d\u53d1\u6216\u96be\u6cbb\u6027\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\uff0c\u800c\u80bf\u7624\u7ecfFDA\u6279\u51c6\u7684\u8bd5\u9a8c\u68c0\u6d4b\u5448EZH2\u7a81\u53d8\u9633\u6027\uff0c\u5e76\u4e14\u4e4b\u524d\u5df2\u7ecf\u63a5\u53d7\u81f3\u5c11\u4e24\u6b21\u5168\u8eab\u6cbb\u7597\u7684\u6210\u4eba\u60a3\u8005\uff1b\u53ca\u60a3\u4e0a\u590d\u53d1\u6216\u96be\u6cbb\u6027\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\uff0c\u60df\u5e76\u65e0\u4efb\u4f55\u4ee4\u4eba\u6ee1\u610f\u7684\u66ff\u4ee3\u6cbb\u7597\u65b9\u6848\u7684\u6210\u4eba\u60a3\u8005\u3002\u4e0a\u8ff0\u9002\u5e94\u75c7\u6839\u636e\u5ba2\u89c2\u7f13\u89e3\u7387\u53ca\u548c\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u7ecf\u7f8e\u56fd FDA \u52a0\u901f\u5ba1\u6279\u540e\u83b7\u5f97\u6279\u51c6\u3002\u6839\u636e\u8fd9\u4e9b\u9002\u5e94\u75c7\u7ee7\u7eed\u83b7\u6388\u4e88\u6279\u51c6\u53ef\u80fd\u53d6\u51b3\u4e8e\u786e\u8bc1\u6027\u8bd5\u9a8c\u4e2d\u7684\u4e34\u5e8a\u7597\u6548\u9a8c\u8bc1\u548c\u63cf\u8ff0\u3002\u6b64\u5916\uff0cEpizyme \u4ea6\u5728\u63a2\u7d22 tazemetostat \u5728\u5176\u4ed6\u5b9e\u4f53\u7624\u548c\u6076\u6027\u8840\u6db2\u80bf\u7624\u7684\u7814\u7a76\u6027\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684\u6cbb\u7597\u6f5c\u529b\uff0c\u5229\u7528\u5176\u4f5c\u4e3a\u590d\u53d1\u6027\u75be\u75c5\u548c\u4e00\u7ebf\u75be\u75c5\u7684\u5355\u836f\u7597\u6cd5\u548c\u8054\u5408\u7597\u6cd5\u3002\u85c9\u7740\u4e13\u6ce8\u4e8e\u75be\u75c5\u7684\u9057\u4f20\u9a71\u52a8\u56e0\u7d20\uff0cEpizyme \u5bfb\u6c42\u5c06\u836f\u7269\u4e0e\u9700\u8981\u836f\u7269\u7684\u60a3\u8005\u76f8\u5339\u914d\u3002\u5982\u6b32\u4e86\u89e3\u66f4\u591a\u8be6\u60c5\uff0c\u8bf7\u8bbf\u95ee\uff1a<a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.epizyme.com&amp;esheet=52192045&amp;newsitemid=20200320005053&amp;lan=en-US&amp;anchor=www.epizyme.com&amp;index=2&amp;md5=4466cd430eea2179519deeaae7620bae\" rel=\"nofollow noopener\">www.epizyme.com<\/a>\u3002<\/p>\n<p>TAZVERIK<sup>&reg; <\/sup>\u662f Epizyme, Inc. \u7684\u6ce8\u518c\u5546\u6807\u3002<\/p>\n<p><b>\u5173\u4e8e\u548c\u9ec4\u533b\u836f<\/b><\/p>\n<p>\u548c\u9ec4\u533b\u836f\uff08\u7eb3\u65af\u8fbe\u514b\/\u4f26\u6566\u8bc1\u4ea4\u6240\uff1aHCM\uff1b\u9999\u6e2f\u4ea4\u6613\u6240\uff1a13\uff09\u662f\u4e00\u5bb6\u5904\u4e8e\u5546\u4e1a\u5316\u9636\u6bb5\u7684\u521b\u65b0\u578b\u751f\u7269\u533b\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u53d1\u73b0\u3001\u5168\u7403\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6cbb\u7597\u764c\u75c7\u548c\u514d\u75ab\u6027\u75be\u75c5\u7684\u9776\u5411\u836f\u7269\u548c\u514d\u75ab\u7597\u6cd5\u3002\u8d85\u8fc71,400\u4eba\u7684\u4e13\u4e1a\u56e2\u961f\u5df2\u5c06\u81ea\u4e3b\u53d1\u73b0\u768411\u4e2a\u5019\u9009\u764c\u75c7\u836f\u7269\u63a8\u8fdb\u5230\u5728\u5168\u7403\u5f00\u5c55\u4e34\u5e8a\u7814\u7a76\uff0c\u5176\u4e2d\u9996\u4e09\u4e2a\u521b\u65b0\u80bf\u7624\u836f\u7269\u73b0\u5df2\u83b7\u6279\u4e0a\u5e02\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u8be6\u60c5\uff0c\u8bf7\u8bbf\u95ee\uff1a<a target=\"_blank\" href=\"http:\/\/www.hutch-med.com\/tc\" rel=\"nofollow noopener\">www.hutch-med.com<\/a>&nbsp;\u6216\u5173\u6ce8\u6211\u4eec\u7684 <a target=\"_blank\" href=\"https:\/\/www.linkedin.com\/company\/hutchmed\/\" rel=\"nofollow noopener\">LinkedIn<\/a>&nbsp;\u4e13\u9875\u3002<\/p>\n<p><b>\u524d\u77bb\u6027\u9648\u8ff0\u7684\u98ce\u9669\u63d0\u793a<\/b><\/p>\n<p><i>\u672c\u516c\u544a\u5305\u542b<\/i><i>1995\u5e74\u300a\u7f8e\u56fd\u79c1\u4eba\u8bc1\u5238\u8bc9\u8bbc\u6539\u9769\u6cd5\u6848\u300b\u201c\u5b89\u5168\u6e2f\u201d\u6761\u6b3e\u4e2d\u5b9a\u4e49\u7684\u524d\u77bb\u6027\u9648\u8ff0\u3002\u8fd9\u4e9b\u524d\u77bb\u6027\u9648\u8ff0\u53cd\u6620\u4e86\u548c\u9ec4\u533b\u836f\u4e0eEpizyme\u76ee\u524d\u5bf9\u672a\u6765\u4e8b\u4ef6\u7684\u9884\u671f\uff0c\u5305\u62ec\u5bf9 TAZVERIK<sup>&reg; <\/sup>\u7528\u4e8e\u6cbb\u7597\u4e0a\u76ae\u6837\u8089\u7624\u6216\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u60a3\u8005\u7684\u6cbb\u7597\u6f5c\u529b\u7684\u9884\u671f\uff0cTAZVERIK<sup>&reg; <\/sup>\u9488\u5bf9\u6b64\u9002\u5e94\u75c7\u53ca\u5176\u4ed6\u9002\u5e94\u75c7\u7684\u8fdb\u4e00\u6b65\u4e34\u5e8a\u7814\u7a76\u8ba1\u5212\uff0c\u5176\u9884\u671f&nbsp; TAZVERIK<sup>&reg; <\/sup>\u7684\u4e34\u5e8a\u7814\u7a76\u662f\u5426\u4f1a\u8fbe\u5230\u5176\u4e3b\u8981\u7ec8\u70b9\u6216\u7b2c\u4e8c\u7ec8\u70b9\uff0c\u6216\u8005\u6839\u636e\u52a0<\/i><i>\u901f\u5ba1\u6279\u7a0b\u5e8f<\/i><i>\u662f\u5426\u5c06\u9700\u8981\u4e0e\u76d1\u7ba1\u673a\u6784\u4f1a\u9762\uff0c\u63d0\u4ea4\u7684\u76d1\u7ba1\u6279\u51c6\u6216\u7ecf\u653f\u5e9c\u90e8\u95e8\u7684\u5ba1\u67e5\uff0c\u5bf9\u6b64\u7c7b\u7814\u7a76\u662f\u5426\u80fd\u8fbe\u5230\u5176\u4e3b\u8981\u6216\u6b21\u8981\u7ec8\u70b9\u7684\u9884\u671f\uff0c\u4ee5\u53ca\u5bf9\u6b64\u7c7b\u7814\u7a76\u5b8c\u6210\u65f6\u95f4\u548c\u7ed3\u679c\u53d1\u5e03\u7684\u9884\u671f\u3002\u524d\u77bb\u6027\u9648\u8ff0\u6d89\u53ca\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u3002\u6b64\u7c7b\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u5305\u62ec\uff08\u4f46\u4e0d\u9650\u4e8e\uff09\u4e0b\u5217\u5047\u8bbe\uff1a\u6709\u5173\u5f00\u5c55\u8bd5\u9a8c\u6216\u4e0a\u5e02<\/i><i>\u4ea7<\/i><i>\u54c1\u7684\u52a0\u901f\u5ba1\u6279\uff08\u5305\u62ec<\/i><i>&nbsp;TAZVERIK<sup>&reg;<\/sup>\u83b7\u6279\u51c6\u5728\u4e2d\u56fd\u7528\u4e8e\u6cbb\u7597\u60a3\u8005\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u7684\u6570\u636e\u5145\u8db3\u6027\u3001 TAZVERIK<sup>&reg;<\/sup>\u662f\u5426\u5c06\u5728\u5176\u4ed6\u53f8\u6cd5\u7ba1\u8f96\u533a\u83b7\u5f97\u4e0a\u76ae\u6837\u8089\u7624\u6216\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u7684\u4e0a\u5e02\u6279\u51c6\u3001\u662f\u5426\u5c06\u5728\u7f8e\u56fd\u83b7\u5f97\u5168\u9762\u6279\u51c6\u6216\u5728\u4efb\u4f55\u5176\u4ed6\u9002\u5e94\u75c7\u4e0a\u83b7\u5f97\u6279\u51c6\uff09\uff0c\u5176\u9884\u671f\u4e34\u5e8a\u524d\u7814\u7a76\u6216\u65e9\u671f\u4e34\u5e8a\u7814\u7a76\u662f\u5426\u5bf9\u65e5\u540e\u8bd5\u9a8c\u7ed3\u679c\u5177\u9884\u793a\u6027\uff08\u4f8b\u5982\u6301\u7eed\u8fdb\u884c\u7684\u786e\u8bc1\u6027\u8bd5\u9a8c\uff09\uff0cTAZVERIK<sup>&reg;<\/sup>\u7684\u5b89\u5168\u6027\uff0cTAZVERIK<sup>&reg; <\/sup>\u6210\u4e3a\u6cbb\u7597\u4e0a\u76ae\u6837\u8089\u7624\u6216\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u60a3\u8005\u65b0\u6807\u51c6\u7684\u6f5c\u529b\uff0c\u4e24\u5bb6\u516c\u53f8\u5404\u81ea\u5b9e\u73b0\u53ca\u5b8c\u6210 TAZVERIK<sup>&reg; <\/sup>\u8fdb\u4e00\u6b65\u4e34\u5e8a\u5f00\u53d1\u8ba1\u5212\u7684\u80fd\u529b\uff0c\u5c31\u7ecf\u6279\u51c6\u7684\u9002\u5e94\u75c7\u5728\u4e2d\u56fd\u6216\u5176\u4ed6\u5730\u533a\u63a8\u51fa\u4e0a\u5e02 TAZVERIK<sup>&reg; <\/sup>\u7684\u53ef\u80fd\u6027,\u4e24\u5bb6\u516c\u53f8\u5404\u81ea\u662f\u5426\u5177\u5907\u5145\u5206\u7684\u73b0\u91d1\u8d44\u6e90\u4ece\u800c\u4e3a\u5176\u53ef\u9884\u89c1\u548c\u4e0d\u53ef\u9884\u89c1\u7684\u8fd0\u8425\u8d39\u7528\u548c\u8d44\u672c\u652f\u51fa\u9700\u6c42\u63d0\u4f9b\u8d44\u91d1\uff0c\u4e0a\u8ff0\u4e8b\u4ef6\u7684\u65f6\u95f4\uff0c\u4ee5\u53ca\u65b0\u51a0\u80ba\u708e\u5168\u7403\u5927\u6d41\u884c\u5bf9\u5404\u516c\u53f8\u7684\u4e1a\u52a1\u3001\u7ecf\u8425\u4e1a\u7ee9\u53ca\u8d22\u52a1\u72b6\u51b5\u4e0e\u6574\u4f53\u7ecf\u6d4e\u3001\u76d1\u7ba1\u53ca\u653f\u6cbb\u72b6\u51b5\u5e26\u6765\u7684\u5f71\u54cd\u7b49\u3002\u6b64\u5916\uff0c\u7531\u4e8e\u67d0\u4e9b\u7814\u7a76\u4f9d\u8d56\u5176\u4ed6\u5019\u9009\u836f\u7269\u4f5c\u4e3a\u4e0e TAZVERIK<sup>&reg; <\/sup>\u7684\u8054\u5408\u7597\u6cd5\uff0c\u6b64\u7c7b\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u5305\u62ec\u4e0a\u8ff0\u5019\u9009\u836f\u7269\u6709\u5173\u5b89\u5168\u6027\u3001\u6709\u6548\u6027\u3001\u4f9b\u5e94\u548c\u76d1\u7ba1\u6279\u51c6\u65b9\u9762\u7684\u5047\u8bbe\u3002\u73b0\u6709\u548c\u6f5c\u5728\u6295\u8d44\u8005\u8bf7\u52ff\u8fc7\u5ea6\u4f9d\u8d56\u8fd9\u4e9b\u524d\u77bb\u6027\u9648\u8ff0\uff0c\u8fd9\u4e9b\u9648\u8ff0\u4ec5\u5728\u622a\u81f3\u672c\u516c\u544a\u53d1\u5e03\u5f53\u65e5\u6709\u6548\u3002\u548c\u9ec4\u533b\u836f\u4e0e Epizyme \u9884\u671f\u540e\u7eed\u4e8b\u4ef6\u548c\u53d1\u5c55\u5c06\u5bfc\u81f4\u89c2\u70b9\u6709\u53d8\uff1b\u7136\u800c\uff0c\u65e0\u8bba\u662f\u5426\u51fa\u73b0\u65b0\u8baf\u606f\u3001\u672a\u6765\u4e8b\u4ef6\u6216\u60c5\u51b5\u6216\u5176\u4ed6\u56e0\u7d20\uff0c\u4e24\u5bb6\u516c\u53f8\u5747\u4e0d\u627f\u62c5\u66f4\u65b0\u6216\u4fee\u8ba2\u672c\u516c\u544a\u6240\u542b\u8baf\u606f\u7684\u4e49\u52a1\u3002\u6709\u5173\u8fd9\u4e9b\u98ce\u9669\u548c\u5176\u4ed6\u98ce\u9669\u7684\u8fdb\u4e00\u6b65\u8ba8\u8bba\uff0c\u8bf7\u67e5\u9605\u548c\u9ec4\u533b\u836f\u5411\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\u3001AIM \u53ca\u9999\u6e2f\u8054\u5408\u4ea4\u6613\u6240\u6709\u9650\u516c\u53f8\u63d0\u4ea4\u7684\u6587\u4ef6\u3002<\/i><\/p>\n<p><b>\u5185\u5e55\u6d88\u606f<\/b><\/p>\n<p>\u672c\u516c\u544a\u5305\u542b\uff08\u6b27\u76df\uff09\u7b2c596\/2014\u53f7\u6761\u4f8b\uff08\u8be5\u6761\u4f8b\u6784\u6210\u300a2018\u5e74\u6b27\u6d32\u8054\u76df\uff08\u9000\u51fa\uff09\u6cd5\u300b\u5b9a\u4e49\u7684\u6b27\u76df\u4fdd\u7559\u6cd5\u5f8b\u7684\u4e00\u90e8\u5206\uff09\u7b2c7\u6761\u89c4\u5b9a\u7684\u5185\u5e55\u6d88\u606f\u3002<\/p>\n<div>\n<table id=\"convertedTablebe96\" cellspacing=\"0\" cellpadding=\"0\" border=\"0\" class=\"prntblns\">\n<tbody>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[1] Beguelin W, Popovic R, Teater M, et al. EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation. Cancer Cell. 2013;23(5):677-92. <\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[2] Boheng L, Chang WJ. EZH2 abnormalities in lymphoid malignancies: underlying mechanisms and therapeutic implications. J Hematol Oncol. 2019;12(1):118.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[3] NCCN Guideline on B-Cell Lymphomas.&nbsp; <a target=\"_blank\" href=\"https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/b-cell.pdf\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/b-cell.pdf<\/a>. Accessed August 4, 2021.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[4] Globocan. <a target=\"_blank\" href=\"https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/34-Non-hodgkin-lymphoma-fact-sheet.pdf\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/34-Non-hodgkin-lymphoma-fact-sheet.pdf<\/a>.&nbsp; Accessed August 4, 2021.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[5]Lu C, Han HD, Mangala LS, et al. Regulation of tumor angiogenesis by EZH2. <i>Cancer Cell.<\/i> 2010;18(2):185-197. doi:10.1016\/j.ccr.2010.06.016<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[6] Keats J, Lee A, Cunniff J,et al. Abstract 1161: EZH2 inhibitor tazemetostat demonstrates activity in preclinical models of Bruton&#8217;s tyrosine kinase inhibitor-resistant relapsed\/refractory mantle cell lymphoma. <i>Cancer Res<\/i> July 1 2021 (81) (13 Supplement) 1161; DOI: 10.1158\/1538-7445.AM2021-1161<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[7] Morschhauser F, Tilly H, Chaidos A, et al. Tazemetostat for patients with relapsed or refractory follicular lymphoma: an open-label, single-arm, multicentre, phase 2 trial. Lancet Oncol. 2020;21(11):1433-1442. doi:10.1016\/S1470-2045(20)30441-1<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[8] Gounder M, Schoffski P, Jones RL, et al. Tazemetostat in advanced epithelioid sarcoma with loss of INI1\/SMARCB1: an international, open-label, phase 2 basket study. Lancet Oncol. 2020;21(11):1423-1432. doi:10.1016\/S1470-2045(20)30451-4<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp;<\/p>\n<p>\u76f8\u5173\u94fe\u63a5 :<\/p>\n<blockquote class=\"wp-embedded-content\" data-secret=\"Vwr536Ppgo\"><p><a href=\"https:\/\/www.hutch-med.com\/\">Home<\/a><\/p><\/blockquote>\n<p><iframe class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; clip: rect(1px, 1px, 1px, 1px);\" title=\"&#8220;Home&#8221; &#8212; HUTCHMED\" src=\"https:\/\/www.hutch-med.com\/embed\/#?secret=Vwr536Ppgo\" data-secret=\"Vwr536Ppgo\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8211;&nbsp; \u662f\u6b21\u5408\u4f5c\u65e8\u5728\u4fc3\u8fdb TAZVERIK&reg; \u7684\u5168\u7403\u5f00\u53d1\uff0c\u4ee5\u53ca\u4e0e\u548c\u9ec4\u533b\u836f\u521b\u65b0\u80bf\u7624\u836f\u7269\u7684\u8054\u5408\u7597\u6cd5\u7814\u7a76 &nbsp;&#8211; 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