{"id":40025,"date":"2021-08-04T12:46:00","date_gmt":"2021-08-04T05:46:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021080412460040025"},"modified":"2021-08-04T21:38:11","modified_gmt":"2021-08-04T13:38:11","slug":"%e6%99%ae%e9%82%a3%e5%b8%83%e6%9e%97%e6%b2%bb%e7%96%97%e6%99%9a%e6%9c%9fnsclc%e5%9b%bd%e9%99%85%e5%a4%9a%e4%b8%ad%e5%bf%83iii%e6%9c%9f%e4%b8%b4%e5%ba%8a%e7%a0%94%e7%a9%b6%e8%be%be%e5%88%b0os%e4%b8%bb","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021080412460040025","title":{"rendered":"\u666e\u90a3\u5e03\u6797\u6cbb\u7597\u665a\u671fNSCLC\u56fd\u9645\u591a\u4e2d\u5fc3III\u671f\u4e34\u5e8a\u7814\u7a76\u8fbe\u5230OS\u4e3b\u8981\u7ec8\u70b9"},"content":{"rendered":"<p><p>\u7ebd\u7ea62021\u5e748\u67084\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u4e07\u6625\u533b\u836f\uff08\u201cBeyondSpring\u201d\uff0cNASDAQ\uff1aBYSI\uff09\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u5f00\u53d1\u65b0\u578b\u6297\u80bf\u7624\u7597\u6cd5\u7684\u5168\u7403\u6027\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\uff0c\u666e\u90a3\u5e03\u6797\u6cbb\u7597\u4e8c\/\u4e09\u7ebfEGFR\u91ce\u751f\u578b\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u56fd\u9645\u591a\u4e2d\u5fc3\u2162\u671f\u4e34\u5e8a\u7814\u7a76\uff08DUBLIN-3\uff09\u8fbe\u5230OS\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u3002\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u6807\u51c6\u6cbb\u7597\u591a\u897f\u4ed6\u8d5b\u76f8\u6bd4\uff0c\u666e\u90a3\u5e03\u6797\u8054\u5408\u591a\u897f\u4ed6\u8d5b\u5728OS\u4e3b\u8981\u7ec8\u70b9\u548c\u591a\u9879\u6b21\u8981\u7ec8\u70b9\uff0c\u5305\u62ecORR\u3001PFS\u300124\u6708\u751f\u5b58\u7387\u300136\u6708\u751f\u5b58\u7387\u30014\u7ea7\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u53d1\u751f\u7387\uff0c\u90fd\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u7684\u5dee\u5f02\uff0c\u7814\u7a76\u83b7\u5f97\u5706\u6ee1\u6210\u529f\u3002<\/p>\n<p><span class=\"xn-location\">DUBLIN<\/span>-3\u662f\u4e00\u9879\u7531<b>\u4e2d\u56fd\u8457\u540d\u4e34\u5e8a\u80bf\u7624\u5b66\u5bb6\u3001\u4e2d\u56fd\u5de5\u7a0b\u9662\u9662\u58eb\u5b59\u71d5<\/b>\u4f5c\u4e3a\u603bPI\u7684\u968f\u673a\u3001\u5355\u76f2\u3001\u9633\u6027\u5bf9\u7167\u7684\u56fd\u9645\u591a\u4e2d\u5fc3\u2162\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u5171\u5165\u7ec4\u4e86559\u4f8bEGFR \u91ce\u751f\u578b\u3001\u5177\u6709\u53ef\u6d4b\u91cf\u80ba\u90e8\u75c5\u53d8\u7684\u4e8c\u7ebf\u548c\u4e09\u7ebfNSCLC\u60a3\u8005\u3002\u60a3\u8005\u4ee521\u5929\u4e3a\u4e00\u4e2a\u5468\u671f\u6301\u7eed\u63a5\u53d7\u6cbb\u7597\uff0c\u6839\u636e\u6cbb\u7597\u5206\u7ec4\uff0c\u5728\u6bcf\u4e2a\u6cbb\u7597\u5468\u671f\u63a5\u53d7\u591a\u897f\u4ed6\u8d5b\uff08\u7b2c1\u5929\uff0c75mg\/\u33a1\uff09\u548c\u666e\u90a3\u5e03\u6797\uff08\u7b2c1\u5929\u548c\u7b2c8\u5929\uff0c30mg\/\u33a1\uff09\u6216\u591a\u897f\u4ed6\u8d5b\u5355\u836f\uff08\u7b2c1\u5929\uff0c75mg\/\u33a1\uff09\u7684\u6cbb\u7597\u3002\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u4e3a\u603b\u751f\u5b58\u671f\uff08OS\uff09\uff0c\u7ed3\u679c\u8868\u660e\uff0c\u4e0e\u591a\u897f\u4ed6\u8d5b\u5355\u836f\u6cbb\u7597\u7ec4(D\u7ec4)\u76f8\u6bd4\uff0c\u666e\u90a3\u5e03\u6797\u4e0e\u591a\u897f\u4ed6\u8d5b\u8054\u5408\u6cbb\u7597\u7ec4(DP\u7ec4)\u5bf9OS\u7684\u6539\u5584\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u3002&nbsp;ITT\u4eba\u7fa4\u7684\u9876\u7ebf\u6570\u636e\u603b\u7ed3\u5982\u4e0b\uff08DP\uff1an=278\uff1bD\uff1an=281\uff09\u3002<\/p>\n<p><b>\u4e3b\u8981\u7ec8\u70b9<\/b>\uff1a<b>\u603b\u751f\u5b58\u671f<\/b><\/p>\n<ul type=\"disc\">\n<li>\u5e73\u5747OS\uff1ap=0.03<\/li>\n<\/ul>\n<p><b>\u5173\u952e\u6b21\u8981\u7ec8\u70b9<\/b>&nbsp;&nbsp;<\/p>\n<ul type=\"disc\">\n<li>\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09 (p&lt;0.03)&nbsp; <\/li>\n<li>\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09(p&lt;0.01)&nbsp; <\/li>\n<li>4\u7ea7\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u7684\u53d1\u751f\u7387\uff0c\u7b2c1\u7597\u7a0b\u7b2c8\u5929\uff08DP\u7ec4\uff1a5.3% vs. D\u7ec4\uff1a27.8%\uff1bp&lt;0.0001\uff09 <\/li>\n<li>24\u4e2a\u6708OS\u7387\uff08DP\u7ec4\uff1a22.1% vs. &nbsp;D\u7ec4\uff1a12.5%\uff1bp&lt;0.01\uff09&nbsp; <\/li>\n<li>36\u4e2a\u6708OS\u7387\uff08DP\u7ec4\uff1a11.7% vs. D\u7ec4\uff1a5.3%\uff1bp=0.04\uff09 <\/li>\n<li>48\u4e2a\u6708OS\u7387\uff08DP\u7ec4\uff1a10.6% vs. D\u7ec4\uff1a0%\uff1bp\u503c\u65e0\u6cd5\u8ba1\u7b97\uff09&nbsp;<\/li>\n<\/ul>\n<p><b>\u5b89\u5168\u6027\u7ec8\u70b9\uff1a<\/b>&nbsp;<\/p>\n<ul type=\"disc\">\n<li>DP\u7ec44\u7ea7AE\u53d1\u751f\u7387\u6bd4D\u7ec4\u66f4\u4f4e <\/li>\n<li>\u672a\u53d1\u73b0\u975e\u9884\u671f\u7684\u5b89\u5168\u6027\u4e8b\u4ef6<\/li>\n<\/ul>\n<p>\u6ce8\uff1aDUBLIN-3\u7814\u7a76\u7684\u5b8c\u6574\u6570\u636e\u548c\u5176\u5b83\u4e3b\u8981\u6570\u636e\u5c06\u4e8e\u8fd1\u671f\u5728\u5168\u7403\u4e3b\u8981\u5b66\u672f\u5927\u4f1a\u4e0a\u53d1\u8868\u3002<\/p>\n<p>\u666e\u90a3\u5e03\u6797\u80fd\u591f\u6fc0\u6d3b\u514d\u75ab\u9632\u5fa1\u86cb\u767d\u9e1f\u560c\u5464\u6838\u82f7\u9178\u4ea4\u6362\u56e0\u5b50\uff08GEF-H1\uff09\uff0c\u5145\u5206\u52a8\u5458\u4eba\u4f53\u514d\u75ab\u7cfb\u7edf\uff0c\u5728\u53d1\u6325\u6297\u80bf\u7624\u4f5c\u7528\u7684\u540c\u65f6\u964d\u4f4e\u5316\u7597\u836f\u7269\u5bf9\u514d\u75ab\u7cfb\u7edf\u7684\u635f\u5bb3\u3002\u5728DUBLIN-3\u7814\u7a76\u4e2d\uff0cDP\u7ec4\u60a3\u8005\u80fd\u591f\u8010\u53d7\u66f4\u591a\u5468\u671f\u7684\u5316\u7597\uff0c\u957f\u671f\u751f\u5b58\u7684\u60a3\u8005\u6570\u4e5f\u66f4\u591a\uff0c\u8054\u5408\u7528\u836f\u663e\u793a\u51fa\u826f\u597d\u7684\u98ce\u9669\u53d7\u76ca\u6bd4\uff0c\u6709\u671b\u6539\u53d8\u6b64\u9886\u57df\u7684\u6cbb\u7597\u73b0\u72b6\u3002<\/p>\n<p>\u5b59\u71d5\u9662\u58eb\u8bf4\uff1a\u201c\u666e\u90a3\u5e03\u6797\u901a\u8fc7DUBLIN-3\u8fd9\u4e00\u5173\u952e\u6027\u7814\u7a76\u6210\u529f\u5730\u8bc1\u660e\u4e86\u5176\u5728 OS \u4e0a\u7684\u83b7\u76ca\uff0c\u8fd9\u662f\u81ea2015 \u5e74\u7eb3\u6b66\u5355\u6297\u6279\u51c6\u4ee5\u6765\u9996\u6b21\u6709\u5168\u65b0\u673a\u5236\u7684\u836f\u7269\u5728OS\u83b7\u76ca\u4e0a\u53d6\u5f97\u7a81\u7834\u3002\u8fd9\u4e2a\u4e34\u5e8a\u6210\u529f\u662f\u4e00\u4e2a\u4ee4\u4eba\u9f13\u821e\u7684\u559c\u8baf\uff0cDUBLIN-3\u7684\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u8be5\u7814\u7a76\u5b8c\u7f8e\u8fbe\u5230\u4e86\u9884\u5b9a\u7684\u5404\u9879\u76ee\u6807\uff0c\u4e3a\u665a\u671fEGFR\u91ce\u751f\u578b\u7684NSCLC\u60a3\u8005\u63d0\u4f9b\u4e86\u66f4\u4f18\u6548\u7684\u540e\u7ebf\u6cbb\u7597\u65b9\u6848\u3002\u666e\u90a3\u5e03\u6797\u8054\u5408\u5316\u7597\u4e0d\u4ec5\u6539\u5584\u4e86\u8010\u53d7\u6027\u548c\u751f\u6d3b\u8d28\u91cf\uff0c\u800c\u4e14\u57282\u5e74\uff0c3\u5e74\u751f\u5b58\u671f\u6bd4\u4f8b\u4e0a\uff0c\u90fd\u6bd4\u591a\u897f\u4ed6\u8d5b\u63d0\u9ad8\u4e00\u500d\uff0c\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u3002\u7814\u7a76\u7ed3\u679c\u6709\u529b\u5730\u8bc1\u660e\u4e86\u6211\u4eec\u5728\u8054\u5408\u7528\u836f\u65b9\u9762\u591a\u5e74\u8ffd\u6c42\u7684\u2018\u589e\u6548\u51cf\u6bd2\u2019\u7406\u5ff5\uff0c\u662f\u6211\u4eec\u5728\u65b0\u65f6\u4ee3\u7684\u65b0\u7a81\u7834\u3002\u53e6\u5916\u4e00\u9879\u666e\u90a3\u5e03\u6797\u8054\u5408PD-1\u53caCTLA4\u6291\u5236\u5242\u6cbb\u7597SCLC\u7684\u7814\u7a76\u4e5f\u663e\u793a\u4e86\u4ee4\u4eba\u6b23\u559c\u7684\u7597\u6548\u3002\u8fd9\u8ba9\u6211\u4eec\u5bf9\u5168\u7403\u9996\u521b\u5c0f\u5206\u5b50\u514d\u75ab\u6297\u80bf\u7624\u65b0\u836f\u666e\u90a3\u5e03\u6797\u5145\u6ee1\u4e86\u671f\u5f85\u3002\u201d<\/p>\n<p>Piedmont\u764c\u75c7\u7814\u7a76\u6240\u7684Trevor M. 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