{"id":39224,"date":"2021-07-29T10:11:00","date_gmt":"2021-07-29T03:11:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021072910110039224"},"modified":"2021-07-29T21:40:37","modified_gmt":"2021-07-29T13:40:37","slug":"ambiopharm%e4%b8%8e%e5%8a%a0%e5%b7%9e%e5%a4%a7%e5%ad%a6%e6%88%b4%e7%bb%b4%e6%96%af%e5%88%86%e6%a0%a1%e5%90%88%e4%bd%9c%e5%bc%80%e5%8f%91%e9%9d%9e%e9%98%bf%e7%89%87%e7%b1%bb%e9%95%87%e7%97%9b%e8%82%bd","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021072910110039224","title":{"rendered":"AmbioPharm\u4e0e\u52a0\u5dde\u5927\u5b66\u6234\u7ef4\u65af\u5206\u6821\u5408\u4f5c\u5f00\u53d1\u975e\u963f\u7247\u7c7b\u9547\u75db\u80bd\u836f\u7269"},"content":{"rendered":"

\u4e0a\u6d772021\u5e747\u670829\u65e5 \/\u7f8e\u901a\u793e\/ — \u8fd1\u65e5\uff0cAmbioPharm\uff08\u6602\u535a\u5236\u836f\uff09\u4e0e\u52a0\u5dde\u5927\u5b66\u6234\u7ef4\u65af\u5206\u6821\u5408\u4f5c\u5f00\u53d1\u975e\u963f\u7247\u7c7b\u9547\u75db\u80bd\u836f\u7269\uff0c\u8be5\u9547\u75db\u80bd\u662f\u57fa\u4e8e\u79d8\u9c81\u7684\u7eff\u8272\u5929\u9e45\u7ed2\u72fc\u86db (Thrixopelma pruriens) \u53d1\u73b0\u7684\uff0c\u5e76\u5229\u7528\u73b0\u4ee3\u8ba1\u7b97\u751f\u7269\u5b66\u6280\u672f\u8bbe\u8ba1\u800c\u6210\u3002\u8be5\u5408\u6210\u80bd\u80fd\u6709\u6548\u963b\u65ad\u7535\u538b\u95e8\u63a7\u6027\u94a0\u79bb\u5b50\u901a\u9053 Nav1.7\uff0c\u5e76\u4e0d\u4f1a\u4ea7\u751f\u526f\u4f5c\u7528\u3002AmbioPharm \u5c06\u5408\u6210\u8be5\u65b0\u578b\u590d\u6742\u7684\u72fc\u86db\u6bd2\u80bd\u5206\u5b50\uff0c\u5728\u4ece\u53d1\u73b0\u5230\u5546\u4e1a\u751f\u4ea7\u7684\u5404\u9636\u6bb5\u4e2d\u4e3a\u7814\u7a76\u4eba\u5458\u63d0\u4f9b\u670d\u52a1\u3002<\/span><\/p>\n

 <\/p>\n

\u7f8e\u56fd\u8fd11\/5\uff08<\/span>\u7ea65000\u4e07\uff09<\/span>\u6210\u5e74\u4eba\u60a3\u6709\u6162\u6027\u75bc\u75db\uff0c\u5176\u4e2d\uff0c\u67091100\u4e07\u4eba\u53d7\u5230\u9ad8\u51b2\u51fb\u6027\u6162\u6027\u75bc\u75db\u7684\u5f71\u54cd\u3002\u6162\u6027\u75bc\u75db\u901a\u5e38\u6301\u7eed6\u4e2a\u6708\u4ee5\u4e0a\uff0c\u5bf9\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\u9020\u6210\u8d1f\u9762\u5f71\u54cd\u3002\u4f20\u7edf\u7684\u75bc\u75db\u6cbb\u7597\u65b9\u6848\uff0c\u5982aspirin\uff08<\/span>\u963f\u53f8\u5339\u6797\uff09<\/span>\u3001ibuprofen\uff08<\/span>\u5e03\u6d1b\u82ac\uff09<\/span>\u3001naproxen\uff08<\/span>\u8418\u666e\u751f\uff09<\/span>\u7b49\u975e\u753e\u4f53\u7c7b\u6297\u708e\u836f\u7269\u6216acetaminophen\uff08<\/span>\u6251\u70ed\u606f\u75db\uff0c\u5982\u767e\u670d\u5b81\u3001\u5fc5\u7406\u901a\u3001\u6cf0\u8bfa\uff09<\/span>\u7b49\u9547\u75db\u836f\uff0c\u901a\u5e38\u4e0d\u8db3\u4ee5\u6cbb\u7597\u8be5\u75bc\u75db\uff0c\u800c\u963f\u7247\u7c7b\u836f\u7269\u5177\u6709\u9ad8\u5ea6\u6210\u763e\u6027\uff0c\u4f1a\u5bfc\u81f4\u4e25\u91cd\u7684\u5065\u5eb7\u5371\u673a\u30022019\u5e74\uff0c\u7f8e\u56fd\u6709\u8fd15\u4e07\u4eba\u6b7b\u4e8e\u963f\u7247\u7c7b\u836f\u7269\u7684\u8fc7\u91cf\u670d\u7528\u3002\u56e0\u6b64\uff0c\u4e9f\u9700\u4e00\u79cd\u5b89\u5168\u4e14\u4e0d\u4f1a\u6210\u763e\u7684\u75bc\u75db\u6cbb\u7597\u65b9\u6848\u3002 <\/p>\n

AmbioPharm\uff08<\/span>\u6602\u535a\u5236\u836f\uff09<\/span>\u96b6\u5c5e\u4e8e Ambio Pharmaceuticals Group\uff0c\u662f\u4e00\u5bb6\u9886\u5148\u7684\u521b\u65b0\u9a71\u52a8\u578b\u591a\u80bd CMO\/ CDMO \u516c\u53f8\uff0c\u7531 Juncai (Chris) Bai<\/span> \u535a\u58eb\u521b\u7acb\u4e8e2005\u5e74\uff0c\u603b\u90e8\u4f4d\u4e8e\u7f8e\u56fd\uff0c\u5e76\u5728\u6b27\u6d32\u3001\u7f8e\u56fd\u548c\u4e9a\u6d32\u8bbe\u6709\u5206\u652f\u673a\u6784\u3002\u516c\u53f8\u805a\u7126\u4e8e\u591a\u80bd\u53ca\u5176\u76f8\u5173\u4ea7\u54c1\u7684\u5f00\u53d1\u548c\u5236\u9020\uff0c\u62e5\u6709\u8d85\u8fc714\u5e74\u7684\u7ecf\u9a8c\u548c\u4e13\u4e1a\u77e5\u8bc6\uff0c\u4e3a\u5168\u7403\u5236\u836f\uff0f<\/span>\u751f\u7269\u6280\u672f\u516c\u53f8\u751f\u4ea7\u7528\u4e8e\u7814\u7a76\u3001\u4e34\u5e8a\u5f00\u53d1\u548c\u5546\u4e1a\u5e94\u7528\u7684\u5b9a\u5236\u4ea7\u54c1\u3002\u516c\u53f8\u5728\u7f8e\u56fd\u5357\u5361\u7f57\u83b1\u7eb3\u5dde\u548c\u4e2d\u56fd\u4e0a\u6d77\u5747\u8bbe\u6709\u751f\u4ea7\u57fa\u5730\uff0c\u4e3a\u5ba2\u6237\u751f\u4ea7\u7b26\u5408 cGMP \u7684\u65b0\u5206\u5b50\u5b9e\u4f53 (NCE) \u548c\u591a\u80bd\u539f\u6599\u836f\u3002\u516c\u53f8\u62e5\u67098\u5957\u751f\u4ea7\u8bbe\u5907\u53ef\u540c\u65f6\u8fdb\u884c\u751f\u4ea7\uff0c\u7528\u4e8e\u591a\u80bd\u56fa\u76f8\u5408\u6210\u7684\u53cd\u5e94\u5668\u4f53\u79ef\u9ad8\u8fbe1000\u5347 \uff08<\/span>100\u516c\u65a4\u7c97\u80bd\uff0f<\/span>\u6279\u6b21\uff09<\/span>\uff0c\u6eb6\u6db2\u53cd\u5e94\u5668\u4f53\u79ef\u9ad8\u8fbe5000\u5347\uff08<\/span>200\u516c\u65a4\u7c97\u80bd\uff0f<\/span>\u6279\u6b21\uff09<\/span>\u3002\u6b64\u5916\uff0c\u516c\u53f8\u8fd8\u62e5\u6709100 cm \u7684 HPLC \u7eaf\u5316\u7cfb\u7edf\u548c\u591a\u4e2a\u9ad8\u8fbe1000 L \u7684\u51bb\u5e72\u7cfb\u7edf\u3002\u4f4d\u4e8e\u7f8e\u56fd\u5357\u5361\u7f57\u83b1\u7eb3\u5dde\u548c\u4e2d\u56fd\u4e0a\u6d77\u76842\u4e2a\u751f\u4ea7\u57fa\u5730\u53ef\u751f\u4ea7 g-300kg \u7ea7\u522b\u7684\u591a\u80bd\u539f\u6599\u836f\u3002 <\/p>\n

\u72fc\u86db\u9547\u75db\u80bd\u7684\u5f00\u53d1<\/b><\/p>\n

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\u76ee\u524d\uff0c\u4ece\u8718\u86db\u6bd2\u6db2\u4e2d\u5206\u79bb\u51fa\u7684\u67d0\u4e9b\u94a0\u901a\u9053\u963b\u65ad\u80bd\u5df2\u88ab\u8bc1\u660e\u53ef\u4f5c\u4e3a\u7f13\u89e3\u75bc\u75db\u7684\u6f5c\u5728\u7597\u6cd5\u3002\u5728 NIH \u8ba1\u5212\u7684\u90e8\u5206\u652f\u6301\u4e0b\uff0c\u52a0\u5dde\u5927\u5b66\u6234\u7ef4\u65af\u5206\u6821\u7684 Vladimir Yarov-Yarovoy<\/span> \u548c Heike Wulff<\/span> \u535a\u58eb\u9886\u5bfc\u7684\u7814\u7a76\u56e2\u961f\u4ece\u79d8\u9c81\u7684\u7eff\u8272\u5929\u9e45\u7ed2\u72fc\u86db (Thrixopelma pruriens) \u4e2d\u53d1\u73b0\u4e86\u4e00\u79cd\u963b\u65ad\u80bd\uff0c\u80fd\u963b\u65ad\u7535\u538b\u95e8\u63a7\u6027\u94a0\u79bb\u5b50\u901a\u9053 Nav1.7\u3002\u7535\u538b\u95e8\u63a7\u6027\u94a0\u901a\u9053\u5728\u75bc\u75db\u7684\u4ea7\u751f\u548c\u53d1\u5c55\u4e2d\u8d77\u5173\u952e\u6027\u4f5c\u7528\uff0c\u5176\u5bf9\u75bc\u75db\u4f20\u5bfc\u901a\u8def\u7279\u522b\u662f\u5916\u5468\u611f\u89c9\u795e\u7ecf\u5143\u7684\u4f5c\u7528\u4e00\u76f4\u662f\u75bc\u75db\u9886\u57df\u7684\u7814\u7a76\u70ed\u70b9\u3002 <\/p>\n

Nav1.7 \u5c5e\u4e8e\u7535\u538b\u95e8\u63a7\u6027\u94a0\u79bb\u5b50\u901a\u9053\u7684\u5176\u4e2d\u4e00\u79cd\u4e9a\u578b\uff0c\u4e3b\u8981\u5206\u5e03\u4e8e\u5916\u5468\u521d\u7ea7\u611f\u89c9\u795e\u7ecf\u5143\u548c\u4ea4\u611f\u795e\u7ecf\u8282\u795e\u7ecf\u5143\uff0c\u53c2\u4e0e\u4eba\u75bc\u75db\u4fe1\u53f7\u901a\u8def\uff0c\u4e0e\u4eba\u7c7b\u591a\u79cd\u53ef\u9057\u4f20\u7684\u75bc\u75db\u75be\u75c5\u5bc6\u5207\u76f8\u5173\u3002\u7136\u800c\uff0c\u72fc\u86db\u6bd2\u6db2\u4e2d\u7684\u5929\u7136\u80bd\u4e0d\u4ec5\u80fd\u963b\u65ad\u611f\u89c9\u795e\u7ecf\u4e2d\u7684 Nav1.7\uff0c\u8fd8\u4f1a\u963b\u65ad\u808c\u8089\u548c\u5927\u8111\u4e2d\u7684 Nav1.7\uff0c\u5bfc\u81f4\u4e25\u91cd\u7684\u526f\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u7814\u7a76\u56e2\u961f\u6ca1\u6709\u76f4\u63a5\u4ece\u72fc\u86db\u4e2d\u63d0\u53d6\u6bd2\u6db2\uff0c\u800c\u662f\u901a\u8fc7\u4f7f\u7528\u534e\u76db\u987f\u5927\u5b66\u5f00\u53d1\u7684 Rosetta \u8f6f\u4ef6\u5bf9\u72fc\u86db\u6bd2\u80bd\u8fdb\u884c\u4fee\u9970\uff0c\u5c06\u5176\u8f6c\u5316\u4e3a\u53ef\u7f13\u89e3\u75bc\u75db\u7684\u5408\u6210\u80bd\u3002\u8fd9\u79cd\u65b9\u6cd5\u88ab\u79f0\u4e3a\u201c\u6bd2\u7d20\u5de5\u7a0b\u201d\u3002\u901a\u8fc7\u8be5\u65b9\u6cd5\u5408\u6210\u7684\u80bd\u6709\u53ef\u80fd\u9632\u6b62\u80bd\u4e0e\u5176\u4ed6\u7535\u538b\u95e8\u63a7\u79bb\u5b50\u901a\u9053\u76f8\u4e92\u4f5c\u7528\u800c\u5f15\u8d77\u526f\u4f5c\u7528\uff0c\u5e76\u63d0\u9ad8\u5176\u9009\u62e9\u6027\u963b\u65ad Nav1.7 \u901a\u8def\u7684\u80fd\u529b\u3002\u540c\u65f6\uff0c\u8be5\u5408\u6210\u80bd\u8fd8\u80fd\u963b\u65ad\u9664 Nav1.7 \u5916\u7684\u5176\u4ed6\u94a0\u7535\u538b\u95e8\u63a7\u901a\u9053\u3002 <\/p>\n

\u5173\u4e8e\u9547\u75db\u80bd<\/b><\/p>\n

\u75bc\u75db\u7684\u4ea7\u751f\u8fc7\u7a0b\u8f83\u4e3a\u590d\u6742\uff0c\u6d89\u53ca\u5230\u75bc\u75db\u611f\u53d7\u5668\u3001\u4f20\u5bfc\u795e\u7ecf\u3001\u75bc\u75db\u4e2d\u67a2\u7b49\u3002\u65e9\u671f\u7684\u9547\u75db\u836f\u5927\u81f4\u53ef\u5206\u4e3a\u975e\u753e\u4f53\u7c7b\u6297\u708e\u836f\u7269\uff08<\/span>\u5982\u963f\u53f8\u5339\u6797\uff09<\/span>\u3001\u963f\u7247\u53d7\u4f53\u7c7b\uff08<\/span>\u5982\u5417\u5561\uff09<\/span>\u4ee5\u53ca\u5176\u4ed6\u8f85\u52a9\u6027\u9547\u75db\u836f\uff0c\u8fd9\u4e9b\u836f\u7269\u5bf9\u4e8e\u6162\u6027\u836f\u7269\u6709\u8f83\u597d\u7684\u7597\u6548\uff0c\u4f46\u53d7\u9650\u4e8e\u5176\u6bd2\u526f\u4f5c\u7528\u3002\u5176\u4e2d\uff0c\u963f\u53f8\u5339\u6797\u5bb9\u6613\u5bf9\u4eba\u4f53\u5faa\u73af\u7cfb\u7edf\u9020\u6210\u8f83\u5927\u635f\u4f24\uff1b\u5417\u5561\u5c5e\u4e8e\u963f\u7247\u7c7b\u836f\u7269\uff0c\u5177\u6709\u9ad8\u5ea6\u6210\u763e\u6027\u7b49\u3002\u8fd1\u5e74\u6765\uff0c\u9547\u75db\u836f\u7269\u7684\u5f00\u53d1\u5f00\u59cb\u5411\u591a\u80bd\u7b49\u5c0f\u5206\u5b50\u9886\u57df\u8f6c\u79fb\u3002\u7814\u7a76\u8868\u660e\uff0c\u6765\u6e90\u4e8e\u751f\u7269\u6bd2\u7d20\u7684\u591a\u80bd\u8868\u73b0\u51fa\u826f\u597d\u7684\u9547\u75db\u4f5c\u7528\uff0c\u4e14\u4e0e\u4f20\u7edf\u9547\u75db\u836f\u7269\u76f8\u6bd4\uff0c\u5176\u5177\u6709\u65e0\u6210\u763e\u6027\u3001\u6301\u4e45\u6027\u3001\u5b89\u5168\u6027\u8f83\u9ad8\u7b49\u663e\u8457\u4f18\u52bf\uff0c\u6709\u6f5c\u529b\u6210\u4e3a\u65b0\u578b\u9547\u75db\u836f\u7269\u3002\u9547\u75db\u80bd\u53ef\u6839\u636e\u4f5c\u7528\u673a\u5236\u5206\u4e3a\u79bb\u5b50\u901a\u9053\u7c7b\u3001\u963f\u7247\u53d7\u4f53\u7c7b\u3001\u6fc0\u9176\u7c7b\u548c\u5176\u4ed6\u7c7b\u3002<\/p>\n

\u79bb\u5b50\u901a\u9053\u7c7b<\/b><\/p>\n

\u75bc\u75db\u4fe1\u53f7\u7531\u5927\u8111\u7684\u7535\u4fe1\u53f7\u901a\u8fc7\u7ec4\u5408\u79bb\u5b50\u901a\u9053\u8fdb\u884c\u4f20\u64ad\uff0c\u8fd9\u4e9b\u79bb\u5b50\u901a\u9053\u5f71\u54cd\u8457<\/span>\u611f\u53d7\u5668\u7535\u4f4d\u53d1\u751f\u3001\u795e\u7ecf\u5174\u594b\u4f20\u5bfc\u548c\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u8c03\u63a7\u7b49\u591a\u79cd\u751f\u547d\u6d3b\u52a8\u8fc7\u7a0b\uff0c\u5e76\u5177\u6709\u9ad8\u5ea6\u9009\u62e9\u6027\u3002\u5176\u4e2d\uff0c\u94a0\u79bb\u5b50\u901a\u9053\u7684\u6d3b\u6027\u5bf9\u75db\u89c9\u7684\u5f62\u6210\u548c\u4f20\u9012\u8d77\u51b3\u5b9a\u6027\u4f5c\u7528\uff0c\u662f\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf (CNS) \u53d1\u6325\u4e2d\u67a2\u9547\u75db\u4f5c\u7528\u7684\u4e00\u5927\u91cd\u8981\u673a\u5236\u3002\u8c03\u8282\u4e2d\u67a2\u5185\u94a0\u79bb\u5b50\u7684\u6d53\u5ea6\uff0c\u53ef\u6291\u5236\u795e\u7ecf\u5143\u7684\u5174\u594b\u6027\uff0c\u4ece\u800c\u4ea7\u751f\u9547\u75db\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u591a\u6570\u9547\u75db\u836f\u5e38\u901a\u8fc7\u6291\u5236\u7535\u538b\u95e8\u63a7\u6027\u94a0\u79bb\u5b50\u901a\u9053\u5bf9\u75db\u89c9\u7684\u4f20\u5bfc\u901a\u8def\u8fdb\u884c\u963b\u65ad\u3002\u52a0\u5dde\u5927\u5b66\u6234\u7ef4\u65af\u5206\u6821\u7814\u7a76\u56e2\u961f\u53d1\u73b0\u7684\u72fc\u86db\u6bd2\u80bd\u4fbf\u5c5e\u4e8e\u8fd9\u4e00\u7c7b\u4f5c\u7528\u673a\u5236\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u5728\u591a\u79cd\u6709\u6bd2\u751f\u7269\u7684\u6bd2\u7d20\u4e2d\u5b58\u5728\u5927\u91cf\u53ef\u9776\u5411\u79bb\u5b50\u901a\u9053\u7684\u5929\u7136\u9547\u75db\u80bd\uff0c\u8fd9\u4e9b\u80bd\u7531\u4e8e\u6765\u6e90\u5e7f\u6cdb\u3001\u6bd2\u526f\u4f5c\u7528\u5c0f\u3001\u534a\u8870\u671f\u957f\u548c\u836f\u6548\u660e\u663e\u7b49\u7279\u70b9\u5907\u53d7\u5173\u6ce8\u3002 <\/p>\n

\u963f\u7247\u53d7\u4f53\u7c7b<\/b><\/p>\n

\u963f\u7247\u7c7b\u9547\u75db\u836f\u7269\u662f\u9664\u79bb\u5b50\u901a\u9053\u7c7b\u9547\u75db\u836f\u7269\u5916\u6700\u4e3a\u5e38\u89c1\u4e4b\u4e00<\/span>\u3002\u4e0d\u540c\u4e8e\u79bb\u5b50\u901a\u9053\uff0c\u963f\u7247\u53d7\u4f53\u4e3b\u8981\u901a\u8fc7 G \u86cb\u767d\u5076\u8054\u53d7\u4f53 (GPCR) \u5bb6\u65cf\u53d1\u6325\u4f5c\u7528\u3002\u5f53\u4eba\u4f53\u53d7\u5230\u75bc\u75db\u523a\u6fc0\u65f6\uff0c\u5176\u8111\u4e0b\u5782\u4f53\u5206\u6ccc\u7684\u8111\u5561\u80bd\u80fd\u4f5c\u7528\u4e8e\u963f\u7247\u53d7\u4f53\uff0c\u901a\u8fc7 G \u86cb\u767d\u5076\u8054\u673a\u5236\u6291\u5236\u817a\u6838\u82f7\u9178\u73af\u5316\u9176\uff0c\u4ee5\u5f00\u653e\u94be\u901a\u9053\u5e76\u6291\u5236\u9499\u901a\u9053\uff0c\u4ece\u800c\u51cf\u5f31\uff0f<\/span>\u963b\u6ede\u75db\u89c9\u4fe1\u53f7\u7684\u4f20\u9012\uff0c\u4ea7\u751f\u9547\u75db\u4f5c\u7528\u3002\u8fd1\u5e74\u6765\uff0c\u7814\u7a76\u4eba\u5458\u4ece\u874e\u6bd2\u3001\u86c7\u6bd2\u3001\u86db\u6bd2\u53ca\u6d77\u6d0b\u751f\u7269\u6bd2\u6db2\u4e2d\u53d1\u73b0\u4e86\u53ef\u4f5c\u7528\u4e8e\u963f\u7247\u53d7\u4f53\u7684\u5929\u7136\u80bd\uff0c\u8fd9\u4e9b\u80bd\u80fd\u6709\u6548\u7f13\u89e3\u5404\u79cd\u9510\u75db\u53ca\u6162\u6027\u75bc\u75db\u3002\u4f46\u7531\u4e8e\u6bd2\u6db2\u6d3b\u6027\u6210\u5206\u8f83\u591a\uff0c\u5206\u79bb\u7eaf\u5316\u8fc7\u7a0b\u590d\u6742\uff0c\u5bf9\u4e8e\u963f\u7247\u53d7\u4f53\u7c7b\u80bd\u7684\u7814\u7a76\u4ec5\u505c\u7559\u5728\u6bd2\u6db2\u7684\u6574\u4f53\u9547\u75db\u4f5c\u7528\u5c42\u9762\u3002 <\/p>\n

\u6fc0\u9176\u7c7b<\/b><\/p>\n

\u7814\u7a76\u53d1\u73b0\uff0c\u4e00\u4e9b\u6fc0\u9176\uff0c\u5305\u62ec\u86cb\u767d\u6fc0\u9176 A (PKA)\u3001\u86cb\u767d\u6fc0\u9176 C (PKC)\u3001\u9499\u8c03\u7d20\u4f9d\u8d56\u86cb\u767d\u6fc0\u9176 (CaMK)\u3001\u78f7\u8102\u9170\u808c\u91873-\u6fc0\u9176 (PI3K) \u7b49\u90fd\u53ef\u4ee5\u78f7\u9178\u5316\u76f8\u5173\u79bb\u5b50\u901a\u9053\uff0c\u8fdb\u800c\u8c03\u8282\u673a\u4f53\u75db\u89c9\u7684\u53d1\u751f\u3002\u5982\uff0cTRPV1\u4e3a\u4e00\u79cd\u975e\u9009\u62e9\u6027\u9633\u79bb\u5b50\u901a\u9053\uff0c\u4e5f\u662f\u4e00\u79cd\u4f24\u5bb3\u6027\u611f\u53d7\u5668\u3002\u9547\u75db\u836f\u7269\u53ef\u901a\u8fc7\u964d\u4f4e\u4e0e TRPV1 \u53cd\u5e94\u7684\u6fc0\u9176\u6d3b\u6027\uff0c\u4ece\u800c\u51cf\u5c11\u75db\u89c9\u7684\u53d1\u751f\u3002LIMK \u662f\u4e00\u79cd\u53c2\u4e0e\u7ec6\u80de\u9aa8\u67b6\u8c03\u63a7\u7684\u4e1d\u6c28\u9178\u86cb\u767d\u6fc0\u9176\uff0c\u4e0e\u4e1d\u5207\u86cb\u767d\u78f7\u9178\u5316\u7684\u86cb\u767d\u8868\u8fbe\u91cf\u5448\u6b63\u76f8\u5173\uff0c\u5f53 LIMK \u6d3b\u6027\u589e\u5f3a\u65f6\uff0c\u4f1a\u5f71\u54cd TRPV1 \u4ece\u800c\u5f15\u53d1\u75bc\u75db\u3002\u968f\u8457<\/span>\u5bf9\u75bc\u75db\u673a\u5236\u7684\u6df1\u5165\u8ba4\u8bc6\u3001\u5404\u7c7b\u591a\u80bd\u5206\u5b50\u7684\u8fdb\u4e00\u6b65\u5f00\u53d1\u548c\u751f\u7269\u4fe1\u606f\u6280\u672f\u7684\u4e0d\u65ad\u53d1\u5c55\uff0c\u5177\u6709\u9547\u75db\u4f5c\u7528\u7684\u80bd\u5728\u672a\u6765\u6709\u671b\u6210\u4e3a\u65b0\u4e00\u4ee3\u9ad8\u6548\u3001\u5b89\u5168\u7684\u9547\u75db\u836f\u7269\uff0c\u4e3a\u5e7f\u5927\u60a3\u8005\u5e26\u6765\u798f\u97f3\u3002<\/p>\n

\u5a92\u4f53\u8054\u7cfb<\/span><\/b><\/span><\/p>\n

PordaHavas
\u7535\u8bdd\uff1a (+852)3150-6788<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\u4e0a\u6d772021\u5e747\u670829\u65e5 \/\u7f8e\u901a\u793e\/ — \u8fd1\u65e5\uff0cAmbioPharm\uff08\u6602\u535a\u5236\u836f\uff09\u4e0e\u52a0\u5dde\u5927\u5b66\u6234\u7ef4\u65af\u5206\u6821\u5408\u4f5c\u5f00\u53d1\u975e\u963f\u7247\u7c7b\u9547\u75db\u80bd\u836f\u7269\uff0c\u8be5\u9547\u75db\u80bd\u662f\u57fa\u4e8e\u79d8\u9c81\u7684\u7eff\u8272\u5929\u9e45\u7ed2\u72fc\u86db (Thrixopelma pruriens) \u53d1\u73b0\u7684\uff0c\u5e76\u5229\u7528\u73b0\u4ee3\u8ba1\u7b97\u751f\u7269\u5b66\u6280\u672f\u8bbe\u8ba1\u800c\u6210\u3002\u8be5\u5408\u6210\u80bd\u80fd\u6709\u6548\u963b\u65ad\u7535\u538b\u95e8\u63a7\u6027\u94a0\u79bb\u5b50\u901a\u9053 Nav1.7\uff0c\u5e76\u4e0d\u4f1a\u4ea7\u751f\u526f\u4f5c\u7528\u3002AmbioPharm \u5c06\u5408\u6210\u8be5\u65b0\u578b\u590d\u6742\u7684\u72fc\u86db\u6bd2\u80bd\u5206\u5b50\uff0c\u5728\u4ece\u53d1\u73b0\u5230\u5546\u4e1a\u751f\u4ea7\u7684\u5404\u9636\u6bb5\u4e2d\u4e3a\u7814\u7a76\u4eba\u5458\u63d0\u4f9b\u670d\u52a1\u3002   \u7f8e\u56fd\u8fd11\/5\uff08\u7ea65000\u4e07\uff09\u6210\u5e74\u4eba\u60a3\u6709\u6162\u6027\u75bc\u75db\uff0c\u5176\u4e2d\uff0c\u67091100\u4e07\u4eba\u53d7\u5230\u9ad8\u51b2\u51fb\u6027\u6162\u6027\u75bc\u75db\u7684\u5f71\u54cd\u3002\u6162\u6027\u75bc\u75db\u901a\u5e38\u6301\u7eed6\u4e2a\u6708\u4ee5\u4e0a\uff0c\u5bf9\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\u9020\u6210\u8d1f\u9762\u5f71\u54cd\u3002\u4f20\u7edf\u7684\u75bc\u75db\u6cbb\u7597\u65b9\u6848\uff0c\u5982aspirin\uff08\u963f\u53f8\u5339\u6797\uff09\u3001ibuprofen\uff08\u5e03\u6d1b\u82ac\uff09\u3001naproxen\uff08\u8418\u666e\u751f\uff09\u7b49\u975e\u753e\u4f53\u7c7b\u6297\u708e\u836f\u7269\u6216acetaminophen\uff08\u6251\u70ed\u606f\u75db\uff0c\u5982\u767e\u670d\u5b81\u3001\u5fc5\u7406\u901a\u3001\u6cf0\u8bfa\uff09\u7b49\u9547\u75db\u836f\uff0c\u901a\u5e38\u4e0d\u8db3\u4ee5\u6cbb\u7597\u8be5\u75bc\u75db\uff0c\u800c\u963f\u7247\u7c7b\u836f\u7269\u5177\u6709\u9ad8\u5ea6\u6210\u763e\u6027\uff0c\u4f1a\u5bfc\u81f4\u4e25\u91cd\u7684\u5065\u5eb7\u5371\u673a\u30022019\u5e74\uff0c\u7f8e\u56fd\u6709\u8fd15\u4e07\u4eba\u6b7b\u4e8e\u963f\u7247\u7c7b\u836f\u7269\u7684\u8fc7\u91cf\u670d\u7528\u3002\u56e0\u6b64\uff0c\u4e9f\u9700\u4e00\u79cd\u5b89\u5168\u4e14\u4e0d\u4f1a\u6210\u763e\u7684\u75bc\u75db\u6cbb\u7597\u65b9\u6848\u3002 AmbioPharm\uff08\u6602\u535a\u5236\u836f\uff09\u96b6\u5c5e\u4e8e Ambio Pharmaceuticals Group\uff0c\u662f\u4e00\u5bb6\u9886\u5148\u7684\u521b\u65b0\u9a71\u52a8\u578b\u591a\u80bd CMO\/ CDMO \u516c\u53f8\uff0c\u7531 Juncai (Chris) Bai \u535a\u58eb\u521b\u7acb\u4e8e2005\u5e74\uff0c\u603b\u90e8\u4f4d\u4e8e\u7f8e\u56fd\uff0c\u5e76\u5728\u6b27\u6d32\u3001\u7f8e\u56fd\u548c\u4e9a\u6d32\u8bbe\u6709\u5206\u652f\u673a\u6784\u3002\u516c\u53f8\u805a\u7126\u4e8e\u591a\u80bd\u53ca\u5176\u76f8\u5173\u4ea7\u54c1\u7684\u5f00\u53d1\u548c\u5236\u9020\uff0c\u62e5\u6709\u8d85\u8fc714\u5e74\u7684\u7ecf\u9a8c\u548c\u4e13\u4e1a\u77e5\u8bc6\uff0c\u4e3a\u5168\u7403\u5236\u836f\uff0f\u751f\u7269\u6280\u672f\u516c\u53f8\u751f\u4ea7\u7528\u4e8e\u7814\u7a76\u3001\u4e34\u5e8a\u5f00\u53d1\u548c\u5546\u4e1a\u5e94\u7528\u7684\u5b9a\u5236\u4ea7\u54c1\u3002\u516c\u53f8\u5728\u7f8e\u56fd\u5357\u5361\u7f57\u83b1\u7eb3\u5dde\u548c\u4e2d\u56fd\u4e0a\u6d77\u5747\u8bbe\u6709\u751f\u4ea7\u57fa\u5730\uff0c\u4e3a\u5ba2\u6237\u751f\u4ea7\u7b26\u5408 cGMP \u7684\u65b0\u5206\u5b50\u5b9e\u4f53 (NCE) \u548c\u591a\u80bd\u539f\u6599\u836f\u3002\u516c\u53f8\u62e5\u67098\u5957\u751f\u4ea7\u8bbe\u5907\u53ef\u540c\u65f6\u8fdb\u884c\u751f\u4ea7\uff0c\u7528\u4e8e\u591a\u80bd\u56fa\u76f8\u5408\u6210\u7684\u53cd\u5e94\u5668\u4f53\u79ef\u9ad8\u8fbe1000\u5347 \uff08100\u516c\u65a4\u7c97\u80bd\uff0f\u6279\u6b21\uff09\uff0c\u6eb6\u6db2\u53cd\u5e94\u5668\u4f53\u79ef\u9ad8\u8fbe5000\u5347\uff08200\u516c\u65a4\u7c97\u80bd\uff0f\u6279\u6b21\uff09\u3002\u6b64\u5916\uff0c\u516c\u53f8\u8fd8\u62e5\u6709100 cm \u7684 HPLC \u7eaf\u5316\u7cfb\u7edf\u548c\u591a\u4e2a\u9ad8\u8fbe1000 L \u7684\u51bb\u5e72\u7cfb\u7edf\u3002\u4f4d\u4e8e\u7f8e\u56fd\u5357\u5361\u7f57\u83b1\u7eb3\u5dde\u548c\u4e2d\u56fd\u4e0a\u6d77\u76842\u4e2a\u751f\u4ea7\u57fa\u5730\u53ef\u751f\u4ea7 g-300kg \u7ea7\u522b\u7684\u591a\u80bd\u539f\u6599\u836f\u3002 \u72fc\u86db\u9547\u75db\u80bd\u7684\u5f00\u53d1 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More<\/a><\/p>\n","protected":false},"author":556,"featured_media":8278,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-39224","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/39224","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=39224"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/39224\/revisions"}],"predecessor-version":[{"id":39225,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/39224\/revisions\/39225"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/8278"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=39224"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=39224"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=39224"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}