{"id":39180,"date":"2021-07-29T06:18:00","date_gmt":"2021-07-28T23:18:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021072906180039180"},"modified":"2021-07-29T21:38:45","modified_gmt":"2021-07-29T13:38:45","slug":"%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%af%e5%86%8d%e8%8e%b7%e5%90%88%e4%bd%9c%e4%bc%99%e4%bc%b4unity-biotechnology%e9%87%8c%e7%a8%8b%e7%a2%91%e4%bb%98%e6%ac%be%ef%bc%8c%e6%8a%97%e8%a1%b0%e8%80%81%e8%8d%af","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021072906180039180","title":{"rendered":"\u4e9a\u76db\u533b\u836f\u518d\u83b7\u5408\u4f5c\u4f19\u4f34UNITY Biotechnology\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u6297\u8870\u8001\u836f\u7269UBX1325\u4e34\u5e8a\u5f00\u53d1\u8fc5\u901f\u63a8\u8fdb"},"content":{"rendered":"<table border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/mma.prnasia.com\/media2\/1419966\/logo_Logo.jpg?p=medium600\" border=\"0\" alt=\"\" title=\"logo\" hspace=\"0\" vspace=\"0\" width=\"118\" \/><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><p>\u4e2d\u56fd\u82cf\u5dde\u548c\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e022021\u5e747\u670829\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u81f4\u529b\u4e8e\u5728\u80bf\u7624\u3001\u4e59\u809d\u53ca\u4e0e\u8870\u8001\u76f8\u5173\u75be\u75c5\u7b49\u6cbb\u7597\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\u2014\u2014\u4e9a\u76db\u533b\u836f\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u5168\u7403\u6218\u7565\u5408\u4f5c\u4f19\u4f34UNITY Biotechnology, Inc.\uff08\u201cUNITY\u201d, NASDAQ:UBX\uff09\u5728\u7814Bcl-xL\u6291\u5236\u5242UBX1325\u6cbb\u7597\u665a\u671f\u8840\u7ba1\u6027\u773c\u75c5\u60a3\u8005\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u6b63\u9762\u6570\u636e\uff0c\u5e76\u5df2\u5b8c\u6210IIa\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u9996\u4f8b\u60a3\u8005\u7ed9\u836f\u3002UBX1325\u6765\u81ea\u4e9a\u76db\u533b\u836f\u6388\u6743UNITY\u7528\u4e8e\u9488\u5bf9\u5e74\u9f84\u76f8\u5173\u75be\u75c5\u836f\u7269\u4e34\u5e8a\u5f00\u53d1\u7684\u5019\u9009\u836f\u7269BM-962\u3002\u6839\u636e\u6b64\u524d\u53cc\u65b9\u8fbe\u6210\u7684\u6388\u6743\u8bb8\u53ef\u534f\u8bae\u7684\u6761\u6b3e\uff0c\u516c\u53f8\u5c06\u83b7\u5f97\u4ee5UNITY\u666e\u901a\u80a1\u5f62\u5f0f\u652f\u4ed8\u7684200\u4e07\u7f8e\u5143\u91cc\u7a0b\u7891\u4ed8\u6b3e\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder1\">\n<\/p><\/div>\n<p>UBX1325\u662f\u4e00\u79cdBcl-xL\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff0c\u662f\u9996\u4e2a\u8fdb\u5165\u773c\u79d1\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6297\u8870\u8001\u836f\u7269\u3002UBX1325\u91c7\u7528\u9776\u5411\u6291\u5236\u8870\u8001\u7ec6\u80de\u751f\u5b58\u6240\u4f9d\u8d56\u7684\u86cb\u767d\u8d28\u529f\u80fd\uff0c\u6709\u671b\u4e3a\u6297VEGF\u7597\u6cd5\u63d0\u4f9b\u4e00\u79cd\u6709\u4ef7\u503c\u7684\u66ff\u4ee3\u6216\u8f85\u52a9\u6cbb\u7597\u9009\u62e9\u3002\u636eUNITY\u53d1\u5e03\u7684\u65b0\u95fb\u7a3f\u663e\u793a<sup>1<\/sup>\uff0c\u5728\u6cbb\u7597\u665a\u671f\u7cd6\u5c3f\u75c5\u6027\u9ec4\u6591\u6c34\u80bf\uff08DME\uff09\u6216\u6e7f\u6027\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\uff08wet-AMD\uff09\u4e14\u6297VEGF\u6cbb\u7597\u65e0\u6548\u7684\u60a3\u8005\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u5927\u591a\u6570\u63a5\u53d7UBX1325\u5355\u6b21\u6ce8\u5c04\u6cbb\u7597\u7684\u60a3\u8005\u8868\u73b0\u51fa\u591a\u9879\u5173\u952e\u6027\u4e34\u5e8a\u6307\u6807\u7684\u5feb\u901f\u6539\u5584\u3002UBX1325 \u5728\u8be5\u60a3\u8005\u7fa4\u4f53\u4e2d\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u548c\u5b89\u5168\u6027\uff0c\u672a\u89c2\u5bdf\u5230\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u6216\u9650\u5236\u6027\u6bd2\u6027\u5242\u91cf\uff08DLT\uff09\u3002\u6b64\u5916\uff0c\u6cbb\u7597DME\u7684IIa\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7ed9\u836f\uff0c\u7528\u4e8e\u8bc4\u4f30&nbsp;UBX1325 \u5728\u66f4\u5e7f\u6cdb\u7684&nbsp;DME \u60a3\u8005\u7fa4\u4f53\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/p>\n<p>\u4e9a\u76db\u533b\u836f\u4e8e2016\u5e74\u4e0eUNITY\u8fbe\u6210\u6218\u7565\u6388\u6743\u8bb8\u53ef\u534f\u8bae\uff0c\u5176\u4e2d\u5305\u62ec\u5173\u4e8e\u5316\u5408\u7269\u5e93\u7684\u5408\u4f5c\u534f\u8bae\uff0cUNITY\u83b7\u6388\u6743\u53ef\u5bf9\u4e9a\u76db\u533b\u836f\u7684Bcl-2\u7cfb\u5217\u5316\u5408\u7269\u8fdb\u884c\u7b5b\u9009\uff0c\u4ee5\u7528\u4e8e\u5728\u5e74\u9f84\u76f8\u5173\u75be\u75c5\u9886\u57df\u7684\u5f00\u53d1\u3002BM-962\u88abUNITY\u9009\u4e3a\u7528\u4e8eUBX1325\u7814\u53d1\u7684\u5316\u5408\u7269\uff0c\u76f8\u5173\u5408\u4f5c\u6839\u636e\u53cc\u65b9\u534f\u8bae\u6761\u6b3e\u8fdb\u884c\u3002\u6839\u636e\u6388\u6743\u8bb8\u53ef\u534f\u8bae\uff0c\u4e9a\u76db\u533b\u836f\u62e5\u6709\u8be5\u5316\u5408\u7269\u7684\u5927\u4e2d\u534e\u5730\u533a\u6743\u76ca\uff0c\u672a\u6765\u8ba1\u5212\u548cUNITY\u6210\u7acb\u5408\u8d44\u516c\u53f8\uff0c\u5171\u540c\u5728\u4e2d\u56fd\u5e02\u573a\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u8be5\u5316\u5408\u7269\u3002<\/p>\n<p>UNITY\u81f4\u529b\u4e8e\u901a\u8fc7\u5ef6\u7f13\u3001\u963b\u6b62\u4e43\u81f3\u9006\u8f6c\u548c\u8870\u8001\u6709\u5173\u7684\u75be\u75c5\uff0c\u4ece\u800c\u5ef6\u957f\u4eba\u7c7b\u7684\u5065\u5eb7\u5bff\u547d\uff0c\u5176\u7814\u7a76\u4e3b\u8981\u96c6\u4e2d\u5728\u57fa\u4e8e\u6e05\u9664\u8870\u8001\u7ec6\u80de\u7684\u6297\u8870\u8001\u6cbb\u7597\u836f\u7269\u7684\u5f00\u53d1\u3002<\/p>\n<p>\u4e9a\u76db\u533b\u836f\u8463\u4e8b\u957f\u3001CEO\u6768\u5927\u4fca\u535a\u58eb\u8868\u793a\uff1a\u201cUBX1325\u4e34\u5e8a\u7814\u7a76\u7684\u6301\u7eed\u8fdb\u5c55\u9a8c\u8bc1\u4e86\u4e9a\u76db\u5728\u7ec6\u80de\u51cb\u4ea1\u9886\u57df\u7684\u7814\u53d1\u5b9e\u529b\u3002\u6211\u4eec\u671f\u5f85UNITY\u5728\u540e\u7eed\u4e34\u5e8a\u5f00\u53d1\u4e2d\u6709\u66f4\u591a\u65b0\u7684\u8fdb\u5c55\uff0c\u5171\u540c\u52a9\u529b\u6297\u8870\u8001\u6cbb\u7597\u836f\u7269\u7684\u5f00\u53d1\uff0c\u4e3a\u5168\u7403\u60a3\u8005\u5e26\u6765\u65b0\u7684\u5e0c\u671b\u3002\u201d<\/p>\n<p><b>\u53c2\u8003\u8d44\u6599<\/b><\/p>\n<p>1.&nbsp;&nbsp;&nbsp; UNITY Biotechnology announces positive data from Phase I clinical trial of UNX1325 in patients with advanced vascular eye disease. Link: <a target=\"_blank\" href=\"https:\/\/ir.unitybiotechnology.com\/news-releases\/news-release-details\/unity-biotechnology-announces-positive-data-phase-1-clinical\" rel=\"nofollow noopener\">https:\/\/ir.unitybiotechnology.com\/news-releases\/news-release-details\/unity-biotechnology-announces-positive-data-phase-1-clinical<\/a><\/p>\n<p>\u76f8\u5173\u94fe\u63a5 :<\/p>\n<blockquote class=\"wp-embedded-content\" data-secret=\"9tbwuFs2U8\"><p><a href=\"https:\/\/www.ascentagepharma.com\/\">A Leader in the Discovery and Development of Small Molecules that Disrupt Protein-Protein Interactions<\/a><\/p><\/blockquote>\n<p><iframe class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; clip: rect(1px, 1px, 1px, 1px);\" title=\"&#8220;A Leader in the Discovery and Development of Small Molecules that Disrupt Protein-Protein Interactions&#8221; &#8212; Ascentage Pharma\" src=\"https:\/\/www.ascentagepharma.com\/embed\/#?secret=9tbwuFs2U8\" data-secret=\"9tbwuFs2U8\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e2d\u56fd\u82cf\u5dde\u548c\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e022021\u5e747\u670829\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u81f4\u529b\u4e8e\u5728\u80bf\u7624\u3001\u4e59\u809d\u53ca\u4e0e\u8870\u8001\u76f8\u5173\u75be\u75c5\u7b49\u6cbb\u7597\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\u2014\u2014\u4e9a\u76db\u533b\u836f\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u5168\u7403\u6218\u7565\u5408\u4f5c\u4f19\u4f34UNITY Biotechnology, Inc.\uff08\u201cUNITY\u201d, NASDAQ:UBX\uff09\u5728\u7814Bcl-xL\u6291\u5236\u5242UBX1325\u6cbb\u7597\u665a\u671f\u8840\u7ba1\u6027\u773c\u75c5\u60a3\u8005\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u83b7\u6b63\u9762\u6570\u636e\uff0c\u5e76\u5df2\u5b8c\u6210IIa\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u9996\u4f8b\u60a3\u8005\u7ed9\u836f\u3002UBX1325\u6765\u81ea\u4e9a\u76db\u533b\u836f\u6388\u6743UNITY\u7528\u4e8e\u9488\u5bf9\u5e74\u9f84\u76f8\u5173\u75be\u75c5\u836f\u7269\u4e34\u5e8a\u5f00\u53d1\u7684\u5019\u9009\u836f\u7269BM-962\u3002\u6839\u636e\u6b64\u524d\u53cc\u65b9\u8fbe\u6210\u7684\u6388\u6743\u8bb8\u53ef\u534f\u8bae\u7684\u6761\u6b3e\uff0c\u516c\u53f8\u5c06\u83b7\u5f97\u4ee5UNITY\u666e\u901a\u80a1\u5f62\u5f0f\u652f\u4ed8\u7684200\u4e07\u7f8e\u5143\u91cc\u7a0b\u7891\u4ed8\u6b3e\u3002 UBX1325\u662f\u4e00\u79cdBcl-xL\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff0c\u662f\u9996\u4e2a\u8fdb\u5165\u773c\u79d1\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6297\u8870\u8001\u836f\u7269\u3002UBX1325\u91c7\u7528\u9776\u5411\u6291\u5236\u8870\u8001\u7ec6\u80de\u751f\u5b58\u6240\u4f9d\u8d56\u7684\u86cb\u767d\u8d28\u529f\u80fd\uff0c\u6709\u671b\u4e3a\u6297VEGF\u7597\u6cd5\u63d0\u4f9b\u4e00\u79cd\u6709\u4ef7\u503c\u7684\u66ff\u4ee3\u6216\u8f85\u52a9\u6cbb\u7597\u9009\u62e9\u3002\u636eUNITY\u53d1\u5e03\u7684\u65b0\u95fb\u7a3f\u663e\u793a1\uff0c\u5728\u6cbb\u7597\u665a\u671f\u7cd6\u5c3f\u75c5\u6027\u9ec4\u6591\u6c34\u80bf\uff08DME\uff09\u6216\u6e7f\u6027\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\uff08wet-AMD\uff09\u4e14\u6297VEGF\u6cbb\u7597\u65e0\u6548\u7684\u60a3\u8005\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u5927\u591a\u6570\u63a5\u53d7UBX1325\u5355\u6b21\u6ce8\u5c04\u6cbb\u7597\u7684\u60a3\u8005\u8868\u73b0\u51fa\u591a\u9879\u5173\u952e\u6027\u4e34\u5e8a\u6307\u6807\u7684\u5feb\u901f\u6539\u5584\u3002UBX1325 \u5728\u8be5\u60a3\u8005\u7fa4\u4f53\u4e2d\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u548c\u5b89\u5168\u6027\uff0c\u672a\u89c2\u5bdf\u5230\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u6216\u9650\u5236\u6027\u6bd2\u6027\u5242\u91cf\uff08DLT\uff09\u3002\u6b64\u5916\uff0c\u6cbb\u7597DME\u7684IIa\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7ed9\u836f\uff0c\u7528\u4e8e\u8bc4\u4f30&nbsp;UBX1325 \u5728\u66f4\u5e7f\u6cdb\u7684&nbsp;DME \u60a3\u8005\u7fa4\u4f53\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002 \u4e9a\u76db\u533b\u836f\u4e8e2016\u5e74\u4e0eUNITY\u8fbe\u6210\u6218\u7565\u6388\u6743\u8bb8\u53ef\u534f\u8bae\uff0c\u5176\u4e2d\u5305\u62ec\u5173\u4e8e\u5316\u5408\u7269\u5e93\u7684\u5408\u4f5c\u534f\u8bae\uff0cUNITY\u83b7\u6388\u6743\u53ef\u5bf9\u4e9a\u76db\u533b\u836f\u7684Bcl-2\u7cfb\u5217\u5316\u5408\u7269\u8fdb\u884c\u7b5b\u9009\uff0c\u4ee5\u7528\u4e8e\u5728\u5e74\u9f84\u76f8\u5173\u75be\u75c5\u9886\u57df\u7684\u5f00\u53d1\u3002BM-962\u88abUNITY\u9009\u4e3a\u7528\u4e8eUBX1325\u7814\u53d1\u7684\u5316\u5408\u7269\uff0c\u76f8\u5173\u5408\u4f5c\u6839\u636e\u53cc\u65b9\u534f\u8bae\u6761\u6b3e\u8fdb\u884c\u3002\u6839\u636e\u6388\u6743\u8bb8\u53ef\u534f\u8bae\uff0c\u4e9a\u76db\u533b\u836f\u62e5\u6709\u8be5\u5316\u5408\u7269\u7684\u5927\u4e2d\u534e\u5730\u533a\u6743\u76ca\uff0c\u672a\u6765\u8ba1\u5212\u548cUNITY\u6210\u7acb\u5408\u8d44\u516c\u53f8\uff0c\u5171\u540c\u5728\u4e2d\u56fd\u5e02\u573a\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u8be5\u5316\u5408\u7269\u3002 UNITY\u81f4\u529b\u4e8e\u901a\u8fc7\u5ef6\u7f13\u3001\u963b\u6b62\u4e43\u81f3\u9006\u8f6c\u548c\u8870\u8001\u6709\u5173\u7684\u75be\u75c5\uff0c\u4ece\u800c\u5ef6\u957f\u4eba\u7c7b\u7684\u5065\u5eb7\u5bff\u547d\uff0c\u5176\u7814\u7a76\u4e3b\u8981\u96c6\u4e2d\u5728\u57fa\u4e8e\u6e05\u9664\u8870\u8001\u7ec6\u80de\u7684\u6297\u8870\u8001\u6cbb\u7597\u836f\u7269\u7684\u5f00\u53d1\u3002 \u4e9a\u76db\u533b\u836f\u8463\u4e8b\u957f\u3001CEO\u6768\u5927\u4fca\u535a\u58eb\u8868\u793a\uff1a\u201cUBX1325\u4e34\u5e8a\u7814\u7a76\u7684\u6301\u7eed\u8fdb\u5c55\u9a8c\u8bc1\u4e86\u4e9a\u76db\u5728\u7ec6\u80de\u51cb\u4ea1\u9886\u57df\u7684\u7814\u53d1\u5b9e\u529b\u3002\u6211\u4eec\u671f\u5f85UNITY\u5728\u540e\u7eed\u4e34\u5e8a\u5f00\u53d1\u4e2d\u6709\u66f4\u591a\u65b0\u7684\u8fdb\u5c55\uff0c\u5171\u540c\u52a9\u529b\u6297\u8870\u8001\u6cbb\u7597\u836f\u7269\u7684\u5f00\u53d1\uff0c\u4e3a\u5168\u7403\u60a3\u8005\u5e26\u6765\u65b0\u7684\u5e0c\u671b\u3002\u201d \u53c2\u8003\u8d44\u6599 1.&nbsp;&nbsp;&nbsp; UNITY Biotechnology announces positive data from Phase I clinical trial of UNX1325 in patients with advanced vascular eye disease. Link: https:\/\/ir.unitybiotechnology.com\/news-releases\/news-release-details\/unity-biotechnology-announces-positive-data-phase-1-clinical \u76f8\u5173\u94fe\u63a5 : A Leader in the Discovery and Development of Small Molecules that Disrupt Protein-Protein Interactions&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2021072906180039180\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":8278,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-39180","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/39180","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=39180"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/39180\/revisions"}],"predecessor-version":[{"id":39181,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/39180\/revisions\/39181"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/8278"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=39180"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=39180"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=39180"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}