{"id":38822,"date":"2021-07-26T14:56:00","date_gmt":"2021-07-26T07:56:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021072614560038822"},"modified":"2021-07-26T21:41:03","modified_gmt":"2021-07-26T13:41:03","slug":"%e6%9d%a5%e5%87%af%e5%8c%bb%e8%8d%af%e4%b8%a4%e9%a1%b9%e4%b8%b4%e5%ba%8a%e7%a0%94%e7%a9%b6%e5%85%a5%e9%80%892021esmo%e5%b9%b4%e4%bc%9a","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021072614560038822","title":{"rendered":"\u6765\u51ef\u533b\u836f\u4e24\u9879\u4e34\u5e8a\u7814\u7a76\u5165\u90092021ESMO\u5e74\u4f1a"},"content":{"rendered":"<p><p>\u4e2d\u56fd\u4e0a\u6d77\u548c\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u6c83\u4f262021\u5e747\u670826\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u6765\u51ef\u533b\u836f\u4eca\u5929\u5ba3\u5e03\uff0c\u516c\u53f8\u4e24\u9879\u5173\u4e8e\u524d\u5217\u817a\u764c\u6cbb\u7597\u7684\u4e34\u5e8a\u7814\u7a76\u5165\u90092021\u5e74\u6b27\u6d32\u80bf\u7624\u533b\u5b66\u5b66\u4f1a\u5e74\u4f1a\uff08ESMO 2021\uff09&nbsp;\u62a5\u544a\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder3482\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/1581028\/ESMO1.html\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/esmo1.jpg\" title=\"ESMO\u5e74\u4f1a\u662f\u6b27\u6d32\u4e43\u81f3\u5168\u7403\u6700\u6743\u5a01\u3001\u6700\u5177\u5f71\u54cd\u529b\u7684\u80bf\u7624\u5b66\u4f1a\u8bae\u4e4b\u4e00\u3002\u6765\u51ef\u533b\u836f\u671f\u5f85\u5728\u4eca\u5e749\u6708\u5e74\u4f1a\u671f\u95f4\u5411\u540c\u884c\u4eec\u5206\u4eab\u66f4\u8be6\u5b9e\u7684\u4e34\u5e8a\u6570\u636e\u3002\" 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\/><span>ESMO\u5e74\u4f1a\u662f\u6b27\u6d32\u4e43\u81f3\u5168\u7403\u6700\u6743\u5a01\u3001\u6700\u5177\u5f71\u54cd\u529b\u7684\u80bf\u7624\u5b66\u4f1a\u8bae\u4e4b\u4e00\u3002\u6765\u51ef\u533b\u836f\u671f\u5f85\u5728\u4eca\u5e749\u6708\u5e74\u4f1a\u671f\u95f4\u5411\u540c\u884c\u4eec\u5206\u4eab\u66f4\u8be6\u5b9e\u7684\u4e34\u5e8a\u6570\u636e\u3002<\/span><\/p>\n<\/p><\/div>\n<p>\u8fd9\u4e24\u9879\u7814\u7a76\u5206\u522b\u662f\uff1a<\/p>\n<p><b>\u7535\u5b50\u58c1\u62a5<\/b><b>1<\/b><b>\uff1a<\/b><b>&nbsp;CYP17A<\/b><b>\u548c<\/b><b>CYP11B2<\/b><b>\u53cc\u9776\u70b9\u6291\u5236\u5242<\/b><b>(LAE001)<\/b><b>\uff0c\u5728\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u578b\u524d\u5217\u817a<\/b><b>(mCRPC)<\/b><b>\u764c\u60a3\u8005\u4e2d\u7684<\/b><b>&nbsp;I <\/b><b>\u671f\u7814\u7a76<\/b><\/p>\n<p><b>\u5c55\u793a\u7f16\u53f7\uff1a<\/b><span id=\"spanHghlta184\">597P<\/span><\/p>\n<p><b>\u4e3b\u8981\u7814\u7a76\u8005\u53ca\u62a5\u544a\u4eba\uff1a<\/b>\u53f6\u5b9a\u4f1f\u6559\u6388\uff08\u590d\u65e6\u5927\u5b66\u524d\u5217\u817a\u80bf\u7624\u7814\u7a76\u6240\u6240\u957f\uff09<\/p>\n<p>\u8fd9\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u6027\u6cbb\u7597\u6210\u5e74\u4eba\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u7684I\u671f\u4e24\u9636\u6bb5\u7814\u7a76\u7ed9\u836f\uff0c\u7528\u4e8e\u9a8c\u8bc1\u5728\u4e0d\u8054\u7528\u6cfc\u5c3c\u677e\u7684\u60c5\u51b5\u4e0b\uff0cLAE001\u5355\u836f\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u4ee5\u53ca\u4e0e\u540c\u7c7b\u4ea7\u54c1\u76f8\u6bd4\u7684\u4f18\u52bf\u3002<\/p>\n<p>LAE001\u662f<span id=\"spanHghlt42c9\">\u5168\u7403\u9996\u4e2a<\/span>&nbsp;CYP17A\u548cCYP11B2\u53cc\u9776\u70b9\u6291\u5236\u5242\uff0c\u662f\u4e00\u79cd\u65b0\u578b\u975e\u753e\u4f53\u7c7b\u3001\u53ef\u9006\u3001\u53cc\u9776\u70b9\u3001\u5f3a\u6548\u6291\u5236\u5242\u3002\u5b83\u53ef\u540c\u65f6\u6291\u5236&nbsp;CYP17A1 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src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/esmo2.jpg\" title=\"LAE001\u662f\u5168\u7403\u9996\u4e2a CYP17A\u548cCYP11B2\u53cc\u9776\u70b9\u6291\u5236\u5242\uff0c\u662f\u4e00\u79cd\u65b0\u578b\u975e\u753e\u4f53\u7c7b\u3001\u53ef\u9006\u3001\u53cc\u9776\u70b9\u3001\u5f3a\u6548\u6291\u5236\u5242\u3002\u6765\u51ef\u533b\u836f\u6b63\u52a0\u901fLAE001\u5355\u836f\u4e34\u5e8a\u7814\u7a76\uff0c\u5e0c\u671b\u60e0\u53ca\u65e9\u671f\u524d\u5217\u817a\u764c\u60a3\u8005\u3002\u7531\u4e8e\u5b83\u65e0\u9700\u548c\u6cfc\u5c3c\u677e\u5408\u7528\uff0c\u6216\u53ef\u907f\u514d\u5728\u73b0\u6709\u963f\u6bd4\u7279\u9f99\u6cbb\u7597\u6807\u51c6\u4e2d\u5bf9\u6cfc\u5c3c\u677e\u7684\u4f9d\u8d56\u53ca\u5176\u5f15\u53d1\u7684\u526f\u4f5c\u7528\uff0c\u6709\u671b\u63d0\u9ad8\u60a3\u8005\u7684\u751f\u5b58\u8d28\u91cf\u3002\" alt=\"LAE001\u662f\u5168\u7403\u9996\u4e2a CYP17A\u548cCYP11B2\u53cc\u9776\u70b9\u6291\u5236\u5242\uff0c\u662f\u4e00\u79cd\u65b0\u578b\u975e\u753e\u4f53\u7c7b\u3001\u53ef\u9006\u3001\u53cc\u9776\u70b9\u3001\u5f3a\u6548\u6291\u5236\u5242\u3002\u6765\u51ef\u533b\u836f\u6b63\u52a0\u901fLAE001\u5355\u836f\u4e34\u5e8a\u7814\u7a76\uff0c\u5e0c\u671b\u60e0\u53ca\u65e9\u671f\u524d\u5217\u817a\u764c\u60a3\u8005\u3002\u7531\u4e8e\u5b83\u65e0\u9700\u548c\u6cfc\u5c3c\u677e\u5408\u7528\uff0c\u6216\u53ef\u907f\u514d\u5728\u73b0\u6709\u963f\u6bd4\u7279\u9f99\u6cbb\u7597\u6807\u51c6\u4e2d\u5bf9\u6cfc\u5c3c\u677e\u7684\u4f9d\u8d56\u53ca\u5176\u5f15\u53d1\u7684\u526f\u4f5c\u7528\uff0c\u6709\u671b\u63d0\u9ad8\u60a3\u8005\u7684\u751f\u5b58\u8d28\u91cf\u3002\" \/><\/a><br \/><span>LAE001\u662f\u5168\u7403\u9996\u4e2a CYP17A\u548cCYP11B2\u53cc\u9776\u70b9\u6291\u5236\u5242\uff0c\u662f\u4e00\u79cd\u65b0\u578b\u975e\u753e\u4f53\u7c7b\u3001\u53ef\u9006\u3001\u53cc\u9776\u70b9\u3001\u5f3a\u6548\u6291\u5236\u5242\u3002\u6765\u51ef\u533b\u836f\u6b63\u52a0\u901fLAE001\u5355\u836f\u4e34\u5e8a\u7814\u7a76\uff0c\u5e0c\u671b\u60e0\u53ca\u65e9\u671f\u524d\u5217\u817a\u764c\u60a3\u8005\u3002\u7531\u4e8e\u5b83\u65e0\u9700\u548c\u6cfc\u5c3c\u677e\u5408\u7528\uff0c\u6216\u53ef\u907f\u514d\u5728\u73b0\u6709\u963f\u6bd4\u7279\u9f99\u6cbb\u7597\u6807\u51c6\u4e2d\u5bf9\u6cfc\u5c3c\u677e\u7684\u4f9d\u8d56\u53ca\u5176\u5f15\u53d1\u7684\u526f\u4f5c\u7528\uff0c\u6709\u671b\u63d0\u9ad8\u60a3\u8005\u7684\u751f\u5b58\u8d28\u91cf\u3002<\/span><\/p>\n<\/p><\/div>\n<p><b>\u7535\u5b50\u58c1\u62a5<\/b><b>2<\/b><b>\uff1a<\/b><b>LAE001\/<\/b><b>\u6cfc\u5c3c\u677e<\/b><b>+ afuresertib\uff08<\/b><b>\u4e00\u79cd<\/b><b>AKT<\/b><b>\u6291\u5236\u5242\uff09<\/b><b>\u8054\u5408\uff0c\u5728\u7ecf\u4e8c\u4ee3\u6297\u96c4\u6fc0\u7d20\u6cbb\u7597\u8010\u836f\u3001\u540e\u7ebf\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u578b\u524d\u5217\u817a\u764c\u60a3\u8005\u4e2d\u7684<\/b><b>I\/II<\/b><b>\u671f\u7814\u7a76<\/b><\/p>\n<p><b>\u5c55\u793a\u7f16\u53f7\uff1a<\/b><span id=\"spanHghlt6011\">599P<\/span><\/p>\n<p><span id=\"spanHghlt642b\"><b>\u62a5\u544a\u4eba\uff1aAlberto Bessudo (<span class=\"xn-location\">Encinitas, CA<\/span>, <span class=\"xn-location\">United States of America<\/span>)<\/b><\/span><\/p>\n<p>I\u671f\u8bd5\u9a8c\u4e3a\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u3001\u5242\u91cf\u9012\u589e\u7814\u7a76\uff0c\u7528\u4e8e\u5bf9\u5148\u524d\u63a5\u53d7\u8fc7\u4e8c\u4ee3\u6297\u96c4\u6fc0\u7d20\u6216\u5316\u7597\u8fd92\u79cd\u6807\u51c6\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u8010\u53d7\u6297\u96c4\u6fc0\u7d20\u7684\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u578b\u524d\u5217\u817a\u764c(mCRPC)\u60a3\u8005\uff0c\u8bc4\u4f30\u5b89\u5168\u6027\u5e76\u786e\u5b9a\u5728&nbsp;mCRPC \u4e2d&nbsp;LAE001\/\u6cfc\u5c3c\u677e\u548c&nbsp;afuresertib \u8054\u5408\u6cbb\u7597\u7684\u63a8\u8350&nbsp;2 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