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01a\u8fc7\u5408\u4f5c\u5f15\u8fdb\u548c\u81ea\u4e3b\u7814\u53d1\uff0c\u5efa\u7acb\u4e86\u4e00\u6761\u4ece\u4e34\u5e8a\u524d\u5230\u4e34\u5e8a\u9636\u6bb5\u4e0d\u65ad\u5ef6\u5c55\u7684\u4e30\u5bcc\u4ea7\u54c1\u7ba1\u7ebf\u3002\u76ee\u524d\uff0c\u5fb7\u742a\u533b\u836f\u5df2\u5728\u591a\u4e2a\u4e9a\u592a\u5e02\u573a\u83b7\u5f9715\u4e2a\u4e34\u5e8a\u6279\u4ef6\uff08IND\uff09\uff0c\u5e76\u9012\u4ea4\u4e866\u4e2a\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\uff08NDA\uff09\u3002\u5fb7\u742a\u533b\u836f\u5c06\u4ee5\u201c\u533b\u8005\u65e0\u7586\uff0c\u521b\u65b0\u6c38\u7eed\u201d\u4e3a\u613f\u666f\uff0c\u4e13\u6ce8\u4e8e\u540c\u7c7b\u9996\u6b3e\u548c\u540c\u7c7b\u6700\u4f18\u7597\u6cd5\u7684\u65e9\u671f\u7814\u53d1\u3001\u4e34\u5e8a\u7814\u7a76\u3001\u836f\u7269\u751f\u4ea7\u53ca\u5546\u4e1a\u5316\uff0c\u89e3\u51b3\u4e9f\u5f85\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u3002<\/p>\n<p><b>\u5173\u4e8e\u585e\u5229\u5c3c\u7d22<\/b><\/p>\n<p>\u585e\u5229\u5c3c\u7d22\u662f\u76ee\u524d\u9996\u6b3e\u4e14\u552f\u4e00\u4e00\u6b3e\u88ab\u7f8e\u56fdFDA\u6279\u51c6\u7684\u53e3\u670dSINE\u5316\u5408\u7269\uff0c\u4e5f\u662f\u9996\u6b3e\u53ef\u7528\u4e8e\u6cbb\u7597\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u548c\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u7684\u836f\u7269\u3002\u901a\u8fc7\u6291\u5236\u6838\u8f93\u51fa\u86cb\u767dXPO1\uff0c\u4fc3\u4f7f\u80bf\u7624\u6291\u5236\u86cb\u767d\u548c\u5176\u4ed6\u751f\u957f\u8c03\u8282\u86cb\u767d\u7684\u6838\u5185\u50a8\u7559\u548c\u6d3b\u5316\uff0c\u5e76\u4e0b\u8c03\u7ec6\u80de\u6d46\u5185\u591a\u79cd\u81f4\u764c\u86cb\u767d\u6c34\u5e73\uff0c\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\uff0c\u800c\u6b63\u5e38\u7ec6\u80de\u4e0d\u53d7\u5f71\u54cd\u3002\u57fa\u4e8e\u5176\u72ec\u7279\u7684\u4f5c\u7528\u673a\u5236\uff0c\u585e\u5229\u5c3c\u7d22\u53ef\u4e0e\u5176\u4ed6\u591a\u4e2a\u836f\u7269\u8054\u7528\u4ee5\u63d0\u9ad8\u7597\u6548\u3002<\/p>\n<p>\u5f53\u524d\u6b63\u5728\u8fdb\u5c55\u4e2d\u7684\u8840\u6db2\u80bf\u7624\u76f8\u5173\u4e34\u5e8a\u8bd5\u9a8c\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u585e\u5229\u5c3c\u7d22\u8054\u5408\u5730\u585e\u7c73\u677e\u6cbb\u7597\u591a\u836f\u96be\u6cbb\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5728\u4e2d\u56fd\u5927\u9646\u5f00\u5c55\uff08MARCH\uff09 <\/li>\n<li>\u585e\u5229\u5c3c\u7d22\u5355\u836f\u6cbb\u7597\u96be\u6cbb\u590d\u53d1\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5728\u4e2d\u56fd\u5927\u9646\u5f00\u5c55(SEARCH) <\/li>\n<li>\u585e\u5229\u5c3c\u7d22\u8054\u5408R-GDP\u6cbb\u7597\u96be\u6cbb\u590d\u53d1\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u7684III\u671f\u5168\u7403\u591a\u4e2d\u5fc3\u4e34\u5e8a\u8bd5\u9a8c\u5728\u4e2d\u56fd\u5927\u9646\u5f00\u5c55(XPORT-DLBCL-030) <\/li>\n<li>\u585e\u5229\u5c3c\u7d22\u5355\u836f\u6cbb\u7597\u5b50\u5bab\u5185\u819c\u764c\u7684III\u671f\u5168\u7403\u591a\u4e2d\u5fc3\u4e34\u5e8a\u8bd5\u9a8c\u5728\u4e2d\u56fd\u5927\u9646\u5f00\u5c55(SINEDO) <\/li>\n<li>\u585e\u5229\u5c3c\u7d22\u5355\u836f\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5728\u4e2d\u56fd\u5927\u9646\u5f00\u5c55(TRUMP) <\/li>\n<li>\u585e\u5229\u5c3c\u7d22\u8054\u5408ICE\/GEMOX\u6cbb\u7597\u96be\u6cbb\u590d\u53d1\u5916\u5468T\u7ec6\u80de\u548cNK\/T\u7ec6\u80de\u6dcb\u5df4\u7624I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5728\u4e2d\u56fd\u5927\u9646\u5f00\u5c55(TOUCH) <\/li>\n<li>\u585e\u5229\u5c3c\u7d22\u8054\u5408\u787c\u66ff\u4f50\u7c73\u3001\u5730\u585e\u7c73\u677e\u6cbb\u7597\u96be\u6cbb\u590d\u53d1\u591a\u53d1\u6027\u9aa8\u9ad3\u7624III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5728\u4e2d\u56fd\u5927\u9646\u5f00\u5c55\uff08BENCH\uff09 <\/li>\n<li>\u585e\u5229\u5c3c\u7d22\u5355\u836f\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684\u9aa8\u9ad3\u7ea4\u7ef4\u5316\u7684II\u671f\u5168\u7403\u591a\u4e2d\u5fc3\u4e34\u5e8a\u8bd5\u9a8c\u5728\u4e2d\u56fd\u5927\u9646\u5f00\u5c55\uff08XPORT-MF-035\uff09 <\/li>\n<li>Eltanexor\u5355\u836f\u6cbb\u7597\u53bb\u7532\u57fa\u5316\u836f\u7269\u6cbb\u7597\u5931\u8d25\u7684\u4e2d\u9ad8\u5371\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\u7684I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5728\u4e2d\u56fd\u5927\u9646\u5f00\u5c55\uff08HATCH\uff09<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<div>\n<table id=\"convertedTable7f91\" cellspacing=\"0\" cellpadding=\"0\" border=\"1\" class=\"prntblns\">\n<tbody>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[1] \u6765\u81ea\uff1a\u7ba1\u6960\u6960\u7b49. \u80bf\u7624\u9632\u6cbb\u7814\u7a76. 2019;46(4):547-550.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[2] \u6765\u81ea\uff1aPUPH and Peking University Health Science Centre\u2019s unpublished data (have authorized). Based on UEBMI and URBMI database, from 2012 to 2016 in Chinese 23 provinces.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[3] \u6765\u81ea\uff1aJin Lu, et al. Blood Cancer J. 2014 Aug 15;4:e239.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[4] 2018 \u5e74\u6700\u65b0\u300a\u5168\u7403\u764c\u75c7\u62a5\u544a\u300b<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[5] \u674e\u5c0f\u79cb, \u674e\u7518\u5730, \u9ad8\u5b50\u82ac,\u7b49. \u4e2d\u56fd\u6dcb\u5df4\u7624\u4e9a\u578b\u5206\u5e03:\u56fd\u5185\u591a\u4e2d\u5fc3\u6027\u75c5\u4f8b10002\u4f8b\u5206\u6790[J]. \u8bca\u65ad\u5b66\u7406\u8bba\u4e0e\u5b9e\u8df5, 2012(2):111-115.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder0\">\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u4e0a\u6d77\u548c\u9999\u6e2f2021\u5e747\u670819\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 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\u585e\u5229\u5c3c\u7d22\u5355\u836f\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684\u9aa8\u9ad3\u7ea4\u7ef4\u5316\u7684II\u671f\u5168\u7403\u591a\u4e2d\u5fc3\u4e34\u5e8a\u8bd5\u9a8c\u5728\u4e2d\u56fd\u5927\u9646\u5f00\u5c55\uff08XPORT-MF-035\uff09 Eltanexor\u5355\u836f\u6cbb\u7597\u53bb\u7532\u57fa\u5316\u836f\u7269\u6cbb\u7597\u5931\u8d25\u7684\u4e2d\u9ad8\u5371\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\u7684I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5728\u4e2d\u56fd\u5927\u9646\u5f00\u5c55\uff08HATCH\uff09 &nbsp; [1] \u6765\u81ea\uff1a\u7ba1\u6960\u6960\u7b49. \u80bf\u7624\u9632\u6cbb\u7814\u7a76. 2019;46(4):547-550. [2] \u6765\u81ea\uff1aPUPH and Peking University Health Science Centre\u2019s unpublished data (have authorized). 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