{"id":36233,"date":"2021-07-02T20:50:00","date_gmt":"2021-07-02T13:50:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021070220500036233"},"modified":"2021-07-03T21:39:32","modified_gmt":"2021-07-03T13:39:32","slug":"%e5%88%9b%e8%83%9c%e9%9b%86%e5%9b%a2%e5%ae%a3%e5%b8%83%e6%8a%97-claudin18-2-%e5%8d%95%e5%85%8b%e9%9a%86%e6%8a%97%e4%bd%93-tst001-%e9%a1%b9%e7%9b%ae%e6%9c%80%e6%96%b0%e8%bf%9b%e5%b1%95%e5%b9%b6","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021070220500036233","title":{"rendered":"\u521b\u80dc\u96c6\u56e2\u5ba3\u5e03\u6297 Claudin18.2 \u5355\u514b\u9686\u6297\u4f53 TST001 \u9879\u76ee\u6700\u65b0\u8fdb\u5c55\u5e76\u62a5\u544a TST001 \u5728\u80c3\u764c\u60a3\u8005\u4e2d\u7684\u65e9\u671f\u6297\u80bf\u7624\u6d3b\u6027"},"content":{"rendered":"

\u82cf\u5dde2021\u5e747\u67082\u65e5 \/\u7f8e\u901a\u793e\/ — \u521b\u80dc\u96c6\u56e2\uff0c\u4e00\u5bb6\u5177\u5907\u751f\u7269\u836f\u7814\u53d1\u3001\u4e34\u5e8a\u53ca\u5de5\u827a\u5f00\u53d1\u548c\u751f\u4ea7\u5168\u6d41\u7a0b\u6574\u5408\u80fd\u529b\u7684\u4e34\u5e8a\u9636\u6bb5\u7684\u56fd\u9645\u5316\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\u6b63\u5728\u8fdb\u884c\u7684 TST001 \uff08\u6297 Claudin18.2 \u5355\u514b\u9686\u6297\u4f53\uff09\u5242\u91cf\u722c\u5761<\/span>\u8bd5\u9a8c\u4e2d\u5df2\u7ecf\u89c2\u5bdf\u5230\u4ee4\u4eba\u5174\u594b\u7684\u80bf\u7624\u90e8\u5206\u7f13\u89e3\u3002<\/p>\n<\/p>\n

\u76ee\u524d TST001 \u6b63\u5728\u7f8e\u56fd\u548c\u4e2d\u56fd\u5f00\u5c55\u5242\u91cf\u722c\u5761\u7814\u7a76\u3002\u53e6\u5916\uff0c\u521b\u80dc\u96c6\u56e2\u5728 2021 \u5e74 4 \u6708\u548c 5 \u6708\u5206\u522b\u542f\u52a8\u4e86\u5728\u80c3\u764c\u75c5\u4eba\u4e2d\u4e0e\u4e8c\u7ebf\u548c\u4e00\u7ebf\u5316\u7597\u8054\u5408\u7684\u4e34\u5e8a\u7814\u7a76\u3002\u76ee\u524d\u4e00<\/span>\u5171\u5165\u7ec4\u4e86 40 \u591a\u4f8b\u75c5\u4eba\u3002\u73b0\u6709\u5242\u91cf\u6570\u636e\u8868\u660e TST001 \u4e0d\u7ba1\u662f\u5355\u836f\u6216\u8054\u5408\u5747\u662f\u5b89\u5168\u7684\u3002<\/p>\n

\u5728\u8fd9\u4e00\u7cfb\u5217\u7814\u7a76\u4e2d TST001 \u4e5f\u5c55\u793a\u4e86\u521d\u6b65\u7684\u4ee4\u4eba\u5174\u594b\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002 \u5728 TST001 \u5355\u836f\u5242\u91cf\u9012\u589e\u7814\u7a76\u4e2d\uff0c\u6839\u636e RECIST1.1 \u6807\u51c6\uff0c\u5728 6mg\/kg \u7684\u5242\u91cf\u7ec4\u7684\u4e09\u4e2a\u75c5\u4eba\u4e2d\u7684\u4e00\u540d\u63a5\u53d7\u8fc7\u591a\u7ebf\u6cbb\u7597\u5931\u8d25\u7684\u665a\u671f\u80c3\u764c\u60a3\u8005\u6cbb\u7597\u8fd1 6 \u5468\u540e\u8fbe\u5230\u90e8\u5206\u7f13\u89e3\uff0c\u80bf\u7624\u751f\u7269\u6807\u5fd7\u7269\u4e5f\u660e\u663e\u8fc5\u901f\u51cf\u5c11\u3002\u8be5\u60a3\u8005\u66fe\u63a5\u53d7\u591a\u7ebf\u5316\u7597\u3001PD-1 \u7597\u6cd5\u3001\u6297\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u6291\u5236\u5242\u6cbb\u7597\uff0c\u7ed3\u679c\u5747\u4ee5\u5931\u8d25\u544a\u7ec8\u3002\u53e6\u5916\uff0c\u6839\u636e RECIST1.1 \u6807\u51c6\uff0c\u5728 TST001 \u8054\u5408 CAPOX \u6cbb\u7597\u4e00\u7ebf\u80c3\u764c\u7684\u7814\u7a76\u4e2d\uff0c\u7b2c\u4e00\u4e2a\u5242\u91cf\u7ec4\u4e2d\u7684\u4e00\u540d\u60a3\u8005\u5728\u6cbb\u7597 6 \u5468\u540e\u83b7\u5f97\u4e86\u90e8\u5206\u7f13\u89e3\u3002<\/p>\n

\u57fa\u4e8e\u4e0a\u8ff0\u6570\u636e\uff0c\u521b\u80dc\u96c6\u56e2\u8ba1\u5212\u7ee7\u7eed\u5b8c\u6210\u73b0\u884c\u7684\u5242\u91cf\u722c\u5761\u7814\u7a76\u5e76\u5728 2021 \u5e74\u7b2c\u56db\u5b63\u5ea6\u542f\u52a8\u5bf9 Claudin18.2 \u8868\u8fbe\u7684\u5b9e\u4f53\u7624\uff08\u5305\u62ec\u80c3\u764c\u3001\u80f0\u817a\u764c\u7b49\u5176\u4ed6\u80bf\u7624\uff09\u7684\u4e34\u5e8a 2a \u671f\u5355\u836f\u7814\u7a76\uff0c\u5c06\u6765\u4f1a\u5728\u533b\u5b66\u4f1a\u8bae\u4e0a\u516c\u5e03 TST001 \u8be6\u7ec6\u7684\u4e34\u5e8a 1a \u671f\u7814\u7a76\u6570\u636e\u3002<\/p>\n

\u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662\u526f\u9662\u957f\uff0c\u6d88\u5316\u80bf\u7624\u5185\u79d1\u4e3b\u4efb\u6c88\u7433\u6559\u6388\u8ba4\u4e3a\uff1a\u201c\u8fd1\u671f\uff0cClaudin18.2 \u5df2\u6210\u4e3a\u80c3\u764c\u6cbb\u7597\u9886\u57df\u7684\u4e00\u4e2a\u4ee4\u4eba\u5174\u594b\u7684\u9776\u70b9\u3002TST001 \u5728\u5242\u91cf\u722c\u5347\u8fc7\u7a0b\u4e2d\u53d1\u73b0 6mg\/kg \u7684\u5242\u91cf\u5728\u60a3\u8005\u4f53\u5185\u4ea7\u751f\u663e\u8457\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u8fd9\u8868\u660e TST001 \u662f\u4e00\u4e2a\u5f88\u6709\u524d\u666f\u7684 Claudin18.2 \u9776\u5411\u836f\u7269\u3002\u5f88\u671f\u5f85 TST001 \u5728\u66f4\u9ad8\u5242\u91cf\u4ee5\u53ca\u8054\u5408\u7528\u836f\u4e2d\uff0c\u9488\u5bf9\u9ad8\u5ea6\u8868\u8fbe Claudin18.2 \u7684\u80c3\u764c\u83b7\u5f97\u66f4\u597d\u7684\u6cbb\u7597\u7ed3\u679c\u3002\u201d<\/p>\n

\u521b\u80dc\u96c6\u56e2\u5168\u7403\u7814\u53d1\u6267\u884c\u526f\u603b\u88c1\u517c<\/span>\u9996\u5e2d\u533b\u5b66\u5b98\u77f3\u660e\u535a\u58eb\u8868\u793a\uff1a\u201c\u4e00\u4e9b Claudin18.2 \u9ad8\u8868\u8fbe\u7684\u665a\u671f\u80c3\u764c\u60a3\u8005\u5728\u63a5\u53d7\u6240\u6709\u53ef\u7528\u7684\u80c3\u764c\u4e00\u7ebf\u3001\u4e8c\u7ebf\u3001\u4e09\u7ebf\u6807\u51c6\u7597\u6cd5\u5931\u8d25\u3002\u4f46\u4ece TST001 \u5355\u836f\u6cbb\u7597\u672b\u671f\u80c3\u764c\u4e34\u5e8a\u7814\u7a76\u4e2d\u6211\u4eec\u89c2\u5bdf\u5230\uff0c\u8fd9\u4e9b\u591a\u7ebf\u6cbb\u7597\u5931\u8d25\u7684\u60a3\u8005\u4e2d\u51fa\u73b0\u4e86\u4ee4\u4eba\u5174\u594b\u7684\u7597\u6548\u4fe1\u53f7\u3002\u6b64\u5916\uff0c\u6211\u4eec\u6b63\u5728\u5feb\u901f\u63a8\u8fdb TST001 \u4e0e\u5316\u7597\u548c\u514d\u75ab\u7597\u6cd5\u76f8\u7ed3\u5408\u6cbb\u7597\u8f83\u65e9\u671f\u80c3\u764c\u7684\u7814\u7a76\u8fdb\u7a0b\u3002TST001 \u5355\u836f\u6cbb\u7597\u4ee5\u53ca\u4e0e\u5316\u836f\u8054\u5408\u7528\u836f\u7684\u521d\u6b65\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u8868\u660e\uff0cTST001 \u5bf9\u6cbb\u7597\u80bf\u7624\u8868\u8fbe Claudin18.2 \u7684\u60a3\u8005\u5177\u6709\u5f88\u5927\u7684\u6f5c\u529b\u3002\u6211\u671f\u5f85\u672a\u6765\u80fd\u6709\u66f4\u591a\u7684\u4e34\u5e8a\u6570\u636e\u8fdb\u4e00\u6b65\u8bc1\u5b9e TST001 \u7684\u7597\u6548\u548c\u5b89\u5168\u6027\uff0c\u5e76\u52a0\u5feb\u6211\u4eec\u9488\u5bf9 Claudin18.2 \u7684\u591a\u79cd\u80bf\u7624\u7c7b\u578b\u7684\u4e34\u5e8a\u5f00\u53d1\u9879\u76ee\u3002\u201d<\/p>\n

\u5173\u4e8e TST001<\/b><\/p>\n

TST001 \u662f\u7ee7 Zolbetuximab (IMAB362) \u4e4b\u540e\uff0c\u5728\u5168\u7403\u8303\u56f4\u5185\u5f00\u53d1\u7684\u7b2c\u4e8c\u4e2a Claudin18.2 \u9776\u5411\u6297\u4f53\u6cbb\u7597\u5019\u9009\u836f\u7269\u3002TST001 \u662f\u4e00\u79cd\u9ad8\u4eb2\u548c\u529b\u7684\u9776\u5411 Claudin18.2 \u7684\u91cd\u7ec4\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\uff0c\u7531\u521b\u80dc\u96c6\u56e2\u901a\u8fc7\u5176\u72ec\u7acb\u5f00\u53d1\u7684\u514d\u75ab\u8010\u53d7\u7a81\u7834 (IMTB) \u6280\u672f\u5e73\u53f0\u5f00\u53d1\u3002TST001 \u53ef\u901a\u8fc7\u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u6bd2\u6027 (ADCC) \u548c\u8865\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u6bd2\u6027 (CDC) \u673a\u5236\u6740\u6b7b\u8868\u8fbe Claudin18.2 \u7684\u80bf\u7624\u7ec6\u80de\u3002\u5229\u7528\u5148\u8fdb\u7684\u751f\u7269\u52a0\u5de5\u6280\u672f\uff0cTST001 \u7684\u5ca9\u85fb\u7cd6\u542b\u91cf\u5728\u751f\u4ea7\u8fc7\u7a0b\u4e2d\u5927\u5927\u964d\u4f4e\uff0c\u8fdb\u4e00\u6b65\u589e\u5f3a\u4e86 TST001 \u7684 ADCC \u4ecb\u5bfc\u7684\u80bf\u7624\u6740\u4f24\u6d3b\u6027\u3002\u5728\u5c0f\u9f20\u5f02\u79cd\u79fb\u690d\u5b9e\u9a8c\u4e2d\uff0cTST001 \u663e\u793a\u51fa\u6bd4 IMAB362 \u7c7b\u4f3c\u7269\u66f4\u5f3a\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u81ea 2020 \u5e74 7 \u6708\u4ee5\u6765\uff0c\u4e2d\u56fd\u548c\u7f8e\u56fd\u5747\u4e00\u76f4\u5728\u8fdb\u884c TST001 \u7684\u4e34\u5e8a\u8bd5\u9a8c (NCT04396821, NCT04495296\/CTR20201281)\u3002<\/p>\n

\u5173\u4e8e\u521b\u80dc\u96c6\u56e2<\/b><\/p>\n

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\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8bf7\u8054\u7cfb<\/p>\n

\u5a92\u4f53\u8054\u7cfb\uff1apr@transcenta.com<\/a>
\u5546\u52a1\u5408\u4f5c\uff1abd@transcenta.com<\/a> <\/p>\n

\u76f8\u5173\u94fe\u63a5 :<\/p>\n

http:\/\/www.transcenta.com<\/p>\n","protected":false},"excerpt":{"rendered":"

\u82cf\u5dde2021\u5e747\u67082\u65e5 \/\u7f8e\u901a\u793e\/ — \u521b\u80dc\u96c6\u56e2\uff0c\u4e00\u5bb6\u5177\u5907\u751f\u7269\u836f\u7814\u53d1\u3001\u4e34\u5e8a\u53ca\u5de5\u827a\u5f00\u53d1\u548c\u751f\u4ea7\u5168\u6d41\u7a0b\u6574\u5408\u80fd\u529b\u7684\u4e34\u5e8a\u9636\u6bb5\u7684\u56fd\u9645\u5316\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\u6b63\u5728\u8fdb\u884c\u7684 TST001 \uff08\u6297 Claudin18.2 \u5355\u514b\u9686\u6297\u4f53\uff09\u5242\u91cf\u722c\u5761\u8bd5\u9a8c\u4e2d\u5df2\u7ecf\u89c2\u5bdf\u5230\u4ee4\u4eba\u5174\u594b\u7684\u80bf\u7624\u90e8\u5206\u7f13\u89e3\u3002 \u76ee\u524d TST001 \u6b63\u5728\u7f8e\u56fd\u548c\u4e2d\u56fd\u5f00\u5c55\u5242\u91cf\u722c\u5761\u7814\u7a76\u3002\u53e6\u5916\uff0c\u521b\u80dc\u96c6\u56e2\u5728 2021 \u5e74 4 \u6708\u548c 5 \u6708\u5206\u522b\u542f\u52a8\u4e86\u5728\u80c3\u764c\u75c5\u4eba\u4e2d\u4e0e\u4e8c\u7ebf\u548c\u4e00\u7ebf\u5316\u7597\u8054\u5408\u7684\u4e34\u5e8a\u7814\u7a76\u3002\u76ee\u524d\u4e00\u5171\u5165\u7ec4\u4e86 40 \u591a\u4f8b\u75c5\u4eba\u3002\u73b0\u6709\u5242\u91cf\u6570\u636e\u8868\u660e TST001 \u4e0d\u7ba1\u662f\u5355\u836f\u6216\u8054\u5408\u5747\u662f\u5b89\u5168\u7684\u3002 \u5728\u8fd9\u4e00\u7cfb\u5217\u7814\u7a76\u4e2d TST001 \u4e5f\u5c55\u793a\u4e86\u521d\u6b65\u7684\u4ee4\u4eba\u5174\u594b\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002 \u5728 TST001 \u5355\u836f\u5242\u91cf\u9012\u589e\u7814\u7a76\u4e2d\uff0c\u6839\u636e RECIST1.1 \u6807\u51c6\uff0c\u5728 6mg\/kg \u7684\u5242\u91cf\u7ec4\u7684\u4e09\u4e2a\u75c5\u4eba\u4e2d\u7684\u4e00\u540d\u63a5\u53d7\u8fc7\u591a\u7ebf\u6cbb\u7597\u5931\u8d25\u7684\u665a\u671f\u80c3\u764c\u60a3\u8005\u6cbb\u7597\u8fd1 6 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\u8868\u8fbe\u7684\u5b9e\u4f53\u7624\uff08\u5305\u62ec\u80c3\u764c\u3001\u80f0\u817a\u764c\u7b49\u5176\u4ed6\u80bf\u7624\uff09\u7684\u4e34\u5e8a 2a \u671f\u5355\u836f\u7814\u7a76\uff0c\u5c06\u6765\u4f1a\u5728\u533b\u5b66\u4f1a\u8bae\u4e0a\u516c\u5e03 TST001 \u8be6\u7ec6\u7684\u4e34\u5e8a 1a \u671f\u7814\u7a76\u6570\u636e\u3002 \u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662\u526f\u9662\u957f\uff0c\u6d88\u5316\u80bf\u7624\u5185\u79d1\u4e3b\u4efb\u6c88\u7433\u6559\u6388\u8ba4\u4e3a\uff1a\u201c\u8fd1\u671f\uff0cClaudin18.2 \u5df2\u6210\u4e3a\u80c3\u764c\u6cbb\u7597\u9886\u57df\u7684\u4e00\u4e2a\u4ee4\u4eba\u5174\u594b\u7684\u9776\u70b9\u3002TST001 \u5728\u5242\u91cf\u722c\u5347\u8fc7\u7a0b\u4e2d\u53d1\u73b0 6mg\/kg \u7684\u5242\u91cf\u5728\u60a3\u8005\u4f53\u5185\u4ea7\u751f\u663e\u8457\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u8fd9\u8868\u660e TST001 \u662f\u4e00\u4e2a\u5f88\u6709\u524d\u666f\u7684 Claudin18.2 \u9776\u5411\u836f\u7269\u3002\u5f88\u671f\u5f85 TST001 \u5728\u66f4\u9ad8\u5242\u91cf\u4ee5\u53ca\u8054\u5408\u7528\u836f\u4e2d\uff0c\u9488\u5bf9\u9ad8\u5ea6\u8868\u8fbe Claudin18.2 \u7684\u80c3\u764c\u83b7\u5f97\u66f4\u597d\u7684\u6cbb\u7597\u7ed3\u679c\u3002\u201d \u521b\u80dc\u96c6\u56e2\u5168\u7403\u7814\u53d1\u6267\u884c\u526f\u603b\u88c1\u517c\u9996\u5e2d\u533b\u5b66\u5b98\u77f3\u660e\u535a\u58eb\u8868\u793a\uff1a\u201c\u4e00\u4e9b Claudin18.2 \u9ad8\u8868\u8fbe\u7684\u665a\u671f\u80c3\u764c\u60a3\u8005\u5728\u63a5\u53d7\u6240\u6709\u53ef\u7528\u7684\u80c3\u764c\u4e00\u7ebf\u3001\u4e8c\u7ebf\u3001\u4e09\u7ebf\u6807\u51c6\u7597\u6cd5\u5931\u8d25\u3002\u4f46\u4ece TST001 \u5355\u836f\u6cbb\u7597\u672b\u671f\u80c3\u764c\u4e34\u5e8a\u7814\u7a76\u4e2d\u6211\u4eec\u89c2\u5bdf\u5230\uff0c\u8fd9\u4e9b\u591a\u7ebf\u6cbb\u7597\u5931\u8d25\u7684\u60a3\u8005\u4e2d\u51fa\u73b0\u4e86\u4ee4\u4eba\u5174\u594b\u7684\u7597\u6548\u4fe1\u53f7\u3002\u6b64\u5916\uff0c\u6211\u4eec\u6b63\u5728\u5feb\u901f\u63a8\u8fdb TST001 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