{"id":35396,"date":"2021-06-25T14:30:00","date_gmt":"2021-06-25T07:30:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021062514300035396"},"modified":"2021-06-26T21:37:18","modified_gmt":"2021-06-26T13:37:18","slug":"%e7%a0%94%e7%a9%b6%e8%a1%a8%e6%98%8e%e5%ba%94%e4%b8%96%e7%94%9f%e7%89%a9%e6%97%97%e4%b8%8bfak%e6%8a%91%e5%88%b6%e5%89%82%ef%bc%88in10018%ef%bc%89%e8%83%bd%e5%85%8b%e6%9c%8dkras-g12c%e6%8a%91%e5%88%b6","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021062514300035396","title":{"rendered":"\u7814\u7a76\u8868\u660e\u5e94\u4e16\u751f\u7269\u65d7\u4e0bFAK\u6291\u5236\u5242\uff08IN10018\uff09\u80fd\u514b\u670dKRAS G12C\u6291\u5236\u5242\u6240\u5bfc\u81f4\u7684\u8010\u836f\uff0c\u548cKRAS G12C\u6291\u5236\u5242\u8054\u5408\u6709\u534f\u540c\u6297\u764c\u4f5c\u7528"},"content":{"rendered":"<table border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><img decoding=\"async\" title=\"logo\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/InxMed_Logo-2.jpg\" alt=\"\" width=\"118\" border=\"0\" hspace=\"0\" vspace=\"0\" \/><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><p>\u4e0a\u6d772021\u5e746\u670825\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u5e94\u4e16\u751f\u7269\u79d1\u6280\uff08\u4e0a\u6d77\uff09\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0&ldquo;\u5e94\u4e16\u751f\u7269&rdquo;\u6216&ldquo;\u516c\u53f8&rdquo;\uff09\u4e0e\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u745e\u91d1\u533b\u9662\u5408\u4f5c\u5728Advanced Science\u4e0a\u5728\u7ebf\u53d1\u8868\u4e86\u9898\u4e3a&ldquo;Focal Adhesion Kinase (FAK) Inhibition Synergizes with KRAS G12C Inhibitors in Treating Cancer through the Regulation of the FAK&ndash;YAP Signaling&rdquo;\u7684\u7814\u7a76\u8bba\u6587\uff0c\u8be5\u7814\u7a76\u53d1\u73b0\u80bf\u7624\u7ec6\u80de\u5728KRAS G12C\u6291\u5236\u5242\u4f5c\u7528\u4e0b\u53ef\u901a\u8fc7\u8bf1\u5bfc\u5c40\u90e8\u9ecf\u7740\u6591\u6fc0\u9176\uff08FAK\uff09\u6d3b\u6027\u4ea7\u751f\u8010\u836f\uff0c\u7531\u6b64\u5f71\u54cd\u7597\u6548\uff0c\u5e76\u8bc1\u5b9e\u4e86\u8054\u5408FAK\u6291\u5236\u5242\uff08IN10018\uff09\u548cKRAS G12C\u6291\u5236\u5242\u7684\u6cbb\u7597\u7b56\u7565\u80fd\u5b9e\u73b0\u534f\u540c\u6297\u764c\u4f5c\u7528\uff0c\u53ef\u4ee5\u540c\u65f6\u964d\u4f4e\u5176\u8010\u836f\u53cd\u5e94\u4f7f\u6297\u764c\u4f5c\u7528\u66f4\u52a0\u6301\u4e45\u3002\uff08\u539f\u6587\u94fe\u63a5<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/advs.202100250\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/advs.202100250<\/a>\uff09<span id=\"spanHghlt6163\">\u3002<\/span> &nbsp;<\/p>\n<div id=\"DivAssetPlaceHolder1750\" class=\"PRN_ImbeddedAssetReference\">&nbsp;<\/div>\n<p>FAK\u662f\u5305\u542bKRAS\u5728\u5185\u7684RAS\u4fe1\u53f7\u901a\u8def\u7684\u4e0b\u6e38\u57fa\u56e0\uff0cFAK\u6291\u5236\u5242\u5728\u591a\u4e2a\u52a8\u7269\u6a21\u578b\u4e2d\u663e\u793a\u6297KRAS\u7a81\u53d8\u578b\u764c\u75c7\u6548\u679c\u3002FAK\u4fe1\u53f7\u7684\u6fc0\u6d3b\u548c\u5bfc\u81f4\u5316\u7597\u836f\u7269\u53ca\u9776\u5411\u836f\u7269\u8010\u836f\u76f8\u5173\u3002\u672c\u9879\u7814\u7a76\u53d1\u73b0FAK\u4fe1\u53f7\u901a\u8def\u5728KRAS G12C\u6291\u5236\u5242\u7684\u4f5c\u7528\u4e0b\u4f1a\u88ab\u6fc0\u6d3b\u3002KRAS G12C\u6291\u5236\u5242\uff08AMG510\u6216MRTX849\uff09\u4e0e\u4e34\u5e8a\u9636\u6bb5\u7684\u5c0f\u5206\u5b50FAK\u6291\u5236\u5242IN10018\u8054\u5408\u4f7f\u7528\uff0c\u5bf9KRAS G12C\u7a81\u53d8\u764c\u75c7\u7684\u591a\u4e2a\u764c\u7ec6\u80de\u7cfb\u3001CDX\u548cPDX\u6a21\u578b\u4ea7\u751f\u4e86\u534f\u540c\u7684\u6297\u764c\u6548\u679c\u3002\u8fdb\u4e00\u6b65\u7684\u673a\u5236\u5b66\u7814\u7a76\u53d1\u73b0\uff0c\u5f02\u5e38\u6fc0\u6d3b\u7684FAK-YAP\u901a\u8def\u662fKRAS G12C\u6291\u5236\u5242\u4ea7\u751f\u8010\u836f\u4f5c\u7528\u7684\u91cd\u8981\u539f\u56e0\u3002\u8be5\u7814\u7a76\u4e3aKRAS G12C\u7a81\u53d8\u7684\u4e34\u5e8a\u60a3\u8005\u957f\u671f\u83b7\u76ca\u63d0\u4f9b\u4e86\u65b0\u7684\u5408\u7528\u7b56\u7565\u3002<\/p>\n<p>\u5e94\u4e16\u751f\u7269\u521b\u59cb\u4eba\u517c\u9996\u5e2d\u6267\u884c\u5b98\u738b\u5728\u742a\u535a\u58eb\u8868\u793a\uff1a&ldquo;\u8fd9\u9879\u7814\u7a76\u663e\u793aFAK\u6291\u5236\u5242\uff08IN10018\uff09\u80fd\u514b\u670dKRAS G12C\u6291\u5236\u5242\u6240\u5bfc\u81f4\u7684\u8010\u836f\uff0c\u4e3a\u6539\u5584KRAS G12C\u7a81\u53d8\u764c\u75c7\u7684\u6cbb\u7597\u6548\u679c\u63d0\u4f9b\u53ef\u80fd\u3002FAK\u6291\u5236\u5242(IN10018) \u76ee\u524d\u5df2\u5728\u7f8e\u56fd\u3001\u6fb3\u6d32\u548c\u4e2d\u56fd\u5f00\u5c55\u4e09\u9879\u4e34\u5e8a\u7814\u7a76\uff0c\u7814\u7a76\u8868\u660eIN10018\u7684\u5b89\u5168\u6027\u53ef\u63a5\u53d7\uff0c\u89c2\u5bdf\u826f\u597d\u7684\u6297\u80bf\u7624\u7597\u6548\u4fe1\u53f7\u3002\u5e94\u4e16\u751f\u7269\u5c06\u5145\u5206\u8fd0\u7528\u9ad8\u6548\u7684\u8f6c\u5316\u533b\u5b66\u548c\u5168\u7403\u4e34\u5e8a\u5f00\u53d1\u80fd\u529b\uff0c\u5168\u529b\u52a0\u901f\u63a8\u8fdb\u4e34\u5e8a\u9879\u76ee\u8fdb\u5c55\uff0c\u65e9\u65e5\u4e3a\u60a3\u8005\u63d0\u4f9b\u6709\u6548\u7684\u6cbb\u7597\u9009\u62e9\u65b9\u6848\u3002&rdquo;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e0a\u6d772021\u5e746\u670825\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u5e94\u4e16\u751f\u7269\u79d1\u6280\uff08\u4e0a\u6d77\uff09\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0&ldquo;\u5e94\u4e16\u751f\u7269&rdquo;\u6216&ldquo;\u516c\u53f8&rdquo;\uff09\u4e0e\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u745e\u91d1\u533b\u9662\u5408\u4f5c\u5728Advanced Science\u4e0a\u5728\u7ebf\u53d1\u8868\u4e86\u9898\u4e3a&ldquo;Focal Adhesion Kinase (FAK) Inhibition Synergizes with KRAS G12C Inhibitors in Treating Cancer through the Regulation of the FAK&ndash;YAP Signaling&rdquo;\u7684\u7814\u7a76\u8bba\u6587\uff0c\u8be5\u7814\u7a76\u53d1\u73b0\u80bf\u7624\u7ec6\u80de\u5728KRAS G12C\u6291\u5236\u5242\u4f5c\u7528\u4e0b\u53ef\u901a\u8fc7\u8bf1\u5bfc\u5c40\u90e8\u9ecf\u7740\u6591\u6fc0\u9176\uff08FAK\uff09\u6d3b\u6027\u4ea7\u751f\u8010\u836f\uff0c\u7531\u6b64\u5f71\u54cd\u7597\u6548\uff0c\u5e76\u8bc1\u5b9e\u4e86\u8054\u5408FAK\u6291\u5236\u5242\uff08IN10018\uff09\u548cKRAS G12C\u6291\u5236\u5242\u7684\u6cbb\u7597\u7b56\u7565\u80fd\u5b9e\u73b0\u534f\u540c\u6297\u764c\u4f5c\u7528\uff0c\u53ef\u4ee5\u540c\u65f6\u964d\u4f4e\u5176\u8010\u836f\u53cd\u5e94\u4f7f\u6297\u764c\u4f5c\u7528\u66f4\u52a0\u6301\u4e45\u3002\uff08\u539f\u6587\u94fe\u63a5https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/advs.202100250\uff09\u3002 &nbsp; &nbsp; FAK\u662f\u5305\u542bKRAS\u5728\u5185\u7684RAS\u4fe1\u53f7\u901a\u8def\u7684\u4e0b\u6e38\u57fa\u56e0\uff0cFAK\u6291\u5236\u5242\u5728\u591a\u4e2a\u52a8\u7269\u6a21\u578b\u4e2d\u663e\u793a\u6297KRAS\u7a81\u53d8\u578b\u764c\u75c7\u6548\u679c\u3002FAK\u4fe1\u53f7\u7684\u6fc0\u6d3b\u548c\u5bfc\u81f4\u5316\u7597\u836f\u7269\u53ca\u9776\u5411\u836f\u7269\u8010\u836f\u76f8\u5173\u3002\u672c\u9879\u7814\u7a76\u53d1\u73b0FAK\u4fe1\u53f7\u901a\u8def\u5728KRAS G12C\u6291\u5236\u5242\u7684\u4f5c\u7528\u4e0b\u4f1a\u88ab\u6fc0\u6d3b\u3002KRAS G12C\u6291\u5236\u5242\uff08AMG510\u6216MRTX849\uff09\u4e0e\u4e34\u5e8a\u9636\u6bb5\u7684\u5c0f\u5206\u5b50FAK\u6291\u5236\u5242IN10018\u8054\u5408\u4f7f\u7528\uff0c\u5bf9KRAS G12C\u7a81\u53d8\u764c\u75c7\u7684\u591a\u4e2a\u764c\u7ec6\u80de\u7cfb\u3001CDX\u548cPDX\u6a21\u578b\u4ea7\u751f\u4e86\u534f\u540c\u7684\u6297\u764c\u6548\u679c\u3002\u8fdb\u4e00\u6b65\u7684\u673a\u5236\u5b66\u7814\u7a76\u53d1\u73b0\uff0c\u5f02\u5e38\u6fc0\u6d3b\u7684FAK-YAP\u901a\u8def\u662fKRAS G12C\u6291\u5236\u5242\u4ea7\u751f\u8010\u836f\u4f5c\u7528\u7684\u91cd\u8981\u539f\u56e0\u3002\u8be5\u7814\u7a76\u4e3aKRAS G12C\u7a81\u53d8\u7684\u4e34\u5e8a\u60a3\u8005\u957f\u671f\u83b7\u76ca\u63d0\u4f9b\u4e86\u65b0\u7684\u5408\u7528\u7b56\u7565\u3002 \u5e94\u4e16\u751f\u7269\u521b\u59cb\u4eba\u517c\u9996\u5e2d\u6267\u884c\u5b98\u738b\u5728\u742a\u535a\u58eb\u8868\u793a\uff1a&ldquo;\u8fd9\u9879\u7814\u7a76\u663e\u793aFAK\u6291\u5236\u5242\uff08IN10018\uff09\u80fd\u514b\u670dKRAS G12C\u6291\u5236\u5242\u6240\u5bfc\u81f4\u7684\u8010\u836f\uff0c\u4e3a\u6539\u5584KRAS G12C\u7a81\u53d8\u764c\u75c7\u7684\u6cbb\u7597\u6548\u679c\u63d0\u4f9b\u53ef\u80fd\u3002FAK\u6291\u5236\u5242(IN10018) \u76ee\u524d\u5df2\u5728\u7f8e\u56fd\u3001\u6fb3\u6d32\u548c\u4e2d\u56fd\u5f00\u5c55\u4e09\u9879\u4e34\u5e8a\u7814\u7a76\uff0c\u7814\u7a76\u8868\u660eIN10018\u7684\u5b89\u5168\u6027\u53ef\u63a5\u53d7\uff0c\u89c2\u5bdf\u826f\u597d\u7684\u6297\u80bf\u7624\u7597\u6548\u4fe1\u53f7\u3002\u5e94\u4e16\u751f\u7269\u5c06\u5145\u5206\u8fd0\u7528\u9ad8\u6548\u7684\u8f6c\u5316\u533b\u5b66\u548c\u5168\u7403\u4e34\u5e8a\u5f00\u53d1\u80fd\u529b\uff0c\u5168\u529b\u52a0\u901f\u63a8\u8fdb\u4e34\u5e8a\u9879\u76ee\u8fdb\u5c55\uff0c\u65e9\u65e5\u4e3a\u60a3\u8005\u63d0\u4f9b\u6709\u6548\u7684\u6cbb\u7597\u9009\u62e9\u65b9\u6848\u3002&rdquo;&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2021062514300035396\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":35399,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-35396","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/35396","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=35396"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/35396\/revisions"}],"predecessor-version":[{"id":35398,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/35396\/revisions\/35398"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/35399"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=35396"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=35396"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=35396"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}