{"id":35047,"date":"2021-06-23T14:43:00","date_gmt":"2021-06-23T07:43:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021062314430035047"},"modified":"2021-06-23T21:39:26","modified_gmt":"2021-06-23T13:39:26","slug":"eha-2021-%e9%99%86%e9%81%93%e5%9f%b9%e5%8c%bb%e5%ad%a6%e5%9b%a2%e9%98%9f%e6%9c%80%e6%96%b0%e7%a0%94%e7%a9%b6%e6%88%90%e6%9e%9c%e5%86%8d%e6%ac%a1%e4%ba%ae%e7%9b%b8%e4%b8%96%e7%95%8c%e8%88%9e","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021062314430035047","title":{"rendered":"EHA 2021 &#8212; \u9646\u9053\u57f9\u533b\u5b66\u56e2\u961f\u6700\u65b0\u7814\u7a76\u6210\u679c\u518d\u6b21\u4eae\u76f8\u4e16\u754c\u821e\u53f0"},"content":{"rendered":"<p><p>\u5317\u4eac2021\u5e746\u670823\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 2021\u5e746\u67089-17\u65e5\uff0c\u7b2c26\u5c4a\u6b27\u6d32\u8840\u6db2\u5b66\u534f\u4f1a\uff08EHA\uff09\u5e74\u4f1a\u5c06\u5728\u7ebf\u4e0a\u5982\u671f\u53ec\u5f00\uff0c\u4f5c\u4e3a\u6b27\u6d32\u8840\u6db2\u5b66\u9886\u57df<span id=\"spanHghlt19b6\">\u89c4\u6a21\u6700\u5927<\/span>\u7684\u56fd\u9645\u6027\u4f1a\u8bae\uff0c\u6bcf\u5e74\u5438\u5f15\u6765\u81ea\u5168\u7403100\u591a\u4e2a\u56fd\u5bb6\u76841\u4e07\u591a\u540d\u4e13\u4e1a\u4eba\u58eb\u4e0e\u4f1a\uff0c\u5206\u4eab\u5168\u7403\u6700\u524d\u6cbf\u7684\u7814\u7a76\u8fdb\u5c55\u548c\u7a81\u7834\u6027\u4e34\u5e8a\u6570\u636e\u3002<\/p>\n<p>\u968f\u7740\u6211\u56fd\u8840\u6db2\u80bf\u7624\u76f8\u5173\u7814\u7a76\u7684\u5feb\u901f\u53d1\u5c55\uff0c\u4e2d\u56fd\u5728\u4e16\u754c\u8840\u6db2\u5b66\u9886\u57df\u4e5f\u53d1\u6325\u7740\u65e5\u76ca\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u672c\u5c4a\u5927\u4f1a\uff0c\u4e2d\u56fd\u4e13\u5bb6\u5171\u670916\u7bc7\u53e3\u5934\u53d1\u8a00\u5165\u56f4\uff0c\u9646\u9053\u57f9\u533b\u5b66\u56e2\u961f\u4ee51\u7bc7\u53e3\u5934\u62a5\u544a\uff08Oral\uff09\u548c7\u7bc7\u5899\u62a5\uff08Poster\uff09\u7684\u51fa\u8272\u6210\u7ee9\u518d\u6b21\u4eae\u76f8\u4e16\u754c\u821e\u53f0\uff0c\u5c24\u5176\u662f\u5728CAR-T\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\u9886\u57df\u53d6\u5f97\u7684\u5353\u8d8a\u7684\u4e34\u5e8a\u6548\u679c\uff0c\u83b7\u5f97\u56fd\u5185\u5916\u6743\u5a01\u4e13\u5bb6\u5b66\u8005\u7684\u9ad8\u5ea6\u8d5e\u8bb8\u3002<\/p>\n<p><b>ORAL<\/b><b>\uff1a<\/b><b>CAR-T<\/b><b>\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\u4e34\u5e8a\u7814\u7a76\u6210\u679c\u4e00\u9a91\u7edd\u5c18<\/b><\/p>\n<p>\u867d\u7136CAR-T \u7ec6\u80de\u7597\u6cd5\u5df2\u88ab\u8bc1\u5b9e\u662f\u6cbb\u7597\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u7684\u6709\u6548\u5de5\u5177\uff0c\u4f46\u5176\u5b89\u5168\u6027\u3001\u6297\u539f\u9003\u9038\u548c\u6301\u7eed\u7f13\u89e3\u65f6\u95f4\u7684\u6cbb\u7597\u6f5c\u529b\u53ef\u4ee5\u8fdb\u4e00\u6b65\u63d0\u9ad8\u3002\u6b64\u5916\uff0cCAR-T\u5728\u6cbb\u7597\u5b9e\u4f53\u7624\u4e0a\u7f3a\u4e4f\u8db3\u591f\u7684\u9776\u70b9\uff0c\u9650\u5236\u4e86\u5176\u5e7f\u6cdb\u5e94\u7528\uff0c\u5e76\u8feb\u5207\u9700\u8981\u4e00\u79cd\u65b0\u7684\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u3002<\/p>\n<p>\u7b2c\u4e00\u4f5c\u8005\uff1a\u6768\u541b\u82b3\uff1b\u901a\u8baf\u4f5c\u8005\uff1a\u9646\u4f69\u534e\uff0c\u6458\u8981\u53f7\uff1aS118<\/p>\n<p>A novel CD19\/CD20 dual synthetic T-cell receptor and antigen receptor (STAR) T cell therapy for refractory and relapsed (R\/R) B cell acute lymphoblastic leukemia (B-ALL)<\/p>\n<p>\u65b0\u578bCD19\/CD20\u53cc\u9776\u5411\u5408\u6210T\u7ec6\u80de\u53d7\u4f53\u548c\u6297\u539f\u53d7\u4f53\uff08STAR\uff09-T\u7ec6\u80de\u6cbb\u7597\u96be\u6cbb\/\u590d\u53d1B-ALL\u7684\u7814\u7a76<\/p>\n<p>\u534e\u590f\u82f1\u6cf0\u548c\u6e05\u534e\u5927\u5b66\u533b\u5b66\u9662\u5171\u540c\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u578b\u7684STAR-T\u7ec6\u80de\u7597\u6cd5\uff0cSTAR\u75312\u4e2a\u86cb\u767d\u8d28\u6a21\u5757\u7ec4\u6210\uff0c\u6bcf\u4e2a\u6a21\u5757\u5747\u5305\u542b\u6297\u4f53\u8f7b\u94fe\u6216\u91cd\u94fe\u53ef\u53d8\u533a\uff0c\u878d\u5408\u7684T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09a \u548c&nbsp;b\u94fe\u6052\u5b9a\u533a\u4e0eOX-40\u5171\u523a\u6fc0\u57df\u7ed3\u5408\uff0c\u901a\u8fc7\u81ea\u88c2\u89e3\u5f17\u6797\u86cb\u767d\u9176-p2A\u5e8f\u5217\u8fde\u63a5\u76842\u4e2a\u6a21\u5757\uff0c\u5141\u8bb8\u6a21\u5757\u901a\u8fc7\u86cb\u767d\u6c34\u89e3\u5206\u79bb\u548c\u91cd\u7ec4\u3002\u5728\u4e4b\u524dCD19\u5355\u9776\u70b9STAR-T\u6cbb\u7597R\/R B-ALL\u6210\u529f\u7684\u57fa\u7840\u4e0a\uff0c\u6b64\u6b21\u62a5\u544a\u4e86\u9996\u6b21\u7528\u5728\u4eba\u8eab\u4e0a\u7684CD19\/CD20\u53cc\u9776\u70b9STAR-T\u6cbb\u7597B-ALL\u7684I\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u3002<\/p>\n<p>\u7814\u7a76\u7eb3\u5165\u9646\u9053\u57f9\u533b\u966210\u4f8bCD19+\u6216\u8005CD19\/CD20+\u7684R\/R B-ALL\u60a3\u8005\uff0c9\u4f8b\u6210\u529f\u8f93\u6ce8CD19\/CD20 Dual STAR-T\u7ec6\u80de\uff0c2\u5468\u540e\u8bc4\u4f30\uff0c8\/9\uff0888.9%\uff09\u7684\u60a3\u8005\u8fbe\u5230\u4e86\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\uff08MRD\uff09\u9634\u6027\u7684\u5b8c\u5168\u7f13\u89e3\u3002<\/p>\n<p>\u5173\u4e8e\u6b64\u65b0\u4ea7\u54c1\u7684\u5b89\u5168\u6027\u4e0a\uff0c7\/9\uff0877.8%\uff09\u60a3\u8005\u51fa\u73b0\u4e86\u7ec6\u80de\u91ca\u653e\u7efc\u5408\u5f81\uff08CRS\uff09\uff0c\u4f46\u5747\u4e3a1\u7ea7\uff0c\u67092\u4f8b\u60a3\u8005\u51fa\u73b0\u4e86\u795e\u7ecf\u6bd2\u6027\uff081\u4f8b1\u7ea7\uff0c1\u4f8b3\u7ea7\uff09\uff0c\u5728\u6cbb\u7597\u540e\u5747\u53ef\u63a7\u3002<\/p>\n<p>\u9646\u4f69\u534e\u9662\u957f\uff1a\u76f8\u6bd4\u4f20\u7edf\u7684CAR\u7ed3\u6784\uff0cSTAR\u6700\u5927\u7a0b\u5ea6\u4e0a\u4fdd\u7559\u5929\u7136T\u7ec6\u80de\u53d7\u4f53\u4e0b\u6e38\u6d3b\u5316\u548c\u53cd\u9988\u53ca\u6740\u4f24\u4fe1\u53f7\uff0c\u5177\u6709\u5929\u7136\u53cc\u9776\u70b9\u3001\u5b89\u5168\u6027\u66f4\u597d\u3001\u65e0\u672c\u5e95\u6fc0\u6d3b\u3001\u7ec6\u80de\u8868\u578b\u66f4\u597d\u3001\u4e0d\u6613\u8017\u7aed\u3001\u7075\u654f\u5ea6\u9ad8\u3001\u7efc\u5408\u6740\u4f24\u6548\u679c\u66f4\u4f18\u7b49\u8bf8\u591a\u4f18\u52bf\u3002\u6211\u4eec\u62a5\u544a\u7684\u9996\u6b21\u5728\u4eba\u4f53\u7684\u4e34\u5e8aI\u671f\u7814\u7a76\u663e\u793a\u4e86\u5176\u5728\u8840\u6db2\u80bf\u7624\u4e0a\u7684\u6280\u672f\u53ef\u884c\u6027\u3001\u4e34\u5e8a\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u8f93\u6ce8\u7b2c14\u5929\u5373\u53ef\u8fbe\u5230\u8f83\u9ad8\u7684CR\u7387\uff0c\u4e14\u6bd2\u6027\u8f83\u4f4e\u3002\u4f46\u4ecd\u9700\u5bf9\u8fd9\u4e9b\u60a3\u8005\u8fdb\u884c\u957f\u671f\u89c2\u5bdf\uff0c\u5e76\u8fdb\u884c\u66f4\u5927\u8303\u56f4\u7684\u60a3\u8005\u7814\u7a76\u3002\u53e6\u5916\uff0c\u9274\u4e8eSTAR-T\u7684TCR-T\u57fa\u7840\u7ed3\u6784\uff0c\u5176\u6709\u671b\u5728\u5b9e\u4f53\u7624\u6cbb\u7597\u65b9\u5411\u53d6\u5f97\u91cd\u5927\u7a81\u7834\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><b>POSTER <\/b><b>\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u6280\u672f\u6210\u719f\u7597\u6548\u5353\u8457<\/b><\/p>\n<p><b>Poster1<\/b><\/p>\n<p>\u7b2c\u4e00\u4f5c\u8005\uff1a\u8d75\u8273\u4e3d\uff1b\u901a\u8baf\u4f5c\u8005\uff1a\u8d75\u8273\u4e3d&nbsp;\u6458\u8981\u53f7\uff1aEP1230<\/p>\n<p>Outcomes following unmanipulated haploidentical hematopoietic stem cell transplantation among 111 mixed-phenotype acute leukemia patients at a single center<\/p>\n<p>\u5355\u4e2d\u5fc3111\u540d\u6df7\u5408\u8868\u578b\u6025\u6027\u767d\u8840\u75c5\u8fdb\u884c\u5355\u500d\u4f53\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u7684\u7ed3\u679c<\/p>\n<p>\u6df7\u5408\u8868\u578b\u6025\u6027\u767d\u8840\u75c5(MPAL)\u53d1\u75c5\u7387\u4f4e\uff0c\u901a\u5e38\u4e0e\u4e0d\u826f\u9884\u540e\u76f8\u5173\u3002MPAL\u60a3\u8005\u7684\u6700\u4f73\u6cbb\u7597\u65b9\u6848\uff0c\u4ee5\u53ca\u5f02\u57fa\u56e0\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u7684\u5730\u4f4d\u5c1a\u4e0d\u6e05\u695a\u3002\u5927\u591a\u6570\u65e2\u5f80\u62a5\u9053\u53ea\u5305\u62ec\u5c11\u91cf\u7684\u79fb\u690d\u60a3\u8005\uff0c\u5176\u4e2d\u5355\u500d\u4f53\u79fb\u690d\u5f88\u5c11\u88ab\u5305\u62ec\u5728\u5185\u3002\u6211\u4eec\u8bd5\u56fe\u8bc4\u4f30\u5355\u500d\u4f53\u79fb\u690d\u6cbb\u7597MPAL\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u5e76\u8bd5\u56fe\u786e\u5b9a\u9ad8\u5371\u56e0\u7d20\u3002<\/p>\n<p>\u56de\u987e\u6027\u5206\u6790\u6839\u636e2017\u5e74\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\uff08WHO\uff09\u6807\u51c6\u5b9a\u4e49\u7684MPAL\u8bca\u65ad\u60a3\u8005\u7684\u4e34\u5e8a\u7ed3\u679c\u3002\u6240\u6709\u60a3\u8005\u4e8e2012\u5e747\u6708\u81f32020\u5e7412\u6708\u5728\u9646\u9053\u57f9\u533b\u9662\u63a5\u53d7\u79fb\u690d\u3002\u6700\u65b0\u7684\u968f\u8bbf\u65e5\u671f\u662f2020\u5e7412\u6708\u3002<\/p>\n<p>MPAL\u5360\u6240\u6709\u6025\u6027\u767d\u8840\u75c5\u60a3\u8005\u76843.1%\uff08131 \/ 4212\uff09\u3002\u6211\u4eec\u5206\u6790\u4e86111\u4f8bMPAL\u60a3\u8005\u5e94\u7528\u6297\u80f8\u817a\u7ec6\u80de\u7403\u86cb\u767d\uff08ATG\uff09\u7684\u5355\u500d\u4f53\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u7ed3\u679c\u3002\u4e2d\u4f4d\u5e74\u9f84\u4e3a15\u5c81\uff08\u8303\u56f4\uff1a1- 60\u5c81\uff09\u3002\u60a3\u8005\u6709\u4e09\u79cd\u514d\u75ab\u8868\u578b\u4e4b\u4e00\uff1a61\u4f8b\u4f34B\/\u9ad3\u7cfb\u6807\u8bb0\uff0c65\u4f8b\u4f34T\/\u9ad3\u7cfb\u6807\u8bb0\uff0c5\u4f8b\u4f34B\/T\/\u9ad3\u7cfb\u6807\u8bb0\u300215\u4f8bBCR-ABL1\u91cd\u6392\uff0c5\u4f8bKMT2a\u91cd\u6392\u3002\u79fb\u690d\u65f679\u4f8b\u60a3\u8005\u4e3a\u7b2c\u4e00\u6b21\u5b8c\u5168\u7f13\u89e3\uff08CR1\uff09\uff0c&nbsp;31\u4f8bCR2\u548c23\u4f8b\u672a\u7f13\u89e3\uff08NR\uff09\u3002\u6240\u6709\u60a3\u8005\u5747\u91c7\u7528\u6e05\u9ad3\u65b9\u6848\uff0c\u5176\u4e2dTBI\u9884\u5904\u7406\u65b9\u6848&nbsp;80\u4f8b\uff082Gy&times;5~6\uff09\uff0cBu\u9884\u5904\u7406&nbsp;41\u4f8b\uff083.2 mg\/kg\/day&times;4\uff09\u3002\u73af\u5b62\u7d20\u3001\u77ed\u671f\u7532\u6c28\u8776\u5464\u548c\u9709\u915a\u9178\u916f\u7528\u4e8e\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\uff08GVHD\uff09\u7684\u9884\u9632\u3002\u603b\u5355\u4e2a\u6838\u7ec6\u80de\uff08MNC\uff09\u548cCD34+\u7ec6\u80de\u4e2d\u4f4d\u6570\u5206\u522b\u4e3a9.0 &times;108\/kg\uff08\u8303\u56f4\uff1a3.94-19.13 &times;108\/kg\uff09\u548c4.72 &times;106\/kg\uff08\u8303\u56f4\uff1a1.27-12.57&times;106\/kg\uff09\u3002\u96642\u4f8b\u633d\u6551\u79fb\u690d\u60a3\u8005\uff08\u5747\u4e8e\u79fb\u690d\u540e\u7b2c2\u5929\u6b7b\u4e8e\u8113\u6bd2\u75c7\uff09\u5916\uff0c\u6240\u6709\u60a3\u8005\u5728\u79fb\u690d\u540e\u5e73\u574714\u5929\uff08\u8303\u56f4\uff1a9-34\u5929\uff09\u83b7\u5f97\u4e2d\u6027\u7c92\u7ec6\u80de\u690d\u5165\u3002104\u4f8b\u60a3\u8005\u5728\u79fb\u690d\u540e\u5e73\u574713\u5929\uff086-73\u5929\uff09\u83b7\u5f97\u8840\u5c0f\u677f\u690d\u5165\u3002\u622a\u81f3\u6700\u65b0\u968f\u8bbf\u65e5\u671f\uff0c\u4e2d\u4f4d\u751f\u5b58\u65f6\u95f4\u4e3a34\u4e2a\u6708\uff08\u8303\u56f4\uff1a1 &#8211; 93\u4e2a\u6708\uff09\u30023\u5e74\u590d\u53d1\u7387\u4e3a12.1%\uff0895% CI 5.4% ~ 18.8%\uff09\uff0c3\u5e74\u975e\u590d\u53d1\u6b7b\u4ea1\u7387\uff08NRM\uff09\u4e3a20.7%\uff0895% CI 12.7 ~ 28.7%\uff09\u30023\u5e74\u603b\u751f\u5b58\u7387\uff08OS\uff09\u548c3\u5e74\u65e0\u767d\u8840\u75c5\u751f\u5b58\u7387\uff08LFS\uff09\u5206\u522b\u4e3a69.5%\uff0895% CI 60.5-78.5%\uff09\u548c69.6%\uff0895% CI 60.8-78.4%\uff09\u3002CR1\u53ca\u2265CR2\u60a3\u8005\u548cNR\u60a3\u8005\u76843\u5e74LFS\u5206\u522b\u4e3a75.4%\uff0895% CI 64.2-86.6%\uff09\u300170.1%\uff0895% CI 52.7-87.5%\uff09\u548c52.5%\uff0895% CI 31.1-73.9%\uff09\u3002<span id=\"spanHghlt4a06\">\u2265<\/span>CR2 p = 0.416\uff1bCR1\u4e0eNR p=0.024\uff1bCR2 vs.NR p=0.213<span id=\"spanHghltc02a\">\uff09<\/span>\u3002\u4e0d\u540c\u514d\u75ab\u8868\u578b\u7ec4\uff08B\/\u9ad3\u7cfbvs. T\/\u9ad3\u7cfb\uff09\u60a3\u8005\u7684\u590d\u53d1\u7387\u3001NRM\u3001OS\u6216LFS\u5747\u65e0\u5dee\u5f02\uff0c\u5e74\u9f84\uff08&lt;13\u5c81vs.\u226514\u5c81\uff09\u3001\u9884\u5904\u7406\u65b9\u6848\uff08TBI vs. Bu\uff09\u6216\u79fb\u690d\u65e5\u671f\uff082012-2017\u5e74vs. 2018-2020\u5e74\uff09\u4e5f\u65e0\u5dee\u5f02\u3002\u5728\u591a\u53d8\u91cf\u5206\u6790\u4e2d\uff0c\u79fb\u690d\u524d\u72b6\u6001\u662f\u590d\u53d1\u7387\uff08\u5371\u9669\u6bd4[6]2.151;95% CI 1.058-4.375;p=0.034\uff09\u3001OS\uff08HR 1.598;95%CI 1.048-2.435;p=0.033\uff09\u548cLFS\uff08HR 1.574;95%CI 1.044-2.375;p=0.031\uff09\u7684\u552f\u4e00\u9884\u540e\u56e0\u7d20\u3002<\/p>\n<p>\u8d75\u8273\u4e3d\u4e3b\u4efb\uff1a\u5355\u500d\u4f53\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u662fMPAL\u60a3\u8005\u7684\u4e00\u79cd\u6709\u5e0c\u671b\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u5177\u6709\u4ee4\u4eba\u9f13\u821e\u7684\u4f4e\u590d\u53d1\u7387\u548c\u957f\u671f\u751f\u5b58\u7387\u3002\u65e9\u671f\u63a5\u53d7\u79fb\u690d\u7684\u60a3\u8005\u53ef\u80fd\u6709\u66f4\u597d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7ed3\u679c\u3002<\/p>\n<p><b>Poster2<\/b><\/p>\n<p>\u7b2c\u4e00\u4f5c\u8005\uff1a\u989c\u8ff0\uff1b\u901a\u8baf\u4f5c\u8005\uff1a\u5218\u5fb7\u7430&nbsp;\u6458\u8981\u53f7\uff1aEP1248<\/p>\n<p>Outcome of allogeneic hematopoietic stem cell transplantation for AML patients with 11P15\/NUP98 rearrangement<\/p>\n<p>\uff08\u5f02\u57fa\u56e0\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u6cbb\u7597\u4f3411p15\/NUP98\u57fa\u56e0\u91cd\u6392\u7684\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u75c5\u4f8b\u7597\u6548\u5206\u6790\uff09<\/p>\n<p>NUP98\u57fa\u56e0\u91cd\u6392\u7684AML\u60a3\u8005\u5355\u7528\u5316\u5b66\u6cbb\u7597\u6cbb\u7597\u7684\u603b\u4f53\u751f\u5b58\u7387\u53ca\u9884\u540e\u5dee\uff0c\u6587\u732e\u62a5\u90533\u5e74OS,LFS\u4f4e\u4e8e50%\uff0c\u90e8\u5206\u62a5\u9053\u4e2d\u4f4dOS\u5c0f\u4e8e1\u5e74\uff0c\u5c24\u5176\u5408\u5e76\u6709FLT3\u57fa\u56e0\u7a81\u53d8\u7684\u60a3\u8005\uff0c\u5316\u7597\u7f13\u89e3\u7387\u4e0d\u9ad8\uff0c\u4e0d\u8db34%\uff0c\u9884\u540e\u4e0d\u826f\u3002\u5f02\u57fa\u56e0\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u662f\u53ef\u80fd\u6839\u6cbb\u7684\u624b\u6bb5\u3002<\/p>\n<p>\u56de\u987e\u6027\u5206\u67902019\u5e747\u67081\u65e5\u81f32021\u5e742\u67081\u65e5\u671f\u95f4\u6211\u966234\u4f8b\u4f34\u6709NUP98\u57fa\u56e0\u91cd\u6392\u7684AML\u60a3\u8005\u884c\u5f02\u57fa\u56e0\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u7684\u751f\u5b58\u5206\u6790\u3002\u67096\u79cdNUP98\u57fa\u56e0\u7684\u4f19\u4f34\u57fa\u56e0\uff0c\u5176\u4e2dNSD1\u670923\u4f8b\uff0cHOXA9\u67095\u4f8b\uff0cKDM5A\u67094\u4f8b\uff0cLNP1\u67091\u4f8b\uff0cHOXD13\u67091\u4f8b\u3002\u5973\u6027\u60a3\u800510\u4f8b\uff0c\u7537\u602724\u4f8b\u3002\u60a3\u8005\u7684\u4e2d\u4f4d\u5e74\u9f84\u4e3a&nbsp;16\u5c81\uff081-61\uff09\uff0c31\u4f8b\u4e3a\u534a\u76f8\u540c\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\uff0c3\u4f8b\u4e3a\u5168\u76f8\u5408\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u3002\u9884\u5904\u7406\u65b9\u6848\u4e2d\u5e94\u7528BU\/Cy\u800531\u4f8b\uff0cTBI\/Cy\u80054\u4f8b\u3002GVHD\u9884\u9632\u65b9\u6848\u4e3aATG+CSA+MMF+\u77ed\u7597\u7a0bMTX\u3002\u8f93\u6ce8\u7684\u5e72\u7ec6\u80de\u4e2d\u5355\u4e2a\u6838\u7ec6\u80de\u6570\u4e3a (10.5&plusmn;3.2)&times;108\/Kg,CD34+\u7ec6\u80de\u6570\u4e3a (5.5&plusmn;2.3)&times;106\/kg\u300234\u4f8b\u60a3\u8005\u4e2d\u767d\u7ec6\u80de\u5747\u690d\u6d3b\u6210\u529f\uff0c\u4e2d\u6027\u7c92\u7ec6\u80de\u690d\u6d3b\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a14\u5929\uff0810-23\uff09\uff0c\u8840\u5c0f\u677f\u690d\u6d3b\u65f6\u95f4\u4e3a13\u5929\uff087-58\u5929\uff09\uff0c\u67092\u4f8b\u60a3\u8005\u8840\u5c0f\u677f\u672a\u690d\u6d3b\u3002<\/p>\n<p>\u672c\u7814\u7a76\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a9\u4e2a\u6708\uff083-30\uff09\uff0c\u5e73\u5747\u751f\u5b58\u65f6\u95f4\u662f24&plusmn;2\u6708\uff0895%CI=19-27\uff09\u3002\u6240\u6709\u75c5\u4f8b\u4e2d\u53d1\u751fII-IV&deg;aGVHD\u53d1\u751f\u7387\u4e3a26%\uff089\/34\uff09\uff0c\u6162\u6027GVHD\u53d1\u751f\u7387\u4e3a&nbsp; 20.5%\uff087\/34\uff09\u30022\u5e74\u7684\u603b\u751f\u5b58\u7387\u548c\u65e0\u75c5\u751f\u5b58\u7387\u5206\u522b\u4e3a75.9&plusmn;7.5%, 75.6&plusmn;7.6%\u3002\u5176\u4e2d\u4f34\u6709FLT3\u7a81\u53d8\u7ec4\uff08n=18\uff09\u7684\u4e0e\u4e0d\u4f34\u6709FLT3\u7ec4(n=16)\u7684\u603b\u751f\u5b58\u7387\u5206\u522b\u662f71.3&plusmn;10.9% VS 81.3&plusmn;9.8%\uff08P&gt;0.05\uff09\u3002\u79fb\u690d\u524dMRD \u9634\u6027\u7ec4\uff08n=13\uff09\u4e8eMRD \u9633\u6027\u7ec4\uff08n=21\uff09\u7684\u603b\u4f53\u751f\u5b58\u7387\u5206\u522b\u662f84.6.3&plusmn;10.0%VS 70.3&plusmn;10.3%\uff08P&gt;0.05\uff09\uff0c\u65e0\u7edf\u8ba1\u5b66\u5dee\u5f02\u3002100\u5929\u5185\u7684\u6b7b\u4ea1\u7387\u4e3a11.7%\uff084\/34\uff09\u30028\u4f8b\u60a3\u8005\u6b7b\u4ea1\uff0c\u5176\u4e2d\u67094\u4f8b\u56e0\u590d\u53d1\u6b7b\u4ea1\uff0c\u67093\u4f8b\u56e0IV&deg;GVHD\uff0c\u67091\u4f8b\u56e0TMA,\u67091\u4f8b\u786c\u8111\u819c\u4e0b\u51fa\u8840\u6b7b\u4ea1\u30025\u4f8b\u590d\u53d1\u60a3\u8005\u4e2d\uff0c1\u4f8b\u4e3a\u5206\u5b50\u751f\u7269\u5b66\u590d\u53d1\uff0c\u7ecf\u5316\u7597\u8054\u5408\u4f9b\u8005\u7ec6\u80de\u8f93\u6ce8\u540e\u57fa\u56e0\u8f6c\u4e3a\u9634\u6027\uff0c\u53e6\u59164\u4f8b\u590d\u53d1\u7684\u60a3\u8005\u5747\u6b7b\u4ea1\u3002<\/p>\n<p>\u8be5\u56de\u987e\u6027\u5206\u6790\u8bc1\u5b9e\u4e86\u5f02\u57fa\u56e0\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u6cbb\u7597\u4f34\u6709NUP98\u878d\u5408\u57fa\u56e0\u7684AML\u60a3\u8005\u7684\u7ed3\u679c\u4e0e\u65e2\u5f80\u5355\u72ec\u5316\u7597\u7684\u6570\u636e\u6bd4\u8f83\uff0c\u7ed3\u679c\u4ee4\u4eba\u9f13\u821e\uff0c\u7279\u522b\u662f\u540c\u65f6\u4f34\u6709FLT3\u57fa\u56e0\u7a81\u53d8\u7684\u60a3\u8005\u3002\u540c\u65f6\u9700\u8981\u5927\u89c4\u6a21\u7684\u4e34\u5e8a\u7814\u7a76\u6765\u8bc1\u5b9e\u8fd9\u4e00\u7ed3\u679c\u3002<\/p>\n<p><b>Poster3<\/b><\/p>\n<p>\u7b2c\u4e00\u4f5c\u8005\uff1a\u5468\u80dc\u7537\uff1b\u901a\u8baf\u4f5c\u8005\uff1a\u718a\u654f&nbsp;\u6458\u8981\u53f7\uff1aEP1249<\/p>\n<p>Effect of hematopoietic stem cell transplantation(HSCT) in severe congenital neutropenia<\/p>\n<p>\uff08\u5f02\u57fa\u56e0\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u6cbb\u7597\u5148\u5929\u6027\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u7684\u7597\u6548\u89c2\u5bdf\uff09<\/p>\n<p>\u5148\u5929\u6027\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u662f\u4e00\u79cd\u767d\u8840\u75c5\u524d\u671f\u9aa8\u9ad3\u8870\u7aed\u7efc\u5408\u5f81\u3002\u60a3\u8005\u4e0d\u4ec5\u957f\u671f\u9762\u4e34\u611f\u67d3\u53ca\u611f\u67d3\u52a0\u91cd\u7684\u98ce\u9669\uff0c\u4e5f\u5b58\u5728\u6f14\u53d8\u6210\u767d\u8840\u75c5\u6216\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\u7b49\u6076\u6027\u8840\u6db2\u75c5\u7684\u98ce\u9669\u3002\u6839\u636e\u56fd\u9645\u4e0a\u62a5\u9053\uff0c\u5f02\u57fa\u56e0\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u662f\u6cbb\u7597\u6b64\u75be\u75c5\u7684\u6709\u6548\u65b9\u6cd5\u3002\u6211\u4eec\u56e2\u961f\u884c\u5f02\u57fa\u56e0\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u6cbb\u7597\u5341\u51e0\u4f8b\u5148\u5929\u6027\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u3002\u4f9b\u8005\u7c7b\u578b\u6d89\u53ca\u8110\u5e26\u8840\u3001\u4eb2\u7f18\u5355\u500d\u4f53\u3001\u975e\u8840\u7f18\u3001\u540c\u80de\u5168\u76f8\u5408\u3002<\/p>\n<p>\u56de\u987e\u6027\u5206\u67902015\u5e744\u6708\u81f32020\u5e747\u6708\u671f\u95f4\uff0c\u6211\u966211\u4f8b\u5148\u5929\u6027\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u60a3\u8005\u884c\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u7684\u7597\u6548\u5206\u6790\u3002\u6240\u6709\u60a3\u8005\u5747\u4f34E-LANE \u57fa\u56e0\u7a81\u53d8\u3002\u4e2d\u4f4d\u5e74\u9f84\u4e3a3\u5c81\uff081~14\u5c81\uff09\u3002\u7537\u5973\u6bd4\u4f8b\u4e3a7:4\u3002\u4ece\u8bca\u65ad\u5230\u79fb\u690d\u7684\u4e2d\u4f4d\u75c5\u7a0b\u4e3a37\uff088~165\uff09\u4e2a\u6708\u30026\u4f8b\u60a3\u8005\u63a5\u53d7\u8110\u5e26\u8840\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\uff0c\u9884\u5904\u7406\u65b9\u6848\u4e3a\uff1a\u6c1f\u8fbe\u62c9\u6ee8(40mg\/m2\/dX5d)+\u963f\u7cd6\u80de\u82f7(2g\/m2\/dX5d)+Bu(0.8mg-1.2mg\/kg Q6hX4d)+\u73af\u78f7\u9170\u80fa(1.8g\/m2\/d)+ATG(\u5373\u590d\u5b811.25mg\/kg\/dX2d) \u30022\u4f8b\u60a3\u8005\u884c\u975e\u8840\u7f18\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\uff0c2\u4f8b\u884c\u4eb2\u7f18\u5355\u500d\u4f53HSCT\u6cbb\u7597\uff0c\u53e61\u4f8b\u4e3a\u540c\u80de\u5168\u76f8\u5408\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u3002\u9884\u5904\u7406\u65b9\u6848\u4e3a\uff1a\u6c1f\u8fbe\u62c9\u6ee8(40mg\/m2\/dX5d)+\u963f\u7cd6\u80de\u82f7(2g\/m2\/dX5d)+Bu(0.8mg-1.2mg\/kg Q6hX4d)+\u73af\u78f7\u9170\u80fa(1.8g\/m2\/d)+ATG(\u8d39\u68ee\u5c24\u65af4mg\/kg\/dX4d) \u3002\u4f7f\u7528&nbsp;CsA\/\u4ed6\u514b\u83ab\u53f8\u52a0\u77ed\u7a0bMTX\u9884\u9632\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\uff08GVHD\uff09\u3002<\/p>\n<p><b>\u7ed3\u679c\uff1a<\/b>11\u4f8b\u60a3\u8005\u5747\u53ef\u8010\u53d7\u9884\u5904\u7406\u5316\u7597\u3002\u4e2d\u6027\u7c92\u7ec6\u80de\u690d\u5165\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a11\u5929\uff089~16\u5929\uff09\uff1b\u8840\u5c0f\u677f\u690d\u5165\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a12\uff089~36\uff09\u5929\u3002\u603b\u690d\u5165\u7387\u4e3a100%\u3002\u4e2d\u4f4d\u968f\u8bbf25\u4e2a\u6708\uff083~70\u4e2a\u6708\uff09\u671f\u95f4\uff0cCMV\u53d1\u751f\u7387\u4e3a72.7%\uff1b\u6240\u6709\u60a3\u8005\u8840\u6d46\u4e2d\u5747\u672a\u68c0\u51faEB\u75c5\u6bd2\u30024\u4f8b\u60a3\u8005\u53d1\u751fII~IV\u7ea7aGVHD\uff0c\u536036.3%\u30022\u4f8b\u60a3\u8005\u53d1\u751fcGVHD\u3002\u5176\u4e2d2\u4f8b\u60a3\u8005\u6b7b\u4e8eGVHD\uff0c\u5176\u4f59\u60a3\u8005\u5747\u5b58\u6d3b\uff0c\u968f\u8bbf\u671f\u5185\u603b\u751f\u5b58\u7387\uff08OS\uff09\u4e3a81.81%\u3002<\/p>\n<p>\u6211\u4eec\u7684\u7edf\u8ba1\u7ed3\u679c\u8868\u660e\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u6cbb\u7597\u5148\u5929\u6027\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff0c\u5177\u6709\u8f83\u9ad8\u7684\u690d\u5165\u7387\u548c\u603b\u751f\u5b58\u7387\uff0c\u53ef\u80fd\u6210\u4e3a\u4e00\u79cd\u53ef\u884c\u7684\u6cbb\u7597\u9009\u62e9\u3002\u4f46\u56e0\u5b58\u5728\u79fb\u690d\u76f8\u5173\u5e76\u53d1\u75c7\uff0c\u79fb\u690d\u4f9b\u8005\u53ca\u6cbb\u7597\u65f6\u673a\u7684\u9009\u62e9\u975e\u5e38\u91cd\u8981\u3002<\/p>\n<p><b>POSTER <\/b><b>\u75c5\u7406\u4e0e\u68c0\u9a8c\u533b\u5b66\u79d1\u7814\u6210\u679c\u4e30\u7855\u4e1a\u5185\u4fe1\u8d56<\/b><\/p>\n<p><b>Poster4<\/b><\/p>\n<p>\u7b2c\u4e00\u4f5c\u8005\uff1a\u738b\u5f64\uff1b\u901a\u8baf\u4f5c\u8005\uff1a\u5218\u7ea2\u661f\uff0c\u6458\u8981\u53f7\uff1aEP339<\/p>\n<p>The laboratory examination characteristics and clinical outcomes of T(12;17)(P13;Q21)\/TAF15-ZNF384 positive acute leukemia<\/p>\n<p>TAF15-ZNF384\u9633\u6027\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u7684\u9057\u4f20\u5b66\u3001\u514d\u75ab\u5206\u578b\u7279\u5f81\u53ca\u7597\u6548\u89c2\u5bdf<\/p>\n<p>\u91c7\u96c62009.1.1-2020.12.30\u5c31\u8bca\u4e8e\u6cb3\u5317\u71d5\u8fbe\u9646\u9053\u57f9\u533b\u9662\u768415000\u4f59\u4f8bALL\u60a3\u8005\u9aa8\u9ad3\u6807\u672c\uff0c\u91c7\u7528\u5e38\u89c4\u7ec6\u80de\u9057\u4f20\u5b66G\u663e\u5e26\u6838\u578b\u5206\u6790\uff0c\u6d41\u5f0f\u7ec6\u80de\u672f\uff0c\u8367\u5149\u539f\u4f4d\u6742\u4ea4\uff08FISH\uff0cZNF384\u5206\u79bb\u63a2\u9488\uff09\uff0cRNA\u6d4b\u5e8f\uff08RNA seq\uff09\uff0cPCR\u6269\u589e\uff0c\u8840\u6db2\u80bf\u7624\u76f8\u5173\u57fa\u56e0\u7a81\u53d8\u7b5b\u67e5\u7b49\u65b9\u6cd5\uff0c\u68c0\u6d4bt(12; 17)(p13;q21)\u67d3\u8272\u4f53\u6613\u4f4d\u53caTAF15-ZNF384\u878d\u5408\u57fa\u56e0\uff0c\u5e76\u5bf9\u9633\u6027\u60a3\u8005\u8fdb\u4e00\u6b65\u5206\u6790\u9057\u4f20\u5b66\u3001\u514d\u75ab\u5206\u578b\u7279\u70b9\uff0c\u4e34\u5e8a\u6cbb\u7597\u548c\u8f6c\u5f52\u3002<\/p>\n<p><b>\u7ed3\u679c\uff1a<\/b>\u5171\u68c0\u51fa12\u4f8b\u9633\u6027\u60a3\u8005\uff0c\u75378\u4f8b\uff0c\u59734\u4f8b\uff0c\u5e74\u9f843-49\u5c81\uff0c\u4e2d\u4f4d\u5e74\u9f8425.5\u5c81\uff0c\u513f\u7ae53\u4f8b\uff0c\u6210\u4eba9\u4f8b\u3002\u53d1\u75c5\u65f6\u767d\u7ec6\u80de\u8ba1\u65701.58-38&times;10<sup>9<\/sup>\/L\uff088\u4f8b\u60a3\u8005\uff09\uff0c4\u4f8b\u60a3\u8005\u4f4e\uff08&lt;4&times;10<sup>9<\/sup>\/L\uff09\uff0c4\u4f8b\u60a3\u8005\u9ad8\uff08&gt;15&times;10<sup>9<\/sup>\/L\uff09\u3002\u514d\u75ab\u5206\u578b\u7ed3\u679c\u8868\u660e\u6240\u6709\u60a3\u8005\u5747\u8868\u8fbeCD19\u3001CD34\uff0cD13\u548c\/\u6216CD33\uff0c11\u4f8b\u4e3a\u6025\u6027B\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u4f34\u9ad3\u7cfb\u8868\u8fbe\uff0c1\u4f8b\u6df7\u5408\u7ec6\u80de\u767d\u8840\u75c5\uff08\u8868\u8fbeB\u7cfb\u3001\u9ad3\u7cfb\u6807\u5fd7\uff09\u30025\u4f8b\u60a3\u8005\u4e0d\u8868\u8fbeCD10\uff0c7\u4f8b\u60a3\u8005\u90e8\u5206\u8868\u8fbe\u6216\u8868\u8fbeCD10\uff0c10\u4f8b\u8868\u8fbeCD22\uff0c\u4e0d\u8868\u8fbeCD20\uff08\u4ec51\u4f8b\u5f31\u8868\u8fbe\uff09\u3002\u67d3\u8272\u4f53\u7ed3\u679c\u663e\u793a9\u4f8b\u60a3\u8005\u8d77\u75c5\u6216\u590d\u53d1\u65f6\u68c0\u51fat(12;17)\u67d3\u8272\u4f53\u6613\u4f4d\uff0c\u5176\u4e2d2\u4f8b\u4e3a\u5355\u7eaft(12;17)\u6613\u4f4d\uff0c7\u4f8b\u60a3\u8005\u4f34\u9644\u52a0\u67d3\u8272\u4f53\u5f02\u5e38\u30021\u4f8b\u67d3\u8272\u4f53\u6838\u578b\u6b63\u5e38\uff0c2\u4f8b\u672a\u51fa\u73b0t(12;17)\u6613\u4f4d\uff0c\u53ef\u80fd\u5b58\u5728\u9690\u533f\u6027\u6613\u4f4d\uff08\u4e00\u4e3a\u590d\u6742\u6838\u578b\uff0c\u4e00\u4f34\u5176\u4ed6\u9644\u52a0\u5f02\u5e38\uff09\uff0c\u7ecfRNAseq\u5747\u68c0\u6d4b\u51faTAF15-ZNF384\u878d\u5408\u57fa\u56e0\u9633\u6027\u3002FISH-ZNF384\u5206\u79bb\u63a2\u9488\u7ed3\u679c\u8868\u660e9\u4f8b\u60a3\u8005\u4e3a\u5178\u578b\u5206\u79bb\u4fe1\u53f7\uff0c1\u4f8b\u60a3\u8005\u4e22\u5931\u4e00\u4e2aZNF384\u57fa\u56e0\u4fe1\u53f7\uff0c1\u4f8b\u60a3\u8005\u4e22\u5931\u4e00\u4e2aZNF384\u57fa\u56e0\u90e8\u5206\u4fe1\u53f7\uff08\u590d\u6742\u6838\u578b\u8005\uff09\uff0c1\u4f8b\u60a3\u8005\u4e3a\u6b63\u5e38\u4fe1\u53f7\uff08\u6b63\u5e38\u6838\u578b\u8005\uff09\uff0c\u4f46\u8fd93\u4f8b\u60a3\u8005\u7ecfRNAseq\u6d4b\u5e8f\u5206\u6790\u5747\u5b58\u5728TAF15-ZNF384\u878d\u5408\u57fa\u56e0\uff0c\u4e14\u4e3aTAF15 exon6\u4e0eZNF384 exon3\u578b\u878d\u5408\uff0c\u8868\u660eRNAseq\u6280\u672f\u66f4\u80fd\u53d1\u73b0\u7ec6\u5fae\u7684\u57fa\u56e0\u5f02\u5e38\u300210\u4f8b\u60a3\u8005\u8840\u6db2\u80bf\u7624\u76f8\u5173\u57fa\u56e0\u7a81\u53d8\uff0886\u79cd\uff09\u5206\u6790\u53d1\u73b0ETV6\uff083\u4f8b\uff09\u3001FLT3-ITD\uff082\u4f8b\uff09\u3001CBL\uff082\u4f8b\uff09\u3001PTPN11\uff082\u4f8b\uff09\u3001TET2\uff082\u4f8b\uff09\u3001KMT2D\uff082\u4f8b\uff09\u4ee5\u53caNRAS\u3001KRAS\u3001KMT2D\u3001IKZF-IK6\u7b49\u57fa\u56e0\u7a81\u53d8\u5448\u9633\u6027\uff0cRNAseq\u6d4b\u5e8f\u663e\u793aTAF15- ZNF384\u878d\u5408\u57fa\u56e0\u67093\u79cd\u5f62\u5f0f\uff1aTAF15 exon6\u4e0eZNF384 exon3\uff0cTAF15 exon9\uff0cTAF15 exon11\u4e0eZNF384 exon3\u878d\u5408\uff0c\u540e\u8005\u8f83\u4e3a\u7f55\u89c1\uff0c\u6587\u732e\u4e2d\u4ec5\u89c11\u4f8b\u62a5\u9053\u3002\u660e\u786e\u8bca\u65ad\u540e\uff0c8\u4f8b\u60a3\u8005\u884c\u5e38\u89c4\u5316\u7597\uff0c\u8bf1\u5bfc\u53ca\u5de9\u56fa\u65b9\u6848\u4e3b\u8981\u5305\u62ecVDCLP \/CVDP\/ CAM \/ VDLP\/\u95e8\u51ac\u9170\u80fa\u9176\u3001\u6c28\u7532\u558b\u5464\u7b49\uff0c4\u4f8b\u60a3\u8005\u8fdb\u884c\u4e86\u5f02\u57fa\u56e0\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u3002\u6240\u6709\u60a3\u8005\u4e2d\uff0c1\u4f8b\u8bf1\u5bfc\u6cbb\u7597\u59cb\u7ec8\u4e0d\u7f13\u89e3\uff0c\u5176\u4f59\u60a3\u8005\u5bf9\u8bf1\u5bfc\u65b9\u6848\u53cd\u5e94\u826f\u597d\uff0c\u4f469\u4f8b\u60a3\u8005\u5728\u5de9\u56fa\u6cbb\u7597\u671f\u95f4\u590d\u53d1\uff0c\u5176\u4e2d5\u4f8b\u60a3\u8005\u5728\u8bca\u65ad\u540e8\u4e2a\u6708\u5185\u590d\u53d1\uff1b4\u4f8b\u79fb\u690d\u60a3\u8005\u4e2d\uff0c1\u4f8b\u5728\u8bca\u65ad94\u4e2a\u6708\uff0c\u4e8c\u6b21\u590d\u53d1\u65f6\u884c\u633d\u6551\u6027\u79fb\u690d\uff0c\u4e8e\u79fb\u690d\u540e+6\u4e2a\u6708\u6b7b\u4ea1\uff0c\u751f\u5b58\u65f6\u95f49\u5e74\u4f59\uff0c1\u4f8b\u4e8e\u633d\u6551\u6027\u79fb\u690d\u540e+3\u6708\u65f6\u590d\u53d1\uff0c\u4f592\u4f8b\u79fb\u690d\u540e\u83b7\u957f\u671f\u65e0\u4e8b\u4ef6\u751f\u5b58\uff0863m\u300113m\uff09\uff0c\u968f\u8bbf\u4e2d\u3002\u622a\u6b62\u81f3\u968f\u8bbf\u65e5\u671f\uff0c12\u4f8b\u60a3\u8005\u4e2d\u603b\u751f\u5b58\u6700\u957f102\u6708\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder4504\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/1549603\/1.html\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/1-476.jpg\" title=\"\" alt=\"\" \/><\/a><br \/><span><\/span><\/p>\n<\/p><\/div>\n<p><b>\u7ed3\u8bba\uff1a<\/b>\u4f34t (12;17)(p13;q21)\/TAF15-ZNF384\u878d\u5408\u57fa\u56e0\u9633\u6027ALL\u60a3\u8005\u6709\u72ec\u7279\u7684\u9057\u4f20\u5b66\u548c\u514d\u75ab\u8868\u578b\u7279\u5f81\uff0c\u67d3\u8272\u4f53\u6838\u578b\u591a\u6570\u4f34\u9644\u52a0\u5f02\u5e38\uff0c\u53caFLT3-PTPN11-CBLNRAS\/ KRAS\u901a\u8def\u57fa\u56e0\u7a81\u53d8\uff0cRNA-seq\u548cPCR\u53ef\u660e\u786e\u878d\u5408\u57fa\u56e0\u7684\u5b58\u5728\uff0c\u5c24\u5176\u5bf9\u590d\u6742\u6838\u578b\u548c\u9690\u533f\u6027\u5f02\u5e38\u3002\u514d\u75ab\u8868\u578b\u4e3a\u6076\u6027\u5e7c\u7a1aB\u6dcb\u5df4\u7ec6\u80de\u4f34\u9ad3\u7cfb\u8868\u8fbe\uff0c\u60a3\u8005\u5bf9\u5e38\u89c4\u8bf1\u5bfc\u5316\u7597\u53cd\u5e94\u826f\u597d\uff0c\u4f46\u6613\u590d\u53d1\uff0cCR1\u60a3\u8005\u6216\u8bb8\u53ef\u4ece\u5f02\u57fa\u56e0\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u83b7\u76ca\u3002<\/p>\n<p><b>Poster5<\/b><\/p>\n<p>\u7b2c\u4e00\u4f5c\u8005\uff1a\u738b\u5f64\uff1b\u901a\u8baf\u4f5c\u8005\uff1a\u5218\u7ea2\u661f\uff0c\u6458\u8981\u53f7\uff1aEP414<\/p>\n<p>The molecular basis and clinical outcomes of CALM-MLLT10 fusion positive acute leukemia<\/p>\n<p>CALM-AF10\u878d\u5408\u57fa\u56e0\u9a71\u52a8\u7684\u6025\u6027\u767d\u8840\u75c5\u5206\u5b50\u57fa\u7840\u548c\u4e34\u5e8a\u7ed3\u679c<\/p>\n<p>\u56de\u987e\u6027\u5206\u67902015\u5e741\u67081\u65e5\u81f32020\u5e7412\u670831\u65e5\u6211\u9662\u6536\u6cbb\u76849627\u4f8b\u6025\u6027\u767d\u8840\u75c5\u60a3\u8005\uff0c\u901a\u8fc7\u67d3\u8272\u4f53G\u663e\u5e26\u6838\u578b\u5206\u6790\u53caRT-PCR\u65b9\u6cd5\uff0c\u68c0\u51fa21\u4f8bCALM-AF10\u878d\u5408\u57fa\u56e0\u9633\u6027\u60a3\u8005\uff0c\u5bf9\u9633\u6027\u60a3\u8005\u8fdb\u4e00\u6b65\u5206\u6790\u4e8686\u79cd\u8840\u6db2\u80bf\u7624\u76f8\u5173\u57fa\u56e0\u7a81\u53d8\u53ca\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\u4ee5\u5206\u6790\u57fa\u56e0\u7ec4\u7279\u5f81\u3002<\/p>\n<p><b>\u7ed3\u679c\uff1a<\/b>21\u4f8b\u60a3\u8005\uff0c\u753716\u4f8b\uff0c\u59735\u4f8b\uff0c\u7537\u5973\u6bd4=3.2:1\uff0c\u6210\u4eba12\u4f8b\uff0c\u513f\u7ae59\u4f8b\uff0c\u4e2d\u4f4d\u5e74\u9f8424\uff084-37\uff09\u5c81\uff1bAML12\u4f8b\uff0cT-ALL 5\u4f8b\uff0cB-ALL 1\u4f8b\uff0c T\/B\u53caT\/\u9ad3\u6df7\u5408\u767d\u8840\u75c5\u54041\u4f8b\uff0cB\u6dcb\u5df4\u6bcd\u7ec6\u80de\u6dcb\u5df4\u76241\u4f8b\u3002AML\u4e2d\u67d3\u8272\u4f53\u6838\u578b91.6%\uff0811\/12\u4f8b\uff09\u4e3a\u590d\u6742\u5f02\u5e38\u6216\u4f34\u9644\u52a0\u5f02\u5e38\uff0c\u8840\u6db2\u80bf\u7624\u57fa\u56e0\u7ec4\u7a81\u53d8\u5206\u6790\u53d1\u73b0\uff0c\u4f34CALM-AF10 AML\u60a3\u8005PHF6\u57fa\u56e0\u7a81\u53d8\u9ad8\u9891\u53d1\u751f\uff0c\u4f34\u968f\u7a81\u53d8\u7387\u4e3a87.5%\uff087\/8\u4f8b\uff09\uff0c\u800c\u5bf9\u7167\u7ec4\uff08\u4e0d\u4f34CALM-AF10 AML\u60a3\u8005\uff09PHF6\u57fa\u56e0\u7a81\u53d8\u7387\u4ec5\u4e3a3%\uff0c\u6b64\u5916TET2, EZH2,TP53\u7b49\u57fa\u56e0\u7a81\u53d8\u4ea6\u9891\u7e41\u53d1\u751f\u3002T-ALL\u60a3\u8005PHF6\u57fa\u56e0\u4f34\u968f\u7a81\u53d8\u7387\u4e3a40%\uff0cJAK1\/3\u7a81\u53d8\u4f34\u968f\u7a81\u53d8\u7387\u4e3a80%\u3002\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\u5206\u6790\u663e\u793aHOXA\u5bb6\u65cf\u57fa\u56e0\u9ad8\u8868\u8fbe\uff0cMYCN\u3001MEIS1\u3001SOX4\u3001\u4ee5\u53caFLT3\uff08\u8840\u6db2\u80bf\u7624\u4e2d\u4e0e\u9884\u540e\u5dee\u5bc6\u5207\u76f8\u5173\uff09\u4e5f\u663e\u8457\u9ad8\u8868\u8fbe\u3002\u6cbb\u7597\u4e0e\u8f6c\u5f52\uff1a21\u4f8b\u60a3\u8005\u5e38\u89c4\u8bf1\u5bfc\u5316\u7597\u7597\u6548\u4e0d\u4f73\uff0c13\u4f8b\u60a3\u8005\u8fdb\u884c\u4e86\u5f02\u57fa\u56e0\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\uff0c5\u4f8b\u5b58\u6d3b\uff0c\u4e2d\u4f4d\u5b58\u6d3b\u65f6\u95f442\u6708\uff0c\u5176\u4e2d2\u4f8b\u56e0\u75be\u75c5\u590d\u53d1\u5206\u522b\u8fdb\u884c\u4e86\u4e8c\u6b21\u79fb\u690d\u548c\u4e09\u6b21\u79fb\u690d\uff1b8\u4f8b\u6b7b\u4ea1\uff0c\u6b7b\u56e0\u5206\u522b\u4e3a\u79fb\u690d\u540e\u590d\u53d1\uff085\u4f8b\uff09\u3001GVHD\uff081\u4f8b\uff09\u3001\u611f\u67d3\uff082\u4f8b\uff09\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder2253\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/1549621\/2.html\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/2-413.jpg\" title=\"\" alt=\"\" \/><\/a><br \/><span><\/span><\/p>\n<\/p><\/div>\n<p><b>\u7ed3\u8bba\uff1a<\/b>CALM-AF10\u878d\u5408\u57fa\u56e0\u603b\u53d1\u751f\u7387\u7ea60.2%\uff0c\u7537\u6027\u4e3a\u4e3b\uff0c\u53ef\u5411AML\u3001T-ALL\u3001B-ALL\u3001MPAL\u5404\u7cfb\u522b\u8f6c\u5316\uff0c\u8868\u660e\u878d\u5408\u57fa\u56e0\u5f62\u6210\u53d1\u751f\u5728\u8f83\u65e9\u671f\u5e72\u3001\u7956\u7ec6\u80de\u3002PHF6\u3001JAK1\/3\u53ca\u5176\u4ed6\u57fa\u56e0\u7a81\u53d8\u53ef\u7efc\u5408\u5224\u65ad\u767d\u8840\u75c5\u7cfb\u522b\u3002\u65e9\u671f\u8840\u7ec6\u80de\u5206\u5316\u9636\u6bb5\u3001\u590d\u6742\u53ca\u9644\u52a0\u5f02\u5e38\u6838\u578b\u3001\u5e7f\u6cdb\u7684HOXA\u5bb6\u65cf\u57fa\u56e0\u8fc7\u8868\u8fbe\uff0c\u540c\u65f6\u4f34\u968fPHF6\u3001JAK1\/3\u57fa\u56e0\u7a81\u53d8\u9ad8\u53d1\u7b49\uff0c\u53ef\u80fd\u5bfc\u81f4\u5e38\u89c4\u8bf1\u5bfc\u5316\u7597\u96be\u4ee5\u8fbe\u5230\u8840\u6db2\u5b66\u7f13\u89e3\uff0c\u751a\u81f3\u5f02\u57fa\u56e0\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u7597\u6548\u4e0d\u4f73\uff0c\u4e9f\u9700\u5bfb\u627e\u9776\u5411\u6cbb\u7597\u7684\u5206\u5b50\u9776\u70b9\uff0c\u4ee5\u53ca\u9776\u5411\u6cbb\u7597\u836f\u7269\uff0c\u4ee5\u6539\u5584\u7597\u6548\u3002 <\/p>\n<p><b>Poster6<\/b><\/p>\n<p>\u7b2c\u4e00\u4f5c\u8005\uff1a\u738b\u4e1c\u51fa\uff1b\u901a\u8baf\u4f5c\u8005\uff1a\u738b\u5349\uff1b\u6458\u8981\u53f7\uff1aEP742<\/p>\n<p>Differences in serum cytokine levels and peak times between CD19 and CD7 CAR-T treatment<\/p>\n<p>CD19\u548cCD7 CAR-T\u6cbb\u7597\u8840\u6e05\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\u548c\u5cf0\u503c\u5dee\u5f02\u5206\u6790<\/p>\n<p>\u6536\u96c686\u4f8bCD19 CAR-T\u6cbb\u7597\u60a3\u8005\u548c10\u4f8bCD7 CAR-T\u6cbb\u7597\u60a3\u8005\u5916\u5468\u8840\u6837\u672c\uff0c\u6839\u636eCRS\u4e25\u91cd\u7a0b\u5ea6\u5206\u7ea7\u5404\u5206\u4e3a\u4e24\u7ec4\uff1a79\/86\u4e3aCD19 CRS\u4f4e\u5206\u7ea7\u7ec4\uff080-1\u7ea7\uff09\uff0c7\/86\u4e3aCD19 CRS\u9ad8\u5206\u7ea7\u7ec4\uff082\u7ea7\u4ee5\u4e0a\uff09\uff0c7\/10\u4e3aCD7 CRS\u4f4e\u5206\u7ea7\u7ec4\uff0c3\/10\u4e3aCD7 CRS\u9ad8\u5206\u7ea7\u7ec4\u3002\u5728CAR-T\u8f93\u6ce8\u540e\u7684\u7b2c0\u30014\u30017\u300111\u300115\u300120\u300130\u5929\uff0c\u7528QBplex\u5fae\u7403\u8bd5\u5242\u76d2\u548c\u6d41\u5f0f\u7ec6\u80de\u4eea\u5bf9\u6837\u54c1\u8fdb\u884c24\u79cd\u7ec6\u80de\u56e0\u5b50\u7684\u68c0\u6d4b\u4e0e\u5206\u6790\u3002<\/p>\n<p><b>\u7ed3\u679c\uff1a<\/b>\u9996\u5148\uff0c\u5728CRS\u4f4e\u5206\u7ea7\u7ec4\u4e2d\uff0cCD7 \u7ec4\u5916\u5468\u8840\u4e2d20\u79cd\u7ec6\u80de\u56e0\u5b50\u660e\u663e\u9ad8\u4e8eCD19\u7ec4\uff08p&lt;0.05\uff09\u3002\u5176\u6b21\uff0c\u5728CRS\u9ad8\u5206\u7ea7\u7ec4\u4e2d\uff0cCD7\u7ec4\u4e0eCD19\u7ec4\u5747\u51fa\u73b0\u5cf0\u503c\uff0c\u4f46CD19\u7ec4\u4e2d\u5cf0\u503c\u65f6\u95f4\u65e9\u4e8eCD7\u7ec4\uff0cCD19\u7ec4\u5728\u7b2c7\u5929\u81f3\u7b2c10\u5929\u8fbe\u5230\u5cf0\u503c\uff0cCD7\u7ec4\u5728\u7b2c11\u5929\u81f3\u7b2c15\u5929\u8fbe\u5230\u5cf0\u503c\uff0c\u6709\u7684\u56e0\u5b50\u751a\u81f3\u5728\u7b2c20\u5929\u8fbe\u5230\u5cf0\u503c\u3002<\/p>\n<p><b>\u7ed3\u8bba\uff1a<\/b>\u901a\u8fc7\u6211\u4eec\u7684\u7814\u7a76\u53d1\u73b0\uff0cCRS\u4f4e\u5206\u7ea7\u7ec4\u4e2d\uff0cCD7\u7ec4\u660e\u663e\u51fa\u73b0\u4e86\u9ad8\u4e8eCD19\u7ec4\u7684\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\uff0c\u5373\u4f7f\u5206\u7ea7\u8f83\u4f4e\uff0cCD7\u7ec4\u90e8\u5206\u60a3\u8005\u4f9d\u7136\u51fa\u73b0\u4e86\u4e0e\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\u76f8\u4e00\u81f4\u7684\u5f3a\u70c8\u4e34\u5e8a\u75c7\u72b6\u8868\u73b0\uff0c\u800cCD19\u7ec4\u5374\u6ca1\u6709\u51fa\u73b0\u4e34\u5e8a\u75c7\u72b6\u6216\u8005\u4ec5\u6709\u8f7b\u5fae\u75c7\u72b6\u8868\u73b0\uff1b\u4e0e\u6b64\u540c\u65f6\uff0c\u5728CRS\u9ad8\u5206\u7ea7\u7ec4\u4e2d\uff0cCD7\u7ec4\u7ec6\u80de\u56e0\u5b50\u5cf0\u503c\u7684\u51fa\u73b0\u65f6\u95f4\u5927\u591a\u8981\u665a\u4e8eCD19\u7ec4\uff0c\u800c\u4e14CD7\u7ec4\u8f93\u6ce8\u540e\u7684\u526f\u4f5c\u7528\u51fa\u73b0\u65f6\u95f4\u4e5f\u665a\u4e8eCD19\u7ec4\u3002\u603b\u800c\u8a00\u4e4b\uff0c\u901a\u8fc7\u57fa\u4e8e\u5fae\u7403\u7684\u6d41\u5f0f\u7ec6\u80de\u68c0\u6d4b\u6280\u672f\u53ef\u4ee5\u6709\u6548\u7684\u68c0\u6d4b\u8840\u6e05\u4e2d\u7ec6\u80de\u56e0\u5b50\u7684\u6c34\u5e73\uff0c\u5bf9\u6bd4\u4e0d\u540c\u9776\u70b9CAR-T\u7ec6\u80de\u7597\u6cd5\u7684\u5dee\u5f02\uff0c\u5728\u672a\u6765CAR-T\u7ec6\u80de\u6cbb\u7597\u548c\u7814\u7a76\u4e2d\u5fc5\u5c06\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n<p><b>Poster7<\/b><\/p>\n<p>\u7b2c\u4e00\u4f5c\u8005\uff0c\u5bab\u7f8e\u7ef4\uff1b\u901a\u8baf\u4f5c\u8005\uff0c\u738b\u5349\uff1b\u6458\u8981\u53f7\uff1aEP1266<\/p>\n<p>Down-regulation of HLA expression in acute leukemia patients relapsed post-transplantation correlated with MRD duration<\/p>\n<p>\u6025\u6027\u767d\u8840\u75c5\u79fb\u690d\u540e\u590d\u53d1\u65f6\u80bf\u7624\u7ec6\u80deHLA\u8868\u8fbe\u6539\u53d8\u53caHLA\u8868\u8fbe\u4e0b\u8c03\u4e0eMRD\u7684\u76f8\u5173\u6027\u5206\u6790<\/p>\n<p>\u5f02\u57fa\u56e0\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u662f\u6cbb\u7597\u591a\u79cd\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u548c\u975e\u8840\u6db2\u7cfb\u7edf\u75be\u75c5\u7684\u91cd\u8981\u65b9\u6cd5\uff0c\u968f\u7740\u9884\u5904\u7406\u65b9\u6848\u3001GVHD\u9884\u9632\u548c\u652f\u6301\u6027\u62a4\u7406\u7684\u6539\u8fdb\uff0c\u79fb\u690d\u76f8\u5173\u6b7b\u4ea1\u7387\u5f97\u5230\u6709\u6548\u964d\u4f4e\uff0c\u4f46\u8840\u6db2\u80bf\u7624\u590d\u53d1\u4f9d\u7136\u662f\u79fb\u690d\u540e\u6b7b\u4ea1\u7684\u9996\u8981\u539f\u56e0\uff0c\u590d\u53d1\u7684\u514d\u75ab\u5b66\u539f\u7406\u4e0d\u540c\uff0c\u4e34\u5e8a\u5bf9\u75c7\u9009\u62e9\u6cbb\u7597\u7684\u836f\u7269\u4e5f\u4e0d\u540c\uff0c\u56e0\u6b64\u91c7\u7528\u5408\u9002\u7684\u68c0\u6d4b\u624b\u6bb5\u5398\u6e05\u590d\u53d1\u7684\u514d\u75ab\u5b66\u539f\u7406\uff0c\u53ef\u80fd\u4e3a\u9009\u62e9\u5408\u9002\u6cbb\u7597\u65b9\u5f0f\u63d0\u4f9b\u7ebf\u7d22\u3002<\/p>\n<p>2015\u5e74\u81f32020\u5e74\u6cb3\u5317\u71d5\u8fbe\u9646\u9053\u57f9\u533b\u9662\u5f02\u57fa\u56e0\u79fb\u690d\u60a3\u80052581\u4f8b\uff0c\u9009\u62e9\u5176\u4e2d32\u4f8b\u79fb\u690d\u540e\u590d\u53d1\u7684\u6025\u6027\u767d\u8840\u75c5\u60a3\u8005\u8fdb\u884c\u4e86HLA\u6297\u539f\u8868\u8fbe\u5206\u6790\uff0c\u7537\uff1a\u5973=23:9\uff0c\u5e74\u9f84\u4e2d\u4f4d17\u5c81\uff082-51\u5c81\uff09\u3002AML 18\u4f8b\uff0c&nbsp;B-ALL 7\u4f8b\uff0cT-ALL 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2021\u5e746\u67089-17\u65e5\uff0c\u7b2c26\u5c4a\u6b27\u6d32\u8840\u6db2\u5b66\u534f\u4f1a\uff08EHA\uff09\u5e74\u4f1a\u5c06\u5728\u7ebf\u4e0a\u5982\u671f\u53ec\u5f00\uff0c\u4f5c\u4e3a\u6b27\u6d32\u8840\u6db2\u5b66\u9886\u57df\u89c4\u6a21\u6700\u5927\u7684\u56fd\u9645\u6027\u4f1a\u8bae\uff0c\u6bcf\u5e74\u5438\u5f15\u6765\u81ea\u5168\u7403100\u591a\u4e2a\u56fd\u5bb6\u76841\u4e07\u591a\u540d\u4e13\u4e1a\u4eba\u58eb\u4e0e\u4f1a\uff0c\u5206\u4eab\u5168\u7403\u6700\u524d\u6cbf\u7684\u7814\u7a76\u8fdb\u5c55\u548c\u7a81\u7834\u6027\u4e34\u5e8a\u6570\u636e\u3002 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&nbsp; POSTER \u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u6280\u672f\u6210\u719f\u7597\u6548\u5353\u8457 Poster1 \u7b2c\u4e00\u4f5c\u8005\uff1a\u8d75\u8273\u4e3d\uff1b\u901a\u8baf\u4f5c\u8005\uff1a\u8d75\u8273\u4e3d&nbsp;\u6458\u8981\u53f7\uff1aEP1230 Outcomes following unmanipulated haploidentical hematopoietic stem&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2021062314430035047\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":35052,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-35047","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/35047","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=35047"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/35047\/revisions"}],"predecessor-version":[{"id":35051,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/35047\/revisions\/35051"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/35052"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=35047"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=35047"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=35047"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}