{"id":34971,"date":"2021-06-23T06:01:00","date_gmt":"2021-06-22T23:01:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021062306010034971"},"modified":"2021-06-23T21:37:11","modified_gmt":"2021-06-23T13:37:11","slug":"opaganib2%e6%9c%9f%e7%a0%94%e7%a9%b6%e7%a7%af%e6%9e%81%e6%95%b0%e6%8d%ae%e5%8f%91%e5%b8%83","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021062306010034971","title":{"rendered":"Opaganib2\u671f\u7814\u7a76\u79ef\u6781\u6570\u636e\u53d1\u5e03"},"content":{"rendered":"<table border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/RedHill_Biopharma_Logo.jpg\" border=\"0\" alt=\"\" title=\"logo\" hspace=\"0\" vspace=\"0\" width=\"118\" \/><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><p><i>Opaganib<\/i><i>\u662f\u4e00\u79cd<\/i><i>\u9886\u5148\u7684\u3001\u7528\u4e8e\u6cbb\u7597\u4e2d\u91cd\u5ea6\u65b0\u51a0\u80ba\u708e\u7684\u65b0\u578b\u53e3\u670d\u53cc\u673a\u5236\u5019\u9009\u836f\u7269\uff0c\u8be5\u836f\u7684\u7f8e\u56fd<\/i><i>2<\/i><i>\u671f\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7814\u7a76<\/i><i>\u79ef\u6781\u6570\u636e\u5df2\u5728\u4e16\u754c\u5fae\u751f\u7269\u8bba\u575b\uff08<\/i><i>World Microbe Forum<\/i><i>\uff09\u4e0a<\/i><i>\u53d1\u5e03<\/i>&nbsp;<\/p>\n<p><i>Opaganib<\/i><i>\u53ef\u51cf\u5c11\u60a3\u8005\u7684\u4f9b\u6c27\u9700\u6c42\u3001<\/i><i>\u7f29\u77ed\u4f4f\u9662\u65f6\u95f4\u5e76\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027<\/i>&nbsp;<\/p>\n<p><i>\u8fd9\u9879\u5171<\/i><i>474<\/i><i>\u540d\u60a3\u8005\u53c2\u4e0e\u7684<\/i><i>Opaganib<\/i><i>\u5168\u7403<\/i><i>2\/3<\/i><i>\u671f\u7814\u7a76\u5df2\u5b8c\u6210\u62db\u52df\uff0c<\/i><i>\u9884\u8ba1\u672a\u6765\u51e0\u5468\u5185\u5b8c\u6210\u7814\u7a76\u5de5\u4f5c<\/i>&nbsp;<\/p>\n<p><i>Opaganib<\/i><i>\u4ee5\u5bbf\u4e3b<\/i><i>\u4e3a\u9776\u6807\uff0c\u6709\u671b\u6709\u6548\u5bf9\u6297\u65b0\u51fa\u73b0\u7684\u75c5\u6bd2\u53d8\u79cd<\/i>&nbsp;<\/p>\n<p>\u4ee5\u8272\u5217\u7279\u62c9\u7ef4\u592b\u548c\u7f8e\u56fd\u5317\u5361\u7f57\u83b1\u7eb3\u5dde\u7f57\u52292021\u5e746\u670823\u65e5 \/\u7f8e\u901a\u793e\/ &#8212;&nbsp;\u7279\u79cd\u751f\u7269\u5236\u836f\u516c\u53f8<a target=\"_blank\" href=\"https:\/\/www.redhillbio.com\/RedHill\/\" rel=\"nofollow noopener\">RedHill Biopharma Ltd.<\/a>\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aRDHL\uff09\uff08\u4ee5\u4e0b\u7b80\u79f0\u201cRedHill\u201d\u6216\u201c\u516c\u53f8\u201d\uff09\u4eca\u5929\u5ba3\u5e03\uff0c\u57282021\u5e74\u4e16\u754c\u5fae\u751f\u7269\u8bba\u575b\uff08WWF\uff09\u4e0a\u53d1\u5e03\u53e3\u670dopaganib\uff08Yeliva&reg;\uff0cABC294640\uff09\u76842\u671f\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u79ef\u6781\u6570\u636e[1]\uff08\u6d77\u62a5\u7f16\u53f7\uff1a5574\uff09\u3002<\/p>\n<p>\u6d77\u62a5\u4ecb\u7ecd\u4e86\u7f8e\u56fd40\u540d\u60a3\u8005\u76842\u671f\u7814\u7a76\u7ed3\u679c\u548c\u540e\u7eed\u6570\u636e\u5206\u6790\uff0c\u5176\u6807\u9898\u4e3a<i>\u300a<\/i><i>Opaganib, an Oral Sphingosine Kinase-2 (SK2) Inhibitor in COVID-19 Pneumonia: A Randomized, Double-blind, Placebo-controlled Phase 2A Study, in Adult Subjects Hospitalized with SARS-CoV-2 Positive Pneumonia<\/i><i>\uff08<\/i><i><a target=\"_blank\" href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04414618\" rel=\"nofollow noopener\">NCT\uff1a04414618<\/a><\/i><i>\uff09\u300b<\/i>[2]\uff08Opaganib\uff0c\u65b0\u51a0\u80ba\u708e\u53e3\u670d\u9798\u6c28\u9187\u6fc0\u9176-2\uff08SK2\uff09\u6291\u5236\u5242\uff1a\u9488\u5bf9SARS-CoV-2\u9633\u6027\u6210\u4eba\u4f4f\u9662\u53d7\u8bd5\u8005\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u71672A\u671f\u7814\u7a76\uff08NCT\uff1a04414618\uff09\uff09\u3002\u5728\u63a5\u53d7\u6807\u51c6\u62a4\u7406\uff08SoC\uff09\uff08\u4e3b\u8981\u662f\u670d\u7528\u5730\u585e\u7c73\u677e\u548c\/\u6216\u745e\u5fb7\u897f\u97e6\uff09\u7684\u540c\u65f6\uff0c\u53c2\u4e0e\u7814\u7a76\u7684\u60a3\u8005\u968f\u673a\u670d\u7528opaganib\u6216\u5b89\u6170\u5242\u3002\u7814\u7a76\u7ed3\u679c\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u5230\u7b2c14\u5929\uff0c50%\u63a5\u53d7opaganib\uff08n=22\uff09\u6cbb\u7597\u7684\u60a3\u8005\u65e0\u9700\u4f9b\u6c27\uff0c\u800c\u5b89\u6170\u5242\u7ec4\uff08n=18\uff09\u7684\u8fd9\u4e00\u6bd4\u4f8b\u4e3a22%\u3002\u65e0\u8bba\u60a3\u8005\u662f\u5426\u5728\u63a5\u53d7\u5730\u585e\u7c73\u677e\u548c\/\u6216\u745e\u5fb7\u897f\u97e6\u6cbb\u7597\uff0c\u670d\u7528opaganib\u7684\u60a3\u8005\u90fd\u80fd\u5728\u7b2c14\u5929\u5b9e\u73b0\u65e0\u9700\u4f9b\u6c27\u3002 <\/li>\n<li>\u5230\u7b2c14\u5929\uff0c\u63a5\u53d7opaganib\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u670986.4%\u53ef\u4ee5\u51fa\u9662\uff0c\u800c\u63a5\u53d7\u5b89\u6170\u5242\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u8fd9\u4e00\u6bd4\u4f8b\u4e3a55.6% <\/li>\n<li>\u63a5\u53d7opaganib\u6cbb\u7597\u7684\u60a3\u8005\u7ec4\u7684\u51fa\u9662\u4e2d\u4f4d\u65f6\u95f4\u4e3a6\u5929\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u7684\u8fd9\u4e00\u65f6\u95f4\u4e3a7.5\u5929 <\/li>\n<li>81.8%\u7684\u63a5\u53d7opaganib\u6cbb\u7597\u7684\u60a3\u8005\u5728\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u7684\u987a\u5e8f\u91cf\u8868\u4e2d\u5b9e\u73b0\u4e862\u4e2a\u70b9\u7684\u6539\u5584\uff0c\u800c\u63a5\u53d7\u5b89\u6170\u5242\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u7684\u8fd9\u4e00\u6bd4\u4f8b\u4e3a55.6%\uff0c\u4e14\u4e24\u7ec4\u8fbe\u5230\u8fd9\u4e00\u76ee\u6807\u7684\u4e2d\u4f4d\u65f6\u95f4\u5206\u522b\u4e3a6\u5929\u548c7.5\u5929 <\/li>\n<li>\u4e24\u4e2a\u7ec4\u522b\u5728\u4e0e\u5b89\u5168\u6709\u5173\u7684\u63aa\u65bd\u65b9\u9762\u6ca1\u6709\u51fa\u73b0\u91cd\u5927\u5dee\u5f02\uff08\u8179\u6cfb\u662f\u5728\u8010\u836f\u6027\u65b9\u9762\u8868\u73b0\u51fa\u6765\u7684\u4e3b\u8981\u4e0d\u826f\u53cd\u5e94\uff09<\/li>\n<\/ul>\n<p>\u201c\u5f88\u660e\u663e\uff0c\u6211\u4eec\u9700\u8981\u6709\u6548\u7684\u53e3\u670d\u7597\u6cd5\u6765\u6cbb\u7597\u65b0\u51a0\u80ba\u708e\u3002\u8fd9\u79cd\u7597\u6cd5\u5c06\u5927\u5927\u63d0\u9ad8\u6211\u4eec\u63a7\u5236\u8fd9\u4e00\u6d41\u884c\u75c5\u7684\u80fd\u529b\uff0c\u201d<b>\u4fc4\u52d2<\/b><b>\u5188\u5065\u5eb7\u4e0e\u79d1\u5b66\u5927\u5b66\u4f20\u67d3\u75c5\u4e13\u4e1a\u6559\u6388\u3001\u533b\u5b66\u535a\u58eb\u3001\u516c\u5171\u536b\u751f\u7855\u58eb<\/b><b><span class=\"xn-person\">Kevin Winthrop<\/span><\/b><b>\u5728<\/b><b>WWF<\/b><b>\u4e0a\u4ecb<\/b><b>\u7ecd\u8fd9\u9879\u7814\u7a76\u7ed3\u679c\u65f6\u8868\u793a\u3002<\/b>\u201c\u901a\u8fc7\u8fd9\u9879\u5bf9\u91cd\u75c7\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u670d\u7528opaganib\u7684\u6982\u5ff5\u8bc1\u660e\u4e34\u5e8a\u7814\u7a76\uff0c\u8fd9\u4e9b\u6570\u636e\u8868\u660eSK2\u7684\u6291\u5236\u6548\u7528\u5728\u5bf9\u6297\u8fd9\u79cd\u75c5\u6bd2\u7684\u7597\u6548\u65b9\u9762\u5177\u6709\u6f5c\u5728\u4f5c\u7528\u3002\u9884\u8ba1\u672a\u6765\u51e0\u5468\u5c06\u6709\u66f4\u591a\u6709\u5173opaganib\u7684\u6570\u636e\uff0c\u6211\u4eec\u6709\u671b\u5728\u4e3a\u76ee\u524d\u7f3a\u4e4f\u53ef\u7528\u9009\u62e9\u7684\u60a3\u8005\u63d0\u4f9b\u6025\u9700\u7684\u53e3\u670d\u7597\u6cd5\u65b9\u9762\u53d6\u5f97\u4e00\u4e9b\u771f\u6b63\u8fdb\u5c55\u3002&quot;<\/p>\n<p>\u201c\u6211\u4eec\u4ece\u63a2\u7d22\u6027\u76842\u671f\u7814\u7a76\u4e2d\u83b7\u5f97\u7684\u8fd9\u4e9b\u79ef\u6781\u6570\u636e\u8ba9\u6211\u4eec\u4fe1\u5fc3\u8d8a\u6765\u8d8a\u8db3\uff0c\u76f8\u4fe1opaganib\u53ef\u4ee5\u6210\u4e3a\u7b2c\u4e00\u79cd\u5728\u4e00\u9879\u5927\u7684\u540e\u671f\u7814\u7a76\u4e2d\u663e\u793a\u51fa\u6709\u65b0\u51a0\u80ba\u708e\u7597\u6548\u7684\u65b0\u578b\u53e3\u670d\u7597\u6cd5\u3002\u968f\u7740\u6211\u4eec\u8fd1\u671f\u5b8c\u6210\u6709475\u540d\u60a3\u8005\u53c2\u52a0\u7684\u5168\u74032\/3\u671f\u7814\u7a76\u7684\u62db\u52df\u5de5\u4f5c\uff0c\u6211\u4eec\u5c06\u5728\u4e0d\u4e45\u7684\u5c06\u6765\u5bf9\u6b64\u6709\u66f4\u6e05\u6670\u7684\u4e86\u89e3\uff0c\u201d<b>RedHill<\/b><b>\u533b\u5b66<\/b><b>\u603b\u76d1\u3001\u533b\u5b66\u535a\u58eb\u3001\u54f2\u5b66\u535a\u58eb<\/b><b><span class=\"xn-person\">Mark L. Levitt<\/span><\/b><b>\u8bf4\u9053\u3002<\/b>&nbsp;\u201cOpaganib\u901a\u8fc7\u72ec\u7279\u7684\u53cc\u91cd\u6297\u75c5\u6bd2\u548c\u6297\u708e\u4f5c\u7528\u6a21\u5f0f\u5bf9\u65b0\u51a0\u80ba\u708e\u7684\u75c5\u56e0\u548c\u5f71\u54cd\u53d1\u6325\u4f5c\u7528\u3002Opaganib\u4ee5\u5bbf\u4e3b\u4e3a\u9776\u6807\uff0c\u6709\u671b\u6709\u6548\u5bf9\u6297\u65b0\u51fa\u73b0\u7684SARS-CoV-2\u53d8\u79cd\u3002\u8fd9\u4e9b\u75c5\u6bd2\u53d8\u79cd\u6301\u7eed\u5a01\u80c1\u7740\u6211\u4eec\u5728\u6297\u51fb\u75ab\u60c5\u65b9\u9762\u53d6\u5f97\u7684\u8fdb\u5c55\uff0c\u5e76\u4fc3\u4f7f\u6211\u4eec\u9762\u5bf9\u5bfb\u627e\u6709\u6548\u7684\u65b0\u51a0\u80ba\u708e\u7597\u6cd5\u7684\u7d27\u8feb\u6027\u3002&quot;<\/p>\n<p>\u6b64\u6b21\u5168\u7403\u5171\u6709475\u540d\u91cd\u75c7\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u53c2\u4e0e\u76842\/3\u671fopaganib\u7814\u7a76\u5df2\u572810\u4e2a\u56fd\u5bb6\u83b7\u5f97\u6279\u51c6\uff0c\u5e76\u5df2\u4e8e6\u67086\u65e5\u901a\u8fc757\u4e2a\u53c2\u4e0e\u7814\u7a76\u5730\u70b9\u5b8c\u6210\u62db\u52df\u5de5\u4f5c\u3002&nbsp;\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u5230\u7b2c14\u5929\u80fd\u547c\u5438\u5ba4\u5185\u7a7a\u6c14\u7684\u60a3\u8005\u6bd4\u4f8b\u3002\u7814\u7a76\u8fd8\u5c06\u5728\u6700\u957f6\u5468\u7684\u968f\u8bbf\u671f\u5185\u6536\u96c6\u5176\u4ed6\u91cd\u8981\u7684\u9884\u540e\u6307\u6807\uff0c\u4f8b\u5982\u51fa\u9662\u65f6\u95f4\u3001\u6839\u636e\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u4e34\u5e8a\u6539\u5584\u987a\u5e8f\u91cf\u8868\u7684\u6539\u5584\u60c5\u51b5\u4ee5\u53ca\u63d2\u7ba1\u53d1\u751f\u7387\u548c\u6b7b\u4ea1\u7387\u3002\u8be5\u9879\u7814\u7a76\u63a5\u53d7\u4e86\u56db\u9879\u72ec\u7acbDSMB\u5efa\u8bae\uff0c\u4ee5\u7ee7\u7eed\u540e\u7eed\u7684\u975e\u76f2\u6cd5\u5b89\u5168\u6027\u548c\u65e0\u6548\u6027\u5ba1\u67e5\u3002\u6b64\u5916\uff0c\u4e0e\u5927\u578b\u5e73\u53f0\u7814\u7a76\uff08\u5982RECOVERY\uff09\u548c\u5176\u4ed6\u7c7b\u4f3c\u60a3\u8005\u4eba\u7fa4\u7684\u7814\u7a76\u6240\u62a5\u544a\u7684\u6b7b\u4ea1\u7387\u76f8\u6bd4\uff0c\u8fc4\u4eca\u4e3a\u6b62\u5bf9\u76f2\u6cd5\u6df7\u5408\u63d2\u7ba1\u53d1\u751f\u7387\u548c\u6b7b\u4ea1\u7387\u7684\u8bc4\u4f30\u7ed3\u679c\u4ee4\u4eba\u9f13\u821e[3]\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Opaganib\u662f\u4e00\u79cd\u9886\u5148\u7684\u3001\u7528\u4e8e\u6cbb\u7597\u4e2d\u91cd\u5ea6\u65b0\u51a0\u80ba\u708e\u7684\u65b0\u578b\u53e3\u670d\u53cc\u673a\u5236\u5019\u9009\u836f\u7269\uff0c\u8be5\u836f\u7684\u7f8e\u56fd2\u671f\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7814\u7a76\u79ef\u6781\u6570\u636e\u5df2\u5728\u4e16\u754c\u5fae\u751f\u7269\u8bba\u575b\uff08World Microbe Forum\uff09\u4e0a\u53d1\u5e03&nbsp; Opaganib\u53ef\u51cf\u5c11\u60a3\u8005\u7684\u4f9b\u6c27\u9700\u6c42\u3001\u7f29\u77ed\u4f4f\u9662\u65f6\u95f4\u5e76\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027&nbsp; \u8fd9\u9879\u5171474\u540d\u60a3\u8005\u53c2\u4e0e\u7684Opaganib\u5168\u74032\/3\u671f\u7814\u7a76\u5df2\u5b8c\u6210\u62db\u52df\uff0c\u9884\u8ba1\u672a\u6765\u51e0\u5468\u5185\u5b8c\u6210\u7814\u7a76\u5de5\u4f5c&nbsp; Opaganib\u4ee5\u5bbf\u4e3b\u4e3a\u9776\u6807\uff0c\u6709\u671b\u6709\u6548\u5bf9\u6297\u65b0\u51fa\u73b0\u7684\u75c5\u6bd2\u53d8\u79cd&nbsp; \u4ee5\u8272\u5217\u7279\u62c9\u7ef4\u592b\u548c\u7f8e\u56fd\u5317\u5361\u7f57\u83b1\u7eb3\u5dde\u7f57\u52292021\u5e746\u670823\u65e5 \/\u7f8e\u901a\u793e\/ &#8212;&nbsp;\u7279\u79cd\u751f\u7269\u5236\u836f\u516c\u53f8RedHill Biopharma Ltd.\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aRDHL\uff09\uff08\u4ee5\u4e0b\u7b80\u79f0\u201cRedHill\u201d\u6216\u201c\u516c\u53f8\u201d\uff09\u4eca\u5929\u5ba3\u5e03\uff0c\u57282021\u5e74\u4e16\u754c\u5fae\u751f\u7269\u8bba\u575b\uff08WWF\uff09\u4e0a\u53d1\u5e03\u53e3\u670dopaganib\uff08Yeliva&reg;\uff0cABC294640\uff09\u76842\u671f\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u79ef\u6781\u6570\u636e[1]\uff08\u6d77\u62a5\u7f16\u53f7\uff1a5574\uff09\u3002 \u6d77\u62a5\u4ecb\u7ecd\u4e86\u7f8e\u56fd40\u540d\u60a3\u8005\u76842\u671f\u7814\u7a76\u7ed3\u679c\u548c\u540e\u7eed\u6570\u636e\u5206\u6790\uff0c\u5176\u6807\u9898\u4e3a\u300aOpaganib, an Oral Sphingosine Kinase-2 (SK2) Inhibitor in COVID-19 Pneumonia: A Randomized, Double-blind, Placebo-controlled Phase 2A Study, in Adult Subjects Hospitalized with SARS-CoV-2 Positive 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