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id=\"spanHghlt5e9a\"><b>E\uff1aEffective&#8211;\u75be\u75c5\u8fdb\u5c55\u98ce\u9669\u964d\u4f4e76%\uff0c<\/b><b>HOPES\u7814\u7a76\u5c55\u73b0\u4e2d\u56fd\u7814\u7a76\u8005\u98ce\u91c7<\/b><\/span><\/p>\n<p>\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u4f0a\u5c3c\u59a5\u5355\u6297\u4e5f\u8868\u73b0\u51fa\u4e86\u786e\u5207\u7684\u4e34\u5e8a\u7597\u6548\u3002\u5176\u6ce8\u518cIII\u671f\u4e34\u5e8a\u7814\u7a76 &#8212; HOPES\u7814\u7a76\u7684\u6210\u529f\u79bb\u4e0d\u5f00\u5b59\u71d5\u9662\u58eb\u3001\u6c5f\u6cfd\u98de\u6559\u6388\u7b49\u9876\u5c16\u4e2d\u56fd\u7814\u7a76\u8005\u7684\u5353\u8d8a\u667a\u6167\u4e0e\u8f9b\u52e4\u4ed8\u51fa\u3002<\/p>\n<p>HOPES\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u4f0a\u5c3c\u59a5\u5355\u6297+\u5316\u7597\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc71\u4e2a\u6216\u591a\u4e2a\u5316\u7597\u65b9\u6848\u7684HER2 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45.6%\uff0cp&lt;0.0001\uff09\u3002<\/p>\n<p>\u5176\u4e2d\uff0c\u5bf9\u4e8e\u672f\u540e\u521d\u59cb\u590d\u53d1\u8f6c\u79fb\u7684\u60a3\u8005\uff0c\u82e5\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u9488\u5bf9MBC\u7684\u5316\u7597\uff0c\u7ecf\u4f0a\u5c3c\u59a5\u5355\u6297+\u5316\u7597\u6cbb\u7597\u540e\uff0c\u60a3\u8005\u7684mPFS\u53ef\u8d85\u8fc711\u4e2a\u6708\uff0cORR\u4e3a61.5%\uff1bDCR\u4e3a93.9%\u3002<\/p>\n<p>\u4f0a\u5c3c\u59a5\u5355\u6297\u7684\u5f3a\u6548\u6e90\u4e8e\u5176\u72ec\u7279\u7684\u836f\u7406\u673a\u5236\u4f18\u52bf\u3002\u7814\u7a76\u663e\u793a\uff0c\u4f0a\u5c3c\u59a5\u5355\u6297\u7684Fab\u6bb5\u4e0e\u66f2\u59a5\u73e0\u5355\u6297\u4e00\u81f4\uff0c\u901a\u8fc7Fc\u6bb5\u4fee\u9970\u548c\u751f\u4ea7\u5de5\u827a\u4f18\u5316\uff0c\u5177\u6709\u66f4\u5f3aADCC\u6548\u5e94\uff0c\u66f4\u597d\u5730\u5b9e\u73b0\u4e86\u6297HER2\u5355\u6297\u836f\u7269\u7684\u6cbb\u7597\u76ee\u6807\u2014\u2014\u65e2\u53ef\u4ee5\u963b\u65adHER2\u901a\u8def\uff0c\u76f4\u63a5\u6291\u5236\u80bf\u7624\u7ec6\u80de\u589e\u6b96\u548c\u751f\u957f\uff1b\u53c8\u53ef\u4ee5\u8bf1\u5bfcADCC\u6548\u5e94\uff0c\u901a\u8fc7\u673a\u4f53\u514d\u75ab\u7cfb\u7edf\u8bc6\u522b\u548c\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u3002<\/p>\n<p><span 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