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id=\"spanHghlt8d94\">\u57282\u671f<\/span>\u7814\u7a76\u4e2d22\u4f8b\uff0892%\uff09\u53d1\u751f\u4e0e\u4efb\u4e00\u7814\u7a76\u836f\u7269\u76f8\u5173\u7684\u4e0d\u826f\u4e8b\u4ef6\uff0c\u5176\u4e2d3-4\u7ea7\u53d1\u751f\u7387\u4e3a29%\uff0c\u4e0e\u4efb\u4e00\u7814\u7a76\u836f\u7269\u6709\u5173\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u4e3a6\u4f8b\uff0825%\uff09\uff0c\u672a\u53d1\u751f\u5bfc\u81f4\u6b7b\u4ea1\u7684\u4e0d\u826f\u4e8b\u4ef6\u3002\u6839\u636e2\u671f\u90e8\u5206\u7684\u521d\u6b65\u5b89\u5168\u6027\u548c\u7597\u6548\u6570\u636e\uff0c\u7ecf\u5b89\u5168\u6027\u8bc4\u4f30\u59d4\u5458\u8ba8\u8bba\u540e\u5f00\u59cb3\u671f\u7814\u7a76\u3002<\/p>\n<p>\u622a\u81f3\u6570\u636e\u622a\u6b62\u65e5\u671f\uff082020\u5e748\u670815\u65e5\uff09\uff0c\u4fe1\u8fea\u5229\u5355\u6297-\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u7ec4\u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a10.0\u4e2a\u6708\uff08IQR 8.5-11.7\uff09\uff0c\u7d22\u62c9\u975e\u5c3c\u7ec4\u4e3a10.0\u4e2a\u6708\uff08IQR 8.4-11.7\uff09\uff1b\u4e0e\u7d22\u62c9\u975e\u5c3c\u7ec4\u76f8\u6bd4\uff0c\u72ec\u7acb\u5f71\u50cf\u5b66\u5ba1\u8bc4\u59d4\u5458\u4f1a\uff08IRRC\uff09\u8bc4\u4f30\u7684\u4fe1\u8fea\u5229\u5355\u6297-\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u7ec4\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e5f\u663e\u8457\u6539\u5584\uff08\u4e2d\u4f4d\u503c4.6\u4e2a\u6708[95%CI 4.1-5.7] vs.2.8\u4e2a\u6708[95%CI 2.7-3.2]\uff0c\u5206\u5c42HR 0.56[95%CI 0.46-0.70]\uff0cp&lt;0.0001\uff09\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder7275\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/1537103\/image_1.html\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/image_1-1347.jpg\" title=\"\u56feA\uff1a\u72ec\u7acb\u5f71\u50cf\u57fa\u4e8eRECIST V1.1\u8bc4\u4f30\u7684PFS Kaplan\u2013Meier\u66f2\u7ebf\u56fe[2]\" alt=\"\u56feA\uff1a\u72ec\u7acb\u5f71\u50cf\u57fa\u4e8eRECIST V1.1\u8bc4\u4f30\u7684PFS Kaplan\u2013Meier\u66f2\u7ebf\u56fe[2]\" \/><\/a><br \/><span>\u56feA\uff1a\u72ec\u7acb\u5f71\u50cf\u57fa\u4e8eRECIST V1.1\u8bc4\u4f30\u7684PFS Kaplan\u2013Meier\u66f2\u7ebf\u56fe[2]<\/span><\/p>\n<\/p><\/div>\n<p>\u5728\u603b\u751f\u5b58\u671f\u7684\u9996\u6b21\u671f\u4e2d\u5206\u6790\u4e2d\uff0c\u4e0e\u7d22\u62c9\u975e\u5c3c\u76f8\u6bd4\uff0c\u4fe1\u8fea\u5229\u5355\u6297-\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u7684\u603b\u751f\u5b58\u671f\u4e5f\u663e\u8457\u6539\u5584\uff08\u4e2d\u4f4d\u503c\u672a\u8fbe[95%CI \u672a\u8fbe\u2013\u672a\u8fbe] vs 10.4\u4e2a\u6708[94%CI 8.5-\u672a\u8fbe]\uff0cHR 0.57 [95%CI 0.43-0.75]\uff0cp&lt;0.0001\uff09\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder8232\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/1537101\/image_2.html\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/image_2-1125.jpg\" title=\"\u56feB:  ITT\u4eba\u7fa4Kaplan\u2013Meier\u751f\u5b58\u66f2\u7ebf\u56fe[3]\" alt=\"\u56feB:  ITT\u4eba\u7fa4Kaplan\u2013Meier\u751f\u5b58\u66f2\u7ebf\u56fe[3]\" \/><\/a><br \/><span>\u56feB: ITT\u4eba\u7fa4Kaplan\u2013Meier\u751f\u5b58\u66f2\u7ebf\u56fe[3]<\/span><\/p>\n<\/p><\/div>\n<p>\u6700\u5e38\u89c1\u76843-4\u7ea7\u6cbb\u7597\u671f\u95f4\u7684\u4e0d\u826f\u4e8b\u4ef6\u4e3a\u9ad8\u8840\u538b\uff08\u4fe1\u8fea\u5229\u5355\u6297-\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u7ec4380\u4f8b\u60a3\u8005\u4e2d55\u4f8b[14%]vs\u7d22\u62c9\u975e\u5c3c\u7ec4191\u4f8b\u60a3\u8005\u4e2d11\u4f8b[6%]\uff09\u548c\u638c\u8dd6\u7ea2\u80bf\u75bc\u75db\u7efc\u5408\u5f81\uff08\u65e0vs 22\u4f8b[12%]\uff09\u3002\u4fe1\u8fea\u5229\u5355\u6297-\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u7ec4123\u4f8b(32%)\u60a3\u8005\u548c\u7d22\u62c9\u975e\u5c3c\u7ec436\u4f8b\uff0819%\uff09\u60a3\u8005\u53d1\u751f\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff0c\u4e24\u7ec4\u4e0e\u4efb\u4e00\u7814\u7a76\u836f\u7269\u76f8\u5173\u7684\u5bfc\u81f4\u6b7b\u4ea1\u7684\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u5206\u522b\u4e3a6\u4f8b(2%)\u548c2\u4f8b(1%)\u3002<\/p>\n<p><b>\u7814\u7a76\u7ed3\u8bba<\/b><\/p>\n<p>\u4fe1\u8fea\u5229\u5355\u6297-\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u5728\u4e00\u7ebf\u6cbb\u7597\u4e0d\u53ef\u5207\u9664\u7684HBV\u76f8\u5173\u809d\u7ec6\u80de\u764c\u4e2d\u56fd\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u663e\u8457\u7684\u603b\u751f\u5b58\u671f\u548c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u83b7\u76ca\uff0c\u5177\u6709\u53ef\u63a5\u53d7\u7684\u5b89\u5168\u6027\u7279\u5f81\u3002\u8fd9\u4e2a\u8054\u5408\u7528\u836f\u65b9\u6848\u4e3a\u8be5\u7c7b\u60a3\u8005\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002<\/p>\n<p>\u53c2\u8003\u6587\u732e<\/p>\n<p>\u539f\u6587\u94fe\u63a5\uff1a<br \/><a target=\"_blank\" href=\"https:\/\/www.thelancet.com\/journals\/lanonc\/article\/PIIS1470-2045(21)00252-7\/fulltext\" rel=\"nofollow noopener\">https:\/\/www.thelancet.com\/journals\/lanonc\/article\/PIIS1470-2045(21)00252-7\/fulltext<\/a> <\/p>\n<p><b>\u5173\u4e8e\u809d\u764c<\/b><\/p>\n<p>\u809d\u764c\u662f\u5168\u4e16\u754c\u8303\u56f4\u5185\u5e38\u89c1\u7684\u6d88\u5316\u7cfb\u7edf\u6076\u6027\u80bf\u7624\uff0c\u4e2d\u56fd\u7684\u809d\u764c\u60a3\u8005\u5360\u5168\u7403\u6570\u91cf\u7684\u4e00\u534a\u5de6\u53f3\uff0c\u809d\u764c\u4e25\u91cd\u5730\u5a01\u80c1\u7740\u6211\u56fd\u4eba\u6c11\u7684\u751f\u547d\u548c\u5065\u5eb7\u3002\u809d\u764c\u7684\u75c5\u7406\u7c7b\u578b\u4e3b\u8981\u662f\u809d\u7ec6\u80de\u764c\uff08hepatocellular carcinoma\uff0cHCC\uff09\uff0c\u536085%~90%\uff1b\u8fd8\u6709\u5c11\u6570\u4e3a\u809d\u5185\u80c6\u7ba1\u764c\uff08intrahepatic cholangiocarcinoma\uff0cICC\uff09\u548cHCC-ICC \u6df7\u5408\u578b\u7b49\u3002\u5728\u6211\u56fd\uff0cHCC\u4e3b\u8981\u7531\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08hepatitis B virus\uff0cHBV\uff09\u548c\/\u6216\u4e19\u578b\u809d\u708e\u75c5\u6bd2\uff08hepatitis C virus\uff0cHCV\uff09\u611f\u67d3\u5f15\u8d77\u3002<\/p>\n<p><b>\u5173\u4e8e\u4fe1\u8fea\u5229\u5355\u6297<\/b><\/p>\n<p>\u4fe1\u8fea\u5229\u5355\u6297\uff0c\u4e2d\u56fd\u54c1\u724c\u540d\u4e3a\u8fbe\u4f2f\u8212<sup>&reg;<\/sup>\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff09\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u548c\u793c\u6765\u5236\u836f\u5171\u540c\u5408\u4f5c\u7814\u53d1\u7684\u5177\u6709\u56fd\u9645\u54c1\u8d28\u7684\u521b\u65b0PD-1\u6291\u5236\u5242\u836f\u7269\u3002\u4fe1\u8fea\u5229\u5355\u6297\u662f\u4e00\u79cd\u4eba\u7c7b\u514d\u75ab\u7403\u86cb\u767dG4\uff08IgG4\uff09\u5355\u514b\u9686\u6297\u4f53\uff0c\u80fd\u7279\u5f02\u6027\u7ed3\u5408T\u7ec6\u80de\u8868\u9762\u7684PD-1\u5206\u5b50\uff0c\u4ece\u800c\u963b\u65ad\u5bfc\u81f4\u80bf\u7624\u514d\u75ab\u8010\u53d7\u7684 PD-1\/\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f53\u914d\u4f531\uff08Programmed Death-Ligand 1, PD-L1\uff09\u901a\u8def\uff0c\u91cd\u65b0\u6fc0\u6d3b\u6dcb\u5df4\u7ec6\u80de\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u4ece\u800c\u8fbe\u5230\u6cbb\u7597\u80bf\u7624\u7684\u76ee\u7684\u3002\u76ee\u524d\u6709\u8d85\u8fc7\u4e8c\u5341\u591a\u4e2a\u4e34\u5e8a\u7814\u7a76\uff08\u5176\u4e2d10\u591a\u9879\u662f\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\uff09\u6b63\u5728\u8fdb\u884c\uff0c\u4ee5\u8bc4\u4f30\u4fe1\u8fea\u5229\u5355\u6297\u5728\u5404\u7c7b\u5b9e\u4f53\u80bf\u7624\u548c\u8840\u6db2\u80bf\u7624\u4e0a\u7684\u6297\u80bf\u7624\u4f5c\u7528\u3002\u4fe1\u8fbe\u751f\u7269\u540c\u65f6\u6b63\u5728\u5168\u7403\u5f00\u5c55\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\u7684\u4e34\u5e8a\u7814\u7a76\u5de5\u4f5c\u3002<\/p>\n<p>\u4fe1\u8fea\u5229\u5355\u6297\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u4e09\u9879\u9002\u5e94\u75c7\uff0c\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u7528\u4e8e\u6cbb\u7597\u81f3\u5c11\u7ecf\u8fc7\u4e8c\u7ebf\u7cfb\u7edf\u5316\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624 <\/li>\n<li>\u8054\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u94c2\u7c7b\u5316\u7597\u7528\u4e8eEGFR\u6216ALK\u9634\u6027\u7684\u665a\u671f\u975e\u9cde\u72b6NSCLC\u7684\u4e00\u7ebf\u6cbb\u7597 <\/li>\n<li>&nbsp;\u8054\u5408\u5409\u897f\u4ed6\u6ee8\u548c\u94c2\u7c7b\u5316\u7597\u9002\u7528\u4e8e\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u9cde\u72b6NSCLC\u7684\u4e00\u7ebf\u6cbb\u7597<\/li>\n<\/ul>\n<p>\u4fe1\u8fea\u5229\u5355\u6297\u53e6\u6709\u4e24\u9879\u4e0a\u5e02\u7533\u8bf7\u5df2\u83b7\u4e2d\u56fd\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u53d7\u7406\u5ba1\u8bc4\uff0c\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u8054\u5408\u8fbe\u6538\u540c<sup>&reg;<\/sup>\uff08\u8d1d\u4f10\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u7528\u4e8e\u809d\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597 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Anderson \u764c\u75c7\u4e2d\u5fc3\u548c\u97e9\u56fdHanmi\u7b49\u56fd\u9645\u5408\u4f5c\u65b9\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u3002\u4fe1\u8fbe\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u56fd\u751f\u7269\u5236\u836f\u4ea7\u4e1a\u7684\u53d1\u5c55\u6c34\u5e73\uff0c\u4ee5\u6ee1\u8db3\u767e\u59d3\u7528\u836f\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5bf9\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u613f\u671b\u7684\u8ffd\u6c42\u3002\u8be6\u60c5\u8bf7\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9\uff1a<a target=\"_blank\" href=\"http:\/\/www.innoventbio.com\/\" rel=\"nofollow noopener\">www.innoventbio.com<\/a>\u3002<\/p>\n<p><b><span id=\"spanHghltf80f\">\u524d\u77bb\u6027\u58f0\u660e<\/span><\/b><\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u6240\u53d1\u5e03\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u4f1a\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u8fd9\u4e9b\u8868\u8ff0\u672c\u8d28\u4e0a\u5177\u6709\u76f8\u5f53\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u3002\u5728\u4f7f\u7528\u201c\u9884\u671f\u201d\u3001\u201c\u76f8\u4fe1\u201d\u3001\u201c\u9884\u6d4b\u201d\u3001\u201c\u671f\u671b\u201d\u3001\u201c\u6253\u7b97\u201d\u53ca\u5176\u4ed6\u7c7b\u4f3c\u8bcd\u8bed\u8fdb\u884c\u8868\u8ff0\u65f6\uff0c\u51e1\u4e0e\u672c\u516c\u53f8\u6709\u5173\u7684\uff0c\u76ee\u7684\u5747\u662f\u8981\u6307\u660e\u5176\u5c5e\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u5e76\u65e0\u4e49\u52a1\u4e0d\u65ad\u5730\u66f4\u65b0\u8fd9\u4e9b\u9884\u6d4b\u6027\u9648\u8ff0\u3002<\/p>\n<p>\u8fd9\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u4e8e\u672c\u516c\u53f8\u7ba1\u7406\u5c42\u5728\u505a\u51fa\u8868\u8ff0\u65f6\u5bf9\u672a\u6765\u4e8b\u52a1\u7684\u73b0\u6709\u770b\u6cd5\u3001\u5047\u8bbe\u3001\u671f\u671b\u3001\u4f30\u8ba1\u3001\u9884\u6d4b\u548c\u7406\u89e3\u3002\u8fd9\u4e9b\u8868\u8ff0\u5e76\u975e\u5bf9\u672a\u6765\u53d1\u5c55\u7684\u4fdd\u8bc1\uff0c\u4f1a\u53d7\u5230\u98ce\u9669\u3001\u4e0d\u786e\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u8303\u56f4\uff0c\u96be\u4ee5\u9884\u8ba1\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u4eec\u7684\u4e1a\u52a1\u3001\u7ade\u4e89\u73af\u5883\u3001\u653f\u6cbb\u3001\u7ecf\u6d4e\u3001\u6cd5\u5f8b\u548c\u793e\u4f1a\u60c5\u51b5\u7684\u672a\u6765\u53d8\u5316\u53ca\u53d1\u5c55\u7684\u5f71\u54cd\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4f1a\u4e0e\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8d44\u6599\u6709\u8f83\u5927\u5dee\u522b\u3002<\/p>\n[1]1. <i>Chen W, Zheng R, Baade PD, et al. Cancer statistics in <span class=\"xn-location\">China<\/span>, 2015; CA Cancer J Clin 2016; 66: 115-32. <br \/><\/i><i>2. Xie DY, Ren ZG, Zhou J, Fan J, Gao Q. 2019 Chinese clinical guidelines for the management of hepatocellular carcinoma: updates and insights. Hepatobiliary Surg Nutr. 2020 Aug;9(4):452-463. doi: 10.21037\/hbsn-20-480.<\/i><\/p>\n[2][3]Reprinted from <i>The Lancet<\/i>, <a href=\"https:\/\/doi.org\/10.1016\/S1470-2045\" rel=\"nofollow\">https:\/\/doi.org\/10.1016\/S1470-2045<\/a>(21)00252-7, Prof <span class=\"xn-person\">Zhenggang Ren<\/span>, MD, Prof <span class=\"xn-person\">Jianming Xu<\/span>, MD, Prof <span class=\"xn-person\">Yuxian Bai<\/span>, MD, Prof <span class=\"xn-person\">Aibing Xu<\/span>, MD, Prof Shundong Cang, MD, Prof Chengyou Du, MD, et al., Sintilimab plus a bevacizumab biosimilar (IBI305) versus sorafenib in unresectable hepatocellular carcinoma (ORIENT-32): a randomised, open-label, phase 2\u20133 study, Copyright (2021), with permission from Elsevier<\/p>\n<p>&nbsp;<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder0\">  <\/div>\n<p>\u76f8\u5173\u94fe\u63a5 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\u622a\u81f3\u6570\u636e\u622a\u6b62\u65e5\u671f\uff082020\u5e748\u670815\u65e5\uff09\uff0c\u4fe1\u8fea\u5229\u5355\u6297-\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u7ec4\u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a10.0\u4e2a\u6708\uff08IQR 8.5-11.7\uff09\uff0c\u7d22\u62c9\u975e\u5c3c\u7ec4\u4e3a10.0\u4e2a\u6708\uff08IQR 8.4-11.7\uff09\uff1b\u4e0e\u7d22\u62c9\u975e\u5c3c\u7ec4\u76f8\u6bd4\uff0c\u72ec\u7acb\u5f71\u50cf\u5b66\u5ba1\u8bc4\u59d4\u5458\u4f1a\uff08IRRC\uff09\u8bc4\u4f30\u7684\u4fe1\u8fea\u5229\u5355\u6297-\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u7ec4\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e5f\u663e\u8457\u6539\u5584\uff08\u4e2d\u4f4d\u503c4.6\u4e2a\u6708[95%CI 4.1-5.7] vs.2.8\u4e2a\u6708[95%CI 2.7-3.2]\uff0c\u5206\u5c42HR 0.56[95%CI 0.46-0.70]\uff0cp&lt;0.0001\uff09\u3002 \u56feA\uff1a\u72ec\u7acb\u5f71\u50cf\u57fa\u4e8eRECIST V1.1\u8bc4\u4f30\u7684PFS Kaplan\u2013Meier\u66f2\u7ebf\u56fe[2] \u5728\u603b\u751f\u5b58\u671f\u7684\u9996\u6b21\u671f\u4e2d\u5206\u6790\u4e2d\uff0c\u4e0e\u7d22\u62c9\u975e\u5c3c\u76f8\u6bd4\uff0c\u4fe1\u8fea\u5229\u5355\u6297-\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u7684\u603b\u751f\u5b58\u671f\u4e5f\u663e\u8457\u6539\u5584\uff08\u4e2d\u4f4d\u503c\u672a\u8fbe[95%CI \u672a\u8fbe\u2013\u672a\u8fbe] vs 10.4\u4e2a\u6708[94%CI 8.5-\u672a\u8fbe]\uff0cHR 0.57 [95%CI 0.43-0.75]\uff0cp&lt;0.0001\uff09\u3002 \u56feB: ITT\u4eba\u7fa4Kaplan\u2013Meier\u751f\u5b58\u66f2\u7ebf\u56fe[3] \u6700\u5e38\u89c1\u76843-4\u7ea7\u6cbb\u7597\u671f\u95f4\u7684\u4e0d\u826f\u4e8b\u4ef6\u4e3a\u9ad8\u8840\u538b\uff08\u4fe1\u8fea\u5229\u5355\u6297-\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u7ec4380\u4f8b\u60a3\u8005\u4e2d55\u4f8b[14%]vs\u7d22\u62c9\u975e\u5c3c\u7ec4191\u4f8b\u60a3\u8005\u4e2d11\u4f8b[6%]\uff09\u548c\u638c\u8dd6\u7ea2\u80bf\u75bc\u75db\u7efc\u5408\u5f81\uff08\u65e0vs 22\u4f8b[12%]\uff09\u3002\u4fe1\u8fea\u5229\u5355\u6297-\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u7ec4123\u4f8b(32%)\u60a3\u8005\u548c\u7d22\u62c9\u975e\u5c3c\u7ec436\u4f8b\uff0819%\uff09\u60a3\u8005\u53d1\u751f\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff0c\u4e24\u7ec4\u4e0e\u4efb\u4e00\u7814\u7a76\u836f\u7269\u76f8\u5173\u7684\u5bfc\u81f4\u6b7b\u4ea1\u7684\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u5206\u522b\u4e3a6\u4f8b(2%)\u548c2\u4f8b(1%)\u3002 \u7814\u7a76\u7ed3\u8bba \u4fe1\u8fea\u5229\u5355\u6297-\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u5728\u4e00\u7ebf\u6cbb\u7597\u4e0d\u53ef\u5207\u9664\u7684HBV\u76f8\u5173\u809d\u7ec6\u80de\u764c\u4e2d\u56fd\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u663e\u8457\u7684\u603b\u751f\u5b58\u671f\u548c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u83b7\u76ca\uff0c\u5177\u6709\u53ef\u63a5\u53d7\u7684\u5b89\u5168\u6027\u7279\u5f81\u3002\u8fd9\u4e2a\u8054\u5408\u7528\u836f\u65b9\u6848\u4e3a\u8be5\u7c7b\u60a3\u8005\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002 \u53c2\u8003\u6587\u732e \u539f\u6587\u94fe\u63a5\uff1ahttps:\/\/www.thelancet.com\/journals\/lanonc\/article\/PIIS1470-2045(21)00252-7\/fulltext \u5173\u4e8e\u809d\u764c \u809d\u764c\u662f\u5168\u4e16\u754c\u8303\u56f4\u5185\u5e38\u89c1\u7684\u6d88\u5316\u7cfb\u7edf\u6076\u6027\u80bf\u7624\uff0c\u4e2d\u56fd\u7684\u809d\u764c\u60a3\u8005\u5360\u5168\u7403\u6570\u91cf\u7684\u4e00\u534a\u5de6\u53f3\uff0c\u809d\u764c\u4e25\u91cd\u5730\u5a01\u80c1\u7740\u6211\u56fd\u4eba\u6c11\u7684\u751f\u547d\u548c\u5065\u5eb7\u3002\u809d\u764c\u7684\u75c5\u7406\u7c7b\u578b\u4e3b\u8981\u662f\u809d\u7ec6\u80de\u764c\uff08hepatocellular carcinoma\uff0cHCC\uff09\uff0c\u536085%~90%\uff1b\u8fd8\u6709\u5c11\u6570\u4e3a\u809d\u5185\u80c6\u7ba1\u764c\uff08intrahepatic cholangiocarcinoma\uff0cICC\uff09\u548cHCC-ICC&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2021062107000034745\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":34749,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-34745","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/34745","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=34745"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/34745\/revisions"}],"predecessor-version":[{"id":34748,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/34745\/revisions\/34748"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/34749"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=34745"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=34745"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=34745"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}