{"id":33957,"date":"2021-06-11T14:00:00","date_gmt":"2021-06-11T07:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021061114000033957"},"modified":"2021-06-11T21:50:03","modified_gmt":"2021-06-11T13:50:03","slug":"%e7%99%be%e6%b5%8e%e7%a5%9e%e5%b7%9e%e5%9c%a8eha2021%e5%b9%b4%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83%e7%99%be%e6%82%a6%e6%b3%bd%ef%bc%88r%ef%bc%89%ef%bc%88%e6%b3%bd%e5%b8%83%e6%9b%bf%e5%b0%bc%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021061114000033957","title":{"rendered":"\u767e\u6d4e\u795e\u5dde\u5728EHA2021\u5e74\u4f1a\u4e0a\u516c\u5e03\u767e\u60a6\u6cfd\uff08R\uff09\uff08\u6cfd\u5e03\u66ff\u5c3c\uff09\u548c\u767e\u6cfd\u5b89\uff08R\uff09\uff08\u66ff\u96f7\u5229\u73e0\u5355\u6297\uff09\u76843\u9879\u5173\u952e\u6027\u4e34\u5e8a\u8bd5\u9a8c\u7684\u957f\u671f\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u7ed3\u679c"},"content":{"rendered":"

\u5728\u8fd1<\/i>3<\/i>\u5e74\u7684\u957f\u671f\u968f\u8bbf\u4e2d\uff0c\u767e\u60a6\u6cfd<\/i>®<\/sup><\/i>\u5728\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\u548c\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u60a3\u8005\u4e2d\u663e\u793a\u4e86\u957f\u671f\u4e34\u5e8a\u83b7\u76ca\u548c\u8010\u53d7\u6027<\/i><\/p>\n

\u5728<\/i>34<\/i>\u4e2a\u6708\u968f\u8bbf\u65f6\uff0c\u767e\u6cfd\u5b89<\/i>®<\/sup><\/i>\u5728\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u4e2d\u83b7\u5f97\u4e86\u6df1\u5ea6\u548c\u6301\u4e45\u7684\u7f13\u89e3\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u8fbe\u5230<\/i>32<\/i>\u4e2a\u6708\uff0c\u672a\u51fa\u73b0\u65b0\u7684\u5b89\u5168\u8b66\u793a<\/i><\/p>\n

\u516c\u53f8\u5c06\u4e8e\u5317\u4eac\u65f6\u95f4<\/i>6<\/i>\u6708<\/i>12<\/i>\u65e5\uff08\u5468\u516d\uff09\u96f6\u70b9\uff08\u7f8e\u4e1c\u65f6\u95f4<\/i>6<\/i>\u6708<\/i>11<\/i>\u65e5\u4e2d\u5348<\/i>12<\/i>\u70b9\uff09\u53ec\u5f00\u7ebf\u4e0a\u6295\u8d44\u8005\u4f1a\u8bae<\/i><\/p>\n

\u7f8e\u56fd\u9ebb\u7701\u5251\u6865\u548c\u4e2d\u56fd\u5317\u4eac2021\u5e746\u670811\u65e5 \/\u7f8e\u901a\u793e\/ — \u767e\u6d4e\u795e\u5dde<\/a>\uff08\u7eb3\u65af\u8fbe\u514b\u4ee3\u7801\uff1aBGNE\uff1b\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a06160\uff09\uff0c\u662f\u4e00\u5bb6\u5904\u4e8e\u5546\u4e1a\u9636\u6bb5\u7684\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5728\u4e16\u754c\u8303\u56f4\u5185\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u521b\u65b0\u836f\u7269\u3002\u516c\u53f8\u4eca\u65e5\u5ba3\u5e03\u57282021\u5e74\u7b2c26\u5c4a\u6b27\u6d32\u8840\u6db2\u5b66\u534f\u4f1a\uff08EHA2021\uff09\u7ebf\u4e0a\u5927\u4f1a\u4e0a\u516c\u5e03\u5176\u8840\u6db2\u5b66\u9879\u76ee\u4e2d\u7684\u4e09\u9879\u5173\u952e\u8bd5\u9a8c\u7684\u957f\u671f\u968f\u8bbf\u7ed3\u679c\uff0c\u5305\u62ec\u53e3\u5934\u62a5\u544a\u6297PD-1\u6297\u4f53\u836f\u7269\u767e\u6cfd\u5b89®<\/sup>\uff08\u66ff\u96f7\u5229\u73e0\u5355\u6297\uff09\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u6027\uff08R\/R\uff09\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08cHL\uff09\u76842\u671f\u8bd5\u9a8c\u6570\u636e\uff0c\u6d77\u62a5\u5c55\u793a\u4e24\u9879BTK\u6291\u5236\u5242\u767e\u60a6\u6cfd®<\/sup>\uff08\u6cfd\u5e03\u66ff\u5c3c\uff09\u7528\u4e8e\u6cbb\u7597R\/R\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u548cR\/R\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u6216\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08SLL\uff09\u76842\u671f\u8bd5\u9a8c\u6570\u636e\u3002<\/p>\n

\u767e\u6d4e\u795e\u5dde\u8840\u6db2\u5b66\u9996\u5e2d\u533b\u5b66\u5b98\u9ec4\u851a\u5a1f\u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a\u201c\u6211\u4eec\u975e\u5e38\u9ad8\u5174\u770b\u5230\u767e\u6cfd\u5b89®<\/sup>\u548c\u767e\u60a6\u6cfd®<\/sup>\u5728\u8fd9\u4e9b\u5173\u952e\u6027\u8bd5\u9a8c\u4e2d\u4e3a\u60a3\u8005\u5e26\u6765\u957f\u671f\u4e34\u5e8a\u83b7\u76ca\uff0c\u8fd9\u4e3a\u4e24\u6b3e\u4ea7\u54c1\u5728\u4e2d\u56fd\u83b7\u5f97\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u6027cHL\u548cCLL\u6216SLL\u60a3\u8005\uff0c\u4ee5\u53ca\u767e\u60a6\u6cfd®<\/sup>\u5728\u7f8e\u56fd\u548c\u4e2d\u56fd\u83b7\u5f97\u6279\u51c6\u7528\u4e8eMCL\u60a3\u8005\u63d0\u4f9b\u4e86\u652f\u6301\u3002\u7814\u7a76\u663e\u793a\uff0c\u968f\u7740\u6cbb\u7597\u65f6\u95f4\u5ef6\u957f\uff0c\u767e\u6cfd\u5b89®<\/sup>\u8fbe\u5230\u4e86\u66f4\u9ad8\u7684\u5b8c\u5168\u7f13\u89e3\u7387\uff0c\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u8b66\u793a\uff0c\u800c\u6df1\u5ea6\u7f13\u89e3\u4e5f\u8f6c\u6362\u6210\u4e86\u4e0d\u4fd7\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u7ed3\u679c\u3002\u800c\u5728\u4e24\u9879\u767e\u60a6\u6cfd®<\/sup>\u7684\u8bd5\u9a8c\u4e2d\uff0c\u6211\u4eec\u7684\u9ad8\u9009\u62e9\u6027\u65b0\u4e00\u4ee3BTK\u6291\u5236\u5242\u6301\u7eed\u5e26\u6765\u4e86\u6df1\u5ea6\u7684\u75be\u75c5\u7f13\u89e3\uff0c\u5e76\u5728\u8fd9\u4e9b\u60a3\u8005\u4e2d\u4ea7\u751f\u4e86\u826f\u597d\u7684\u8010\u53d7\u6027\u3002\u968f\u7740\u767e\u6d4e\u795e\u5dde\u7ee7\u7eed\u5728\u5168\u7403\u5e03\u5c40\uff0c\u6211\u4eec\u5c06\u4e00\u5982\u65e2\u5f80\u5730\u52aa\u529b\u5c06\u8fd9\u4e9b\u91cd\u8981\u7597\u6cd5\u5e26\u7ed9\u66f4\u591a\u6709\u9700\u8981\u7684\u60a3\u8005\u3002\u201d<\/p>\n

\u767e\u6cfd\u5b89®<\/sup>\u6cbb\u7597R\/R cHL\u7684\u957f\u671f\u968f\u8bbf\u7ed3\u679c<\/b><\/p>\n

\u53e3\u5934\u62a5\u544a\uff1b\u6458\u8981\u4ee3\u7801\uff1a<\/i>S207<\/i><\/p>\n

\u8fd9\u9879\u5355\u81c2\u3001\u591a\u4e2d\u5fc3\u3001\u5173\u952e\u60272\u671f\u8bd5\u9a8c\uff08NCT03209973\uff09\u768434\u4e2a\u6708\u968f\u8bbf\u7ed3\u679c\u8868\u660e\uff0c\u767e\u6cfd\u5b89®<\/sup>\u7528\u4e8eR\/R cHL\u60a3\u8005\u7684\u6cbb\u7597\u5177\u6709\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d\u3002\u8fd9\u9879\u5173\u952e\u60272\u671f\u8bd5\u9a8c\u7684\u7ed3\u679c<\/a>\u652f\u6301\u767e\u6cfd\u5b89®<\/sup>\u4e8e2019\u5e7412\u6708\u5728\u4e2d\u56fd\u83b7\u5f97\u9644\u6761\u4ef6\u6279\u51c6<\/a>\u7528\u4e8e\u6cbb\u7597\u81f3\u5c11\u7ecf\u8fc7\u4e8c\u7ebf\u7cfb\u7edf\u5316\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027cHL\u60a3\u8005\u3002 <\/p>\n

\u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662\u6dcb\u5df4\u7624\u79d1\u4e3b\u6cbb\u533b\u5e08\u3001\u526f\u4e3b\u4efb\u533b\u5e08\u3001\u8bd5\u9a8c\u4e3b\u8981\u7814\u7a76\u8005\u5b8b\u7389\u7434\u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a\u201c\u5c3d\u7ba1\u65e2\u5f80\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5728R\/R cHL\u6cbb\u7597\u65b9\u9762\u53d6\u5f97\u4e86\u8fdb\u5c55\uff0c\u4f46\u53ea\u6709\u5c11\u6570\u60a3\u8005\u80fd\u591f\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\u3002\u598234\u4e2a\u6708\u968f\u8bbf\u7ed3\u679c\u6240\u793a\uff0c\u65e0\u8bba\u4e9a\u7ec4\u7279\u5f81\u5982\u4f55\uff0c\u767e\u6cfd\u5b89®<\/sup>\u5728\u8fd9\u4e9b\u60a3\u8005\u4e2d\u5747\u5e26\u6765\u4e86\u6df1\u5ea6\u3001\u6301\u4e45\u548c\u6301\u7eed\u7684\u7f13\u89e3\uff0c\u8fd170%\u7684\u60a3\u8005\u53d6\u5f97\u4e86\u5b8c\u5168\u7f13\u89e3\u3002\u6211\u4eec\u76f8\u4fe1\u8fd9\u4e00NMPA\u6279\u51c6\u7684\u514d\u75ab\u6cbb\u7597\u836f\u7269\u80fd\u591f\u4e3a\u4e2d\u56fd\u7684R\/R cHL\u60a3\u8005\u5e26\u6765\u6301\u7eed\u7684\u4e34\u5e8a\u83b7\u76ca\u3002\u201d<\/p>\n

\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a34\u4e2a\u6708\u65f6\uff0c\u5728\u6240\u6709\u60a3\u8005\u4e9a\u7ec4\u7684R\/R cHL\u60a3\u8005\u4e2d\uff0c\u767e\u6cfd\u5b89®<\/sup>\u5747\u8868\u73b0\u51fa\u6df1\u5ea6\u548c\u6301\u4e45\u7684\u7f13\u89e3\u3002\u7ecfIRC\u8bc4\u4f30\u7684\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a87.1%\uff0895%CI\uff1a77.0\uff0c93.9\uff09\uff0c\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\u7387\u4e3a67.1%\uff0895% CI\uff1a54.9, 77.9\uff09\u3002\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u968f\u8bbf\u65f6\u95f4\u4e3a31.5\u4e2a\u6708\uff0895% CI\uff1a16.53\uff0c\u4e0d\u53ef\u4f30\u8ba1[NE]\uff09\uff0c\u9884\u4f30\u768424\u4e2a\u6708\u548c36\u4e2a\u6708\u65e0\u8fdb\u5c55\u751f\u5b58\u7387\u5206\u522b\u4e3a55.4%\uff0895% CI\uff1a42.2\uff0c66.8\uff09\u548c40.8%\uff0895% CI: 25.2\uff0c55.8\uff09 \u3002\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08OS\uff09\u672a\u8fbe\u5230\uff0c24\u4e2a\u6708\u548c36\u4e2a\u6708\u7684OS\u7387\u4e3a93.9%\uff0895% CI\uff1a84.5\uff0c97.7\uff09\u548c84.8%\uff0895% CI: 70.5\uff0c92.6\uff09\u3002<\/p>\n

\u5728\u957f\u671f\u6cbb\u7597\u4e0b\uff0c\u767e\u6cfd\u5b89®<\/sup>\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d\uff0c\u5927\u591a\u6570\u4e0d\u826f\u4e8b\u4ef6\u4e3a1\u81f32\u7ea7\uff0c\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u8b66\u793a\u3002\u4efb\u4f55\u7ea7\u522b\u6cbb\u7597\u4e2d\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TEAE\uff09\u572897.1%\u7684\u60a3\u8005\u4e2d\u51fa\u73b0\uff0c3\u7ea7\u53ca\u4ee5\u4e0aTEAE\u572841.1%\u7684\u60a3\u8005\u4e2d\u51fa\u73b0\uff0c8.6%\u7684\u60a3\u8005\u56e0TEAE\u800c\u7ec8\u6b62\u6cbb\u7597\u3002<\/p>\n

\u767e\u60a6\u6cfd®<\/sup>\u6cbb\u7597R\/R MCL\u7684\u957f\u671f\u968f\u8bbf\u7ed3\u679c<\/b><\/p>\n

\u6d77\u62a5\u62a5\u544a\uff1b\u6458\u8981\u4ee3\u7801\uff1a<\/i>EP789<\/i><\/p>\n

\u5355\u81c2\u3001\u5f00\u653e\u6027\u3001\u591a\u4e2d\u5fc3\u5173\u952e\u60272\u671f\u8bd5\u9a8c\uff08NCT03206970\uff09\u768435\u4e2a\u6708\u968f\u8bbf\u7ed3\u679c\u663e\u793a\u4e86\u767e\u60a6\u6cfd®<\/sup>\u5bf9R\/R MCL\u60a3\u8005\u7684\u957f\u671f\u83b7\u76ca\u548c\u8010\u53d7\u6027\u3002\u8fd9\u9879\u5173\u952e\u60272\u671f\u8bd5\u9a8c\u7684\u7ed3\u679c<\/a>\u5305\u542b\u652f\u6301\u767e\u60a6\u6cfd®<\/sup>2019\u5e7411\u6708\u5728\u7f8e\u56fd\u83b7\u5f97\u52a0\u901f\u6279\u51c6<\/a>\u548c2020\u5e746\u6708\u5728\u4e2d\u56fd\u83b7\u5f97\u9644\u6761\u4ef6\u6279\u51c6<\/a>\u7528\u4e8e\u8be5\u9002\u5e94\u75c7\u7684\u6570\u636e\u3002<\/p>\n

\u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662\u6dcb\u5df4\u7624\u79d1\u4e3b\u6cbb\u533b\u5e08\u3001\u526f\u4e3b\u4efb\u533b\u5e08\u3001\u8bd5\u9a8c\u4e3b\u8981\u7814\u7a76\u8005\u5b8b\u7389\u7434\u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a\u201c\u7ecf\u8fc7\u8fd13\u5e74\u7684\u60a3\u8005\u968f\u8bbf\uff0c\u767e\u60a6\u6cfd®<\/sup>\u5728R\/R MCL\u60a3\u8005\u4e2d\u4fdd\u6301\u4e86\u8f83\u9ad8\u7684\u7f13\u89e3\u7387\uff0c\u5e76\u4e14\u968f\u7740\u6cbb\u7597\u65f6\u95f4\u7684\u5ef6\u957f\uff0c\u5b89\u5168\u6027\u6307\u6807\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u4fdd\u6301\u4e86\u7a33\u5b9a\u3002\u6211\u4eec\u5e0c\u671b\u8fd9\u4e9b\u4ee4\u4eba\u9f13\u821e\u7684\u7ed3\u679c\uff0c\u80fd\u8fdb\u4e00\u6b65\u786e\u7acb\u8fd9\u4e00\u9ad8\u9009\u62e9\u6027BTK\u6291\u5236\u5242\u6210\u4e3a\u5728\u5df2\u6279\u51c6\u5730\u533a\u4e2d\u5bf9R\/R MCL\u60a3\u8005\u7684\u9996\u9009\u6cbb\u7597\u65b9\u6848\u3002\u201d<\/p>\n

\u5728\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a35.3\u4e2a\u6708\u3001\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a27.6\u4e2a\u6708\u65f6\uff0c\u767e\u60a6\u6cfd®<\/sup>\u5728R\/R MCL\u60a3\u8005\u4e2d\u8868\u73b0\u51fa\u9ad8\u6548\u3001\u6df1\u5ea6\u548c\u6301\u7eed\u7684\u6709\u6548\u6027\uff0c\u4e14\u5404\u4e9a\u7ec4\u60a3\u8005\u53d6\u5f97\u7684\u7f13\u89e3\u7387\u5927\u4f53\u4e00\u81f4\u3002\u7ecf\u7814\u7a76\u8005\u8bc4\u4f30\u7684ORR\u4e3a83.7%\uff0895% CI\uff1a74.2\uff0c90.8\uff09\uff0c\u5305\u62ec67\u4f8b\u60a3\u8005\uff0877.9%\uff09\u8fbe\u5230CR\u3002\u4e2d\u4f4dPFS\u4e3a33.0\u4e2a\u6708\uff0895% CI\uff1a19.4\uff0cNE\uff09\uff0c\u9884\u4f30\u768436\u4e2a\u6708\u65e0\u8fdb\u5c55\u751f\u5b58\u7387\u4e3a47.6%\uff0895% CI\uff1a36.2\uff0c58.1\uff09\u3002<\/p>\n

\u968f\u7740\u957f\u671f\u968f\u8bbf\uff0c\u767e\u60a6\u6cfd®<\/sup>\u7684\u5b89\u5168\u6027\u6307\u6807\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u4fdd\u6301\u4e86\u7a33\u5b9a\u3002\u5927\u90e8\u5206\u4e0d\u826f\u4e8b\u4ef6\u51fa\u73b0\u5728\u65e9\u671f\u6cbb\u7597\u9636\u6bb5\uff0c\u672a\u56e0TEAE\u51fa\u73b0\u989d\u5916\u7684\u5242\u91cf\u964d\u4f4e\u3001\u6cbb\u7597\u7ec8\u6b62\u6216\u6b7b\u4ea1\u30023\u7ea7\u53ca\u4ee5\u4e0aTEAE\u51fa\u73b0\u572850.0%\u7684\u60a3\u8005\u4e2d\u3002<\/p>\n

\u767e\u60a6\u6cfd®<\/sup>\u6cbb\u7597R\/R CLL\u6216SLL\u7684\u957f\u671f\u968f\u8bbf\u7ed3\u679c<\/b><\/p>\n

\u6d77\u62a5\u62a5\u544a\uff1b\u6458\u8981\u4ee3\u7801\uff1a<\/i>EP639<\/i><\/p>\n

\u57fa\u4e8e\u5355\u81c2\u3001\u5f00\u653e\u6027\u3001\u591a\u4e2d\u5fc3\u5173\u952e\u60272\u671f\u8bd5\u9a8c\uff08NCT03206918\uff09\u768434\u4e2a\u6708\u968f\u8bbf\u7ed3\u679c\uff0c\u65e0\u8bba\u4e9a\u7ec4\u7279\u5f81\u5982\u4f55\uff0c\u767e\u60a6\u6cfd®<\/sup>\u4ecd\u5728R\/R CLL\u60a3\u8005\u4e2d\u8868\u73b0\u51fa\u6df1\u5ea6\u548c\u6301\u4e45\u7684\u7f13\u89e3\uff0c\u4e14\u8010\u53d7\u6027\u826f\u597d\uff0c\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u8b66\u793a\u3002\u8fd9\u9879\u5173\u952e\u60272\u671f\u8bd5\u9a8c\u7684\u7ed3\u679c<\/a>\u652f\u6301\u767e\u60a6\u6cfd®<\/sup>\u4e8e2020\u5e746\u6708\u5728\u4e2d\u56fd\u83b7\u5f97\u9644\u6761\u4ef6\u6279\u51c6<\/a>\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u7ebf\u6cbb\u7597\u7684CLL\u6216SLL\u6210\u4eba\u60a3\u8005\u3002<\/p>\n

\u5357\u4eac\u533b\u79d1\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\u6559\u6388\u3001\u672c\u8bd5\u9a8c\u7684\u4e3b\u8981\u7814\u7a76\u8005\u5f90\u536b\u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a\u201c\u767e\u60a6\u6cfd®<\/sup>\u5728\u989d\u5916\u768419\u4e2a\u6708\u968f\u8bbf\u65f6\u95f4\u4e2d\u53d6\u5f97\u7684\u6709\u6548\u6027\u548c\u8010\u53d7\u6027\u7ed3\u679c\u4f9d\u65e7\u4ee4\u4eba\u9f13\u821e\uff0c\u6211\u4eec\u5728\u66f4\u591a\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u66f4\u6df1\u5ea6\u7684\u7f13\u89e3\uff0c\u4e14\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u8b66\u793a\u3002\u67d3\u8272\u4f5311q\u7f3a\u5931\u3001\u67d3\u8272\u4f5317p\u7f3a\u5931\u548c\/\u6216TP53\u7a81\u53d8\u7684\u9ad8\u5371\u60a3\u8005\u4e5f\u80fd\u591f\u83b7\u5f97\u6df1\u5ea6\u548c\u6301\u4e45\u7684\u7f13\u89e3\uff0c\u800c\u5728\u4f34\u6709\u6dcb\u5df4\u7ec6\u80de\u589e\u591a\u7684\u90e8\u5206\u7f13\u89e3\uff08PR-L\uff09\u7684\u60a3\u8005\u4e2d\uff0c\u53d6\u5f97\u7684PFS\u4e0e\u8fbe\u5230CR\u6216PR\u60a3\u8005\u7684PFS\u76f8\u5f53\u3002\u201d<\/p>\n

\u572834\u4e2a\u6708\u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u91cc\uff0c\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\uff0c\u60a3\u8005\u63a5\u53d7\u767e\u60a6\u6cfd®<\/sup>\u6cbb\u7597\u540e\u7684\u75be\u75c5\u7f13\u89e3\u4e0d\u65ad\u589e\u52a0\u548c\u6df1\u5165\uff0c\u4e14\u5728\u6240\u6709\u4e9a\u7ec4\u4e2d\u4fdd\u6301\u4e00\u81f4\u7684\u8d8b\u52bf\u3002\u7ecfIRC\u8bc4\u4f30\u7684ORR\u4e3a87.9%\uff0c\u5176\u4e2d\u5305\u62ec6\u4f8b\u60a3\u8005\uff086.6%\uff09\u8fbe\u5230CR\u300163\u4f8b\u60a3\u8005\uff0869.2%\uff09\u8fbe\u5230\u90e8\u5206\u7f13\u89e3\uff08PR\uff09\uff0c11\u4f8b\u60a3\u8005\u53d6\u5f97\u4f34\u6709\u6dcb\u5df4\u7ec6\u80de\u589e\u591a\u7684\u90e8\u5206\u7f13\u89e3\uff08PR-L\uff1b12.1%\uff09\u3002<\/p>\n

\u968f\u7740\u968f\u8bbf\u65f6\u95f4\u7684\u5ef6\u957f\uff0c\u767e\u60a6\u6cfd®<\/sup>\u5728R\/R CLL\u60a3\u8005\u4e2d\u6301\u7eed\u4fdd\u6301\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u4e0e\u65e2\u5f80\u62a5\u544a\u7684\u6570\u636e\u76f8\u4f3c\uff0c\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u8b66\u793a\u3002\u6240\u670991\u4f8b\u60a3\u8005\uff08100%\uff09\u5747\u51fa\u73b0\u81f3\u5c111\u8d77\u4efb\u4f55\u7ea7\u522b\u7684TEAE\uff0c83.5%\u7684\u60a3\u8005\u51fa\u73b03\u7ea7\u53ca\u4ee5\u4e0a\u7684TEAE\uff0c15.4%\u7684\u60a3\u8005\u56e0TEAE\u7ec8\u6b62\u6cbb\u7597\uff0c6.6%\u7684\u60a3\u8005\u51fa\u73b0\u4e86\u81f4\u6b7b\u6027TEAE\u3002<\/p>\n

\u6b32\u4e86\u89e3\u66f4\u591a\u767e\u6d4e\u795e\u5dde\u7684\u7814\u53d1\u548c\u5728EHA2021\u524d\u540e\u7684\u6d3b\u52a8\uff0c\u8bf7\u8bbf\u95ee https:\/\/beigenemedical.eu<\/a>\u3002<\/b><\/p>\n

\u767e\u6d4e\u795e\u5ddeEHA2021\u6295\u8d44\u8005\u7535\u8bdd\u4f1a\u8bae\u548c\u7f51\u7edc\u76f4\u64ad\u4fe1\u606f <\/b><\/p>\n

\u767e\u6d4e\u795e\u5dde\u5c06\u4e8e\u5317\u4eac\u65f6\u95f46\u670812\u65e5\uff08\u5468\u516d\uff09\u96f6\u70b9\uff08\u5317\u7f8e\u4e1c\u90e8\u65f6\u95f46\u670811\u65e5\u4e2d\u534812\u70b9\uff09\u4e3e\u884c\u6295\u8d44\u4eba\u53ca\u5206\u6790\u5e08\u7535\u8bdd\u4f1a\u8bae\u548c\u7f51\u7edc\u76f4\u64ad\uff0c\u8ba8\u8bbaALPINE\u4e34\u5e8a\u8bd5\u9a8c\u5728\u671f\u4e2d\u5206\u6790\u4e2d\u83b7\u5f97\u7684\u7ed3\u679c\u3001\u5728EHA2021\u5c55\u793a\u7684\u5176\u4ed6\u6570\u636e\u53ca\u767e\u60a6\u6cfd®<\/sup>\u7684\u4e34\u5e8a\u9879\u76ee\u3002<\/p>\n

\u53ef\u901a\u8fc7\u767e\u6d4e\u795e\u5dde\u5b98\u65b9\u7f51\u7ad9\u6295\u8d44\u4eba\u7248\u5757\uff08http:\/\/ir.beigene.com<\/a>\u6216http:\/\/hkexir.beigene.com<\/a>\uff09\u6536\u770b\u672c\u6b21\u7535\u8bdd\u4f1a\u8bae\u7684\u5728\u7ebf\u76f4\u64ad\u3002\u4f1a\u8bae\u7ed3\u675f\u4e24\u5c0f\u65f6\u540e\uff0c\u53ef\u572890\u5929\u5185\u8bbf\u95ee\u5b98\u7f51\u6295\u8d44\u4eba\u7248\u5757\u89c2\u770b\u89c6\u9891\u56de\u653e\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u5728\u8fd13\u5e74\u7684\u957f\u671f\u968f\u8bbf\u4e2d\uff0c\u767e\u60a6\u6cfd®\u5728\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\u548c\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u60a3\u8005\u4e2d\u663e\u793a\u4e86\u957f\u671f\u4e34\u5e8a\u83b7\u76ca\u548c\u8010\u53d7\u6027 \u572834\u4e2a\u6708\u968f\u8bbf\u65f6\uff0c\u767e\u6cfd\u5b89®\u5728\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u4e2d\u83b7\u5f97\u4e86\u6df1\u5ea6\u548c\u6301\u4e45\u7684\u7f13\u89e3\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u8fbe\u523032\u4e2a\u6708\uff0c\u672a\u51fa\u73b0\u65b0\u7684\u5b89\u5168\u8b66\u793a \u516c\u53f8\u5c06\u4e8e\u5317\u4eac\u65f6\u95f46\u670812\u65e5\uff08\u5468\u516d\uff09\u96f6\u70b9\uff08\u7f8e\u4e1c\u65f6\u95f46\u670811\u65e5\u4e2d\u534812\u70b9\uff09\u53ec\u5f00\u7ebf\u4e0a\u6295\u8d44\u8005\u4f1a\u8bae \u7f8e\u56fd\u9ebb\u7701\u5251\u6865\u548c\u4e2d\u56fd\u5317\u4eac2021\u5e746\u670811\u65e5 \/\u7f8e\u901a\u793e\/ — \u767e\u6d4e\u795e\u5dde\uff08\u7eb3\u65af\u8fbe\u514b\u4ee3\u7801\uff1aBGNE\uff1b\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a06160\uff09\uff0c\u662f\u4e00\u5bb6\u5904\u4e8e\u5546\u4e1a\u9636\u6bb5\u7684\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5728\u4e16\u754c\u8303\u56f4\u5185\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u521b\u65b0\u836f\u7269\u3002\u516c\u53f8\u4eca\u65e5\u5ba3\u5e03\u57282021\u5e74\u7b2c26\u5c4a\u6b27\u6d32\u8840\u6db2\u5b66\u534f\u4f1a\uff08EHA2021\uff09\u7ebf\u4e0a\u5927\u4f1a\u4e0a\u516c\u5e03\u5176\u8840\u6db2\u5b66\u9879\u76ee\u4e2d\u7684\u4e09\u9879\u5173\u952e\u8bd5\u9a8c\u7684\u957f\u671f\u968f\u8bbf\u7ed3\u679c\uff0c\u5305\u62ec\u53e3\u5934\u62a5\u544a\u6297PD-1\u6297\u4f53\u836f\u7269\u767e\u6cfd\u5b89®\uff08\u66ff\u96f7\u5229\u73e0\u5355\u6297\uff09\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u6027\uff08R\/R\uff09\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08cHL\uff09\u76842\u671f\u8bd5\u9a8c\u6570\u636e\uff0c\u6d77\u62a5\u5c55\u793a\u4e24\u9879BTK\u6291\u5236\u5242\u767e\u60a6\u6cfd®\uff08\u6cfd\u5e03\u66ff\u5c3c\uff09\u7528\u4e8e\u6cbb\u7597R\/R\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u548cR\/R\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u6216\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08SLL\uff09\u76842\u671f\u8bd5\u9a8c\u6570\u636e\u3002 \u767e\u6d4e\u795e\u5dde\u8840\u6db2\u5b66\u9996\u5e2d\u533b\u5b66\u5b98\u9ec4\u851a\u5a1f\u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a\u201c\u6211\u4eec\u975e\u5e38\u9ad8\u5174\u770b\u5230\u767e\u6cfd\u5b89®\u548c\u767e\u60a6\u6cfd®\u5728\u8fd9\u4e9b\u5173\u952e\u6027\u8bd5\u9a8c\u4e2d\u4e3a\u60a3\u8005\u5e26\u6765\u957f\u671f\u4e34\u5e8a\u83b7\u76ca\uff0c\u8fd9\u4e3a\u4e24\u6b3e\u4ea7\u54c1\u5728\u4e2d\u56fd\u83b7\u5f97\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u6027cHL\u548cCLL\u6216SLL\u60a3\u8005\uff0c\u4ee5\u53ca\u767e\u60a6\u6cfd®\u5728\u7f8e\u56fd\u548c\u4e2d\u56fd\u83b7\u5f97\u6279\u51c6\u7528\u4e8eMCL\u60a3\u8005\u63d0\u4f9b\u4e86\u652f\u6301\u3002\u7814\u7a76\u663e\u793a\uff0c\u968f\u7740\u6cbb\u7597\u65f6\u95f4\u5ef6\u957f\uff0c\u767e\u6cfd\u5b89®\u8fbe\u5230\u4e86\u66f4\u9ad8\u7684\u5b8c\u5168\u7f13\u89e3\u7387\uff0c\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u8b66\u793a\uff0c\u800c\u6df1\u5ea6\u7f13\u89e3\u4e5f\u8f6c\u6362\u6210\u4e86\u4e0d\u4fd7\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u7ed3\u679c\u3002\u800c\u5728\u4e24\u9879\u767e\u60a6\u6cfd®\u7684\u8bd5\u9a8c\u4e2d\uff0c\u6211\u4eec\u7684\u9ad8\u9009\u62e9\u6027\u65b0\u4e00\u4ee3BTK\u6291\u5236\u5242\u6301\u7eed\u5e26\u6765\u4e86\u6df1\u5ea6\u7684\u75be\u75c5\u7f13\u89e3\uff0c\u5e76\u5728\u8fd9\u4e9b\u60a3\u8005\u4e2d\u4ea7\u751f\u4e86\u826f\u597d\u7684\u8010\u53d7\u6027\u3002\u968f\u7740\u767e\u6d4e\u795e\u5dde\u7ee7\u7eed\u5728\u5168\u7403\u5e03\u5c40\uff0c\u6211\u4eec\u5c06\u4e00\u5982\u65e2\u5f80\u5730\u52aa\u529b\u5c06\u8fd9\u4e9b\u91cd\u8981\u7597\u6cd5\u5e26\u7ed9\u66f4\u591a\u6709\u9700\u8981\u7684\u60a3\u8005\u3002\u201d \u767e\u6cfd\u5b89®\u6cbb\u7597R\/R cHL\u7684\u957f\u671f\u968f\u8bbf\u7ed3\u679c \u53e3\u5934\u62a5\u544a\uff1b\u6458\u8981\u4ee3\u7801\uff1aS207 \u8fd9\u9879\u5355\u81c2\u3001\u591a\u4e2d\u5fc3\u3001\u5173\u952e\u60272\u671f\u8bd5\u9a8c\uff08NCT03209973\uff09\u768434\u4e2a\u6708\u968f\u8bbf\u7ed3\u679c\u8868\u660e\uff0c\u767e\u6cfd\u5b89®\u7528\u4e8eR\/R cHL\u60a3\u8005\u7684\u6cbb\u7597\u5177\u6709\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d\u3002\u8fd9\u9879\u5173\u952e\u60272\u671f\u8bd5\u9a8c\u7684\u7ed3\u679c\u652f\u6301\u767e\u6cfd\u5b89®\u4e8e2019\u5e7412\u6708\u5728\u4e2d\u56fd\u83b7\u5f97\u9644\u6761\u4ef6\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u81f3\u5c11\u7ecf\u8fc7\u4e8c\u7ebf\u7cfb\u7edf\u5316\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027cHL\u60a3\u8005\u3002  \u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662\u6dcb\u5df4\u7624\u79d1\u4e3b\u6cbb\u533b\u5e08\u3001\u526f\u4e3b\u4efb\u533b\u5e08\u3001\u8bd5\u9a8c\u4e3b\u8981\u7814\u7a76\u8005\u5b8b\u7389\u7434\u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a\u201c\u5c3d\u7ba1\u65e2\u5f80\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5728R\/R cHL\u6cbb\u7597\u65b9\u9762\u53d6\u5f97\u4e86\u8fdb\u5c55\uff0c\u4f46\u53ea\u6709\u5c11\u6570\u60a3\u8005\u80fd\u591f\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\u3002\u598234\u4e2a\u6708\u968f\u8bbf\u7ed3\u679c\u6240\u793a\uff0c\u65e0\u8bba\u4e9a\u7ec4\u7279\u5f81\u5982\u4f55\uff0c\u767e\u6cfd\u5b89®\u5728\u8fd9\u4e9b\u60a3\u8005\u4e2d\u5747\u5e26\u6765\u4e86\u6df1\u5ea6\u3001\u6301\u4e45\u548c\u6301\u7eed\u7684\u7f13\u89e3\uff0c\u8fd170%\u7684\u60a3\u8005\u53d6\u5f97\u4e86\u5b8c\u5168\u7f13\u89e3\u3002\u6211\u4eec\u76f8\u4fe1\u8fd9\u4e00NMPA\u6279\u51c6\u7684\u514d\u75ab\u6cbb\u7597\u836f\u7269\u80fd\u591f\u4e3a\u4e2d\u56fd\u7684R\/R cHL\u60a3\u8005\u5e26\u6765\u6301\u7eed\u7684\u4e34\u5e8a\u83b7\u76ca\u3002\u201d \u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a34\u4e2a\u6708\u65f6\uff0c\u5728\u6240\u6709\u60a3\u8005\u4e9a\u7ec4\u7684R\/R cHL\u60a3\u8005\u4e2d\uff0c\u767e\u6cfd\u5b89®\u5747\u8868\u73b0\u51fa\u6df1\u5ea6\u548c\u6301\u4e45\u7684\u7f13\u89e3\u3002\u7ecfIRC\u8bc4\u4f30\u7684\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a87.1%\uff0895%CI\uff1a77.0\uff0c93.9\uff09\uff0c\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\u7387\u4e3a67.1%\uff0895% CI\uff1a54.9, 77.9\uff09\u3002\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u968f\u8bbf\u65f6\u95f4\u4e3a31.5\u4e2a\u6708\uff0895% CI\uff1a16.53\uff0c\u4e0d\u53ef\u4f30\u8ba1[NE]\uff09\uff0c\u9884\u4f30\u768424\u4e2a\u6708\u548c36\u4e2a\u6708\u65e0\u8fdb\u5c55\u751f\u5b58\u7387\u5206\u522b\u4e3a55.4%\uff0895% CI\uff1a42.2\uff0c66.8\uff09\u548c40.8%\uff0895% CI: 25.2\uff0c55.8\uff09 \u3002\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08OS\uff09\u672a\u8fbe\u5230\uff0c24\u4e2a\u6708\u548c36\u4e2a\u6708\u7684OS\u7387\u4e3a93.9%\uff0895% CI\uff1a84.5\uff0c97.7\uff09\u548c84.8%\uff0895% CI: 70.5\uff0c92.6\uff09\u3002 \u5728\u957f\u671f\u6cbb\u7597\u4e0b\uff0c\u767e\u6cfd\u5b89®\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d\uff0c\u5927\u591a\u6570\u4e0d\u826f\u4e8b\u4ef6\u4e3a1\u81f32\u7ea7\uff0c\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u8b66\u793a\u3002\u4efb\u4f55\u7ea7\u522b\u6cbb\u7597\u4e2d\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TEAE\uff09\u572897.1%\u7684\u60a3\u8005\u4e2d\u51fa\u73b0\uff0c3\u7ea7\u53ca\u4ee5\u4e0aTEAE\u572841.1%\u7684\u60a3\u8005\u4e2d\u51fa\u73b0\uff0c8.6%\u7684\u60a3\u8005\u56e0TEAE\u800c\u7ec8\u6b62\u6cbb\u7597\u3002 \u767e\u60a6\u6cfd®\u6cbb\u7597R\/R MCL\u7684\u957f\u671f\u968f\u8bbf\u7ed3\u679c \u6d77\u62a5\u62a5\u544a\uff1b\u6458\u8981\u4ee3\u7801\uff1aEP789 \u5355\u81c2\u3001\u5f00\u653e\u6027\u3001\u591a\u4e2d\u5fc3\u5173\u952e\u60272\u671f\u8bd5\u9a8c\uff08NCT03206970\uff09\u768435\u4e2a\u6708\u968f\u8bbf\u7ed3\u679c\u663e\u793a\u4e86\u767e\u60a6\u6cfd®\u5bf9R\/R MCL\u60a3\u8005\u7684\u957f\u671f\u83b7\u76ca\u548c\u8010\u53d7\u6027\u3002\u8fd9\u9879\u5173\u952e\u60272\u671f\u8bd5\u9a8c\u7684\u7ed3\u679c\u5305\u542b\u652f\u6301\u767e\u60a6\u6cfd®2019\u5e7411\u6708\u5728\u7f8e\u56fd\u83b7\u5f97\u52a0\u901f\u6279\u51c6\u548c2020\u5e746\u6708\u5728\u4e2d\u56fd\u83b7\u5f97\u9644\u6761\u4ef6\u6279\u51c6\u7528\u4e8e\u8be5\u9002\u5e94\u75c7\u7684\u6570\u636e\u3002 \u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662\u6dcb\u5df4\u7624\u79d1\u4e3b\u6cbb\u533b\u5e08\u3001\u526f\u4e3b\u4efb\u533b\u5e08\u3001\u8bd5\u9a8c\u4e3b\u8981\u7814\u7a76\u8005\u5b8b\u7389\u7434\u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a\u201c\u7ecf\u8fc7\u8fd13\u5e74\u7684\u60a3\u8005\u968f\u8bbf\uff0c\u767e\u60a6\u6cfd®\u5728R\/R MCL\u60a3\u8005\u4e2d\u4fdd\u6301\u4e86\u8f83\u9ad8\u7684\u7f13\u89e3\u7387\uff0c\u5e76\u4e14\u968f\u7740\u6cbb\u7597\u65f6\u95f4\u7684\u5ef6\u957f\uff0c\u5b89\u5168\u6027\u6307\u6807\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u4fdd\u6301\u4e86\u7a33\u5b9a\u3002\u6211\u4eec\u5e0c\u671b\u8fd9\u4e9b\u4ee4\u4eba\u9f13\u821e\u7684\u7ed3\u679c\uff0c\u80fd\u8fdb\u4e00\u6b65\u786e\u7acb\u8fd9\u4e00\u9ad8\u9009\u62e9\u6027BTK\u6291\u5236\u5242\u6210\u4e3a\u5728\u5df2\u6279\u51c6\u5730\u533a\u4e2d\u5bf9R\/R MCL\u60a3\u8005\u7684\u9996\u9009\u6cbb\u7597\u65b9\u6848\u3002\u201d \u5728\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a35.3\u4e2a\u6708\u3001\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a27.6\u4e2a\u6708\u65f6\uff0c\u767e\u60a6\u6cfd®\u5728R\/R MCL\u60a3\u8005\u4e2d\u8868\u73b0\u51fa\u9ad8\u6548\u3001\u6df1\u5ea6\u548c\u6301\u7eed\u7684\u6709\u6548\u6027\uff0c\u4e14\u5404\u4e9a\u7ec4\u60a3\u8005\u53d6\u5f97\u7684\u7f13\u89e3\u7387\u5927\u4f53\u4e00\u81f4\u3002\u7ecf\u7814\u7a76\u8005\u8bc4\u4f30\u7684ORR\u4e3a83.7%\uff0895% CI\uff1a74.2\uff0c90.8\uff09\uff0c\u5305\u62ec67\u4f8b\u60a3\u8005\uff0877.9%\uff09\u8fbe\u5230CR\u3002\u4e2d\u4f4dPFS\u4e3a33.0\u4e2a\u6708\uff0895% CI\uff1a19.4\uff0cNE\uff09\uff0c\u9884\u4f30\u768436\u4e2a\u6708\u65e0\u8fdb\u5c55\u751f\u5b58\u7387\u4e3a47.6%\uff0895% CI\uff1a36.2\uff0c58.1\uff09\u3002 \u968f\u7740\u957f\u671f\u968f\u8bbf\uff0c\u767e\u60a6\u6cfd®\u7684\u5b89\u5168\u6027\u6307\u6807\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u4fdd\u6301\u4e86\u7a33\u5b9a\u3002\u5927\u90e8\u5206\u4e0d\u826f\u4e8b\u4ef6\u51fa\u73b0\u5728\u65e9\u671f\u6cbb\u7597\u9636\u6bb5\uff0c\u672a\u56e0TEAE\u51fa\u73b0\u989d\u5916\u7684\u5242\u91cf\u964d\u4f4e\u3001\u6cbb\u7597\u7ec8\u6b62\u6216\u6b7b\u4ea1\u30023\u7ea7\u53ca\u4ee5\u4e0aTEAE\u51fa\u73b0\u572850.0%\u7684\u60a3\u8005\u4e2d\u3002 \u767e\u60a6\u6cfd®\u6cbb\u7597R\/R CLL\u6216SLL\u7684\u957f\u671f\u968f\u8bbf\u7ed3\u679c \u6d77\u62a5\u62a5\u544a\uff1b\u6458\u8981\u4ee3\u7801\uff1aEP639 \u57fa\u4e8e\u5355\u81c2\u3001\u5f00\u653e\u6027\u3001\u591a\u4e2d\u5fc3\u5173\u952e\u60272\u671f\u8bd5\u9a8c\uff08NCT03206918\uff09\u768434\u4e2a\u6708\u968f\u8bbf\u7ed3\u679c\uff0c\u65e0\u8bba\u4e9a\u7ec4\u7279\u5f81\u5982\u4f55\uff0c\u767e\u60a6\u6cfd®\u4ecd\u5728R\/R CLL\u60a3\u8005\u4e2d\u8868\u73b0\u51fa\u6df1\u5ea6\u548c\u6301\u4e45\u7684\u7f13\u89e3\uff0c\u4e14\u8010\u53d7\u6027\u826f\u597d\uff0c\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u8b66\u793a\u3002\u8fd9\u9879\u5173\u952e\u60272\u671f\u8bd5\u9a8c\u7684\u7ed3\u679c\u652f\u6301\u767e\u60a6\u6cfd®\u4e8e2020\u5e746\u6708\u5728\u4e2d\u56fd\u83b7\u5f97\u9644\u6761\u4ef6\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u7ebf\u6cbb\u7597\u7684CLL\u6216SLL\u6210\u4eba\u60a3\u8005\u3002 \u5357\u4eac\u533b\u79d1\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\u6559\u6388\u3001\u672c\u8bd5\u9a8c\u7684\u4e3b\u8981\u7814\u7a76\u8005\u5f90\u536b\u533b\u5b66\u535a\u58eb\u8868\u793a\uff1a\u201c\u767e\u60a6\u6cfd®\u5728\u989d\u5916\u768419\u4e2a\u6708\u968f\u8bbf\u65f6\u95f4\u4e2d\u53d6\u5f97\u7684\u6709\u6548\u6027\u548c\u8010\u53d7\u6027\u7ed3\u679c\u4f9d\u65e7\u4ee4\u4eba\u9f13\u821e\uff0c\u6211\u4eec\u5728\u66f4\u591a\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u66f4\u6df1\u5ea6\u7684\u7f13\u89e3\uff0c\u4e14\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u8b66\u793a\u3002\u67d3\u8272\u4f5311q\u7f3a\u5931\u3001\u67d3\u8272\u4f5317p\u7f3a\u5931\u548c\/\u6216TP53\u7a81\u53d8\u7684\u9ad8\u5371\u60a3\u8005\u4e5f\u80fd\u591f\u83b7\u5f97\u6df1\u5ea6\u548c\u6301\u4e45\u7684\u7f13\u89e3\uff0c\u800c\u5728\u4f34\u6709\u6dcb\u5df4\u7ec6\u80de\u589e\u591a\u7684\u90e8\u5206\u7f13\u89e3\uff08PR-L\uff09\u7684\u60a3\u8005\u4e2d\uff0c\u53d6\u5f97\u7684PFS\u4e0e\u8fbe\u5230CR\u6216PR\u60a3\u8005\u7684PFS\u76f8\u5f53\u3002\u201d \u572834\u4e2a\u6708\u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u91cc\uff0c\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\uff0c\u60a3\u8005\u63a5\u53d7\u767e\u60a6\u6cfd®\u6cbb\u7597\u540e\u7684\u75be\u75c5\u7f13\u89e3\u4e0d\u65ad\u589e\u52a0\u548c\u6df1\u5165\uff0c\u4e14\u5728\u6240\u6709\u4e9a\u7ec4\u4e2d\u4fdd\u6301\u4e00\u81f4\u7684\u8d8b\u52bf\u3002\u7ecfIRC\u8bc4\u4f30\u7684ORR\u4e3a87.9%\uff0c\u5176\u4e2d\u5305\u62ec6\u4f8b\u60a3\u8005\uff086.6%\uff09\u8fbe\u5230CR\u300163\u4f8b\u60a3\u8005\uff0869.2%\uff09\u8fbe\u5230\u90e8\u5206\u7f13\u89e3\uff08PR\uff09\uff0c11\u4f8b\u60a3\u8005\u53d6\u5f97\u4f34\u6709\u6dcb\u5df4\u7ec6\u80de\u589e\u591a\u7684\u90e8\u5206\u7f13\u89e3\uff08PR-L\uff1b12.1%\uff09\u3002 \u968f\u7740\u968f\u8bbf\u65f6\u95f4\u7684\u5ef6\u957f\uff0c\u767e\u60a6\u6cfd®\u5728R\/R CLL\u60a3\u8005\u4e2d\u6301\u7eed\u4fdd\u6301\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u4e0e\u65e2\u5f80\u62a5\u544a\u7684\u6570\u636e\u76f8\u4f3c\uff0c\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u8b66\u793a\u3002\u6240\u670991\u4f8b\u60a3\u8005\uff08100%\uff09\u5747\u51fa\u73b0\u81f3\u5c111\u8d77\u4efb\u4f55\u7ea7\u522b\u7684TEAE\uff0c83.5%\u7684\u60a3\u8005\u51fa\u73b03\u7ea7\u53ca\u4ee5\u4e0a\u7684TEAE\uff0c15.4%\u7684\u60a3\u8005\u56e0TEAE\u7ec8\u6b62\u6cbb\u7597\uff0c6.6%\u7684\u60a3\u8005\u51fa\u73b0\u4e86\u81f4\u6b7b\u6027TEAE\u3002 \u6b32\u4e86\u89e3\u66f4\u591a\u767e\u6d4e\u795e\u5dde\u7684\u7814\u53d1\u548c\u5728EHA2021\u524d\u540e\u7684\u6d3b\u52a8\uff0c\u8bf7\u8bbf\u95ee https:\/\/beigenemedical.eu\u3002 \u767e\u6d4e\u795e\u5ddeEHA2021\u6295\u8d44\u8005\u7535\u8bdd\u4f1a\u8bae\u548c\u7f51\u7edc\u76f4\u64ad\u4fe1\u606f  \u767e\u6d4e\u795e\u5dde\u5c06\u4e8e\u5317\u4eac\u65f6\u95f46\u670812\u65e5\uff08\u5468\u516d\uff09\u96f6\u70b9\uff08\u5317\u7f8e\u4e1c\u90e8\u65f6\u95f46\u670811\u65e5\u4e2d\u534812\u70b9\uff09\u4e3e\u884c\u6295\u8d44\u4eba\u53ca\u5206\u6790\u5e08\u7535\u8bdd\u4f1a\u8bae\u548c\u7f51\u7edc\u76f4\u64ad\uff0c\u8ba8\u8bbaALPINE\u4e34\u5e8a\u8bd5\u9a8c\u5728\u671f\u4e2d\u5206\u6790\u4e2d\u83b7\u5f97\u7684\u7ed3\u679c\u3001\u5728EHA2021\u5c55\u793a\u7684\u5176\u4ed6\u6570\u636e\u53ca\u767e\u60a6\u6cfd®\u7684\u4e34\u5e8a\u9879\u76ee\u3002 \u53ef\u901a\u8fc7\u767e\u6d4e\u795e\u5dde\u5b98\u65b9\u7f51\u7ad9\u6295\u8d44\u4eba\u7248\u5757\uff08http:\/\/ir.beigene.com\u6216http:\/\/hkexir.beigene.com\uff09\u6536\u770b\u672c\u6b21\u7535\u8bdd\u4f1a\u8bae\u7684\u5728\u7ebf\u76f4\u64ad\u3002\u4f1a\u8bae\u7ed3\u675f\u4e24\u5c0f\u65f6\u540e\uff0c\u53ef\u572890\u5929\u5185\u8bbf\u95ee\u5b98\u7f51\u6295\u8d44\u4eba\u7248\u5757\u89c2\u770b\u89c6\u9891\u56de\u653e\u3002… Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":8278,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-33957","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/33957","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=33957"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/33957\/revisions"}],"predecessor-version":[{"id":33958,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/33957\/revisions\/33958"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/8278"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=33957"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=33957"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=33957"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}