{"id":33939,"date":"2021-06-11T15:58:00","date_gmt":"2021-06-11T08:58:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021061115580033939"},"modified":"2021-06-11T21:49:03","modified_gmt":"2021-06-11T13:49:03","slug":"%e5%85%8d%e7%96%ab%e5%8f%8c%e5%ad%90%e6%98%9f%e8%8e%b7%e5%9b%bd%e5%ae%b6%e8%8d%af%e7%9b%91%e5%b1%80%e6%89%b9%e5%87%86%e7%94%a8%e4%ba%8e%e6%81%b6%e6%80%a7%e8%83%b8%e8%86%9c%e9%97%b4","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021061115580033939","title":{"rendered":"\u514d\u75ab\u201c\u53cc\u5b50\u661f\u201d\u83b7\u56fd\u5bb6\u836f\u76d1\u5c40\u6279\u51c6\u7528\u4e8e\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u4e00\u7ebf\u6cbb\u7597"},"content":{"rendered":"<p><p><span class=\"xn-subheadline\">\u6b27\u72c4\u6c83\u00ae\u8054\u5408\u9038\u6c83\u00ae\u6210\u4e3a\u56fd\u5185\u9996\u4e2a\u4e14\u76ee\u524d\u552f\u4e00\u83b7\u6279\u53cc\u514d\u75ab\u7597\u6cd5<\/span><\/p>\n<ul type=\"disc\">\n<li><i>\u8be5\u6279\u51c6\u57fa\u4e8e<\/i><i>CheckMate-743\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\uff0c\u7814\u7a76\u7ed3\u679c\u8bc1\u5b9e\uff0c\u63a5\u53d7\u6b27\u72c4\u6c83\u8054\u5408\u9038\u6c83\u6cbb\u7597\u7684\u60a3\u8005<b>\u603b\u751f\u5b58\u671f\u663e\u8457\u4f18\u4e8e\u6807\u51c6\u5316\u7597<\/b>\uff1b\u8fd9\u662f\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u5728\u8be5\u60a3\u8005\u4eba\u7fa4\u4e2d<b>\u9996\u4e2a\u83b7\u5f97\u9633\u6027\u7ed3\u679c\u7684III\u671f\u4e34\u5e8a\u7814\u7a76<\/b><\/i><b>&nbsp; <\/b><\/li>\n<li><i>\u6b27\u72c4\u6c83\u8054\u5408\u9038\u6c83\u6210\u4e3a<\/i><i><b>15\u5e74\u6765\u9996\u4e2a<\/b><\/i><i>\u4e3a\u80f8\u819c\u95f4\u76ae\u7624\u60a3\u8005\u5e26\u6765\u751f\u5b58\u83b7\u76ca\u7684<b>\u65b0\u7cfb\u7edf\u6027\u7597\u6cd5<\/b><\/i><i>\uff0c\u6253\u7834\u591a\u5e74\u65e0\u65b0\u836f\u50f5\u5c40<\/i>&nbsp; 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(<span id=\"spanHghltd786\">\u98ce\u9669\u6bd4[HR]<\/span>: 0.74 [96.6% \u7f6e\u4fe1\u533a\u95f4]: 0.60, 0.91; p=0.002)\u3002\u6b27\u72c4\u6c83\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\u7ec4\u60a3\u80052\u5e74\u751f\u5b58\u7387\u4e3a41%\uff0c\u5316\u7597\u7ec4\u4e3a27%\u3002<\/p>\n<p>\u7ec4\u7ec7\u5b66\u7c7b\u578b\u662f\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u516c\u8ba4\u7684\u9884\u540e\u56e0\u7d20\uff0c\u975e\u4e0a\u76ae\u6837\u7ec4\u7ec7\u7c7b\u578b\u901a\u5e38\u9884\u540e\u66f4\u5dee\u3002\u5728CheckMate-743\u7814\u7a76\u4e2d\uff0c\u60a3\u8005\u6309\u7ec4\u7ec7\u5b66\u7c7b\u578b\u968f\u673a\u5206\u5c42\uff0c\u4f7f\u7528\u6b27\u72c4\u6c83\u8054\u5408\u9038\u6c83\u6cbb\u7597\u7684\u975e\u4e0a\u76ae\u6837\u548c\u4e0a\u76ae\u6837\u80f8\u819c\u95f4\u76ae\u7624\u60a3\u8005\u7684\u751f\u5b58\u671f\u5747\u6709\u6539\u5584\uff0c\u5728\u975e\u4e0a\u76ae\u6837\u7ec4\u7ec7\u7c7b\u578b\u60a3\u8005\u4e9a\u7ec4\u4e2d\u89c2\u5bdf\u5230\u7684\u4f18\u52bf\u66f4\u5927\u3002\u5728\u53cc\u514d\u75ab\u8054\u5408\u6cbb\u7597\u7ec4\u4e2d\uff0c\u975e\u4e0a\u76ae\u6837\u7ec4\u7ec7\u7c7b\u578b\u60a3\u8005\u7684\u4e2d\u4f4dOS\u4e3a&nbsp;18.1\u4e2a\u6708\uff0c\u800c\u5316\u7597\u7ec4\u4e2d\u5bf9\u5e94\u60a3\u8005\u7684\u4e2d\u4f4dOS\u4ec5\u4e3a8.8\u4e2a\u6708 <span id=\"spanHghlt9dfa\">(\u98ce\u9669\u6bd4[HR]:<\/span> 0.46 [95% \u7f6e\u4fe1\u533a\u95f4]: 0.31, 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id=\"spanHghltc93f\">\u201d<\/span><\/p>\n<p>\u5728\u6700\u65b0\u53d1\u5e03\u7684\u300a\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a(CSCO)\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u4e34\u5e8a\u5e94\u7528\u6307\u5357(2021\u5e74\u7248)\u300b<sup>[3]<\/sup>\u4e2d\uff0c\u6b27\u72c4\u6c83\u8054\u5408\u9038\u6c83\u4e00\u7ebf\u6cbb\u7597\u975e\u4e0a\u76ae\u6837\u548c\u4e0a\u76ae\u6837\u80f8\u819c\u95f4\u76ae\u7624\u6210\u4e3a<b>\u552f\u4e00\u83b7\u5f97<\/b><b>I\u7ea7\uff081\u7c7b\u8bc1\u636e\uff09\u548cII\u7ea7\u63a8\u8350\uff082A\u7c7b\u8bc1\u636e\uff09\u7684\u6cbb\u7597\u65b9\u6848<\/b>\u3002<\/p>\n<p>\u6b27\u72c4\u6c83\u8054\u5408\u9038\u6c83\u662f\u4e24\u79cd\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u72ec\u7279\u7ec4\u5408\uff0c\u5206\u522b\u9776\u5411\u4e24\u4e2a\u4e0d\u540c\u7684\u68c0\u67e5\u70b9\uff08PD-1\u548cCTLA-4\uff09\u4ee5\u5e2e\u52a9\u7834\u574f\u80bf\u7624\u7ec6\u80de\uff0c\u4e24\u8005\u5177\u6709\u6f5c\u5728\u7684\u534f\u540c\u4f5c\u7528\u673a\u5236\uff1a\u9038\u6c83\u80fd\u4fc3\u8fdbT\u7ec6\u80de\u7684\u6fc0\u6d3b\u548c\u589e\u6b96\uff0c\u800c\u6b27\u72c4\u6c83\u5e2e\u52a9\u73b0\u6709\u7684T\u7ec6\u80de\u8bc6\u522b\u80bf\u7624\u7ec6\u80de\u3002\u9038\u6c83\u6fc0\u6d3b\u7684\u90e8\u5206T\u7ec6\u80de\u8fd8\u53ef\u4ee5\u5206\u5316\u4e3a\u8bb0\u5fc6T\u7ec6\u80de\uff0c\u5e2e\u52a9\u5b9e\u73b0\u957f\u671f\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n<p><b>\u5e7f\u4e1c\u7701\u4eba\u6c11\u533b\u9662\u7ec8\u8eab\u4e3b\u4efb\u3001\u5e7f\u4e1c\u7701\u80ba\u764c\u7814\u7a76\u6240\uff08<\/b><b>GLCI\uff09\u540d\u8a89\u6240\u957f\u5434\u4e00\u9f99\u6559\u6388<\/b>\u8868\u793a\uff1a<span id=\"spanHghltadcf\">\u201c<\/span>\u6b27\u72c4\u6c83\u8054\u5408\u9038\u6c83\u901a\u8fc7\u6f5c\u5728\u7684\u534f\u540c\u4f5c\u7528\u4e3a\u665a\u671f\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u60a3\u8005\u5e26\u6765<b>\u663e\u8457\u4e14\u6301\u4e45\u7684\u603b\u751f\u5b58\u83b7\u76ca<\/b>\uff0c\u4f7f\u5f97\u201c\u53bb\u5316\u7597\u201d\u6210\u4e3a\u53ef\u80fd\u3002\u5728CheckMate-743\u7814\u7a76\u4e2d\uff0c\u6b27\u72c4\u6c83\uff083mg\/kg\uff0c\u6bcf2\u5468\u4e00\u6b21\uff09\u8054\u5408\u9038\u6c83\uff081mg\/kg\uff0c\u6bcf6\u5468\u4e00\u6b21\uff09\u4e00\u7ebf\u6cbb\u7597\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u7684\u5b89\u5168\u6027\u7279\u5f81\u4e0e\u8be5\u8054\u5408\u6cbb\u7597\u6b64\u524d\u5728\u5176\u4ed6\u7624\u79cd\u7814\u7a76\u4e2d\u7684\u5b89\u5168\u6027\u4e00\u81f4\uff0c\u5305\u62ec\u80ba\u764c\u4e00\u7ebf\u53cc\u514d\u75ab\u6cbb\u7597\u5728\u5185\uff0c\u5b9e\u73b0\u4e86\u7597\u6548\u548c\u5b89\u5168\u7684\u5e73\u8861\uff0c\u9884\u793a\u7740\u53cc\u514d\u75ab\u8054\u5408\u6cbb\u7597\u5728\u672a\u6765\u5c06\u6709\u673a\u4f1a\u5728\u4e0d\u540c\u7624\u79cd\u4e2d\u4e3a\u4e2d\u56fd\u60a3\u8005\u5e26\u6765\u83b7\u76ca\u3002<span id=\"spanHghltc93f\">\u201d<\/span><\/p>\n<p><b>\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u4e2d\u56fd\u5927\u9646\u53ca\u9999\u6e2f\u5730\u533a\u603b\u7ecf\u7406\u9648\u601d\u6e0a\u5973\u58eb\u8868\u793a<\/b>\uff1a\u201c\u52a0\u901f\u5168\u7403\u521b\u65b0\u836f\u7269\u843d\u5730\u4e2d\u56fd\u662f\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u77e2\u5fd7\u4e0d\u6e1d\u7684\u627f\u8bfa\u3002\u7ee7\u5728\u56fd\u5185\u4e0a\u5e02\u9996\u4e2aPD-1\u6291\u5236\u5242\u2018\u6b27\u72c4\u6c83\u2019\u540e\uff0c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u518d\u6b21\u5c06\u5168\u7403\u9996\u4e2aCTLA-4\u6291\u5236\u5242\u2018\u9038\u6c83\u2019\u5e26\u5165\u4e2d\u56fd\uff0c\u5e76\u4e0d\u65ad\u901a\u8fc7\u79d1\u5b66\u6539\u53d8\u60a3\u8005\u7684\u751f\u547d\u3002\u672a\u6765\uff0c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u5c06\u7ee7\u7eed\u63a2\u7d22\u514d\u75ab\u80bf\u7624\u6cbb\u7597\u5728\u4e0d\u540c\u7624\u79cd\u4e2d\u7684\u5e94\u7528\uff0c\u5305\u62ec\u514d\u75ab\u8054\u5408\u6cbb\u7597\u5728\u5185\uff0c\u4ee5\u671f\u4e3a\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u6211\u4eec\u5c06\u4e0d\u65ad\u63a2\u7d22\u4e0e\u4e2d\u56fd\u653f\u5e9c\u3001\u652f\u4ed8\u65b9\u53ca\u7b2c\u4e09\u65b9\u673a\u6784\u7684\u5408\u4f5c\uff0c\u901a\u8fc7\u521b\u65b0\u7684\u51c6\u5165\u6a21\u5f0f\u4ee5\u53ca\u591a\u5143\u5316\u7684\u4e3e\u63aa\uff0c\u5171\u540c\u63d0\u9ad8\u53cc\u514d\u75ab\u6cbb\u7597\u5728\u56fd\u5185\u7684\u53ef\u53ca\u6027\u3002\u201d<\/p>\n<p>2015\u5e7410\u6708\uff0c\u6b27\u72c4\u6c83\u8054\u5408\u9038\u6c83\u6210\u4e3a\u5168\u7403\u9996\u4e2a\u83b7\u5f97\u76d1\u7ba1\u673a\u6784\u6279\u51c6\u7684\u514d\u75ab\u80bf\u7624\u8054\u5408\u6cbb\u7597\uff0c\u76ee\u524d\u5df2\u5728\u5168\u7403\u8d85\u8fc750\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u83b7\u62796\u4e2a\u7624\u79cd\uff0c\u6db5\u76d6<b>\u80ba\u764c\u3001\u80f8\u819c\u95f4\u76ae\u7624\u3001\u9ed1\u8272\u7d20\u7624\u3001\u80be\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u809d\u764c<\/b>\u3002<\/p>\n<p><b><u>\u5173\u4e8e<\/u><\/b><b><u>CheckMate-743<\/u><\/b><\/p>\n<p>CheckMate -743\u662f\u4e00\u9879\u5f00\u653e\u6807\u7b7e\u3001\u591a\u4e2d\u5fc3\u3001\u968f\u673aIII\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\u5bf9\u6bd4\u6807\u51c6\u5316\u7597\uff08\u57f9\u7f8e\u66f2\u585e\u8054\u5408\u987a\u94c2\u6216\u5361\u94c2\uff09\u7528\u4e8e\u65e2\u5f80\u672a\u7ecf\u6cbb\u7597\u7684\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\uff08MPM\uff09\u60a3\u8005\uff08n=605\uff09\u7684\u6cbb\u7597\u6548\u679c\u3002\u8be5\u7814\u7a76\u6392\u9664\u4e86\u95f4\u8d28\u6027\u80ba\u90e8\u75be\u75c5\u3001\u6d3b\u52a8\u6027\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u3001\u4e34\u5e8a\u9700\u8981\u63a5\u53d7\u7cfb\u7edf\u6027\u514d\u75ab\u6291\u5236\u3001\u4ee5\u53ca\u51fa\u73b0\u6d3b\u52a8\u6027\u8111\u8f6c\u79fb\u7684\u60a3\u8005\u3002\u5728\u8be5\u7814\u7a76\u4e2d\uff0c303\u4f8b\u60a3\u8005\u968f\u673a\u63a5\u53d7\u6b27\u72c4\u6c83\uff083mg\/kg\uff0c\u6bcf2\u5468\u4e00\u6b21\uff09\u8054\u5408\u9038\u6c83\uff081mg\/kg\uff0c\u6bcf6\u5468\u4e00\u6b21\uff09\u6cbb\u7597\uff0c\u6301\u7eed\u6cbb\u7597\u76f4\u81f3\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\uff0c\u6700\u957f\u6cbb\u7597\u65f6\u95f4\u4e3a24\u4e2a\u6708\u3002302\u4f8b\u60a3\u8005\u968f\u673a\u63a5\u53d7\u987a\u94c2\uff0875mg\/m2\uff09\u6216\u5361\u94c2\uff08AUC 5\uff09\u8054\u5408\u57f9\u7f8e\u66f2\u585e\uff08500 mg\/m2\uff09\u6cbb\u7597\uff0c\u6bcf3\u5468\u4e00\u6b21\uff0c\u6301\u7eed6\u4e2a\u5468\u671f\uff0c\u6216\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u8bd5\u9a8c\u7684\u4e3b\u8981\u7ec8\u70b9\u4e3a\u6240\u6709\u968f\u673a\u60a3\u8005\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\uff0c\u5176\u4ed6\u7597\u6548\u7ed3\u5c40\u6307\u6807\u5305\u62ec\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3001\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u548c\u6301\u7eed\u7f13\u89e3\u65f6\u95f4\uff08DOR\uff09\uff0c\u7531\u76f2\u6001\u72ec\u7acb\u4e2d\u5fc3\u5ba1\u67e5\u59d4\u5458\u4f1a\uff08BICR\uff09\u6839\u636e\u6539\u826f\u7684RECIST\u6807\u51c6\u8fdb\u884c\u8bc4\u4f30\u3002\u63a2\u7d22\u6027\u7ec8\u70b9\u5305\u62ec\u5b89\u5168\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\uff0c\u514d\u75ab\u539f\u6027\u548c\u60a3\u8005\u62a5\u544a\u7684\u6cbb\u7597\u7ed3\u5c40\u3002<\/p>\n<p><b><u>\u5173\u4e8e\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624<\/u><\/b><\/p>\n<p>\u95f4\u76ae\u7624\u662f\u4e00\u79cd\u539f\u53d1\u4e8e\u95f4\u76ae\u7ec6\u80de\u7684\u7f55\u89c1\u4e14\u5177\u6709\u9ad8\u5ea6\u4fb5\u88ad\u6027\u7684\u6076\u6027\u80bf\u7624\uff0c\u4e2d\u56fd\u6bcf\u5e74\u786e\u8bca\u75c5\u4f8b\u7ea6\u4e3a3,000\u4f8b<sup>[4]<\/sup>\uff0c\u4ee5\u80f8\u819c\u95f4\u76ae\u7624\u4e3a\u4e3b<sup>[5]<\/sup>\u3002\u5176\u53d1\u75c5\u4e0e\u77f3\u68c9\u66b4\u9732\u9ad8\u5ea6\u76f8\u5173<sup>[6]<\/sup>\u3002\u56e0\u8bca\u65ad\u5ef6\u8bef\uff0c\u5927\u591a\u6570\u60a3\u8005\u5728\u786e\u8bca\u65f6\u75be\u75c5\u5df2\u8fdb\u5c55\u6216\u53d1\u751f\u8f6c\u79fb<sup>[7]<\/sup>\u3002\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u7684\u9884\u540e\u4e00\u822c\u8f83\u5dee\uff0c\u65e2\u5f80\u672a\u7ecf\u6cbb\u7597\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u60a3\u8005\u7684\u4e2d\u4f4d\u751f\u5b58\u671f\u572812\u81f314\u4e2a\u6708\u4e4b\u95f4\uff0c\u4e94\u5e74\u751f\u5b58\u7387\u7ea610%<sup>[8]<\/sup>\u3002<\/p>\n<p><b><u>\u5173\u4e8e\u6b27\u72c4\u6c83<\/u><\/b><b><u><sup>&reg;<\/sup><\/u><\/b><b><u>\uff08\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6ce8\u5c04\u6db2\uff09<\/u><\/b><\/p>\n<p><i>\u6b27\u72c4\u6c83<\/i>\u662f\u4e00\u79cdPD-1\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff0c\u72ec\u7279\u5730\u5229\u7528\u4eba\u4f53\u81ea\u8eab\u7684\u514d\u75ab\u7cfb\u7edf\u6765\u5e2e\u52a9\u673a\u4f53\u6062\u590d\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002\u8fd9\u79cd\u901a\u8fc7\u5229\u7528\u4eba\u4f53\u81ea\u8eab\u514d\u75ab\u7cfb\u7edf\u6765\u6297\u51fb\u764c\u75c7\u7684\u7279\u6027\uff0c\u4f7f<i>\u6b27\u72c4\u6c83<\/i>\u5df2\u6210\u4e3a\u591a\u7624\u80bf\u7684\u91cd\u8981\u6cbb\u7597\u9009\u62e9\u3002<\/p>\n<p>\u57fa\u4e8e\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u5728I-O\u6cbb\u7597\u9886\u57df\u7684\u79d1\u5b66\u4e13\u957f\uff0c<i>\u6b27\u72c4\u6c83<\/i>\u62e5\u6709\u5168\u7403\u9886\u5148\u7684\u7814\u53d1\u9879\u76ee\uff0c\u6db5\u76d6\u591a\u7624\u80bf\u7684\u5404\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5305\u62ec\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u622a\u81f3\u76ee\u524d\uff0c\u5df2\u6709\u8d85\u8fc735,000\u540d\u60a3\u8005\u5728\u4e34\u5e8a\u7814\u53d1\u9879\u76ee\u4e2d\u63a5\u53d7\u4e86<i>\u6b27\u72c4\u6c83<\/i>\u7684\u6cbb\u7597\u3002<i>\u6b27\u72c4\u6c83<\/i>\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6709\u52a9\u4e8e\u66f4\u6df1\u5165\u5730\u4e86\u89e3\u751f\u7269\u6807\u5fd7\u7269\u5bf9\u60a3\u8005\u6cbb\u7597\u9009\u62e9\u7684\u6f5c\u5728\u63d0\u793a\u4f5c\u7528\uff0c\u7279\u522b\u662f\u8bc6\u522b\u4e0d\u540cPD-L1\u8868\u8fbe\u6c34\u5e73\u7684\u60a3\u8005\u5982\u4f55\u80fd\u591f\u4ece<i>\u6b27\u72c4\u6c83<\/i>\u4e2d\u83b7\u76ca\u3002<\/p>\n<p>2014\u5e747\u6708\uff0c<i>\u6b27\u72c4\u6c83<\/i>\u6210\u4e3a\u5168\u7403\u9996\u4e2a\u83b7\u5f97\u76d1\u7ba1\u673a\u6784\u6279\u51c6\u7684PD-1\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff0c\u76ee\u524d<i>\u6b27\u72c4\u6c83<\/i>\u5df2\u5728\u8d85\u8fc765\u4e2a\u5730\u533a\u83b7\u5f97\u6279\u51c6\uff0c\u5305\u62ec\u7f8e\u56fd\u3001\u6b27\u76df\u3001\u65e5\u672c\u548c\u4e2d\u56fd\u30022015\u5e7410\u6708\uff0c<i>\u6b27\u72c4\u6c83<\/i>\u4e0e<i>\u9038\u6c83<\/i>\u8054\u5408\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\u6210\u4e3a\u9996\u4e2a\u83b7\u5f97\u76d1\u7ba1\u673a\u6784\u6279\u51c6\u7684\u514d\u75ab\u80bf\u7624\uff08I-O\uff09\u836f\u7269\u8054\u5408\u6cbb\u7597\u65b9\u6848\uff0c\u76ee\u524d\u5df2\u5728\u8d85\u8fc750\u4e2a\u5730\u533a\u83b7\u5f97\u6279\u51c6\uff0c\u5305\u62ec\u7f8e\u56fd\u548c\u6b27\u76df\u3002<\/p>\n<p><b><u>\u5173\u4e8e<\/u><\/b><b><u>\u9038\u6c83<\/u><\/b><b><u><sup>&reg;<\/sup><\/u><\/b><b><u>\uff08\u4f0a\u5339\u6728\u5355\u6297\u6ce8\u5c04\u6db2\uff09<\/u><\/b><\/p>\n<p><i>\u9038\u6c83<\/i>\u662f\u4e00\u79cd\u91cd\u7ec4\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\uff0c\u53ef\u4e0e\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u76f8\u5173\u6297\u539f4(CTLA-4) \u7ed3\u5408\u3002CTLA-4\u662f\u4e00\u79cdT\u7ec6\u80de\u6d3b\u5316\u7684\u8d1f\u8c03\u63a7\u56e0\u5b50\uff0c<i>\u9038\u6c83<\/i>\u4e0eCTLA-4\u7ed3\u5408\u540e\uff0c\u80fd\u963b\u65adCTLA-4\u4e0e\u5176\u914d\u4f53CD80\/CD86\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u963b\u65adCTLA-4\u5df2\u88ab\u8bc1\u660e\u80fd\u591f\u589e\u5f3aT\u7ec6\u80de\u7684\u6d3b\u5316\u548c\u589e\u6b96\uff0c\u5305\u62ec\u80bf\u7624\u6d78\u6da6\u6027\u6548\u5e94T\u7ec6\u80de\u7684\u6d3b\u5316\u548c\u589e\u6b96\u3002\u6291\u5236CTLA-4\u4fe1\u53f7\u4f20\u5bfc\u8fd8\u53ef\u51cf\u5f31\u8c03\u8282\u6027T\u7ec6\u80de\u7684\u529f\u80fd\uff0c\u8fd9\u53ef\u80fd\u6709\u52a9\u4e8eT\u7ec6\u80de\u53cd\u5e94\u6027\uff08\u5305\u62ec\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\uff09\u7684\u666e\u904d\u63d0\u5347\u30022011\u5e743\u670825\u65e5\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6<i>\u9038\u6c83<\/i>\uff083 mg \/ kg\uff09\u5355\u836f\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u65e0\u6cd5\u624b\u672f\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002\u76ee\u524d\uff0c<i>\u9038\u6c83<\/i>\u5df2\u572850\u591a\u4e2a\u56fd\u5bb6\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e0\u6cd5\u624b\u672f\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u3002<i>\u9038\u6c83<\/i>\u6b63\u5728\u591a\u4e2a\u80bf\u7624\u7c7b\u578b\u4e2d\u5f00\u5c55\u66f4\u5e7f\u6cdb\u7684\u63a2\u7d22\u3002<\/p>\n<div>\n<table cellspacing=\"0\" cellpadding=\"0\" border=\"0\" class=\"prntblns\">\n<tbody>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[1]&nbsp;American Cancer Society 2010-2016.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[2]&nbsp;Daniel H Sterman, et al. \u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u7684\u8868\u73b0\u3001\u521d\u59cb\u8bc4\u4f30\u548c\u9884\u540e UpToDate.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[3]&nbsp;\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u6307\u5357\u5de5\u4f5c\u59d4\u5458\u4f1a. \u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a(CSCO)\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u4e34\u5e8a\u5e94\u7528\u6307\u5357(2021\u5e74\u7248)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[4]&nbsp;<a target=\"_blank\" href=\"https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/160-china-fact-sheets.pdf\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/160-china-fact-sheets.pdf<\/a> <\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[5]&nbsp;Daniel H Sterman, et al. \u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u7684\u6d41\u884c\u75c5\u5b66. UpToDate.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[6]&nbsp;\u5510\u5584\u536b, \u7b49. \u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u6cbb\u7597\u7684\u7814\u7a76\u8fdb\u5c55. \u764c\u75c7\u8fdb\u5c55. 2019,17(11): 1245-1250<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[7]&nbsp;Daniel H Sterman, et al. \u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u7684\u8868\u73b0\u3001\u521d\u59cb\u8bc4\u4f30\u548c\u9884\u540e UpToDate.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[8]&nbsp;American Cancer Society 2010-2016.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6b27\u72c4\u6c83\u00ae\u8054\u5408\u9038\u6c83\u00ae\u6210\u4e3a\u56fd\u5185\u9996\u4e2a\u4e14\u76ee\u524d\u552f\u4e00\u83b7\u6279\u53cc\u514d\u75ab\u7597\u6cd5 \u8be5\u6279\u51c6\u57fa\u4e8eCheckMate-743\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\uff0c\u7814\u7a76\u7ed3\u679c\u8bc1\u5b9e\uff0c\u63a5\u53d7\u6b27\u72c4\u6c83\u8054\u5408\u9038\u6c83\u6cbb\u7597\u7684\u60a3\u8005\u603b\u751f\u5b58\u671f\u663e\u8457\u4f18\u4e8e\u6807\u51c6\u5316\u7597\uff1b\u8fd9\u662f\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u5728\u8be5\u60a3\u8005\u4eba\u7fa4\u4e2d\u9996\u4e2a\u83b7\u5f97\u9633\u6027\u7ed3\u679c\u7684III\u671f\u4e34\u5e8a\u7814\u7a76&nbsp; \u6b27\u72c4\u6c83\u8054\u5408\u9038\u6c83\u6210\u4e3a15\u5e74\u6765\u9996\u4e2a\u4e3a\u80f8\u819c\u95f4\u76ae\u7624\u60a3\u8005\u5e26\u6765\u751f\u5b58\u83b7\u76ca\u7684\u65b0\u7cfb\u7edf\u6027\u7597\u6cd5\uff0c\u6253\u7834\u591a\u5e74\u65e0\u65b0\u836f\u50f5\u5c40&nbsp; \u9038\u6c83\u6210\u4e3a\u56fd\u5185\u9996\u4e2a\u4e14\u76ee\u524d\u552f\u4e00\u83b7\u6279\u7684CTLA-4\u6291\u5236\u5242 \u4e0a\u6d772021\u5e746\u670811\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 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kg\uff09\u5355\u836f\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u65e0\u6cd5\u624b\u672f\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002\u76ee\u524d\uff0c\u9038\u6c83\u5df2\u572850\u591a\u4e2a\u56fd\u5bb6\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e0\u6cd5\u624b\u672f\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u3002\u9038\u6c83\u6b63\u5728\u591a\u4e2a\u80bf\u7624\u7c7b\u578b\u4e2d\u5f00\u5c55\u66f4\u5e7f\u6cdb\u7684\u63a2\u7d22\u3002 [1]&nbsp;American Cancer Society 2010-2016. [2]&nbsp;Daniel H Sterman, et al.&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2021061115580033939\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":8278,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-33939","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/33939","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=33939"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/33939\/revisions"}],"predecessor-version":[{"id":33940,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/33939\/revisions\/33940"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/8278"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=33939"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=33939"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=33939"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}