{"id":33837,"date":"2021-06-10T22:02:00","date_gmt":"2021-06-10T15:02:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021061022020033837"},"modified":"2021-06-11T21:39:04","modified_gmt":"2021-06-11T13:39:04","slug":"%e7%bb%bf%e5%8f%b6%e5%88%b6%e8%8d%af%e6%8a%97%e6%8a%91%e9%83%81%e7%97%871%e7%b1%bb%e6%96%b0%e8%8d%af%e7%9b%90%e9%85%b8%e5%ae%89%e8%88%92%e6%b3%95%e8%be%9b%e7%bc%93%e9%87%8a%e7%89%87%e4%b8%8a%e5%b8%82","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021061022020033837","title":{"rendered":"\u7eff\u53f6\u5236\u836f\u6297\u6291\u90c1\u75c71\u7c7b\u65b0\u836f\u76d0\u9178\u5b89\u8212\u6cd5\u8f9b\u7f13\u91ca\u7247\u4e0a\u5e02\u7533\u8bf7\u83b7CDE\u53d7\u7406"},"content":{"rendered":"

\u4e0a\u6d772021\u5e746\u670810\u65e5 \/\u7f8e\u901a\u793e\/ — \u7eff\u53f6\u5236\u836f\u96c6\u56e2\u5ba3\u5e03\uff0c\u5176\u81ea\u4e3b\u7814\u53d1\u7684\u4e2d\u56fd\u5316\u5b66\u836f\u54c11\u7c7b\u65b0\u836f\u2014\u2014\u76d0\u9178\u5b89\u8212\u6cd5\u8f9b\u7f13\u91ca\u7247\uff08LY03005\uff09\u7684\u4e0a\u5e02\u7533\u8bf7\u5df2\u6b63\u5f0f\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u53d7\u7406\u3002<\/p>\n

LY03005\u7528\u4e8e\u6cbb\u7597\u6291\u90c1\u75c7\uff0c\u57fa\u4e8e\u7eff\u53f6\u5236\u836f\u7684\u65b0\u6cbb\u7597\u5b9e\u4f53\/\u65b0\u5206\u5b50\u5b9e\u4f53\u6280\u672f\u5e73\u53f0\u5f00\u53d1\uff0c\u662f\u76ee\u524d\u5168\u7403\u552f\u4e00\u4e00\u4e2a\u4ece\u836f\u7269\u4f5c\u7528\u673a\u5236\u5230\u4e34\u5e8a\u6548\u679c\u5747\u88ab\u8bc1\u5b9e\u76845-\u7f9f\u8272\u80fa\uff085-HT\uff09\u3001\u53bb\u7532\u80be\u4e0a\u817a\u7d20\uff08NE\uff09\u548c\u591a\u5df4\u80fa\uff08DA\uff09\u4e09\u91cd\u518d\u6444\u53d6\u6291\u5236\u5242\uff08SNDRIs\uff09\uff0c\u4e3a\u540c\u7c7b\u9996\u521b\u4ea7\u54c1\uff08First-in-class\uff09\u3002<\/p>\n

LY03005\u7684\u4e0a\u5e02\u7533\u8bf7\u57fa\u4e8e\u5176\u5728\u4e2d\u56fd\u7684\u516d\u9879\u4e34\u5e8a\u7814\u7a76\u6240\u5f97\u7684\u4e34\u5e8a\u6570\u636e\u3002\u5176\u4e2d\uff0cIII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76\uff0c\u9a8c\u8bc1LY03005\u6cbb\u7597\u6291\u90c1\u75c7\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u8bd5\u9a8c\u5171\u7eb3\u5165558\u4f8b\u7b26\u5408DSM-5\u8bca\u65ad\u6807\u51c6\u7684\u4e2d\u56fd\u6210\u4eba\u6291\u90c1\u75c7\u60a3\u8005\uff0c\u6309\u71671:1:1\u7684\u6bd4\u4f8b\u968f\u673a\u63a5\u53d7LY03005 80 mg\u3001160 mg\u6216\u5b89\u6170\u5242\u4e3a\u671f8\u5468\u7684\u53cc\u76f2\u6cbb\u7597\u3002\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0cLY03005\u4e0d\u4ec5\u53ef\u4ee5\u5168\u9762\u3001\u7a33\u5b9a\u7684\u6539\u5584\u6291\u90c1\u75c7\u72b6\uff0c\u7279\u522b\u662f\u80fd\u591f\u5feb\u901f\u6539\u5584\u7126\u8651\u72b6\u6001\uff0c\u660e\u663e\u6539\u5584\u5feb\u611f\u7f3a\u5931\u548c\u8ba4\u77e5\u529f\u80fd\uff0c\u4e14\u4e0d\u5f15\u8d77\u55dc\u7761\u3001\u4e0d\u5f71\u54cd\u6027\u529f\u80fd\u3001\u4f53\u91cd\u548c\u8102\u4ee3\u8c22\u3002LY03005\u7684\u4e34\u5e8a\u6cbb\u7597\u5b66\u7279\u5f81\u5c06\u662f\u5b9e\u73b0\u60a3\u8005\u4ece\u6291\u90c1\u75c7\u7684\u6539\u5584\u5230\u91cd\u65b0\u878d\u5165\u793e\u4f1a\u7684\u5173\u952e\u3002<\/p>\n

LY03005<\/b>\u6709\u671b\u6253\u7834\u4e00\u7ebf\u6297\u6291\u90c1\u836f\u591a\u5e74\u4e0a\u5e02\u7a7a\u767d<\/b><\/p>\n

\u4f5c\u4e3a\u6700\u5e38\u89c1\u7684\u7cbe\u795e\u75be\u75c5\u4e4b\u4e00\uff0c\u6291\u90c1\u75c7\u5df2\u56f0\u6270\u5168\u7403\u60a3\u8005\u7ea63.5\u4ebf\u4eba[i]<\/sup>\u3002\u8be5\u75be\u75c5\u5177\u6709\u9ad8\u53d1\u75c5\u3001\u9ad8\u590d\u53d1\u3001\u9ad8\u81f4\u6b8b\u7684\u7279\u70b9\uff0c\u662f\u5168\u7403\u5404\u5730\u7684\u9996\u8981\u81f4\u6b8b\u539f\u56e0\uff0c\u4e5f\u662f\u5bfc\u81f4\u5168\u7403\u75be\u75c5\u8d1f\u62c5\u7684\u4e00\u9879\u91cd\u5927\u56e0\u7d20\u3002\u5728\u6211\u56fd\uff0c\u6291\u90c1\u75c7\u7684\u75c5\u60a3\u7387\u8fbe\u52304.2%[ii]<\/sup>\u3002\u57fa\u4e8e\u5e9e\u5927\u7684\u60a3\u8005\u9700\u6c42\uff0c2020\u5e74\uff0c\u6297\u6291\u90c1\u836f\u5728\u4e2d\u56fd\u7684\u5e02\u573a\u89c4\u6a21\u8fbe\u523063.1\u4ebf\u5143[iii]<\/sup>\u3002<\/p>\n

\u4e0e\u4e34\u5e8a\u9700\u6c42\u5f62\u6210\u5bf9\u6bd4\u7684\u662f\uff0c\u957f\u671f\u4ee5\u6765\u6297\u6291\u90c1\u65b0\u836f\u7684\u7814\u53d1\u8fdb\u5c55\u76f8\u5bf9\u8f83\u7f13\u3002\u76ee\u524d\uff0c\u5168\u7403\u6709\u6570\u5341\u79cd\u6297\u6291\u90c1\u836f\u7269\u5728\u7814\uff0c\u4f46\u662f\u8fd1\u5e74\u6765\u7684\u7814\u7a76\u5374\u9c9c\u6709\u91cd\u5927\u7a81\u7834\uff0c\u6700\u8fd1\u4e00\u4e2a\u5728\u7f8e\u56fdFDA\u83b7\u6279\u7684\u4e00\u7ebf\u6297\u6291\u90c1\u65b0\u836f\u8981\u8ffd\u6eaf\u81f32013\u5e74\u3002LY03005\u6709\u671b\u6253\u7834\u591a\u5e74\u6765\u4e00\u7ebf\u6297\u6291\u90c1\u65b0\u836f\u7814\u53d1\u7684\u50f5\u5c40\u3002<\/p>\n

\u56de\u6eaf\u6297\u6291\u90c1\u836f\u7684\u53d1\u5c55\u5386\u53f2\uff0c\u7b2c\u4e00\u4ee3\u6444\u53d6\u6291\u5236\u7c7b\u6297\u6291\u90c1\u836f\u662f\u9009\u62e9\u60275-HT\u518d\u6444\u53d6\u6291\u5236\u5242\uff08SSRIs\uff09\uff0c\u7528\u836f\u540e\u53ef\u6539\u5584\u6291\u90c1\u72b6\u6001\uff0c\u4f46\u65e0\u6cd5\u6539\u5584\u60a3\u8005\u884c\u52a8\u8fdf\u7f13\u7684\u72b6\u6001\uff0c\u4ea6\u4f1a\u81f4\u4f53\u91cd\u589e\u52a0\u3002\u6b64\u540e\uff0c\u7b2c\u4e8c\u4ee3\u6444\u53d6\u6291\u5236\u7c7b\u836f\u72695-HT\/NE\u9009\u62e9\u6027\u53cc\u91cd\u518d\u6444\u53d6\u6291\u5236\u5242\uff08SNRIs\uff09\u7684\u95ee\u4e16\uff0c\u4f7f\u60a3\u8005\u7684\u884c\u52a8\u8fdf\u7f13\u95ee\u9898\u548c\u4f53\u91cd\u589e\u52a0\u73b0\u8c61\u5f97\u5230\u6539\u5584\uff1b\u8fd9\u4e24\u7c7b\u836f\u7269\u662f\u76ee\u524d\u6cbb\u7597\u6291\u90c1\u75c7\u7684\u4e3b\u8981\u836f\u7269\uff0c\u4f46\u4e34\u5e8a\u4e0a\u4ecd\u7136\u5b58\u5728\u672a\u6ee1\u8db3\u7684\u6cbb\u7597\u9700\u6c42\uff0c\u4f8b\u5982\uff1a\u8d77\u6548\u7f13\u6162\u3001\u65e0\u6cd5\u6539\u5584\u60a3\u8005\u7684\u5feb\u611f\u7f3a\u5931\uff08\u5956\u52b1\u9a71\u52a8\uff09\u548c\u8ba4\u77e5\u80fd\u529b\uff0c\u540c\u65f6\u4f1a\u5bfc\u81f4\u60a3\u8005\u7684\u6027\u529f\u80fd\u969c\u788d\u7b49\u3002<\/p>\n

LY03005\u4f5c\u4e3a\u4e00\u79cd\u4e09\u91cd\u518d\u6444\u53d6\u6291\u5236\u5242\uff08SNDRIs\uff0c\u76f8\u6bd4\u53cc\u91cd\u518d\u6444\u53d6\u6291\u5236\u5242\uff08SNRIs\uff09\u589e\u52a0\u4e86DA\u7684\u518d\u6444\u53d6\u6291\u5236\uff0c\u4e0e\u4e4b\u76f8\u5173\u7684\u5956\u8d4f\u673a\u5236\u6709\u52a9\u4e8e\u6539\u5584\u60a3\u8005\u7684\u5feb\u611f\u7f3a\u5931\u73b0\u8c61\uff0c\u6fc0\u6d3b\u5927\u8111\u76ae\u5c42\u7684BDNF\uff08\u8111\u6e90\u6027\u795e\u7ecf\u751f\u957f\u56e0\u5b50\uff09\u53ef\u6539\u5584\u60a3\u8005\u8ba4\u77e5\u80fd\u529b\uff0c\u6fc0\u6d3b\u4e0b\u4e18\u8111-\u6027\u817a\u8f74\u6709\u52a9\u4e8e\u6539\u5584\u60a3\u8005\u6027\u529f\u80fd\u3002<\/p>\n

\u9664\u4e86\u4e2d\u56fd\u4ee5\u5916\uff0cLY03005\u4e5f\u5206\u522b\u5728\u7f8e\u56fd\u8fdb\u5165\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u9636\u6bb5\uff0c\u5728\u65e5\u672c\u5b8c\u6210I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u7eff\u53f6\u5236\u836f\u8ba1\u5212\u5728\u7f8e\u56fd\u3001\u4e2d\u56fd\u3001\u65e5\u672c\u3001\u6b27\u6d32\u53ca\u5176\u4ed6\u56fd\u5bb6\u548c\u5730\u533a\u6ce8\u518c\u548c\u4e0a\u5e02\u8be5\u4ea7\u54c1\u3002\u516c\u53f8\u62e5\u6709\u6db5\u76d6LY03005\u5316\u5b66\u6210\u4efd\u3001\u6676\u4f53\u5f62\u6001\u53ca\u5236\u5242\u7684\u4e13\u5229\uff0c\u5176\u4e2d\u5316\u5b66\u6210\u4efd\u53ca\u6676\u4f53\u5f62\u6001\u7684\u4e13\u5229\u5df2\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u6b27\u6d32\u3001\u65e5\u672c\u53ca\u97e9\u56fd\u7b49\u56fd\u5bb6\u548c\u5730\u533a\u83b7\u5f97\u3002<\/p>\n

\u4e2d\u67a2\u795e\u7ecf\u4ea7\u54c1\u7ec4\u5408\u4e30\u5bcc\uff0c\u6f5c\u529b\u54c1\u79cd\u83b7\u7a81\u7834\u8fdb\u5c55<\/b><\/p>\n

\u5305\u62ec\u6291\u90c1\u75c7\u5728\u5185\u7684\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u6cbb\u7597\u9886\u57df\u662f\u7eff\u53f6\u5236\u836f\u7684\u6838\u5fc3\u6218\u7565\u9886\u57df\u4e4b\u4e00\u3002\u516c\u53f8\u4ece\u4e34\u5e8a\u9700\u6c42\u51fa\u53d1\uff0c\u57fa\u4e8e\u65b0\u5206\u5b50\u5b9e\u4f53\u6280\u672f\u5e73\u53f0\u3001\u65b0\u578b\u5236\u5242\u6280\u672f\u5e73\u53f0\u7b49\u521b\u65b0\u6280\u672f\u5e73\u53f0\uff0c\u73b0\u5df2\u62e5\u6709\u4e00\u7cfb\u5217\u5dee\u5f02\u5316\u7684\u521b\u65b0\u836f\u53ca\u521b\u65b0\u5236\u5242\u5728\u7814\u4ea7\u54c1\uff0c\u6f5c\u529b\u54c1\u79cd\u4e0d\u65ad\u6536\u83b7\u7a81\u7834\u8fdb\u5c55\u3002 <\/p>\n

\u4eca\u5e745\u6708\uff0c\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u521b\u65b0\u5236\u5242\u2014\u2014\u5229\u65af\u7684\u660e\u591a\u65e5\u900f\u76ae\u8d34\u5242\u83b7\u5f97\u6b27\u76df\u591a\u4e2a\u56fd\u5bb6\u7684\u4e0a\u5e02\u8bb8\u53ef\u8d44\u683c\uff1b\u4eca\u5e741\u6708\uff0c\u6cbb\u7597\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u6ce8\u5c04\u7528\u5229\u57f9\u916e\u5fae\u7403II\uff08\u745e\u6b23\u59a5®<\/sup>\uff09\u5728\u4e2d\u56fd\u83b7\u5f97\u4e0a\u5e02\u6279\u51c6\uff0c\u8be5\u4ea7\u54c1\u540c\u65f6\u4e5f\u662f\u6211\u56fd\u9996\u4e2a\u81ea\u4e3b\u521b\u65b0\u5fae\u7403\u5236\u5242\uff1b\u5229\u65af\u7684\u660e\u5355\u65e5\u900f\u76ae\u8d34\u5242\uff08\u91d1\u65af\u660e®<\/sup>\uff09\u4e5f\u5df2\u5411\u8fd150\u4e2a\u57ce\u5e02\u7684\u533b\u9662\u548c\u836f\u623f\u4f9b\u5e94\u3002\u5728\u4e2d\u56fd\uff0c\u516c\u53f8\u5df2\u7ec4\u5efa\u4e86\u4e00\u652f\u4e13\u4e1a\u7684\u5e02\u573a\u8425\u9500\u56e2\u961f\u53ca\u4e94\u4e2a\u8425\u9500\u5927\u533a\uff0c\u4e1a\u52a1\u8986\u76d6\u5168\u56fd\u5404\u5927\u533a\u57df\u3002<\/p>\n

\u4e0d\u4ec5\u5982\u6b64\uff0c\u56f4\u7ed5\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff0c\u7eff\u53f6\u5236\u836f\u8fd8\u6709\u591a\u4e2a\u5728\u7814\u65b0\u836f\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u6b27\u6d32\u7b49\u56fd\u5bb6\u548c\u5730\u533a\u8fdb\u5165\u4e34\u5e8a\u540e\u671f\u548c\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u9636\u6bb5\uff0c\u6db5\u76d6\u5e15\u91d1\u68ee\u75c5\u3001\u53cc\u76f8\u60c5\u611f\u969c\u788d\u7b49\u79cd\u75be\u75c5\u3002\u516c\u53f8\u6b63\u5728\u52a0\u901f\u63a8\u8fdb\u5728\u8be5\u6cbb\u7597\u9886\u57df\u7684\u5168\u7403\u6218\u7565\u5e03\u5c40\uff0c\u901a\u8fc7\u6301\u7eed\u6784\u5efa\u4e30\u5bcc\u7684\u4ea7\u54c1\u7ec4\u5408\u3001\u6df1\u5316\u5546\u4e1a\u5316\u8fd0\u8425\u80fd\u529b\uff0c\u5f3a\u5316\u5728\u8be5\u9886\u57df\u7684\u6838\u5fc3\u7ade\u4e89\u4f18\u52bf\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u4e0a\u6d772021\u5e746\u670810\u65e5 \/\u7f8e\u901a\u793e\/ — \u7eff\u53f6\u5236\u836f\u96c6\u56e2\u5ba3\u5e03\uff0c\u5176\u81ea\u4e3b\u7814\u53d1\u7684\u4e2d\u56fd\u5316\u5b66\u836f\u54c11\u7c7b\u65b0\u836f\u2014\u2014\u76d0\u9178\u5b89\u8212\u6cd5\u8f9b\u7f13\u91ca\u7247\uff08LY03005\uff09\u7684\u4e0a\u5e02\u7533\u8bf7\u5df2\u6b63\u5f0f\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u53d7\u7406\u3002 LY03005\u7528\u4e8e\u6cbb\u7597\u6291\u90c1\u75c7\uff0c\u57fa\u4e8e\u7eff\u53f6\u5236\u836f\u7684\u65b0\u6cbb\u7597\u5b9e\u4f53\/\u65b0\u5206\u5b50\u5b9e\u4f53\u6280\u672f\u5e73\u53f0\u5f00\u53d1\uff0c\u662f\u76ee\u524d\u5168\u7403\u552f\u4e00\u4e00\u4e2a\u4ece\u836f\u7269\u4f5c\u7528\u673a\u5236\u5230\u4e34\u5e8a\u6548\u679c\u5747\u88ab\u8bc1\u5b9e\u76845-\u7f9f\u8272\u80fa\uff085-HT\uff09\u3001\u53bb\u7532\u80be\u4e0a\u817a\u7d20\uff08NE\uff09\u548c\u591a\u5df4\u80fa\uff08DA\uff09\u4e09\u91cd\u518d\u6444\u53d6\u6291\u5236\u5242\uff08SNDRIs\uff09\uff0c\u4e3a\u540c\u7c7b\u9996\u521b\u4ea7\u54c1\uff08First-in-class\uff09\u3002 LY03005\u7684\u4e0a\u5e02\u7533\u8bf7\u57fa\u4e8e\u5176\u5728\u4e2d\u56fd\u7684\u516d\u9879\u4e34\u5e8a\u7814\u7a76\u6240\u5f97\u7684\u4e34\u5e8a\u6570\u636e\u3002\u5176\u4e2d\uff0cIII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76\uff0c\u9a8c\u8bc1LY03005\u6cbb\u7597\u6291\u90c1\u75c7\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u8bd5\u9a8c\u5171\u7eb3\u5165558\u4f8b\u7b26\u5408DSM-5\u8bca\u65ad\u6807\u51c6\u7684\u4e2d\u56fd\u6210\u4eba\u6291\u90c1\u75c7\u60a3\u8005\uff0c\u6309\u71671:1:1\u7684\u6bd4\u4f8b\u968f\u673a\u63a5\u53d7LY03005 80 mg\u3001160 mg\u6216\u5b89\u6170\u5242\u4e3a\u671f8\u5468\u7684\u53cc\u76f2\u6cbb\u7597\u3002\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0cLY03005\u4e0d\u4ec5\u53ef\u4ee5\u5168\u9762\u3001\u7a33\u5b9a\u7684\u6539\u5584\u6291\u90c1\u75c7\u72b6\uff0c\u7279\u522b\u662f\u80fd\u591f\u5feb\u901f\u6539\u5584\u7126\u8651\u72b6\u6001\uff0c\u660e\u663e\u6539\u5584\u5feb\u611f\u7f3a\u5931\u548c\u8ba4\u77e5\u529f\u80fd\uff0c\u4e14\u4e0d\u5f15\u8d77\u55dc\u7761\u3001\u4e0d\u5f71\u54cd\u6027\u529f\u80fd\u3001\u4f53\u91cd\u548c\u8102\u4ee3\u8c22\u3002LY03005\u7684\u4e34\u5e8a\u6cbb\u7597\u5b66\u7279\u5f81\u5c06\u662f\u5b9e\u73b0\u60a3\u8005\u4ece\u6291\u90c1\u75c7\u7684\u6539\u5584\u5230\u91cd\u65b0\u878d\u5165\u793e\u4f1a\u7684\u5173\u952e\u3002 LY03005\u6709\u671b\u6253\u7834\u4e00\u7ebf\u6297\u6291\u90c1\u836f\u591a\u5e74\u4e0a\u5e02\u7a7a\u767d \u4f5c\u4e3a\u6700\u5e38\u89c1\u7684\u7cbe\u795e\u75be\u75c5\u4e4b\u4e00\uff0c\u6291\u90c1\u75c7\u5df2\u56f0\u6270\u5168\u7403\u60a3\u8005\u7ea63.5\u4ebf\u4eba[i]\u3002\u8be5\u75be\u75c5\u5177\u6709\u9ad8\u53d1\u75c5\u3001\u9ad8\u590d\u53d1\u3001\u9ad8\u81f4\u6b8b\u7684\u7279\u70b9\uff0c\u662f\u5168\u7403\u5404\u5730\u7684\u9996\u8981\u81f4\u6b8b\u539f\u56e0\uff0c\u4e5f\u662f\u5bfc\u81f4\u5168\u7403\u75be\u75c5\u8d1f\u62c5\u7684\u4e00\u9879\u91cd\u5927\u56e0\u7d20\u3002\u5728\u6211\u56fd\uff0c\u6291\u90c1\u75c7\u7684\u75c5\u60a3\u7387\u8fbe\u52304.2%[ii]\u3002\u57fa\u4e8e\u5e9e\u5927\u7684\u60a3\u8005\u9700\u6c42\uff0c2020\u5e74\uff0c\u6297\u6291\u90c1\u836f\u5728\u4e2d\u56fd\u7684\u5e02\u573a\u89c4\u6a21\u8fbe\u523063.1\u4ebf\u5143[iii]\u3002 \u4e0e\u4e34\u5e8a\u9700\u6c42\u5f62\u6210\u5bf9\u6bd4\u7684\u662f\uff0c\u957f\u671f\u4ee5\u6765\u6297\u6291\u90c1\u65b0\u836f\u7684\u7814\u53d1\u8fdb\u5c55\u76f8\u5bf9\u8f83\u7f13\u3002\u76ee\u524d\uff0c\u5168\u7403\u6709\u6570\u5341\u79cd\u6297\u6291\u90c1\u836f\u7269\u5728\u7814\uff0c\u4f46\u662f\u8fd1\u5e74\u6765\u7684\u7814\u7a76\u5374\u9c9c\u6709\u91cd\u5927\u7a81\u7834\uff0c\u6700\u8fd1\u4e00\u4e2a\u5728\u7f8e\u56fdFDA\u83b7\u6279\u7684\u4e00\u7ebf\u6297\u6291\u90c1\u65b0\u836f\u8981\u8ffd\u6eaf\u81f32013\u5e74\u3002LY03005\u6709\u671b\u6253\u7834\u591a\u5e74\u6765\u4e00\u7ebf\u6297\u6291\u90c1\u65b0\u836f\u7814\u53d1\u7684\u50f5\u5c40\u3002 \u56de\u6eaf\u6297\u6291\u90c1\u836f\u7684\u53d1\u5c55\u5386\u53f2\uff0c\u7b2c\u4e00\u4ee3\u6444\u53d6\u6291\u5236\u7c7b\u6297\u6291\u90c1\u836f\u662f\u9009\u62e9\u60275-HT\u518d\u6444\u53d6\u6291\u5236\u5242\uff08SSRIs\uff09\uff0c\u7528\u836f\u540e\u53ef\u6539\u5584\u6291\u90c1\u72b6\u6001\uff0c\u4f46\u65e0\u6cd5\u6539\u5584\u60a3\u8005\u884c\u52a8\u8fdf\u7f13\u7684\u72b6\u6001\uff0c\u4ea6\u4f1a\u81f4\u4f53\u91cd\u589e\u52a0\u3002\u6b64\u540e\uff0c\u7b2c\u4e8c\u4ee3\u6444\u53d6\u6291\u5236\u7c7b\u836f\u72695-HT\/NE\u9009\u62e9\u6027\u53cc\u91cd\u518d\u6444\u53d6\u6291\u5236\u5242\uff08SNRIs\uff09\u7684\u95ee\u4e16\uff0c\u4f7f\u60a3\u8005\u7684\u884c\u52a8\u8fdf\u7f13\u95ee\u9898\u548c\u4f53\u91cd\u589e\u52a0\u73b0\u8c61\u5f97\u5230\u6539\u5584\uff1b\u8fd9\u4e24\u7c7b\u836f\u7269\u662f\u76ee\u524d\u6cbb\u7597\u6291\u90c1\u75c7\u7684\u4e3b\u8981\u836f\u7269\uff0c\u4f46\u4e34\u5e8a\u4e0a\u4ecd\u7136\u5b58\u5728\u672a\u6ee1\u8db3\u7684\u6cbb\u7597\u9700\u6c42\uff0c\u4f8b\u5982\uff1a\u8d77\u6548\u7f13\u6162\u3001\u65e0\u6cd5\u6539\u5584\u60a3\u8005\u7684\u5feb\u611f\u7f3a\u5931\uff08\u5956\u52b1\u9a71\u52a8\uff09\u548c\u8ba4\u77e5\u80fd\u529b\uff0c\u540c\u65f6\u4f1a\u5bfc\u81f4\u60a3\u8005\u7684\u6027\u529f\u80fd\u969c\u788d\u7b49\u3002 LY03005\u4f5c\u4e3a\u4e00\u79cd\u4e09\u91cd\u518d\u6444\u53d6\u6291\u5236\u5242\uff08SNDRIs\uff0c\u76f8\u6bd4\u53cc\u91cd\u518d\u6444\u53d6\u6291\u5236\u5242\uff08SNRIs\uff09\u589e\u52a0\u4e86DA\u7684\u518d\u6444\u53d6\u6291\u5236\uff0c\u4e0e\u4e4b\u76f8\u5173\u7684\u5956\u8d4f\u673a\u5236\u6709\u52a9\u4e8e\u6539\u5584\u60a3\u8005\u7684\u5feb\u611f\u7f3a\u5931\u73b0\u8c61\uff0c\u6fc0\u6d3b\u5927\u8111\u76ae\u5c42\u7684BDNF\uff08\u8111\u6e90\u6027\u795e\u7ecf\u751f\u957f\u56e0\u5b50\uff09\u53ef\u6539\u5584\u60a3\u8005\u8ba4\u77e5\u80fd\u529b\uff0c\u6fc0\u6d3b\u4e0b\u4e18\u8111-\u6027\u817a\u8f74\u6709\u52a9\u4e8e\u6539\u5584\u60a3\u8005\u6027\u529f\u80fd\u3002 \u9664\u4e86\u4e2d\u56fd\u4ee5\u5916\uff0cLY03005\u4e5f\u5206\u522b\u5728\u7f8e\u56fd\u8fdb\u5165\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u9636\u6bb5\uff0c\u5728\u65e5\u672c\u5b8c\u6210I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u7eff\u53f6\u5236\u836f\u8ba1\u5212\u5728\u7f8e\u56fd\u3001\u4e2d\u56fd\u3001\u65e5\u672c\u3001\u6b27\u6d32\u53ca\u5176\u4ed6\u56fd\u5bb6\u548c\u5730\u533a\u6ce8\u518c\u548c\u4e0a\u5e02\u8be5\u4ea7\u54c1\u3002\u516c\u53f8\u62e5\u6709\u6db5\u76d6LY03005\u5316\u5b66\u6210\u4efd\u3001\u6676\u4f53\u5f62\u6001\u53ca\u5236\u5242\u7684\u4e13\u5229\uff0c\u5176\u4e2d\u5316\u5b66\u6210\u4efd\u53ca\u6676\u4f53\u5f62\u6001\u7684\u4e13\u5229\u5df2\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u6b27\u6d32\u3001\u65e5\u672c\u53ca\u97e9\u56fd\u7b49\u56fd\u5bb6\u548c\u5730\u533a\u83b7\u5f97\u3002 \u4e2d\u67a2\u795e\u7ecf\u4ea7\u54c1\u7ec4\u5408\u4e30\u5bcc\uff0c\u6f5c\u529b\u54c1\u79cd\u83b7\u7a81\u7834\u8fdb\u5c55 \u5305\u62ec\u6291\u90c1\u75c7\u5728\u5185\u7684\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u6cbb\u7597\u9886\u57df\u662f\u7eff\u53f6\u5236\u836f\u7684\u6838\u5fc3\u6218\u7565\u9886\u57df\u4e4b\u4e00\u3002\u516c\u53f8\u4ece\u4e34\u5e8a\u9700\u6c42\u51fa\u53d1\uff0c\u57fa\u4e8e\u65b0\u5206\u5b50\u5b9e\u4f53\u6280\u672f\u5e73\u53f0\u3001\u65b0\u578b\u5236\u5242\u6280\u672f\u5e73\u53f0\u7b49\u521b\u65b0\u6280\u672f\u5e73\u53f0\uff0c\u73b0\u5df2\u62e5\u6709\u4e00\u7cfb\u5217\u5dee\u5f02\u5316\u7684\u521b\u65b0\u836f\u53ca\u521b\u65b0\u5236\u5242\u5728\u7814\u4ea7\u54c1\uff0c\u6f5c\u529b\u54c1\u79cd\u4e0d\u65ad\u6536\u83b7\u7a81\u7834\u8fdb\u5c55\u3002  \u4eca\u5e745\u6708\uff0c\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u521b\u65b0\u5236\u5242\u2014\u2014\u5229\u65af\u7684\u660e\u591a\u65e5\u900f\u76ae\u8d34\u5242\u83b7\u5f97\u6b27\u76df\u591a\u4e2a\u56fd\u5bb6\u7684\u4e0a\u5e02\u8bb8\u53ef\u8d44\u683c\uff1b\u4eca\u5e741\u6708\uff0c\u6cbb\u7597\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u6ce8\u5c04\u7528\u5229\u57f9\u916e\u5fae\u7403II\uff08\u745e\u6b23\u59a5®\uff09\u5728\u4e2d\u56fd\u83b7\u5f97\u4e0a\u5e02\u6279\u51c6\uff0c\u8be5\u4ea7\u54c1\u540c\u65f6\u4e5f\u662f\u6211\u56fd\u9996\u4e2a\u81ea\u4e3b\u521b\u65b0\u5fae\u7403\u5236\u5242\uff1b\u5229\u65af\u7684\u660e\u5355\u65e5\u900f\u76ae\u8d34\u5242\uff08\u91d1\u65af\u660e®\uff09\u4e5f\u5df2\u5411\u8fd150\u4e2a\u57ce\u5e02\u7684\u533b\u9662\u548c\u836f\u623f\u4f9b\u5e94\u3002\u5728\u4e2d\u56fd\uff0c\u516c\u53f8\u5df2\u7ec4\u5efa\u4e86\u4e00\u652f\u4e13\u4e1a\u7684\u5e02\u573a\u8425\u9500\u56e2\u961f\u53ca\u4e94\u4e2a\u8425\u9500\u5927\u533a\uff0c\u4e1a\u52a1\u8986\u76d6\u5168\u56fd\u5404\u5927\u533a\u57df\u3002 \u4e0d\u4ec5\u5982\u6b64\uff0c\u56f4\u7ed5\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff0c\u7eff\u53f6\u5236\u836f\u8fd8\u6709\u591a\u4e2a\u5728\u7814\u65b0\u836f\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u6b27\u6d32\u7b49\u56fd\u5bb6\u548c\u5730\u533a\u8fdb\u5165\u4e34\u5e8a\u540e\u671f\u548c\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u9636\u6bb5\uff0c\u6db5\u76d6\u5e15\u91d1\u68ee\u75c5\u3001\u53cc\u76f8\u60c5\u611f\u969c\u788d\u7b49\u79cd\u75be\u75c5\u3002\u516c\u53f8\u6b63\u5728\u52a0\u901f\u63a8\u8fdb\u5728\u8be5\u6cbb\u7597\u9886\u57df\u7684\u5168\u7403\u6218\u7565\u5e03\u5c40\uff0c\u901a\u8fc7\u6301\u7eed\u6784\u5efa\u4e30\u5bcc\u7684\u4ea7\u54c1\u7ec4\u5408\u3001\u6df1\u5316\u5546\u4e1a\u5316\u8fd0\u8425\u80fd\u529b\uff0c\u5f3a\u5316\u5728\u8be5\u9886\u57df\u7684\u6838\u5fc3\u7ade\u4e89\u4f18\u52bf\u3002… Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":8278,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-33837","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/33837","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=33837"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/33837\/revisions"}],"predecessor-version":[{"id":33838,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/33837\/revisions\/33838"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/8278"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=33837"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=33837"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=33837"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}