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<\/li>\n<li>IBI326\u5728\u4f53\u5185\u6301\u4e45\u5b58\u7eed\uff1aIBI326\u6269\u589e\u7684\u4e2d\u4f4d\u8fbe\u5cf0\u65f6\u95f4\u4e3a\u56de\u8f93\u540e12\uff087~17\uff09\u5929\u3002\u622a\u6b62\u5230\u6570\u636e\u622a\u6b62\u65e5\u671f\uff0c\u5df2\u67093\u4f8b\u53d7\u8bd5\u8005\u4f53\u5185\u68c0\u6d4b\u5230IBI326\u5b58\u7eed\u8d85\u8fc72\u5e74\uff0c\u5176\u4e2d\u7b2c\u4e00\u4f8b\u53d7\u8bd5\u8005\u7597\u6548\u6301\u7eedsCR\u3002 <\/li>\n<li>IBI326\u5177\u6709\u8f83\u4f4e\u7684\u514d\u75ab\u539f\u6027\uff1a35\u4f8b\u53d7\u8bd5\u8005\u4e2d\u4ec52\u4f8b\uff085.7%\uff09\u53d7\u8bd5\u8005\u5728\u56de\u8f93\u540e\u68c0\u6d4b\u5230\u6297\u836f\u6297\u4f53\uff08ADA\uff09\u7684\u4ea7\u751f\uff0c\u514d\u75ab\u539f\u6027\u660e\u663e\u4f4e\u4e8e\u540c\u9776\u70b9\u975e\u4eba\u6e90CAR-T\u7ec6\u80de\u4ea7\u54c1\u3002<\/li>\n<\/ul>\n<p>\u57282019\u5e74\u4e3e\u884c\u7684\u7b2c61\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u5e74\u4f1a\uff08ASH\uff09\u4e0a\uff0c\u4fe1\u8fbe\u751f\u7269\u4e0e\u9a6f\u9e7f\u533b\u7597\u4e00\u8d77\u53e3\u5934\u62a5\u544a\u4e86\u53cc\u65b9\u5171\u540c\u7814\u53d1\u7684\u5168\u4eba\u6e90BCMA CAR-T\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u4e00\u9879\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff08\u6458\u8981#582\uff09\u3002\u6570\u636e\u8868\u660eIBI326\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u3001\u4f18\u5f02\u7684\u6709\u6548\u6027\u548c\u6301\u4e45\u7684\u5b58\u7eed\u6027\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u8be5\u7814\u7a76\u8fd8\u5165\u7ec4\u4e864\u4f8b\u65e2\u5f80\u63a5\u53d7\u8fc7\u9f20\u6e90BCMA CAR-T\u6cbb\u7597\u540e\u590d\u53d1\u7684\u60a3\u8005\uff0c\u7814\u7a76\u7ed3\u679c\u8868\u660eIBI326\u53ef\u4e3a\u9f20\u6e90\u6027CAR-T\u6cbb\u7597\u540e\u590d\u53d1\u7684\u60a3\u8005\u63d0\u4f9b\u6709\u6548\u6cbb\u7597\u7684\u9009\u62e9\u3002<\/p>\n<p>2021\u5e746\u6708\uff0c\u8bc4\u4ef7IBI326\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u6709\u6548\u6027\u53ca\u5b89\u5168\u6027\u7684\u4e34\u5e8a\u7814\u7a76\u7684\u521d\u6b65\u7ed3\u679c\u6b63\u5f0f\u5728\u8840\u6db2\u9886\u57df\u9876\u7ea7\u5b66\u672f\u671f\u520a\u300aBlood\u300b\u4e0a\u53d1\u8868\uff1a\u300aA Phase 1 Study of a Novel Fully Human BCMA-targeting CAR (CT103A) in Patients with Relapsed\/Refractory Multiple Myeloma\u300b\u3002\u8be5\u7814\u7a76\u4e2dIBI326\u5728\u4f53\u5185\u6301\u4e45\u5b58\u7eed\u7684\u72ec\u7279\u4f18\u52bf\u4ee5\u53ca\u4f5c\u8005\u5bf9\u4e8e\u75be\u75c5\u518d\u6cbb\u7597\u524d\u666f\u7684\u63a2\u8ba8\u5f15\u53d1\u4e86\u300aBlood\u300b\u6742\u5fd7\u9ad8\u5ea6\u5173\u6ce8\u5e76\u5165\u9009featured article\u4e34\u5e8a\u7814\u7a76\uff0c\u540c\u671f\u83b7\u5f97\u4f26\u6566\u5927\u5b66\u5b66\u9662\uff08UCL\uff09\u764c\u75c7\u7814\u7a76\u9662\u6743\u5a01\u4e13\u5bb6\u4eae\u70b9\u8ff0\u8bc4\u300aBCMA CARs in multiple myeloma: room for more?\u300b(DOI 10.1182\/blood.2021010833)\u3002<\/p>\n<p>\u4fe1\u8fbe\u751f\u7269\u4e34\u5e8a\u5f00\u53d1\u9ad8\u7ea7\u526f\u603b\u88c1\u5468\u8f89\u535a\u58eb\u8868\u793a\uff1a\u201c\u5f88\u9ad8\u5174\u770b\u5230IBI326\uff08\u9a6f\u9e7f\u533b\u7597\u7814\u53d1\u4ee3\u53f7CT103A\uff09\u4f18\u5f02\u7684\u4e34\u5e8a\u6570\u636e\u83b7\u5f97\u4e86\u6b27\u6d32\u8840\u6db2\u5b66\u5e74\u4f1a\u7684\u5927\u529b\u80af\u5b9a\u3002\u5c24\u5176\u5bf9\u4e8e\u65e2\u5f80\u975e\u4eba\u6e90CART\u6cbb\u7597\u5931\u8d25\u53d7\u8bd5\u8005\u4ecd\u6709\u8f83\u597d\u7684\u4e34\u5e8a\u83b7\u76ca\uff0c\u4e3a\u590d\u53d1\/\u96be\u6cbb\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u63d0\u4f9b\u4e86\u66f4\u4f18\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u671f\u5f85\u8be5\u6b3e\u7ec6\u80de\u7597\u6cd5\u7684\u65e9\u65e5\u4e0a\u5e02\uff0c\u9020\u798f\u60a3\u8005\u3002\u201d<\/p>\n<p>\u9a6f\u9e7f\u533b\u7597CEO\u6c6a\u6587\u535a\u58eb\u8868\u793a\uff1a\u201c\u5f88\u9ad8\u5174\u770b\u5230\u6211\u4eec\u7684\u4f18\u8d28\u4e34\u5e8a\u6570\u636e\u5728\u9876\u5c16\u56fd\u9645\u4f1a\u8bae<span id=\"spanHghlt3aff\">&nbsp;&#8212;<\/span> \u6b27\u6d32\u8840\u6db2\u5b66\u5e74\u4f1a\u4e0a\u62ab\u9732\uff0c\u8fd9\u4e5f\u662f\u672c\u6b21EHA\u4f1a\u8bae\u4e2d\u552f\u4e00\u7684\u4e00\u4e2a\u6765\u81ea\u4e2d\u56fd\u7684BCMA CAR-T\u7597\u6cd5oral\u62a5\u544a\u3002\u672c\u6b21\u66f4\u65b0\u7684\u6570\u636e\u518d\u6b21\u9a8c\u8bc1\u4e86CT103A\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u4f18\u52bf\u548c\u7279\u70b9\u3002\u7279\u522b\u8981\u5f3a\u8c03\u7684\u662f\uff0c\u6211\u4eec\u5728\u672c\u6b21\u62ab\u9732\u7684\u6570\u636e\u4e2d\u7eb3\u5165\u4e868\u4f8b\u5408\u5e76\u9ad3\u5916\u75c5\u7076\u548c10\u4f8b\u65e2\u5f80\u975e\u4eba\u6e90CAR-T\u6cbb\u7597\u5931\u8d25\u7684\u53d7\u8bd5\u8005\uff0c\u6240\u6709\u53d7\u8bd5\u8005\u5747\u6709\u4e34\u5e8a\u83b7\u76ca\u3002\u9a6f\u9e7f\u56e2\u961f\u5c06\u7ee7\u7eed\u4ee5\u521b\u65b0\u7684\u4e34\u5e8a\u5f00\u53d1\u7b56\u7565\uff0c\u8fdb\u4e00\u6b65\u8bc1\u660eCT103A\u7684\u4f18\u52bf\u3002\u6211\u4eec\u4e5f\u975e\u5e38\u671f\u5f85\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u540c\u6d4e\u533b\u5b66\u9662\u9644\u5c5e\u540c\u6d4e\u533b\u9662\u674e\u6625\u854a\u6559\u6388\u7684\u6b64\u6b21EHA\u5927\u4f1a\u7684\u53e3\u5934\u62a5\u544a\u3002\u201d <\/p>\n<p>\u62a5\u544a\u8be6\u60c5\uff1a<\/p>\n<p>\u6458\u8981\uff1aS194 \u4e00\u9879\u65b0\u7684\u5168\u4eba\u6e90BCMA CAR-T\u7ec6\u80de\u7597\u6cd5CT103A\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u7814\u7a76\u6210\u679c<br \/>\u5f62\u5f0f\uff1a\u53e3\u5934\u62a5\u544a<br \/>\u7814\u8ba8\u4f1a\u4e3b\u9898\uff1aT cell re-directing therapies in relapsed\/refractory multiple myeloma<\/p>\n<p><b>\u5173\u4e8e\u591a\u53d1\u6027\u9aa8\u9ad3\u7624<\/b><\/p>\n<p>\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u662f\u6700\u5e38\u89c1\u7684\u8840\u6db2\u764c\u75c7\u4e4b\u4e00\uff0c\u662f\u4e00\u79cd\u514b\u9686\u6027\u6d46\u7ec6\u80de\u5f02\u5e38\u589e\u6b96\u7684\u6076\u6027\u75be\u75c5\u3002\u5bf9\u4e8e\u521d\u6cbb\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\uff0c\u5e38\u7528\u7684\u4e00\u7ebf\u6cbb\u7597\u836f\u7269\u5305\u62ec\u86cb\u767d\u9176\u4f53\u6291\u5236\u5242\u3001\u514d\u75ab\u8c03\u8282\u7c7b\u836f\u7269\u53ca\u70f7\u5316\u5242\u7c7b\u836f\u7269\u3002\u5bf9\u4e8e\u5927\u591a\u6570\u7684\u60a3\u8005\uff0c\u5e38\u7528\u7684\u4e00\u7ebf\u6cbb\u7597\u53ef\u4ee5\u4f7f\u60a3\u8005\u7684\u75c5\u60c5\u7a33\u5b9a3-5\u5e74\uff0c\u4f46\u4e5f\u6709\u5c11\u90e8\u5206\u60a3\u8005\u5728\u521d\u6cbb\u65f6\u8868\u73b0\u4e3a\u539f\u53d1\u8010\u836f\uff0c\u75c5\u60c5\u4e0d\u80fd\u5f97\u5230\u6709\u6548\u63a7\u5236\u3002\u5bf9\u4e8e\u6cbb\u7597\u6709\u6548\u7684\u5927\u591a\u6570\u521d\u6cbb\u60a3\u8005\uff0c\u5728\u7ecf\u8fc7\u75be\u75c5\u7a33\u5b9a\u671f\u540e\u4e5f\u4f1a\u4e0d\u53ef\u907f\u514d\u7684\u8fdb\u5165\u590d\u53d1\u3001\u96be\u6cbb\u9636\u6bb5\u3002\u56e0\u6b64\uff0c\u590d\u53d1\/\u96be\u6cbb\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u4ecd\u5b58\u5728\u672a\u6ee1\u8db3\u7684\u9700\u6c42\u3002<\/p>\n<p><b>\u5173\u4e8eIBI326 (BCMA CAR-T)<\/b><\/p>\n<p>IBI326\u662f\u7531\u4fe1\u8fbe\u751f\u7269\u548c\u9a6f\u9e7f\u533b\u7597\u5236\u836f\u8054\u5408\u5f00\u53d1\u7684\u4e00\u79cd\u521b\u65b0\u4ea7\u54c1\u3002\u672c\u4ea7\u54c1\u4ee5\u6162\u75c5\u6bd2\u4e3a\u57fa\u56e0\u8f7d\u4f53\u8f6c\u67d3\u81ea\u4f53T\u7ec6\u80de\uff0cCAR\u5305\u542b\u5168\u4eba\u6e90scFv\u3001CD8a \u94f0\u94fe\u548c\u8de8\u819c\u30014-1BB\u5171\u523a\u6fc0\u548cCD3\u03b6\u6fc0\u6d3b\u7ed3\u6784\u57df\u3002\u57fa\u4e8e\u4e25\u683c\u7684\u7b5b\u9009\uff0c\u901a\u8fc7\u5168\u9762\u7684\u4f53\u5185\u5916\u529f\u80fd\u8bc4\u4ef7\uff0cIBI326 CAR-T\u4ea7\u54c1\u5177\u6709\u5f3a\u6709\u529b\u548c\u5feb\u901f\u7684\u7597\u6548\uff0c\u5e76\u6709\u7a81\u51fa\u7684\u6301\u4e45\u6027\u30022021\u5e742\u6708\uff0cIBI326\u83b7\u56fd\u5bb6\u836f\u76d1\u5c40\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\u8ba4\u5b9a\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3002<\/p>\n<p><b>\u5173\u4e8e\u4fe1\u8fbe\u751f\u7269<\/b><\/p>\n<p>\u201c\u59cb\u4e8e\u4fe1\uff0c\u8fbe\u4e8e\u884c\u201d\uff0c\u5f00\u53d1\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8d28\u91cf\u751f\u7269\u836f\uff0c\u662f\u4fe1\u8fbe\u751f\u7269\u7684\u7406\u60f3\u548c\u76ee\u6807\u3002\u4fe1\u8fbe\u751f\u7269\u6210\u7acb\u4e8e2011\u5e74\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8c22\u75be\u75c5\u7b49\u91cd\u5927\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\u30022018\u5e7410\u670831\u65e5\uff0c\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u5728\u9999\u6e2f\u8054\u5408\u4ea4\u6613\u6240\u6709\u9650\u516c\u53f8\u4e3b\u677f\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a01801\u3002<\/p>\n<p>\u81ea\u6210\u7acb\u4ee5\u6765\uff0c\u516c\u53f8\u51ed\u501f\u521b\u65b0\u6210\u679c\u548c\u56fd\u9645\u5316\u7684\u8fd0\u8425\u6a21\u5f0f\u5728\u4f17\u591a\u751f\u7269\u5236\u836f\u516c\u53f8\u4e2d\u8131\u9896\u800c\u51fa\u3002\u5efa\u7acb\u8d77\u4e86\u4e00\u6761\u5305\u62ec24\u4e2a\u65b0\u836f\u54c1\u79cd\u7684\u4ea7\u54c1\u94fe\uff0c\u8986\u76d6\u80bf\u7624\u3001\u4ee3\u8c22\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u7b49\u591a\u4e2a\u75be\u75c5\u9886\u57df\uff0c\u5176\u4e2d6\u4e2a\u54c1\u79cd\u5165\u9009\u56fd\u5bb6\u201c\u91cd\u5927\u65b0\u836f\u521b\u5236\u201d\u4e13\u9879\u3002\u516c\u53f8\u5df2\u67094\u4e2a\u4ea7\u54c1\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u4f2f\u8212<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aTYVYT<sup>&reg;<\/sup>\uff1b\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u6538\u540c<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aBYVASDA<sup>&reg;<\/sup>\uff1b\u963f\u8fbe\u6728\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u82cf\u7acb\u4fe1<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aSULINNO<sup>&reg;<\/sup>\uff1b\u5229\u59a5\u6614\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5546\u54c1\u540d\uff1a\u8fbe\u4f2f\u534e<sup>&reg;<\/sup>\uff0c\u82f1\u6587\u5546\u6807\uff1aHALPRYZA<sup>&reg;<\/sup>\uff09\u83b7\u5f97NMPA\u6279\u51c6\u4e0a\u5e02, 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\u764c\u75c7\u4e2d\u5fc3\u548c\u97e9\u56fdHanmi\u7b49\u56fd\u9645\u5408\u4f5c\u65b9\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u3002\u4fe1\u8fbe\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u56fd\u751f\u7269\u5236\u836f\u4ea7\u4e1a\u7684\u53d1\u5c55\u6c34\u5e73\uff0c\u4ee5\u6ee1\u8db3\u767e\u59d3\u7528\u836f\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5bf9\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u613f\u671b\u7684\u8ffd\u6c42\u3002\u8be6\u60c5\u8bf7\u8bbf\u95ee\u516c\u53f8\u7f51\u7ad9\uff1a<a target=\"_blank\" href=\"http:\/\/www.innoventbio.com\/\" rel=\"nofollow 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myeloma: room for more?\u300b(DOI 10.1182\/blood.2021010833)\u3002 \u4fe1\u8fbe\u751f\u7269\u4e34\u5e8a\u5f00\u53d1\u9ad8\u7ea7\u526f\u603b\u88c1\u5468\u8f89\u535a\u58eb\u8868\u793a\uff1a\u201c\u5f88\u9ad8\u5174\u770b\u5230IBI326\uff08\u9a6f\u9e7f\u533b\u7597\u7814\u53d1\u4ee3\u53f7CT103A\uff09\u4f18\u5f02\u7684\u4e34\u5e8a\u6570\u636e\u83b7\u5f97\u4e86\u6b27\u6d32\u8840\u6db2\u5b66\u5e74\u4f1a\u7684\u5927\u529b\u80af\u5b9a\u3002\u5c24\u5176\u5bf9\u4e8e\u65e2\u5f80\u975e\u4eba\u6e90CART\u6cbb\u7597\u5931\u8d25\u53d7\u8bd5\u8005\u4ecd\u6709\u8f83\u597d\u7684\u4e34\u5e8a\u83b7\u76ca\uff0c\u4e3a\u590d\u53d1\/\u96be\u6cbb\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u63d0\u4f9b\u4e86\u66f4\u4f18\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u671f\u5f85\u8be5\u6b3e\u7ec6\u80de\u7597\u6cd5\u7684\u65e9\u65e5\u4e0a\u5e02\uff0c\u9020\u798f\u60a3\u8005\u3002\u201d&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2021060807000033356\">Read 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