{"id":33202,"date":"2021-06-07T09:00:00","date_gmt":"2021-06-07T02:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021060709000033202"},"modified":"2021-06-07T21:37:47","modified_gmt":"2021-06-07T13:37:47","slug":"%e5%8e%9f%e5%90%af%e7%94%9f%e7%89%a9%e9%a6%96%e4%b8%aa%e9%9d%b6%e5%90%91%e8%82%9d%e7%99%8ccar-t-%e7%bb%86%e8%83%9e%e4%ba%a7%e5%93%81%e4%ba%ae%e7%9b%b8asco%ef%bc%8c%e4%b8%b4%e5%ba%8a%e6%95%b0%e6%8d%ae","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021060709000033202","title":{"rendered":"\u539f\u542f\u751f\u7269\u9996\u4e2a\u9776\u5411\u809d\u764cCAR-T \u7ec6\u80de\u4ea7\u54c1\u4eae\u76f8ASCO\uff0c\u4e34\u5e8a\u6570\u636e\u4ee4\u4eba\u632f\u594b"},"content":{"rendered":"<p><p>\u4e0a\u6d772021\u5e746\u67087\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u7f8e\u56fd\u4e1c\u90e8\u65f6\u95f42021\u5e746\u67084\u65e5\uff0c\u539f\u542f\u751f\u7269\u79d1\u6280\uff08\u4e0a\u6d77\uff09\u6709\u9650\u8d23\u4efb\u516c\u53f8\uff08\u7b80\u79f0\u201c\u539f\u542f\u751f\u7269\u201d\uff09&nbsp;\u4e0e\u6d59\u6c5f\u5927\u5b66\u9644\u5c5e\u4e3d\u6c34\u5e02\u4e2d\u5fc3\u533b\u9662\u548c\u4e0a\u6d77\u957f\u5f81\u533b\u9662\u57282021\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a\u9996\u6b21\u516c\u5e03\u5176\u8bc4\u4f30\u9776\u5411GPC3\u7684CAR-T\u836f\u7269\uff08Ori-CAR-001\uff09\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u809d\u7ec6\u80de\u764c\uff08hepatocellular carcinoma\uff0cHCC\uff09\u7684\u6700\u65b0\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff08Abstract ID: 4095\uff09\u3002\u8be5\u7814\u7a76\u7684\u521d\u6b65\u6570\u636e\u663e\u793a\uff0cOri-CAR-001\u5728GPC3\u9633\u6027\u590d\u53d1\/\u96be\u6cbb\u6027\u60a3\u8005\u4e2d\u8868\u73b0\u51fa\u826f\u597d\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/p>\n<p><b>\u7ec6\u80de\u7597\u6cd5\u5728\u5b9e\u4f53\u7624\u9886\u57df\u7684\u91cd\u5927\u7a81\u7834<\/b><\/p>\n<p>\u622a\u81f32021\u5e743\u670810\u65e5\uff0c\u672c\u7814\u7a76\u5171\u7eb3\u516511\u4f8b\u63a5\u53d7\u7ec6\u80de\u8f93\u6ce8\u7684\u590d\u53d1\u53d7\u8bd5\u8005\uff0c\u5747\u4e3a\u5316\u7597\u3001TACE\u4ee5\u53ca\u9776\u5411\u836f\u7269\u6cbb\u7597\u65e0\u6548\u7684\u665a\u671f\u809d\u764c\u60a3\u8005\u3002\u6309\u7167\u5df4\u585e\u7f57\u90a3\u5206\u671f\u6807\u51c6**\u8fdb\u884c\u8bc4\u4f30\uff0c\u96641\u4f8b\u4e3aB\u671f\uff08\u4e2d\u671f\uff09\uff0c\u5176\u4f5910\u4f8b\u5168\u90e8\u4e3aC\u671f\uff08\u665a\u671f\uff09\u3002\u6240\u6709\u53d7\u8bd5\u8005\u90fd\u6709\u591a\u5904\u7684\u8f6c\u79fb\u75c5\u7076\uff0c\u5176\u4e2d6\u4f8b\uff0854%\uff09\u53d7\u8bd5\u8005\u6709\u80ba\u90e8\u7b49\u8fdc\u7aef\u8f6c\u79fb\u3002\u96642\u4f8b\u53d7\u8bd5\u8005\u672a\u63a5\u53d7\u8bc4\u4f30\u9000\u7ec4\u5916\uff0c\u5728&nbsp;9\u4f8b\u53ef\u8bc4\u4ef7\u7684\u60a3\u8005\u4e2d\uff0c4\u4f8b\u83b7\u5f97\u90e8\u5206\u7f13\u89e3\uff08PR\uff09, 3\u4f8b\u83b7\u5f97\u75be\u75c5\u7a33\u5b9a\uff08SD\uff09\uff0c2\u4f8b\u83b7\u5f97\u75be\u75c5\u8fdb\u5c55\uff08PD\uff09\u3002\u6cbb\u7597\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\u8fbe44.44%\uff0c\u75be\u75c5\u63a7\u5236\u7387\u8fbe77.78%\u3002<\/p>\n<p>\u5176\u4e2d\uff0c\u53d7\u8bd5\u8005007\u7684PR\u7f13\u89e3\u65f6\u95f4\u8d85\u8fc76\u4e2a\u6708\uff0c\u80bf\u7624\u4f53\u79ef\u51cf\u5c11\u8d85\u8fc780%\u3002\u622a\u6b62\u65e5\u524d\u8be5\u60a3\u8005\u7684\u7f13\u89e3\u5468\u671f\u5df2\u8d85\u8fc78\u4e2a\u6708\uff0c\u4ecd\u5728\u6301\u7eed\u968f\u8bbf\u4e2d\u3002\u53e6\u4e00\u540d\u7597\u6548\u663e\u8457\u7684\u53d7\u8bd5\u8005012\u662f\u4e00\u4f4d\u5f25\u6f2b\u6d78\u6da6\u6027\u975e\u5e38\u665a\u671f\u7684\u809d\u764c\u60a3\u8005\uff0c\u66fe\u63a5\u53d7\u8fc7&nbsp;12\u6b21\u4ee5\u4e0a\u7684TACE\u6cbb\u7597\uff0c\u5728\u653e\u7597\u53ca\u9776\u5411\u6cbb\u7597\u65e0\u6548\u540e\u52a0\u5165\u672c\u7814\u7a76\u3002\u56de\u8f9328\u5929\u540eMRI\u7ed3\u679c\u663e\u793a\u6700\u5927\u80bf\u7624\u76f4\u5f84\u4ece133mm\u51cf\u5c11\u81f39mm\uff0c\u7f29\u5c0f\u8d85\u8fc790%\u3002\u76ee\u524d\uff0c\u8be5\u53d7\u8bd5\u8005\u5728<span id=\"spanHghlt408a\">\u56de\u8f933\u4e2a\u6708\u540e\u8bc4\u4f30<\/span>\uff0cMRI\u626b\u63cf\u7ed3\u679c\u663e\u793a\u6b64\u80bf\u7624\u51e0\u4e4e\u6d88\u5931\u3002\u76f8\u5e94\u5730\uff0c\u56de\u8f9328\u5929\u540e\u5176AFP \uff08\u7532\u80ce\u86cb\u767d\uff0c\u8bca\u65ad\u539f\u53d1\u6027\u809d\u764c\u7279\u5f02\u6027\u7684\u80bf\u7624\u6807\u5fd7\u7269\uff09\u6c34\u5e73\u4ece&gt;80000\u964d\u81f31148.9ng\/ml\uff0c<span id=\"spanHghlt408a\">\u56de\u8f933\u4e2a\u6708\u540e<\/span>\u964d\u81f3746.7ng\/ml \uff08\u5176\u6b63\u5e38\u503c\u662f\u57280-40ng\/ml\u4ee5\u5185\uff09\uff0c\u5c55\u793a\u4e86Ori-CAR-001\u5728\u665a\u671f\u809d\u764c\u6cbb\u7597\u7684\u663e\u8457\u6709\u6548\u6027\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder9392\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/1526883\/image1.html\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/image1-673.jpg\" title=\"\" alt=\"\" \/><\/a><br \/><span><\/span><\/p>\n<\/p><\/div>\n<p>&nbsp;<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder8072\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/1526884\/image2.html\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/image2-569.jpg\" title=\"\" alt=\"\" \/><\/a><br \/><span><\/span><\/p>\n<\/p><\/div>\n<p><b>\u5b89\u5168\u6027\u826f\u597d&nbsp;<\/b><\/p>\n<p>\u5728\u5df2\u56de\u8f93\u768411\u4f8b\u60a3\u8005\u4e2d\uff0cOri-CAR-001\u663e\u793a\u51fa\u4e86\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u30029\u4f8b\u60a3\u8005\u89c2\u5bdf\u5230\u4e86\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff08CRS\uff09\uff0c\u5176\u4e2d7\u4f8b\u53d1\u751f1-2\u7ea7CRS\uff0c2\u4f8b\u7ecf\u9759\u8109\u56de\u8f93\u51fa\u73b04\u7ea7CRS\uff0c\u7ed9\u4e88\u7c7b\u56fa\u9187\u6fc0\u7d20\u548c\u6258\u73e0\u5355\u6297\u6cbb\u7597\u540e\u6062\u590d\u6b63\u5e38\u3002\u6ca1\u6709\u89c2\u5bdf\u5230\u795e\u7ecf\u6bd2\u6027\u3002<\/p>\n<p><span>\u5bf9\u4e8e<\/span><span>Ori-CAR-001<\/span><span>\u6cbb\u7597\u665a\u671f\u96be\u6cbb<\/span><span>\/<\/span><span>\u590d\u53d1\u578b\u809d\u764c\u5728\u63a2\u7d22\u6027\u4e34\u5e8a\u7814\u7a76\u4e2d\u83b7\u5f97\u7684\u7ed3\u679c\uff0c\u8be5\u4e34\u5e8a\u9879\u76ee\u7684<\/span><span>PI<\/span><span>\u4e4b\u4e00\u7684\u56fd\u5bb6\u91cd\u70b9\u7814\u53d1\u8ba1\u5212\u9996\u5e2d\u79d1\u5b66\u5bb6<\/span><span>,<\/span><span>&nbsp;<\/span><span>\u6d59\u6c5f\u7701\u5f71\u50cf\u8bca\u65ad\u4e0e\u4ecb\u5165\u5fae\u521b\u7814\u7a76\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u4e3b\u4efb<\/span><span>\u7eaa\u5efa\u677e\u6559\u6388\u8868\u793a\uff1a<\/span><span>\u201c<\/span><span>\u590d\u53d1<\/span><span>\/<\/span><span>\u96be\u6cbb\u809d\u7ec6\u80de\u764c\u76ee\u524d\u6ca1\u6709\u6709\u6548\u6cbb\u7597\u624b\u6bb5\uff0c\u7ec6\u80de\u6cbb\u7597\u5b9e\u4f53\u7624\u7531\u4e8e\u53d7\u5230\u80bf\u7624\u5fae\u73af\u5883\u7b49\u56e0\u7d20\u5f71\u54cd\u96be\u4ee5\u7a81\u7834\u3002\u800c\u539f\u542f\u751f\u7269\u7684<\/span><span>Ori-CAR-001<\/span><span>\u7ec6\u80de\u6cbb\u7597\u590d\u53d1<\/span><span>\/<\/span><span>\u96be\u6cbb\u6027\u809d\u7ec6\u80de\u764c\u5ba2\u89c2\u7f13\u89e3\u7387\u8fbe\u5230\u4e86<\/span><span>44%<\/span><span>\uff0c\u75be\u75c5\u63a7\u5236\u7387\u8fbe\u5230\u4e86<\/span><span>77%<\/span><span>\uff0c\u662f\u76ee\u524d\u5df2\u4e0a\u5e02\u836f\u7269\u65e0\u6cd5\u4f01\u53ca\u7684\u517c\u5177\u5b89\u5168\u53ef\u63a7\u548c\u826f\u597d\u6297\u80bf\u7624\u6d3b\u6027\u7684\u6548\u679c\u3002\u57fa\u4e8e\u524d\u671f\u826f\u597d\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u6570\u636e\uff0c<\/span><span>Ori-CAR-001<\/span><span>\u7ec6\u80de\u836f\u7269\u6709\u671b\u6210\u4e3a\u665a\u671f\u809d\u7ec6\u80de\u764c\u60a3\u8005\u65b0\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u8fd9\u8ba9\u6211\u4eec\u5bf9\u5176\u672a\u6765\u7684\u7814\u7a76\u524d\u666f\u5145\u6ee1\u4fe1\u5fc3\uff0c\u4e5f\u5bf9\u4e2d\u56fd\u7684\u521b\u65b0\u836f\u611f\u5230\u81ea\u8c6a\u3002<\/span><span>\u201d<\/span><\/p>\n<p><span><\/span>\u539f\u542f\u751f\u7269\u8054\u5408\u521b\u59cb\u4eba\u3001\u9996\u5e2d\u79d1\u5b66\u5b98\u4f55\u6653\u6587\u535a\u58eb\u8868\u793a\uff1a\u201c\u80bf\u7624\u514d\u75ab\u7ec6\u80de\u6cbb\u7597\u5728\u8840\u6db2\u80bf\u7624\u4e0a\u5df2\u7ecf\u6709\u975e\u5e38\u597d\u7684\u6cbb\u7597\u6548\u679c\uff0c\u672a\u6765\u5728\u5b9e\u4f53\u7624\u6cbb\u7597\u8fd9\u4e2a\u66f4\u5927\u7684\u4e34\u5e8a\u9700\u6c42\u4e0a\uff0c\u539f\u542f\u751f\u7269\u5c06\u4e0d\u65ad\u63a2\u7d22\uff0c\u5e0c\u671b\u80fd\u4e3a\u4f17\u591a\u7684\u665a\u671f\u75c5\u4eba\u548c\u4e34\u5e8a\u533b\u751f\u5e26\u6765\u66f4\u6709\u6548\u7684\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\u65b9\u6848<span id=\"spanHghlt177b\">\u3002\u201d<\/span><\/p>\n<p><span><\/span><\/p>\n<div>\n<table cellspacing=\"0\" cellpadding=\"0\" border=\"0\" class=\"prntblns\">\n<tbody>\n<tr>\n<td class=\"prnsbt1 prnsbr1 prnvab prnsbb1 prnpl6 prnsbl1 prnpr6\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><span id=\"spanHghlt8827\" class=\"prnews_span\">**Barcelona Clinic Liver Cancer\uff0cBCLC\uff0c\u6b27\u6d32\u809d\u75c5\u534f\u4f1a\u5236\u5b9a\u7684\u809d\u764c\u4e34\u5e8a\u5206\u671f\u7cfb\u7edf\uff0c\u5e2e\u52a9\u8bc4\u4f30\u75c5\u4eba\u7684\u60a3\u75c5\u60c5\u51b5\u63d0\u4f9b\u51c6\u786e\u6cbb\u7597\u65b9\u6848\u548c\u9884\u6d4b\u60a3\u8005\u9884\u540e\uff0c\u4e3b\u8981\u5206\u4e3a0\u3001A\u3001A1\u3001A2\u3001A3\u3001A4\u3001B\u3001C\u3001D\u671f\u3002<\/span><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<\/p>\n<p><b>\u5173\u4e8eOri-CAR-001<\/b><\/p>\n<p><span>\u201cOri-CAR-001<\/span><span>\u7ec6\u80de\u662f\u9776\u5411<\/span><span>GPC3<\/span><span>\u7684\u9ad8\u5e72\u6027\u5d4c\u5408\u6297\u539f\u53d7\u4f53<\/span><span>T<\/span><span>\u7ec6\u80de\uff0c\u62df\u7528\u4e8e\u6cbb\u7597\u96be\u6cbb\u6027<\/span><span>\/<\/span><span>\u590d\u53d1\u6027\u7684\u809d\u7ec6\u80de\u764c\uff08<\/span><span>HCC<\/span><span>\uff09\u3002<\/span><span>Ori-CAR-001<\/span><span>\u91c7\u7528\u7684<\/span><span>&nbsp;GPC3 CAR<\/span><span>\u7ed3\u6784\u662f\u7531\u6297<\/span><span>GPC3<\/span><span>\u7684<\/span><span>scFv<\/span><span>\u5f62\u5f0f\u4eba\u6e90\u5316\u6297\u4f53\u3001<\/span><span>CD8&nbsp;<\/span><span>\u7ede\u94fe\u533a\u3001\u8de8\u819c\u533a\u3001<\/span><span>4-1BB&nbsp;<\/span><span>\u5171\u523a\u6fc0\u57df\u3001<\/span><span>CD3z<\/span><span>\u80de\u5185\u6fc0\u6d3b\u57df\u3001\u4ee5\u53ca\u901a\u8fc7<\/span><span>T2A<\/span><span>\u540c\u65f6\u8868\u8fbe\u7684<\/span><span>Ori2<\/span><span>\u65b0\u5143\u4ef6\u6784\u6210\uff0c\u7ecf\u6162\u75c5\u6bd2\u611f\u67d3<\/span><span>T<\/span><span>\u7ec6\u80de\u540e\u5728\u9002\u4e8e\u8bb0\u5fc6\u6027<\/span><span>T<\/span><span>\u7ec6\u80de\u7684\u57f9\u517b\u5de5\u827a\u4e0b\u6269\u589e\u5236\u6210\u3002\u4e0e\u4f20\u7edf\u7684<\/span><span>CAR-T<\/span><span>\u7ec6\u80de\u6bd4\u8f83\uff0c<\/span><span>Ori-CAR-001<\/span><span>\u660e\u663e\u5177\u6709\u66f4\u9ad8\u7684\u8bb0\u5fc6\u5e72\u7ec6\u80de\u6bd4\u4f8b\uff0c\u62b5\u6297\u514d\u75ab\u8d1f\u73af\u5883\uff0c\u53ef\u663e\u8457\u63d0\u9ad8<\/span><span>CAR-T<\/span><span>\u7ec6\u80de\u7684\u6269\u589e\u548c\u7ef4\u6301\uff0c\u4ece\u800c\u63d0\u9ad8\u5176\u6297\u80bf\u7624\u529f\u6548\u3002\u201d<\/span><\/p>\n<p>\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u672c\u6b21\u4f1a\u8bae\u9664\u4e86\u5728\u7814\u7a76\u4e2d\u521d\u6b65\u8bc1\u5b9eCAR-T\u6cbb\u7597HCC\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u539f\u542f\u751f\u7269\u4e0e\u7814\u7a76\u8005\u4eec\u540c\u65f6\u8fdb\u884c\u4e86\u8f6c\u5316\u533b\u5b66\u7684\u76f8\u5173\u7814\u7a76\uff0c\u5bf9\u7ed9\u836f\u65b9\u5f0f\u3001\u7ed9\u836f\u5242\u91cf\u3001PK\/PD\uff08\u836f\u4ee3\u52a8\u529b\u5b66\/\u836f\u6548\u52a8\u529b\u5b66\uff09\u3001\u751f\u7269\u6807\u5fd7\u7269\u8fdb\u884c\u63a2\u7d22\uff0c\u63a8\u8fdb\u4e86\u7ec6\u80de\u6cbb\u7597\u5b9e\u4f53\u80bf\u7624\u5e94\u7528\u548c\u53d1\u5c55\u3002<\/p>\n<p>\u76ee\u524d\uff0c\u539f\u542f\u751f\u7269\u5c06\u5728\u5df2\u6709\u7684\u6570\u636e\u57fa\u7840\u4e0a\u8fdb\u4e00\u6b65\u63a2\u7d22\u76f8\u5173\u4e34\u5e8a\u7814\u7a76\uff0c\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NPMA\uff09\u7684\u65b0\u836f\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\uff08IND\uff09\u7533\u8bf7\u6b63\u5728\u540c\u6b65\u8fdb\u884c\u3002<\/p>\n<p><b>\u5173\u4e8e\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u534f\u4f1a<\/b><\/p>\n<p>\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a&nbsp;(ASCO) \u662f\u5168\u7403\u9886\u5148\u7684\u80bf\u7624\u4e13\u4e1a\u5b66\u672f\u7ec4\u7ec7\uff0c\u6709\u6765\u81ea100 \u591a\u4e2a\u56fd\u5bb6\u8d85\u8fc740000\u540d\u4f1a\u5458\uff0c\u5176\u65e8\u662f\u9884\u9632\u764c\u75c7\u53ca\u6539\u5584\u764c\u75c7\u670d\u52a1\uff0c\u4fc3\u8fdb\u7814\u7a76\u6210\u679c\u8f6c\u5316\u5230\u4e34\u5e8a\u5e94\u7528\u3002\u4e00\u5e74\u4e00\u5ea6\u7684ASCO\u5e74\u4f1a\u6c47\u805a\u4e86\u5168\u7403\u4e34\u5e8a\u80bf\u7624\u5b66\u7814\u7a76\u7684\u7cbe\u82f1\uff0c\u88ab\u516c\u8ba4\u4e3a\u5168\u7403\u6700\u91cd\u8981\u7684\u80bf\u7624\u5b66\u672f\u4f1a\u8bae\u3002<\/p>\n<p><b>\u5173\u4e8e\u539f\u542f\u751f\u7269&nbsp;<\/b><\/p>\n<p>\u539f\u542f\u751f\u7269\u79d1\u6280\uff08\u4e0a\u6d77\uff09\u6709\u9650\u8d23\u4efb\u516c\u53f8\uff08\u539f\u79f0\u201c\u4e0a\u6d77\u539f\u80fd\u7ec6\u80de\u533b\u5b66\u6280\u672f\u516c\u53f8\u201d\u81ea2021\u5e745\u670825\u65e5\u8d77\u6b63\u5f0f\u66f4\u540d\uff09\u6210\u7acb\u4e8e2015\u5e74\uff0c\u57282019\u5e74\u5e95\u83b7\u5f97\u542f\u660e\u521b\u6295\u8fd1\u4ebf\u5143\u7684Pre-A\u8f6e\u72ec\u5bb6\u6295\u8d44\uff0c2020\u5e74\u5e95\u5b8c\u6210\u8d85\u8fc72\u4ebf\u5143\u4eba\u6c11\u5e01\u7684A\u8f6e\u878d\u8d44\u3002\u5728\u542f\u660e\u521b\u6295\u652f\u6301\u4e0b\uff0c\u539f\u542f\u751f\u7269\u4f5c\u4e3a\u539f\u80fd\u7ec6\u80de\u96c6\u56e2\u751f\u7269\u521b\u65b0\u836f\u7814\u53d1\u8d44\u4ea7\u5206\u62c6\u72ec\u7acb\uff0c\u672a\u6765\u5c06\u805a\u7126\u4e8e\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u9886\u57df\u7684\u65b0\u4ea7\u54c1\u5f00\u53d1<span id=\"spanHghlt65ac\">\u3002<\/span><\/p>\n<p>\u539f\u542f\u751f\u7269\u7acb\u8db3\u4e8e\u81ea\u4e3b\u521b\u65b0\uff0c\u6295\u5165\u5de8\u8d44\u6784\u5efa\u4e86\u534f\u540c\u589e\u6548\u7684\u56db\u4e2a\u521b\u65b0\u578b\u4ea7\u54c1\u7814\u53d1\u6280\u672f\u5e73\u53f0\uff1aOri&#x2122;Ab\u6297\u4f53\u5f00\u53d1\u4e0e\u4f18\u5316\u6280\u672f\u5e73\u53f0\u3001Ori&#x2122;CAR\u9ad8\u8bb0\u5fc6\u6027CAR-T\u7ed3\u6784\u6280\u672f\u5e73\u53f0\u3001Ori&#x2122;TIL\u7ec6\u80de\u9ad8\u6548\u6269\u589e\u57f9\u517b\u6280\u672f\u5e73\u53f0\u548cOri&#x2122;UCAR\u901a\u7528\u578bCAR-T\u6280\u672f\u5e73\u53f0\u3002<\/p>\n<p><b><u>\u5173\u4e8e<\/u><u>Ori&#x2122;Ab\u2014<\/u><u>\u6297\u4f53\u53d1\u73b0\u6280\u672f\u5e73<\/u><u>\u53f0<\/u><\/b><\/p>\n<p>\u5efa\u670910<sup>11<\/sup>\u5168\u4eba\u6e90\u6297\u4f53\u566c\u83cc\u4f53\u5c55\u793a\u5e93\u548c10<sup>12<\/sup>\u7eb3\u7c73\u6297\u4f53\u5e93\u53ca\u6297\u4f53\u5de5\u7a0b\u7684\u6280\u672f\u5e73\u53f0\uff0c\u5df2\u4ea7\u751f\u4e00\u7cfb\u5217\u81ea\u4e3b\u521b\u65b0\u4e14\u6027\u80fd\u4f18\u8d8a\u7684\u6297\u4f53\u4faf\u9009\u836f\u7269\u53caCAR-T\u7ec6\u80de\u9776\u70b9\u6297\u4f53\u3002<\/p>\n<p><b><u>\u5173\u4e8e<\/u><u>Ori&#x2122;CAR<\/u><u>\u6280\u672f\u5e73<\/u><u>\u53f0<\/u><\/b><\/p>\n<p>\u5728\u65b0\u9896\u4e14\u4e13\u6709\u7684CAR\u7ed3\u6784\u5185\u63d2\u5165\u4e86\u72ec\u7279\u7684\u4fe1\u53f7\u6fc0\u6d3b\u57df\uff0c\u6210\u500d\u63d0\u5347\u8bb0\u5fc6\u6027\u514d\u75ab\u7ec6\u80de\u6269\u589e\u6548\u7387\uff0c\u6709\u6548\u62b5\u6297\u5b9e\u4f53\u80bf\u7624\u7684\u514d\u75ab\u8d1f\u73af\u5883\uff0c\u589e\u5f3aCAR-T\u7684\u529f\u6548\u548c\u6301\u4e45\u6027\uff0c\u9ad8\u6548\u6291\u5236\u80bf\u7624\u548c\u9884\u9632\u590d\u53d1\u3002<\/p>\n<p><b><u>\u5173\u4e8e<\/u><u>Ori&#x2122;TIL\u2014<\/u><u>\u7ec6\u80de\u9ad8\u6548\u6269\u589e\u57f9\u517b\u6280\u672f\u5e73\u53f0<\/u><u>&nbsp;<\/u><\/b><\/p>\n<p>\u9ad8\u500d\u7387\u63d0\u5347TIL\u7ec6\u80de\u6269\u589e\u6570\u91cf\uff0c\u8d28\u91cf\u5c5e\u6027\u548c\u5de5\u827a\u53c2\u6570\u7a81\u7834\u884c\u4e1a\u74f6\u9888\uff0c\u6709\u6548\u786e\u4fddTIL\u7597\u6cd5\u7684\u4e34\u5e8a\u6548\u679c\u548c\u5b89\u5168\u4fdd\u969c\uff0c\u5e74\u8f7b\u6001TIL\u7ec6\u80de\u589e\u5f3a\u80bf\u7624\u6740\u4f24\u6d3b\u6027\u3002<\/p>\n<p><b><u>\u5173\u4e8e<\/u><u>Ori&#x2122;UCAR<\/u><u>\u6280\u672f\u5e73\u53f0<\/u><u>&nbsp;<\/u><\/b><\/p>\n<p>\u9ad8\u6548\u534f\u540c\u6297\u4f53\u6280\u672f\u3001Ori\u6280\u672f\u548c\u57fa\u56e0\u7f16\u8f91\u548c\u7ec6\u80de\u5206\u5316\u6280\u672f\u7b49\u5e73\u53f0\u4f18\u52bf\uff0c\u4ee5\u5b9e\u73b0\u672a\u6765CAR-T\u4ea7\u54c1\u7684\u901a\u7528\u6027\u53ca\u4fbf\u6377\u6027\uff0c\u540c\u65f6\u6709\u6548\u964d\u4f4e\u4f7f\u7528\u6210\u672c\u3002<\/p>\n<p>&nbsp;<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder0\">  <\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u4e0a\u6d772021\u5e746\u67087\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u7f8e\u56fd\u4e1c\u90e8\u65f6\u95f42021\u5e746\u67084\u65e5\uff0c\u539f\u542f\u751f\u7269\u79d1\u6280\uff08\u4e0a\u6d77\uff09\u6709\u9650\u8d23\u4efb\u516c\u53f8\uff08\u7b80\u79f0\u201c\u539f\u542f\u751f\u7269\u201d\uff09&nbsp;\u4e0e\u6d59\u6c5f\u5927\u5b66\u9644\u5c5e\u4e3d\u6c34\u5e02\u4e2d\u5fc3\u533b\u9662\u548c\u4e0a\u6d77\u957f\u5f81\u533b\u9662\u57282021\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a\u9996\u6b21\u516c\u5e03\u5176\u8bc4\u4f30\u9776\u5411GPC3\u7684CAR-T\u836f\u7269\uff08Ori-CAR-001\uff09\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u809d\u7ec6\u80de\u764c\uff08hepatocellular carcinoma\uff0cHCC\uff09\u7684\u6700\u65b0\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff08Abstract ID: 4095\uff09\u3002\u8be5\u7814\u7a76\u7684\u521d\u6b65\u6570\u636e\u663e\u793a\uff0cOri-CAR-001\u5728GPC3\u9633\u6027\u590d\u53d1\/\u96be\u6cbb\u6027\u60a3\u8005\u4e2d\u8868\u73b0\u51fa\u826f\u597d\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002 \u7ec6\u80de\u7597\u6cd5\u5728\u5b9e\u4f53\u7624\u9886\u57df\u7684\u91cd\u5927\u7a81\u7834 \u622a\u81f32021\u5e743\u670810\u65e5\uff0c\u672c\u7814\u7a76\u5171\u7eb3\u516511\u4f8b\u63a5\u53d7\u7ec6\u80de\u8f93\u6ce8\u7684\u590d\u53d1\u53d7\u8bd5\u8005\uff0c\u5747\u4e3a\u5316\u7597\u3001TACE\u4ee5\u53ca\u9776\u5411\u836f\u7269\u6cbb\u7597\u65e0\u6548\u7684\u665a\u671f\u809d\u764c\u60a3\u8005\u3002\u6309\u7167\u5df4\u585e\u7f57\u90a3\u5206\u671f\u6807\u51c6**\u8fdb\u884c\u8bc4\u4f30\uff0c\u96641\u4f8b\u4e3aB\u671f\uff08\u4e2d\u671f\uff09\uff0c\u5176\u4f5910\u4f8b\u5168\u90e8\u4e3aC\u671f\uff08\u665a\u671f\uff09\u3002\u6240\u6709\u53d7\u8bd5\u8005\u90fd\u6709\u591a\u5904\u7684\u8f6c\u79fb\u75c5\u7076\uff0c\u5176\u4e2d6\u4f8b\uff0854%\uff09\u53d7\u8bd5\u8005\u6709\u80ba\u90e8\u7b49\u8fdc\u7aef\u8f6c\u79fb\u3002\u96642\u4f8b\u53d7\u8bd5\u8005\u672a\u63a5\u53d7\u8bc4\u4f30\u9000\u7ec4\u5916\uff0c\u5728&nbsp;9\u4f8b\u53ef\u8bc4\u4ef7\u7684\u60a3\u8005\u4e2d\uff0c4\u4f8b\u83b7\u5f97\u90e8\u5206\u7f13\u89e3\uff08PR\uff09, 3\u4f8b\u83b7\u5f97\u75be\u75c5\u7a33\u5b9a\uff08SD\uff09\uff0c2\u4f8b\u83b7\u5f97\u75be\u75c5\u8fdb\u5c55\uff08PD\uff09\u3002\u6cbb\u7597\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\u8fbe44.44%\uff0c\u75be\u75c5\u63a7\u5236\u7387\u8fbe77.78%\u3002 \u5176\u4e2d\uff0c\u53d7\u8bd5\u8005007\u7684PR\u7f13\u89e3\u65f6\u95f4\u8d85\u8fc76\u4e2a\u6708\uff0c\u80bf\u7624\u4f53\u79ef\u51cf\u5c11\u8d85\u8fc780%\u3002\u622a\u6b62\u65e5\u524d\u8be5\u60a3\u8005\u7684\u7f13\u89e3\u5468\u671f\u5df2\u8d85\u8fc78\u4e2a\u6708\uff0c\u4ecd\u5728\u6301\u7eed\u968f\u8bbf\u4e2d\u3002\u53e6\u4e00\u540d\u7597\u6548\u663e\u8457\u7684\u53d7\u8bd5\u8005012\u662f\u4e00\u4f4d\u5f25\u6f2b\u6d78\u6da6\u6027\u975e\u5e38\u665a\u671f\u7684\u809d\u764c\u60a3\u8005\uff0c\u66fe\u63a5\u53d7\u8fc7&nbsp;12\u6b21\u4ee5\u4e0a\u7684TACE\u6cbb\u7597\uff0c\u5728\u653e\u7597\u53ca\u9776\u5411\u6cbb\u7597\u65e0\u6548\u540e\u52a0\u5165\u672c\u7814\u7a76\u3002\u56de\u8f9328\u5929\u540eMRI\u7ed3\u679c\u663e\u793a\u6700\u5927\u80bf\u7624\u76f4\u5f84\u4ece133mm\u51cf\u5c11\u81f39mm\uff0c\u7f29\u5c0f\u8d85\u8fc790%\u3002\u76ee\u524d\uff0c\u8be5\u53d7\u8bd5\u8005\u5728\u56de\u8f933\u4e2a\u6708\u540e\u8bc4\u4f30\uff0cMRI\u626b\u63cf\u7ed3\u679c\u663e\u793a\u6b64\u80bf\u7624\u51e0\u4e4e\u6d88\u5931\u3002\u76f8\u5e94\u5730\uff0c\u56de\u8f9328\u5929\u540e\u5176AFP \uff08\u7532\u80ce\u86cb\u767d\uff0c\u8bca\u65ad\u539f\u53d1\u6027\u809d\u764c\u7279\u5f02\u6027\u7684\u80bf\u7624\u6807\u5fd7\u7269\uff09\u6c34\u5e73\u4ece&gt;80000\u964d\u81f31148.9ng\/ml\uff0c\u56de\u8f933\u4e2a\u6708\u540e\u964d\u81f3746.7ng\/ml \uff08\u5176\u6b63\u5e38\u503c\u662f\u57280-40ng\/ml\u4ee5\u5185\uff09\uff0c\u5c55\u793a\u4e86Ori-CAR-001\u5728\u665a\u671f\u809d\u764c\u6cbb\u7597\u7684\u663e\u8457\u6709\u6548\u6027\u3002 &nbsp; \u5b89\u5168\u6027\u826f\u597d&nbsp; \u5728\u5df2\u56de\u8f93\u768411\u4f8b\u60a3\u8005\u4e2d\uff0cOri-CAR-001\u663e\u793a\u51fa\u4e86\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u30029\u4f8b\u60a3\u8005\u89c2\u5bdf\u5230\u4e86\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff08CRS\uff09\uff0c\u5176\u4e2d7\u4f8b\u53d1\u751f1-2\u7ea7CRS\uff0c2\u4f8b\u7ecf\u9759\u8109\u56de\u8f93\u51fa\u73b04\u7ea7CRS\uff0c\u7ed9\u4e88\u7c7b\u56fa\u9187\u6fc0\u7d20\u548c\u6258\u73e0\u5355\u6297\u6cbb\u7597\u540e\u6062\u590d\u6b63\u5e38\u3002\u6ca1\u6709\u89c2\u5bdf\u5230\u795e\u7ecf\u6bd2\u6027\u3002 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\u539f\u542f\u751f\u7269\u8054\u5408\u521b\u59cb\u4eba\u3001\u9996\u5e2d\u79d1\u5b66\u5b98\u4f55\u6653\u6587\u535a\u58eb\u8868\u793a\uff1a\u201c\u80bf\u7624\u514d\u75ab\u7ec6\u80de\u6cbb\u7597\u5728\u8840\u6db2\u80bf\u7624\u4e0a\u5df2\u7ecf\u6709\u975e\u5e38\u597d\u7684\u6cbb\u7597\u6548\u679c\uff0c\u672a\u6765\u5728\u5b9e\u4f53\u7624\u6cbb\u7597\u8fd9\u4e2a\u66f4\u5927\u7684\u4e34\u5e8a\u9700\u6c42\u4e0a\uff0c\u539f\u542f\u751f\u7269\u5c06\u4e0d\u65ad\u63a2\u7d22\uff0c\u5e0c\u671b\u80fd\u4e3a\u4f17\u591a\u7684\u665a\u671f\u75c5\u4eba\u548c\u4e34\u5e8a\u533b\u751f\u5e26\u6765\u66f4\u6709\u6548\u7684\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\u65b9\u6848\u3002\u201d **Barcelona Clinic Liver Cancer\uff0cBCLC\uff0c\u6b27\u6d32\u809d\u75c5\u534f\u4f1a\u5236\u5b9a\u7684\u809d\u764c\u4e34\u5e8a\u5206\u671f\u7cfb\u7edf\uff0c\u5e2e\u52a9\u8bc4\u4f30\u75c5\u4eba\u7684\u60a3\u75c5\u60c5\u51b5\u63d0\u4f9b\u51c6\u786e\u6cbb\u7597\u65b9\u6848\u548c\u9884\u6d4b\u60a3\u8005\u9884\u540e\uff0c\u4e3b\u8981\u5206\u4e3a0\u3001A\u3001A1\u3001A2\u3001A3\u3001A4\u3001B\u3001C\u3001D\u671f\u3002 \u5173\u4e8eOri-CAR-001 \u201cOri-CAR-001\u7ec6\u80de\u662f\u9776\u5411GPC3\u7684\u9ad8\u5e72\u6027\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u7ec6\u80de\uff0c\u62df\u7528\u4e8e\u6cbb\u7597\u96be\u6cbb\u6027\/\u590d\u53d1\u6027\u7684\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u3002Ori-CAR-001\u91c7\u7528\u7684&nbsp;GPC3 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\u539f\u542f\u751f\u7269\u79d1\u6280\uff08\u4e0a\u6d77\uff09\u6709\u9650\u8d23\u4efb\u516c\u53f8\uff08\u539f\u79f0\u201c\u4e0a\u6d77\u539f\u80fd\u7ec6\u80de\u533b\u5b66\u6280\u672f\u516c\u53f8\u201d\u81ea2021\u5e745\u670825\u65e5\u8d77\u6b63\u5f0f\u66f4\u540d\uff09\u6210\u7acb\u4e8e2015\u5e74\uff0c\u57282019\u5e74\u5e95\u83b7\u5f97\u542f\u660e\u521b\u6295\u8fd1\u4ebf\u5143\u7684Pre-A\u8f6e\u72ec\u5bb6\u6295\u8d44\uff0c2020\u5e74\u5e95\u5b8c\u6210\u8d85\u8fc72\u4ebf\u5143\u4eba\u6c11\u5e01\u7684A\u8f6e\u878d\u8d44\u3002\u5728\u542f\u660e\u521b\u6295\u652f\u6301\u4e0b\uff0c\u539f\u542f\u751f\u7269\u4f5c\u4e3a\u539f\u80fd\u7ec6\u80de\u96c6\u56e2\u751f\u7269\u521b\u65b0\u836f\u7814\u53d1\u8d44\u4ea7\u5206\u62c6\u72ec\u7acb\uff0c\u672a\u6765\u5c06\u805a\u7126\u4e8e\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u9886\u57df\u7684\u65b0\u4ea7\u54c1\u5f00\u53d1\u3002 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