{"id":33176,"date":"2021-06-07T10:23:00","date_gmt":"2021-06-07T03:23:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021060710230033176"},"modified":"2021-06-07T21:37:00","modified_gmt":"2021-06-07T13:37:00","slug":"%e5%ba%b7%e5%ae%81%e6%9d%b0%e7%91%9ekn046%e8%81%94%e5%90%88%e5%8c%96%e7%96%97%e6%b2%bb%e7%96%97%e6%99%9a%e6%9c%9f%e9%9d%9e%e5%b0%8f%e7%bb%86%e8%83%9e%e8%82%ba%e7%99%8c%e2%85%b1%e6%9c%9f%e4%b8%b4","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021060710230033176","title":{"rendered":"\u5eb7\u5b81\u6770\u745eKN046\u8054\u5408\u5316\u7597\u6cbb\u7597\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u2161\u671f\u4e34\u5e8a\u6570\u636e\u5728ASCO 2021\u4e0a\u516c\u5e03"},"content":{"rendered":"<ul type=\"disc\">\n<li><b>KN046\u8054\u5408\u94c2\u7c7b\u5316\u7597\u5728\u4e00\u7ebf\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e2d\u663e\u793a\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\u548c\u6709\u6548\u6027\uff1b<\/b> 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(NCT04054531)\u662f\u4e00\u9879\u2161\u671f\u3001\u5f00\u653e\u3001\u591a\u4e2d\u5fc3\u4e34\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30KN046\u8054\u5408\u94c2\u7c7b\u5316\u7597\u7528\u4e8e\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u7597\u6548\u3001\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u7ed3\u679c\u663e\u793aKN046\u8010\u53d7\u6027\u597d\uff0c\u7528\u4e8e\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u6709\u6548\uff1b\u65e0\u8fdb\u5c55\u751f\u5b58\u671f(PFS)\u548c\u603b\u751f\u5b58\u671f(OS)\u83b7\u76ca\uff0c\u5728PD-L1\u22651%\u548cPD-L1&lt;1%\u7684\u60a3\u8005\u4e2d\uff0c\u5747\u89c2\u5bdf\u5230\u76f8\u4f3c\u7684\u751f\u5b58\u66f2\u7ebf\u3002\u7279\u522b\u662fPD-L1\u22651%\u7684\u9cde\u764c\u60a3\u8005\u83b7\u76ca\u660e\u663e\u3002<\/p>\n<p>\u622a\u81f32021\u5e741\u670819\u65e5\uff0c\u5171\u5165\u7ec487\u4f8b\u672a\u63a5\u53d7\u8fc7\u7cfb\u7edf\u6cbb\u7597\u7684\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\uff0c\u5176\u4e2d51\u4f8b\u975e\u9cde\u764c\u60a3\u8005\uff0c36\u4f8b\u9cde\u764c\u60a3\u8005\u300246\u4f8b\u60a3\u8005PD-L1\u22651%\uff0c37\u4f8b\u60a3\u8005PD-L1&lt;1%\u3002\u4e2d\u4f4d\u6cbb\u7597\u65f6\u95f421\u5468\u3002<\/p>\n<p><b>\u5728<\/b><b>81\u4f8b\u7597\u6548\u53ef\u8bc4\u4f30\u7684\u60a3\u8005\u4e2d\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a50.6% 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