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type=\"disc\">\n<li>87\u4f8b\u60a3\u8005\uff0898.9%\uff09\u51fa\u73b0\u81f3\u5c111\u8d77\u4efb\u4f55\u7ea7\u522b\u7684\u6cbb\u7597\u4e2d\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TEAE\uff09\uff0c54\u4f8b\u60a3\u8005\uff0861.4%\uff09\u51fa\u73b0\u81f3\u5c111\u8d773\u7ea7\u53ca\u4ee5\u4e0a\u7684TEAE <\/li>\n<li>87\u4f8b\u60a3\u8005\uff0898.9%\uff09\u51fa\u73b0\u81f3\u5c111\u8d77\u4efb\u4f55\u7ea7\u522b\u7684\u6cbb\u7597\u76f8\u5173TEAE\uff0c53\u4f8b\u60a3\u8005\uff0860.2%\uff09\u51fa\u73b0\u81f3\u5c111\u8d773\u7ea7\u53ca\u4ee5\u4e0a\u7684\u6cbb\u7597\u76f8\u5173TEAE\uff0c\u6700\u5e38\u89c1\u7684TEAE\uff08\u22655%\uff09\u4e3a\u8d2b\u8840\uff0839.8%\uff09\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\uff0829.5%\uff09\u3001\u767d\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\uff0821.6%\uff09\u3001\u8840\u5c0f\u677f\u8ba1\u6570\u964d\u4f4e\uff089.1%\uff09\u3001\u767d\u7ec6\u80de\u51cf\u5c11\u75c7\uff085.7%\uff09\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff085.7%\uff09 <\/li>\n<li>19\u4f8b\u60a3\u8005\uff0821.6%\uff09\u51fa\u73b0\u4e25\u91cdTEAE\uff0c15\u4f8b\u60a3\u8005\uff0817.0%\uff09\u51fa\u73b0\u4e25\u91cd\u6cbb\u7597\u76f8\u5173TEAE <\/li>\n<li>2\u4f8b\u60a3\u8005\u56e0TEAE\u800c\u7ec8\u6b62\u6cbb\u7597\uff0c\u5747\u4e0e\u6cbb\u7597\u76f8\u5173 <\/li>\n<li>1\u4f8b\u60a3\u8005\uff081.1%\uff09\u56e0TEAE\u6b7b\u4ea1\uff0c\u672a\u51fa\u73b0\u5bfc\u81f4\u6b7b\u4ea1\u7684\u6cbb\u7597\u76f8\u5173TEAE<\/li>\n<\/ul>\n<p><b>\u767e\u6c47\u6cfd<\/b><b><sup>&reg;<\/sup><\/b><b>\u5bf9\u6bd4\u5b89\u6170\u5242\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80c3\u764c\u7684<\/b><b>2<\/b><b>\u671f\u8bd5\u9a8c\u7ed3\u679c<\/b><\/p>\n<p><i>\u6d77\u62a5\u7f16\u53f7<\/i><i>3109<\/i><\/p>\n<p>PARALLEL 303\u662f\u4e00\u9879\u53cc\u76f2\u3001\u968f\u673a\u3001\u591a\u4e2d\u5fc32\u671f\u8bd5\u9a8c\uff08NCT03427814\uff09\uff0c\u767e\u6c47\u6cfd<sup>&reg;<\/sup>\u5bf9\u6bd4\u5b89\u6170\u5242\u4f5c\u4e3a\u7ef4\u6301\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u5bf9\u94c2\u7c7b\u836f\u7269\u4e00\u7ebf\u5316\u7597\u6709\u7f13\u89e3\u7684\u4e0d\u53ef\u624b\u672f\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80c3\u764c\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u8bd5\u9a8c\u5171\u5165\u7ec4136\u4f8b\u60a3\u8005\uff0c\u7531\u4e8e\u5165\u7ec4\u8017\u65f6\u957f\uff0c\u4e14\u8be5\u60a3\u8005\u4eba\u7fa4\u7684\u6807\u51c6\u6cbb\u7597\u53d1\u751f\u53d8\u5316\uff0c\u672c\u8bd5\u9a8c\u672a\u8fbe\u5230\u8ba1\u5212\u7684\u7ea6540\u4f8b\u60a3\u8005\u5165\u7ec4\u76ee\u6807\u3002\u60a3\u8005\u4ee51\uff1a1\u7684\u6bd4\u4f8b\u968f\u673a\u5230\u4e24\u7ec4\uff0c\u63a5\u53d7\u767e\u6c47\u6cfd<sup>&reg;<\/sup>\uff08n=71\uff09\u6216\u5b89\u6170\u5242\uff08n=65\uff0960 mg\u53e3\u670d\uff0c\u6bcf\u65e5\u4e24\u6b21\uff0c\u6bcf28\u5929\u4e3a\u4e00\u4e2a\u5468\u671f\u3002\u4e3b\u8981\u7ec8\u70b9\u4e3a\u7814\u7a76\u8005\u6839\u636eRECIST 1.1\u7248\u8bc4\u4f30\u7684PFS\uff1b\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u81f3\u540e\u7eed\u6cbb\u7597\u7684\u65f6\u95f4\uff08TSST\uff09\u3001\u7814\u7a76\u8005\u8bc4\u4f30\u7684ORR\u3001DoR\u548c\u81f3\u7f13\u89e3\u65f6\u95f4\uff08TTR\uff09\u3001OS\u548c\u5b89\u5168\u6027\u3002\u5728\u8fdb\u884c\u6570\u636e\u5206\u6790\u65f6\uff0cOS\u6570\u636e\u5c1a\u4e0d\u6210\u719f\u3002<\/p>\n<p>\u610f\u5927\u5229\u90a3\u4e0d\u52d2\u65af\u7b2c\u4e8c\u5927\u5b66Fortunato Ciardiello\u533b\u5b66\u535a\u58eb\u517c\u8bd5\u9a8c\u4e3b\u8981\u7814\u7a76\u8005\u8868\u793a\uff1a\u201c\u8bb8\u591a\u80c3\u764c\u60a3\u8005\u5728\u75be\u75c5\u540e\u671f\u5bf9\u76ee\u524d\u53ef\u7528\u7684\u7597\u6cd5\u4ea7\u751f\u4e86\u8010\u836f\u6027\uff0c\u6301\u7eed\u8fdb\u884c\u7814\u7a76\u5bf9\u4e8e\u5bfb\u627e\u6709\u671b\u6539\u5584\u60a3\u8005\u9884\u540e\u548c\u751f\u5b58\u7684\u836f\u7269\u81f3\u5173\u91cd\u8981\u3002\u5c3d\u7ba1PARALLEL 303\u7814\u7a76\u672a\u663e\u793a\u51fa\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u5dee\u5f02\uff0c\u4f46\u8bd5\u9a8c\u7ed3\u679c\u6709\u52a9\u4e8e\u6211\u4eec\u6df1\u5165\u4e86\u89e3PARP\u6291\u5236\u5242\u5728\u8f6c\u79fb\u6027\u80c3\u764c\u4e2d\u7684\u4f5c\u7528\uff0c\u8fdb\u4e00\u6b65\u652f\u6301\u4e86\u767e\u6c47\u6cfd<sup>&reg;<\/sup>\u7684\u5b89\u5168\u6027\u7279\u5f81\u548c\u9488\u5bf9\u5408\u9002\u60a3\u8005\u4eba\u7fa4\u7684\u6f5c\u5728\u4e34\u5e8a\u83b7\u76ca\u3002\u201d<\/p>\n<p>\u622a\u81f3\u6570\u636e\u622a\u6b62\u65e5\u671f2020\u5e7412\u67087\u65e5\uff0c\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a8.0\u4e2a\u6708\uff08\u767e\u6c47\u6cfd<sup>&reg;<\/sup>\u7ec47.9\u4e2a\u6708\uff1b\u5b89\u6170\u5242\u7ec48.0\u4e2a\u6708\uff09\u3002<\/p>\n<p>\u767e\u6c47\u6cfd<sup>&reg;<\/sup>\u7ec4\u7684\u4e2d\u4f4dPFS\u4e3a3.7\u4e2a\u6708\uff0895% CI\uff1a1.9\uff0c5.3\uff09\uff0c\u9ad8\u4e8e\u5b89\u6170\u5242\u7ec4\u76842.1\u4e2a\u6708\uff0895% CI\uff1a1.9\uff0c3.8\uff09\uff0c\u4f46\u5dee\u5f02\u672a\u8fbe\u5230\u7edf\u8ba1\u5b66\u663e\u8457\u6027\uff08p=0.1428\uff1bHR=0.799[95% CI\uff1a0.5\uff0c1.2]\uff09\u3002\u5176\u4ed6\u6709\u6548\u6027\u7ed3\u679c\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u767e\u6c47\u6cfd<sup>&reg;<\/sup>\u7ec4\u7684\u4e2d\u4f4dOS\u4e3a10.2\u4e2a\u6708\uff0895% CI\uff1a8.7\uff0c16.3\uff09\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a12.0\u4e2a\u6708\uff0895% CI\uff1a8.2\uff0c\u65e0\u6cd5\u4f30\u8ba1[NE]\uff09 <\/li>\n<li>\u767e\u6c47\u6cfd<sup>&reg;<\/sup>\u7ec4\u7684ORR\u4e3a7.7%\uff0895% CI\uff1a1.6\uff0c20.9\uff09\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a6.3%\uff0895% CI\uff1a0.8\uff0c20.8\uff09 <\/li>\n<li>\u767e\u6c47\u6cfd<sup>&reg;<\/sup>\u7ec4\u7684\u4e2d\u4f4dDoR\u4e3a3.6\u4e2a\u6708\uff0895% CI\uff1a3.5\uff0cNE\uff09\uff0c\u5b89\u6170\u5242\u7ec4\u4e3aNE\uff0895% CI\uff1a5.6\uff0cNE\uff09 <\/li>\n<li>\u767e\u6c47\u6cfd<sup>&reg;<\/sup>\u7ec4\u7684\u4e2d\u4f4dTTR\u4e3a3.7\u4e2a\u6708\uff08\u8303\u56f4\uff1a1.8\uff0c7.3\uff09\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a1.9\u4e2a\u6708\uff08\u8303\u56f4\uff1a1.9\uff0c1.9\uff09<\/li>\n<\/ul>\n<p>\u5728\u672c\u8bd5\u9a8c\u4e2d\uff0c\u767e\u6c47\u6cfd<sup>&reg;<\/sup>\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d\uff0c\u672a\u89c2\u5bdf\u5230\u65b0\u7684\u5b89\u5168\u6027\u8b66\u793a\u3002\u5b89\u5168\u6027\u7ed3\u679c\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u767e\u6c47\u6cfd<sup>&reg;<\/sup>\u7ec4\u670965\u4f8b\u60a3\u8005\uff0891.5%\uff09\u51fa\u73b0\u81f3\u5c111\u8d77\u4efb\u4f55\u7ea7\u522b\u7684TEAE\uff0c\u5b89\u6170\u5242\u7ec4\u670961\u4f8b\u60a3\u8005\uff0893.8%\uff09 <\/li>\n<li>\u767e\u6c47\u6cfd<sup>&reg;<\/sup>\u7ec4\u5206\u522b\u670914\u4f8b\uff0819.7%\uff09\u548c29\u4f8b\uff0840.8%\uff09\u60a3\u8005\u51fa\u73b0\u4e25\u91cdTEAE\u548c3\u7ea7\u53ca\u4ee5\u4e0aTEAE\uff0c\u5b89\u6170\u5242\u7ec4\u5206\u522b\u670910\u4f8b\uff0815.4%\uff09\u548c20\u4f8b\u60a3\u8005\uff0830.8%\uff09 <\/li>\n<li>\u767e\u6c47\u6cfd<sup>&reg;<\/sup>\u7ec4\u4e2d\u6700\u5e38\u89c1\uff08\u226510%\uff09\u7684TEAE\u5305\u62ec\u8d2b\u8840\uff0836.6%\uff09\u3001\u6076\u5fc3\uff0832.4%\uff09\u3001\u98df\u6b32\u4e0b\u964d\uff0826.8%\uff09\u3001\u5455\u5410\uff0823.9%\uff09\u3001\u4e4f\u529b\uff0821.1%\uff09\u3001\u8179\u6cfb\uff0818.3%\uff09\u3001\u4e0a\u8179\u75db\uff0816.9%\uff09\u3001\u5929\u95e8\u51ac\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\u5347\u9ad8\uff08AST\uff1b12.7%\uff09\u3001\u4e19\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\u5347\u9ad8\uff08ALT\uff1b11.3%\uff09\u3001\u8179\u75db\uff0811.3%\uff09\u3001\u4fbf\u79d8\uff0811.3%\uff09\u548c\u767d\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\uff0811.3%\uff09 <\/li>\n<li>\u5b89\u6170\u5242\u7ec4\u4e2d\u6700\u5e38\u89c1\uff08\u2265 10%\uff09\u7684TEAE\u5305\u62ec\u8179\u75db\uff0818.5%\uff09\u3001\u6076\u5fc3\uff0816.9%\uff09\u3001\u5916\u5468\u611f\u89c9\u795e\u7ecf\u75c5\uff0813.8%\uff09\u3001\u4e4f\u529b\uff0816.9%\uff09\u3001\u8d2b\u8840\uff0812.3%\uff09\u3001\u98df\u6b32\u4e0b\u964d\uff0812.3%\uff09\u3001\u541e\u54bd\u56f0\u96be\uff0812.3%\uff09\u3001\u4e0a\u8179\u75db\uff0810.8%\uff09\u3001\u4fbf\u79d8\uff0810.8%\uff09\u548c\u8179\u6cfb\uff0810.8%\uff09 <\/li>\n<li>\u767e\u6c47\u6cfd<sup>&reg;<\/sup>\u7ec4\u67098\u4f8b\u60a3\u8005\uff0811.3%\uff09\u56e0TEAE\u800c\u7ec8\u6b62\u6cbb\u7597\uff0c\u5b89\u6170\u5242\u7ec4\u67092\u4f8b\uff083.1%\uff09 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