{"id":33108,"date":"2021-06-04T20:00:00","date_gmt":"2021-06-04T13:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021060420000033108"},"modified":"2021-06-05T21:40:49","modified_gmt":"2021-06-05T13:40:49","slug":"%e7%99%be%e6%b5%8e%e7%a5%9e%e5%b7%9e%e5%9c%a82021%e5%b9%b4%e7%be%8e%e5%9b%bd%e4%b8%b4%e5%ba%8a%e8%82%bf%e7%98%a4%e5%ad%a6%e4%bc%9a%ef%bc%88asco%ef%bc%89%e5%b9%b4%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021060420000033108","title":{"rendered":"\u767e\u6d4e\u795e\u5dde\u57282021\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a\u516c\u5e03\u4e24\u9879\u767e\u6cfd\u5b89\uff08R\uff09\u5173\u952e\u6027\u8bd5\u9a8c\u7684\u4e34\u5e8a\u6570\u636e"},"content":{"rendered":"<p><p><i>\u76f8\u6bd4\u5316\u7597\uff0c\u767e\u6cfd\u5b89<\/i><i><sup>&reg;<\/sup><\/i><i>\u7528\u4e8e\u65e2\u5f80\u7ecf\u6cbb\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u60a3\u8005\u663e\u793a\u51fa\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u603b\u751f\u5b58\u671f\u6539\u5584\uff0c\u53ca\u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5f81<\/i><\/p>\n<p><i>\u767e\u6cfd\u5b89<\/i><i><sup>&reg;<\/sup><\/i><i>\u6cbb\u7597<\/i><i>MSI-H<\/i><i>\u6216<\/i><i>dMMR<\/i><i>\u5b9e\u4f53\u7624\u60a3\u8005\u663e\u793a\u51fa\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u603b\u7f13\u89e3\u7387\uff0c\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d<\/i><i>&nbsp;<\/i><\/p>\n<p>\u7f8e\u56fd\u9ebb\u7701\u5251\u6865\u548c\u4e2d\u56fd\u5317\u4eac2021\u5e746\u67084\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; <u><a target=\"_blank\" href=\"https:\/\/www.beigene.com\/\" rel=\"nofollow noopener\">\u767e\u6d4e\u795e\u5dde<\/a><\/u>\uff08\u7eb3\u65af\u8fbe\u514b\u4ee3\u7801\uff1aBGNE\uff1b\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a06160\uff09\uff0c\u662f\u4e00\u5bb6\u5168\u7403\u5316\u7684\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5728\u4e16\u754c\u8303\u56f4\u5185\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u521b\u65b0\u836f\u7269\u3002\u516c\u53f8\u4eca\u65e5\u57282021\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u5e74\u4f1a\uff08ASCO 2021\uff09\u4e0a\u516c\u5e03\u4e86\u5176\u6297PD-1\u6297\u4f53\u836f\u7269\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\uff08\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u7684\u4e24\u9879\u5173\u952e\u6027\u8bd5\u9a8c\u7684\u4e34\u5e8a\u6570\u636e\uff0c\u5305\u62ec\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u5bf9\u6bd4\u5316\u7597\u7528\u4e8e\u65e2\u5f80\u7ecf\u6cbb\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\uff08ESCC\uff09\u76843\u671f\u8bd5\u9a8cRATIONALE 302\uff0c\u548c\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7528\u4e8e\u65e2\u5f80\u7ecf\u6cbb\u3001\u5c40\u90e8\u665a\u671f\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ad8\u5ea6\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u578b\uff08MSI-H\uff09\u6216\u9519\u914d\u4fee\u590d\u7f3a\u9677\u578b\uff08dMMR\uff09\u5b9e\u4f53\u7624\u7684\u5173\u952e\u60272\u671f\u8bd5\u9a8c\u30022021\u5e74\u7684ASCO\u4f1a\u8bae\u5c06\u4e8e2021\u5e746\u67084\u65e5\u81f38\u65e5\u5728\u7ebf\u4e0a\u4e3e\u884c\u3002<\/p>\n<p>\u767e\u6d4e\u795e\u5dde\u514d\u75ab\u80bf\u7624\u5b66\u9996\u5e2d\u533b\u5b66\u5b98\u8d32\u52c7\u535a\u58eb\u8868\u793a\uff1a\u201c\u6211\u4eec\u5f88\u9ad8\u5174\u80fd\u591f\u5728\u4eca\u5e74ASCO\u4e0a\u540c\u5927\u5bb6\u5206\u4eab\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7684\u4e24\u9879\u5173\u952e\u6027\u8bd5\u9a8c\u4e2d\u8fd9\u4e9b\u9f13\u821e\u4eba\u5fc3\u7684\u6570\u636e\u7ed3\u679c\uff0c\u4e24\u9879\u8bd5\u9a8c\u5206\u522b\u662f\u6cbb\u7597ESCC\u7684\u8bd5\u9a8c\u2014\u2014RATIONALE 302\uff0c\u548c\u6cbb\u7597MSI-H\u6216dMMR\u5b9e\u4f53\u7624\u7684\u5173\u952e\u60272\u671f\u8bd5\u9a8c\uff0c\u6211\u4eec\u4e5f\u8ba1\u5212\u5c31\u6b64\u6570\u636e\u4e0e\u76d1\u7ba1\u90e8\u95e8\u5c55\u5f00\u6c9f\u901a\u4ea4\u6d41\u3002\u6211\u4eec\u4e0e\u5408\u4f5c\u4f19\u4f34\u8bfa\u534e\u516c\u53f8\u81f4\u529b\u4e8e\u5728\u5e7f\u6cdb\u7684\u5168\u7403\u4e34\u5e8a\u9879\u76ee\u4e2d\u63a8\u8fdb\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u5355\u836f\u6cbb\u7597\u548c\u4e0e\u5176\u4ed6\u6297\u80bf\u7624\u7597\u6cd5\u7684\u8054\u5408\u7528\u836f\u3002\u968f\u7740\u638c\u63e1\u8d8a\u6765\u8d8a\u591a\u7684\u4e34\u5e8a\u8bc1\u636e\uff0c\u6211\u4eec\u5e0c\u671b\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u53ef\u4ee5\u6210\u4e3a\u4e00\u6b3e\u610f\u4e49\u6df1\u8fdc\u7684\u514d\u75ab\u6cbb\u7597\u836f\u7269\uff0c\u9020\u798f\u5168\u7403\u66f4\u591a\u7684\u60a3\u8005\u3002\u201d<\/p>\n<p><b>\u767e\u6cfd\u5b89<\/b><b><sup>&reg;<\/sup><\/b><b>\u5bf9\u6bd4\u5316\u7597\u7528\u4e8e\u65e2\u5f80\u7ecf\u6cbb\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027<\/b><b>ESCC<\/b><b>\u7684<\/b><b>RATIONALE 302<\/b><b>\u8bd5\u9a8c\u7684\u4e3b\u8981\u7ed3\u679c<\/b><\/p>\n<p><i>\u6d77\u62a5\u7f16\u53f7<\/i><i>4012<\/i><\/p>\n<p>RATIONALE 302\u662f\u4e00\u9879\u968f\u673a\u3001\u5f00\u653e\u6027\u3001\u591a\u4e2d\u5fc3\u7684\u5168\u74033\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT03430843\uff09\uff0c\u65e8\u5728\u8bc4\u4f30\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u5bf9\u6bd4\u7814\u7a76\u8005\u9009\u62e9\u7684\u5316\u7597\u4f5c\u4e3a\u665a\u671f\u6216\u8f6c\u79fb\u6027ESCC\u60a3\u8005\u4e8c\u7ebf\u6cbb\u7597\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u8bd5\u9a8c\u4e3b\u8981\u7ec8\u70b9\u662f\u610f\u5411\u6027\u6cbb\u7597\uff08ITT\uff09\u4eba\u7fa4\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\uff1b\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u662fPD-L1\u9ad8\u8868\u8fbe\u60a3\u8005\uff08\u5b9a\u4e49\u4e3a\u76ee\u6d4b\u4f30\u8ba1\u7efc\u5408\u9633\u6027\u8bc4\u5206 [vCPS] \u226510%\uff09\u7684OS\uff0c\u5176\u4ed6\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3001\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u3001\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DoR\uff09\u548c\u5b89\u5168\u6027\u3002\u5171\u6709512\u4f8b\u6765\u81ea\u4e9a\u6d32\u3001\u6b27\u6d32\u548c\u5317\u7f8e\u768411\u4e2a\u56fd\u5bb6\u6216\u5730\u533a\u7684\u60a3\u8005\u5165\u7ec4\u8bd5\u9a8c\uff0c\u8fd9\u4e9b\u60a3\u8005\u4ee51\uff1a1\u7684\u6bd4\u4f8b\u968f\u673a\u5206\u914d\u81f3\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7ec4\u6216\u5316\u7597\u7ec4\uff08\u5316\u7597\u7ec4\u7684\u6cbb\u7597\u65b9\u6848\u4e3a\u7814\u7a76\u8005\u9009\u62e9\u7684\u7d2b\u6749\u9187\u3001\u591a\u897f\u4ed6\u8d5b\u6216\u4f0a\u7acb\u66ff\u5eb7\uff09\u3002&nbsp;<\/p>\n<p>\u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662\u533b\u5b66\u535a\u58eb\u517c\u8be5\u9879\u8bd5\u9a8c\u7684\u4e3b\u8981\u7814\u7a76\u8005\u6c88\u7433\u6559\u6388\u8bc4\u8bba\u9053\uff1a\u201c\u665a\u671f\u6216\u8f6c\u79fb\u6027ESCC\u60a3\u8005\u7684\u9884\u540e\u901a\u5e38\u4e0d\u7406\u60f3\uff0c\u4e94\u5e74\u751f\u5b58\u7387\u4ec5\u7ea65%\u3002RATIONALE 302\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u663e\u8457\u5ef6\u957f\u4e86\u8fd9\u4e9b\u60a3\u8005\u7684\u751f\u5b58\u671f\uff0c\u5728\u9884\u5b9a\u4e49\u7684\u4e9a\u7ec4\uff08\u5305\u62ecPD-L1\u8868\u8fbe\u548c\u60a3\u8005\u4eba\u79cd\uff09\u4e2d\u89c2\u5bdf\u5230\u8d8b\u52bf\u4e00\u81f4\u7684\u751f\u5b58\u83b7\u76ca\u3002\u6b64\u5916\uff0c\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7684\u5b89\u5168\u6027\u8f83\u6709\u4f18\u52bf\uff0c\u672a\u51fa\u73b0\u65b0\u7684\u5b89\u5168\u6027\u8b66\u793a\u3002\u6211\u4eec\u671f\u5f85\u8fd9\u6b3e\u6297PD-1\u6297\u4f53\u836f\u7269\u6210\u4e3a\u63a5\u53d7\u8fc7\u65e2\u5f80\u5168\u8eab\u6cbb\u7597\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027ESCC\u60a3\u8005\u7684\u6cbb\u7597\u65b0\u9009\u62e9\u3002\u201d<\/p>\n<p>\u622a\u81f3\u6570\u636e\u622a\u6b62\u65e5\u671f2020\u5e7412\u67081\u65e5\uff0c\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7ec4\u4e0e\u5316\u7597\u7ec4\u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u5206\u522b\u4e3a8.5\u4e2a\u6708\u548c5.8\u4e2a\u6708\u3002<\/p>\n<p>\u4e0e\u5316\u7597\u76f8\u6bd4\uff0c\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u5728ITT\u4eba\u7fa4\uff08\u4e3b\u8981\u7ec8\u70b9\uff09\u548cPD-L1\u9ad8\u8868\u8fbe\u60a3\u8005\uff08\u5173\u952e\u6b21\u8981\u7ec8\u70b9\uff09\u4e2d\u5747\u663e\u793a\u51fa\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u548c\u4e34\u5e8a\u610f\u4e49\u7684OS\u6539\u5584\u3002\u6709\u6548\u6027\u7ed3\u679c\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u5728ITT\u4eba\u7fa4\u4e2d\uff0c\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7ec4\u7684\u4e2d\u4f4dOS\u4e3a8.6\u4e2a\u6708\uff0895%CI\uff1a7.5\uff0c10.4\uff09\uff0c\u5316\u7597\u7ec4\u4e3a6.3\u4e2a\u6708\uff0895% CI\uff1a5.3\uff0c7.0\uff09\uff08<i>p <\/i>= 0.0001\uff1b\u98ce\u9669\u6bd4[HR] = 0.70 [95% CI\uff1a0.57\uff0c0.85]\uff09\u3002\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7ec46\u4e2a\u6708\u548c12\u4e2a\u6708\u7684OS\u7387\u5206\u522b\u4e3a62.3%\u548c37.4%\uff0c\u5316\u7597\u7ec4\u5206\u522b\u4e3a51.8%\u548c23.7% <\/li>\n<li>\u5728PD-L1\u9ad8\u8868\u8fbe\u60a3\u8005\u4e2d\uff0c\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7ec4\u7684\u4e2d\u4f4dOS\u4e3a10.3\u4e2a\u6708\uff0895% CI\uff1a8.5\uff0c16.1\uff09\uff0c\u5316\u7597\u7ec4\u4e3a6.8\u4e2a\u6708\uff0895% CI\uff1a4.1\uff0c8.3\uff09\uff08<i>p <\/i>= 0.0006\uff1bHR = 0.54 [95% CI\uff1a0.36\uff0c0.79]\uff09\u3002\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7ec46\u4e2a\u6708\u548c12\u4e2a\u6708\u7684OS\u7387\u5206\u522b\u4e3a67.4%\u548c44.0%\uff0c\u5316\u7597\u7ec4\u5206\u522b\u4e3a50.8%\u548c27.0% <\/li>\n<li>\u8bd5\u9a8c\u4e2d\uff0c\u4e24\u4e2a\u6cbb\u7597\u7ec4\u7684PFS\u66f2\u7ebf\u5728\u8f83\u665a\u65f6\u95f4\u51fa\u73b0\u5206\u79bb\u3002\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7ec4\u7684\u4e2d\u4f4dPFS\u4e3a1.6\u4e2a\u6708\uff0895% CI\uff1a1.4\uff0c2.7\uff09\uff0c\u5316\u7597\u7ec4\u4e3a2.1\u4e2a\u6708\uff0895% CI\uff1a1.5\uff0c2.7\uff09\uff08HR = 0.83 [95% CI\uff1a0.67\uff0c1.01]\uff09\u3002\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7ec46\u4e2a\u6708\u548c12\u4e2a\u6708\u7684PFS\u7387\u5206\u522b\u4e3a21.7%\u548c12.7%\uff0c\u5316\u7597\u7ec4\u5206\u522b\u4e3a14.9%\u548c1.9% <\/li>\n<li>\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7ec4\u7684ORR\u8f83\u9ad8\uff0c\u4e3a20.3%\uff0895%CI\uff1a15.6\uff0c25.8\uff09\uff0c\u5316\u7597\u7ec4\u4e3a9.8%\uff0895% CI\uff1a6.4\uff0c14.1\uff09 <\/li>\n<li>\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7ec4\u7684\u6297\u80bf\u7624\u7f13\u89e3\u66f4\u6301\u4e45\uff0c\u4e2d\u4f4dDoR\u4e3a7.1\u4e2a\u6708\uff0895% CI\uff1a4.1\uff0c11.3\uff09\uff0c\u5316\u7597\u7ec4\u4e3a4.0\u4e2a\u6708\uff0895% CI\uff1a2.1\uff0c8.2\uff09 <\/li>\n<\/ul>\n<p>\u76f8\u6bd4\u5316\u7597\uff0c\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7684\u5b89\u5168\u6027\u7279\u5f81\u8f83\u6709\u4f18\u52bf\uff0c\u672a\u51fa\u73b0\u65b0\u7684\u5b89\u5168\u6027\u8b66\u793a\u3002\u5b89\u5168\u6027\u7ed3\u679c\u5305\u62ec\uff1a <\/p>\n<ul type=\"disc\">\n<li>\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7ec4\u548c\u5316\u7597\u7ec4\u5206\u522b\u6709244\u4f8b\u60a3\u8005\uff0895.7%\uff09\u548c236\u4f8b\u60a3\u8005\uff0898.3%\uff09\u51fa\u73b0\u81f3\u5c111\u8d77\u4efb\u4f55\u7ea7\u522b\u7684\u6cbb\u7597\u4e2d\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TEAE\uff09 <\/li>\n<li>\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7ec4\u4e2d\u6709187\u4f8b\u60a3\u8005\uff0873.3%\uff09\u51fa\u73b0\u81f3\u5c111\u8d77\u4efb\u4f55\u7ea7\u522b\u7684\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\uff0c\u6700\u5e38\u89c1\u7684\uff08\u53d1\u751f\u7387\u226510%\uff09\u662f\u5929\u95e8\u51ac\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08AST\uff09\u5347\u9ad8\uff0811.4%\uff09\u3001\u8d2b\u8840\uff0811.0%\uff09\u548c\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u75c7\uff0810.2%\uff09 <\/li>\n<li>\u5316\u7597\u7ec4\u4e2d\u6709225\u4f8b\u60a3\u8005\uff0893.8%\uff09\u51fa\u73b0\u81f3\u5c111\u8d77\u4efb\u4f55\u7ea7\u522b\u7684\u4e8b\u4ef6\uff0c\u6700\u5e38\u89c1\u7684\uff08\u53d1\u751f\u7387\u2265 10%\uff09\u662f\u767d\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\uff0840.8%\uff09\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\uff0839.2%\uff09\u3001\u8d2b\u8840\uff0834.6%\uff09\u3001\u98df\u6b32\u51cf\u9000\uff0831.3%\uff09\u3001\u8179\u6cfb\uff0827.5%\uff09\u3001\u6076\u5fc3\uff0827.5%\uff09\u3001\u5455\u5410\uff0817.9%\uff09\u3001\u8131\u53d1\uff0817.5%\uff09\u3001\u4e0d\u9002\uff0814.6%\uff09\u3001\u75b2\u4e4f\uff0813.8%\uff09\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff0812.9%\uff09\u3001\u767d\u7ec6\u80de\u51cf\u5c11\u75c7\uff0812.5%\uff09\u3001\u4e4f\u529b\uff0811.7%\uff09\u3001\u4fbf\u79d8\uff0810.4%\uff09\u548c\u4f53\u91cd\u51cf\u8f7b\uff0810.4%\uff09 <\/li>\n<li>\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7ec4\u5206\u522b\u6709118\u4f8b\u60a3\u8005\uff0846.3%\uff09\u548c48\u4f8b\u60a3\u8005\uff0818.8%\uff09\u51fa\u73b0\u4e863\u7ea7\u53ca\u4ee5\u4e0aTEAE\u548cTRAE\uff0c\u5316\u7597\u7ec4\u5206\u522b\u6709163\u4f8b\u60a3\u8005\uff0867.9%\uff09\u548c134\u4f8b\u60a3\u8005\uff0855.8%\uff09\u51fa\u73b03\u7ea7\u53ca\u4ee5\u4e0aTEAE\u548cTRAE <\/li>\n<li>\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7ec4\u5206\u522b\u6709105\u4f8b\u60a3\u8005\uff0841.2%\uff09\u548c36\u4f8b\u60a3\u8005\uff0814.1%\uff09\u51fa\u73b0\u4e86\u4e25\u91cdTEAE\u548cTRAE\uff0c\u5316\u7597\u7ec4\u5206\u522b\u6709105\u4f8b\u60a3\u8005\uff0843.8%\uff09\u548c47\u4f8b\u60a3\u8005\uff0819.6%\uff09\u60a3\u8005\u51fa\u73b0\u4e86\u4e25\u91cdTEAE\u548cTRAE <\/li>\n<li>\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7ec4\u5206\u522b\u670949\u4f8b\u60a3\u8005\uff0819.2%\uff09\u548c17\u4f8b\u60a3\u8005\uff086.7%\uff09\u51fa\u73b0\u4e86\u5bfc\u81f4\u6cbb\u7597\u7ec8\u6b62\u7684TEAE\u6216TRAE\uff0c\u5316\u7597\u7ec4\u5206\u522b\u670964\u4f8b\u60a3\u8005\uff0826.7%\uff09\u548c33\u4f8b\u60a3\u8005\uff0813.8%\uff09\u60a3\u8005\u51fa\u73b0\u4e86\u5bfc\u81f4\u6cbb\u7597\u7ec8\u6b62\u7684TEAE\u6216TRAE <\/li>\n<li>\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7ec4\u5206\u522b\u670914\u4f8b\u60a3\u8005\uff085.5%\uff09\u548c5\u4f8b\u60a3\u8005\uff082.0%\uff09\u56e0TEAE\u6216TRAE\u6b7b\u4ea1\uff0c\u5316\u7597\u7ec4\u670914\u4f8b\u60a3\u8005\uff085.8%\uff09\u548c7\u4f8b\u60a3\u8005\uff082.9%\uff09\u56e0TEAE\u6216TRAE\u6b7b\u4ea1<\/li>\n<\/ul>\n<p><b>\u9488\u5bf9<\/b><b>MSI-H<\/b><b>\u6216<\/b><b>dMMR<\/b><b>\u5b9e\u4f53\u7624\u7684\u5173\u952e\u6027<\/b><b>2<\/b><b>\u671f\u8bd5\u9a8c\u7684\u7ed3\u679c<\/b><\/p>\n<p><i>\u6d77\u62a5\u7f16\u53f7<\/i><i>2569<\/i><\/p>\n<p>\u672c\u9879\u5355\u81c2\u3001\u5f00\u653e\u6027\u3001\u591a\u4e2d\u5fc3\u7684\u5173\u952e\u60272\u671f\u8bd5\u9a8c\uff08NCT03736889\uff09\u65e8\u5728\u8bc4\u4ef7\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u5355\u836f\u6cbb\u7597\u65e2\u5f80\u7ecf\u6cbb\u3001\u5c40\u90e8\u665a\u671f\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027MSI-H\u6216dMMR\u5b9e\u4f53\u7624\u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\uff0c80\u4f8b\u4e2d\u56fd\u60a3\u8005\u5165\u7ec4\u7814\u7a76\u3002\u672c\u8bd5\u9a8c\u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u57fa\u4e8e\u72ec\u7acb\u5ba1\u67e5\u59d4\u5458\u4f1a\uff08IRC\uff09\u6839\u636eRECIST 1.1\u7248\u8bc4\u4f30\u7ed3\u679c\u786e\u5b9a\u7684ORR\uff0c\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u57fa\u4e8e\u7814\u7a76\u8005\u548cIRC\u8bc4\u4f30\u7ed3\u679c\u786e\u5b9a\u7684\u81f3\u7f13\u89e3\u65f6\u95f4\uff08TTR\uff09\u3001DoR\u3001\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u548cPFS\uff0c\u4ee5\u53caOS\u3001\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002<\/p>\n<p>\u5317\u4eac\u80bf\u7624\u533b\u9662\u533b\u5b66\u535a\u58eb\u517c\u8be5\u9879\u8bd5\u9a8c\u7684\u7814\u7a76\u8005\u674e\u5065\u6559\u6388\u8bc4\u8bba\u9053\uff1a\u201cMSI-H\u548cdMMR\u5b58\u5728\u4e8e\u591a\u79cd\u5b9e\u4f53\u7624\u4e2d\uff0c\u80c3\u80a0\u9053\u80bf\u7624\u5c24\u4e3a\u591a\u89c1\u3002\u73b0\u6709\u7684\u6587\u732e\u652f\u6301\u68c0\u67e5\u70b9\u6291\u5236\u5242\u4f5c\u4e3a\u6cdb\u7624\u79cd\u7684\u4e00\u79cd\u6cbb\u7597\u65b9\u6cd5\u3002\u5728\u8fd9\u9879\u5173\u952e\u60272\u671f\u8bd5\u9a8c\u4e2d\uff0c\u6211\u4eec\u89c2\u5bdf\u5230\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u5728\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\u4e2d\u7684\u4e00\u81f4\u7f13\u89e3\uff0c\u4e14\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d\u3002\u6211\u4eec\u5c06\u7ee7\u7eed\u5bf9\u60a3\u8005\u8fdb\u884c\u957f\u671f\u968f\u8bbf\u8bc4\u4f30\uff0c\u5e76\u671f\u5f85\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u80fd\u6210\u4e3aMSI-H\/dMMR\u5b9e\u4f53\u7624\u60a3\u8005\u7684\u4e00\u9879\u6cbb\u7597\u65b0\u9009\u62e9\u3002\u201d<\/p>\n<p>\u622a\u81f3\u6570\u636e\u622a\u6b62\u65e5\u671f2020\u5e7412\u67087\u65e5\uff0c\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a11.78\u4e2a\u6708\u3002\u4e3b\u8981\u6709\u6548\u6027\u5206\u6790\u96c6\u7eb3\u516574\u4f8b\u60a3\u8005\uff0c\u5305\u62ec46\u4f8b\uff0862.2%\uff09\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u60a3\u8005\u548c28\u4f8b\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u3001\u80c3\u6216\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\uff08G\/GEJ\uff09\u764c\u60a3\u8005\u548c\u5176\u4ed6\u80bf\u7624\u7c7b\u578b\u60a3\u8005\u3002<\/p>\n<p>\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u663e\u793a\u51fa\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u548c\u6301\u4e45\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u5404\u80bf\u7624\u7c7b\u578b\u7684\u6709\u6548\u6027\u7ed3\u679c\u5448\u73b0\u51fa\u4e00\u81f4\u7684\u8d8b\u52bf\uff0c\u8bc1\u660e\u4e86\u6cdb\u7624\u79cd\u6cbb\u7597\u7684\u83b7\u76ca\u3002\u6709\u6548\u6027\u7ed3\u679c\u5305\u62ec\uff1a&nbsp;<\/p>\n<ul type=\"disc\">\n<li>\u4e3b\u8981\u6709\u6548\u6027\u5206\u6790\u96c6\u4e2d\uff0c\u57fa\u4e8eIRC\u8bc4\u4f30\u7ed3\u679c\u786e\u5b9a\u7684ORR\u4e3a45.9%\uff0895% CI\uff1a34.3\uff0c57.9\uff1b<i>p<\/i> &lt; 0.0001\uff09\uff0cCRC\u60a3\u8005\u7684ORR\u4e3a39.1%\uff0895% CI\uff1a25.1\uff0c54.6\uff09\uff0c\u5176\u4ed6\u80bf\u7624\u7c7b\u578b\u60a3\u8005\u7684ORR\u4e3a57.1%\uff0895% CI\uff1a37.2\uff0c75.5\uff09 <\/li>\n<li>4\u4f8b\u60a3\u8005\uff085.4%\uff09\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\uff0c\u5305\u62ec2\u4f8b\uff084.3%\uff09CRC\u60a3\u8005\uff0c\u5176\u4e2d1\u4f8b\u4e3aG\/GEJC\u60a3\u8005\uff0c\u53e61\u4f8b\u4e3a\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005 <\/li>\n<li>\u5728\u8fbe\u5230\u7f13\u89e3\u768434\u4f8b\u60a3\u8005\uff0845.9%\uff09\u4e2d\uff0c\u4e2d\u4f4dTTR\u4e3a10.5\u5468\uff0c\u672a\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\uff1b\u96641\u4f8b\u5f00\u59cb\u65b0\u6cbb\u7597\u7684\u60a3\u8005\u5916\uff0c\u5176\u4ed633\u4f8b\u60a3\u8005\u4ecd\u6301\u7eed\u7f13\u89e3\uff0c12\u4e2a\u6708\u7684DoR\u65e0\u4e8b\u4ef6\u7387\u4e3a100%\uff0c\u4e2d\u4f4dDoR\u672a\u8fbe\u5230 <\/li>\n<li>\u4e2d\u4f4dPFS\u548cOS\u672a\u8fbe\u5230\uff0c12\u4e2a\u6708\u65f6\u7684PFS\u7387\u548cOS\u7387\u5206\u522b\u4e3a59.3%\uff0895% CI\uff1a46.2\uff0c70.2\uff09\u548c75.3%\uff0895% CI\uff1a62.6\uff0c84.2\uff09\uff0c\u4e14CRC\u60a3\u8005\u4e0e\u5176\u4ed6\u80bf\u7624\u7c7b\u578b\u60a3\u8005\u4e4b\u95f4\u7684\u7ed3\u679c\u5448\u73b0\u51fa\u4e00\u81f4\u7684\u8d8b\u52bf <\/li>\n<\/ul>\n<p>\u5728\u7eb3\u5165\u6240\u670980\u4f8b\u60a3\u8005\u7684\u5b89\u5168\u6027\u5206\u6790\u96c6\u4e2d\uff0c\u767e\u6cfd\u5b89<sup>&reg;<\/sup>\u7684\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d\uff0c\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u53f7\u3002\u5b89\u5168\u6027\u7ed3\u679c\u4e0e\u75be\u75c5\u7684\u9884\u671f\u8868\u73b0\u548c\u5176\u4ed6\u6297PD-1\u6297\u4f53\u7684\u5df2\u77e5\u4f5c\u7528\u4e00\u81f4\uff0c\u5305\u62ec\uff1a <\/p>\n<ul type=\"disc\">\n<li>80\u4f8b\u60a3\u8005\uff08100%\uff09\u5747\u51fa\u73b0\u81f3\u5c111\u8d77\u4efb\u4f55\u7ea7\u522b\u7684TEAE\uff1b\u670979\u4f8b\u60a3\u8005\uff0898.8%\uff09\u51fa\u73b0\u81f3\u5c111\u8d77\u4efb\u4f55\u7ea7\u522b\u7684TRAE\uff0c\u6700\u5e38\u89c1\u7684\u662f\uff08\u53d1\u751f\u7387 \u226515%\uff09\u4e3a\u8d2b\u8840\uff0843.8%\uff09\u3001\u4e19\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08ALT\uff09\u5347\u9ad8\uff0828.8%\uff09\u3001\u8840\u80c6\u7ea2\u7d20\u5347\u9ad8\uff0825.0%\uff09\u3001AST\u5347\u9ad8\uff0823.8%\uff09\u3001\u767d\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\uff0822.5%\uff09\u3001\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u75c7\uff0818.8%\uff09\u3001\u76ae\u75b9\uff0818.8%\uff09\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\uff0815.0%\uff09 <\/li>\n<li>\u5206\u522b\u670938\u4f8b\u60a3\u8005\uff0847.5%\uff09\u548c34\u4f8b\u60a3\u8005\uff0842.5%\uff09\u51fa\u73b0\u4e863\u7ea7\u53ca\u4ee5\u4e0a\u7684TEAE\u548cTRAE <\/li>\n<li>\u5206\u522b\u670927\u4f8b\u60a3\u8005\uff0833.8%\uff09\u548c21\u4f8b\u60a3\u8005\uff0826.3%\uff09\u51fa\u73b0\u4e86\u4e25\u91cdTEAE\u548cTRAE <\/li>\n<li>4\u4f8b\u60a3\u8005\uff085.0%\uff09\u56e0TEAE\u548cTRAE\u800c\u7ec8\u6b62\u6cbb\u7597 <\/li>\n<li>\u5206\u522b\u67095\u4f8b\u60a3\u8005\uff086.3%\uff09\u548c3\u4f8b\u60a3\u8005\uff083.8%\uff09\u56e0TEAE\u548cTRAE\u6b7b\u4ea1<\/li>\n<\/ul>\n<p>\u6b32\u4e86\u89e3\u66f4\u591a\u5173\u4e8e\u767e\u6d4e\u795e\u5dde\u7814\u53d1\u548c\u5728ASCO\u4e0a\u76f8\u5173\u6d3b\u52a8\u7684\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<a target=\"_blank\" href=\"https:\/\/beigenevirtualexperience.com\/\" rel=\"nofollow noopener\">https:\/\/beigenevirtualexperience.com\/<\/a>\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u76f8\u6bd4\u5316\u7597\uff0c\u767e\u6cfd\u5b89&reg;\u7528\u4e8e\u65e2\u5f80\u7ecf\u6cbb\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u60a3\u8005\u663e\u793a\u51fa\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u603b\u751f\u5b58\u671f\u6539\u5584\uff0c\u53ca\u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5f81 \u767e\u6cfd\u5b89&reg;\u6cbb\u7597MSI-H\u6216dMMR\u5b9e\u4f53\u7624\u60a3\u8005\u663e\u793a\u51fa\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u603b\u7f13\u89e3\u7387\uff0c\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d&nbsp; \u7f8e\u56fd\u9ebb\u7701\u5251\u6865\u548c\u4e2d\u56fd\u5317\u4eac2021\u5e746\u67084\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u767e\u6d4e\u795e\u5dde\uff08\u7eb3\u65af\u8fbe\u514b\u4ee3\u7801\uff1aBGNE\uff1b\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a06160\uff09\uff0c\u662f\u4e00\u5bb6\u5168\u7403\u5316\u7684\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5728\u4e16\u754c\u8303\u56f4\u5185\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u521b\u65b0\u836f\u7269\u3002\u516c\u53f8\u4eca\u65e5\u57282021\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u5e74\u4f1a\uff08ASCO 2021\uff09\u4e0a\u516c\u5e03\u4e86\u5176\u6297PD-1\u6297\u4f53\u836f\u7269\u767e\u6cfd\u5b89&reg;\uff08\u66ff\u96f7\u5229\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff09\u7684\u4e24\u9879\u5173\u952e\u6027\u8bd5\u9a8c\u7684\u4e34\u5e8a\u6570\u636e\uff0c\u5305\u62ec\u767e\u6cfd\u5b89&reg;\u5bf9\u6bd4\u5316\u7597\u7528\u4e8e\u65e2\u5f80\u7ecf\u6cbb\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u72b6\u7ec6\u80de\u764c\uff08ESCC\uff09\u76843\u671f\u8bd5\u9a8cRATIONALE 302\uff0c\u548c\u767e\u6cfd\u5b89&reg;\u7528\u4e8e\u65e2\u5f80\u7ecf\u6cbb\u3001\u5c40\u90e8\u665a\u671f\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ad8\u5ea6\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u578b\uff08MSI-H\uff09\u6216\u9519\u914d\u4fee\u590d\u7f3a\u9677\u578b\uff08dMMR\uff09\u5b9e\u4f53\u7624\u7684\u5173\u952e\u60272\u671f\u8bd5\u9a8c\u30022021\u5e74\u7684ASCO\u4f1a\u8bae\u5c06\u4e8e2021\u5e746\u67084\u65e5\u81f38\u65e5\u5728\u7ebf\u4e0a\u4e3e\u884c\u3002 \u767e\u6d4e\u795e\u5dde\u514d\u75ab\u80bf\u7624\u5b66\u9996\u5e2d\u533b\u5b66\u5b98\u8d32\u52c7\u535a\u58eb\u8868\u793a\uff1a\u201c\u6211\u4eec\u5f88\u9ad8\u5174\u80fd\u591f\u5728\u4eca\u5e74ASCO\u4e0a\u540c\u5927\u5bb6\u5206\u4eab\u767e\u6cfd\u5b89&reg;\u7684\u4e24\u9879\u5173\u952e\u6027\u8bd5\u9a8c\u4e2d\u8fd9\u4e9b\u9f13\u821e\u4eba\u5fc3\u7684\u6570\u636e\u7ed3\u679c\uff0c\u4e24\u9879\u8bd5\u9a8c\u5206\u522b\u662f\u6cbb\u7597ESCC\u7684\u8bd5\u9a8c\u2014\u2014RATIONALE 302\uff0c\u548c\u6cbb\u7597MSI-H\u6216dMMR\u5b9e\u4f53\u7624\u7684\u5173\u952e\u60272\u671f\u8bd5\u9a8c\uff0c\u6211\u4eec\u4e5f\u8ba1\u5212\u5c31\u6b64\u6570\u636e\u4e0e\u76d1\u7ba1\u90e8\u95e8\u5c55\u5f00\u6c9f\u901a\u4ea4\u6d41\u3002\u6211\u4eec\u4e0e\u5408\u4f5c\u4f19\u4f34\u8bfa\u534e\u516c\u53f8\u81f4\u529b\u4e8e\u5728\u5e7f\u6cdb\u7684\u5168\u7403\u4e34\u5e8a\u9879\u76ee\u4e2d\u63a8\u8fdb\u767e\u6cfd\u5b89&reg;\u5355\u836f\u6cbb\u7597\u548c\u4e0e\u5176\u4ed6\u6297\u80bf\u7624\u7597\u6cd5\u7684\u8054\u5408\u7528\u836f\u3002\u968f\u7740\u638c\u63e1\u8d8a\u6765\u8d8a\u591a\u7684\u4e34\u5e8a\u8bc1\u636e\uff0c\u6211\u4eec\u5e0c\u671b\u767e\u6cfd\u5b89&reg;\u53ef\u4ee5\u6210\u4e3a\u4e00\u6b3e\u610f\u4e49\u6df1\u8fdc\u7684\u514d\u75ab\u6cbb\u7597\u836f\u7269\uff0c\u9020\u798f\u5168\u7403\u66f4\u591a\u7684\u60a3\u8005\u3002\u201d \u767e\u6cfd\u5b89&reg;\u5bf9\u6bd4\u5316\u7597\u7528\u4e8e\u65e2\u5f80\u7ecf\u6cbb\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027ESCC\u7684RATIONALE 302\u8bd5\u9a8c\u7684\u4e3b\u8981\u7ed3\u679c \u6d77\u62a5\u7f16\u53f74012 RATIONALE 302\u662f\u4e00\u9879\u968f\u673a\u3001\u5f00\u653e\u6027\u3001\u591a\u4e2d\u5fc3\u7684\u5168\u74033\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT03430843\uff09\uff0c\u65e8\u5728\u8bc4\u4f30\u767e\u6cfd\u5b89&reg;\u5bf9\u6bd4\u7814\u7a76\u8005\u9009\u62e9\u7684\u5316\u7597\u4f5c\u4e3a\u665a\u671f\u6216\u8f6c\u79fb\u6027ESCC\u60a3\u8005\u4e8c\u7ebf\u6cbb\u7597\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u8bd5\u9a8c\u4e3b\u8981\u7ec8\u70b9\u662f\u610f\u5411\u6027\u6cbb\u7597\uff08ITT\uff09\u4eba\u7fa4\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\uff1b\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u662fPD-L1\u9ad8\u8868\u8fbe\u60a3\u8005\uff08\u5b9a\u4e49\u4e3a\u76ee\u6d4b\u4f30\u8ba1\u7efc\u5408\u9633\u6027\u8bc4\u5206 [vCPS] \u226510%\uff09\u7684OS\uff0c\u5176\u4ed6\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3001\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u3001\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DoR\uff09\u548c\u5b89\u5168\u6027\u3002\u5171\u6709512\u4f8b\u6765\u81ea\u4e9a\u6d32\u3001\u6b27\u6d32\u548c\u5317\u7f8e\u768411\u4e2a\u56fd\u5bb6\u6216\u5730\u533a\u7684\u60a3\u8005\u5165\u7ec4\u8bd5\u9a8c\uff0c\u8fd9\u4e9b\u60a3\u8005\u4ee51\uff1a1\u7684\u6bd4\u4f8b\u968f\u673a\u5206\u914d\u81f3\u767e\u6cfd\u5b89&reg;\u7ec4\u6216\u5316\u7597\u7ec4\uff08\u5316\u7597\u7ec4\u7684\u6cbb\u7597\u65b9\u6848\u4e3a\u7814\u7a76\u8005\u9009\u62e9\u7684\u7d2b\u6749\u9187\u3001\u591a\u897f\u4ed6\u8d5b\u6216\u4f0a\u7acb\u66ff\u5eb7\uff09\u3002&nbsp; \u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662\u533b\u5b66\u535a\u58eb\u517c\u8be5\u9879\u8bd5\u9a8c\u7684\u4e3b\u8981\u7814\u7a76\u8005\u6c88\u7433\u6559\u6388\u8bc4\u8bba\u9053\uff1a\u201c\u665a\u671f\u6216\u8f6c\u79fb\u6027ESCC\u60a3\u8005\u7684\u9884\u540e\u901a\u5e38\u4e0d\u7406\u60f3\uff0c\u4e94\u5e74\u751f\u5b58\u7387\u4ec5\u7ea65%\u3002RATIONALE 302\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u767e\u6cfd\u5b89&reg;\u663e\u8457\u5ef6\u957f\u4e86\u8fd9\u4e9b\u60a3\u8005\u7684\u751f\u5b58\u671f\uff0c\u5728\u9884\u5b9a\u4e49\u7684\u4e9a\u7ec4\uff08\u5305\u62ecPD-L1\u8868\u8fbe\u548c\u60a3\u8005\u4eba\u79cd\uff09\u4e2d\u89c2\u5bdf\u5230\u8d8b\u52bf\u4e00\u81f4\u7684\u751f\u5b58\u83b7\u76ca\u3002\u6b64\u5916\uff0c\u767e\u6cfd\u5b89&reg;\u7684\u5b89\u5168\u6027\u8f83\u6709\u4f18\u52bf\uff0c\u672a\u51fa\u73b0\u65b0\u7684\u5b89\u5168\u6027\u8b66\u793a\u3002\u6211\u4eec\u671f\u5f85\u8fd9\u6b3e\u6297PD-1\u6297\u4f53\u836f\u7269\u6210\u4e3a\u63a5\u53d7\u8fc7\u65e2\u5f80\u5168\u8eab\u6cbb\u7597\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027ESCC\u60a3\u8005\u7684\u6cbb\u7597\u65b0\u9009\u62e9\u3002\u201d \u622a\u81f3\u6570\u636e\u622a\u6b62\u65e5\u671f2020\u5e7412\u67081\u65e5\uff0c\u767e\u6cfd\u5b89&reg;\u7ec4\u4e0e\u5316\u7597\u7ec4\u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u5206\u522b\u4e3a8.5\u4e2a\u6708\u548c5.8\u4e2a\u6708\u3002 \u4e0e\u5316\u7597\u76f8\u6bd4\uff0c\u767e\u6cfd\u5b89&reg;\u5728ITT\u4eba\u7fa4\uff08\u4e3b\u8981\u7ec8\u70b9\uff09\u548cPD-L1\u9ad8\u8868\u8fbe\u60a3\u8005\uff08\u5173\u952e\u6b21\u8981\u7ec8\u70b9\uff09\u4e2d\u5747\u663e\u793a\u51fa\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u548c\u4e34\u5e8a\u610f\u4e49\u7684OS\u6539\u5584\u3002\u6709\u6548\u6027\u7ed3\u679c\u5305\u62ec\uff1a \u5728ITT\u4eba\u7fa4\u4e2d\uff0c\u767e\u6cfd\u5b89&reg;\u7ec4\u7684\u4e2d\u4f4dOS\u4e3a8.6\u4e2a\u6708\uff0895%CI\uff1a7.5\uff0c10.4\uff09\uff0c\u5316\u7597\u7ec4\u4e3a6.3\u4e2a\u6708\uff0895% CI\uff1a5.3\uff0c7.0\uff09\uff08p = 0.0001\uff1b\u98ce\u9669\u6bd4[HR] = 0.70 [95% CI\uff1a0.57\uff0c0.85]\uff09\u3002\u767e\u6cfd\u5b89&reg;\u7ec46\u4e2a\u6708\u548c12\u4e2a\u6708\u7684OS\u7387\u5206\u522b\u4e3a62.3%\u548c37.4%\uff0c\u5316\u7597\u7ec4\u5206\u522b\u4e3a51.8%\u548c23.7% \u5728PD-L1\u9ad8\u8868\u8fbe\u60a3\u8005\u4e2d\uff0c\u767e\u6cfd\u5b89&reg;\u7ec4\u7684\u4e2d\u4f4dOS\u4e3a10.3\u4e2a\u6708\uff0895% CI\uff1a8.5\uff0c16.1\uff09\uff0c\u5316\u7597\u7ec4\u4e3a6.8\u4e2a\u6708\uff0895% CI\uff1a4.1\uff0c8.3\uff09\uff08p = 0.0006\uff1bHR = 0.54 [95% CI\uff1a0.36\uff0c0.79]\uff09\u3002\u767e\u6cfd\u5b89&reg;\u7ec46\u4e2a\u6708\u548c12\u4e2a\u6708\u7684OS\u7387\u5206\u522b\u4e3a67.4%\u548c44.0%\uff0c\u5316\u7597\u7ec4\u5206\u522b\u4e3a50.8%\u548c27.0% \u8bd5\u9a8c\u4e2d\uff0c\u4e24\u4e2a\u6cbb\u7597\u7ec4\u7684PFS\u66f2\u7ebf\u5728\u8f83\u665a\u65f6\u95f4\u51fa\u73b0\u5206\u79bb\u3002\u767e\u6cfd\u5b89&reg;\u7ec4\u7684\u4e2d\u4f4dPFS\u4e3a1.6\u4e2a\u6708\uff0895% CI\uff1a1.4\uff0c2.7\uff09\uff0c\u5316\u7597\u7ec4\u4e3a2.1\u4e2a\u6708\uff0895% CI\uff1a1.5\uff0c2.7\uff09\uff08HR = 0.83 [95% CI\uff1a0.67\uff0c1.01]\uff09\u3002\u767e\u6cfd\u5b89&reg;\u7ec46\u4e2a\u6708\u548c12\u4e2a\u6708\u7684PFS\u7387\u5206\u522b\u4e3a21.7%\u548c12.7%\uff0c\u5316\u7597\u7ec4\u5206\u522b\u4e3a14.9%\u548c1.9% \u767e\u6cfd\u5b89&reg;\u7ec4\u7684ORR\u8f83\u9ad8\uff0c\u4e3a20.3%\uff0895%CI\uff1a15.6\uff0c25.8\uff09\uff0c\u5316\u7597\u7ec4\u4e3a9.8%\uff0895% CI\uff1a6.4\uff0c14.1\uff09 \u767e\u6cfd\u5b89&reg;\u7ec4\u7684\u6297\u80bf\u7624\u7f13\u89e3\u66f4\u6301\u4e45\uff0c\u4e2d\u4f4dDoR\u4e3a7.1\u4e2a\u6708\uff0895% CI\uff1a4.1\uff0c11.3\uff09\uff0c\u5316\u7597\u7ec4\u4e3a4.0\u4e2a\u6708\uff0895% CI\uff1a2.1\uff0c8.2\uff09 \u76f8\u6bd4\u5316\u7597\uff0c\u767e\u6cfd\u5b89&reg;\u7684\u5b89\u5168\u6027\u7279\u5f81\u8f83\u6709\u4f18\u52bf\uff0c\u672a\u51fa\u73b0\u65b0\u7684\u5b89\u5168\u6027\u8b66\u793a\u3002\u5b89\u5168\u6027\u7ed3\u679c\u5305\u62ec\uff1a \u767e\u6cfd\u5b89&reg;\u7ec4\u548c\u5316\u7597\u7ec4\u5206\u522b\u6709244\u4f8b\u60a3\u8005\uff0895.7%\uff09\u548c236\u4f8b\u60a3\u8005\uff0898.3%\uff09\u51fa\u73b0\u81f3\u5c111\u8d77\u4efb\u4f55\u7ea7\u522b\u7684\u6cbb\u7597\u4e2d\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TEAE\uff09 \u767e\u6cfd\u5b89&reg;\u7ec4\u4e2d\u6709187\u4f8b\u60a3\u8005\uff0873.3%\uff09\u51fa\u73b0\u81f3\u5c111\u8d77\u4efb\u4f55\u7ea7\u522b\u7684\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\uff0c\u6700\u5e38\u89c1\u7684\uff08\u53d1\u751f\u7387\u226510%\uff09\u662f\u5929\u95e8\u51ac\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08AST\uff09\u5347\u9ad8\uff0811.4%\uff09\u3001\u8d2b\u8840\uff0811.0%\uff09\u548c\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u75c7\uff0810.2%\uff09 \u5316\u7597\u7ec4\u4e2d\u6709225\u4f8b\u60a3\u8005\uff0893.8%\uff09\u51fa\u73b0\u81f3\u5c111\u8d77\u4efb\u4f55\u7ea7\u522b\u7684\u4e8b\u4ef6\uff0c\u6700\u5e38\u89c1\u7684\uff08\u53d1\u751f\u7387\u2265 10%\uff09\u662f\u767d\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\uff0840.8%\uff09\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u964d\u4f4e\uff0839.2%\uff09\u3001\u8d2b\u8840\uff0834.6%\uff09\u3001\u98df\u6b32\u51cf\u9000\uff0831.3%\uff09\u3001\u8179\u6cfb\uff0827.5%\uff09\u3001\u6076\u5fc3\uff0827.5%\uff09\u3001\u5455\u5410\uff0817.9%\uff09\u3001\u8131\u53d1\uff0817.5%\uff09\u3001\u4e0d\u9002\uff0814.6%\uff09\u3001\u75b2\u4e4f\uff0813.8%\uff09\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff0812.9%\uff09\u3001\u767d\u7ec6\u80de\u51cf\u5c11\u75c7\uff0812.5%\uff09\u3001\u4e4f\u529b\uff0811.7%\uff09\u3001\u4fbf\u79d8\uff0810.4%\uff09\u548c\u4f53\u91cd\u51cf\u8f7b\uff0810.4%\uff09&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2021060420000033108\">Read 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