{"id":33022,"date":"2021-06-04T12:50:00","date_gmt":"2021-06-04T05:50:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021060412500033022"},"modified":"2021-06-05T21:38:01","modified_gmt":"2021-06-05T13:38:01","slug":"%e8%af%ba%e8%af%9a%e5%81%a5%e5%8d%8e%e5%9c%a8%e7%be%8e%e5%9b%bd%e4%b8%b4%e5%ba%8a%e8%82%bf%e7%98%a4%e5%ad%a6%e4%bc%9a%e5%b9%b4%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83%e6%b3%9bfgfr%e6%8a%91%e5%88%b6","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021060412500033022","title":{"rendered":"\u8bfa\u8bda\u5065\u534e\u5728\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u5e74\u4f1a\u4e0a\u516c\u5e03\u6cdbFGFR\u6291\u5236\u5242gunagratinib\u6700\u65b0\u4e34\u5e8a\u6570\u636e"},"content":{"rendered":"<p><p>\u5317\u4eac2021\u5e746\u67084\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u751f\u7269\u533b\u836f\u9ad8\u79d1\u6280\u516c\u53f8\u8bfa\u8bda\u5065\u534e\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a09969\uff09\u4eca\u5929\u57282021\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a(ASCO)\u5e74\u4f1a\u4e0a\u516c\u5e03\u6cdbFGFR\u6291\u5236\u5242ICP-192(gunagratinib)\u6700\u65b0\u4e34\u5e8a\u6570\u636e\u3002\u8fd9\u662fgunagratinib\u9996\u6b21\u5728\u56fd\u9645\u5b66\u672f\u4f1a\u8bae\u4e0a\u5c55\u793a\u4e34\u5e8a\u6570\u636e\uff0c\u663e\u793a\u4e86\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002<\/p>\n<p><b>\u5165\u9009\u7814\u7a76\uff1a<\/b><b>\u4e00\u79cd\u9ad8\u5ea6\u9009\u62e9\u6027\u7684\u4e0d\u53ef\u9006<\/b><b>FGFR\u6291\u5236\u5242ICP-192(<\/b><b>gunagratinib)<\/b><b>\u7528\u4e8e<\/b><b>FGFR\u57fa\u56e0\u5f02\u5e38\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u7684I\u671f\u4e34\u5e8a\u7ed3\u679c\uff08\u6458\u8981\u4ee3\u7801\uff1a<\/b>4092<b>\uff09\u3002<\/b><\/p>\n<p>\u8bfa\u8bda\u5065\u534e\u81ea\u4e3b\u7814\u53d1\u7684ICP-192(gunagratinib)\u662f\u4e00\u79cd\u65b0\u578b\u9ad8\u9009\u62e9\u6027\u7684\u6cdbFGFR\uff08\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff09\u6291\u5236\u5242\uff0c\u53ef\u901a\u8fc7\u5171\u4ef7\u7ed3\u5408\u4e0d\u53ef\u9006\u5730\u6291\u5236FGFR\u6d3b\u6027\uff0c\u4e5f\u53ef\u4ee5\u514b\u670d\u7b2c\u4e00\u4ee3\u53ef\u9006FGFR\u6291\u5236\u5242\u7684\u83b7\u5f97\u6027\u8010\u836f<span id=\"spanHghlte8ab\">\u3002<\/span><\/p>\n<p>Gunagratinib\u76ee\u524d\u6b63\u5904\u4e8e\u4e34\u5e8aI\/II\u671f\u9636\u6bb5\uff0c\u5e76\u8bc4\u4f30\u4e86\u8be5\u6291\u5236\u5242\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u4ee5\u53ca\u836f\u4ee3\u52a8\u529b\u5b66\/\u836f\u6548\u52a8\u529b\u5b66(PK \/ PD)\u7279\u6027\uff0c\u5e76\u91c7\u7528RECIST1.1\u6807\u51c6\u8bc4\u4f30FGF \/ FGFR\u57fa\u56e0\u7a81\u53d8\u60a3\u8005\u4e2d\u7684\u521d\u6b65\u7597\u6548\u3002<\/p>\n<p>\u622a\u81f32021\u5e742\u6708\uff0c\u5171\u670930\u540d\u60a3\u8005\u63a5\u53d7\u4e86gunagratinib\u6cbb\u7597\u3002\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\uff0c\u672a\u8fbe\u5230\u6700\u5927\u8010\u53d7\u5242\u91cf(MTD)\u3002\u5728\u5b8c\u6210\u81f3\u5c11\u4e00\u6b21\u80bf\u7624\u8bc4\u4f30\u768412\u540dFGF\/FGFR\u57fa\u56e0\u7a81\u53d8\u9633\u6027\u60a3\u8005\u4e2d\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387(ORR)\u4e3a33.3%\uff0c\u5305\u62ec1\u540d\u80c6\u7ba1\u764c\u60a3\u8005\uff08\u53608.3%\uff09\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3(CR)\uff0c3\u540d\u60a3\u8005\uff08\u536025%\uff09\u8fbe\u5230\u90e8\u5206\u7f13\u89e3(PR)\uff0c7\u540d\u60a3\u8005\u8fbe\u5230\u75be\u75c5\u7a33\u5b9a(SD)\u3002\u75be\u75c5\u63a7\u5236\u7387(DCR)\u4e3a91.7%\u3002<\/p>\n<p>\u4e0a\u6d77\u5e02\u4e1c\u65b9\u533b\u9662\u80bf\u7624\u533b\u5b66\u90e8\u526f\u4e3b\u4efb\u517c\u2160\u671f\u4e34\u5e8a\u4e2d\u5fc3\u4e3b\u4efb\u90ed\u6654\u6559\u6388\u8bf4\uff1a\u201c\u5728\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\uff0cgunagratinib\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\u3002\u5728\u9488\u5bf9\u80c6\u7ba1\u764c\u5728\u5185\u6709FGF\/FGFR\u57fa\u56e0\u7a81\u53d8\u7684\u591a\u79cd\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\uff0cgunagratinib\u5747\u8868\u73b0\u51fa\u6297\u80bf\u7624\u6d3b\u6027\u3002\u968f\u7740\u6cbb\u7597\u65f6\u95f4\u7684\u5ef6\u957f\uff0c\u9884\u671f\u4f1a\u6709\u66f4\u597d\u7684\u7597\u6548\u3002\u201d<\/p>\n<p>2021\u5e74ASCO\u5e74\u4f1a\u4e8e2021\u5e746\u67084\u65e5\u52308\u65e5\u5728\u7ebf\u4e3e\u529e\u3002ASCO\u5e74\u4f1a\u662f\u5168\u7403\u80bf\u7624\u9886\u57df\u6700\u91cd\u8981\u7684\u3001\u6700\u4e3a\u6743\u5a01\u7684\u5b66\u672f\u4ea4\u6d41\u76db\u4f1a\uff0c\u5c06\u5c55\u793a\u5f53\u524d\u56fd\u9645\u6700\u524d\u6cbf\u7684\u4e34\u5e8a\u80bf\u7624\u5b66\u79d1\u7814\u6210\u679c\u548c\u80bf\u7624\u6cbb\u7597\u6280\u672f\u3002<\/p>\n<p><b>\u5173\u4e8e\u8bfa\u8bda\u5065\u534e<\/b><\/p>\n<p>\u8bfa\u8bda\u5065\u534e\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a09969\uff09\u662f\u4e00\u5bb6\u5546\u4e1a\u5316\u9636\u6bb5\u7684\u751f\u7269\u533b\u836f\u9ad8\u79d1\u6280\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u6076\u6027\u80bf\u7624\u53ca\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u6cbb\u7597\u9886\u57df\u7684\u4e00\u7c7b\u65b0\u836f\u7814\u5236\uff0c\u9002\u7528\u4e8e\u4e2d\u56fd\u75c5\u4eba\u9ad8\u53d1\u7684\u6dcb\u5df4\u7624\u3001\u809d\u764c\u3001\u80c6\u7ba1\u764c\u3001\u5c3f\u8def\u4e0a\u76ae\u764c\u7b49\u591a\u79cd\u6076\u6027\u80bf\u7624\u53ca\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3002\u73b0\u6709\u591a\u4e2a\u65b0\u836f\u4ea7\u54c1\u5904\u4e8e\u5546\u4e1a\u5316\u3001\u4e34\u5e8a\u53ca\u4e34\u5e8a\u524d\u7814\u53d1\u9636\u6bb5\u3002\u516c\u53f8\u5728\u5317\u4eac\u3001\u5357\u4eac\u3001\u4e0a\u6d77\u3001\u5e7f\u5dde\u3001\u7f8e\u56fd\u65b0\u6cfd\u897f\u548c\u6ce2\u58eb\u987f\u5747\u8bbe\u6709\u5206\u652f\u673a\u6784\u3002<\/p>\n<p class=\"prntal\">\u76f8\u5173\u94fe\u63a5\uff1a<a target=\"_blank\" href=\"https:\/\/cn.innocarepharma.com\/cn\/\" rel=\"nofollow noopener\">https:\/\/cn.innocarepharma.com\/cn\/<\/a> <\/p>\n<div>\n<table cellspacing=\"0\" cellpadding=\"0\" border=\"0\" class=\"prntblns\">\n<tbody>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><b>\u8054\u7cfb\u4eba<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><b>\u6295\u8d44\u8005<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><b>\u5a92\u4f53<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen2\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u9646\u6625\u534e<\/span><\/p>\n<\/td>\n<td class=\"prngen2\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">86-10-66609879&nbsp;<\/span><\/p>\n<\/td>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">86-10-66609999<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><a target=\"_blank\" href=\"https:\/\/prnnj3-irisxe10.prnewswire.local\/ewebeditor\/\" class=\"prnews_a\" rel=\"nofollow noopener\">chunhua.lu@innocarepharma.com<\/a>&nbsp;<\/span><\/p>\n<\/td>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\"><a target=\"_blank\" href=\"https:\/\/prnnj3-irisxe10.prnewswire.local\/ewebeditor\/\" class=\"prnews_a\" rel=\"nofollow noopener\">ir@innocarepharma.com<\/a><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>\u76f8\u5173\u94fe\u63a5 :<\/p>\n<p>https:\/\/cn.innocarepharma.com\/cn\/<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5317\u4eac2021\u5e746\u67084\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u751f\u7269\u533b\u836f\u9ad8\u79d1\u6280\u516c\u53f8\u8bfa\u8bda\u5065\u534e\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u4ee3\u7801\uff1a09969\uff09\u4eca\u5929\u57282021\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a(ASCO)\u5e74\u4f1a\u4e0a\u516c\u5e03\u6cdbFGFR\u6291\u5236\u5242ICP-192(gunagratinib)\u6700\u65b0\u4e34\u5e8a\u6570\u636e\u3002\u8fd9\u662fgunagratinib\u9996\u6b21\u5728\u56fd\u9645\u5b66\u672f\u4f1a\u8bae\u4e0a\u5c55\u793a\u4e34\u5e8a\u6570\u636e\uff0c\u663e\u793a\u4e86\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002 \u5165\u9009\u7814\u7a76\uff1a\u4e00\u79cd\u9ad8\u5ea6\u9009\u62e9\u6027\u7684\u4e0d\u53ef\u9006FGFR\u6291\u5236\u5242ICP-192(gunagratinib)\u7528\u4e8eFGFR\u57fa\u56e0\u5f02\u5e38\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u7684I\u671f\u4e34\u5e8a\u7ed3\u679c\uff08\u6458\u8981\u4ee3\u7801\uff1a4092\uff09\u3002 \u8bfa\u8bda\u5065\u534e\u81ea\u4e3b\u7814\u53d1\u7684ICP-192(gunagratinib)\u662f\u4e00\u79cd\u65b0\u578b\u9ad8\u9009\u62e9\u6027\u7684\u6cdbFGFR\uff08\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff09\u6291\u5236\u5242\uff0c\u53ef\u901a\u8fc7\u5171\u4ef7\u7ed3\u5408\u4e0d\u53ef\u9006\u5730\u6291\u5236FGFR\u6d3b\u6027\uff0c\u4e5f\u53ef\u4ee5\u514b\u670d\u7b2c\u4e00\u4ee3\u53ef\u9006FGFR\u6291\u5236\u5242\u7684\u83b7\u5f97\u6027\u8010\u836f\u3002 Gunagratinib\u76ee\u524d\u6b63\u5904\u4e8e\u4e34\u5e8aI\/II\u671f\u9636\u6bb5\uff0c\u5e76\u8bc4\u4f30\u4e86\u8be5\u6291\u5236\u5242\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u4ee5\u53ca\u836f\u4ee3\u52a8\u529b\u5b66\/\u836f\u6548\u52a8\u529b\u5b66(PK \/ PD)\u7279\u6027\uff0c\u5e76\u91c7\u7528RECIST1.1\u6807\u51c6\u8bc4\u4f30FGF \/ FGFR\u57fa\u56e0\u7a81\u53d8\u60a3\u8005\u4e2d\u7684\u521d\u6b65\u7597\u6548\u3002 \u622a\u81f32021\u5e742\u6708\uff0c\u5171\u670930\u540d\u60a3\u8005\u63a5\u53d7\u4e86gunagratinib\u6cbb\u7597\u3002\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\uff0c\u672a\u8fbe\u5230\u6700\u5927\u8010\u53d7\u5242\u91cf(MTD)\u3002\u5728\u5b8c\u6210\u81f3\u5c11\u4e00\u6b21\u80bf\u7624\u8bc4\u4f30\u768412\u540dFGF\/FGFR\u57fa\u56e0\u7a81\u53d8\u9633\u6027\u60a3\u8005\u4e2d\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387(ORR)\u4e3a33.3%\uff0c\u5305\u62ec1\u540d\u80c6\u7ba1\u764c\u60a3\u8005\uff08\u53608.3%\uff09\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3(CR)\uff0c3\u540d\u60a3\u8005\uff08\u536025%\uff09\u8fbe\u5230\u90e8\u5206\u7f13\u89e3(PR)\uff0c7\u540d\u60a3\u8005\u8fbe\u5230\u75be\u75c5\u7a33\u5b9a(SD)\u3002\u75be\u75c5\u63a7\u5236\u7387(DCR)\u4e3a91.7%\u3002 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