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target=\"_blank\" href=\"http:\/\/ir.beigene.com\/\" rel=\"nofollow noopener\">http:\/\/ir.beigene.com<\/a>&nbsp;\u6216&nbsp;<a target=\"_blank\" href=\"http:\/\/hkexir.beigene.com\/\" rel=\"nofollow noopener\">http:\/\/hkexir.beigene.com<\/a>\uff09\u6536\u770b\u672c\u6b21\u7535\u8bdd\u4f1a\u8bae\u7684\u5728\u7ebf\u76f4\u64ad\u3002\u4f1a\u8bae\u7ed3\u675f\u4e24\u5c0f\u65f6\u540e\uff0c\u53ef\u572890\u5929\u5185\u8bbf\u95ee\u5b98\u7f51\u6295\u8d44\u4eba\u7248\u5757\u89c2\u770b\u89c6\u9891\u56de\u653e\u3002<\/p>\n<p><b>\u5173\u4e8e<\/b><b>ALPINE<\/b><b>\u4e34\u5e8a\u8bd5\u9a8c<\/b><\/p>\n<p>ALPINE\u662f\u4e00\u9879\u968f\u673a\u5168\u74033\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT03734016\uff09\uff0c\u65e8\u5728\u8bc4\u4f30\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5bf9\u6bd4\u4f0a\u5e03\u66ff\u5c3c\u7528\u4e8e\u6cbb\u7597\u5148\u524d\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\uff08R\/R\uff09\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u6216\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08SLL\uff09\u60a3\u8005\u3002&nbsp;<\/p>\n<p>\u8be5\u8bd5\u9a8c\u4e2d\uff0c652\u4f8b\u60a3\u8005\u88ab\u968f\u673a\u81f3\u4e24\u4e2a\u8bd5\u9a8c\u7ec4\u63a5\u53d7\u6cbb\u7597\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u63a5\u53d7\u6bd2\u6027\uff1b\u4e00\u4e2a\u8bd5\u9a8c\u81c2\u4e2d\u7684\u60a3\u8005\u63a5\u53d7\u5242\u91cf\u4e3a\u6bcf\u6b21160 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mg\u3001\u6bcf\u65e5\u4e00\u6b21\u7684\u4f0a\u5e03\u66ff\u5c3c\u6cbb\u7597\u3002\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u7684\u4e3b\u8981\u7ec8\u70b9\u5b9a\u4e49\u4e3a\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5bf9\u6bd4\u4f0a\u5e03\u66ff\u5c3c\u8fbe\u5230\u9884\u5148\u8bbe\u5b9a\u7684\u975e\u52a3\u6548\u6027\u3002\u7814\u7a76\u8005\u53ca\u72ec\u7acb\u5ba1\u67e5\u59d4\u5458\u4f1a\uff08IRC\uff09\u57fa\u4e8e\u56fd\u9645\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u5de5\u4f5c\u7ec4\uff08iwCLL\uff09\u6307\u5bfc\u539f\u5219\uff082008\u5e74\u4fee\u8ba2\u7248\uff09\u8bc4\u4f30CLL\u60a3\u8005\u7684\u7f13\u89e3\uff08\u4f46\u9488\u5bf9\u6cbb\u7597\u76f8\u5173\u6dcb\u5df4\u7ec6\u80de\u589e\u591aCLL\u60a3\u8005\u7684\u8bc4\u4ef7\u6807\u51c6\u6709\u6240\u8c03\u6574\uff09\uff0c\u4ee5\u53caLugano\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u5206\u7c7b\u6807\u51c6\u8bc4\u4f30SLL\u60a3\u8005\u7684\u7f13\u89e3\u3002\u7ecf\u7814\u7a76\u8005\u548cIRC\u8bc4\u4f30\u7684ORR\u5c06\u91c7\u7528\u5206\u7ea7\u6d4b\u8bd5\uff0c\u9996\u5148\u8bc4\u4f30\u975e\u52a3\u6548\u6027\uff0c\u968f\u540e\u8bc4\u4f30\u4f18\u6548\u6027\u3002\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3001\u6301\u7eed\u7f13\u89e3\u65f6\u95f4\uff08DoR\uff09\u3001\u603b\u751f\u5b58\u671f\uff08OS\uff09\u4ee5\u53ca\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u3002\u8be5\u9879\u8bd5\u9a8c\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u4e2d\uff0c\u8ba1\u5212\u7684\u6700\u7ec8\u5206\u6790\u9884\u8ba1\u57282022\u5e74\u8fdb\u884c\u3002\u5c4a\u65f6\uff0c\u4e5f\u5c06\u5bf9\u9884\u5148\u8bbe\u5b9a\u7684ORR\u4ee5\u53caPFS\u8bd5\u9a8c\u7ec8\u70b9\u8fdb\u884c\u5206\u6790\u3002<\/p>\n<p><b>\u5173\u4e8e\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u548c\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624<\/b><\/p>\n<p>\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u662f\u6210\u5e74\u4eba\u4e2d\u6700\u5e38\u89c1\u7684\u4e00\u79cd\u767d\u8840\u75c5\uff0c\u57282017\u5e74\uff0c\u5168\u7403\u8303\u56f4\u5185\u7ea6\u6709114000\u8d77\u65b0\u589e\u75c5\u4f8b<sup>[1],[2]<\/sup>\u3002CLL\u5bfc\u81f4\u60a3\u8005\u9aa8\u9ad3\u4e2d\u7684\u767d\u7ec6\u80de\u53ca\u6dcb\u5df4\u7ec6\u80de\u6301\u7eed\u589e\u591a\uff0c\u800c\u80bf\u7624\u7ec6\u80de\u5728\u9aa8\u9ad3\u4e2d\u4e0d\u65ad\u589e\u6b96\u5c06\u524a\u5f31\u60a3\u8005\u62b5\u6297\u611f\u67d3\u7684\u80fd\u529b\uff0c\u5e76\u80fd\u591f\u8fdb\u5165\u60a3\u8005\u8840\u6db2\uff0c\u4ece\u800c\u6d78\u6da6\u81f3\u6dcb\u5df4\u7ed3\u3001\u809d\u810f\u3001\u813e\u810f\u53ca\u8eab\u4f53\u5176\u5b83\u5668\u5b98<sup>[1],[3]<\/sup>BTK\u901a\u8def\u662f\u6076\u6027B\u7ec6\u80de\u4f20\u5bfc\u4fe1\u53f7\u7684\u91cd\u8981\u4ecb\u8d28\uff0c\u80fd\u591f\u4fc3\u8fdbCLL\u53d1\u75c5<sup>[4]<\/sup>\u3002\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08SLL\uff09\u662f\u4e00\u79cd\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff0c\u4e3b\u8981\u5f71\u54cd\u514d\u75ab\u7cfb\u7edf\u4e2d\u7684B\u6dcb\u5df4\u7ec6\u80de\u3002SLL\u4e0eCLL\u76f8\u4f3c\uff0c\u4f46\u80bf\u7624\u7ec6\u80de\u4e3b\u8981\u84c4\u79ef\u4e8e\u6dcb\u5df4\u7ed3\u4e2d<sup>[5]<\/sup>\u3002<\/p>\n<p><b>\u5173\u4e8e\u767e\u60a6\u6cfd<\/b><b><sup>&reg;<\/sup><\/b><b>\uff08\u6cfd\u5e03\u66ff\u5c3c\uff09<\/b><b>&nbsp;<\/b><\/p>\n<p>\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\uff08\u6cfd\u5e03\u66ff\u5c3c\uff09\u662f\u4e00\u6b3e\u7531\u767e\u6d4e\u795e\u5dde\u79d1\u5b66\u5bb6\u81ea\u4e3b\u7814\u53d1\u7684\u5e03\u9c81\u987f\u6c0f\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff0c\u76ee\u524d\u6b63\u5728\u5168\u7403\u8fdb\u884c\u5e7f\u6cdb\u7684\u4e34\u5e8a\u8bd5\u9a8c\u9879\u76ee\uff0c\u4f5c\u4e3a\u5355\u836f\u548c\u4e0e\u5176\u4ed6\u7597\u6cd5\u8fdb\u884c\u8054\u5408\u7528\u836f\u6cbb\u7597\u591a\u79cd&nbsp;B 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type=\"disc\">\n<li>2019\u5e7411\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u7f8e\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u9879\u7597\u6cd5\u7684\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u60a3\u8005*&nbsp; <\/li>\n<li>2020\u5e746\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u5e74\u5957\u7ec6\u80de\u6dcb\u5df4\u7624&nbsp;\uff08MCL\uff09\u60a3\u8005** <\/li>\n<li>2020\u5e746\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u4e2d\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6210\u5e74\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08SLL\uff09&nbsp;\u60a3\u8005&nbsp; <\/li>\n<li>2021\u5e742\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u963f\u62c9\u4f2f\u8054\u5408\u914b\u957f\u56fd\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u6027MCL\u60a3\u8005&nbsp; <\/li>\n<li>2021\u5e743\u6708\uff0c\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u5728\u52a0\u62ff\u5927\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u534e\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u6210\u5e74\u60a3\u8005&nbsp;<\/li>\n<\/ul>\n<p>\u76ee\u524d\uff0c\u9664\u7f8e\u56fd\u548c\u4e2d\u56fd\u4ee5\u5916\uff0c\u5171\u670930\u591a\u9879\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u9488\u5bf9\u591a\u9879\u9002\u5e94\u75c7\u7684\u76f8\u5173\u4e0a\u5e02\u7533\u8bf7\u5b8c\u6210\u9012\u4ea4\u5de5\u4f5c\uff0c\u8986\u76d6\u6b27\u76df\u4ee5\u53ca\u5176\u4ed620\u591a\u4e2a\u56fd\u5bb6\u3002&nbsp;<\/p>\n<p>*\u8be5\u9879\u9002\u5e94\u75c7\u57fa\u4e8e\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\u83b7\u5f97\u52a0\u901f\u6279\u51c6\u3002\u9488\u5bf9\u8be5\u9002\u5e94\u75c7\u7684\u5b8c\u5168\u6279\u51c6\u5c06\u53d6\u51b3\u4e8e\u9a8c\u8bc1\u6027\u8bd5\u9a8c\u4e2d\u4e34\u5e8a\u76ca\u5904\u7684\u9a8c\u8bc1\u548c\u63cf\u8ff0\u3002&nbsp;<\/p>\n<p>**\u8be5\u9879\u9002\u5e94\u75c7\u83b7\u9644\u6761\u4ef6\u6279\u51c6\u3002\u9488\u5bf9\u8be5\u9002\u5e94\u75c7\u7684\u5b8c\u5168\u6279\u51c6\u5c06\u53d6\u51b3\u4e8e\u6b63\u5728\u5f00\u5c55\u7684\u786e\u8bc1\u6027\u968f\u673a\u3001\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u3002<\/p>\n<p><b>\u5173\u4e8e\u767e\u6d4e\u795e\u5dde\u80bf\u7624\u5b66<\/b><\/p>\n<p>\u767e\u6d4e\u795e\u5dde\u901a\u8fc7\u81ea\u4e3b\u7814\u53d1\u6216\u4e0e\u5fd7\u540c\u9053\u5408\u7684\u5408\u4f5c\u4f19\u4f34\u643a\u624b\uff0c\u4e0d\u65ad\u63a8\u52a8\u540c\u7c7b\u6700\u4f73\u6216\u540c\u7c7b\u7b2c\u4e00\u7684\u4e34\u5e8a\u5019\u9009\u836f\u7269\u7814\u53d1\uff0c\u81f4\u529b\u4e8e\u4e3a\u5168\u7403\u60a3\u8005\u63d0\u4f9b\u6709\u5f71\u54cd\u529b\u3001\u53ef\u53ca\u4e14\u53ef\u8d1f\u62c5\u7684\u836f\u7269\u3002\u516c\u53f8\u5168\u7403\u4e34\u5e8a\u7814\u7a76\u548c\u5f00\u53d1\u56e2\u961f\u5df2\u6709\u7ea62300\u4eba\uff0c\u56e2\u961f\u89c4\u6a21\u8fd8\u5728\u4e0d\u65ad\u6269\u5927\u3002\u8fd9\u652f\u56e2\u961f\u76ee\u524d\u6b63\u5728\u5168\u7403\u8303\u56f4\u652f\u6301\u5f00\u5c5590 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noopener\">www.beigene.com.cn<\/a>\u3002<\/p>\n<p><b>\u524d\u77bb\u6027\u58f0\u660e<\/b><\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u5305\u542b\u6839\u636e\u300a1995 \u5e74\u79c1\u4eba\u8bc1\u5238\u8bc9\u8bbc\u6539\u9769\u6cd5\u6848\u300b\uff08Private Securities Litigation Reform Act of 1995\uff09\u4ee5\u53ca\u5176\u4ed6\u8054\u90a6\u8bc1\u5238\u6cd5\u5f8b\u4e0b\u5b9a\u4e49\u7684\u524d\u77bb\u6027\u58f0\u660e\uff0c\u5305\u62ec\u5173\u4e8e\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u80fd\u591f\u4e3a\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u60a3\u8005\u6539\u5584\u6f5c\u5728\u4e34\u5e8a\u83b7\u76ca\u4ee5\u53ca\u767e\u60a6\u6cfd<sup>&reg;<\/sup>\u6709\u671b\u6210\u4e3a\u540c\u7c7b\u6700\u4f73BTK\u6291\u5236\u5242\u7684\u58f0\u660e\uff0cALPINE 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cellspacing=\"0\" cellpadding=\"0\" border=\"0\" class=\"prntblns\">\n<tbody>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">1. American Cancer Society. Cancer Facts &amp; Figures 2021. Atlanta; American Cancer Society; 2021. Available here: <u><a target=\"_blank\" href=\"https:\/\/protect-us.mimecast.com\/s\/nfCrCZ6y6LTo11Pzszkphz?domain=cancer.org\" class=\"prnews_a\" rel=\"nofollow noopener\">Cancer Facts and Figures 2021<\/a><\/u> <\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">2. Global Burden of Disease Cancer Collaboration. Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017. JAMA Oncol. 2019;5(12):1749-1768. <\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">3. National Cancer Institute. Chronic Lymphocytic Leukemia Treatment (PDQ&reg;)\u2013Patient Version. Available here: <u><a target=\"_blank\" href=\"https:\/\/protect-us.mimecast.com\/s\/9YH2C1wqwyHErrn8sGx8yy?domain=cancer.gov\" class=\"prnews_a\" rel=\"nofollow noopener\">Chronic Lymphocytic Leukemia Treatment (PDQ&reg;)\u2013Patient Version<\/a><\/u><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">4. Haselager MV et al. Proliferative Signals in Chronic Lymphocytic Leukemia; What Are We Missing? Front Oncol. 2020; 10: 592205. <\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">5. Cancer Support Community. Chronic Lymphocytic Leukemia\/Small Lymphocytic Lymphoma. Available here: <u><a target=\"_blank\" href=\"https:\/\/www.cancersupportcommunity.org\/chronic-lymphocytic-leukemiasmall-lymphocytic-lymphoma\" class=\"prnews_a\" rel=\"nofollow noopener\">https:\/\/www.cancersupportcommunity.org\/chronic-lymphocytic-leukemiasmall-lymphocytic-lymphoma<\/a><\/u>. <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>&nbsp;<\/p>\n\n<p>\u76f8\u5173\u94fe\u63a5 :<\/p>\n<p>http:\/\/www.beigene.com<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5728\u6309\u8ba1\u5212\u8fdb\u884c\u7684\u671f\u4e2d\u5206\u6790\u4e2d\uff0c\u7ecf\u7814\u7a76\u8005\u8bc4\u4f30\uff0c\u767e\u60a6\u6cfd&reg;\u8fbe\u5230\u5ba2\u89c2\u7f13\u89e3\u7387\u4f18\u6548\u6027 \u767e\u60a6\u6cfd&reg;\u5f15\u8d77\u623f\u98a4\u6216\u623f\u6251\u7684\u98ce\u9669\u964d\u4f4e\uff0c\u5dee\u5f02\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49 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