{"id":30297,"date":"2021-05-17T19:20:00","date_gmt":"2021-05-17T12:20:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021051719200030297"},"modified":"2021-05-17T21:41:09","modified_gmt":"2021-05-17T13:41:09","slug":"%e5%be%b7%e7%90%aa%e5%8c%bb%e8%8d%af%e4%b8%8ecalithera-biosciences%e8%be%be%e6%88%90cd73%e6%8a%91%e5%88%b6%e5%89%82cb-708-atg-037%e5%bc%80%e5%8f%91%e5%92%8c%e5%95%86%e4%b8%9a%e5%8c%96%e7%9a%84","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021051719200030297","title":{"rendered":"\u5fb7\u742a\u533b\u836f\u4e0eCalithera Biosciences\u8fbe\u6210CD73\u6291\u5236\u5242CB-708 (ATG-037)\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u7684\u5168\u7403\u72ec\u5bb6\u6388\u6743\u534f\u8bae"},"content":{"rendered":"\n\n\n
\"\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

–\u5fb7\u742a\u533b\u836f\u5c06\u8d1f\u8d23\u63a8\u52a8CD73\u6291\u5236\u5242CB-708 (ATG-037)\u5728\u5168\u7403\u8303\u56f4\u7684\u5f00\u53d1\u4e0e\u5546\u4e1a\u5316<\/i><\/b><\/p>\n

—<\/i><\/b> Calithera\u516c\u53f8\u5c06\u83b7\u5f97\u9996\u4ed8\u6b3e\u3001\u6f5c\u5728\u7684\u91cc\u7a0b\u7891\u4ed8\u6b3e\u4ee5\u53ca\u5206\u7ea7\u7279\u8bb8\u6743\u4f7f\u7528\u8d39<\/i><\/b><\/p>\n

\u4e0a\u6d77\u548c\u5357\u65e7\u91d1\u5c71<\/span>2021\u5e745\u670817\u65e5 \/\u7f8e\u901a\u793e\/ — \u81f4\u529b\u4e8e\u7814\u53d1\u548c\u5546\u4e1a\u5316\u521b\u65b0\u80bf\u7624\u7597\u6cd5\u7684\u9886\u5148\u751f\u7269\u5236\u836f\u516c\u53f8 — \u5fb7\u742a\u533b\u836f\u6709\u9650\u516c\u53f8\uff08\u7b80\u79f0\u201c\u5fb7\u742a\u533b\u836f\u201d\uff0c\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a6996.HK\uff09\u4e0e\u4e13\u6ce8\u4e8e\u5f00\u53d1\u6cbb\u7597\u80bf\u7624\u7b49\u5371\u53ca\u751f\u547d\u75be\u75c5\u7684\u65b0\u578b\u5c0f\u5206\u5b50\u836f\u7269\u7684\u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u6280\u672f\u516c\u53f8 — Calithera Biosciences, Inc.\uff08\u7b80\u79f0\u201cCalithera\u201d \uff0c\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aCALA\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u4e24\u5bb6\u516c\u53f8\u5c31\u4e00\u6b3eCD73\u5c0f\u5206\u5b50\u6291\u5236\u5242 — CB-708\uff08ATG-037\uff09\uff0c\u5728\u5168\u7403\u8303\u56f4\u7684\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u8fbe\u6210\u72ec\u5bb6\u6388\u6743\u534f\u8bae\u3002<\/p>\n

\n<\/p><\/div>\n

\u6839\u636e\u8be5\u534f\u8bae\uff0cCalithera\u5c06\u83b7\u5f97\u4e00\u7b14\u9996\u4ed8\u6b3e\u4ee5\u53ca\u57fa\u4e8e\u5f00\u53d1\u3001\u6ce8\u518c\u548c\u9500\u552e\u8fdb\u5c55\u7684\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u5e76\u6709\u8d44\u683c\u5728\u6388\u6743\u4ea7\u54c1\u7684\u9500\u552e\u6536\u5165\u4e2d\u83b7\u5f97\u5341\u51e0\u4e2a\u767e\u5206\u70b9\u4e4b\u5185\u7684\u5206\u7ea7\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002<\/p>\n

CD73\u53ef\u4ea7\u751f\u5177\u6709\u9ad8\u5ea6\u514d\u75ab\u6291\u5236\u4f5c\u7528\u7684\u817a\u82f7\uff0c\u5b83\u901a\u8fc7\u4e0b\u8c03IFN-\u03b3\uff0c\u6291\u5236NK\u7ec6\u80de\u548cCD8+ T\u7ec6\u80de\u7684\u6d3b\u6027\u6765\u589e\u5f3a\u764c\u7ec6\u80de\u7684\u589e\u6b96\u3002\u80bf\u7624\u53ef\u4ee5\u901a\u8fc7\u591a\u4e2aCD73\u4ecb\u5bfc\u901a\u8def\u9003\u907f\u514d\u75ab\u53cd\u5e94\u3002\u56e0\u6b64\uff0c\u6709\u6548\u5730\u963b\u65adCD73\u9776\u70b9\u662f\u6062\u590d\u764c\u75c7\u60a3\u8005\u514d\u75ab\u80fd\u529b\u7684\u4e00\u4e2a\u6709\u6548\u9014\u5f84\u3002\u6b64\u5916\uff0cCD73\u9776\u70b9\u963b\u65ad\u8fd8\u4e0e\u5e38\u89c4\u7597\u6cd5\u548c\u5176\u5b83\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5177\u6709\u5f3a\u5927\u7684\u534f\u540c\u6f5c\u529b\u3002CB-708\u662f\u4e00\u6b3e\u9ad8\u6548\u3001\u9ad8\u9009\u62e9\u6027\u7684\u53e3\u670dCD73\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff0c\u6709\u671b\u5728\u6cbb\u7597\u591a\u79cd\u80bf\u7624\u7684\u5355\u836f\u6216\u8054\u5408\u7597\u6cd5\u4e2d\u91ca\u653e\u5de8\u5927\u6f5c\u529b\u3002<\/p>\n

\u6839\u636e2019\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\uff08AACR\uff09\u5e74\u4f1a\u548c2019\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u534f\u4f1a\uff08SITC\uff09\u5e74\u4f1a\u4e0a\u516c\u5e03\u7684\u4e34\u5e8a\u524d\u6570\u636e\uff0cCB-708\u5355\u836f\u5728\u5c0f\u9f20\u540c\u7cfb\u80bf\u7624\u6a21\u578b\u4e2d\u5177\u6709\u514d\u75ab\u4ecb\u5bfc\u6d3b\u6027\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u663e\u793a\uff0cCB-708\u8010\u53d7\u6027\u826f\u597d\uff0c\u540c\u65f6\u4e0e\u6297PD-L1\u514d\u75ab\u7597\u6cd5\u6216\u5316\u7597\u836f\u7269\uff08\u5982\u5965\u6c99\u5229\u94c2\u548c\u963f\u9709\u7d20\uff09\u8054\u7528\u65f6\u663e\u793a\u51fa\u66f4\u5f3a\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002CB-708\u5df2\u7ecf\u5b8c\u6210\u836f\u54c1\u975e\u4e34\u5e8a\u7814\u7a76\u8d28\u91cf\u7ba1\u7406\u89c4\u8303\uff08GLP\uff09\u7684\u6bd2\u7406\u5b66\u7814\u7a76\uff0c\u5e76\u5373\u5c06\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\u3002<\/p>\n

\u5fb7\u742a\u533b\u836f\u521b\u59cb\u4eba\u3001\u9996\u5e2d\u6267\u884c\u5b98\u6885\u5efa\u660e\u535a\u58eb\u8868\u793a\uff1a\u201c\u51ed\u501f\u5fb7\u742a\u533b\u836f\u56e2\u961f\u5728\u5168\u7403\u4e3b\u8981\u5e02\u573a\u7684\u4e34\u5e8a\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u7684\u4e30\u5bcc\u7ecf\u9a8c\uff0c\u6211\u4eec\u5f88\u9ad8\u5174\u6709\u673a\u4f1a\u63a8\u8fdbCB-708\u7684\u5f00\u53d1\u3002CB-708\u5177\u6709\u53e3\u670d\u7279\u6027\u4e0e\u9ad8\u6d3b\u6027\uff0c\u662f\u4e00\u6b3e\u5177\u6709\u540c\u7c7b\u6700\u4f18\u6f5c\u529b\u7684\u9ad8\u5dee\u5f02\u5316CD73\u5c0f\u5206\u5b50\u53e3\u670d\u6291\u5236\u5242\u3002\u6b64\u5916\uff0cCB-708\u8fd8\u53ef\u4ee5\u514b\u670d\u6297CD73\u6297\u4f53\u5728\u6cbb\u7597\u4e2d\u4ea7\u751f\u7684\u2018\u94a9\u72b6\u6548\u5e94\u2019\uff0c\u5e76\u5728\u4f53\u5916\u6a21\u578b\u4e2d\u5b8c\u5168\u963b\u65adCD73\u3002\u5fb7\u742a\u533b\u836f\u672a\u6765\u5c06\u542f\u52a8CB-708\u7684GMP\u751f\u4ea7\uff0c\u5e76\u9488\u5bf9\u5b9e\u4f53\u7624\u3001\u8840\u6db2\u7624\u7b49\u591a\u79cd\u80bf\u7624\u5f00\u5c55\u4e34\u5e8a\u7814\u7a76\u3002\u6b64\u6b21\u5408\u4f5c\uff0c\u8fdb\u4e00\u6b65\u5f3a\u5316\u4e86\u6211\u4eec\u5177\u6709\u534f\u540c\u6f5c\u529b\u768412\u6b3e\u5019\u9009\u836f\u7269\u7684\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u518d\u4e00\u6b21\u4f53\u73b0\u4e86\u516c\u53f8\u5728\u5168\u7403\u5f00\u53d1\u65b9\u9762\u7684\u5b9e\u529b\uff0c\u53ef\u4ee5\u8bf4\uff0c\u6211\u4eec\u5728\u5b9e\u73b0\u2018\u533b\u8005\u65e0\u7586\uff0c\u521b\u65b0\u6c38\u7eed\u2019\u8fd9\u4e00\u4f7f\u547d\u7684\u5f81\u9014\u4e0a\u53c8\u8fc8\u51fa\u4e86\u4e00\u5927\u6b65\u3002\u201d<\/p>\n

Calithera\u516c\u53f8\u603b\u88c1\u53ca\u9996\u5e2d\u6267\u884c\u5b98Susan Molineaux\u535a\u58eb\u8bc4\u8bba\u9053\uff1a\u201c\u8fd9\u6b21\u5408\u4f5c\u4f53\u73b0\u4e86\u6211\u4eec\u836f\u7269\u7814\u53d1\u7684\u5f3a\u5927\u5b9e\u529b\uff0c\u4e5f\u662fCD73\u5f00\u53d1\u9879\u76ee\u7684\u4e00\u4e2a\u91cd\u8981\u91cc\u7a0b\u7891\u3002\u5fb7\u742a\u533b\u836f\u5bf9CB-708\u8fd9\u6b3e\u5177\u6709\u540c\u7c7b\u6700\u4f18\u6f5c\u529b\u7684CD73\u5c0f\u5206\u5b50\u53e3\u670d\u6291\u5236\u5242\u8868\u73b0\u51fa\u4e86\u6781\u5927\u70ed\u60c5\uff0c\u5e76\u5c06\u8d21\u732e\u5176\u5728\u5168\u7403\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u65b9\u9762\u7684\u4e30\u5bcc\u7ecf\u9a8c\u3002\u6b64\u6b21\u5408\u4f5c\u4e3aCB-708\u8fd9\u9879\u6781\u5177\u6f5c\u529b\u7684\u5f00\u53d1\u9879\u76ee\u94fa\u5e73\u4e86\u9053\u8def\uff0c\u540c\u65f6\u4e5f\u8ba9Calithera\u5f97\u4ee5\u96c6\u4e2d\u8d44\u6e90\u63a8\u8fdb\u9488\u5bf9telaglenastat\u7528\u4e8e\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4ee5\u53caCB-280\u7528\u4e8e\u6cbb\u7597\u56ca\u80de\u6027\u7ea4\u7ef4\u75c7\u7684\u4e2d\u671f\u4e34\u5e8a\u5f00\u53d1\u3002\u201d <\/b><\/p>\n

\u5173\u4e8e\u5fb7\u742a\u533b\u836f<\/b><\/p>\n

\u5fb7\u742a\u533b\u836f\u6709\u9650\u516c\u53f8\uff08\u7b80\u79f0\u201c\u5fb7\u742a\u533b\u836f\u201d\uff0c\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a6996.HK\uff09\u662f\u4e00\u5bb6\u4ee5\u7814\u53d1\u4e3a\u9a71\u52a8\u7684\u751f\u7269\u5236\u836f\u9886\u5148\u4f01\u4e1a\uff0c\u81f4\u529b\u4e8e\u4e3a\u4e9a\u592a\u4e43\u81f3\u5168\u7403\u60a3\u8005\u63d0\u4f9b\u6700\u9886\u5148\u7684\u7597\u6cd5\uff0c\u6cbb\u7597\u80bf\u7624\u53ca\u5176\u4ed6\u5371\u53ca\u751f\u547d\u7684\u75be\u75c5\u3002\u81ea2017\u5e74\u6b63\u5f0f\u8fd0\u8425\u4ee5\u6765\uff0c\u5fb7\u742a\u533b\u836f\u901a\u8fc7\u5408\u4f5c\u5f15\u8fdb\u548c\u81ea\u4e3b\u7814\u53d1\uff0c\u5efa\u7acb\u4e86\u4e00\u6761\u4ece\u4e34\u5e8a\u524d\u5230\u4e34\u5e8a\u9636\u6bb5\u7684\u4e0d\u65ad\u5ef6\u5c55\u7684\u4e30\u5bcc\u4ea7\u54c1\u7ba1\u7ebf\u3002\u76ee\u524d\uff0c\u5fb7\u742a\u533b\u836f\u5df2\u5728\u591a\u4e2a\u4e9a\u592a\u5e02\u573a\u83b7\u5f9715\u4e2a\u4e34\u5e8a\u6279\u4ef6\uff08IND\uff09\uff0c\u5e76\u9012\u4ea4\u4e865\u4e2a\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\uff08NDA\uff09\u3002\u5fb7\u742a\u533b\u836f\u5c06\u4ee5\u201c\u533b\u8005\u65e0\u7586\uff0c\u521b\u65b0\u6c38\u7eed\u201d\u4e3a\u613f\u666f\uff0c\u4e13\u6ce8\u4e8e\u540c\u7c7b\u9996\u6b3e\u548c\u540c\u7c7b\u6700\u4f18\u7597\u6cd5\u7684\u65e9\u671f\u7814\u53d1\u3001\u4e34\u5e8a\u7814\u7a76\u3001\u836f\u7269\u751f\u4ea7\u53ca\u5546\u4e1a\u5316\uff0c\u89e3\u51b3\u4e9f\u5f85\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\uff0c\u6b32\u4e86\u89e3\u66f4\u591a\uff0c\u8bf7\u8bbf\u95eewww.antengene.com<\/a>\u3002<\/p>\n

\u5173\u4e8e<\/b>Calithera Biosciences<\/b><\/p>\n

Calithera Biosciences\u662f\u4e00\u5bb6\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u3002Calithera\u81f4\u529b\u4e8e\u5f00\u53d1\u53ef\u901a\u8fc7\u963b\u65ad\u7ec6\u80de\u4ee3\u8c22\u901a\u8def\u9965\u997f\u80bf\u7624\u7ec6\u80de\u5e76\u5f3a\u5316\u514d\u75ab\u7ec6\u80de\u6d3b\u6027\u7684\u9776\u5411\u836f\u7269\u3002\u79c9\u6301\u5bf9\u79d1\u5b66\u7684\u4e25\u8c28\u6001\u5ea6\u548c\u4e3a\u80bf\u7624\u53ca\u5176\u4ed6\u5371\u53ca\u751f\u547d\u75be\u75c5\u7684\u60a3\u8005\u6539\u5584\u751f\u5b58\u8d28\u91cf\u7684\u627f\u8bfa\uff0cCalithera\u6b63\u5728\u63a8\u52a8\u591a\u4e2a\u540c\u7c7b\u9996\u521b\u53e3\u670d\u836f\u7269\u7684\u5f00\u53d1\uff0c\u4ee5\u6b64\u4e3a\u60a3\u8005\u63d0\u4f9b\u66f4\u591a\u7684\u6cbb\u7597\u9009\u62e9\u3002Calithera\u7684\u603b\u90e8\u4f4d\u4e8e\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u5357\u5723\u5f17\u6717\u897f\u65af\u79d1\u3002\u6709\u5173Calithera\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95eewww.calithera.com<\/a>\u3002<\/p>\n

\u524d\u77bb\u6027\u9648\u8ff0<\/b><\/p>\n

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<\/div>\n

\u76f8\u5173\u94fe\u63a5 :<\/p>\n

http:\/\/www.antengene.com<\/p>\n","protected":false},"excerpt":{"rendered":"

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