\u7f8e\u56fd\u65e7\u91d1\u5c71\u548c\u4e2d\u56fd\u82cf\u5dde2021\u5e744\u670829\u65e5 \/\u7f8e\u901a\u793e\/ — \u4fe1\u8fbe\u751f\u7269\u5236\u836f\uff08\u9999\u6e2f\u8054\u4ea4\u6240\u80a1\u7968\u4ee3\u7801\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8c22\u3001\u773c\u79d1\u75be\u75c5\u7b49\u91cd\u5927\u75be\u75c5\u7684\u521b\u65b0\u836f\u7269\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u5ba3\u5e03\uff0c\u5176\u5168\u7403\u9996\u521b\u773c\u79d1\u6297VEGF-\u8865\u4f53\u53cc\u9776\u70b9\u836f\u7269\uff08\u7814\u53d1\u4ee3\u53f7\uff1aIBI302\uff09\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7ed9\u836f\u3002<\/p>\n
\u8be5\u9879\u7814\u7a76\u662f\u4e00\u9879\u5728\u7ee7\u53d1\u4e8e\u65b0\u751f\u8840\u7ba1\u6027\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\uff08nAMD\uff09\u7684\u6d3b\u52a8\u6027\u9ec4\u6591\u4e2d\u5fc3\u51f9\u4e0b\u6216\u4e2d\u5fc3\u51f9\u65c1\u8109\u7edc\u819c\u65b0\u751f\u8840\u7ba1\u7684\u53d7\u8bd5\u8005\u4e2d\u8fdb\u884c\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u591a\u4e2d\u5fc3\u3001\u6d3b\u6027\u5bf9\u7167\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u7814\u7a76\u4e3b\u8981\u76ee\u7684\u4e3a\u8bc4\u4f30IBI302\u53cc\u9776\u70b9\u836f\u7269\u6cbb\u7597nAMD\u7684\u6709\u6548\u6027\u4e0e\u5b89\u5168\u6027\u3002<\/p>\n
\u6297VEGF\u836f\u7269\u5df2\u7ecf\u6210\u4e3anAMD\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u5f0f\uff1a\u57fa\u4e8e\u6291\u5236VEGF\uff0c\u5927\u90e8\u5206\u60a3\u8005\u7684\u89c6\u529b\u548c\u773c\u90e8\u89e3\u5256\u5b66\u6307\u6807\u5747\u53ef\u5f97\u5230\u663e\u8457\u6539\u5584\u3002\u4f46\u5927\u90e8\u5206\u5355\u4e00\u9776\u70b9\u7684\u6297VEGF\u836f\u7269\u4e5f\u5b58\u5728\u4e00\u4e9b\u95ee\u9898\uff0c\u6bd4\u5982\uff1a\u957f\u671f\u7528\u836f\u540e\u89c6\u529b\u83b7\u76ca\u7684\u9010\u6e10\u4e22\u5931\u4ee5\u53ca\u89c6\u7f51\u819c\u7ea4\u7ef4\u5316\u6216\u9ec4\u6591\u533a\u89c6\u7f51\u819c\u840e\u7f29\u7684\u51fa\u73b0\u3002\u6709\u79d1\u5b66\u7814\u7a76\u63d0\u793a\uff0c\u8865\u4f53\u9014\u5f84\u7684\u6d3b\u5316\u4e0d\u4ec5\u53c2\u4e0e\u4e86AMD\u7684\u53d1\u751f\u548c\u53d1\u5c55\uff0c\u8fd8\u53ef\u80fd\u53c2\u4e0e\u4e86\u89c6\u7f51\u819c\u840e\u7f29\u548c\u7ea4\u7ef4\u5316\u7684\u75c5\u7406\u8fc7\u7a0b\u3002IBI302\u4f5c\u4e3a\u5168\u7403\u9996\u4e2a\u9776\u5411VEGF\u548c\u8865\u4f53\u7684\u53cc\u7279\u5f02\u6027\u878d\u5408\u86cb\u767d\uff0c\u53ef\u4ee5\u540c\u65f6\u6291\u5236VEGF\u4ecb\u5bfc\u7684\u4fe1\u53f7\u901a\u8def\u548c\u51cf\u8f7b\u8865\u4f53\u6d3b\u5316\u4ecb\u5bfc\u7684\u708e\u75c7\u53cd\u5e94\u3002\u5df2\u5f00\u5c55\u7684\u4e24\u9879I\u671f\u5355\u6b21\/\u591a\u6b21\u7ed9\u836f\u7684\u5242\u91cf\u9012\u589e\u7814\u7a76\u7684\u7ed3\u679c\u521d\u6b65\u663e\u793a\u4e86IBI302\u5728nAMD\u60a3\u8005\u4e2d\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff1a\u7597\u6548\u65b9\u9762\uff0c\u53ef\u4ee5\u63d0\u9ad8\u6700\u4f73\u77eb\u6b63\u89c6\u529b\u3001\u6539\u5584\u89c6\u7f51\u819c\u539a\u5ea6\u548c\u65b0\u751f\u8840\u7ba1\u7684\u6e17\u6f0f\u4e0e\u603b\u9762\u79ef\uff1b\u5b89\u5168\u6027\u603b\u4f53\u7279\u5f81\u4e0e\u73b0\u6709\u5355\u9776\u70b9\u6297VEGF\u836f\u7269\u7c7b\u4f3c\u3002\u6b63\u5728\u5f00\u5c55\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u9664\u4e86\u8bc4\u4f30IBI302\u5728\u6539\u5584\u89c6\u529b\u548c\u89c6\u7f51\u819c\u539a\u5ea6\u4e0a\u7684\u7597\u6548\uff0c\u8fd8\u4f1a\u7740\u91cd\u89c2\u5bdf\u5176\u5bf9\u9ec4\u6591\u840e\u7f29\u53ca\u7ea4\u7ef4\u5316\u7684\u6f5c\u5728\u6539\u5584\u4f5c\u7528\u3002<\/p>\n
\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u9644\u5c5e\u4e0a\u6d77\u5e02\u7b2c\u4e00\u4eba\u6c11\u533b\u9662\u5b59\u6653\u4e1c\u6559\u6388\u8868\u793a\uff1a\u201c\u76ee\u524d\uff0c\u4ee5VEGF-A\u4e3a\u9776\u70b9\u7684\u6297\u4f53\u7c7b\u836f\u7269\u5df2\u6210\u4e3a\u65b0\u751f\u8840\u7ba1\u6027\u773c\u5e95\u75c5\u7684\u4e00\u7ebf\u6cbb\u7597\uff0c\u4f46\u9488\u5bf9VEGF\u548c\u8865\u4f53\u4e24\u4e2a\u9776\u70b9\u7684\u53cc\u7279\u5f02\u6027\u878d\u5408\u86cb\u767d\u7c7b\u836f\u7269\u7684\u5f00\u53d1\u5728\u540c\u7c7b\u4e34\u5e8a\u7814\u7a76\u4e2d\u5c1a\u5c5e\u5168\u7403\u7a7a\u767d\u3002IBI302\u4f5c\u4e3a\u6cbb\u7597\u773c\u5e95\u75c5\u7684\u5168\u7403\u521b\u65b0\u836f\uff0c\u5df2\u7ecf\u5b8c\u6210\u7684\u5355\u6b21\u548c\u591a\u6b21\u7ed9\u836f\u7684\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u63d0\u793a\uff0c\u5176\u5b89\u5168\u6027\u826f\u597d\uff0c\u6539\u5584\u89c6\u529b\u548c\u89c6\u7f51\u819c\u539a\u5ea6\u7684\u7597\u6548\u660e\u786e\u3002II\u671f\u4e34\u5e8a\u7814\u7a76\u7684\u5f00\u5c55\u5c06\u63a2\u7d22\u5176\u9488\u5bf9\u9ec4\u6591\u840e\u7f29\u548c\u89c6\u7f51\u819c\u7ea4\u7ef4\u5316\u7684\u7597\u6548\uff0c\u6709\u671b\u7a81\u7834\u65e2\u6709\u836f\u7269\u7597\u6548\u7684\u5c40\u9650\u6027\uff0c\u63d0\u4f9b\u5168\u65b0\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u4ee5\u9020\u798f\u5e7f\u5927\u60a3\u8005\u3002\u201d<\/p>\n
\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u96c6\u56e2\u533b\u5b66\u79d1\u5b66\u4e0e\u6218\u7565\u7279\u75c5\u90e8\u6267\u884c\u603b\u76d1\u94b1\u956d\u535a\u58eb\u8868\u793a\uff1a\u201cIBI302\u662f\u7531\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u81ea\u4e3b\u7814\u53d1\u7684\u5168\u7403\u9996\u521b\u6297VEGF-\u8865\u4f53\u53cc\u9776\u70b9\u836f\u7269\uff0c\u963b\u65adVEGF\u7684\u540c\u65f6\uff0c\u9776\u5411\u8865\u4f53\u7cfb\u7edf\u7684\u6d3b\u5316\uff0c\u5df2\u4f5c\u4e3a1\u7c7b\u65b0\u836f\u83b7\u5f97\u56fd\u5bb6\u79d1\u6280\u90e8\u91cd\u5927\u65b0\u836f\u4e13\u9879\u8bfe\u9898\u7684\u652f\u6301\u3002IBI302\u65e8\u5728\u901a\u8fc7\u589e\u52a0\u989d\u5916\u7684\u9776\u70b9\uff0c\u4ecenAMD\u53d1\u75c5\u673a\u5236\u7684\u89d2\u5ea6\uff0c\u63d0\u4f9b\u66f4\u6709\u9488\u5bf9\u6027\u7684\u6cbb\u7597\u548c\u5e72\u9884\u3002\u6211\u4eec\u5e0c\u671b\u80fd\u901a\u8fc7\u5f00\u53d1IBI302\u8fd9\u4e00\u521b\u65b0\u6027\u836f\u7269\uff0c\u4e3a\u533b\u751f\u63d0\u4f9b\u66f4\u597d\u7684\u4e34\u5e8a\u6cbb\u7597\u65b9\u6848\uff0c\u4e3a\u5e7f\u5927\u7684AMD\u60a3\u8005\u53ca\u5176\u5bb6\u5ead\u5e26\u6765\u66f4\u591a\u548c\u66f4\u957f\u4e45\u7684\u83b7\u76ca\u3002\u201d <\/p>\n
\u5173\u4e8e<\/b>IBI302<\/b><\/p>\n
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IBI302 I\u671f\u5355\u5242\u91cf\u722c\u5761\u7684\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u5df2\u57282020\u5e7411\u6708\u7684\u7f8e\u56fd\u773c\u79d1\u5e74\u4f1a\u4e0a\u9996\u6b21\u516c\u5e03\u3002I\u671f\u4e34\u5e8a\u7814\u7a76\u5171\u7eb3\u516531\u4f8b\u53d7\u8bd5\u8005\uff0c\u6240\u6709\u53d7\u8bd5\u8005\u5747\u63a5\u53d7\u5355\u6b21\u73bb\u7483\u4f53\u8154\u6ce8\u5c04IBI302\uff0c\u672a\u62a5\u544a\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u548c\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff0c\u5c55\u73b0\u51fa\u4e86IBI302\u826f\u597d\u7684\u5b89\u5168\u6027\u4e0e\u8010\u53d7\u6027\u3002\u7ed9\u836f\u540e\u4e00\u5468\u540e\u5373\u53ef\u89c2\u5bdf\u5230\u89c6\u529b\u63d0\u9ad8\u548c\u89c6\u7f51\u819c\u6c34\u80bf\u7684\u51cf\u8f7b\u3002\u81f3\u7ed9\u836f\u540e28\u5929\uff0c31\u4f8b\u53d7\u8bd5\u8005\u7684\u5e73\u5747\u6700\u4f73\u77eb\u6b63\u89c6\u529b\u8f83\u57fa\u7ebf\u63d0\u9ad86\u4e2a\u5b57\u6bcd\uff1b\u5e73\u5747\u4e2d\u592e\u533a\u89c6\u7f51\u819c\u539a\u5ea6\u8f83\u57fa\u7ebf\u51cf\u5c11141.2\u5fae\u7c73\uff0c\u4e14\u90e8\u5206\u60a3\u8005\u7684\u7597\u6548\u6301\u7eed\u5230\u4e86\u7ed9\u836f\u540e6\u5468\u3002<\/p>\n
\u5173\u4e8e<\/b>nAMD<\/b><\/p>\n
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