{"id":28445,"date":"2021-04-29T19:00:00","date_gmt":"2021-04-29T12:00:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021042919000028445"},"modified":"2021-04-29T21:40:38","modified_gmt":"2021-04-29T13:40:38","slug":"mirum%e5%88%b6%e8%8d%af%e4%b8%8e%e5%8c%97%e6%b5%b7%e5%ba%b7%e6%88%90%e7%ad%be%e8%ae%a2maralixibat%e5%a4%a7%e4%b8%ad%e5%8d%8e%e5%8c%ba%e5%bc%80%e5%8f%91%e5%92%8c%e5%95%86%e4%b8%9a%e5%8c%96%e7%8b%ac","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021042919000028445","title":{"rendered":"Mirum\u5236\u836f\u4e0e\u5317\u6d77\u5eb7\u6210\u7b7e\u8ba2Maralixibat\u5927\u4e2d\u534e\u533a\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u72ec\u5bb6\u8bb8\u53ef\u534f\u8bae"},"content":{"rendered":"

– \u5317\u6d77\u5eb7\u6210\u5c06\u5f15\u9886Maralixibat\u5728\u534e\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u8fdb\u7a0b\u5e76\u6269\u5c55\u5176\u7f55\u89c1\u75c5\u7814\u53d1\u7ba1\u7ebf<\/span><\/p>\n

– Mirum\u6709\u6743\u83b7\u5f97\u603b\u8ba11.2\u4ebf\u7f8e\u5143\u7684\u9884\u4ed8\u6b3e\u53ca\u91cc\u7a0b\u7891\u6b3e\u9879\u548c\u53ef\u89c2\u7684\u53cc\u4f4d\u6570\u7684\u68af\u5ea6\u7279\u8bb8\u6743\u4f7f\u7528\u8d39<\/span><\/p>\n

\u7f8e\u56fd\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u798f\u65af\u7279\u5e02\u548c\u5317\u4eac2021\u5e744\u670829\u65e5 \/\u7f8e\u901a\u793e\/ — Mirum\u5236\u836f\u6709\u9650\u516c\u53f8\uff08\u7eb3\u65af\u8fbe\u514b\uff1aMIRM\uff0c\u4ee5\u4e0b\u7b80\u79f0\u201cMirum\u201d\uff09\u548c\u5317\u6d77\u5eb7\u6210\u5236\u836f\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0\u201c\u5317\u6d77\u5eb7\u6210\u201d\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u53cc\u65b9\u5df2\u7b7e\u8ba2\u8bb8\u53ef\u534f\u8bae\uff0c\u6388\u6743\u5317\u6d77\u5eb7\u6210\u5728\u5927\u4e2d\u534e\u533a\uff08\u5305\u62ec\u4e2d\u56fd\u5927\u9646\u3001\u9999\u6e2f\u3001\u6fb3\u95e8\u548c\u53f0\u6e7e\u5730\u533a\uff09\u5bf9Maralixibat\u8fdb\u884c\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u3002Maralixibat\u662f\u4e00\u79cd\u5728\u7814\u7684\u53e3\u670d\u836f\u7269\uff0c\u76ee\u524d\u6b63\u5728\u5bf9\u5176\u7528\u4e8e\u6cbb\u7597\u591a\u79cd\u80c6\u6c41\u6de4\u79ef\u6027\u809d\u75c5\u8fdb\u884c\u8bc4\u4f30\uff0c\u5305\u62ecAlagille\u7efc\u5408\u75c7\uff08ALGS\uff09\u3001\u8fdb\u884c\u6027\u5bb6\u65cf\u6027\u809d\u5185\u80c6\u6c41\u6de4\u79ef\uff08PFIC\uff09\u548c\u80c6\u7ba1\u95ed\u9501\uff08BA\uff09\u3002<\/p>\n

Maralixibat \u9776\u5411\u7eb3\u4f9d\u8d56\u6027\u80c6\u6c41\u9178\u8f6c\u8fd0\u86cb\u767d\uff08ASBT\uff09\uff0c\u6700\u7ec8\u53ef\u964d\u4f4e\u5168\u8eab\u6027\u80c6\u6c41\u9178\u6c34\u5e73\uff0c\u4ece\u800c\u51cf\u5c11\u7531\u6b64\u4ecb\u5bfc\u7684\u809d\u810f\u635f\u4f24\u3002\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u63a5\u53d7Maralixibat \u7528\u4e8e\u6cbb\u7597ALGS\u60a3\u8005\u7684\u80c6\u6c41\u6de4\u79ef\u7619\u75d2\u75c7\u7684\u65b0\u836f\u7533\u8bf7\uff08NDA\uff09\uff0c\u5e76\u4e14\u5728\u8fdb\u884c\u4f18\u5148\u5ba1\u8bc4\u3002\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\u6b63\u5728\u5ba1\u8bc4Maralixibat \u7528\u4e8e\u6cbb\u7597PFIC2\u7684\u7533\u8bf7\u3002Mirum \u5df2\u7ecf\u542f\u52a8\u5176\u7528\u4e8e\u6cbb\u7597\u80c6\u7ba1\u95ed\u9501\uff08BA\uff09\u7684\u5168\u74032b\u671f\u4e34\u5e8a\u7814\u7a76\uff08EMBARK\uff09\u3002<\/p>\n

\u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0c\u5317\u6d77\u5eb7\u6210\u5df2\u83b7\u5f97\u5728\u5927\u4e2d\u534e\u533a\u9488\u5bf9ALGS\uff0c PFIC\u548cBA\u5f00\u53d1\u548c\u5546\u4e1aMaralixibat\u7684\u72ec\u5bb6\u6388\u6743\u3002\u4f5c\u4e3a\u4ea4\u6362\uff0c Mirum\u6709\u6743\u83b7\u5f971100\u4e07\u7f8e\u5143\u7684\u9884\u4ed8\u6b3e\uff0c\u7814\u53d1\u8d44\u91d1\uff0c\u548c\u5728\u5b9e\u73b0\u672a\u6765\u6ce8\u518c\u548c\u5546\u4e1a\u5316Maralixibat\u540e\u6700\u9ad81.09\u4ebf\u7f8e\u5143\u7684\u91cc\u7a0b\u7891\u6b3e\u9879\uff0c\u4ee5\u53ca\u57fa\u4e8e\u4ea7\u54c1\u51c0\u9500\u552e\u989d\u53ef\u89c2\u7684\u53cc\u4f4d\u6570\u7684\u68af\u5ea6\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002<\/p>\n

\u5317\u6d77\u5eb7\u6210\u5c06\u4e0eMirum \u5408\u4f5c\uff0c\u8d1f\u8d23\u76d1\u7763Mirum\u5728\u4e2d\u56fd\u7684\u4e34\u5e8a\u7814\u7a76\u57fa\u5730\uff0c\u4ee5\u52a0\u5feb\u8fd1\u671f\u5728\u80c6\u7ba1\u95ed\u9501\uff08BA\uff09\u60a3\u8005\u4e2d\u542f\u52a8\u7684\u5168\u74032b\u671fEMBARK\u7814\u7a76\u5165\u7ec4\u3002\u5728\u4e00\u5b9a\u6761\u4ef6\u4e0b\uff0c\u5317\u6d77\u5eb7\u6210\u4e5f\u6709\u6743\u5728\u5927\u4e2d\u534e\u533a\u751f\u4ea7Maralixibat\u3002<\/p>\n

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\u76f8\u5173\u94fe\u63a5 :<\/p>\n

http:\/\/www.canbridgepharma.com<\/p>\n","protected":false},"excerpt":{"rendered":"

– \u5317\u6d77\u5eb7\u6210\u5c06\u5f15\u9886Maralixibat\u5728\u534e\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u8fdb\u7a0b\u5e76\u6269\u5c55\u5176\u7f55\u89c1\u75c5\u7814\u53d1\u7ba1\u7ebf – Mirum\u6709\u6743\u83b7\u5f97\u603b\u8ba11.2\u4ebf\u7f8e\u5143\u7684\u9884\u4ed8\u6b3e\u53ca\u91cc\u7a0b\u7891\u6b3e\u9879\u548c\u53ef\u89c2\u7684\u53cc\u4f4d\u6570\u7684\u68af\u5ea6\u7279\u8bb8\u6743\u4f7f\u7528\u8d39 \u7f8e\u56fd\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u798f\u65af\u7279\u5e02\u548c\u5317\u4eac2021\u5e744\u670829\u65e5 \/\u7f8e\u901a\u793e\/ — Mirum\u5236\u836f\u6709\u9650\u516c\u53f8\uff08\u7eb3\u65af\u8fbe\u514b\uff1aMIRM\uff0c\u4ee5\u4e0b\u7b80\u79f0\u201cMirum\u201d\uff09\u548c\u5317\u6d77\u5eb7\u6210\u5236\u836f\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0\u201c\u5317\u6d77\u5eb7\u6210\u201d\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u53cc\u65b9\u5df2\u7b7e\u8ba2\u8bb8\u53ef\u534f\u8bae\uff0c\u6388\u6743\u5317\u6d77\u5eb7\u6210\u5728\u5927\u4e2d\u534e\u533a\uff08\u5305\u62ec\u4e2d\u56fd\u5927\u9646\u3001\u9999\u6e2f\u3001\u6fb3\u95e8\u548c\u53f0\u6e7e\u5730\u533a\uff09\u5bf9Maralixibat\u8fdb\u884c\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u3002Maralixibat\u662f\u4e00\u79cd\u5728\u7814\u7684\u53e3\u670d\u836f\u7269\uff0c\u76ee\u524d\u6b63\u5728\u5bf9\u5176\u7528\u4e8e\u6cbb\u7597\u591a\u79cd\u80c6\u6c41\u6de4\u79ef\u6027\u809d\u75c5\u8fdb\u884c\u8bc4\u4f30\uff0c\u5305\u62ecAlagille\u7efc\u5408\u75c7\uff08ALGS\uff09\u3001\u8fdb\u884c\u6027\u5bb6\u65cf\u6027\u809d\u5185\u80c6\u6c41\u6de4\u79ef\uff08PFIC\uff09\u548c\u80c6\u7ba1\u95ed\u9501\uff08BA\uff09\u3002 Maralixibat \u9776\u5411\u7eb3\u4f9d\u8d56\u6027\u80c6\u6c41\u9178\u8f6c\u8fd0\u86cb\u767d\uff08ASBT\uff09\uff0c\u6700\u7ec8\u53ef\u964d\u4f4e\u5168\u8eab\u6027\u80c6\u6c41\u9178\u6c34\u5e73\uff0c\u4ece\u800c\u51cf\u5c11\u7531\u6b64\u4ecb\u5bfc\u7684\u809d\u810f\u635f\u4f24\u3002\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u63a5\u53d7Maralixibat \u7528\u4e8e\u6cbb\u7597ALGS\u60a3\u8005\u7684\u80c6\u6c41\u6de4\u79ef\u7619\u75d2\u75c7\u7684\u65b0\u836f\u7533\u8bf7\uff08NDA\uff09\uff0c\u5e76\u4e14\u5728\u8fdb\u884c\u4f18\u5148\u5ba1\u8bc4\u3002\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\u6b63\u5728\u5ba1\u8bc4Maralixibat \u7528\u4e8e\u6cbb\u7597PFIC2\u7684\u7533\u8bf7\u3002Mirum \u5df2\u7ecf\u542f\u52a8\u5176\u7528\u4e8e\u6cbb\u7597\u80c6\u7ba1\u95ed\u9501\uff08BA\uff09\u7684\u5168\u74032b\u671f\u4e34\u5e8a\u7814\u7a76\uff08EMBARK\uff09\u3002 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