{"id":27043,"date":"2021-04-19T07:31:00","date_gmt":"2021-04-19T00:31:00","guid":{"rendered":"https:\/\/www.xinwengao.com\/cn\/pr\/2021041907310027043"},"modified":"2021-04-19T21:39:05","modified_gmt":"2021-04-19T13:39:05","slug":"%e5%ba%b7%e5%ae%81%e6%9d%b0%e7%91%9ekn046%e8%81%94%e5%90%88%e5%8c%96%e7%96%97%e6%b2%bb%e7%96%97%e9%9d%9e%e5%b0%8f%e7%bb%86%e8%83%9e%e8%82%ba%e7%99%8c%e2%85%b2%e6%9c%9f%e4%b8%b4%e5%ba%8a%e7%a0%94","status":"publish","type":"post","link":"https:\/\/www.xinwengao.com\/cn\/pr\/2021041907310027043","title":{"rendered":"\u5eb7\u5b81\u6770\u745eKN046\u8054\u5408\u5316\u7597\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\u671f\u7814\u7a76\u8005\u4f1a\u8bae\u987a\u5229\u53ec\u5f00"},"content":{"rendered":"<p><p>\u82cf\u5dde2021\u5e744\u670819\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 2021\u5e744\u670817 \u65e5\uff0c\u5eb7\u5b81\u6770\u745e\u7533\u529e\u7684\u201cKN046\u8054\u5408\u542b\u94c2\u5316\u7597\u5bf9\u6bd4\u5b89\u6170\u5242\u8054\u5408\u542b\u94c2\u5316\u7597\u5728\u665a\u671f\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u7684\u7597\u6548\u4e0e\u5b89\u5168\u6027\u7684\u591a\u4e2d\u5fc3\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u201d\uff08\u7814\u7a76\u7f16\u53f7\uff1aENREACH-LUNG-01\uff09<b>\u4e2d\u671f\u7814\u7a76\u8005\u4f1a\u8bae<\/b>\u5728\u676d\u5dde\u53ec\u5f00\u3002\u540c\u6d4e\u5927\u5b66\u9644\u5c5e\u4e0a\u6d77\u5e02\u80ba\u79d1\u533b\u9662\u80bf\u7624\u79d1\u4e3b\u4efb\u5468\u5f69\u5b58\u6559\u6388\u3001\u6d59\u6c5f\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\u80bf\u7624\u5185\u79d1\u4e3b\u4efb\u5f90\u519c\u6559\u6388\u7b4970\u4f59\u540d\u7814\u7a76\u8005\u5e94\u9080\u51fa\u5e2d\uff0c\u5168\u56fd\u591a\u5bb6\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5fc3\u7814\u7a76\u8005\u7ebf\u4e0a\u53c2\u4f1a\uff0c\u5171\u540c\u5206\u4eab\u9879\u76ee\u8fdb\u5c55\u3002\u5eb7\u5b81\u6770\u745e\u8463\u4e8b\u957f\u517c\u603b\u88c1\u5f90\u9706\u535a\u58eb\u3001\u9996\u5e2d\u533b\u5b66\u5b98Johannes Nippgen\u535a\u58eb\u548cENREACH-LUNG-01\u9879\u76ee\u7ec4\u6210\u5458\u7b49\u53c2\u52a0\u4f1a\u8bae\u3002<\/p>\n<p>ENREACH-LUNG-01\u662f\u4e00\u9879KN046\u8054\u5408\u542b\u94c2\u5316\u7597\u5728\u665a\u671f\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u5f00\u5c55\u7684\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u6027\u2162\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u7531\u4e0a\u6d77\u5e02\u80ba\u79d1\u533b\u9662\u5468\u5f69\u5b58\u6559\u6388\u62c5\u4efb\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u5728\u5168\u56fd60\u591a\u5bb6\u7814\u7a76\u4e2d\u5fc3\u5f00\u5c55\uff0c\u8ba1\u5212\u62db\u52df\u7ea6500\u4f8b\u60a3\u8005\u4ee5\u8bc4\u4f30KN046-5mg\u5242\u91cf\u4e0b\u8054\u5408\u5316\u7597\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder2006\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/1490105\/image_1.html\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/image_1-888.jpg\" title=\"\" alt=\"\" \/><\/a><br \/><span><\/span><\/p>\n<\/p><\/div>\n<p>\u4f1a\u4e0a\uff0c\u540c\u6d4e\u5927\u5b66\u9644\u5c5e\u4e0a\u6d77\u5e02\u80ba\u79d1\u533b\u9662\u80bf\u7624\u79d1\u4e3b\u4efb\u5468\u5f69\u5b58\u6559\u6388\u81f4\u5f00\u573a\u8f9e\uff0c\u4ece\u5168\u7403\u80ba\u764c\u6cbb\u7597\u9886\u57df\u7684\u5b66\u672f\u7814\u7a76\u89d2\u5ea6\uff0c\u5bf9KN046\u7684ENREACH-LUNG-01\u8bd5\u9a8c\u7ed9\u4e88\u9ad8\u5ea6\u8bc4\u4ef7\u5e76\u5bc4\u4e88\u539a\u671b\uff0c\u5468\u5f69\u5b58\u6559\u6388\u8868\u793a\uff1a\u201c\u514d\u75ab\u7597\u6cd5\u662f\u80ba\u764c\u6cbb\u7597\u9886\u57df\u7684\u91cd\u8981\u7814\u7a76\u8fdb\u5c55\uff0c\u56fd\u9645\u4e0a\u4f17\u591a\u7814\u7a76\u8ba9\u60a3\u8005\u770b\u5230\u4e86\u66d9\u5149\uff0c\u4f46\u60a3\u8005\u7684\u603b\u4f53\u9884\u540e\u548c\u8fdc\u671f\u7597\u6548\u4ecd\u7136\u4e9f\u5f85\u63d0\u9ad8\u3002\u5eb7\u5b81\u6770\u745e\u662f\u4e2d\u56fd\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u836f\u4f01\u4e2d\u7684\u4f7c\u4f7c\u8005\uff0c\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53KN046\u7684ENREACH-LUNG-01\u8bd5\u9a8c\u662f<span id=\"spanHghlt1d24\">\u5168\u7403\u9996\u4e2a<\/span>\u53cc\u6297\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5176\u6709\u6f5c\u529b\u6539\u53d8\u80ba\u764c\u7684\u6cbb\u7597\u683c\u5c40\u3002\u6211\u4eec\u671f\u5f85\u5404\u4f4d\u7814\u7a76\u8005\u5171\u540c\u52aa\u529b\uff0c\u65e9\u65e5\u5b8c\u6210\u8fd9\u9879\u7814\u7a76\uff0c\u63a8\u52a8\u4e2d\u56fd\u539f\u7814\u7684\u6700\u524d\u6cbf\u3001\u9ad8\u8d28\u91cf\u7684\u514d\u75ab\u6cbb\u7597\u836f\u7269\u8d70\u5411\u4e16\u754c\uff0c\u4e3a\u5168\u7403\u80ba\u764c\u6cbb\u7597\u589e\u6dfb\u4e2d\u56fd\u529b\u91cf\u3002\u201d<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder4962\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/1490055\/image_2.html\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/image_2-743.jpg\" title=\"\" alt=\"\" \/><\/a><br \/><span><\/span><\/p>\n<\/p><\/div>\n<p>\u5eb7\u5b81\u6770\u745e\u8463\u4e8b\u957f\u517c\u603b\u88c1\u5f90\u9706\u535a\u58eb\u81f4\u6b22\u8fce\u8f9e\uff0c\u63d0\u7eb2\u6308\u9886\u5730\u6982\u8ff0\u4e86\u5eb7\u5b81\u6770\u745e\u5728\u6297\u80bf\u7624\u751f\u7269\u836f\u9886\u57df\u7684\u7814\u53d1\u60c5\u51b5\u3002\u5f90\u9706\u535a\u58eb\u8868\u793a\uff1a\u201c\u5eb7\u5b81\u6770\u745e\u59cb\u7ec8\u4e13\u6ce8\u4e8e\u521b\u65b0\u6297\u80bf\u7624\u751f\u7269\u5927\u5206\u5b50\u836f\u7269\u7684\u7814\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\uff0c\u5e76\u91cd\u70b9\u5173\u6ce8\u5c1a\u672a\u6ee1\u8db3\u7684\u80bf\u7624\u6cbb\u7597\u9700\u6c42\u3002KN046\u5177\u6709\u72ec\u7279\u6297\u80bf\u7624\u673a\u5236\uff0c\u5728\u80ba\u764c\u3001\u80f8\u817a\u764c\u3001\u4e09\u9634\u4e73\u817a\u764c\u7b49\u96be\u6cbb\u6027\u80bf\u7624\u4e34\u5e8a\u9879\u76ee\u4e2d\u663e\u793a\u51fa\u4e86\u4ee4\u4eba\u5370\u8c61\u6df1\u523b\u7684\u60a3\u8005\u751f\u5b58\u83b7\u76ca\u3002ENREACH-LUNG-01\u8bd5\u9a8c\u662f<span id=\"spanHghltb113\">\u5168\u7403\u8303\u56f4\u5185\u7b2c\u4e00\u4e2a<\/span>\u53cc\u7279\u5f02\u6027\u6297\u4f53\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6709\u6f5c\u529b\u53d6\u5f97\u6781\u5177\u4ef7\u503c\u7684\u4e34\u5e8a\u8bc1\u636e\uff0c\u4e3a\u5168\u7403\u80bf\u7624\u6cbb\u7597\u5e26\u6765\u6307\u5bfc\u610f\u4e49\u3002\u6211\u4eec\u671f\u5f85\u5728\u5404\u5730\u8bd5\u9a8c\u4e2d\u5fc3\u5404\u4f4d\u4e13\u5bb6\u7684\u5171\u540c\u52aa\u529b\u4e0b\u65e9\u65e5\u5b8c\u6210\u8bd5\u9a8c\uff0c\u4e3a\u5e7f\u5927\u80bf\u7624\u60a3\u8005\u5e26\u6765\u751f\u5b58\u798f\u7949\u3002\u201d<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder1814\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/1490054\/image_3.html\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/www.xinwengao.com\/cn\/wp-content\/uploads\/image_3-559.jpg\" title=\"\" alt=\"\" \/><\/a><br \/><span><\/span><\/p>\n<\/p><\/div>\n<p>\u5eb7\u5b81\u6770\u745e\u9996\u5e2d\u533b\u5b66\u5b98Johannes Nippgen \u535a\u58eb\u91cd\u70b9\u4ecb\u7ecd\u4e86\u4e34\u5e8a\u9636\u6bb5\u65b0\u836f\u7684\u5f00\u53d1\u7b56\u7565\u53ca\u4e34\u5e8a\u5f00\u53d1\u8ba1\u5212\u3002Johannes Nippgen \u535a\u58eb\u8868\u793a\uff1a\u201cKN046\u5728\u524d\u671f\u591a\u4e2a\u80bf\u7624\u9002\u5e94\u75c7\u8d85\u8fc7600\u4f8b\u60a3\u8005\u53c2\u4e0e\u7684\u4e34\u5e8a\u7814\u7a76\u4e2d\u663e\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u7597\u6548\uff0c\u6211\u4eec\u5bf9\u8fd9\u9879<span id=\"spanHghlt1959\">\u5168\u7403\u9996\u4e2a<\/span>\u542f\u52a8\u7684PD-L1\/ CTLA-4 \u53cc\u7279\u5f02\u6027\u6297\u4f53\u5927\u89c4\u6a21\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u5145\u6ee1\u671f\u5f85\uff0c\u5e0c\u671b\u80fd\u591f\u901a\u8fc7\u8fd9\u9879\u7814\u7a76\u4e0d\u4ec5\u4e3a\u5168\u7403\u80ba\u764c\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u4e5f\u80fd\u591f\u4e3a\u6211\u4eec\u6301\u7eed\u5229\u7528\u516c\u53f8\u7684\u6280\u672f\u5e73\u53f0\u5f00\u53d1\u5168\u65b0\u836f\u7269\u63d0\u4f9b\u65b0\u7684\u601d\u8def\u548c\u65b9\u5411\u3002\u201d<\/p>\n<p>\u4f1a\u8bae\u7531\u540c\u6d4e\u5927\u5b66\u9644\u5c5e\u4e0a\u6d77\u5e02\u80ba\u79d1\u533b\u9662\u80bf\u7624\u79d1\u4e3b\u4efb\u5468\u5f69\u5b58\u6559\u6388\u3001\u6d59\u6c5f\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\u80bf\u7624\u5185\u79d1\u4e3b\u4efb\u5f90\u519c\u6559\u6388\u4e3b\u6301\uff0c\u4e0a\u6d77\u80ba\u79d1\u533b\u9662\u718a\u5b89\u7a33\u6559\u6388\u3001\u90d1\u5dde\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\u674e\u9192\u4e9a\u6559\u6388\u5206\u522b\u5206\u4eab\u4e86ENREACH-LUNG-01\u4e34\u5e8a\u7814\u7a76\u7684\u7ecf\u9a8c\u548c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7814\u7a76\u8fdb\u5c55\uff0c\u76ee\u524d\u8fd9\u4e00\u591a\u4e2d\u5fc3\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u5df2\u7ecf\u572850\u591a\u5bb6\u7814\u7a76\u4e2d\u5fc3\u542f\u52a8\uff0c\u5165\u7ec4\u8fdb\u5c55\u987a\u5229\uff0c\u9884\u8ba15\u6708\u4efd\u5168\u56fd\u7ea660\u5bb6\u7814\u7a76\u4e2d\u5fc3\u5c06\u5168\u90e8\u542f\u52a8\uff0c\u9884\u8ba1\u4eca\u5e74\u5e74\u5e95\u5c06\u770b\u5230\u9996\u6b21\u671f\u4e2d\u5206\u6790\u6570\u636e\u3002<\/p>\n<p><b>\u5173\u4e8e<\/b><b>KN046<\/b><\/p>\n<p>KN046\u662f\u5eb7\u5b81\u6770\u745e\u81ea\u4e3b\u7814\u53d1\u7684PD-L1\/CTLA-4\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u5176\u521b\u65b0\u8bbe\u8ba1\u5305\u62ec\uff1a\u91c7\u7528\u673a\u5236\u4e0d\u540c\u7684CTLA-4\u4e0ePD-L1\u5355\u57df\u6297\u4f53\u878d\u5408\u7ec4\u6210\uff1b\u53ef\u9776\u5411\u5bcc\u96c6\u4e8ePD-L1\u9ad8\u8868\u8fbe\u7684\u80bf\u7624\u5fae\u73af\u5883\u53ca\u6e05\u9664\u6291\u5236\u80bf\u7624\u514d\u75ab\u7684Treg\u3002<\/p>\n<p>KN046\u5728\u6fb3\u5927\u5229\u4e9a\u548c\u4e2d\u56fd\u5df2\u5f00\u5c55\u8986\u76d6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u4e09\u9634\u4e73\u817a\u764c\u3001\u98df\u7ba1\u9cde\u764c\u3001\u809d\u764c\u3001\u80f0\u817a\u764c\u7b4910\u4f59\u79cd\u80bf\u7624\u7684\u8fd120\u9879\u4e0d\u540c\u9636\u6bb5\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\u60a3\u8005\u83b7\u5f97\u751f\u5b58\u83b7\u76ca\u7684\u4f18\u52bf\u3002\u7f8e\u56fdFDA\u57fa\u4e8e\u5728\u6fb3\u5927\u5229\u4e9a\u548c\u4e2d\u56fd\u53d6\u5f97\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\uff0c\u6279\u51c6KN046\u5728\u7f8e\u56fd\u76f4\u63a5\u8fdb\u5165\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e76\u4e8e2020\u5e749\u6708\u6388\u4e88KN046\u7528\u4e8e\u6cbb\u7597\u80f8\u817a\u4e0a\u76ae\u80bf\u7624\u7684\u5b64\u513f\u836f\u8d44\u683c\u3002\u76ee\u524dKN046\u4e24\u4e2a\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d\u3002<\/p>\n<p><b>\u5173\u4e8e\u5eb7\u5b81\u6770\u745e<\/b><\/p>\n<p>\u5eb7\u5b81\u6770\u745e\u751f\u7269\u5236\u836f\u4e13\u6ce8\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u521b\u65b0\u6297\u80bf\u7624\u836f\u7269\u30022019\u5e7412\u670812\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u8054\u5408\u4ea4\u6613\u6240\u4e3b\u677f\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a9966\u3002<\/p>\n<p>\u5eb7\u5b81\u6770\u745e\u751f\u7269\u5236\u836f\u5728\u53cc\u7279\u5f02\u6027\u6297\u4f53\u53ca\u86cb\u767d\u8d28\u5de5\u7a0b\u65b9\u9762\u62e5\u6709\u5168\u4ea7\u4e1a\u94fe\u7684\u53d1\u73b0\u3001\u7814\u53d1\u548c\u5236\u9020\u5e73\u53f0\u3002\u516c\u53f8\u4ea7\u54c1\u7ba1\u7ebf\u5305\u62ec\u5177\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684\u3001\u9ad8\u5ea6\u5dee\u5f02\u5316\u768415\u79cd\u4ee5\u53cc\u6297\u4e3a\u4e3b\u7684\u6297\u80bf\u7624\u5019\u9009\u836f\u7269\uff0c\u548c\u4e00\u79cdCovid-19\u7684\u591a\u529f\u80fd\u6297\u4f53\uff0c\u5176\u4e2d\u56db\u4e2a\u4ea7\u54c1\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u65e5\u672c\u3001\u6fb3\u5927\u5229\u4e9a\u5904\u4e8e\u2160-\u2162\u671f\u4e34\u5e8a\u3002\u6069\u6c83\u5229\u5355\u6297\u6ce8\u5c04\u6db2(KN035)\u4e0a\u5e02\u7533\u8bf7\u5df2\u83b7\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40(NMPA)\u6b63\u5f0f\u53d7\u7406\u5e76\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u3002<\/p>\n<p>\u516c\u53f8\u62e5\u6709\u5f02\u4e8c\u805a\u4f53\u53ca\u6df7\u5408\u6297\u4f53\u7b49\u591a\u4e2a\u5177\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684\u6280\u672f\u5e73\u53f0\uff0c\u548c\u7b26\u5408\u4e2d\u56fd\u3001\u7f8e\u56fd\u548c\u6b27\u76dfcGMP\u6807\u51c6\u7684\u5927\u89c4\u6a21\u751f\u4ea7\u80fd\u529b\uff0c\u5e76\u4e14\u901a\u8fc7\u5305\u62ec\u6b27\u76dfQP\u5728\u5185\u591a\u6b21\u5ba1\u8ba1\u7684\u5b8c\u6574\u7684\u8d28\u91cf\u4f53\u7cfb\u3002\u516c\u53f8\u81f4\u529b\u4e8e\u5efa\u8bbe\u56fd\u9645\u9886\u5148\u7684\u3001\u591a\u7ef4\u5ea6\u7684\u836f\u7269\u5f00\u53d1\u548c\u4ea7\u4e1a\u5316\u5e73\u53f0\uff0c\u805a\u7126\u591a\u529f\u80fd\u751f\u7269\u5927\u5206\u5b50\u65b0\u836f\uff0c\u60e0\u53ca\u4e2d\u56fd\u548c\u5168\u7403\u7684\u60a3\u8005\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder0\">  <\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u82cf\u5dde2021\u5e744\u670819\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 2021\u5e744\u670817 \u65e5\uff0c\u5eb7\u5b81\u6770\u745e\u7533\u529e\u7684\u201cKN046\u8054\u5408\u542b\u94c2\u5316\u7597\u5bf9\u6bd4\u5b89\u6170\u5242\u8054\u5408\u542b\u94c2\u5316\u7597\u5728\u665a\u671f\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u7684\u7597\u6548\u4e0e\u5b89\u5168\u6027\u7684\u591a\u4e2d\u5fc3\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u201d\uff08\u7814\u7a76\u7f16\u53f7\uff1aENREACH-LUNG-01\uff09\u4e2d\u671f\u7814\u7a76\u8005\u4f1a\u8bae\u5728\u676d\u5dde\u53ec\u5f00\u3002\u540c\u6d4e\u5927\u5b66\u9644\u5c5e\u4e0a\u6d77\u5e02\u80ba\u79d1\u533b\u9662\u80bf\u7624\u79d1\u4e3b\u4efb\u5468\u5f69\u5b58\u6559\u6388\u3001\u6d59\u6c5f\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\u80bf\u7624\u5185\u79d1\u4e3b\u4efb\u5f90\u519c\u6559\u6388\u7b4970\u4f59\u540d\u7814\u7a76\u8005\u5e94\u9080\u51fa\u5e2d\uff0c\u5168\u56fd\u591a\u5bb6\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5fc3\u7814\u7a76\u8005\u7ebf\u4e0a\u53c2\u4f1a\uff0c\u5171\u540c\u5206\u4eab\u9879\u76ee\u8fdb\u5c55\u3002\u5eb7\u5b81\u6770\u745e\u8463\u4e8b\u957f\u517c\u603b\u88c1\u5f90\u9706\u535a\u58eb\u3001\u9996\u5e2d\u533b\u5b66\u5b98Johannes Nippgen\u535a\u58eb\u548cENREACH-LUNG-01\u9879\u76ee\u7ec4\u6210\u5458\u7b49\u53c2\u52a0\u4f1a\u8bae\u3002 ENREACH-LUNG-01\u662f\u4e00\u9879KN046\u8054\u5408\u542b\u94c2\u5316\u7597\u5728\u665a\u671f\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u5f00\u5c55\u7684\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u6027\u2162\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u7531\u4e0a\u6d77\u5e02\u80ba\u79d1\u533b\u9662\u5468\u5f69\u5b58\u6559\u6388\u62c5\u4efb\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u5728\u5168\u56fd60\u591a\u5bb6\u7814\u7a76\u4e2d\u5fc3\u5f00\u5c55\uff0c\u8ba1\u5212\u62db\u52df\u7ea6500\u4f8b\u60a3\u8005\u4ee5\u8bc4\u4f30KN046-5mg\u5242\u91cf\u4e0b\u8054\u5408\u5316\u7597\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002 \u4f1a\u4e0a\uff0c\u540c\u6d4e\u5927\u5b66\u9644\u5c5e\u4e0a\u6d77\u5e02\u80ba\u79d1\u533b\u9662\u80bf\u7624\u79d1\u4e3b\u4efb\u5468\u5f69\u5b58\u6559\u6388\u81f4\u5f00\u573a\u8f9e\uff0c\u4ece\u5168\u7403\u80ba\u764c\u6cbb\u7597\u9886\u57df\u7684\u5b66\u672f\u7814\u7a76\u89d2\u5ea6\uff0c\u5bf9KN046\u7684ENREACH-LUNG-01\u8bd5\u9a8c\u7ed9\u4e88\u9ad8\u5ea6\u8bc4\u4ef7\u5e76\u5bc4\u4e88\u539a\u671b\uff0c\u5468\u5f69\u5b58\u6559\u6388\u8868\u793a\uff1a\u201c\u514d\u75ab\u7597\u6cd5\u662f\u80ba\u764c\u6cbb\u7597\u9886\u57df\u7684\u91cd\u8981\u7814\u7a76\u8fdb\u5c55\uff0c\u56fd\u9645\u4e0a\u4f17\u591a\u7814\u7a76\u8ba9\u60a3\u8005\u770b\u5230\u4e86\u66d9\u5149\uff0c\u4f46\u60a3\u8005\u7684\u603b\u4f53\u9884\u540e\u548c\u8fdc\u671f\u7597\u6548\u4ecd\u7136\u4e9f\u5f85\u63d0\u9ad8\u3002\u5eb7\u5b81\u6770\u745e\u662f\u4e2d\u56fd\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u836f\u4f01\u4e2d\u7684\u4f7c\u4f7c\u8005\uff0c\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53KN046\u7684ENREACH-LUNG-01\u8bd5\u9a8c\u662f\u5168\u7403\u9996\u4e2a\u53cc\u6297\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5176\u6709\u6f5c\u529b\u6539\u53d8\u80ba\u764c\u7684\u6cbb\u7597\u683c\u5c40\u3002\u6211\u4eec\u671f\u5f85\u5404\u4f4d\u7814\u7a76\u8005\u5171\u540c\u52aa\u529b\uff0c\u65e9\u65e5\u5b8c\u6210\u8fd9\u9879\u7814\u7a76\uff0c\u63a8\u52a8\u4e2d\u56fd\u539f\u7814\u7684\u6700\u524d\u6cbf\u3001\u9ad8\u8d28\u91cf\u7684\u514d\u75ab\u6cbb\u7597\u836f\u7269\u8d70\u5411\u4e16\u754c\uff0c\u4e3a\u5168\u7403\u80ba\u764c\u6cbb\u7597\u589e\u6dfb\u4e2d\u56fd\u529b\u91cf\u3002\u201d \u5eb7\u5b81\u6770\u745e\u8463\u4e8b\u957f\u517c\u603b\u88c1\u5f90\u9706\u535a\u58eb\u81f4\u6b22\u8fce\u8f9e\uff0c\u63d0\u7eb2\u6308\u9886\u5730\u6982\u8ff0\u4e86\u5eb7\u5b81\u6770\u745e\u5728\u6297\u80bf\u7624\u751f\u7269\u836f\u9886\u57df\u7684\u7814\u53d1\u60c5\u51b5\u3002\u5f90\u9706\u535a\u58eb\u8868\u793a\uff1a\u201c\u5eb7\u5b81\u6770\u745e\u59cb\u7ec8\u4e13\u6ce8\u4e8e\u521b\u65b0\u6297\u80bf\u7624\u751f\u7269\u5927\u5206\u5b50\u836f\u7269\u7684\u7814\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\uff0c\u5e76\u91cd\u70b9\u5173\u6ce8\u5c1a\u672a\u6ee1\u8db3\u7684\u80bf\u7624\u6cbb\u7597\u9700\u6c42\u3002KN046\u5177\u6709\u72ec\u7279\u6297\u80bf\u7624\u673a\u5236\uff0c\u5728\u80ba\u764c\u3001\u80f8\u817a\u764c\u3001\u4e09\u9634\u4e73\u817a\u764c\u7b49\u96be\u6cbb\u6027\u80bf\u7624\u4e34\u5e8a\u9879\u76ee\u4e2d\u663e\u793a\u51fa\u4e86\u4ee4\u4eba\u5370\u8c61\u6df1\u523b\u7684\u60a3\u8005\u751f\u5b58\u83b7\u76ca\u3002ENREACH-LUNG-01\u8bd5\u9a8c\u662f\u5168\u7403\u8303\u56f4\u5185\u7b2c\u4e00\u4e2a\u53cc\u7279\u5f02\u6027\u6297\u4f53\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6709\u6f5c\u529b\u53d6\u5f97\u6781\u5177\u4ef7\u503c\u7684\u4e34\u5e8a\u8bc1\u636e\uff0c\u4e3a\u5168\u7403\u80bf\u7624\u6cbb\u7597\u5e26\u6765\u6307\u5bfc\u610f\u4e49\u3002\u6211\u4eec\u671f\u5f85\u5728\u5404\u5730\u8bd5\u9a8c\u4e2d\u5fc3\u5404\u4f4d\u4e13\u5bb6\u7684\u5171\u540c\u52aa\u529b\u4e0b\u65e9\u65e5\u5b8c\u6210\u8bd5\u9a8c\uff0c\u4e3a\u5e7f\u5927\u80bf\u7624\u60a3\u8005\u5e26\u6765\u751f\u5b58\u798f\u7949\u3002\u201d \u5eb7\u5b81\u6770\u745e\u9996\u5e2d\u533b\u5b66\u5b98Johannes Nippgen \u535a\u58eb\u91cd\u70b9\u4ecb\u7ecd\u4e86\u4e34\u5e8a\u9636\u6bb5\u65b0\u836f\u7684\u5f00\u53d1\u7b56\u7565\u53ca\u4e34\u5e8a\u5f00\u53d1\u8ba1\u5212\u3002Johannes Nippgen \u535a\u58eb\u8868\u793a\uff1a\u201cKN046\u5728\u524d\u671f\u591a\u4e2a\u80bf\u7624\u9002\u5e94\u75c7\u8d85\u8fc7600\u4f8b\u60a3\u8005\u53c2\u4e0e\u7684\u4e34\u5e8a\u7814\u7a76\u4e2d\u663e\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u7597\u6548\uff0c\u6211\u4eec\u5bf9\u8fd9\u9879\u5168\u7403\u9996\u4e2a\u542f\u52a8\u7684PD-L1\/ CTLA-4 \u53cc\u7279\u5f02\u6027\u6297\u4f53\u5927\u89c4\u6a21\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u5145\u6ee1\u671f\u5f85\uff0c\u5e0c\u671b\u80fd\u591f\u901a\u8fc7\u8fd9\u9879\u7814\u7a76\u4e0d\u4ec5\u4e3a\u5168\u7403\u80ba\u764c\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u4e5f\u80fd\u591f\u4e3a\u6211\u4eec\u6301\u7eed\u5229\u7528\u516c\u53f8\u7684\u6280\u672f\u5e73\u53f0\u5f00\u53d1\u5168\u65b0\u836f\u7269\u63d0\u4f9b\u65b0\u7684\u601d\u8def\u548c\u65b9\u5411\u3002\u201d \u4f1a\u8bae\u7531\u540c\u6d4e\u5927\u5b66\u9644\u5c5e\u4e0a\u6d77\u5e02\u80ba\u79d1\u533b\u9662\u80bf\u7624\u79d1\u4e3b\u4efb\u5468\u5f69\u5b58\u6559\u6388\u3001\u6d59\u6c5f\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\u80bf\u7624\u5185\u79d1\u4e3b\u4efb\u5f90\u519c\u6559\u6388\u4e3b\u6301\uff0c\u4e0a\u6d77\u80ba\u79d1\u533b\u9662\u718a\u5b89\u7a33\u6559\u6388\u3001\u90d1\u5dde\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\u674e\u9192\u4e9a\u6559\u6388\u5206\u522b\u5206\u4eab\u4e86ENREACH-LUNG-01\u4e34\u5e8a\u7814\u7a76\u7684\u7ecf\u9a8c\u548c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7814\u7a76\u8fdb\u5c55\uff0c\u76ee\u524d\u8fd9\u4e00\u591a\u4e2d\u5fc3\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u5df2\u7ecf\u572850\u591a\u5bb6\u7814\u7a76\u4e2d\u5fc3\u542f\u52a8\uff0c\u5165\u7ec4\u8fdb\u5c55\u987a\u5229\uff0c\u9884\u8ba15\u6708\u4efd\u5168\u56fd\u7ea660\u5bb6\u7814\u7a76\u4e2d\u5fc3\u5c06\u5168\u90e8\u542f\u52a8\uff0c\u9884\u8ba1\u4eca\u5e74\u5e74\u5e95\u5c06\u770b\u5230\u9996\u6b21\u671f\u4e2d\u5206\u6790\u6570\u636e\u3002 \u5173\u4e8eKN046 KN046\u662f\u5eb7\u5b81\u6770\u745e\u81ea\u4e3b\u7814\u53d1\u7684PD-L1\/CTLA-4\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u5176\u521b\u65b0\u8bbe\u8ba1\u5305\u62ec\uff1a\u91c7\u7528\u673a\u5236\u4e0d\u540c\u7684CTLA-4\u4e0ePD-L1\u5355\u57df\u6297\u4f53\u878d\u5408\u7ec4\u6210\uff1b\u53ef\u9776\u5411\u5bcc\u96c6\u4e8ePD-L1\u9ad8\u8868\u8fbe\u7684\u80bf\u7624\u5fae\u73af\u5883\u53ca\u6e05\u9664\u6291\u5236\u80bf\u7624\u514d\u75ab\u7684Treg\u3002 KN046\u5728\u6fb3\u5927\u5229\u4e9a\u548c\u4e2d\u56fd\u5df2\u5f00\u5c55\u8986\u76d6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u4e09\u9634\u4e73\u817a\u764c\u3001\u98df\u7ba1\u9cde\u764c\u3001\u809d\u764c\u3001\u80f0\u817a\u764c\u7b4910\u4f59\u79cd\u80bf\u7624\u7684\u8fd120\u9879\u4e0d\u540c\u9636\u6bb5\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\u60a3\u8005\u83b7\u5f97\u751f\u5b58\u83b7\u76ca\u7684\u4f18\u52bf\u3002\u7f8e\u56fdFDA\u57fa\u4e8e\u5728\u6fb3\u5927\u5229\u4e9a\u548c\u4e2d\u56fd\u53d6\u5f97\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\uff0c\u6279\u51c6KN046\u5728\u7f8e\u56fd\u76f4\u63a5\u8fdb\u5165\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e76\u4e8e2020\u5e749\u6708\u6388\u4e88KN046\u7528\u4e8e\u6cbb\u7597\u80f8\u817a\u4e0a\u76ae\u80bf\u7624\u7684\u5b64\u513f\u836f\u8d44\u683c\u3002\u76ee\u524dKN046\u4e24\u4e2a\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d\u3002 \u5173\u4e8e\u5eb7\u5b81\u6770\u745e \u5eb7\u5b81\u6770\u745e\u751f\u7269\u5236\u836f\u4e13\u6ce8\u4e8e\u7814\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u521b\u65b0\u6297\u80bf\u7624\u836f\u7269\u30022019\u5e7412\u670812\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u8054\u5408\u4ea4\u6613\u6240\u4e3b\u677f\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u7801\uff1a9966\u3002 \u5eb7\u5b81\u6770\u745e\u751f\u7269\u5236\u836f\u5728\u53cc\u7279\u5f02\u6027\u6297\u4f53\u53ca\u86cb\u767d\u8d28\u5de5\u7a0b\u65b9\u9762\u62e5\u6709\u5168\u4ea7\u4e1a\u94fe\u7684\u53d1\u73b0\u3001\u7814\u53d1\u548c\u5236\u9020\u5e73\u53f0\u3002\u516c\u53f8\u4ea7\u54c1\u7ba1\u7ebf\u5305\u62ec\u5177\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684\u3001\u9ad8\u5ea6\u5dee\u5f02\u5316\u768415\u79cd\u4ee5\u53cc\u6297\u4e3a\u4e3b\u7684\u6297\u80bf\u7624\u5019\u9009\u836f\u7269\uff0c\u548c\u4e00\u79cdCovid-19\u7684\u591a\u529f\u80fd\u6297\u4f53\uff0c\u5176\u4e2d\u56db\u4e2a\u4ea7\u54c1\u5728\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u65e5\u672c\u3001\u6fb3\u5927\u5229\u4e9a\u5904\u4e8e\u2160-\u2162\u671f\u4e34\u5e8a\u3002\u6069\u6c83\u5229\u5355\u6297\u6ce8\u5c04\u6db2(KN035)\u4e0a\u5e02\u7533\u8bf7\u5df2\u83b7\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40(NMPA)\u6b63\u5f0f\u53d7\u7406\u5e76\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u3002 \u516c\u53f8\u62e5\u6709\u5f02\u4e8c\u805a\u4f53\u53ca\u6df7\u5408\u6297\u4f53\u7b49\u591a\u4e2a\u5177\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684\u6280\u672f\u5e73\u53f0\uff0c\u548c\u7b26\u5408\u4e2d\u56fd\u3001\u7f8e\u56fd\u548c\u6b27\u76dfcGMP\u6807\u51c6\u7684\u5927\u89c4\u6a21\u751f\u4ea7\u80fd\u529b\uff0c\u5e76\u4e14\u901a\u8fc7\u5305\u62ec\u6b27\u76dfQP\u5728\u5185\u591a\u6b21\u5ba1\u8ba1\u7684\u5b8c\u6574\u7684\u8d28\u91cf\u4f53\u7cfb\u3002\u516c\u53f8\u81f4\u529b\u4e8e\u5efa\u8bbe\u56fd\u9645\u9886\u5148\u7684\u3001\u591a\u7ef4\u5ea6\u7684\u836f\u7269\u5f00\u53d1\u548c\u4ea7\u4e1a\u5316\u5e73\u53f0\uff0c\u805a\u7126\u591a\u529f\u80fd\u751f\u7269\u5927\u5206\u5b50\u65b0\u836f\uff0c\u60e0\u53ca\u4e2d\u56fd\u548c\u5168\u7403\u7684\u60a3\u8005\u3002&hellip; <a class=\"read-more\" href=\"https:\/\/www.xinwengao.com\/cn\/pr\/2021041907310027043\">Read More<\/a><\/p>\n","protected":false},"author":556,"featured_media":27048,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1965],"tags":[],"class_list":["post-27043","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-partnerships"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/27043","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/users\/556"}],"replies":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/comments?post=27043"}],"version-history":[{"count":1,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/27043\/revisions"}],"predecessor-version":[{"id":27047,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/posts\/27043\/revisions\/27047"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media\/27048"}],"wp:attachment":[{"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/media?parent=27043"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/categories?post=27043"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.xinwengao.com\/cn\/wp-json\/wp\/v2\/tags?post=27043"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}